FISETIN: WHY ARE PEOPLE TAKING THIS SUPPLEMENT?

FISETIN: WHY ARE PEOPLE TAKING THIS SUPPLEMENT? Fisetin is a flavonoid found in many fruits and vegetables. It has been shown to have anti-inflammatory, antioxidant, and anticancer effects. Because of the potential healt h benefits it may provide, fisetin supplements are becoming more popular as people look for alternatives to other medications that they may not be comfortable with or want to take long term. In this blog post we will explore what fisetin is, why people a re taking it, potential benefits and discuss current research being done around Fisetin and how this could impact future treatments available for those looking to improve t heir health naturally.

Origins & History of Fisetin Fisetin is a naturally occurring flavonoid compound. Flavanoids are water-soluble co mpounds found in plants and have antioxidant properties. Water-soluble means that Fisetin can dissolve in water. Fisetin is not found to be fat-soluble, which means it can not dissolve into fats or lipids that are normally soluble in oils. Fisetin was isolated fro m the Fruiting bodies of a Fungus called Fomes Fomentarius. The Fruiting body of thi s fungus is responsible for producing all of the spores that are used to reproduce. Fis etin can also be found in many plants including Ginko Biloba, strawberries, persimmo ns. Fisetin’s chemical structure was first identified chemical formula was first describ ed by Austrian chemist Josef Herzig in 1891. Fisetin can be found throughout the pla nt kingdom, where it acts as a photosynthesis inhibitor and UV protectant. Fisetin ha s even been isolated from insects, including ants, aphids, and wasps.

Fisetin is also said to be one of the many flavonoids that are found abundantly in the plant subfamily Cornoideae, which includes Foeniculum vulgare, Foeniculum dulce, a nd Coriandrum sativum. Fisetin was first isolated from Foeniculum vulgare, Fennel. Fi setin was first isolated from the bark of the Pacific wax myrtle tree and has since bee n found in many fruits and vegetables. Fruits and vegetables that are high in fisetin in clude:

– Strawberries; specifically, they are Fisetin’s highest food source.

– Red grapes – Apples – Asian pear – Fennel seeds (Foeniculum vulgare) Fisetin is a member of the flavonoids, which are plant pigments produced by many plants to help protect themselves from outside str essors, such as ultraviolet light, insects, and herbivores.

Why are people taking Fisetin?

Natural supplements are becoming increasingly popular in the health and wellness c ommunity. There are a number of different types of natural supplements such as pro biotics, prebiotics, digestive enzymes, amino acids and herbal extracts that all serve t heir own specific purposes. There are many reasons why people take natural supple ments. Some people want to support their bodies’ natural processes, others want na tural help with a specific health concern, and some just want to maintain good health.

Dietary supplements have been one way that consumers have sought to fulfill unmet dietary needs. Fisetin is one of many supplements like this that people are turning to attempt to make themselves feel better. Many of my patients opt to take supplemen ts to make sure they get enough essential nutrients and to maintain or improve their health.

POTENTIAL BENEFITS Fisetin is a naturally occurring antioxidant found in many fruits and vegetables. Fiseti n is known as a neuroprotective agent, meaning it has been shown to have potential benefits in helping the body fight against both acute and chronic neurological disease s. Fisetin is one of the most common and bioactive flavonoids which possesses pote ntial neuroprotective effects. Fisetin also enhances learning and memory, decreases neuronal cell death, and suppresses oxidative stress. Fisetin has been shown to have significant protective effects on the body from oxidative stress, which is why Fisetin may be taking it as it can potentially be beneficial for those looking to improve their health or prevent disease. Oxidative stress refers to the level of damage done to cells in the body by free radicals. Fisetin has been shown to have some effect against oxid ative stress, but it is not yet known whether Fisetin itself can actually reduce oxidativ e stress or if Fisetin can enhance antioxidants that are already present in the body. It i s also unknown how Fisetin works as an antioxidant. Fisetin may work as a scavenger, Fisetin can bind to free radicals, Fisetin could be regenerating the antioxidants that it is acting with, or Fisetin itself may act as an antioxidant. There is still much to learn a bout Fisetin.

FISETIN AND LONGEVITY As we age, we accumulate damaged cells. Damaged cells can cause tissues to functio

n improperly or not work at all. Fisetin has been shown to reduce senescent cell burd en in mice by activating the body’s enzymes that clear out senescent cells. Senescent cells are cells that have stopped dividing to replicate themselves. Senescent cells can accumulate in all tissues with age and secrete pro-inflammatory cytokines and chem okines. Fisetin has been shown to increase the lifespan of mice. In a recent study, Ad ministration of fisetin to wild-type mice late in life restored tissue homeostasis, reduc ed age-related pathology, and extended median and maximum lifespan.

FISETIN & and mTOR mTOR is responsible for controlling cell growth, division, and metabolism. Recent res earch shows how Fisetin inhibits the mTOR pathway. When you inhibit the mTOR pat hway you are essentially slowing down the aging process.

Fisetin & Inflammaging Inflammaging refers to the chronic low-grade inflammation that is caused by cellular damage, oxidative stress, and mitochondrial dysfunction. Fisetin is believed to be abl e to reduce inflammation because Fisetin has shown an ability to reduce cellular (nuc lear) damage in animal studies. This is accomplished by Fisetin’s ability to inhibit by in hibiting pro-inflammatory enzymes and substances, like lipoxygenases and NF-kB.

FUTURE RESEARCH As research continues on this compound more information about how fisetin could b e used for medicinal purposes will be revealed. Fisetin holds great potential for multi ple applications in medicine, and research studies have shown Fisetin’s positive anti-i nflammatory and anticancer effects on different cell types. Over the last two decades, much attention has been drawn to plant-derived bioactive compounds as novel ther apeutic agents for treatment of neurodegenerative diseases such as Alzheimer’s dise ase (AD) and Parkinson’s disease (PD). The current research suggests that the benefit s of Fisetin may be worth considering for those looking for natural options to improv e their health.