Recommendations for DMT in POMS

International Pediatric Multiple Sclerosis Study Group

Prompt initiation of a first-line DMT with moderate efficacy

• Relapse rate is high in initial phases and correlated with a bad prognosis

• Brain tissue shows more active inflammation in childhood

• Despite the apparent clinical recovery from relapses due to better neuronal plasticity, cognitive impairment is frequent

• Postponing treatment may have a negative impact on social activities and school performance

Heterogeneities across Europe concerning treatment

Chitnis T, Tenembaum S, Banwell B, et al. Consensus statement: evaluation of new and existing therapeutics for pediatric multiple sclerosis. Mult Scler. 2012