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Phyton Biotech GmbH

Alter Postweg 1 22926 Ahrensburg Germany Kai Schütte +49-4102-4906-64 +49-4102-4906-69 kai.schuette@phytonbiotech.com www.phytonbiotech.com 75 1993

Comprehensive services for the development and commercialisation of high-value compounds using our award-winning Plant Cell Fermentation (PCF®) Technology.

Established in 1993, Phyton Biotech offers comprehensive process development and commercial manufacturing services for fermentation-based products. Best known for our award-winning and environmentally responsible Plant Cell Fermentation (PCF®) platform, we have expanded our profile into other cell systems, offering development and supply solutions for a wide array of products including phytochemicals, biopharmaceuticals, and other high-value compounds. This PCF® technology coupled with our extensive experience allows Phyton Biotech to serve a variety of global markets, including pharmaceutical, traditional medicines, agricultural, food ingredients, natural health, and cosmetics industries.

Our PCF® technology

PCF® promotes the natural processes of plant cell growth and biosynthetic pathway expression of plant material in a controlled and fully defined bioreactor environment. Starting material is sourced without any environmental impact and the optimal cell cultures are developed in-house. Selected cell lines are scaled up in stirred tank bioreactors without the sunlight requirement. Finally, Phyton Biotech’s specialised product recovery and downstream technology allows for the preparation of extracts and purification of molecules.

Utilising this cutting-edge technology, Phyton Biotech offers a time, risk, and cost balanced path to commercially viable production processes, adding sustainability, reliability, quality, and scalability to the supply chain.

Our unique capabilities address the entire development chain. Phyton Biotech maintains one of the world’s largest plant cell culture collections, allowing for the unique selection and sourcing of plant material. Subsequent cell line development, process development, downstream development, chemical processing, scaleup, and commercial GMP production in up to 75,000L bioreactors guarantees Phyton Biotech’s position as the global leader in PCF® .

Specialty fermentation solutions

Phyton Biotech’s unique state-of-the-art facilities and impressive history of expertise in development and production enable us to carry out other Specialty Fermentation solutions beyond PCF® hand-in-hand with our customers — from first cells to scale-up and through to product recovery. We offer comprehensive services for the development and commercialisation of manufacturing processes for high-value compounds including small molecules and biologicals.

Our API business

Phyton Biotech operates two GMP-certified, FDA and EDQM inspected facilities in Germany and Canada with full in-house QA/RA and QC capabilities, and supplies substantial amounts of Paclitaxel and Docetaxel with full control over the entire upstream and downstream production process. By providing a safe, reliable, highquality supply of finished Active Pharmaceutical Ingredient (API) product that meets USP and EP standards, Phyton Biotech is the largest global commercial provider of Paclitaxel and Docetaxel API via PCF® to a customer base of pharmaceutical manufacturers around the world.

In summary

Through our expertise and experience, Phyton Biotech continues to offer world-class development, supply, and commercial manufacturing solutions in an environmentally responsible and sustainable way through our PCF® and Specialty Fermentation platforms for a wide range of high-value fermentation-based compounds.