What are the benefits of Fisetin? Fisetin benefits are quite a few, and they have all been seen on animal models. No research has been able to conclusively determine these benefits in humans as most studies are still in the clinical phase. The different benefits of fisetin include:
Anti-Aging Aging of the body is marked by a net increase in senescent cells, that are no longer able to divide. These cells release inflammatory signals, which results in the complications of aging most commonly seen. Most age-related disorders are due to abhorrent inflammation in the body promoted by the senescent cells. Fisetin powder consumption targets these cells and removes them from the body, hence, reducing inflammation and slowing down the aging process. Diabetes management In animal models, fisetin supplement has been shown to reduce blood sugar levels significantly. This effect of fisetin comes from the flavonoid’s ability to increase insulin levels, increase glycogen synthesis, and decrease the liver’s ability to initiate gluconeogenesis. Basically, fisetin acts on every pathway in the body that results in glucose production and stops those while activating the pathways that either store or use up the glucose in the bloodstream. Anti-Cancer The anti-cancer effects of fisetin powder differ based on the type of cancer. In a study performed on prostate cancer, fisetin was able to reduce the growth of cancer by blocking testosterone and DHT receptors, which are important for the growth of prostate cancer. In another study where the cancer being studied was lung cancer, fisetin supplements were able to increase antioxidants in the blood that had been reduced by tobacco use. Fisetin was also able to reduce the growth of lung cancer by 67 percent on its own, and 92 percent when combined with a chemotherapy drug. When used in colon cancer, fisetin significantly
reduced the inflammation associated with colon cancer. The study, however, did not mention any effect of fisetin on cancer growth. Neuroprotective When older rats with age-related decline in cognition were given fisetin supplement, there was a significant improvement in their cognitive skills and memory. In another study, animal models were exposed to neurotoxic substances and then given a fisetin supplement. The test subjects were found to have not experienced any memory loss due to the supplement. However, it is not known if fisetin can cross the human blood-brain barrier with the same efficiency as the mice blood-brain barrier. Fisetin is also neuroprotective in the sense that it prevents the development of neurodegenerative disorders such as Alzheimer’s by reducing the accumulation of harmful proteins in the brain. Similarly, mice with ALS showed an improvement in their balance and muscle coordination after being given fisetin powder. They also experienced a prolonged life span than what was expected. Cardioprotective Researchers studied the effect of fisetin powder on the cholesterol levels of rats who were fed a high-fat diet. Total cholesterol and LDL levels were found to have decreased significantly whereas HDL levels almost doubled. The hypothesized mechanism through which fisetin rids the body of cholesterol is believed to be increased release of it into bile. The reduced cholesterol, overall, has a cardioprotective effect. All these fisetin benefits point toward anti-aging and longevity of life which should be enough to promote more clinical studies so that the compound can be approved for medicinal use.