Diagnosis og CIS and MS in children

Evidence of dissemination of CNS inflammatory activity distributed in more than one CNS location (dissemination in space; DIS) and over time (dissemination in time; DIT)

Paediatric CIS, all of the following is required

• A monofocal or polyfocal, clinical CNS event with presumed inflammatory demyelinating cause

• Absence of a prior clinical history of CNS demyelination

Exclusion of MS mimics, particularly antibody mediated demyelinating diseases, infections, leucodystrodystrophies, inflammatory vasculopathies

• No encephalopathy (i.e. no alteration in consciousness or behavior) that cannot be explained by fever

• The diagnosis of MS based on baseline MRI features are not met

Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosisof multiple sclerosis: 2017 revisions of the McDonaldcriteria.Lancet Neurol2018; Alroughani and Boyko, Pediatric multiple sclerosis: a review, BMC Neurology (2018)