BioCopy AG
Copying Biomolecules – B-cell and T-cell Immunotherapies
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c/o Switzerland Innovation Park Basel Area AG Gewerbestrasse 24 4123 Allschwil Switzerland Dr Günter Roth +49-174-78-67-919 guenter.roth@biocopy.de www.biocpy.ch
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IL
BioCopy has developed a globally unique method to copy biomolecules. This patented method is broadly applicable and enables rapid development of both, Bcell and T-cell immunotherapies and diagnostics. The target molecules can derive from a pathogen (for vaccines) or from a tumor (for cancer therapies). BioCopy is thus one of few companies worldwide that addresses two booming billion-dollar markets with its innovative technology platform: ultra-fast target identification for vaccines in the field of infectious diseases and T-cell therapy screenings in the field of oncology.
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Biological Patents
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Request for Further Collaborations
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26 2016 Biochemistry l Biomolecular interaction studies l High-throughput kinetics l Vaccine development l Immuno-oncology Predominantly granted patent portfolio with currently 16 patent families that broadly secure our innovative technology and its applications worldwide We are interested in collaborations with companies in the field of vaccine development and T-cell therapies.
Copying Technology The basis of the BioCopy innovation is a biomolecule copier, which, in analogy to a photocopier, copies DNA, RNA or proteins from a DNA matrix. The genetic information, e.g. of a pathogen, is transferred to a special cavity chip so that each cavity contains a different fragment or mutation of the pathogen genome. Each cavity corresponds to an individual reaction chamber during the copying process. After adding a transcription/translation mixture and sealing the cavity chip with a specially coated glass slide, an individual copy of the contained fragment or mutation is generated in each cavity (“pixel”/ spot) as DNA, RNA or protein. This copy product binds to the slide surface, creating a corresponding array. The resulting microarrays consist of thousands of spots which can be analyzed simultaneously with BioCopy’s SCORE-detection system.
Detection Technology Single color reflectometry (SCORE) enables label-free, real-time, high-throughput screening by analysis of biomolecular interactions and reliable determination of kinetic binding parameters. The SCORE system detects these interactions by measuring the change in layer thickness on the array surface that causes a color change. The SCORE system converts this color change into a binding signal. The graph can then be visualized immediately as an image or video.
