YUMAB GmbH

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Collaborations Viscofan BioEngineering, a business unit of Naturin Viscofan GmbH

Badeniastraße 13 69469 Weinheim Germany Dr Lluís Quintana +49-6201-86-358 +49-6201-86-226 contact@bio.viscofan.com www.viscofan-bioengineering.com

I

14 2008

Development and manufacturing of collagen products for | regenerative medicine | biomedical R&D | nutraceuticals

| University of Tübingen (Germany) | University of Navarra (Spain) | Fraunhofer Institut IGB (Stuttgart, Germany) | Hospital Gregorio Marañón (Madrid, Spain) | FC Barcelona (Spain) | CELLINK (Sweden) | FILK Institute (Freiberg, Germany) | TriAnkle EU Project (Horizon 2020) | ARDAT Project (Innovative Medicines Initiative IMI-2) | VASCage GmbH (Austria)

Your partner for collagen in regenerative medicine

Viscofan BioEngineering is a business unit of Naturin Viscofan GmbH – the centre of excellence for collagen within the Viscofan group, a global leader in collagen production. Building on 85 years of experience in industrial-scale bovine collagen production for the food market, we use this extensive know-how to develop advanced solutions for the biomedical sector. The goal of our collagen portfolio is to facilitate cell biology research and to ultimately enable the development of novel therapies in regenerative medicine.

Unique collagen scaffolds for a wide range of applications

As an essential structural component of the extracellular matrix, collagen type I provides a scaffold to support cell attachment and function, as well as organ integrity. What sets our collagen matrices apart is firstly the intense yet gentle purification of insoluble collagen type I fibres, which preserves their native and complex structure, resulting in high biocompatibility and mechanical strength. Secondly, we shape the collagen fibre mass into customisable scaffolds with unique properties that are ideal for applications in tissue engineering, regenerative medicine, and medical device technologies.

› Collagen membranes as biodegradable cell support for tissue regeneration

Extruded to flat membranes, the dense network of long collagen fibres provides strength and flexibility to create versatile, biodegradable supports for tissue regeneration. For customisation, we adjust thickness, tensile strength, elasticity, biodegradation time, and other properties to optimally serve diverse applications such as advanced wound healing and urethra or hernia repair.

Our Collagen Cell Carrier® (CCC) is a native matrix for adherent primary cells, cell lines, and stem cells for in vitro and in vivo use. The standardised thin (20 µm) and elastic, yet strong membrane is especially suited as a biological vehicle for cell implantation.

An innovative tool for the development of ATMPs, its use as a stem cell-loaded cardiopatch for treatment of cardiomyopathy has justbeen evaluated in a phase I clinical trial.

› Viscolma® collagen mass for coating medical devices

As a smooth fibrous mass with concentrations of up to 15% collagen, Viscolma® can be used for individual research applications such as the development of 3D cell culture scaffolds. Moreover, the putty-like mass is especially suited for biocompatible coating of implantable medical devices.

› Soluble collagen for cell & tissue culture research

Our soluble collagen is used for thin coating of cell culture vessels and as a hydrogel for 3D cell and tissue cultures, promoting authentic cell performance.

Certified manufacturing – safe products

We start our production with traceable bovine raw material from New Zealand, a country with negligible BSE risk. Our collagen membranes and Viscolma® are provided both in R&D and medical grade quality, the latter manufactured in our GMP-compliant production unit. Viscofan BioEngineering is certified according to DIN EN ISO 9001 (Quality management systems) and DIN EN ISO 13485 (Medical devices – Quality management systems). This ensures the highest possible product safety for all medical products.

Enabling breakthroughs in regenerative medicine

Provided both in research and medical grade quality, our collagen products permit easy and cost-efficient bench-to-bedside transfer. Moreover, together with our partners, Viscofan BioEngineering is also developing its own pipeline of products in regenerative medicine. With the combination of premium products, our all-round know-how in collagen manufacturing, and expert customer support, Viscofan BioEngineering promotes new breakthroughs in medical development and is open to collaborations.