BENEXIA Xia Oil Science-Based Applications

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XIA OIL

Science-Based Application Concepts

BONE HEALTH

MENOPAUSE & POST MENOPAUSE SUPPORT

MALE FERTILITY

SPORTS NUTRITION & RECOVERY

COGNITION & NEUROLOGICAL SUPPORT FOR ELDERLY

GUT HEALTH & IBS SUPPORT

DIETARY SUPPLEMENTS

Application Concept in Dietary Supplements/Functional Foods

BONE HEALTH FOR POSTMENOPAUSAL WOMEN

CALCIUM + VITAMIN D + CHIA OIL ALA POWDER

Calcium and vitamin D are essential for healthy bones. Combining these key nutrients with the highest plant-based source of alpha-linolenic acid (ALA) may support strong bones and reduce joint inflammation as women age.

RECOMMENDED FOR

Women 50 and older

1 in 4 postmenopausal women in both Europe and the U.S. have osteoporosis

1 in 3 women will have an osteoporotic fracture in their lifetime

Fragility-related fractures may increase by 25% by 2034

INGREDIENTS

Benexia ALA Powder 40 (microencapsulated chia oil [70%], acacia gum [30%]), Calcium carbonate, vitamin D, natural flavor and color.

COMPOSITION/NUTRITION FACTS

RECOMMENDED INTAKE

One 15-g scoop per day

SUGGESTED FORMAT

450g (15.9 oz) jar (30 dosages)

NUTRIENT CONTENT CLAIMS*

• Excellent source of omega-3s | USA

• High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS*

Alpha-Linolenic Acid and Calcium | USA

• Minimizes bone loss

• Supports joint health

• Reduces inflammation

Alpha-Linolenic Acid | EU ALA contributes to the maintenance of normal blood cholesterol levels.

Calcium | EU

Calcium helps reduce bone mineral loss in postmenopausal women

KEY ADVANTAGES

• Sustainable

• Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Pairing omega-3s with calcium and vitamin D can offer additional bone and joint protection for women ages 50 and older. The benefits from ALA omega-3s may be greater than other forms of omega-3 supplementation such as DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid).

THE EVIDENCE: OMEGA-3S

May enhance calcium absorption

Omega-3 fatty acids may alter the lipid composition of cell membranes, helping cells take in more calcium that can then be put towards building and maintaining bone tissue. These alterations may also reduce rates of calcium loss.

May reduce inflammation to reduce bone loss and enhance bone growth

Rates of low-grade inflammation naturally increase with age. Omega-3s offer protection by turning down the production of pro-inflammatory cytokines that may stimulate the breakdown, or resorption, or bone tissue. Simultaneously, these anti-inflammatory properties may also stimulate the formation of healthy new bone tissue.

ALA omega-3 may be particularly effective at these tasks. Compared to supplementing with DHA and EPA, ALA supplementation is tied to:

• Significantly higher levels of Bone-specific alkaline phosphatase (BALP), a bone enzyme involved in generating new bone tissue.

• Lower levels of markers of bone resorption, such as C-terminal telopeptide of type 1 collagen (CTX) and N-terminal telopeptide (NTx).

May enhance physical function

Greater physical activity supports stronger, healthier bones. Among postmenopausal women, dietary intake of ALA omega-3 has been shown to positively impact key parameters of physical function in just three days, including faster walking speed, greater grip strength, lower fat mass, better balance, and increased squatting ability.

BONE METABOLISM

The continuous process of forming new bone tissue and breaking down, or resorbing, old or damaged bone tissue to help bones maintain their structural integrity.

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, we know that women's bodies are more efficient than men, with a conversion rate of 21% for EPA and 9% for DHA.

More significantly, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.

References

1. Office of the Commissioner. (2024, May 13). Osteoporosis. U.S. Food And Drug Administration. https://www.fda.gov/consumers/womens-health-topics/ osteoporosis.

2. Cooper, C., Halbout, P., Reginster, J.-Y., & Kanis, J. A. (2021). SCORECARD FOR OSTEOPOROSIS IN EUROPE. In SCOPE 2021 Summary Report. https://www. osteoporosis.foundation/sites/iofbonehealth/files/2022-01/SCOPE%20 Summary%20Report.pdf

3. Liu Z, Cai S, Chen Y, Peng Z, Jian H, Zhang Z, Huang H. The association between dietary omega-3 intake and osteoporosis: a NHANES cross-sectional study. Front Nutr. 2025 Jan 10;11:1467559. doi: 10.3389/fnut.2024.1467559. PMID: 39867554; PMCID: PMC11757016.

4. Dou Y, Wang Y, Chen Z, Yu X, Ma D. Effect of n-3 polyunsaturated fatty acid on bone health: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr. 2021 Nov 29;10(1):145-154. doi: 10.1002/fsn3.2655. PMID: 35035917; PMCID: PMC8751426.

5. Troy KL, Mancuso ME, Butler TA, Johnson JE. Exercise Early and Often: Effects of Physical Activity and Exercise on Women's Bone Health. Int J Environ Res Public Health. 2018 Apr 28;15(5):878. doi: 10.3390/ijerph15050878. PMID: 29710770; PMCID: PMC5981917.

6. Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct Target Ther. 2023 Jun 8;8(1):239. doi: 10.1038/s41392-023-01502-8. PMID: 37291105; PMCID: PMC10248351.

7. Isanejad, M., Tajik, B., McArdle, A. et al. Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65–72 years. Eur J Nutr 61, 1813–1821 (2022). https://doi.org/10.1007/s00394-021-02773-Z.

8. Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

9. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

10. Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016. Epub 2015 Dec 12. PMID: 27012633.

Application Concept in Dietary Supplements/Functional Foods

FUNCTIONAL COLLAGEN PEPTIDES POWDER FOR POST-MENOPAUSAL WOMEN

EASY-MIX CHIA OIL + COLLAGEN PEPTIDES POWDER

Alpha-linolenic acid (ALA), highly hydrolyzed bovine collagen peptides, and calcium combine synergistically to offer joint protection and bone and anti-inflammatory support in a highly bioavailable, easy-to-mix drink powder.

RECOMMENDED FOR

Women ages 50+

In the U.S., 6,000 women enter menopause each day.1

Musculoskeletal pain increases with age and may be tied to the onset of menopause. 2

INGREDIENTS

Hydrolyzed bovine collagen peptides, Benexia® ALA Powder 40 [chia oil (70%), acacia gum (30%)], calcium carbonate].

COMPOSITION/NUTRITION FACTS

• 1,400 mg ALA omega-3s

• 10 g hydrolyzed bovine collagen peptides

• 400 mg calcium (31% VRN)

1400 mg Omega-3 ALA to Boost Physical Function Reduce Low-Grade Inflammation

RECOMMENDED INTAKE

One scoop (15 grams) daily for at least 3 months

SUGGESTED FORMAT

450g (15.9 oz. 0.99lb) jar (30 dosages)

NUTRIENT CONTENT CLAIMS*

Excellent Source of Omega-3 | USA

High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS:

Alpha-linolenic acid | USA

ALA omega-3s promote cardiovascular health

Alpha-linolenic acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels

Calcium | EU

Calcium helps reduce the loss of bone mineral in postmenopausal women FUNCTIONAL FOOD

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Declines in the hormone estrogen can lead to or worsen joint pain during and after menopause. Dietary ALA omega-3s may improve joint health and physical capacity in older women, making them an effective way to delay and/ or prevent declines in function.

THE EVIDENCE: ALA AND ENHANCED PHYSICAL FUNCTION

• Women with higher dietary ALA intake show enhanced physical function parameters including faster walking speed, greater grip strength, lower fat mass, and better balance and squatting ability. 3

• Supplementing with omega-3 fatty acids has consistently been shown to relieve joint pain while improving function. 4

THE EVIDENCE: ALA REDUCES LOW-GRADE INFLAMMATION

ALA reduces levels of low-grade inflammation that naturally increase with aging and contribute to musculoskeletal joint pain and functional declines. 5

THE EVIDENCE: OMEGA-3S SUPPORTS MUSCLE HEALTH

Omega-3s contributes to muscle protein synthesis. This can help prevent age-related muscle loss that can lead to frailness.6

THE EVIDENCE: OMEGA-3S AND HEART HEALTH

Estrogen exerts a protective effect on the heart, where declining levels can increase a woman's risk for heart disease, heart attack, and stroke.7 Supplemental omega-3 can play a key role in combatting these problems by aiding in BMI and waist circumference reduction and lower blood pressure and triglycerides. 8

THE EVIDENCE: ALA VS. DHA

When it comes to getting our omega-3 needs met, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.9,10,11

References

1. Cho L, Kaunitz AM, Faubion SS, Hayes SN, Lau ES, Pristera N, Scott N, Shifren JL, Shufelt CL, Stuenkel CA, Lindley KJ; ACC CVD in Women Committee. Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long? Circulation. 2023 Feb 14;147(7):597-610. doi: 10.1161/ CIRCULATIONAHA.122.061559. Epub 2023 Feb 13. PMID: 36780393; PMCID: PMC10708894.

2. Watt FE. Musculoskeletal pain and menopause. Post Reproductive Health. 2018;24(1):34-43.

3. Isanejad M, Tajik B, McArdle A, Tuppurainen M, Sirola J, Kröger H, Rikkonen T, Erkkilä A. Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65-72 years. Eur J Nutr. 2022 Jun;61(4):1813-1821. doi: 10.1007/s00394-021-02773-z. Epub 2021 Dec 16. PMID: 34913105; PMCID: PMC9106622.

4. Deng W, Yi Z, Yin E, Lu R, You H, Yuan X. Effect of omega-3 polyunsaturated fatty acids supplementation for patients with osteoarthritis: a meta-analysis. J Orthop Surg Res. 2023 May 24;18(1):381. doi: 10.1186/s13018-023-03855-w. PMID: 37226250; PMCID: PMC10210278.

5. Isanejad M, Tajik B, McArdle A, Tuppurainen M, Sirola J, Kröger H, Rikkonen T, Erkkilä A. Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65-72 years. Eur J Nutr. 2022 Jun;61(4):1813-1821. doi: 10.1007/s00394-021-02773-z. Epub 2021 Dec 16. PMID: 34913105; PMCID: PMC9106622.

6. Isanejad M, Tajik B, McArdle A, Tuppurainen M, Sirola J, Kröger H, Rikkonen T, Erkkilä A. Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65-72 years. Eur J Nutr. 2022 Jun;61(4):1813-1821. doi: 10.1007/s00394-021-02773-z. Epub 2021 Dec 16. PMID: 34913105; PMCID: PMC9106622.

7. El Khoudary SR, Aggarwal B, Beckie TM, Hodis HN, Johnson AE, Langer RD, Limacher MC, Manson JE, Stefanick ML, Allison MA; American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention; and Council on Cardiovascular and Stroke Nursing. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association. Circulation. 2020 Dec 22;142(25):e506-e532. doi: 10.1161/ CIR.0000000000000912. Epub 2020 Nov 30. PMID: 33251828.

8. Khan SU, Lone AN, Khan MS, Virani SS, Blumenthal RS, Nasir K, Miller M, Michos ED, Ballantyne CM, Boden WE, Bhatt DL. Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis. EClinicalMedicine. 2021 Jul 8;38:100997. doi: 10.1016/j.eclinm.2021.100997. PMID: 34505026; PMCID: PMC8413259.

9. Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

10. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

11. Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016. Epub 2015 Dec 12. PMID: 27012633.

DIETARY SUPPLEMENTS

Application Concept in Dietary Supplements/Functional Foods

OMEGA-3 BOOSTER FOR MENOPAUSE SUPPORT

CHIA + ALGAE OIL NUTRITIONAL DROPS

Shifts in the hormone estrogen can cause unpleasant symptoms during the menopausal transition. ALA and DHA omega-3 fatty acids can help manage these symptoms and support overall health.

RECOMMENDED FOR

Women ages 40 and older for perimenopausal and postmenopausal support.

In the U.S., 6,000 women enter menopause each day 1

INGREDIENTS

Chia seed oil, algae oil.

COMPOSITION/NUTRITION FACTS

2,492 mg

258 mg

RECOMMENDED INTAKE

One tsp (5 mL) up to twice per day.

SUGGESTED FORMAT

130 mL (4.3 oz) bottle (26 dosages).

NUTRIENT CONTENT CLAIMS*

Excellent Source of Omega-3 | USA

High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS*

Alpha-Linolenic Acid | USA

ALA may support the immune system

Alpha-Linolenic Acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels

KEY ADVANTAGES

• Sustainable

• Plant-based source of omega-3s

Up to 80% of women experience menopause symptoms that adversely impact their quality of life and productivity2

Up to 80% of women are short on important nutrients such as omega-3 fatty acids 3

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Alpha-Linoleic Acid (ALA)
Docosahexaenoic Acid (DHA)

The Science

IN SUMMARY: Women become less effective at converting ALA omega-3s to DHA omega-3s during the menopausal transition. Supplementing with ALA and DHA omega-3s can support this reduced capacity, and in turn, help manage menopause-related symptoms.

THE EVIDENCE: WOMEN AND OMEGA-3 CONVERSION

Research shows that younger women convert alphalinolenic acid (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) much more efficiently than men, in large part thanks to estrogen. As estrogen levels decline during menopause, the synthesis of ALA to DHA becomes downregulated, making omega-3 supplementation essential. 4,5,6

THE EVIDENCE: OMEGA-3S IN MENOPAUSE

The menopausal transition is associated with an increased risk for a range of symptoms and conditions. Many of those issues can be better managed with the help of supplemental omega-3 fatty acids, including:

• Heart Health. Estrogen exerts a protective effect on the heart, where declining levels can increase a woman's risk for heart disease, heart attack, and stroke[7]. Supplemental omega-3 can play a key role in combatting these problems by aiding in BMI and waist circumference reduction and lower blood pressure and triglycerides[8].

• Mood and Brain Fog. The risk for mood disorders and cognitive impairment increases in menopause. Research suggests that supplementing with omega-3s can improve depressive symptoms while enhancing critical aspects of cognition related to motivation, such as energy and alertness[9].

• Joint Pain. Thanks to hormone shifts and the natural effects of aging, more than half of women experience joint pain during and after menopause. Supplementing with omega-3 fatty acids has consistently been shown to relieve joint pain while improving function[10].

• Night Sweats And Sleep Disruption. Hormone shifts can lead to night sweats that cause discomfort and disrupt. However, omega-3 supplements may help alleviate night sweats, which in turn can lead to more comfortable, less fragmented sleep[11].

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.

References

1. Cho L, Kaunitz AM, Faubion SS, Hayes SN, Lau ES, Pristera N, Scott N, Shifren JL, Shufelt CL, Stuenkel CA, Lindley KJ; ACC CVD in Women Committee. Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long? Circulation. 2023 Feb 14;147(7):597-610. doi: 10.1161/ CIRCULATIONAHA.122.061559. Epub 2023 Feb 13. PMID: 36780393; PMCID: PMC10708894.

2. Members, M. (2024, September 3). Ongoing individualized hormone therapy appears to have no age limit. The Menopause Society. https://menopause. org/press-releases/ongoing-individualized-hormone-therapy-appears-tohave-no-age-limit

3. How to manage menopause naturally. (2022, October 4). https://www.ncoa. org/article/5-ways-to-manage-your-menopause-naturally/

4. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002 Oct;88(4):411-20. doi: 10.1079/BJN2002689. PMID: 12323090.

5. Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr. 2004 Nov;80(5):1167-74. doi: 10.1093/ajcn/80.5.1167. PMID: 15531662.

6. Childs, C. E., Romeu-Nadal, M., Burdge, G. C., & Calder, P. C. (2008). Gender differences in the n-3 fatty acid content of tissues. Proceedings of the Nutrition Society, 67(1), 19-27.

7. El Khoudary SR, Aggarwal B, Beckie TM, Hodis HN, Johnson AE, Langer RD, Limacher MC, Manson JE, Stefanick ML, Allison MA; American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention; and Council on Cardiovascular and Stroke Nursing. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association. Circulation. 2020 Dec 22;142(25):e506-e532. doi: 10.1161/ CIR.0000000000000912. Epub 2020 Nov 30. PMID: 33251828.

8. Khan SU, Lone AN, Khan MS, Virani SS, Blumenthal RS, Nasir K, Miller M, Michos ED, Ballantyne CM, Boden WE, Bhatt DL. Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis. EClinicalMedicine. 2021 Jul 8;38:100997. doi: 10.1016/j.eclinm.2021.100997. PMID: 34505026; PMCID: PMC8413259.

9. Mac Giollabhui N, Mischoulon D, Dunlop BW, Kinkead B, Schettler PJ, Liu RT, Okereke OI, Lamon-Fava S, Fava M, Rapaport MH. Individuals with depression exhibiting a pro-inflammatory phenotype receiving omega-3 polyunsaturated fatty acids experience improved motivation-related cognitive function: Preliminary results from a randomized controlled trial. Brain Behav Immun Health. 2023 Jul 7;32:100666. doi: 10.1016/j.bbih.2023.100666. PMID: 37503359; PMCID: PMC10368827.

10. Deng W, Yi Z, Yin E, Lu R, You H, Yuan X. Effect of omega-3 polyunsaturated fatty acids supplementation for patients with osteoarthritis: a meta-analysis. J Orthop Surg Res. 2023 May 24;18(1):381. doi: 10.1186/s13018-023-03855-w. PMID: 37226250; PMCID: PMC10210278.

11. Mohammady M, Janani L, Jahanfar S, Mousavi MS. Effect of omega-3 supplements on vasomotor symptoms in menopausal women: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2018 Sep;228:295-302. doi: 10.1016/j.ejogrb.2018.07.008. Epub 2018 Jul 20. PMID: 30056356.

12. Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

13. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

14. Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016. Epub 2015 Dec 12. PMID: 27012633.

Application Concept in Dietary Supplements/Functional Foods

MALE FERTILITY AND REPRODUCTIVE HEALTH

CHIA OIL + UBIQUINOL (COQ10)

The highest plant-based source of alpha-linoleic acid (ALA) joins forces with the most active form of coenzyme Q10 to support sperm quality, modulate male reproductive hormones, and support vascular health.

RECOMMENDED FOR Men

Global rates of male fertility have steadily decreased since 1990

15% of couples worldwide are affected by infertility

Male factors contribute to about 50% of infertility cases

COMPOSITION/NUTRITION FACTS

1,200 mg

Alpha-linoleic Acid

200 mg Ubiquinol (CoQ10)

Improves sperm quality, modulates hormone health, reduces inflammation

Exerts anti-inflammatory effect; improves sperm density, motility, and morpholog

RECOMMENDED INTAKE

Two capsules daily

SUGGESTED FORMAT

Softgel capsules

NUTRIENT CONTENT CLAIMS*

• Excellent Source of Omega-3 | USA

• High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS*

Alpha-Linolenic Acid and Q10 | USA

• Optimizes fertility

• Supports sperm health

• Supports vascular and heart health

Alpha-Linolenic Acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels.

KEY ADVANTAGES

• Sustainable

• Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Omega-3 supplements can play a key role in supporting male fertility through a number of different avenues, emerging research suggests. Combining omega-3s with ubiquinol may offer additional anti-inflammatory benefits.

Sperm Motility: Ability of sperm to move efficiently

Sperm Morphology: The shape and structure of sperm cells

Sperm Density: Number of sperm in a given volume of semen

Functional Competence: Ability of sperm to fertilize an egg

THE EVIDENCE: OMEGA-3S

May improve sperm quality.

Higher levels of omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are tied to higher sperm counts and greater sperm motility and morphology. Omega-3 supplements may also help sperm maintain their structural integrity and functional competence by fighting against oxidative stress.

May modulate hormone production. EPA and DHA supplementation may enhance the production of the male reproductive hormone testosterone. That may provide a healthier environment for sperm production and maturation.

May reduce inflammation.

Omega-3's anti-inflammatory properties counteract the effects of chronic inflammation in the testes and the seminal vesicles. This also supports healthy sperm production and function.

THE EVIDENCE: UBIQUINOL (COENZYME Q10)

Men with unexplained low sperm count may benefit from ubiquinol. Supplements can exert an antioxidant effect that has been shown to improve sperm density, sperm motility, and sperm morphology.

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. But methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels in the body.

References

1. Sengupta P, Borges E Jr, Dutta S, Krajewska-Kulak E. Decline in sperm count in European men during the past 50 years. Hum Exp Toxicol. 2018 Mar;37(3):247255. doi: 10.1177/0960327117703690. Epub 2017 Apr 17. PMID: 28413887.

2. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. [Updated 2024 Feb 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562258/

3. Huang B, Wang Z, Kong Y, Jin M, Ma L. Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study. BMC Public Health. 2023 Nov 8;23(1):2195. doi: 10.1186/s12889-023-16793-3. PMID: 37940907; PMCID: PMC10631182.

4. Jensen TK, Priskorn L, Holmboe SA, Nassan FL, Andersson AM, Dalgård C, Petersen JH, Chavarro JE, Jørgensen N. Associations of Fish Oil Supplement Use With Testicular Function in Young Men. JAMA Netw Open. 2020 Jan 3;3(1):e1919462. doi: 10.1001/jamanetworkopen.2019.19462. PMID: 31951274; PMCID: PMC6991322.

5. Attaman JA, Toth TL, Furtado J, Campos H, Hauser R, Chavarro JE. Dietary fat and semen quality among men attending a fertility clinic. Hum Reprod. 2012 May;27(5):1466-74. doi: 10.1093/humrep/des065. Epub 2012 Mar 13. PMID: 22416013; PMCID: PMC3329193

6. Munira, S. M., Lasker, N., Laila, R., Akter, A., Banu, J., & Ishrat, S. (2024). Effect of omega 3 fatty acid in infertile males with oligozoospermia. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 13(2), 270–276. https://doi.org/10.18203/2320-1770.ijrcog20240121

7. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the Reduced Form of Coenzyme Q10 (Ubiquinol) on Semen Parameters in Men with Idiopathic Infertility: a Double-Blind, Placebo Controlled, Randomized Study. Journal of Urology [Internet]. 2012 Aug 1 [cited 2024 Nov 27];188(2):526–31.

8. Metherel AH, Irfan M, Chouinard-Watkins R, Trépanier MO, Stark KD, Bazinet RP. DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in LongEvans Rats. Journal of Nutrition [Internet] 2019 Apr 1 [cited February 13, 2025];149(4):586-595. doi: 10.1093/jn/nxy282. PMID: 30715388.

9. Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

10. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

11. Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016. Epub 2015 Dec 12. PMID: 27012633.

DIETARY SUPPLEMENTS

Application Concept in Dietary Supplements/Functional Foods

POST-WORKOUT ALA SMOOTHIE FOR SPORTS RECOVERY

ANTI-INFLAMMATORY CHIA OIL SMOOTHIE

Optimize sports recovery and shorten time between workouts with a convenient, ready-to-drink smoothie with alpha-linolenic (ALA) omega-3 fatty acids, high-quality protein, and natural antioxidants.

RECOMMENDED FOR

High-performance athletes

INGREDIENTS

Mixed berry juice from concentrate, whey protein, pectin, Benexia Chia Oil (63% ALA), natural raspberry flavor, sunflower seed protein, rosemary extract, tocopherols.

COMPOSITION/NUTRITION FACTS

Supplement Facts

Serving Size: 1 (8.45 FL OZ) (250 mL)

* The % Daily Value tells you how much a nutrient in a

RECOMMENDED INTAKE

One serving (250 ml ) up to twice per day.

SUGGESTED FORMAT

250 ml bottle (1 dosage).

Athletes may be at higher risk for omega-3 insufficiencies.1

Omega-3 supplementation can improve deficiencies and yield performance and recovery benefits.

1600 mg Omega-3 ALA for

High Athletic Performance Muscle Repair, Refuel & Recovery

NUTRIENT CONTENT CLAIMS

Excellent Source of Omega-3 | USA

High in Omega-3 Fatty Acids | EU

Excellent Source of Protein | USA High Protein | EU

HEALTH CLAIMS*

Alpha-Linolenic Acid | USA

• Strengthen heart health for cardiovascular support

• Support immune system

Alpha-Linolenic Acid | EU ALA contributes to the maintenance of normal blood cholesterol levels.

KEY ADVANTAGES

• Sustainable

• Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Omega-3s may help athletes perform at a higher level during physical activity and experience faster recovery times with less muscle discomfort.

THE EVIDENCE: ALAS AND MUSCLE PERFORMANCE

High consumption of ALA (1.9 g/day) is tied to better aerobic performance compared to low consumption of ALA (0.75 g/day). ALA has been shown to improve oxygen use efficiency. It also promotes the use of fat for energy during prolonged exercise after carbohydrate sources have been depleted. 2

THE EVIDENCE: OMEGA-3S AND RECOVERY

Omega-3 supplementation may turn down the body's inflammatory response and decrease oxidative stress after exercise. This may reduce exercise-induced muscle damage, which in turn may support faster recovery times. 3

THE EVIDENCE: OMEGA-3S + WHEY PROTEIN

High-quality protein sources like whey have long been known to support muscle recovery after physical activity. Consuming whey with omega-3 fatty acids before exercising may add to these benefits. The combination has been shown to improve strength and power and reduce delayed-onset muscle soreness. 4

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels. 5,6,7

References

1. Jäger R, Heileson JL, Abou Sawan S, Dickerson BL, Leonard M, Kreider RB, Kerksick CM, Cornish SM, Candow DG, Cordingley DM, Forbes SC, Tinsley GM, Bongiovanni T, Cannataro R, Campbell BI, Arent SM, Stout JR, Kalman DS, Antonio J. International Society of Sports Nutrition Position Stand: Long-Chain Omega-3 Polyunsaturated Fatty Acids. J Int Soc Sports Nutr. 2025 Dec;22(1):2441775. doi: 10.1080/15502783.2024.2441775. Epub 2025 Jan 15. PMID: 39810703; PMCID: PMC11737053.

2. Lyudinina, A.Y., Bushmanova, E.A., Varlamova, N.G. et al. Dietary and plasma blood α-linolenic acid as modulators of fat oxidation and predictors of aerobic performance. J Int Soc Sports Nutr 17, 57 (2020). https://doi.org/10.1186/ s12970-020-00385-2

3. Fernández-Lázaro D, Arribalzaga S, Gutiérrez-Abejón E, Azarbayjani MA, Mielgo-Ayuso J, Roche E. Omega-3 Fatty Acid Supplementation on PostExercise Inflammation, Muscle Damage, Oxidative Response, and Sports Performance in Physically Healthy Adults-A Systematic Review of Randomized Controlled Trials. Nutrients. 2024 Jun 27;16(13):2044. doi: 10.3390/ nu16132044. PMID: 38999792; PMCID: PMC11243702.

4. Ahmadi M, Hoorang N, Imanian B, Hemmatinafar M, Rezaei R, Nemati J, Eftekhari F, Alkasasbeh WJ. Boosting Recovery: Omega-3 and Whey Protein Enhance Strength and Ease Muscle Soreness in Female Futsal Players. Nutrients. 2024 Dec 11;16(24):4263. doi: 10.3390/nu16244263. PMID: 39770885; PMCID: PMC11678206.

5. Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

6. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

7. Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016. Epub 2015 Dec 12. PMID: 27012633.

ALA POWDER

Application Concept in Dietary Supplements/Functional Foods

INSTANT PORRIDGE

NUTRIENT BLEND FOR ELDERLY

EASY-MIX CHIA OIL POWDER

Cognitive and neurologic support from alpha-linolenic acid (ALA) omega-3s for older adults, offered in a highly bioavailable, tasty stir-and-serve porridge.

RECOMMENDED FOR

Senior adults

INGREDIENTS

Benexia® ALA Powder 40 [Chia Oil (70%), Acacia Gum (30%)], quinoa flour, rice flour, modified corn starch, pea protein, calcium carbonate, vitamins and minerals, inulin, natural banana flavor, arabic gum, tocopherols, ascorbil palmitate, guar gum.

COMPOSITION/NUTRITION FACTS

Per 4 tablespoons (50 g) powder (250 g reconstituted product):

Nutrition Facts

Serving size (250 g reconstituted product)

RECOMMENDED INTAKE

Four tablespoons (50 g) prepared with 200ml of milk, water, or any nutritional formula up to twice daily.

The world's older population (ages 60+) will jump by 56% in the next 10 years.1

The number of older adults with dementia worldwide is projected to double by 2030, reaching 78 million. 2

Dietary supplements are widely recognized as a way to enhance cognitive ability and prevent or slow decline. 3

SUGGESTED FORMAT

300g pack (6 servings).

NUTRIENT CONTENT CLAIMS*

Excellent Source of Omega-3 | USA

High Omega-3 Fatty Acids | EU

With more than 600 mg of omega-3 ALA per serving

HEALTH CLAIMS*

Alpha-linolenic acid | USA

• ALA omega-3s promote cardiovascular health

• ALA omega-3s may support immune health

Alpha-linolenic acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels.

The Science

IN SUMMARY: In summary: Adequate or supplementary ALA omega-3s may offer protection for older adults against cognitive declines and neurologic conditions like stroke.

THE EVIDENCE: ALA OMEGA-3S AND COGNITIVE DECLINE

• Dietary intake of omega-3 fatty acids during older adulthood may reduce the risk of all-cause dementia or cognitive decline by 20%. 4

• ALA supplementation during midlife, years before the onset of Alzheimer's disease (AD) symptoms may help prevent or ameliorate slowed brain glucose metabolism, which contributes to the development of AD. 5

THE EVIDENCE: ALA OMEGA-3S AND NEUROLOGIC PROTECTION

• ALA supplementation supports brain health and increases antioxidant activity by increasing levels of brain-derived neurotrophic factors (BDNF), which promotes the growth of new nerve cells in the brain.6

• Low levels of BDNF may increase stroke risk and inhibit stroke recovery, while targeting BDNF levels may support stroke recovery7, suggesting that ALA may support recovery from neurologic conditions like stroke. 8

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.9,10,11

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

1. Pais R, Ruano L, P Carvalho O, Barros H. Global Cognitive Impairment Prevalence and Incidence in Community Dwelling Older Adults-A Systematic Review. Geriatrics (Basel). 2020 Oct 27;5(4):84. doi: 10.3390/ geriatrics5040084. PMID: 33121002; PMCID: PMC7709591.

2. ADI - Dementia statistics. (n.d.). https://www.alzint.org/about/dementiafacts-figures/dementia-statistics/

3. Fekete M, Lehoczki A, Tarantini S, Fazekas-Pongor V, Csípő T, Csizmadia Z, Varga JT. Improving Cognitive Function with Nutritional Supplements in Aging: A Comprehensive Narrative Review of Clinical Studies Investigating the Effects of Vitamins, Minerals, Antioxidants, and Other Dietary Supplements. Nutrients. 2023 Dec 15;15(24):5116. doi: 10.3390/nu15245116. PMID: 38140375; PMCID: PMC10746024.

4. Wei BZ, Li L, Dong CW, Tan CC; Alzheimer’s Disease Neuroimaging Initiative; Xu W. The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers. Am J Clin Nutr. 2023 Jun;117(6):1096-1109. doi: 10.1016/j.ajcnut.2023.04.001. Epub 2023 Apr 5. PMID: 37028557; PMCID: PMC10447496.

5. Lázaro I, Grau-Rivera O, Suárez-Calvet M, Fauria K, Minguillón C, Shekari M, Falcón C, García-Prat M, Huguet J, Molinuevo JL, Gispert JD, Sala-Vila A; ALFA study. Omega-3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia. Alzheimers Dement (Amst). 2024 Jul 5;16(3):e12596. doi: 10.1002/dad2.12596. PMID: 38974876; PMCID: PMC11224768.

6. Hadjighassem, M., Kamalidehghan, B., Shekarriz, N. et al. Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans. Nutr J 14, 20 (2015). https://doi.org/10.1186/s12937-015-0012-5

7. Liu W, Wang X, O'Connor M, Wang G, Han F. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities. Neural Plast. 2020 Jan 27;2020:1969482. doi: 10.1155/2020/1969482. PMID: 32399020; PMCID: PMC7204205.

8. Hadjighassem, M., Kamalidehghan, B., Shekarriz, N. et al. Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans. Nutr J 14, 20 (2015). https://doi.org/10.1186/s12937-015-0012-5

9. Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

10. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

11. Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016. Epub 2015 Dec 12. PMID: 27012633.

Application Concept in Dietary Supplements/Functional Foods

CHIA FIBER AND XYLOGLUCANS FOR IRRITABLE BOWEL SYNDROME

CHIA FIBER + XYLOGLUCANS CAPSULES

The combination of Xyloglucans and Chia fiber significantly improved stool consistency, IBS symptoms (abdominal pain, bloating, discomfort), and quality of life. Additionally, Xyloglucans and Chia Fiber treatment restored serum zonulin concentrations to within normal ranges, suggesting an improvement in intestinal barrier function.

RECOMMENDED FOR

Adults with Irritable Bowel Syndrome or constipation

Irritable bowel syndrome (IBS) is a functional bowel disorder classified among the Disorders of Gut–Brain Interaction (DGBI)1

IBS affects approximately 4–10% of the global population. 2 A subset of IBS, IBS with constipation (IBS-C), accounts for

about 30% of IBS cases.

INGREDIENTS

Xia Powder 435 W LM (chia fiber), High purity Xyloglucan (tamarind).

COMPOSITION/NUTRITION FACTS

Per sachet (10g):

RECOMMENDED INTAKE

One sachet up to twice per day

SUGGESTED FORMAT

10g sachet/stick

NUTRIENT CONTENT CLAIMS*

• Good Source of Omega-3 /EU

• High in Omega-3 Fatty Acids /USA

• High in Fiber /USA /EU

FUNCTION/ STRUCTURE CLAIMS*

• Digestive Regularity 5

• Prebiotic Effect 6

• Glucose Management4

• Appetite Control3

• Cholesterol support4

KEY ADVANTAGES

• Chia fiber contains:

- up to 56% of total fiber, including both soluble and insoluble types

- Alpha-linoleic acid (ALA, an essential omega-3 fatty acid)

• 100% natural with no additives

Chia Fiber Xyloglucans

The Science

IN SUMMARY: The combination of Xyloglucans and Chia fiber significantly improved stool consistency, IBS symptoms (abdominal pain, bloating, discomfort), and quality of life compared to the placebo. Additionally, Xyloglucans and Chia Fiber treatment restored serum zonulin concentrations to within normal ranges, suggesting an improvement in intestinal barrier function.7

THE EVIDENCE: CHIA FIBER AND XYLOGLUCANS

A recent study demonstrated that Xyloglucans and Chia Fiber significantly improves abdominal pain, bloating, discomfort, and stool consistency in patients with IBS-C. It also led to a reduction in serum zonulin concentrations, suggesting a potential role in restoring intestinal barrier integrity and permeability. XP+CS was a safe therapeutic option that significantly improved the quality of life and psychological well-being of IBS-C patients.

The positive effects of Xyloglucans and Chia Fiber on stool consistency, IBS symptoms, and quality of life were observed as early as 15 days from treatment onset.

This is particularly relevant given that many existing treatments for IBS-C are ineffective in managing all symptoms and improving quality of life. Unlike some laxatives or certain fibers that can cause side effects or worsen symptoms, Xyloglucans and Chia Fiber normalized stool consistency without causing diarrhea or other adverse effects.

The study also found a weak correlation between serum zonulin concentration and IBS symptoms (specifically constipation), supporting the growing evidence that barrier dysfunction plays a role in IBS-C pathophysiology.

This study provides clinical evidence for the gastrointestinal effects of chia fiber in combination with xyloglucan. This therapy is safe, well-tolerated, and effective in controlling constipation, abdominal pain, and bloating in IBS-C patients, significantly improving their quality of life.

References

1. Mearin, F.; Lacy, B.E.; Chang, L.; Chey, W.D.; Lembo, A.J.; Simren, M.; Spiller, R. Bowel Disorders. Gastroenterology 2016, 150, 1393–1407.

2. Sperber, A.D.; Bangdiwala, S.I.; Drossman, D.A.; Ghoshal, U.C.; Simren, M.; Tack, J.; Whitehead,W.E.; Dumitrascu, D.L.; Fang, X.; Fukudo, S.; et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study. Gastroenterology 2021, 160, 99–114.e3.

3. Aylin Ayaz, Asli Akyol, Elif Inan-Eroglu, Arzu Kabasakal Cetin, Gulhan Samun and Filiz Akbiyik. Chia seed (Salvia Hispanica L.) added yogurt reduces short-term food intake and increases satiety: randomized controlled trial. Nutrition Research and Practice 2017;11(5):412-418

4. Alba Tamargo, Diana Martin, Joaquín Navarro del Hierro, M. Victoria Moreno-Arribas, Loreto A. Muñoz, Intake of soluble fibre from chia seed reduces bioaccessibility of lipids, cholesterol and glucose in the dynamic gastrointestinal model simgi®, Food Research International, Volume 137, 2020.

5. Gotterland, M; Evaluation of the digestive tolerance to a high-fiber “chia flour” (Salvia hispánica L.) in asymptomatic volunteers. (2019)

6. Alba Tamargo, Carolina Cueva, Laura Laguna, M.Victoria Moreno-Arribas, Loreto A. Muñoz, Understanding the impact of chia seed mucilage on human gut microbiota by using the dynamic gastrointestinal model simgi®, Journal of Functional Foods, Volume 50, 2018, pages 104-111.

7. Armova, M.; Nikolova, M.S.; Draganov, P.M.; Peneva, P.V.; Sabaté, J.M.; Santos, J. Efficacy and Safety of Chia Seed Powder, Pea Protein, and Xyloglucan in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial. Gastrointest. Disord. 2025, 7, 19.

Benexia®, a leader in the industry

Launched in 2000, Benexia® is a world leader in the production, processing, and commercialization of chia and chia-based ingredients. Our company is vertically integrated from agricultural production to final ingredients and solutions, including plant cultivation, extraction, concentration processes, and ingredients development.

We guarantee traceability from the fields and certified quality (GAP, GMP-HACCP, and FSSC 22000). Benexia products are certified Halal and Kosher.

Sustainability and Corporate Responsibility

Benexia employs regenerative agriculture to achieve lower carbon and water footprints from planting to harvesting. These practices are incorporated by the brand's farming partners in Bolivia, Argentina, and Paraguay. Harvested chia seeds are processed without the use of gas or water. Seeds are cleaned and separated using physical processes such as airflow and density-based separation methods, yielding a final seed product that's 99.95% pure.

Since its founding in 2005, Benexia is dedicated to supporting the welfare of its local communities. Benexia is aligned with the United Nations' Sustainability Development Goals and is on track to complete its B Corp certification by 2025. Half of Benexia's partner shareholders are chia farmers. This guarantees fair pricing and technical support within the company's supply chain as well as full traceability of ingredients.

Our team, the best customer service

We're passionate about health, wellbeing, and providing exceptional service for our customers. We offer support in formulation, nutrition, scientific and regulatory matters, with the best experts to assist your needs.

Contact us for samples, application sheets and more information at info@benexia.com

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