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Collaborations LIFE & BRAIN GmbH

Venusberg Campus 1 53127 Bonn Germany Dr Per Hoffmann, Ira Herrmann +49-228-6885-100 +49-228-6885-101 info@lifeandbrain.com www.lifeandbrain.com 35 2002 S1, S2

High throughput generation and interpretation of omics data; stem cell-based customer-specific services for neurological disease modelling and compound development

Several international patents filed or granted covering in-house technologies

Illumina Inc.

LIFE & BRAIN is a biomedical enterprise and commercial hub of the University of Bonn Medical Centre founded in 2002 located in Bonn, Germany. Integrating a unique set of expertise in cellomics and genomics, LIFE & BRAIN aims at delivering the next generation of products and services for research, disease modelling and prediction, compound development and tissue regeneration. The combination of technological know-how and scientific excellence makes LIFE & BRAIN the perfect partner for academic and commercial research.

LIFE & BRAIN products and services

LIFE & BRAIN Genomics is one of the leading service providers for all types of microarray and NGS experiments using Illumina technology in Europe and has longstanding experience in high-throughput generation of “omics” data from biomaterial of humans as well as model organisms. Having a close collaboration with the excellent and internationally renowned scientists from the Institute of Human Genetics in Bonn, LIFE & BRAIN Genomics is continuously developing new applications and pipelines for state-of-the-art generation and interpretation of these “omics” data, which form the basis for understanding the molecular pathogenesis of common diseases and the development of specific diagnostic and therapeutic tools.

LIFE & BRAIN CELLOMICS provides stem cell-based cell culture systems and customer-specific services for neurological disease modelling and compound development. Our areas of competence encompass the generation of induced pluripotent stem cells (iPS cells), neural iPS cell differentiation and customer-specific cell production and assay development.

Proprietary technologies make it possible to generate pure, cryopreservable neural, neuronal and glial cells. from pure, cryopreservable populations. Through our close collaboration with the outstanding scientists at the Institute of Reconstructive Neurobiology and as part of a large number of national and EU-wide research projects, we systematically implement innovative stem cell-based technologies and optimize these technologies for biomedical applications on an industrial scale. Our focus is on assay development: Using healthy and disease-specific iPS cell lines, we develop phenotypic assays together with our clients for use in disease research and drug discovery. Based on established differentiation protocols, we provide the adaptation and optimization of cell production and quality controls.