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Collaborations Enzymicals AG

Walther-Rathenau-Str. 49a 17489 Greifswald Germany Dr Rainer Wardenga +49-3834-515470 info@enzymicals.com www.enzymicals.com

LI

20 2009 | S1 Biotech | Chemistry & Analytics | Process Engineering | Kilo Lab & Small-Scale Manufacturing

| Development and scale-up of chemoenzymatic processes incl. DSP | Customer-specific solutions in enzyme technology and biotransformation | Development and production of enzymes | Tailor-made fine chemicals, intermediates, and APIs

IP protected by international patent applications and granted patents

| Broad international academic R&D collaborations | Stakeholder networks | 4-chiral Network | Aminoverse B.V. | ChiralVision B.V. | Candidum GmbH | CMO and CDMO network | EU upPE-T | EU Macbeth

Enzymicals AG

Industrial biocatalysis from gram to tonne We are people who truly believe in the benefits of in-vitro biosynthesis. With technologies, products, and offerings for the industrial implementation of biocatalysis, we support the global industry to enable the upcoming change to biologically inspired production concepts.

Enzymicals is your experienced partner for industrial biocatalysis from gram to tonne-scale, with more than a decade of experience. An interdisciplinary team of 20 scientists and technicians work on biological and chemical topics and represent the necessary know-how in analytics, molecular biology, fermentation, biocatalysis, and process chemistry to provide integrated solutions for industrial biocatalysis. The focus of the independent SME is the development and use of enzymatic processes for complex chemical synthesis, from initial catalyst lead-finding to process optimisation and scale-up, to realise tailor-made solutions for custom development and manufacturing. Our continuous activities in academic partnering and industrial collaborations result in the delivery of state-of-the-art concepts that are applicable at commercial scale. As a result, we add value and enable greener and safer manufacturing procedures.

Products & Services

Individual process solutions, tailor-made enzymes, and customised chemicals Dedicated to designing, developing, and implementing innovative, cost-effective, and scalable chemo-biocatalytic routes to fine chemicals & APIs, Enzymicals offers recognised expertise in the use of enzymatic processes for chemical synthesis. We develop scalable strategies for the synthesis of your desired compound, which includes feasibility studies as well as development and scale-up of the process, including DSP. For this we are able to combine efficient enzymatic and chemical synthesis steps.

Enzymicals is an outstanding resource of enzymes suitable for diagnostics, research, and development, as

well as for commercial production. Our enzyme portfolio contains a continuously expanding biocatalytic toolbox, with innovative biocatalysts from the class of e.g. transaminases, monooxygenases, halohydrin dehalogenases, imine reductases, and hydrolases at desired quality grades to solve customer-specific demands at best performance. Selected products are incorporated in our online catalogue.

We deliver concept-to-completion comprehensive solutions to create high-performance protein-based products and processes. For this, we discover and produce enzymes based on the demands of our customers and partners. Our technology platform covers the identification of suitable catalysts from strain or enzyme collections, databases, or metagenome libraries as well as their functional expression in a range of microbial host systems. This enables us to offer tailor-made protein expression and optimisation as a service. Thus, almost any biocatalyst of interest can be supplied on an analytical and commercial scale. Within our network we provide processes in up to 85 cbm fermenters or for chemical processes in multi-kilogram to tonne scale equipment. A catalyst suitable for the production of your target compound can be optimised via our protein engineering technology to provide the best performance available.

Together with our network partners, we have expanded our services to ASMF filing, regulatory affairs, cGMP production, and bulk scale supply. The combination of best catalysts with optimised chemistry and the integration of processing aspects have enabled us to increase the speed of delivery of effective solutions. Our core working principles are high-quality R&D, professionalism, and customer satisfaction.

Let’s create value together.

Management

Dr Erik de Vries, CEO Dr Sebastian Schätzle, CBO Dr David Liese, COO Dr Rainer Wardenga, BD