Enzymaster

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CZ VACCINES

La Relva s/n Torneiros 36410 O Porriño Spain Mercedes Rodriguez +34-986-330400 Mercedes.rodriguez@czvaccines.com https://czvaccines.com

I

500+ (Zendal Group) 1993

| Biotechnology | CDMO | Development | Manufacturing | Vaccines | Virus, bacteria, cell cultivation | Aerobes and anaerobes, yeast | Covid-19 vaccines | Tuberculosis vaccines | One-Stop Shop | Biomedicine | Aseptic filling | Lyophilisation | GMP upstream & downstream processes

11% revenue

Full-service biologics CDMO EU GMP certification

CZ VACCINES is a full service provider. We cover the entire value chain from contract development through clinical phases I to III to commercial production of vaccines and biological products.

CZ VACCINES is also collaborating on the urgent development of solutions against COVID-19 through our research and manufacturing capabilities in the following projects: › NVX-CoV2373 (NOVAVAX) › Vaccine DNA PPAL-COVID19 [Spanish National

Research Council (CSIC)] › Vaccine MVA-COVID-19(S) [Spanish National

Research Council (CSIC)] › Coalition for Epidemic Preparedness Innovations (CEPI) › Others projects

Scientific Excellence

CZ Vaccines has extensive scientific experience in developing new and ambitious projects that include different categories and vaccine platforms: › Human vaccines and animal vaccines › Against viral, bacterial, and parasite diseases › Conventional vaccines › Genetic engineering of live attenuated vaccines › Subunit vaccines (recombinant protein) › Latest generation DNA vaccines

End-to-End CDMO

› Live & inactivated bacteria & viral vaccines up to BSL-2 › Roller bottles, cell factory, & wave bioreactor › Single-use & stainless steel bioreactors › Sterile processing systems › Centrifugation, ultrafiltration, diafiltration › Chromatography (ÄKTA ready) › Aseptic filling into vials › Lyophilisation (clinical trial material and large scale) › Process development / optimisation › Quality control testing – microbiological: sterile/nonsterile, chemical-physical, and biological › Storage: (+2-8ºC), (-30ºC), (-80ºC)

Manufacturing capabilities:

CZ VACCINES has large manufacturing capacity located in several biotech plants in Spain and Portugal

cGMP Production capabilities: › Single-use bioreactors: 50L + 2x250L + 2x2000L › Stainless steel bioreactors: 50L + 250L+ 2x2000L › Single-use blending mixers: 2x 3000L › Stainless steel vessels: 4x6000L › State-of-the-art purification processes: chromatography (ÄKTA ready), centrifugation, ultrafiltration, diafiltration

cGMP fill & finish capabilities: › Liquid and lyophilised products up to BSL-2 › 4 filling machines: 6000 vials/hour - 2x12,000 vials/ hour – 24,000 vials/hour › 2 freeze dryers: up to 24,000 vials per run, and up to 180,000-200,000 vials per run › Component size: 2R-10R-20R › Manual & automatic visual inspection