BENEXIA Xia Oil Science-Based Applications

Chia Oil

Science-Based Application Concepts BONE HEALTH MENOPAUSE & POST MENOPAUSE SUPPORT MALE FERTILITY SPORTS NUTRITION & RECOVERY COGNITION & NEUROLOGICAL SUPPORT FOR ELDERLY GUT HEALTH & IBS SUPPORT & OTHER APPLICATION CONCEPTS IN FUNCTIONAL LIPIDS BLENDS

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

1

Application Concept in Dietary Supplements/Functional Foods BONE HEALTH FOR POSTMENOPAUSAL WOMEN

CALCIUM + VITAMIN D + CHIA OIL ALA POWDER

INGREDIENTS

Calcium and vitamin D are essential for healthy bones.

Benexia ALA Powder 40 (microencapsulated chia oil [70%],

Combining these key nutrients with the highest

acacia gum [30%]), Calcium carbonate, vitamin D, natural

plant-based source of alpha-linolenic acid (ALA) may

flavor and color.

support strong bones and reduce joint inflammation as women age.

COMPOSITION/NUTRITION FACTS

RECOMMENDED FOR Women 50 and older

1 in 4 postmenopausal women in both Europe and the U.S. have osteoporosis

Alpha-Linoleic Acid

1.4 g

Calcium

400 mg (33% RDA)

Vitamin D

5,000 IU

RECOMMENDED INTAKE One 15-g scoop per day

1 in 3 women will have an osteoporotic

SUGGESTED FORMAT

fracture in their lifetime

450g (15.9 oz) jar (30 dosages) NUTRIENT CONTENT CLAIMS*

Fragility-related fractures may increase by 25% by 2034

•

Excellent source of omega-3s | USA

•

High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS* Alpha-Linolenic Acid and Calcium | USA •

Minimizes bone loss

•

Supports joint health

•

Reduces inflammation

Alpha-Linolenic Acid | EU ALA contributes to the maintenance of normal blood cholesterol levels.

Calcium | EU Calcium helps reduce bone mineral loss in postmenopausal women KEY ADVANTAGES •

Sustainable

•

Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science IN SUMMARY: Pairing omega-3s with calcium and vitamin D can offer additional bone and joint protection for women ages 50 and older. The benefits from ALA omega-3s may be greater than other forms of omega-3 supplementation such as DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid).

THE EVIDENCE: OMEGA-3S

BONE METABOLISM

May enhance calcium absorption

The continuous process of forming

Omega-3 fatty acids may alter the lipid composition of cell membranes, helping cells take in more calcium that can

new bone tissue and breaking down,

then be put towards building and maintaining bone tissue.

or resorbing, old or damaged bone

These alterations may also reduce rates of calcium loss.

tissue to help bones maintain their

May reduce inflammation to reduce bone loss and

structural integrity.

enhance bone growth Rates of low-grade inflammation naturally increase with age. Omega-3s offer protection by turning down the production of pro-inflammatory cytokines that may stimulate the breakdown, or resorption, or bone tissue.

THE EVIDENCE: ALA VS. DHA

Simultaneously, these anti-inflammatory properties may

When it comes to getting our fill of omega-3s, ALA alone

also stimulate the formation of healthy new bone tissue.

may be able to get the job done. Experts have long

ALA omega-3 may be particularly effective at these tasks.

Compared to supplementing with DHA and EPA, ALA supplementation is tied to: •

Significantly higher levels of Bone-specific alkaline phosphatase (BALP), a bone enzyme involved in generating new bone tissue.

•

Lower levels of markers of bone resorption, such as C-terminal telopeptide of type 1 collagen (CTX) and N-terminal telopeptide (NTx).

May enhance physical function Greater physical activity supports stronger, healthier bones. Among postmenopausal women, dietary intake of ALA omega-3 has been shown to positively impact key parameters of physical function in just three days,

believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, we know that women's bodies are more efficient than men, with a conversion rate of 21% for EPA and 9% for DHA. More significantly, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day.

That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.

including faster walking speed, greater grip strength, lower fat mass, better balance, and increased squatting ability.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

3

References 1.

Office of the Commissioner. (2024, May 13). Osteoporosis. U.S. Food And Drug Administration. https://www.fda.gov/consumers/womens-health-topics/ osteoporosis.

2.

Cooper, C., Halbout, P., Reginster, J.-Y., & Kanis, J. A. (2021). SCORECARD FOR OSTEOPOROSIS IN EUROPE. In SCOPE 2021 Summary Report. https://www. osteoporosis.foundation/sites/iofbonehealth/files/2022-01/SCOPE%20 Summary%20Report.pdf

3.

Liu Z, Cai S, Chen Y, Peng Z, Jian H, Zhang Z, Huang H. The association between dietary omega-3 intake and osteoporosis: a NHANES cross-sectional study.

Front Nutr. 2025 Jan 10;11:1467559. doi: 10.3389/fnut.2024.1467559. PMID: 39867554; PMCID: PMC11757016.

4.

Dou Y, Wang Y, Chen Z, Yu X, Ma D. Effect of n-3 polyunsaturated fatty acid on bone health: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr. 2021 Nov 29;10(1):145-154. doi: 10.1002/fsn3.2655.

PMID: 35035917; PMCID: PMC8751426.

5.

Troy KL, Mancuso ME, Butler TA, Johnson JE. Exercise Early and Often: Effects of Physical Activity and Exercise on Women's Bone Health. Int J Environ Res Public Health. 2018 Apr 28;15(5):878. doi: 10.3390/ijerph15050878. PMID: 29710770; PMCID: PMC5981917.

6.

Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct Target Ther. 2023 Jun 8;8(1):239. doi: 10.1038/s41392-023-01502-8. PMID: 37291105; PMCID: PMC10248351.

7.

Isanejad, M., Tajik, B., McArdle, A. et al. Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65–72 years. Eur J Nutr 61, 1813–1821 (2022). https://doi.org/10.1007/s00394-021-02773-Z.

8.

Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

9.

Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

10.

Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016.

Epub 2015 Dec 12. PMID: 27012633.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

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Application Concept in Dietary Supplements/Functional Foods FUNCTIONAL COLLAGEN PEPTIDES POWDER FOR POST-MENOPAUSAL WOMEN EASY-MIX CHIA OIL + COLLAGEN PEPTIDES POWDER

INGREDIENTS

Alpha-linolenic acid (ALA), highly hydrolyzed bovine

Hydrolyzed bovine collagen peptides,

collagen peptides, and calcium combine synergistically

Benexia® ALA Powder 40 [chia oil (70%), acacia gum (30%)],

to offer joint protection and bone and anti-inflammatory

calcium carbonate].

support in a highly bioavailable, easy-to-mix drink powder.

COMPOSITION/NUTRITION FACTS

RECOMMENDED FOR

•

1,400 mg ALA omega-3s

Women ages 50+

•

10 g hydrolyzed bovine collagen peptides

•

400 mg calcium (31% VRN)

1400 mg Omega-3 ALA to

In the U.S., 6,000 women enter menopause each day.1

Musculoskeletal pain increases with age and may be tied to the onset of menopause. 2

Boost Physical Function

Reduce Low-Grade Inflammation

RECOMMENDED INTAKE One scoop (15 grams) daily for at least 3 months SUGGESTED FORMAT 450g (15.9 oz. 0.99lb) jar (30 dosages) NUTRIENT CONTENT CLAIMS* Excellent Source of Omega-3 | USA High in Omega-3 Fatty Acids | EU HEALTH CLAIMS: Alpha-linolenic acid | USA ALA omega-3s promote cardiovascular health Alpha-linolenic acid | EU ALA contributes to the maintenance of normal blood cholesterol levels Calcium | EU Calcium helps reduce the loss of bone mineral in postmenopausal women

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science IN SUMMARY: Declines in the hormone estrogen can lead to or worsen joint pain during and after menopause. Dietary ALA omega-3s may improve joint health and physical capacity in older women, making them an effective way to delay and/ or prevent declines in function.

THE EVIDENCE: ALA AND ENHANCED

THE EVIDENCE: ALA VS. DHA

PHYSICAL FUNCTION

When it comes to getting our omega-3 needs met, ALA

•

Women with higher dietary ALA intake show

alone may be able to get the job done. Experts have

enhanced physical function parameters including

long believed that DHA and EPA are the "hero" sources

faster walking speed, greater grip strength, lower fat

of omega-3 fatty acids, since ALA was thought to have

mass, and better balance and squatting ability. 3

a poor rate of conversion to DHA. However, methods of

Supplementing with omega-3 fatty acids has

measuring rates of ALA conversion have advanced. Using

consistently been shown to relieve joint pain while

novel tracking strategies, scientists are now learning that

improving function.

DHA is stored in the body's tissues long-term, and only a

•

4

THE EVIDENCE: ALA REDUCES LOW-GRADE INFLAMMATION ALA reduces levels of low-grade inflammation that naturally increase with aging and contribute to musculoskeletal joint pain and functional declines.5

small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.9,10,11

THE EVIDENCE: OMEGA-3S SUPPORTS MUSCLE HEALTH Omega-3s contributes to muscle protein synthesis. This can help prevent age-related muscle loss that can lead to frailness.6 THE EVIDENCE: OMEGA-3S AND HEART HEALTH Estrogen exerts a protective effect on the heart, where declining levels can increase a woman's risk for heart disease, heart attack, and stroke.7 Supplemental omega-3 can play a key role in combatting these problems by aiding in BMI and waist circumference reduction and lower blood pressure and triglycerides.8

REFERENCES Scan the QR code to access scientific references and claim validations.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

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The Science IN SUMMARY: Declines in the hormone estrogen can lead to or worsen joint pain during and after menopause. Dietary ALA omega-3s may improve joint health and physical capacity in older women, making them an effective way to delay and/ or prevent declines in function.

THE EVIDENCE: ALA AND ENHANCED

THE EVIDENCE: ALA VS. DHA

PHYSICAL FUNCTION

When it comes to getting our omega-3 needs met, ALA

•

Women with higher dietary ALA intake show

alone may be able to get the job done. Experts have

enhanced physical function parameters including

long believed that DHA and EPA are the "hero" sources

faster walking speed, greater grip strength, lower fat

of omega-3 fatty acids, since ALA was thought to have

mass, and better balance and squatting ability. 3

a poor rate of conversion to DHA. However, methods of

Supplementing with omega-3 fatty acids has

measuring rates of ALA conversion have advanced. Using

consistently been shown to relieve joint pain while

novel tracking strategies, scientists are now learning that

improving function.

DHA is stored in the body's tissues long-term, and only a

•

4

THE EVIDENCE: ALA REDUCES LOW-GRADE INFLAMMATION ALA reduces levels of low-grade inflammation that naturally increase with aging and contribute to musculoskeletal joint pain and functional declines.5 THE EVIDENCE: OMEGA-3S SUPPORTS MUSCLE HEALTH Omega-3s contributes to muscle protein synthesis. This can help prevent age-related muscle loss that can lead to frailness.6 THE EVIDENCE: OMEGA-3S AND HEART HEALTH Estrogen exerts a protective effect on the heart, where declining levels can increase a woman's risk for heart disease, heart attack, and stroke.7 Supplemental omega-3 can play a key role in combatting these problems by aiding in BMI and waist circumference reduction and lower blood pressure and triglycerides.8

small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.9,10,11

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

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Application Concept in Dietary Supplements/Functional Foods OMEGA-3 BOOSTER FOR MENOPAUSE SUPPORT

CHIA + ALGAE OIL NUTRITIONAL DROPS

INGREDIENTS

Shifts in the hormone estrogen can cause unpleasant

Chia seed oil, algae oil.

symptoms during the menopausal transition. ALA and DHA omega-3 fatty acids can help manage these

COMPOSITION/NUTRITION FACTS

symptoms and support overall health.

RECOMMENDED FOR Women ages 40 and older for perimenopausal and postmenopausal support.

Alpha-Linoleic Acid (ALA)

2,492 mg

Docosahexaenoic Acid (DHA)

258 mg

RECOMMENDED INTAKE One tsp (5 mL) up to twice per day.

SUGGESTED FORMAT 130 mL (4.3 oz) bottle (26 dosages).

NUTRIENT CONTENT CLAIMS* Excellent Source of Omega-3 | USA High in Omega-3 Fatty Acids | EU HEALTH CLAIMS* Alpha-Linolenic Acid | USA ALA may support the immune system

In the U.S., 6,000 women enter

Alpha-Linolenic Acid | EU

menopause each day

ALA contributes to the maintenance of normal blood

1

cholesterol levels KEY ADVANTAGES •

Sustainable

•

Plant-based source of omega-3s

Up to 80% of women experience menopause symptoms that adversely impact their quality of life and productivity2

Up to 80% of women are short on important nutrients such as omega-3 fatty acids3

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science IN SUMMARY: Women become less effective at converting ALA omega-3s to DHA omega-3s during the menopausal transition. Supplementing with ALA and DHA omega-3s can support this reduced capacity, and in turn, help manage menopause-related symptoms.

THE EVIDENCE: WOMEN AND OMEGA-3 CONVERSION

•

Night Sweats And Sleep Disruption. Hormone shifts

Research shows that younger women convert alpha-

can lead to night sweats that cause discomfort and

linolenic acid (ALA) to eicosapentaenoic acid (EPA) and

disrupt. However, omega-3 supplements may help

docosahexaenoic acid (DHA) much more efficiently

alleviate night sweats, which in turn can lead to more

than men, in large part thanks to estrogen. As estrogen

comfortable, less fragmented sleep[11].

levels decline during menopause, the synthesis of ALA to DHA becomes downregulated, making omega-3 supplementation essential.4,5,6

THE EVIDENCE: ALA VS. DHA When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long

THE EVIDENCE: OMEGA-3S IN MENOPAUSE

believed that DHA and EPA are the "hero" sources of

The menopausal transition is associated with an increased

omega-3 fatty acids, since ALA was thought to have a

risk for a range of symptoms and conditions. Many of

poor rate of conversion to DHA. However, methods of

those issues can be better managed with the help of

measuring rates of ALA conversion have advanced. Using

supplemental omega-3 fatty acids, including:

novel tracking strategies, scientists are now learning that

•

Heart Health. Estrogen exerts a protective effect on the heart, where declining levels can increase a woman's risk for heart disease, heart attack, and stroke[7]. Supplemental omega-3 can play a key role in combatting these problems by aiding in BMI and waist circumference reduction and lower blood

DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.

pressure and triglycerides[8].

•

Mood and Brain Fog. The risk for mood disorders and cognitive impairment increases in menopause.

Research suggests that supplementing with omega-3s can improve depressive symptoms while enhancing critical aspects of cognition related to motivation, such as energy and alertness[9].

•

Joint Pain. Thanks to hormone shifts and the natural effects of aging, more than half of women experience joint pain during and after menopause.

Supplementing with omega-3 fatty acids has consistently been shown to relieve joint pain while improving function[10].

REFERENCES Scan the QR code to access scientific references and claim validations.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

11

References 1.

Cho L, Kaunitz AM, Faubion SS, Hayes SN, Lau ES, Pristera N, Scott N, Shifren JL, Shufelt CL, Stuenkel CA, Lindley KJ; ACC CVD in Women Committee.

Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long? Circulation. 2023 Feb 14;147(7):597-610. doi: 10.1161/ CIRCULATIONAHA.122.061559. Epub 2023 Feb 13. PMID: 36780393; PMCID: PMC10708894.

2.

Members, M. (2024, September 3). Ongoing individualized hormone therapy appears to have no age limit. The Menopause Society. https://menopause. org/press-releases/ongoing-individualized-hormone-therapy-appears-tohave-no-age-limit

3.

How to manage menopause naturally. (2022, October 4). https://www.ncoa. org/article/5-ways-to-manage-your-menopause-naturally/

4.

Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002 Oct;88(4):411-20. doi: 10.1079/BJN2002689. PMID: 12323090.

5.

Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects.

Am J Clin Nutr. 2004 Nov;80(5):1167-74. doi: 10.1093/ajcn/80.5.1167. PMID: 15531662.

6.

Childs, C. E., Romeu-Nadal, M., Burdge, G. C., & Calder, P. C. (2008). Gender differences in the n-3 fatty acid content of tissues. Proceedings of the Nutrition Society, 67(1), 19-27.

7.

El Khoudary SR, Aggarwal B, Beckie TM, Hodis HN, Johnson AE, Langer RD, Limacher MC, Manson JE, Stefanick ML, Allison MA; American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention; and Council on Cardiovascular and Stroke Nursing.

Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association. Circulation. 2020 Dec 22;142(25):e506-e532. doi: 10.1161/ CIR.0000000000000912. Epub 2020 Nov 30. PMID: 33251828.

8.

Khan SU, Lone AN, Khan MS, Virani SS, Blumenthal RS, Nasir K, Miller M, Michos ED, Ballantyne CM, Boden WE, Bhatt DL. Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis.

EClinicalMedicine. 2021 Jul 8;38:100997. doi: 10.1016/j.eclinm.2021.100997.

PMID: 34505026; PMCID: PMC8413259.

9.

Mac Giollabhui N, Mischoulon D, Dunlop BW, Kinkead B, Schettler PJ, Liu RT, Okereke OI, Lamon-Fava S, Fava M, Rapaport MH. Individuals with depression exhibiting a pro-inflammatory phenotype receiving omega-3 polyunsaturated fatty acids experience improved motivation-related cognitive function: Preliminary results from a randomized controlled trial. Brain Behav Immun Health. 2023 Jul 7;32:100666. doi: 10.1016/j.bbih.2023.100666. PMID: 37503359; PMCID: PMC10368827.

10.

Deng W, Yi Z, Yin E, Lu R, You H, Yuan X. Effect of omega-3 polyunsaturated fatty acids supplementation for patients with osteoarthritis: a meta-analysis. J Orthop Surg Res. 2023 May 24;18(1):381. doi: 10.1186/s13018-023-03855-w.

PMID: 37226250; PMCID: PMC10210278.

11.

Mohammady M, Janani L, Jahanfar S, Mousavi MS. Effect of omega-3 supplements on vasomotor symptoms in menopausal women: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2018 Sep;228:295-302. doi: 10.1016/j.ejogrb.2018.07.008. Epub 2018 Jul 20. PMID: 30056356.

12.

Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

13.

Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

14.

Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016.

Epub 2015 Dec 12. PMID: 27012633.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

13

Application Concept in Dietary Supplements/Functional Foods MALE FERTILITY AND REPRODUCTIVE HEALTH

CHIA OIL + UBIQUINOL (COQ10)

COMPOSITION/NUTRITION FACTS

The highest plant-based source of alpha-linoleic acid (ALA) joins forces with the most active form of coenzyme Q10 to support sperm quality, modulate male reproductive

1,200 mg Alpha-linoleic Acid

200 mg Ubiquinol (CoQ10)

Improves sperm quality, modulates hormone health, reduces inflammation

Exerts anti-inflammatory effect; improves sperm density, motility, and morpholog

hormones, and support vascular health.

RECOMMENDED FOR Men

Global rates of male fertility have steadily decreased since 1990

RECOMMENDED INTAKE

15% of couples worldwide are affected by infertility

Two capsules daily SUGGESTED FORMAT Softgel capsules

Male factors contribute to about 50% of infertility cases

NUTRIENT CONTENT CLAIMS* •

Excellent Source of Omega-3 | USA

•

High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS* Alpha-Linolenic Acid and Q10 | USA •

Optimizes fertility

•

Supports sperm health

•

Supports vascular and heart health

Alpha-Linolenic Acid | EU ALA contributes to the maintenance of normal blood cholesterol levels.

KEY ADVANTAGES •

Sustainable

•

Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science IN SUMMARY: Omega-3 supplements can play a key role in supporting male fertility through a number of different avenues, emerging research suggests. Combining omega-3s with ubiquinol may offer additional anti-inflammatory benefits.

Sperm Motility: Ability of sperm to move efficiently Sperm Morphology: The shape and structure of sperm cells Sperm Density: Number of sperm in a given volume of semen Functional Competence: Ability of sperm to fertilize an egg

THE EVIDENCE: OMEGA-3S May improve sperm quality.

Higher levels of omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are tied to higher sperm counts and greater sperm motility

THE EVIDENCE: UBIQUINOL (COENZYME Q10) Men with unexplained low sperm count may benefit from ubiquinol. Supplements can exert an antioxidant effect that has been shown to improve sperm density, sperm motility, and sperm morphology.

and morphology. Omega-3 supplements may also help

THE EVIDENCE: ALA VS. DHA

sperm maintain their structural integrity and functional

When it comes to getting our fill of omega-3s, ALA alone

competence by fighting against oxidative stress.

may be able to get the job done. Experts have long

May modulate hormone production.

EPA and DHA supplementation may enhance the production of the male reproductive hormone testosterone. That may provide a healthier environment for sperm production and maturation.

believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. But methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small

May reduce inflammation.

fraction of those reserves actually need to be topped off

Omega-3's anti-inflammatory properties counteract

each day. That replenishment hurdle can easily be cleared

the effects of chronic inflammation in the testes and

with daily intake of ALA. While the conversion rate is small,

the seminal vesicles. This also supports healthy sperm

it may actually be all that’s needed to maintain healthy

production and function.

DHA and EPA levels in the body.

REFERENCES Scan the QR code to access scientific references and claim validations.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

15

References 1.

Sengupta P, Borges E Jr, Dutta S, Krajewska-Kulak E. Decline in sperm count in European men during the past 50 years. Hum Exp Toxicol. 2018 Mar;37(3):247255. doi: 10.1177/0960327117703690. Epub 2017 Apr 17. PMID: 28413887.

2.

Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. [Updated 2024 Feb 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562258/

3.

Huang B, Wang Z, Kong Y, Jin M, Ma L. Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study. BMC Public Health. 2023 Nov 8;23(1):2195. doi: 10.1186/s12889-023-16793-3. PMID: 37940907; PMCID: PMC10631182.

4.

Jensen TK, Priskorn L, Holmboe SA, Nassan FL, Andersson AM, Dalgård C, Petersen JH, Chavarro JE, Jørgensen N. Associations of Fish Oil Supplement Use With Testicular Function in Young Men. JAMA Netw Open. 2020 Jan 3;3(1):e1919462. doi: 10.1001/jamanetworkopen.2019.19462. PMID: 31951274; PMCID: PMC6991322.

5.

Attaman JA, Toth TL, Furtado J, Campos H, Hauser R, Chavarro JE. Dietary fat and semen quality among men attending a fertility clinic. Hum Reprod. 2012 May;27(5):1466-74. doi: 10.1093/humrep/des065. Epub 2012 Mar 13. PMID: 22416013; PMCID: PMC3329193

6.

Munira, S. M., Lasker, N., Laila, R., Akter, A., Banu, J., & Ishrat, S. (2024). Effect of omega 3 fatty acid in infertile males with oligozoospermia. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 13(2), 270–276. https://doi.org/10.18203/2320-1770.ijrcog20240121

7.

Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the Reduced Form of Coenzyme Q10 (Ubiquinol) on Semen Parameters in Men with Idiopathic Infertility: a Double-Blind, Placebo Controlled, Randomized Study.

Journal of Urology [Internet]. 2012 Aug 1 [cited 2024 Nov 27];188(2):526–31.

8.

Metherel AH, Irfan M, Chouinard-Watkins R, Trépanier MO, Stark KD, Bazinet RP. DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in LongEvans Rats. Journal of Nutrition [Internet] 2019 Apr 1 [cited February 13, 2025];149(4):586-595. doi: 10.1093/jn/nxy282. PMID: 30715388.

9.

Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

10.

Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

11.

Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016.

Epub 2015 Dec 12. PMID: 27012633.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

17

Application Concept in Dietary Supplements/Functional Foods POST-WORKOUT ALA SMOOTHIE FOR SPORTS RECOVERY ANTI-INFLAMMATORY CHIA OIL SMOOTHIE Optimize sports recovery and shorten time between workouts with a convenient, ready-to-drink smoothie with alpha-linolenic (ALA) omega-3 fatty acids, high-quality

Athletes may be at higher risk for omega-3 insufficiencies.1

protein, and natural antioxidants.

RECOMMENDED FOR

Omega-3 supplementation can improve

High-performance athletes

deficiencies and yield performance and

INGREDIENTS

recovery benefits.

Mixed berry juice from concentrate, whey protein, pectin, Benexia Chia Oil (63% ALA), natural raspberry flavor,

1600 mg Omega-3 ALA for

sunflower seed protein, rosemary extract, tocopherols.

COMPOSITION/NUTRITION FACTS

Supplement Facts

High Athletic Performance

Serving Size: 1 (8.45 FL OZ) (250 mL) Amount per Serving

Daily Value*

Calories

252

Total Fat 8g

10%

Saturated Fat 1.5g

12%

NUTRIENT CONTENT CLAIMS Excellent Source of Omega-3 | USA

Trans Fat 0g

High in Omega-3 Fatty Acids | EU

Monounsaturated Fat 3.7g

Excellent Source of Protein | USA

Polyunsaturated Fat 2.5g

High Protein | EU

Omega-3 ALA 1600 mg Cholesterol 74mg

24.7%

HEALTH CLAIMS*

Sodium 180mg

7.8%

Alpha-Linolenic Acid | USA

Total Carbohydrates 25g Dietary Fiber 1.5g

9% 5.3%

Total Sugars 23g Includes 0g Added Sugars Protein 20g

Muscle Repair, Refuel & Recovery

0% 40%

* The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2000 calories a day is used for general nutrition advice.

RECOMMENDED INTAKE One serving (250 ml ) up to twice per day.

•

Strengthen heart health for cardiovascular support

•

Support immune system

Alpha-Linolenic Acid | EU ALA contributes to the maintenance of normal blood cholesterol levels.

KEY ADVANTAGES • Sustainable • Plant-based source of omega-3s

SUGGESTED FORMAT 250 ml bottle (1 dosage).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science IN SUMMARY: Omega-3s may help athletes perform at a higher level during physical activity and experience faster recovery times with less muscle discomfort.

THE EVIDENCE: ALAS AND MUSCLE PERFORMANCE

THE EVIDENCE: ALA VS. DHA

High consumption of ALA (1.9 g/day) is tied to better

When it comes to getting our fill of omega-3s, ALA alone

aerobic performance compared to low consumption of

may be able to get the job done. Experts have long

ALA (0.75 g/day). ALA has been shown to improve oxygen

believed that DHA and EPA are the "hero" sources of

use efficiency. It also promotes the use of fat for energy

omega-3 fatty acids, since ALA was thought to have a

during prolonged exercise after carbohydrate sources

poor rate of conversion to DHA. However, methods of

have been depleted.

measuring rates of ALA conversion have advanced. Using

2

THE EVIDENCE: OMEGA-3S AND RECOVERY Omega-3 supplementation may turn down the body's inflammatory response and decrease oxidative stress after exercise. This may reduce exercise-induced muscle damage, which in turn may support faster recovery times. 3 THE EVIDENCE: OMEGA-3S + WHEY PROTEIN

novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.5,6,7

High-quality protein sources like whey have long been known to support muscle recovery after physical activity.

Consuming whey with omega-3 fatty acids before exercising may add to these benefits. The combination has been shown to improve strength and power and reduce delayed-onset muscle soreness.4

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

19

References 1.

Jäger R, Heileson JL, Abou Sawan S, Dickerson BL, Leonard M, Kreider RB, Kerksick CM, Cornish SM, Candow DG, Cordingley DM, Forbes SC, Tinsley GM, Bongiovanni T, Cannataro R, Campbell BI, Arent SM, Stout JR, Kalman DS, Antonio J. International Society of Sports Nutrition Position Stand: Long-Chain Omega-3 Polyunsaturated Fatty Acids. J Int Soc Sports Nutr. 2025 Dec;22(1):2441775. doi: 10.1080/15502783.2024.2441775. Epub 2025 Jan 15.

PMID: 39810703; PMCID: PMC11737053.

2.

Lyudinina, A.Y., Bushmanova, E.A., Varlamova, N.G. et al. Dietary and plasma blood α-linolenic acid as modulators of fat oxidation and predictors of aerobic performance. J Int Soc Sports Nutr 17, 57 (2020). https://doi.org/10.1186/ s12970-020-00385-2

3.

Fernández-Lázaro D, Arribalzaga S, Gutiérrez-Abejón E, Azarbayjani MA, Mielgo-Ayuso J, Roche E. Omega-3 Fatty Acid Supplementation on PostExercise Inflammation, Muscle Damage, Oxidative Response, and Sports Performance in Physically Healthy Adults-A Systematic Review of Randomized Controlled Trials. Nutrients. 2024 Jun 27;16(13):2044. doi: 10.3390/ nu16132044. PMID: 38999792; PMCID: PMC11243702.

4.

Ahmadi M, Hoorang N, Imanian B, Hemmatinafar M, Rezaei R, Nemati J, Eftekhari F, Alkasasbeh WJ. Boosting Recovery: Omega-3 and Whey Protein Enhance Strength and Ease Muscle Soreness in Female Futsal Players.

Nutrients. 2024 Dec 11;16(24):4263. doi: 10.3390/nu16244263. PMID: 39770885; PMCID: PMC11678206.

5.

Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

6.

Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

7.

Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016.

Epub 2015 Dec 12. PMID: 27012633.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

21

Application Concept in Dietary Supplements/Functional Foods INSTANT PORRIDGE ABSORPTION-OPTIMIZED NUTRIENT BLEND FOR ELDERLY EASY-MIX CHIA OIL POWDER Cognitive and neurologic support from alpha-linolenic acid (ALA) omega-3s for older adults, offered in a highly

The world's older population (ages 60+) will jump by 56% in the next 10 years.1

bioavailable, tasty stir-and-serve porridge.

The number of older adults with dementia worldwide is projected to double by 2030, reaching 78 million. 2

RECOMMENDED FOR Senior adults INGREDIENTS Benexia® ALA Powder 40 [Chia Oil (70%), Acacia Gum (30%)], quinoa flour, rice flour, modified corn starch, pea protein, calcium carbonate, vitamins and minerals, inulin, natural banana flavor, arabic gum,

Dietary supplements are widely recognized as a way to enhance cognitive ability and prevent or slow decline. 3

tocopherols, ascorbil palmitate, guar gum.

4800 mg Omega-3 ALA for

COMPOSITION/NUTRITION FACTS Per 4 tablespoons (50 g) powder (250 g reconstituted product):

Nutrition Facts

Cognitive support

Serving size (250 g reconstituted product) Amount per Serving

Calories

408 Daily Value*

Total Fat 13.3g

17%

Saturated Fat 3g

15%

Monounsaturated Fat 3g

SUGGESTED FORMAT 300g pack (6 servings).

NUTRIENT CONTENT CLAIMS* Excellent Source of Omega-3 | USA

Polyunsaturated Fat 7.3g

High Omega-3 Fatty Acids | EU

Omega-3 ALA 4800 mg

With more than 600 mg of omega-3 ALA per serving

Cholesterol 0mg

0%

Sodium 248mg

11%

Total Carbohydrates 55.5g

20%

HEALTH CLAIMS*

Dietary Fiber 2g

7%

Alpha-linolenic acid | USA

Total Sugars 9.3g Protein 14g

Neurological protection

28%

* The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2000 calories a day is used for general nutrition advice.

RECOMMENDED INTAKE

•

ALA omega-3s promote cardiovascular health

•

ALA omega-3s may support immune health

Alpha-linolenic acid | EU ALA contributes to the maintenance of normal blood cholesterol levels.

Four tablespoons (50 g) prepared with 200ml of milk, water, or any nutritional formula up to twice daily.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science IN SUMMARY: In summary: Adequate or supplementary ALA omega-3s may offer protection for older adults against cognitive declines and neurologic conditions like stroke.

THE EVIDENCE: ALA OMEGA-3S AND

THE EVIDENCE: ALA VS. DHA

COGNITIVE DECLINE

When it comes to getting our fill of omega-3s, ALA alone

•

Dietary intake of omega-3 fatty acids during older

may be able to get the job done. Experts have long

adulthood may reduce the risk of all-cause dementia

believed that DHA and EPA are the "hero" sources of

or cognitive decline by 20%.

omega-3 fatty acids, since ALA was thought to have a

•

4

ALA supplementation during midlife, years before

poor rate of conversion to DHA. However, methods of

the onset of Alzheimer's disease (AD) symptoms may

measuring rates of ALA conversion have advanced. Using

help prevent or ameliorate slowed brain glucose

novel tracking strategies, scientists are now learning that

metabolism, which contributes to the development

DHA is stored in the body's tissues long-term, and only a

of AD.5

small fraction of those reserves actually need to be topped

THE EVIDENCE: ALA OMEGA-3S AND NEUROLOGIC PROTECTION •

ALA supplementation supports brain health and increases antioxidant activity by increasing levels of

off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.9,10,11

brain-derived neurotrophic factors (BDNF), which promotes the growth of new nerve cells in the brain.6 •

Low levels of BDNF may increase stroke risk and inhibit stroke recovery, while targeting BDNF levels may support stroke recovery7, suggesting that ALA may support recovery from neurologic conditions like stroke.8

REFERENCES Scan the QR code to access scientific references and claim validations.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

23

References 1.

Pais R, Ruano L, P Carvalho O, Barros H. Global Cognitive Impairment Prevalence and Incidence in Community Dwelling Older Adults-A Systematic Review. Geriatrics (Basel). 2020 Oct 27;5(4):84. doi: 10.3390/ geriatrics5040084. PMID: 33121002; PMCID: PMC7709591.

7.

Liu W, Wang X, O'Connor M, Wang G, Han F. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities. Neural Plast.

2020 Jan 27;2020:1969482. doi: 10.1155/2020/1969482. PMID: 32399020; PMCID: PMC7204205.

2.

ADI - Dementia statistics. (n.d.). https://www.alzint.org/about/dementiafacts-figures/dementia-statistics/

8.

3.

Fekete M, Lehoczki A, Tarantini S, Fazekas-Pongor V, Csípő T, Csizmadia Z, Varga JT. Improving Cognitive Function with Nutritional Supplements in Aging: A Comprehensive Narrative Review of Clinical Studies Investigating the Effects of Vitamins, Minerals, Antioxidants, and Other Dietary Supplements. Nutrients.

2023 Dec 15;15(24):5116. doi: 10.3390/nu15245116. PMID: 38140375; PMCID: PMC10746024.

Hadjighassem, M., Kamalidehghan, B., Shekarriz, N. et al. Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans. Nutr J 14, 20 (2015). https://doi.org/10.1186/s12937-015-0012-5

9.

Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research [Internet] 2015 Jul [cited February 13, 2025];59:54-66. doi: 10.1016/j.plipres.2015.04.002. Epub 2015 Apr 25. PMID: 25920364.

4.

Wei BZ, Li L, Dong CW, Tan CC; Alzheimer’s Disease Neuroimaging Initiative; Xu W. The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers. Am J Clin Nutr. 2023 Jun;117(6):1096-1109. doi: 10.1016/j.ajcnut.2023.04.001. Epub 2023 Apr 5. PMID: 37028557; PMCID: PMC10447496.

10.

Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res. 2001 Apr;42(4):581-6. PMID: 11290830.

11.

Domenichiello AF, Kitson AP, Chen CT, Trépanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem. 2016 Apr;30:167-76. doi: 10.1016/j.jnutbio.2015.11.016.

Epub 2015 Dec 12. PMID: 27012633.

5.

Lázaro I, Grau-Rivera O, Suárez-Calvet M, Fauria K, Minguillón C, Shekari M, Falcón C, García-Prat M, Huguet J, Molinuevo JL, Gispert JD, Sala-Vila A; ALFA study. Omega-3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia. Alzheimers Dement (Amst).

2024 Jul 5;16(3):e12596. doi: 10.1002/dad2.12596. PMID: 38974876; PMCID: PMC11224768.

6.

Hadjighassem, M., Kamalidehghan, B., Shekarriz, N. et al. Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans. Nutr J 14, 20 (2015). https://doi.org/10.1186/s12937-015-0012-5

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

25

Application Concept in Dietary Supplements/Functional Foods CHIA FIBER AND XYLOGLUCANS FOR IRRITABLE BOWEL SYNDROME

INGREDIENTS CHIA FIBER + XYLOGLUCANS CAPSULES

Xia Powder 435 W LM (chia fiber), High purity

The combination of Xyloglucans and Chia fiber significantly

Xyloglucan (tamarind).

improved stool consistency, IBS symptoms (abdominal

COMPOSITION/NUTRITION FACTS

pain, bloating, discomfort), and quality of life. Additionally, Xyloglucans and Chia Fiber treatment restored serum

Per sachet (10g):

zonulin concentrations to within normal ranges,

Chia Fiber

Xyloglucans

10 g

100 mg

suggesting an improvement in intestinal barrier function.

RECOMMENDED FOR Adults with Irritable Bowel Syndrome or constipation RECOMMENDED INTAKE One sachet up to twice per day

Irritable bowel syndrome (IBS) is a functional bowel disorder classified among the Disorders of Gut–Brain Interaction (DGBI)1

SUGGESTED FORMAT 10g sachet/stick NUTRIENT CONTENT CLAIMS* •

Good Source of Omega-3 /EU

•

High in Omega-3 Fatty Acids /USA

IBS affects approximately 4–10% of the

•

High in Fiber /USA /EU

global population. 2 A subset of IBS, IBS

FUNCTION/ STRUCTURE CLAIMS*

with constipation (IBS-C), accounts for

•

Digestive Regularity5

•

Prebiotic Effect6

•

Glucose Management4

•

Appetite Control3

•

Cholesterol support4

about 30% of IBS cases.

KEY ADVANTAGES •

Chia fiber contains: - up to 56% of total fiber, including both soluble and insoluble types - Alpha-linoleic acid (ALA, an essential omega-3 fatty acid)

•

100% natural with no additives

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Claims are subject to local regulation

The Science IN SUMMARY: The combination of Xyloglucans and Chia fiber significantly improved stool consistency, IBS symptoms (abdominal pain, bloating, discomfort), and quality of life compared to the placebo. Additionally, Xyloglucans and Chia Fiber treatment restored serum zonulin concentrations to within normal ranges, suggesting an improvement in intestinal barrier function.7

THE EVIDENCE: CHIA FIBER AND XYLOGLUCANS

The study also found a weak correlation between serum

A recent study demonstrated that Xyloglucans and Chia

zonulin concentration and IBS symptoms (specifically

Fiber significantly improves abdominal pain, bloating,

constipation), supporting the growing evidence that

discomfort, and stool consistency in patients with IBS-C.

barrier dysfunction plays a role in IBS-C pathophysiology.

It also led to a reduction in serum zonulin concentrations, suggesting a potential role in restoring intestinal barrier integrity and permeability. XP+CS was a safe therapeutic option that significantly improved the quality of life and psychological well-being of IBS-C patients.

The positive effects of Xyloglucans and Chia Fiber on stool consistency, IBS symptoms, and quality of life were observed as early as 15 days from treatment onset.

This is particularly relevant given that many existing treatments for IBS-C are ineffective in managing all

This study provides clinical evidence for the gastrointestinal effects of chia fiber in combination with xyloglucan. This therapy is safe, well-tolerated, and effective in controlling constipation, abdominal pain, and bloating in IBS-C patients, significantly improving their quality of life.

symptoms and improving quality of life. Unlike some laxatives or certain fibers that can cause side effects or worsen symptoms, Xyloglucans and Chia Fiber normalized stool consistency without causing diarrhea or other adverse effects.

REFERENCES Scan the QR code to access scientific references and claim validations.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

27

References 1.

Mearin, F.; Lacy, B.E.; Chang, L.; Chey, W.D.; Lembo, A.J.; Simren, M.; Spiller, R. Bowel Disorders. Gastroenterology 2016, 150, 1393–1407.

2.

Sperber, A.D.; Bangdiwala, S.I.; Drossman, D.A.; Ghoshal, U.C.; Simren, M.; Tack, J.; Whitehead,W.E.; Dumitrascu, D.L.; Fang, X.; Fukudo, S.; et al.

Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study. Gastroenterology 2021, 160, 99–114.e3.

3.

Aylin Ayaz, Asli Akyol, Elif Inan-Eroglu, Arzu Kabasakal Cetin, Gulhan Samun and Filiz Akbiyik. Chia seed (Salvia Hispanica L.) added yogurt reduces short-term food intake and increases satiety: randomized controlled trial.

Nutrition Research and Practice 2017;11(5):412-418

4.

Alba Tamargo, Diana Martin, Joaquín Navarro del Hierro, M. Victoria Moreno-Arribas, Loreto A. Muñoz, Intake of soluble fibre from chia seed reduces bioaccessibility of lipids, cholesterol and glucose in the dynamic gastrointestinal model simgi®, Food Research International, Volume 137, 2020.

5.

Gotterland, M; Evaluation of the digestive tolerance to a high-fiber “chia flour” (Salvia hispánica L.) in asymptomatic volunteers. (2019)

6.

Alba Tamargo, Carolina Cueva, Laura Laguna, M.Victoria Moreno-Arribas, Loreto A. Muñoz, Understanding the impact of chia seed mucilage on human gut microbiota by using the dynamic gastrointestinal model simgi®, Journal of Functional Foods, Volume 50, 2018, pages 104-111.

7.

Armova, M.; Nikolova, M.S.; Draganov, P.M.; Peneva, P.V.; Sabaté, J.M.; Santos, J. Efficacy and Safety of Chia Seed Powder, Pea Protein, and Xyloglucan in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.

Gastrointest. Disord. 2025, 7, 19.

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

29

Application Concepts in Dietary Supplements Benexia's virgin, cold-pressed Xia Oil is the highest 100% natural plant-based source of omega-3 with 63% ALA. With an exceptional range of bioactive compounds that potentiate and amplify omega-3 physiological effects, its series of polyphenols, tocopherols and plant sterols are characterized by having an adjuvant role in anti-inflammatory processes, which in combination with ALA, bring remarkable health benefits when consumed while providing an outstandingly high Oxygen Radical Absorbance Capacity (ORAC) and an excellent Oxidative Stability. Also, it has a light, clean flavor, making it the ideal omega-3 profile enrichment.

Potential Product Blends & Concepts FISH EPA/DHA + CHIA OIL ALA EPA + DHA + ALA: Enhanced Absorption of Essential Omega-3s

POSSIBLE CONCEPTS/POSITIONINGS FISH OIL PLUS SINGLE STRENGTH “PLUS” DOUBLE STRENGTH OMEGA-3 PLUS ALA + DHA STRENGTH CHIA PLUS

Virgin plant-based chia oil blend > 60% Essential ALA + high-quality fish oil

TRIPLE STRENGTH OMEGA-3 PLUS CARDIOVASCULAR BOOSTER

STRUCTURE/FUNCTION CLAIMS* | USA

A more sustainable omega-3 offer

ALA-DHA Scientific evidence demonstrates that diets that includes omega-3 fatty acids (DHA and ALA) may: • Strengthens heart health for cardiovascular support.

• Supports immune system.

Boost competitiveness and long-term

• Improves brain development during pregnancy

stable prices

and lactation.

• Promotes healthy skin, hair and nails.

New Solutions for Real Opportunities FISH EPA/DHA + CHIA OIL ALA BLENDS & FORMULATIONS

POSITIONING

STRATEGY

ALA + EPA DHA 1812 • High Volume / Rotation High ALA Chia Oil (70-80%) + Low EPA DHA

• FISH OIL PLUS

• Competitive cost

1812 (30-20%)

• REFINED FISH OIL "PLUS"

• Supply predictability • Price stability

ALA + EPA DHA 3020 ALA Chia Oil + EPA DHA 3020 (50%-50%)

• FISH OIL PLUS • DOUBLE STRENGTH OMEGA-3 PLUS • ALA EPA DHA STRENGTH

• Optimized PUFAs composition • Nutritionally balanced

• ALA EPA DHA STRENGTH

• Volume

High ALA Chia Oil + EPA DHA 3020

• FISH OIL PLUS

• Supply predictability

(75%-25%)

• STRENGTH

• Price stability

• CHIA PLUS

• Enhanced PUFAs profile

ALA + EPA DHA 5020

High ALA Chia Oil + EPA DHA 5020 (65%-35%)

• Triple strength OMEGAs

• FISH OIL PLUS

• Supply predictability

• TRIPLE STRENGTH OMEGA-3 • PLUS CARDIOVASCULAR BOOSTER

KEY ADVANTAGES

• Price stability • Highly concentrated

TARGET

• Complete omega-3 fatty acid profile increasing nutritional and functional value

• Maternity • Brain and vision health

• Generate EPA & DHA biosynthesis by ALA + DHA supplementation

• Cardio - cholesterol

• Allergen-free ingredients

• Balanced nutrition

• No fishy flavor or reflux • Low saturated fats • Improved oxidative stability and organoleptic properties • 3 Health claims: ALA and Cholesterol, EPA DHA and Brain and Vision • MOSH / MOAH EU limit compliant • Environmentally conscious • Very cost-effective • More stable and predictable price and supply

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

31

Dietary Supplements: Chia Oil Soft Gel Caps Potential Product Blends & Concepts ALGAE DHA + CHIA OIL ALA ALA + DHA, fully plant-based Omega-3s: A full PUFAs offer20,25

POSSIBLE CONCEPTS/POSITIONINGS ALGAE CHIA PLUS

STRUCTURE/FUNCTION CLAIMS* | USA ALA-DHA Scientific evidence demonstrates that diets that includes

ALA + MARINE DHA

omega-3 fatty acids (DHA and ALA) may:

FULL VEGAN OMEGAs

• Strengthens heart health for cardiovascular support.

OPTIMIZED PUFAs FULL ANTIOX LIPIDS POTENCY EFAs METABOLISM BOOSTER

• Supports immune system.

• Improves brain development during pregnancy and lactation.

• Promotes healthy skin, hair and nails.

HEALTH CLAIMS | EU Omega-3 ALA Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels.

Recommended daily intake: 2g ALA. Omega-3 DHA Docosahexaenoic acid (DHA) maternal intake contributes

Virgin plant-based chia oil blend

to the normal brain development and normal development

> 60% Essential ALA + refined algal oil

of the eye of the foetus and breastfed infants. The beneficial effect for pregnant and breastfeeding women is obtained with a daily intake of 200mg of DHA in addition to the recommended daily intake for omega-3 fatty acids for adults (250mg DHA and EPA).

A fully sustainable omega-3 offer from plants

Competitive and predictable prices

New Solutions for Real Opportunities ALGAE DHA + CHIA OIL ALA BLENDS & FORMULATIONS

POSITIONING

STRATEGY

ALA + DHA 400

High ALA Chia Oil (70%)

• MARINE + PLANT-BASED OMEGAS PLUS

Low DHA (30%)

• ALA + MARINE DHA

• Full plant-omega3 reserves • Enhanced DHA metabolism • Full supply predictability

• EFAs METABOLISM BOOSTER

• Price stability • Sustainability

ALA + EPA/DHA 100 500 • ONLY FULL PLANT-BASED OMEGAS High ALA Chia Oil (65%)

• FULY OPTIMIZED

• Optimized PUFAs composition

Low EPA/DHA (35%)

• ALA/EPA/DHA Profile

• Nutritionally balanced

• EFAs METABOLISM BOOSTER ALA + EPA

High ALA Chia Oil (60 to 80%) Low EPA (20 to 40%)

• EFAs METABOLISM BOOSTER • ANTIOX LIPIDS FULL POTENCY • FULL VEGAN TRIPLE STRENGTH

KEY ADVANTAGES

• Optimized viscosity for capsule filling • Complete pack of bioactive compounds • Supply predictability • Price reduction

TARGET

• Generate EPA biosynthesis by ALA + DHA supplementation

• Maternity

• Allergen-free ingredients

• Brain and vision health

• No fishy flavor or reflux

• Cardio - cholesterol

• 100% Plant-based

• Balanced nutrition

• Low saturated fats • Improved oxidative stability • 3 Health claims: ALA and Cholesterol, EPA/DHA and Brain and Vision • MOSH / MOAH EU limit compliant • Environmentally conscious • Very cost-effective • More stable and predictable price and supply • Optimized viscosity for capsule filling

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

33

Dietary Supplements: Chia Oil Soft Gel Caps 100% CHIA OIL 100% Plant-based ALA: Omega-3 metabolism booster20,22

PRODUCT POSITIONING CHIA PLUS

KEY ADVANTAGES • 100% vegetal • 63% of plant-based omega-3

ENHANCE YOUR OMEGAs-3

• Omega-3 Metabolism Booster

FULL PLANT-BASED OMEGAS

• Generate EPA and DHA biosynthesis by ALA

BIOACTIVE CHIA POWER CHIA ACTIVE POWER ANTIOXIDANT CHIA POWER STRUCTURE/FUNCTION CLAIMS* | USA

supplementation • Allergen-free ingredients • No fishy flavor or reflux • 100% plant-based • Low saturated fats • Improved oxidative stability • Health claims: ALA and cholesterol

• Support heart and cardiovascular health.

• MOSH / MOAH EU limit compliant

• Reduce inflammation.

• Environmentally conscious

• Supports immune system.

• Very cost-effective • Fully predictable price and supply

HEALTH CLAIMS | EU Omega-3 ALA Alpha-linolenic acid (ALA) contributes to the maintenance

• High in antioxidants, polyphenols, tocopherols and phytosterols.

of normal blood cholesterol levels.

TARGET

Recommended daily intake: 2g ALA.

• Cardio - cholesterol • Cardio - hypertension/circulation • Balanced nutrition

Virgin plant-based chia oil > 60% Essential ALA

A fully sustainable omega-3 offer from plants

Competitive omega-3 alternative

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Application Concept in Dietary Supplements ACTIVE INGREDIENTS SUPPLEMENTS NUTRITIONAL BOOSTER Benexia® Xia Oil is made from our cold-pressed premium chia seeds (Salvia hispanica) through a proprietary extraction process that carefully preserves chia oil's essential fatty acids and bioactive compounds. Chia oil is the richest source of Alpha-linolenic acid omega-3 (63% ALA) and contains important bioactive substances: tocopherols, polyphenols, and phytosterols.

Benexia® Xia Oil also acts as a carrier for liposoluble compounds, boosting their intestinal absorption and enhancing each compound's functionality and efficacy.

CONCEPTS CHIA OIL + ACTIVE LIPOSOLUBLE COMPOUNDS The highest plant-based source of alpha-linolenic acid with liposoluble vitamins (K2, retinol, D2/D3, E) and bioactive compounds for effective absorption, inflammation resolution, antioxidant, and immune protection.

KEY ADVANTAGES •

100% vegetal and sustainable sources of omega-3.

•

Lipid delivery system for better absorption

•

Non-GMO

•

Essential nutrients for healthy body

RECOMMENDED DAILY DOSE 2 capsules per day

1000 mg softgel oblong capsules

Enhanced functionality and efficacy of liposoluble compounds

Formulation Concepts For Active Ingredients Supplements INGREDIENTS

ACTIVE COMPOUNDS

STRUCTURE/ FUNCTION CLAIMS* USA

HEALTH CLAIMS EU

TARGET

INMUNITY CHIA OIL + VITAMIN D3

Per 2 Capsules • Benexia® Chia Oil: 2000 mg • Vitamin D3: 50 mcg

Alpha-Linolenic (ALA) Acid Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

Alpha-Linolenic (ALA) Acid • Improves heart and cardiovascular health.

• Supports immune system.

• Promotes healthy skin, hair and nails.

• Immune system.

• Cardio - cholesterol.

• Balanced nutrition.

Vitamin D • Contributes maintenance of normal bones and teeth.

• Normal muscle function.

• A normal function of the immune system.

Vitamin D • Essential for bone health.

• Provides immune support.

• Promotes healthy muscle function.

VISION CHIA OIL + VITAMIN A, ASTAXANTIN AND LUTEIN

Per 2 Capsules • Alpha-Linolenic (ALA): 1070 mg • Lutein: 20 mg • Astaxanthin: 4 mg

Alpha-Linolenic (ALA) Acid • Improves heart and cardiovascular health.

• Supports immune system.

• Promotes healthy skin, hair and nails.

Alpha-Linolenic (ALA) Acid Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

• Brain and vision health.

• Antioxidant protection.

• Senior.

Alpha-Linolenic (ALA) Acid Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

• Antioxidant protection.

• Hair, skin and nails.

• Cardio - cholesterol.

Astaxantin • Provides antioxidant protection.

• Naturally supports eye, joint and heart health.

Lutein • Supports visual function and macular health.

BEAUTY SKIN CHIA OIL + CO-ENZYME Q10

Per 4 Capsules • Alpha-Linolenic (ALA): 1700 mg • Q10: 100 mg

Alpha-Linolenic (ALA) Acid • Promotes healthy skin, hair and nails.

• Supports the immune system.

Co-enzyme Q10 • Powerful antioxidant and anti-aging.

• Protects cells from damage.

• Helps support heart function.

• Increases energy production.

* Claims are subject to local regulation. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Chia Oil as a Food Dietary Supplement:

Simply add it to your food; it has a great taste!

Natural, plant-based

Essential for your health

Your daily Omega-3

63%

omega-3 ALA

Leet your food be your medicine Take a spoon per day

Light and delicate nutty taste

Ideal for enhancing meals, smoothies, beverages, or soups.

Sustainable food from regenerative agriculture

XIA OIL SCIENCE-BASED APPLICATION CONCEPTS

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Benexia®, a leader in the industry Launched in 2000, Benexia® is a world leader in the production, processing, and commercialization of chia and chia-based ingredients. Our company is vertically integrated from agricultural production to final ingredients and solutions, including plant cultivation, extraction, concentration processes, and ingredients development.

We guarantee traceability from the fields and certified quality (GAP, GMP-HACCP, and FSSC 22000). Benexia products are certified Halal and Kosher.

Sustainability and Corporate Responsibility Benexia employs regenerative agriculture to achieve lower carbon and water footprints from planting to harvesting. These practices are incorporated by the brand's farming partners in Bolivia, Argentina, and Paraguay. Harvested chia seeds are processed without the use of gas or water. Seeds are cleaned and separated using physical processes such as airflow and density-based separation methods, yielding a final seed product that's 99.95% pure.

Since its founding in 2005, Benexia is dedicated to supporting the welfare of its local communities. Benexia is aligned with the United Nations' Sustainability Development Goals and is on track to complete its B Corp certification by 2025. Half of Benexia's partner shareholders are chia farmers. This guarantees fair pricing and technical support within the company's supply chain as well as full traceability of ingredients.

Our team, the best customer service We're passionate about health, wellbeing, and providing exceptional service for our customers. We offer support in formulation, nutrition, scientific and regulatory matters, with the best experts to assist your needs.

Contact us for samples, application sheets and more information at info@benexia.com

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Luis Pasteur 5850, Of. 403, Vitacura, Santiago - Chile |

Tel: + (56 2) 2437 5820 | info@benexia.com |

www.benexia.com