Clinical presentation of POMS Female to male ratio 1:1 in prepubertal presentation, increasing to 2:1 post-puberty Common symptoms are sensory, cerebellar, visual (ON), brainstem, pyramidal More frequent polyfocal presentation at onset 70% The 2017 McDonald criteria have good specificity of 95% and sensitivity of 71%.
Waldman A, et al. Neurology. 2016 Aug 30;87(9 Suppl 2):S74-81; Yeh EA, et al. Nat Rev Neurol.2009;5(11):621–31; Reinhardt K, et al. Eur J Neurol. 2014 Apr;21(4):654-9; Boesen MS, et al. Mult Scler. 2018 Jul;24(8):1077-1086
ON: optic neuritis; POMS: pediatric-onset multiple sclerosis
