HPV Knowledge and Vaccination Rates in an Urban Obstetrics and Gynecology Clinic Population Madeleine Burlingame, B.A.,1 Cameron Tate, B.A.,1 Gary L. Goldberg, M.D.,1,2 Celeste Azevedo, M.D.1,3 1. Zucker School of Medicine, Northwell Health, 2. Feinstein Institute of Medical Research, 3. Long Island Jewish Medical Center, Department of Obstetrics and Gynecology
Background Human papillomavirus (HPV) is known to be associated with genital warts and malignancy, including oropharyngeal and anogenital cancers. Inoculation with the HPV vaccine has been shown to reduce the incidence of these complications. Recent studies have estimated vaccination of cisgender women and men ages 19-26 to be far lower than the 80% coverage goal of Healthy People 2030 for the general population.
Figure 1. Percent Vaccinated between Ages
19-261
The FDA has approved the HPV vaccine for all genders up to the age of 45. With the FDA’s approval, there is now a significantly larger patient population eligible to receive the vaccine and thus, an opportunity for providers to provide education and increase the rate of HPV vaccination. There is little existing data on vaccination rates in older age groups. By administering surveys to patients in a general obstetrics and gynecology clinic population, we hope to determine an institution specific rate of HPV vaccination and to develop interventions to increase the current rate of vaccination among patients and their children.
Figure 2. Cancers Attributable to HPV Infection1
Hypothesis - Investigators hypothesized that clinic populations will have low baseline knowledge about HPV and the HPV vaccine - Investigators hypothesized that clinic populations will have low HPV vaccination rates and bias against HPV vaccines - Investigators hypothesized that current counseling about HPV vaccination from providers is inadequate - Finally, investigators hypothesized that children, especially male children, of participants are likely under-vaccinated
Methods Aims: - To determine the HPV vaccination rate in the general Obstetrics & Gynecology clinic at LIJ Medical Center - To understand the clinic population's prior knowledge of and barriers to HPV vaccination - To design educational interventions to increase HPV vaccination rates Inclusion Criteria: - 300 patients had previously been enrolled in this study - From June 2021 to August 2021, we enrolled 300 additional patients - Inclusion: Patients between the ages of 18-45 years old were approached during visits to the obstetrician/gynecologist - Exclusion: age <18 years or >45 years, current pregnancy Survey Instrument: - A survey was created to assess patient demographics, methods of contraception, history of STIs and abnormal pap smear, baseline knowledge about vaccination, vaccination status of children, and intent to vaccinate future children - When patients indicated that they had refused the HPV vaccine, the instrument assessed the motivation behind their refusal
Results/Conclusions Dataset: - Between June 2021 and August 2021, we enrolled 300 patients in the study - Survey responses were entered into REDCap Statistical Analysis: - Statistical analysis will be completed once study enrollment is complete - Analysis will focus demographic information (age, race/ethnicity, religion), medical history (history of STIs, abnormal pap smear), knowledge of HPV vaccine, receipt of the vaccine, and intent to vaccinate current or future children - Analysis will include reasons for vaccine refusal and consider how educational incentives may assist in increasing vaccination rates
Future Direction This study is ongoing. Once all participants has been recruited, data will be analyzed using descriptive statistics. Statistical analysis will be conducted using SPSS. With the study results, educational initiatives will be designed to increase the rate of HPV vaccination.
Resources Figure 7: Independent CRISPR knockout of CDK4 or CDK6 does not cause dropout in most breast cancer cell lines studied.
1. Griffin, M., Jaiswal, J. & Stults, C.B. Human Papillomavirus Vaccination Rates by Gender Identity and Sexual Orientation Among 18–44-Year-Olds in the U.S.. Arch Sex Behav (2021). 2. Perkins RB, Apte G, Marquez C, Porter C, Belizaire M, Clark JA, Pierre-Joseph N. Factors affecting human papillomavirus vaccine use among White, Black and Latino parents of sons. Pediatr Infect Dis J. 3. Holman DM, Benard V, Roland KB, Watson M, Liddon N, Stokley S. Barriers to human papillomavirus vaccination among US adolescents: a systematic review of the literature. JAMA Pediatr. 2014 4. Clark SJ, Cowan AE, Filipp SL, Fisher AM, Stokley S. Parent Perception of Provider Interactions Influences HPV Vaccination Status of Adolescent Females. Clin Pediatr (Phila).