New England Biolabs GmbH

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Collaborations Molzym GmbH & Co. KG

Mary-Astell-Straße 10 28359 Bremen Germany Marina Linow +49-421-69-61-62-0 +49-421-69-61-62-11 info@molzym.com www.molzym.com

I

35 2003

Manufacturer and supplier of products: | CE IVD kits for infection diagnosis | Microbial DNA extraction (manual and automated) | PCR assays and master mixes | DNA-free PCR reagents and polymerases | Customised master mixes

Molzym is interested in collaborations that are directed to the development and manufacturing of individualised, pre-analytic, and analytic solutions, including automation.

Molzym was founded as a privately owned enterprise in Bremen, Germany, in 2003. Ever since, Molzym has been committed to the development of innovative solutions to serve biological research and diagnosis of infectious diseases. In December 2019, Molzym joined Gradian Diagnostics to accelerate growth of its molecular diagnostic solutions. Our developmental efforts are particularly focused on new processes enabling and facilitating the molecular diagnosis of infectious diseases caused by bacteria and fungi. Meanwhile, more than 50 high-quality products are available for molecular microbial analysis by PCR- and NGS-based methods in 30 countries worldwide.

Expertise

Molzym manufactures ultra-clean and highly active amplification reagents and kits for microbial DNA extraction from a variety of clinical specimens. Reagents and consumables are supplied free of contaminating microbial DNA – guaranteed lot by lot. Our customers appreciate the ability to increase the number of amplification cycles and thus lower the limit of detection dramatically without false positive results arising from contaminating microbial DNA. Another core expertise is Molzym’s unique MolYsis™ technology for the depletion of host DNA from usually sterile human and animal samples, a well-known factor that negatively influences sensitive PCR and microbiome analysis at low microbial loads.

Products & automation

MolYsis™ is Molzym’s proprietary technology of host DNA depletion, allowing targeted isolation of microbial DNA from a great variety of clinical samples. Ultra-pure, DNA-free PCR reagents and master mixes allow for the precise detection of microbes in humans and animal models. Complete assays for the broad-range amplification of selected regions of the 16S and 18S rRNA genes of bacteria and fungi are available. Basic and dye master mixes can be used with custom primers for PCR and real-time PCR analysis.

The latest development is a walk-away robotic system, SelectNA™plus, for the fully automated host DNA depletion and extraction of microbial DNA from clinical and other material. SelectNA™plus brings the utmost technical advances to the demands for contamination-free and low-hands-on processing of samples.

With SepsiTest™-UMD and Micro-Dx™, Molzym offers two CE-marked in vitro diagnostic solutions for the culture-independent detection of pathogens that cause various diseases. Both kits include reagents for the depletion of human DNA and the targeted isolation of microbial DNA from a variety of clinical samples, e.g. whole blood, CSF, BAL, joint aspirates, tissue biopsies, abscesses, and other specimens. Manual DNA isolation can be accomplished with SepsiTest™-UMD, and with Micro-Dx™ the process is fully automated on the SelectNA™plus robot. Precise detection is performed with broad-range 16S/18S PCR and sequencing analysis to identify the pathogens down to the species level. Both assays are especially applicable for samples that were negative after culturing, e.g. due to prior antibiotic treatment or fastidious growth requirements.

Service

Molzym offers customised manufacturing of master mixes decontaminated of microbial DNA for improved assay performance at increased amplification cycles.

The Molzym team appreciates your interest and is at your disposal for further information about our products and developmental issues.

Please call at: +49-421-69-61-62-0 or send your inquiries to info@molzym.com.