Different acquired demyelinating syndrome presentations

Ms

Typical MS-based hyperintensities within the periventricular region, juxtacortical region, and in the cerebellum

Neuromyelitis optica spectrum disease (NMOSD)

Longitudinal extensive transverse myelitis involving the brainstem and extend over the entire cervical portion of the spinal cord

MOGAD,

Bilateral optic neuritis, optic nerve edema, contrast enhancement Cervical spinal cord lesion spanning over 2.5 vertebral levels

ADEM

Multiple, diffuse, ‘fluffy,’ poorly defined T2 hyperintense lesions involving both grey and white matter in supra- and infratentorial region

Jakimovski D, Awan S, Eckert SP, Farooq O, Weinstock-Guttman B. MS in Children: Differential Diagnosis, Prognosis, and Disease-Modifying Treatment , CNS Drugs. 2022