Diagnostic criteria for paediatric MS

One of the following is required

• ≥ 2 clinical CNS events (non-encephalopathic),with presumed inflammatory cause, separated by > 30 days and involving more than one CNS area

• One typical MS episode associated with MRI findings consistent with 2010 McDonald criteria for DIS and in a follow-up MRI with ≥ 1new enhancing or non-enhancing lesion consistent with DIT

• One ADEM attack followed by a non-encephalopathic clinical event, ≥ 3months after onset, that is associated with new MRI lesions that fulfill 2010 Revised McDonald DIS criteria.

• A first, single, acute event (e.g. a CIS)not meeting ADEM criteria and MRI findings are consistent with the 2010 McDonald Criteria for DIS and DIT (applied only to children ≥12 years old)

The presence of CSF specific oligoclonal bands can substitute for radiological evidence of DIT

Krupp LB, Tardieu M, Amato MP, et al. International pediatric multiple sclerosis study group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. Mult Scler. 2013; Alroughani and Boyko, Pediatric multiple sclerosis: a review, BMC Neurology (2018)