in COPD patients

Oxidative stress induced by smoking and air pollution in COPD patients

Ioana Buculei

Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Doctoral school of the Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iasi

Mona Elisabeta Dobrin

Medical Science Department, University of Medicine and Pharmacy „Iuliu Hațieganu” Cluj-Napoca, Clinical Hospital of Pulmonary Diseases Iasi

Daniela Matei

Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi

Ilie Onu

Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Doctoral school of the Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, Technical University “Gheorghe Asachi” Iasi

Cristina Vicol

Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Doctoral school of the Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iasi

Ionel Bogdan Cioroiu

Romanian Academy, Iași Branch, Research Center for Oenology, Iasi

Marius Niculaua

Romanian Academy, Iași Branch, Research Center for Oenology, Iasi

Daniel Andrei Iordan

Department of Individual Sports and Kinetotherapy, Faculty of Physical Education and Sport, “Dunărea de Jos” University of Galati

Antigona Carmen Trofor

Clinical Hospital of Pulmonary Diseases Iasi, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iasi

Keywords: COPD, oxidative stress, air pollution, smoking, uric acid

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Lungs is a target organ for exposure to cigarette smoke and air pollution, and the role of the two risk factors in the development and evolution of COPD is well known. Smoking and air pollutants can have synergistic effects on each other, but also on genetic factors or respiratory infections, which leads to increased incidence and severity of chronic obstructive pulmonary disease. Oxidative stress, through its biological effects and the tissue damage it causes, is involved in the development of respiratory diseases, implicitly COPD. Cigarette smoke and air pollutants can directly generate oxidants and also reduce the production of antioxidants both at the respiratory and the systemic level. The aim of this study was to correlate tobacco use and exposure to air pollution with oxidative stress markers useful in clinical practice in patients with COPD. A study assessing uric acid as an antioxidant response marker, smoking profile quantified by the number of packs-years (PY) and polycyclic aromatic hydrocarbons (PAHs) serum levels as markers of exposure to air pollution was conducted on 102 patients divided into two groups. Monitoring biomarkers of oxidative stress in this category of patients may improve disease management.

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