B Medical Systems S.a r.l

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Further Collaborations ASKA Biotech GmbH

Veltener Str. 12 16761 Hennigsdorf Germany Anke Holzinger +49-3302-4941-430 info@aska-biotech.de https://www.aska-biotech.de

F LI Q

12 2018 S1; ISO 9001:2015

| Contract manufacturing | Expression and development of recombinant antibodies and proteins | Development and production of monoclonal antibodies | Cell line development and storage | Sample analysis of human sera and plasmas | Custom-production of ImmunoassayKits

| R&D units | IVD-, pharma and biotech-companies

Cooperations and partnerships for long-term business relationships.

ASKA Biotech GmbH is an independent and trusted contract manufacturing organization for the development and production of recombinant proteins and monoclonal antibodies. Customers from universities, research & development, in-vitro diagnostic (IVD) and preclinical fields benefit from our expertise. ASKA provides individual and flexible solutions for each customer requirement.

Our mission

We support our customers in their success. Our goal is to provide reliable services at competitive prices, to fulfill the specific requirements of our customers. With over 20 years of experience in cell culture, hybridoma development, downstream processing and immunoassay production, we are able to provide an excellent service in constant quality. All employees are specialists in their field, which enables ASKA Biotech to answer every inquiry in a short time with customized solutions. For this, we do not stop at the actual order, but think further and also advise our customers for the further process. Thus, every customer, regardless of the size of the company, benefits from our expertise.

Services

As an ISO 9001:2015 certified company, quality is from the beginning in ASKA’s focus as well as the supply of constant high-quality services and the customers’ satisfaction. Our services include, but are not limited to, the following areas:

ASKA’s rePro-Services: Within our rePro-Services ASKA expresses recombinant proteins and antibodies in mammalian cells. This can be realized transiently in HEK cells within weeks or via stable cell line development in CHO cells. Thanks to transient gene expression, we can perform several small-scale productions in parallel or produce up to several grams of recombinant antibodies in a few weeks.

ASKA’s monA-Services: Starting from mouse hybridoma development, ASKA Biotech develops the right antibody against the requested specific antigen. With further screening steps we are able to avoid cross reactivity or detect antibody-pairs. Starting from an already existing hybridoma clone ASKA Biotech produces monoclonal antibodies in small and large scale under serum-free conditions. We offer the option to dedicate the development and production of each antibody to our well-trained team with many years of experience. Alternatively, there is also the possibility to comply with customers protocol and specific needs for purification strategy, buffer, concentration, etc.

ASKA’s Immuno-Services: Our protein services are complemented by our sample analysis of human sera and plasmas and Immunoassaykit production services. ASKA Biotech offers you the entire range of services for development and production of immunoassays.

Additional Services: In addition, we offer several supplementary services such as cell line storage, aliquotation, protein polishing, diverse analytic methods, activity testing, lyophilization, and many more. Methods, which are not in our portfolio yet, can be established upon request.