FRMC 2025 Program

THE FOUNDATION FOR REPRODUCTIVE MEDICINE CONFERENCE 2025 "THINK DIFFERENTLY."

*CE & CME Approved | Attendees can gain up to 20 AMA PRA Category 1 Credits™* *Program is subject to change*

DECEMBER 5-7, 2025 THE METROPOLITAN CLUB ONE EAST SIXTIETH STREET NEW YORK, NEW YORK

FRMC FOUNDATION FOR REPRODUCTIVE MEDICINE CONFERENCE (FRMC-2025) On Translational Reproductive Biology and Clinical Reproductive Endocrinology THE METROPOLITAN CLUB, NEW YORK CITY December 5-7, 2025

“THINK DIFFERENTLY”

WITH LEADING CLINICIANS AND RESEARCH SCIENTISTS FROM ALL OVER THE WORLD

TARGET AUDIENCES Medical students – free attendance; Residents, fellows, postdocs – discounted attendance.

Obstetricians & Gynecologists and Reproductive Endocrinologist & Infertility Specialists Reproductive Biologists and embryologists - discounted attendance Geneticists, Ethicists Fertility nurses, Nurse practitioners, Sonographers - discounted attendance Science journalists – free attendance Investors & administrators in the field Industry Lawyers

FRMC STATEMENT OF NEED • To demonstrate to clinicians in the field what ongoing bench research can contribute to better understanding of physiological processes relevant to clinical practice.

• To demonstrate to basic scientists in the field what the basic knowledge needs of clinicians are.

• To learn to “think differently” by critically assessing current clinical practice patterns in attempts to improve treatment outcomes.

PROGRAM OBJECTIVES • To present most up-to-date basic science as well as clinical knowledge to lead to a better understanding between basic scientists and clinicians in reproductive medicine.

• To demonstrate how improved cooperation between basic science and clinical medicine can improve patient care.

• To outline an alternative thinking pattern that allows for the critical evaluation of clinical practice patterns in their respective effectiveness.

Photo of Cumulus Oocyte Complexes

by David F. Albertini, PhD

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CONFERENCE VENUE Metropolitan Club One East Sixtieth Street New York, New York

CONFERENCE SPONSORS The Foundation for Reproductive Medicine (FRM) A Not-For-Profit Research Foundation 21 East 69th Street, New York, NY, 10021 T: (646) 882-0840, F: (212) 988-0250 www.foundationforreprodmed.com The Center for Human Reproduction (CHR) An International Fertility and Research Center 21 East 69th Street, New York, NY, 10021 T: (646) 882-0840, F: (212) 988-0250 https://www.centerforhumanreprod.com The International Do No Harm Group in IVF (IDNHG-IVF) A Not-For-Profit Foundation 21 East 69th Street, New York, NY, 10021 T: (646) 882-0840 F: (212) 988-0250

CONFERENCE ADMINISTRATION Trebron Management, Inc., New York, NY

CME ACCREDITATION ORGANIZATION To Be Announced

COMMERCIAL SPONSORS

FRMC A BRIEF INTRODUCTION TO THE FRMC-2025 In its usually mildly irreverent way, the FRMC will over three conference days again link evolving basic science with clinical practice, in the process facilitating translational progress between bench and clinic. The principal purpose of the conference is to demonstrate to clinicians what is possible and to inform basic scientists about what is needed. The intent is not to dream about the future, but to demonstrate what is possible now!

Starting with its first event in 2018, the FRMC, built its program around the motto, “think differently.” Consequently, the FRMC always offers materials not heard and/or seen elsewhere. To remain on the cutting edge of new developments, the conference content evolves slowly over the preceding year. With the human zygote being the ultimate stem cell for everything, a conference dedicated to reproductive clinical endocrinology and infertility as well as reproductive biology, of course, never lacks subjects of interest, and the FRMC has become internationally known for every year presenting a varying potpourri of interesting subjects, presented by leading experts from all over the world.

New York’s famous Christmas tree at Rockefeller Center – just a few blocks away from the conference venue the Metropolitan Club

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A BRIEF INTRODUCTION TO THE FRMC CONT. We are also pleased to announce what we consider to be long-overdue novelty at this year’s conference: In addition to selecting, as in past years, a Young Investigator Best Poster Award, starting this year, the conference will also every year honor at least one infertility patient with the newly established Foundation for Reproductive Medicine Award which will go to an infertility patient who has significantly contributed to progress in the infertility field.

Like every year, the conference is scheduled the weekend following the Thanksgiving weekend and just days after the lightening of New York City’s famous Christmas tree at Rockefeller Center. By moving the conference venue and headquarter hotel this year, moreover, literally only a few steps away from Rockefeller Center where the tree is located, the conference made this year an extra special effort not only - as is now widely acknowledged – in putting again together the year’s likely most interesting scientific conference in the field, but by also in giving attendees this year the opportunity to experience New York City in its most beautiful neighborhood at its most beautiful and special time of the year. ~ The Conference Chairs on behalf of the sponsoring organizations

CONFERENCE CHAIRS Eli Y. Adashi. MD, MS, MA Former Dean of Medicine and Biological Sciences, Professor of Medical Science, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Member of the National Academy of Medicine (formerly the Institute of Medicine), The Association of American Physicians and the American Association for the Advancement of Science. 2018 recipient of the ASRM Lifetime Achievement Award.

David F. Albertini, PhD, USA Editor-in-Chief Journal of Assisted Reproduction and Genetics (JARG), Chair: Reproductive Cell Biology Department, Bedford Research Foundation, Senior Visiting Scientist, The Center for Human Reproduction-New York, New York, N.Y., USA; Visiting Researcher, Stem Cell Biology and Molecular Embryology Laboratory, The Rockefeller University, New York, N.Y., USA Ali H. Brivanlou, PhD, USA Robert and Harriet Heilbrunn Professor, Director, The Brivanlou Laboratory of Synthetic Embryology, Rockefeller University New York, NY, USA.

FRMC CONFERENCE CHAIRS CONT. Eve Feinberg, MD Dr. Feinberg is a Professor at Northwestern University Feinberg School of Medicine and serves as the REI Fellowship Program Director and the Medical Director for Northwestern Center for Fertility and Reproductive Medicine. She is an Editorial Editor for Fertility and Sterility and is a co-host on the Fertility and Sterility On-Air podcast. Dr. Feinberg recently served a 3 year term as a Director at Large on the Executive Committee of the American Society for Reproductive Medicine. Dr. Feinberg is the founder and president of the Chicago Coalition for Family Building, a not for profit that awards grants for fertility treatment and adoption.

Norbert Gleicher, MD, USA Medical Director and Chief-Scientist, The Center for Human Reproduction, New York, NY, USA; Visiting Researcher, The Rockefeller University, New York, NY, USA; Professor (Adj.), Department of Obstetrics & Gynecology, University of Vienna Medical School, Vienna, Austria; President, The Foundation for Reproductive Medicine, New York, NY, USA. Raoul Orvieto, MD, Israel Professor and Head of Infertility and IVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat Gan, The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Israel; Co-Editor-in-Chief, Reproductive Biology and Endocrinology, Tel Aviv, Israel.

Pasquale Patrizio, MD, USA Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami, Miller School of Medicine, Miami, FL, USA; Visiting Scientist, The Center for Human Reproduction, New York, NY, USA.

Zev Williams, MD, PhD, USA Wendy D. Havens Associate Professor of Women’s Health and Chief of the Division of Reproductive Endocrinology and Infertility at Columbia University Irving Medical Center, and the Director of Columbia University Fertility Center, New York, N.Y., USA

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CONFERENCE FACULTY Eli Y. Adashi, MD, MS, MA, Former Dean of Medicine and Biological Sciences, Professor of Medical Science, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Member of the National Academy of Medicine (formerly the Institute of Medicine), The Association of American Physicians and the American Association for the Advancement of Science. 2018 recipient of the ASRM Lifetime Achievement Award.

David F. Albertini, PhD, Professor, Bedford Research Foundation, Bedford, MA, USA; Visiting Senior Scientist, The Center for Human Reproduction – New York, Editor-in-Chief, Journal of Assisted Reproduction and Genetics (JARG) and a Visiting Researcher at Rockefeller University, New York, USA Christine S. Allen, PhD, is a globally recognized expert in embryology and IVF laboratory operations and is a board member of several technology companies in the IVF field. She for the last eight years has served as Education Chair of the American Association of Bioanalysts (AAB) and is a current member of the ASRM Technology Committee.

Samuel F. Bakhoum, MD, PhD, is a world renown physician scientist in human oncology and pathogenesis and co-founder of the pharma start-up, Volastra Therapeutics, where he is Scientific Director and serves on the company’s board of directors. He is the recipient of several international research awards and has extensively published on chromosomal instability in malignant tumors.

David H. Barad, MD, MS, FACOG, Director of Clinical ART and Senior Scientist, The Center for Human Reproduction, New York, N.Y., USA. Angeline Beltsos, MD, is a reproductive endocrinologist who built from a single clinic a dominant network of IVF clinics in the Midwest, which she merged with a bigger national company where she for several years held senior clinical and administrative positions in the combined entity.

Ali H. Brivanlou, PhD, Robert and Harriet Heilbrunn Professor, Director The Brivanlou Laboratory of Synthetic Embryology Biology, Rockefeller University New York, N.Y., USA. Amander T. Clark, PhD, is Professor of Molecular Cell and Developmental Biology at UCLA and the Founding Director of the UCLA Center for Reproductive Science, Health and Education. She currently also serves on the National Academies of Science Engineering and Medicine Health Sciences Policy Board and is a Key Member of the UCLA Broad Stem Cell Research Center, Member of the Cell and Developmental Biology Home Area, Member of the Gene Regulation Epigenomics and Transcriptomics Home Area, Member of the Jonsson Comprehensive Cancer Center Cancer and Stem Cell Biology Program Area, Director of the Center for Reproductive Science, Health and Education.

Eve Feinberg, PhD, is a Professor at Northwestern University Feinberg School of Medicine and serves as the REI Fellowship Program Director and the Medical Director for Northwestern Center for Fertility and Reproductive Medicine. She is an Editorial Editor for Fertility and Sterility and is a co-host on the Fertility and Sterility On-Air podcast. Dr. Feinberg recently served a 3 year term as a Director at Large on the Executive Committee of the American Society for Reproductive Medicine.

Dr. Feinberg is the founder and president of the Chicago Coalition for Family Building, a not for profit that awards grants for fertility treatment and adoption.

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CONFERENCE FACULTY CONT. Allison Freeman J.D. is the lead attorney in the class action suits filled against PGT-A laboratories. She is located in Tampa, FL., USA Sonia Gayete-Lafuente, MD, PhD, is an MD, PhD, OBGYN, and REI (Reproductive Endocrinology and Infertility) specialist based in New York, originally from Barcelona, Spain, with many years of experience as a Gynecologist, Fertility Specialist, and as Clinical Researcher, with a robust background. From March 2021 to December 2023, she completed her Clinical Research Fellowship at Yale University's OBGYN Department, focusing on Fertility Preservation in young patients with cancer and conditions predisposing to ovarian insufficiency such as Turner Syndrome, completing her PhD and publishing several papers in Reproductive Endocrinology and Infertility during this time. Since January 2024, she has been a Clinical Research Fellow at the Foundation for Reproductive Medicine (FRM) at the Center for Human Reproduction (CHR) in New York. Here, she is engaged in both basic research studies on Reproductive Immunology and Embryology and clinical trials on advanced fertility treatments for complex infertile populations, aiming to develop evidence-based therapies in the field of Reproductive Medicine, New York, N.Y., USA. Norbert Gleicher, MD, FACOG, FACS, Medical Director and Chief Scientist, The Center for Human Reproduction – New York, President, The Foundation for Reproductive Medicine; Visiting Researcher Laboratory for Stem Cell and Molecular Embryology, The Rockefeller University, Prof. (Adj.), Department of Obstetrics and Gynecology, Vienna University School of Medicine, Vienna, Austria, Founding Editor-in-Chief Emeritus, Journal of Assisted Reproduction and Genetics (JARG) and American Journal for Reproductive Immunology (AJRI), New York, N.Y., USA Eriona Hysolli, PhD received her PhD from Yale University studying and enhancing the process of human iPSC reprogramming. She completed a postdoctoral fellowship in George Church's laboratory working on multiplex genome engineering for mammalian recoding and de-extiction, and subsequently became Head of Biological Sciences at Colossal, a company focused on de-extinction and conservation. She is currently co-founder and CSO of Manhattan Genomics, a company focused on applying gene correction technologies at the germline level to prevent genetic disease.

Chaim Jalas, PhD, is the CEO and Director of Technology Development at Juno Genetics U.S. in Brooklyn, N.Y., USA Robert J. Kiltz, MD, Founder and Director of CNY Fertility, one of the larger and structurally most innovative fertility clinic chains in the U.S., propagating a holistic medical approach for fertility treatments that is also “affordable.”

Antonio La Marca, MD, PhD, Professor of Obstetrics and Gynecology, Chair of the Obstetrics & Gynecology Department at the University Hospital of Modena, Director of the Residency Program in Ob&Gyn, University of Modena and Reggio Emilia; Editor-in-Chief of Minerva Obstetrics and Gynecology, Modena, Italy Milton K. H, Leong, MDCM, DSc (McGill), FACOG, FROG, FHKCOG, FHKAM, FRCS( C ), Clinic Director of the Women’s Clinic in Hong Kong and Professor, Mc Gill University, Montreal, Canada

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CONFERENCE FACULTY CONT. Sebastiaan Mastenbroek, PhD, is a researcher and expert in the fields of economics and public health, focusing on the intersection of healthcare systems, policy, and behavioral economics. His work aims to improve health outcomes through innovative approaches to healthcare delivery and policy-making.

Shoukhrat Mitalipov, PhD, Professor and Director of the Center for Embryonic Cell and Gene Therapy at Oregon Health & Science University (OHSU).

Cari Nicholas-Farrell, PhD, MS, doctoral and postdoctoral research studies were dedicated to the prevention, diagnosis and treatment of infertility focusing on various aspects of infertility. Her main career goal is to contribute to the improvement of fertility diagnostics and therapeutics. Currently, Dr. Nicholas-Farrell is the IVF Laboratory Supervisor for the Endocrinology, Andrology and Embryology departments at the CHR. In addition to her role as Supervisor, Dr. Nicholas-Farrell is a Senior Clinical Embryologist and a Reproductive Endocrinology and Infertility Scientist. Her long-term career goal to be an IVF Laboratory Director that collaborates with scientists and clinicians to conduct translational research using a bench to bedside approach to understand the underlying issues that contribute to reproductive disorders and find innovative ways to alleviate infertility, New York, N.Y., USA. Raoul Orvieto, MD, Professor and Head of Infertility and IVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat Gan, The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Israel; Co-Editor-in-Chief, Reproductive Biology and Endocrinology.

Pasquale Patrizio, MD, MBE, HCLD FACOG, Professor, Department of Obstetrics and Gynecology and Reproductive sciences, Director, Division of Reproductive Endocrinology and Infertility, University of Miami School of Medicine, Miami, Florida, USA; Visiting Senior Scientist, The Center for Human Reproduction, New York, N.Y., USA Vardit Ravitsky, PhD, is President and CEO of the Hastings Center, an independent, nonpartisan bioethics research institute that is among the most prestigious bioethics and health policy institutes in the world. She is a full professor at the Bioethics Program, School of Public Health, University of Montreal and currently Senior Lecturer on Global Health and Social Medicine at Harvard Medical School. She is also the immediate Past-President of the International Association of Bioethics and a Fellow of the Canadian Academy of Health Sciences. Her research focuses on the ethics of genomics and reproduction, as well as the use of AI in biomedical research, and is funded

by Canada’s leading funding agencies and the NIH. Nicolas Rivron, PhD, Group Leader, Laboratory for Synthetic Development, Institute of Molecular Biotechnology, the Austrian Academy of Sciences (IMBA)/ the Vienna BioCenter (VBC), Vienna, Austria Jaime A. Roura Monllor, MD, MS, is a board-certified obstetrician gynecologist and a current reproductive endocrinology & infertility fellow at the University of North Carolina at Chapel Hill. He holds a master’s degree in statistics and completed a postdoctoral fellowship in molecular biology focused on uterine fibroids. His work on preimplantation polygenic risk scoring is a collaboration with the multidisciplinary Polygenic Embryo ELSI Research Group.

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CONFERENCE FACULTY CONT. Zeev Shoham, MD, is a full professor at Hadassah Medical School, affiliated with the Hebrew University of Jerusalem, Israel. He is a leading authority in reproductive medicine and infertility and until recently he served as the Director of the Fertility and IVF Unit at Kaplan Medical Center in Rehovot, Israel.

With a career spanning several decades, Professor Shoham has published over 160 peer-reviewed articles in the field of reproductive medicine. He is internationally recognized for pioneering the protocol of double ovarian stimulation, a groundbreaking approach in IVF, particularly beneficial for poor ovarian responders.

Professor Shoham is also the co-editor of the widely acclaimed textbook Assisted Reproductive Techniques, a foundational resource used by clinicians and researchers worldwide. Beyond his academic and clinical contributions, he is the co-founder of IVF-Worldwide.com, the largest global platform for IVF clinics and professionals. This initiative promotes collaboration, disseminates cutting-edge research, and conducts global surveys on ART practices, significantly advancing evidence-based fertility care.

Through his leadership and innovations, Professor Shoham has played a central role in shaping modern IVF practice and uniting the global reproductive medicine community.

Mitchell Stern, Managing Director and Head of the Healthcare Group at Dresner Partners. is the leading investment banker in the fertility (IVF) sector having been involved in over 16 IVF clinic, third party reproduction and fertility lab sales worldwide, including the sale of IGENOMIX, the merger of RMANJ and IVI of Spain, the sale of Advanced Fertility of Chicago to Prelude Fertility (now Inception), the sale of Santa Monica Fertility to Webster Equity Partners, the sale of InVia Fertility to In Vitro Sciences (now First Fertility), the sale of Institute for Human Reproduction to Pinnacle Fertility, the sale of Dominion Fertility to Pinnacle Fertility, the sale of Center of Reproductive Medicine to US Fertility, the sale of IVF1 to Pinnacle Fertility, the sale of Fertility Institute of New Jersey & New York to Axia Women's Health, the sale of RADfertility to CCRM, the sale of The Advanced IVF Institute to CCRM, the sale of Conceptions Reproductive Associates of Colorado to IVIRMA Global, the sale of Reproductive Science Center of New Jersey to Inception Fertility, and the sale of Overlake Reproductive Health.

Mark W. Surrey, MD, is a reproductive endocrinologist and reproductive endoscopic surgeon in private practice and the Medical Director of SCRC (Southern Cal Reproductive Center) in Los Angeles, CA. Min Yang, PhD, is a former joint postdoc of the Brivanlou Laboratory at Rockefeller University and The Center for Human Reproduction, both in NYC. She now is an Assistant Professor of Obstetrics & Gynecology at the Institute for Stem Cell & Regenerative Medicine at the University of Washington in Seattle, where she leads her own research laboratory.

Andrea Weghofer, MD, PhD, MBA is a reproductive endocrinologist and associate professor at the Vienna University School of Medicine in Vienna, Austria and a Visiting Scientist at the CHR in NYC. Zev Williams, MD, PhD. Director, The Wendy D. Havens Associate Professor of Women’s Health and Director of Columbia University Fertility Center, New York, NY.

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CONFERENCE FACULTY CONT. MORE SPEAKERS TO BE ANNOUNCED SOON.

FRMC DAY 1: Friday, December 5, 2025 Welcome 08:30 - 08:40

The Young Investigator Best Poster Award David F. Albertini, PhD

08:40 - 08:45

The Foundation for Reproductive Medicine Patient Award Norbert Gleicher, MD

Session 1: Breaking Ethical, Clinical, and Legal Issues Chair: Norbert Gleicher, MD

08:45 - 09:30

The Opening Lecture: Preimplantation Polygenic Risk Scoring: Current Status and Potential for Embryo Selection Jaime A. Roura-Monllor, MD, MS

09:30 - 10:00

The Do-No-Harm in IVF Group Lecture: Fixing – instead of discarding - embryos through genomic editing with CRISPR to prevent genetically inherited diseases – ethics and practicability Eriona Hysolli, PHD

10:00 - 10:30

The ethics of egg sharing Eve Feinberg, MD

10:30 - 11:00

Factually incorrect publications regarding preimplantation genetic testing for aneuploidy are continuing to affect clinical IVF practice: The claim that PGT-A in older women improves IVF outcomes as an example

David H. Barad, MD, MS

FRMC 11:00 - 11:30

Why we decided to sue the PGT-A industry Allison Freeman J.D.

11:30 - 12:00

Coffee Break

Session 2: Important New Potential Clinical Developments Chair: Eve Feinberg, MD

12:00 - 12:30

12:30 - 13:00

13:00 - 13:20

The Foundation for Reproductive Medicine Lecture: Translating important basic reproductive biology research into clinical IVF progress Nicolas Rivron, PhD

Advancing the accuracy of ovulation trigger timing for highly individualized Oocyte Retrieval (HIER) with a sonographic phenotype denoting follicle maturity at all follicle sizes Norbert Gleicher, MD

Grab your lunch and return to your seats for the Day 1 Symposium

FRMC Symposium: Do embryos really self-correct and, if so, how?

Initially demonstrated in a mouse model and more recently in the human experience and in stem cell lines, the fact that embryos even post blastocyst stage can still self-correct is still disputed. We invited several experts to offer their opinions

13:20 - 14:00

Chair: David H. Barad, MD, MS Panelist: Raoul Orvieto, MD Panelist: Pasquale Patrizio, MD, MBE Panelist: David F. Albertini, PhD Panelist: Chaim Jalas, PhD Panelist: Min Yang, PhD

Session 3: About the Clinical Future of IVF Chair: Pasquale Patrizio, MD, MBE

14:00 - 14:30

Can we delay ovarian aging: The Columbia University Rapamycin Trial to delay menopause Zev Williams, MD, PhD

14:30 - 15:00

The negative effects of practice changes in FET cycles on national pregnancy and live birth rates Sonia Gayete-Lafuente, MD, PhD

15:00 - 15:30

Individualized in vitro maturation of oocytes to maximize embryo yield and the importance of patient age.

Cari Nicholas-Farrell, PhD, MS

15:30 - 16:00

Coffee Break

FRMC Session 4: About the Future of Reproductive Biology and Infertility Chair: Zeev Shoham, MD

16:00 - 16:30

Building the primate ovary from scratch – insights into human fertility Amander Clark, PhD

16:30 - 17:00

Where Elon Musk could get us to, if he only were interested in reproductive medicine Eli Y. Adashi, MD, MS, MA

17:00 - 17:30

Haven’t we spent enough effort, time, and money on the hypothesis of embryo selection?

David F. Albertini, PhD

17:30 - 18:00

Whose child is she/he? The genetic gestation-divide Vardit Ravitsky, PhD

18:00 -18:15

The Daily Summary - Q&A with the day’s faculty

18:15 - 21:00

Welcome Reception

FRMC DAY 2: Saturday, December 6, 2025 Session 5: Driving Towards Precision Medicine in Reproductive Endocrinology and Fertility - Part I Chair: David F. Albertini, PhD

08:30 - 09:00

A diapause-like response in human blastocysts following mTOR inhibition and its possible clinical relevance for IVF Nicolas Rivron, PhD

09:00 - 09:30

Are there still infertility patients in whom PGT-A may be indicated?

Sebastiaan Mastenbroek, PhD

09:30 - 10:00

Why current IVF practice favors IVF clinic interests at the costs of patient interests: The need for Precision Medicine in place of routine protocols.

David H. Barad, MD, MS

10:00 - 10:30

Why the individualized ovulation trigger is of such importance Raoul Orvieto, MD

10:30 - 11:00

Coffee Break

Session 6: Driving Towards Precision Medicine in Reproductive Endocrinology and Fertility - Part II Chair: Nicolas Rivron, PhD

FRMC 11:00 - 11:30

The Center for Human Reproduction Lecture: On the way to in vitro gametogenesis Shoukhrat Mitalipov, PhD

11:30 - 12:00

Preparing ovaries for maximal efficiency: Why are androgen and growth hormone supplementations in selected patients still controversial?

Norbert Gleicher, MD

12:00 - 12:30

Some interesting news on embryo culture media Sebastiaan Mastenbroek, PhD

12:30 - 13:00

Lunch

13:30 - 14:00

Symposium: The Scientific and economic future of the fertility field With the almost completed retirement of the first generation of IVF practitioners, the switch from a predominantly malemedical specialty to an almost uniformly female medical specialty, colossal investments by Private Equity into the specialty, formation of national and even international practice chains, and clearly speeded up pace for change in all of medicine, considering the future of REI appeared like an appropriate theme for a symposium.

Chair: Norbert Gleicher, MD Panelist: Eli Y. Adashi, MD, MS, MA Panelist: Andrea Weghofer, MD, PhD, MBA Panelist: Milton Leong, MD Panelist: Robert J. Kiltz, MD Panelist: Pasquale Patrizio, MD, MBE

FRMC Session 7: The Future of the Business of Infertility Chair: Milton Leong, MD

14:00 - 14:30

The impact of worldwide quickly declining non-physician ownership of IVF clinics on clinical practice Pasquale Patrizio, MD, MBE

14:30 - 14:50

Having merged a local clinic network into a larger national network, what I have learned?

Angeline Beltsos, MD

14:50 - 15:10

Having sold my practice to a Private Equity-owned clinic network, what has been my experience?

Mark Surrey, MD

15:10 - 15:30

What you need to know when you are thinking about selling your IVF clinic to a network Mitchell Stern

15:30 - 16:00

Coffee Break

Session 8: Interesting News in the Research Arena Chair: Eli Y. Adashi, MD, MS, MA

16:00 - 16:30

The pool of recruitable antral follicles is modifiable, and I can tell you how Antonio La Marca, MD, PhD

FRMC 16:30 - 17:00

Why is nobody talking about the fact that clinical pregnancy and live birth rates in autologous IVF have since 2010 steadily declined Norbert Gleicher, MD

17:00 - 17:30

A year later with A.I.: Where we are, - and how to do no harm with it?

Christine S. Allen, PhD

17:30 - 18:00

How the CHR between 2023 and 2024 improved ongoing clinical pregnancy rates from 8% to 12% in poorestprognosis patients (medial age 44-45) with at least one transferrable cleavage-stage embryo: Making tested out “mini-steps.”

Sonia Gayete – Lafuente, MD, PhD

18:00 -18:30

The Daily Summary - Q&A with the day’s faculty

FRMC DAY 3: Sunday, December 7, 2025 Session 9: What We May Want to Reconsider in Clinical IVF Practice Chair: Sonia Gayete – Lafuente, MD, PhD

08:30 - 09:00

The Oocyte Revolution - where will they come from next?

Cari Nicholas, PhD

09:00 - 09:30

Are we suffering from “freezing mania”?

Antonio La Marca, MD, PhD

09:30 - 10:00

The PCOS patient everybody overlooks and, therefore, underestimates in prevalence Norbert Gleicher, MD

10:00 -10:30

Coffee Break

Session 10: The Latest News at the Latest Hour Chair: Norbert Gleicher, MD

10:30 - 11:00

Resilient by design: Why and how the placenta survives genomic chaos Min Yang, PhD

FRMC 11:00 -11:30

To Be Determined

11:30 - 12:00

To Be Determined

12:00 - 12:30

Differentiating non-invasively between meiotic and mitotic aneuploidies in human embryo models and human embryos Ali H. Brivanlou, PhD

12:30 - 13:00

The Closing Lecture: To Be Announced Sam Bakhoum, MD, PhD

On behalf of the entire FRM organization we thank you for your support and participation in our annual conference.

We hope that this year’s conference helps you to

“THINK DIFFERENTLY“