Pterostilbene powder: 37 FAQ about Pterostilbene Benefits,Dosage,Side Effects 1. What is Pterostilbene?............................................................................................... 2 2. What is Pterostilbene powder?..................................................................................3 3. What is Pterostilbene mechanism of action?............................................................ 4 4. What is Pterostilbene use for?................................................................................... 5 5. What are the benefits of taking Pterostilbene?......................................................... 5 1) Pterostilbene benefits in cardiovascular health.................................................5 2) Pterostilbene benefits in Alzheimer’s disease................................................... 5 3) Pterostilbene may improve cognition................................................................ 6 4) Pterostilbene is a powerful anti-inflammatory.................................................. 6 5) Pterostilbene may help weigth loss................................................................... 6 6) Pterostilbene improve heart function................................................................7 7) Pterostilbene protect features to vision............................................................ 7 6. What are the benefits of Pterostilbene for skin?....................................................... 7 7. Is Pterostilbene good for the brain?...........................................................................7 8. Is Pterostilbene good for weight loss......................................................................... 8 9. Pterostilbene benefits for hair growth.......................................................................8 10. Pterostilbene dosage................................................................................................9 11. Pterostilbene side effects....................................................................................... 10 12. Pterostilbene for anxiety........................................................................................ 11 13. Pterostilbene for fertility........................................................................................ 11 14. Pterostilbene for dogs............................................................................................ 12 15. What foods contain Pterostilbene?........................................................................14 16. What is Pterostilbene derived from?..................................................................... 14 17. Pterostilbene natural sources................................................................................ 15 18. Is Pterostilbene a phytoestrogen........................................................................... 15 19. Is Pterostilbene fat soluble.....................................................................................15 20. Is Pterostilbene water soluble?.............................................................................. 15 21. Does Pterostilbene increase LDL?.......................................................................... 16 22. Does Pterostilbene lowder blood pressure?.......................................................... 16 23. Is Pterostilbene dangerous.....................................................................................17 24. How much Pterostilbene should I take?.................................................................17 25. Pterostilbene with or without food?......................................................................17 26. Should you take Pterostilbene?..............................................................................18 27. What is the best time of day to take Pterostilbene?..............................................18 28. What supplements contain Pterostilbene?............................................................18 29. Is Pterostilbene better than Resveratrol?.............................................................. 19 1). What is Resveratrol......................................................................................... 19 2). Pterostilbene vs Resveratrol............................................................................20 -A Comparison of Bioavailability and Health Benefits................................. 20 -Structural Differences................................................................................. 21
-Bioavailability and Half-life..........................................................................22 -Comparison of Health Benefits................................................................... 23 30. Who should not take resveratrol............................................................................24 31. How much resveratrol is safe?............................................................................... 25 32. Pterostilbene with caffeine.................................................................................... 25 33. Pterostilbene with quercetin..................................................................................25 1) What is quercetin and its benefits........................................................... 25 2) Pterostilbene vs Quercetin.......................................................................26 34. Pterostilbene vs berberine..................................................................................... 26 35. Pterostilbene and NMN..........................................................................................27 1) What is NMN.................................................................................................... 27 2) Pterostilbene with NMN.................................................................................. 28 36. Pterostilbene and Nicotinamide riboside...............................................................29 1) What is Nicotinamide riboside(NR)..................................................................29 2) Pterostilbene with Nicotinamide riboside(NR)................................................ 29 37. Where to buy Pterostilbene?................................................................................. 29 Pterostilbene is say better than resveratrol. They call it dragon’s blood, or ev en the fountain of youth. Do you want to know more about Pterostilbene? H ere are the 37 FAQ you need to know:
1. What is Pterostilbene? Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a naturally occurring pol yphenol, a type of molecule that occurs in plants. It is part of the stilbene g roup of compounds and the main antioxidant component of blueberries. In pl ants, it serves a defensive antimicrobial and often antioxidative role. Pterostilbene was first discovered in 1977 by Langcake and Pryce and has be en studied for its antioxidant properties and potential health benefits. Pterostilbene is chemically related to resveratrol, another popular dietary supp lement; some studies suggest that it may be more useful for health than its close relation, sometimes giving rise to the suggestion that it may be a “bet ter resveratrol”. The main benefits of Pterostilbene can be summarized as follows: 1
Pterostilbene is a natural substance found in small quantities in vegeta bles and fruits such as blueberries.
2
Pterostilbene is a small molecule that is better than resveratrol in ter ms of absorption and stability.
3
Pterostilbene extended lifespan in various organisms.
4
Pterostilbene can reduce inflammation.
5
Pterostilbene can improve DNA repair.
6
Pterostilbene can activate sirtuins, which are enzymes that repair DNA, improve metabolism and can extend healthspan and lifespan.
7
Pterostilbene can improve brain functioning and can protect the brain.
8
Pterostilbene can reduce protein accumulation, which is one of the dri vers of aging.
9
Pterostilbene activates AMPK, an important enzyme that can protect c ells against aging.
10
10. Pterostilbene increases the production of powerful antioxidant enzy mes, protecting the cells against oxidative damage.
2. What is Pterostilbene powder? Pterostilbene powder is the raw material of Pterostilbene with white colour. Pterostilbene powder (537-42-8) Base Information Name
Pterostilbene powder
CAS number
537-42-8
Purity
98%
Chemical name
Pterostilbene（Dimethylresveratrol）
Synonyms
3,5-Dimethoxy-4-stilbenol, 3,5-Dimethoxy-4-hydroxy-E-stilbe ne
Molecular Formula
C16H16O3
Molecular Weight
256.3 g/mol
Melting Point
89-92 °C
InChI Key
VLEUZFDZJKSGMX-ONEGZZNKSA-N
Form
White powder
Half Life
Solubility
Storage Condition
protect from light, 2-8°C
Application
Pre-workout, bodybuilding supplements,cosmetics
COA,HPLC
Available
Pterostilbene powder
3. What is Pterostilbene mechanism of action? Pterostilbene is a polyphenol, a type of molecule that occurs in plants, partic ularly small berries and nuts. Blueberries are a particularly rich source of pter ostilbene; although it is found in grapes, pterostilbene (unlike its cousin resver atrol) doesn’t survive the wine-making process. What’s a polyphenol? “Phenol” refers to a certain chemical structure (in thi s case, a hydroxyl group linked to a benzene ring); “poly” just means the molecules have more than one of the structure. One of polyphenols’ main j obs is to help the plant fight off pathogens. When eaten by humans, polyph enols may serve as powerful antioxidants. Scientists have been aware of phenols since the early 19th century — Joseph Lister, the pioneer of antiseptic surgery, reported on one phenol’s disinfecta nt properties in 1867 — though the term “polyphenol” didn’t have its fir st recorded use until 1894. As with the rest of polyphenols, researchers don’t fully understand how pter ostilbene works. Dr. Jose M. Estrela, a professor of physiology at the Universit y of Valencia (Spain) who has studied pterostilbene says "the good thing is t hat pterostilbene works, but the bad thing is that we cannot fully explain its
potential health benefits with the information that we have.”
4. What is Pterostilbene use for? Pterostilbene may help protect against Alzheimer's disease and aging-related c ognitive decline, according to an animal-based study published in Neurobiolog y of Aging in 2012. In tests on mice, the study's authors determined that pt erostilbene may help preserve cognitive function, in part by reducing inflamm ation.
5. What are the benefits of taking Pterostilbene? The multiple benefits of pterostilbene in the treatment and prevention of hu man disease have been attributed to its antioxidant, anti-inflammatory, and an ticarcinogenic properties leading to improved function of normal cells and inhi bition of malignant cells. Various studies have demonstrated the antioxidant, anti-inflammatory , and an ticarcinogenic properties of pterostilbene, which has led to the improved func tion of healthy cells and the inhibition of malignant cells.
1) Pterostilbene benefits in cardiovascular health Pterostilbene has been implicated in cardiovascular health. with one study sho wing that it has a protective effect against atherosclerosis and another showi ng that it improves aspects of autophagy and helps to counteract the pro-ath erosclerosis effect of oxidized low-density lipoprotein on vascular endothelial c ells . It has also demonstrated potential utility in treating ischemia-reperfusion injury.
2) Pterostilbene benefits in Alzheimer’s disease Studies have also shown the potential of pterostilbene in relation to neurode
generative conditions such as Alzheimer’s disease. A study on mice with accel erated aging showed that pterostilbene, even in low doses, has a significant e ffect on improving cognitive ability.
3) Pterostilbene may improve cognition Another study suggests that pterostilbene is involved in neural plasticity and i ts associated cognitive and motor functions and that rats given pterostilbene perform better in cognitive tests.
4) Pterostilbene is a powerful anti-inflammatory Pterostilbene is a powerful anti-inflammatory and can suppress NF-Kb, a prote in complex that regulates the transcription of DNA, cytokine production and c ell survival. A recent study showed that pterostilbene can potentially treat sev ere acute pancreatitis by reducing serum levels of inflammatory TNF-a, IL-1b, and NF-kB and that it reduces the generation of reactive oxygen species. Pterostilbene also has some data that suggests it might be useful for treating arthritis, and given its anti-inflammatory properties, this is hardly a surprise. While research is limited to date regarding arthritis, a rat study did suggest s ome potential for treating this condition.
5) Pterostilbene may help weigth loss A recent study performed on patients with hypercholesterolemia, not taking a nti-cholesterol medications, found that when supplemented with Pterostilbene, these test subjects showed a significant amount of weight loss. This points t owards the potential weight loss benefit of the chemical compound. Another study performed on animal models supplemented with Pterostilbene powder showed a significant increase in the Akkermansia muciniphila populat ion in the gut of the animal models. The importance of this species is that i t reduces the risk of obesity, and improves the overall health of the gut.
6) Pterostilbene improve heart function The antioxidant features of Pterostilbene are especially beneficial in the heart, as they reduce the oxidative stress on the organ. Studies on animal models have shown a significant reduction of pulmonary heart failure, which is cause d by stress on the heart by the dysfunction of the lungs.
7) Pterostilbene protect features to vision Currently, there are several studies focusing on the ability of this polyphenol i n minimizing the incidence of blindness in diabetic patients. The need for this study was raised as a result of another study that proved that Pterostilbene reduces inflammation in the cornea. This finding has led to researchers push ing for the use of Pterostilbene powder for the treatment of dry eye.
6. What are the benefits of Pterostilbene for skin? Pterostilbene cream which contain Pterostilbene powder was highly effective i n reducing markers of aging and induces even skin tone. The product was eff ective in reducing wrinkles and fine lines, improved skin hydration elasticity a nd showed no adverse effects
7. Is Pterostilbene good for the brain? Yes, Pterostilbene is good for the brain. Pterostilbene can improve brain funct ioning and can protect the brain. Pterostilbene can reduce protein accumulati on, which is one of the drivers of aging. Pterostilbene activates AMPK, an im portant enzyme that can protect cells against aging.
8. Is Pterostilbene good for weight loss Pterostilbene has produced positive results for weight loss in at least one stu dy, but larger and more robust studies are required to confirm its effectivene ss. In a study of middle-aged people with high cholesterol, those who were not taking cholesterol medication lost a small, but significant, amount of weight w hile supplementing with pterostilbene. This result was somewhat surprising, as this study was not designed to measure pterostilbene as a weight loss aid. This result has not yet been investigated in a separate study. Cell and animal studies also suggest that pterostilbene may help improve insu lin sensitivity. Pterostilbene blocks the conversion of sugars into fats and prev ents fat cells from multiplying. Pterostilbene may also change the composition of the gut flora, the colonies of microbes that live in the intestine and help digest food. Rats fed pterostilbene had healthier gut flora, including a significant increase i n Akkermansia muciniphila, a species of bacteria that appears to prevent obes ity, diabetes, and low-grade inflammation. A. muciniphila has recently become a focus of probiotic research; future studies will clarify whether and how pt erostilbene supports its growth.
9. Pterostilbene benefits for hair growth A healthy, nutritious diet is key to a healthy head of hair. Filling up with foo ds that are rich in protein and vitamins will help improve the look of your s kin and improve your health overall, and of course, keep an eye out for resv eratrol or Pterostilbene. If it's hair loss you're currently concentrating on, you might want to introduce supplements into your routine. Supplement which c ombine of minerals and vitamins that nourish the scalp and help support hea lthy-looking hair.
Here are some more things you can do to nurture you and your hair: -Scalp massage A good scalp massage can help release tension around the crown of the hea d, and not only does it feel good, research indicates that if you do it regular ly, you might also experience thicker hair. Great, if you're struggling with alop ecia, scalp massaging focuses on the hair follicle, which is found just below t he skin's surface. When these follicles are stimulated, the blood vessels are d ilated and hair growth (potentially) happens. Massage your scalp a couple of times a week in the shower to help boost t he look of your hair and help you relax. Or use it to work in your favorite hair serum or foam to help spread the product and aid with absorption and blood flow. -Reduce Stress. The world can be a difficult place, and unfortunately, if you find yourself und er an enormous amount of stress, you could also see more hair loss than us ual. (As if things aren't tricky enough!) Stressors come in all shapes and sizes — perhaps you're dealing with difficult work conditions, or maybe you're livi ng with financial complications. Whatever it is, if you don't find time to unwi nd properly, you could experience physical side effects. Telogen effluvium is the type of hair loss most associated with stress. You co uld also experience Alopecia areata (hair loss in specific areas), Trichotillomani a (hair-pulling) and Androgenic alopecia (thinning hair). Ensure you're eating well and work on your sleep hygiene to encourage a flow state and deep res t.
10. Pterostilbene dosage Supplementation of pterostilbene for the purpose of aiding glucose and lipid metabolism tends to be around 20- 40mg/kg oral ingestion in rats, which is an estimated human dosage range of: 215-430mg for a 150lb person
290-580mg for a 200lb person 365-730mg for a 250lb person Possible anxiolytic properties of pterostilbene are seen at 1-2mg/kg in mice, which is an estimated human dose of: 5.5-11mg for a 150lb person 7.3-14.5mg for a 200lb person 9-18mg for a 250lb person Which is notable as 5-10mg/kg in these mice (slightly over double the dose) has failed to have the same anxiolytic effects, suggesting a bell-curve that ma y favor lower dosages such as is found in food consumption rather than high er dosages from supplementation. Limited human studies have used either 50mg twice a day or 125mg twice a day, and the addition of Grape seed extract (100mg at both dosing times) with the low dose may mitigate some adverse effects on cholesterol seen wit h pterostilbene in isolation.
11. Pterostilbene side effects Compared to medications that are prescribed to treat symptoms like high cho lesterol and other common health problems, pterostilbene is much less likely to cause side effects (such as muscle pain and nausea). It is generally safe to consume from both foods and supplements, but in high doses it may interfe re with the effects of certain medications. If you take medications to help control your cholesterol, blood pressure and/o r blood glucose levels, it’s best to speak with your doctor first before begin ning any new supplements. Your doctor can help to monitor your reaction if you choose to start taking pterostilbene in order to make sure your dosage d oesn’t need to be adjusted.
Even when taken in high doses, pterostilbene has been found to be generally non-toxic. However, high doses do not seem to offer additional benefits, whi ch is why you should follow dosage recommendations, and according to the r esearch published in the Journal of Toxicology, “the potential for toxicity can not be excluded at higher doses.” Stop taking pterostilbene supplements if you experience nausea, aches, hives or any unusual symptoms. If you have al lergies to pterostilbene foods like berries, peanuts or grapes, you should avoi d eating these foods even if they are otherwise considered “healthy.”
12. Pterostilbene for anxiety Pterostilbene is an extract from blueberries, so it acts as a strong anti-oxidan t. It controls or helps to balance nerve signals and chemistry in the hippoca mpus, which in turn controls memories. Pterostilbene helps reallocate thought s and memories as "not-stressful," making you feel more relaxed. You can tak e these Pterostilbene supplements every day.
13. Pterostilbene for fertility A woman’s eggs are made while she herself is in utero. As those eggs get older, their DNA becomes fragile and more prone to chromosomal damage. This chromosomal damage is the leading cause of pregnancy loss across all a ge groups, and the risk of miscarriage increases as one gets older. Age is t he number one factor affecting a woman’s fertility. Pterostilbene is a potent antioxidant that have been seen help with egg quali ty. It’s very easy to take and never had a patient report any side effects. Resveratrol is an antiaging, antioxidant, anti‐inflammatory, and insulin‐sensitizin g natural polyphenolic compound. Growing evidence indicates that resveratrol has potential therapeutic effects in infertile women with diminished ovarian fu nction, polycystic ovary syndrome (PCOS), or endometriosis.
Beside use Pterostilbene or Resveratrol supplements, a good lifestyle is good f or fertility also. For example: -Sleep The more we learn about sleep, the more we discover that eight or more h ours each night is needed for optimal health. This is especially true for our eggs. Our bodies are designed to wake up with the sun and go to sleep w hen it gets dark. Getting enough sleep is key for hormonal balance, which i n turn supports healthy egg development. Sleep also plays a critical role in maintaining optimal weight, promoting good energy levels, and reducing stres s. -Exercise Some exercise is good, but too much can work against you when you want t o be pregnant. The body has two gears: Fight-or-flight Feed-and-breed Strenuous exercise puts the body into the fight-or-flight mode. This impacts your hormones, suppresses egg development, and makes it harder to get pre gnant. Mild to moderate exercise, think walking or gentle yoga, keep your blood circulating while maintaining your body in the feed-and-breed mode.
14. Pterostilbene for dogs Compare to the information about Pterostilbene for dogs, more information is about Resveratrol for dogs. A study conducted in 2015 found that resveratrol both boosts and suppresses the immune system. Resveratrol prompts the whit e blood cells to release more pro-inflammatory cytokines than usual. White bl ood cells use these cytokines to communicate with each other when fighting infection. The more cytokines there are, the stronger the immune system. However, resveratrol simultaneously suppresses the immune system by decreas ing the function of neutrophils. These white blood cells fight and kill bacteria during an infection. These conflicting findings make it even more difficult to determine whether resveratrol truly benefits the immune system.
The compound may also prevent cancer, particularly colon and breast cancers, by preventing and slowing the growth of cancer cells. Resveratrol also has a ntihypertensive properties, and may prevent high blood pressure and cholester ol. It is also thought to promote neurological health, although this has not b een confirmed. Some studies suggest it may increase an animal’s lifespan. While these findings seem promising, veterinarians are still investigating the f ull effects of resveratrol on the canine immune system. It is unclear whether prolonged administration of resveratrol supplements poses any harm to dogs and other animals. More research is needed to determine the side effects of the compound, not just in dogs but in all animals. Additionally, nearly all the studies that suggest resveratrol is mostly beneficial were conducted on cultured cells, fruit flies, fish, and mice. Though studies show that resveratrol increases these animals’ lifespans, resveratrol will most likely affect dogs differently. There are few studies on the effects of resveratr ol in dogs. Many studies remain optimistic about the health benefits of resveratrol for bo th canines and humans. However, it may not be the miracle supplement som e sources claim it is. Most healthy dogs will not require resveratrol supplementation, especially sinc e resveratrol should be administered in very small amounts. If you want to a dd a little extra resveratrol to your dog’s diet, consider feeding them bluebe rries or peanuts. Both foods contain naturally-occurring resveratrol, in addition to vitamins, minerals, and heart-healthy antioxidants. Never administer any supplements to your dog unless explicitly instructed to do so by a veterinarian. If you believe your dog may benefit from a resveratr ol supplement, ask your veterinarian about the benefits and complications bef ore purchasing any supplements or changing your dog’s diet. Only administer supplements in doses recommended by your veterinarian.
15. What foods contain Pterostilbene? Pterostilbene is found in blueberries, with the estimated content per blueberr y varying between 99 ng to 520 ng, depending on the type of blueberry. To put this into perspective, an average blueberry punnet weighs around 340 gra ms. If you ate the entire punnet, the total amount of pterostilbene you would ge t is only 0.03 to 0.18 mg, and based on the dose used in limited human stu dies of 100mg a day, that would be a huge amount of blueberries a day! However, if you are looking to naturally obtain the kind of levels of pterostilb ene that dietary supplements offer, then you would really, really, need to like blueberries, not to mention the high cost of buying that much fruit. In reali stic terms, this is impractical. Supplement dosages range from 50 mg to 1,00 0 mg per capsule. Pterostilbene is also found in almonds, grape leaves and vines, cranberries an d related Vaccinium berries, such as lingonberries, bilberries, and huckleberrie s.
16. What is Pterostilbene derived from? Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a stilbene compound th at is structurally similar to other popular stilbenes such as resveratrol or pice atannol; it is named after its first discovered source (the pterocarpus genus) but is also a component of blueberries and grape products. It is a phytoalexi n (compound produced by plants as a defense against parasites and insects) similar to resveratrol albeit more potent Pterostilbene sources include: Pterocarpus marsupium (Indian Kino Tree) and pterocarpus santalinus (Sandalw ood) Blueberries (92-550ng/g dry weight) Grape (Vitis vinifera) leaves and berries
Anogeissus acuminata The Dracaena genus Rheum rhaponticum (root) Peanuts (Arachis hypogaea)
17. Pterostilbene natural sources Pterostilbene is found in almonds, various Vaccinium berries (including blueber ries), grape leaves and vines, and Pterocarpus marsupium heartwood.
18. Is Pterostilbene a phytoestrogen The stilbenes family of phytoestrogens includes reseveratrol and pterostilbene which are commonly found in red wine and peanuts.
19. Is Pterostilbene fat soluble Yes, this is one of the difference between Pterostilbene and Resveratrol also. Without the methoxy groups Resveratrol is not as lipophilic (oil-soluble) as pt erostilbene, so it’s cellular uptake is much less than pterostilbene - pterostil bene can be taken through the cell’s lipid bi-layer rather easily.
20. Is Pterostilbene water soluble? Pterostilbene is practically insoluble (in water) and a very weakly acidic comp ound (based on its pKa). Pterostilbene can be found in common grape and g rape wine, which makes pterostilbene a potential biomarker for the consumpti on of these food products.
21. Does Pterostilbene increase LDL? Yes,Pterostilbene increases LDL when used in monotherapy. Pterostilbene reduc es blood pressure in adults at 250 mg/day doses. There appears to be poten tial for weight reduction in certain subgroups with pterostilbene.
22. Does Pterostilbene lowder blood pressure? A form of pterostilbene, a compound found naturally in blueberries, reduces blood pressure in adults, according to results of a clinical trial presented Sept. 20 at the American Heart Association's 2012 Scientific Sessions on High Bloo d Pressure Research in Washington, D.C. The randomized, double-blind, placebo-controlled study was conducted by Univ ersity of Mississippi School of Pharmacy and School of Medicine researchers t o determine whether pterostilbene (tero-STILL-bean), improves cardiovascular h ealth. Investigators evaluated the ingredient in 80 patients with high cholesterol (tot al cholesterol of 200 or greater and/or LDL cholesterol of 100 or greater). Tw ice daily for six to eight weeks, participants received either high (125 mg) do ses of pterostilbene, low (50 mg) doses of pterostilbene, pterostilbene (50 mg) with grape extract (100 mg), or a placebo, said Daniel M. Riche, the study's principal investigator. Investigators assessed patients' blood pressure, body we ight and blood lipids at the beginning and end of their participation in the st udy. "We found reduced systolic and diastolic blood pressure in patients who recei ved the high dose of pterostilbene and reduced systolic blood pressure in pat ients who received the low dose of pterostilbene with grape extract," said Ric he, an assistant professor of pharmacy practice and medicine at the UM Med ical Center in Jackson. Participants in the high-dose pterostilbene group (250 mg per day) achieved s ignificant reductions in blood pressure compared to placebo: 7.8 mmHg in sys
tolic BP (p less than 0.01) and 7.3 mmHg in diastolic BP (p less than 0.001).
23. Is Pterostilbene dangerous Pterostilbene is considered safe and has no significant side effects up to a do se of 250 mg per day. Some people may have increased LDL cholesterol whe n taking pterostilbene; grape seed extract negates this effect and may pair w ell with a pterostilbene supplement . There are currently no studies on the safety of pterostilbene for children or f or pregnant or breastfeeding women. Because this compound is commonly fo und in food and considered to be healthy, small doses of pterostilbene shoul d be safe for anyone; however, caution is advised at higher doses. Talk to your doctor before giving pterostilbene to children or taking it yoursel f if you are pregnant or breastfeeding.
24. How much Pterostilbene should I take? Pterostilbene is generally safe for use in humans at doses up to 250 mg per day. Pterostilbene is well-tolerated at a twice daily dosing frequency
25. Pterostilbene with or without food? According to the study which is the first well-designed comparison of pterostil bene in a dose-ranging controlled human trial. There appears to be no direct effect of pterostilbene on measures of hepatic or renal function. There is unlikely an association of pterostilbene with gastrointestinal ADR (wit h or without food) or itching as both reported ADRs occurred to a low exten t in only the placebo and high dose groups.
26. Should you take Pterostilbene? A human trial has shown that pterostilbene is safe up to a dose of 250 mg per day. Throw into the mix the fact that it’s commonly found in food, and it gets clear that pterostilbene is generally safe to use. Keep in mind, though, that this drug raises ‘bad’ cholesterol level in users.
27. What is the best time of day to take Pterostilbene? People may ask " When can I best take resveratrol, pterostilbene, curcumin a nd quercetin for optimal effect? " It is preferably consumed in the morning, or evening, but not during the day. Consume with water, with a small meal (breakfast).
28. What supplements contain Pterostilbene? As people pay more and more attention to health, people's demand for supp lements is also increasing day by day. Pterostilbene supplements are one of t hem, which is deeply loved by people. The main ingredient of Pterostilbene supplement of course is Pterostilbene po wder, it can used to make different kinds, include capsule,pills,drink... Pterostilbene as a methylated stilbene molecule, it has a similar structure to the antioxidant resveratrol. Pterostilbene and resveratrol share many of the sa me benefits, including fighting oxidative stress, but pterostilbene has been sho wn to have superior bioavailability. In other words, pterostilbene is believed t o be absorbed and utilized by the body more easily than similar phytonutrien ts, which is one reason why it’s recently caught the attention of health rese archers.
29. Is Pterostilbene better than Resveratrol? 1). What is Resveratrol Resveratrol is part of a group of compounds called polyphenols. They’re thou ght to act like antioxidants, protecting the body against damage that can put you at higher risk for things like cancer and heart disease. Resveratrol suppo rts cardiovascular health, antioxidant defenses, glucose metabolism, healthy infl ammatory balance, and more. Pterostilbene is now championed as a more po tent form with superior bioavailability. Resveratrol powder (501-36-0) base information Name
Resveratrol powder
CAS number
501-36-0
Purity
98%
Chemical name
Resveratrol
Synonyms
5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol; trans-R esveratrol; (E)-5-(p-Hydroxystyryl)resorcinol; (E)-Resveratrol; trans-3,4′,5-Trihydroxystilbene;
Molecular Formula
C14H12O3
Molecular Weight
228.24 g/mol
Melting Point
243-253°C
InChI Key
LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Form
White powder
Half Life
at studies, suggest a half life up to 1.6 hours
Storage Condition
protect from light, 2-8°C
Application
Minor constituent of wine, correlated with serum lipid re duction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.
Package picture
COA,HPLC
Available
2). Pterostilbene vs Resveratrol -A Comparison of Bioavailability and Health Benefits Nearly two decades ago, it was discovered that resveratrol slowed the proces s of cellular aging in yeast. In 2003, Harvard Medical School Professor David Sinclair, PhD, found that resveratrol activated a longevity gene called SIRT1 an d the resultant class of sirtuin proteins. Then, the same mechanism was studied and found to be true in mice. Invest igations into resveratrol then turned toward its effects on human health. Resv eratrol was found to support cardiovascular health, antioxidant defenses, gluco se metabolism, healthy inflammatory balance, and more. As results of these s tudies were reported, people became more interested in drinking resveratrol-ri ch red wine and taking resveratrol supplements.
However, some of the biggest hurdles for reaping the benefits of resveratrol i n humans appear to be its limited bioavailability and rapid elimination from t he body. But those hurdles might be overcome by a compound that has mor e recently gained some notice. About 10 years after the discovery that resveratrol activated a longevity gene, researchers began to take interest in its molecular cousin, pterostilbene. Alth ough it is present in a higher concentration in blueberries than in red wine, pterostilbene is nearly identical in chemical structure to resveratrol. The first human-safety study of pterostilbene was published in 2013, and inve stigations have intensified since then. Pterostilbene is now championed as a more potent form of resveratrol. It’s said to offer all of the previously known benefits of resveratrol but with superior bioavailability. Are these claims true? Read on for a detailed comparison of these two cousin compounds.
-Structural Differences Resveratrol and pterostilbene are both naturally occurring plant compounds. R esveratrol is concentrated in grape skins and red wine, but it has also been i solated from the roots of Japanese knotweed. Pterostilbene is concentrated pr imarily in blueberries, but it has also been found in small amounts in peanut s, grapes and cocoa. Resveratrol and pterostilbene fall into a class of compounds called stilbenes. T hese phenolic compounds consist of two aromatic rings with hydroxyl groups (-OH). Resveratrol and pterostilbene are very similar in structure, but with on e minute—yet critical—difference. Resveratrol has three hydroxyl groups, wher eas pterostilbene has only one. The other two hydroxyl groups are replaced b y methoxy groups (O-CH3) in pterostilbene. The difference in the number of hydroxyl groups is crucial because it influenc es how quickly the compound is metabolized and eliminated from the body. The three hydroxyl groups in resveratrol hasten the molecule’s removal, which makes it challenging to reach and maintain appreciable levels of resveratrol i n the bloodstream.
With only one hydroxyl group per molecule, pterostilbene is able to persist in circulation for a longer time. The slight difference in structure also makes pt erostilbene more lipophilic. Pterostilbene can more readily pass through cell membranes—making it more available to support cellular pathways. Both resveratrol and pterostilbene are naturally occurring in two forms: cis an d trans. The trans forms are more stable and more abundant in nature. Studi es suggest that for both resveratrol and pterostilbene, the trans forms are su perior to the cis forms in terms of biological activity.
-Bioavailability and Half-life The good news about resveratrol and pterostilbene is that they’re both readil y absorbed after oral intake, and are even capable of crossing the blood-brai n barrier. The bad news is that they’re rapidly metabolized. Their time in circ ulation is fleeting. The absorption rate of resveratrol from the intestinal lumen is about 75 perc ent, but its rapid metabolism in the liver results in oral bioavailability of only about 1 percent. That’s because the liver produces resveratrol conjugates—pr imarily glucuronides and sulfates. In a human bioavailability study, 15 healthy volunteers each took a 500 mg capsule of trans-resveratrol. Blood samples tak en after dosing showed that free resveratrol only represented 0.28 percent of total resveratrol in circulation, with the rest consisting of conjugated glucuro nides or sulfates. The study also showed that resveratrol was short-lived— its concentration pea ked at only about one hour after intake. That result was similar to an earlier study, which found that the half-life of trans-resveratrol was one to three ho urs following a single dose. When a compound has such low bioavailability and such a short half-life, it’s difficult to maintain a concentration in circulation. One study found that eve n when people took 150 mg of trans-resveratrol six times per day, they still had low plasma concentrations. One of the most commonly cited comparisons of resveratrol and pterostilbene
is that the oral bioavailability of resveratrol is only 20 percent, while pterosti lbene reaches 80 percent. But it’s important to note that these percentages r efer to the combined total of resveratrol plus resveratrol sulfate, and pterostil bene plus pterostilbene sulfate. It’s even more important to note that these percentages came from a study that was conducted in rats rather than huma ns. The other oft-cited comparison is that the half-life of pterostilbene is seven ti mes longer than that of resveratrol. This statistic comes from two studies: On e reported that resveratrol had a half-life of 14 minutes,and the other report ed that pterostilbene had a half-life of 105 minutes. Again, these were precli nical studies that were conducted not in humans but in rabbits, rats, and mic e. Several unanswered questions remain. We don’t know whether the conjugated metabolites of resveratrol and pterostilbene have biological activity at the tis sue level (there is some evidence of activity, albeit less than free resveratrol). Also, it’s unknown whether the bioavailability data on pterostilbene from ani mal studies can be translated to humans. Many researchers and clinicians are taking the limited data we have so far a bout the bioavailability of pterostilbene and running with it. Based on the stu dies mentioned above, pterostilbene has gained a reputation for being a mor e potent and bioavailable form of resveratrol.
-Comparison of Health Benefits Resveratrol has been extensively researched. Experimental studies show that r esveratrol modulates numerous molecular mechanisms at the cellular level. It interacts, for example, with cellular pathways related to healthy inflammatory balance, apoptosis, and autophagy. It also interacts with pathways associated with aging and longevity, such as telomeres and cell senescence. Despite its low bioavailability, there is abundant evidence for resveratrol’s abili ty to promote health in humans. Randomized, controlled trials have shown th at resveratrol supplementation supports healthy weight management, blood-sug ar metabolism, cardiovascular function, mood, healthy inflammatory balance a
nd oxidative stress. Resveratrol’s health benefits have also been shown in ma ny other studies, and even meta-analyses. When it comes to pterostilbene, the evidence is much sparser. Aside from a safety study published in 2013, there have been very few trials conducted in humans. There was one study, conducted at the University of Mississippi in 8 0 adults, which found that pterostilbene supported healthy blood pressure an d lipid metabolism. The vast majority of research on pterostilbene is in the experimental and pre clinical phase. Researchers have found that pterostilbene supports many of th e same cellular pathways as resveratrol—including supporting antioxidant defe nses and modulating pathways involved in healthy inflammatory balance, apop tosis, and autophagy. Most experts agree that the molecular mechanisms of p terostilbene should be considered equivalent to those of resveratrol.
30. Who should not take resveratrol Patients who have blood disorders, which can cause bleeding, should be moni tored by a physician while taking this product. People undergoing surgery sho uld stop taking resveratrol two weeks before the surgery and not take it for two weeks after the surgery to reduce the risk of bleeding. Do not take resveratrol supplements or excessive amounts of natural foods co ntaining resveratrol while pregnant or breast-feeding. There is a lack of resear ch in this area to prove safety. Resveratrol should be avoided in children. Resveratrol has mild estrogenic activity and until more is known, women with cancers and other conditions that are estrogen sensitive should seek medical advice before taking resveratrol. Resveratrol reduces the activity of enzymes involved with drug metabolism bu t whether it has a significant effect in humans has not been studied.
31. How much resveratrol is safe? Resveratrol supplements are possibly safe when taken by mouth in doses up to 1500 mg daily for up to 3 months. Higher doses of up to 2000-3000 mg daily have been used safely for 2-6 months. But these higher doses are more likely to cause stomach upset.
32. Pterostilbene with caffeine Caffeine is a methylxanthine found in coffee beans, cocoa beans and in tea. Research shows that caffeine is a brain stimulant that increases alertness, wak efulness, attention, working memory, and motor activity. There is product which is a patented compound binding caffeine with the pot ent antioxidant pterostilbene. Binding caffeine with pterostilbene significantly sl ows the absorption rate of caffeine lengthening its half life and delivering up to 30% more total effect while reducing typical caffeine crash symptoms.
33. Pterostilbene with quercetin 1) What is quercetin and its benefits Quercetin is a plant pigment (flavonoid). It's found in many plants and foods, such as red wine, onions, green tea, apples, and berries. Quercetin has antioxidant and anti-inflammatory effects that might help reduc e swelling, kill cancer cells, control blood sugar, and help prevent heart disea se. Quercetin is most commonly used for conditions of the heart and blood vess els and to prevent cancer. It is also used for arthritis, bladder infections, and diabetes, but there is no strong scientific evidence to support most of these uses. There is also no good evidence to support using quercetin for COVID-1
9.
2) Pterostilbene vs Quercetin There is a special class of antioxidant compounds call flavonoids or polypheno ls, so eating a diet rich in fruits and especially vegetables can go a long way toward keeping you healthy. Quercetin and pterostilbene are two such flavonoids. However, because these antioxidants are found in very small amounts in only a handful of foods and your body's ability to absorb them in their natural state is poor or inadequat e, your potential for benefits is limited. With Quercetin and Pterostilbene advanced formula, use professional teachnol ogy to increase these compunds' bioavailability by as much as 20 times. Wit h special formula, you may get: 1) Supports your natural defense against seasonal threats. 2) Supports lung and bronchial tract health. 3) Supports the production of new mitochondria in your brain and muscle. 4) Supports a healthy, normal immune response. 5) Helps protect cells and tissues against free radical damage. 6) Supports an already normal inflammatory response. 7) Boosts mental performance following extreme physical stress. 8) Supports healthy cellular aging. 9) Helps protect against lipid peroxidation in your cells and tissues. 10) Supports metabolic health.
34. Pterostilbene vs berberine Berberine is a bioactive compound that can be extracted from several differe nt plants, including a group of shrubs called Berberis. HCL is the hydrochlorid e form of Berberine, CAS number is 633-65-8. Technically, it belongs to a class of compounds called alkaloids. It has a yello
w color, and has often been used as a dye. Berberine has a long history of use in traditional Chinese medicine, where it was used to treat various ailments. Now, modern science has confirmed that it has impressive benefits for several different health problems. Pterostilbene is a substance found in very small quantities in blueberries. In l arger quantities, it can improve insulin sensitivity (R,R,R), and could improve t ype 2 diabetes (R,R). Just like metformin, pterostilbene can also activate AMPK (R). In fact, pterostil bene activated AMPK already at levels of 50 micromolar, while metformin ach ieved the effect at a higher dose of 2 millimolar (R).
35. Pterostilbene and NMN 1) What is NMN NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. At the molecular level, it is a ribo-nucleotide, which is a basic structural unit of the nucleic acid RNA. Structurally, the molecule is composed of a nicotinamide group, a ribose and a phosphate group. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells. NMN powder (1094-61-7) base information Name
NMN powder
CAS number
1094-61-7
Purity
99%
Chemical name
beta-Nicotinamide mononucleotide
Synonyms
3-Carbamoyl-1-[5-O-(hydroxyphosphinato)-β-D-ribofuranosyl] pyridinium
Molecular Formula
C11H15N2O8P
Molecular Weight
334.221 g/mol
Melting Point
>96°C
InChI Key
DAYLJWODMCOQEW-TURQNECASA-N
Form
White powder
Half Life
/
Storage Condition
Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Application
Nicotinamide mononucleotide (“NMN”, “NAMN”, and “β-N MN”) is a nucleotide derived from ribose and nicotinami de.
COA,HPLC
Available
NMN powder
2) Pterostilbene with NMN Combining pterostilbene and NMN (nicotinamide mononucleotide) may be a p owerful duo for slowing down the aging process. NMN is a precursor to NAD +, a crucial coenzyme needed by every cell in the body. A decrease in NAD+ levels leads to an increase in the progression of aging and disease. Both pterostilbene and NMN are activators of sirtuins, a family of proteins th at regulate cellular and mitochondrial health and control the aging process. In creased sirtuin activity, especially SIRT1, has been linked to increased lifespan in yeast and animals. Due to its superior bioavailability, pterostilbene may be a stronger sirtuin activator than resveratrol. Combining pterostilbene and NMN may increase NMN’s effectiveness because sirtuin activators and NAD+ boosters work together. As pterostilbene increase s sirtuin activity, adding NMN allows for the precursor molecule to do its pri mary job of boosting NAD+ levels.
Essentially, NMN and pterostilbene work synergistically to improve mitochondri al health and slow down the aging process, as NMN boosts NAD+ levels and both compounds activate sirtuins.
36. Pterostilbene and Nicotinamide riboside 1) What is Nicotinamide riboside(NR) Nicotinamide riboside is a member of the vitamin B3 family, which also includes niacin and niacinamide. It's found in fruits, vegetables, meat, and milk. Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels. People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses. Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.
2) Pterostilbene with Nicotinamide riboside(NR) Some dietary supplements contain Pterostilbene and Nicotinamide Riboside(NR). Nicotinamide riboside is a precursor to nicotinamide adenine dinucleotide(NA D+). If you’re taking Pterostilbene with Nicotinamide Riboside ”NR” (Reviews), you might want to reconsider. NR expert Dr. Charles Brenner explained on T witter earlier.
37. Where to buy Pterostilbene? Wisepowder as direct manufacturer, provide the best quality Pterostilbene po wder from gram-KG-Ton to support different clients’ need.
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