Xia Oil, a New Sustainable Source of Omega-3 ALA by Benexia

An Ancient Superfood for the 21st Century

The Power of Chia

The seeds of change may start small, but in the right environment, they grow mighty. That can certainly be said of the chia plant, whose minuscule seed grains nourished ancient civilizations for centuries - and has, in recent decades, experienced a revitalization as a superfood ideal for meeting the needs of modern consumers.

Most call Chia a seed, though it’s technically a grain. Regardless of how consumers categorize it, the tiny black or white orbs far surpass their seed or grain counterparts when it comes to nutrition: Chia brings together protein, omega-3 fatty acids, fiber, antioxidants, and an array of minerals, all in a package no bigger than a pinhead.

An ancient food with the highest omega-3 content found in nature: with unsuspected health benefits, chia is an amazing sustainable source of essential nutrients.

A unique nutritional profile has enabled for chia to sustain civilizations such as the Aztecs and the Mayans. Today, a mounting body of evidence shows that the grain has the potential to aid in addressing some of our most pressing health concerns, including heart disease, diabetes, inflammation, and neurocognitive and neurodegenerative conditions. Chia’s nutritional components have also proven integral to fetal and child development, positioning it to support the health of coming generations through pre- and postnatal nutrition.

The versatile grains can be enjoyed whole (both raw or soaked) or cold-pressed into a nutrient-dense oil, while the leftover matter can be ground in a fiber- and protein-rich flour.

The fact that chia is plant-based, free of gluten, zero net carbs, and high in protein has also made it popular among multiple dietary patterns, including vegan, lowcarb/keto, and gluten-free diets.

40% of Dietary Fiber 22% of Proteins 20% of Omega-3 6% of Omega-6 1:4 omega-6:omega-3 ratio

Minerals

Calcium, phosphorus, magnesium, potassium Vitamins

High levels of antioxidants, tocopherols, and plant sterols

A Highly Sustainable Food Source

Chia, too, is a food that supports the health of the planet. Requiring few resources to thrive in its native environment, the crop supports humanity’s need for increased sustainability, reduced water usage, and fewer greenhouse gas emissions in our global food supply.

Chia is, by its very nature, a highly sustainable crop. Grown in its native South America, where it evolved to thrive—it’s the right plant for the right place—and can be grown with minimal additional resources. Benexia, a fully integrated company specializing in the production, processing, and commercialization of chia and chia-based ingredients, has built on these inherent qualities to yield an eco-friendly farming production process that gives back to the local environment, local communities, and the planet at large. Ultimately, chia is a food people can feel good about.

99.95%

the level of purity of chia seeds grown, cleaned and processed by Benexia

After a couple of years of carefully monitored harvests, chia fields are left to rest crop-free for 1-2 years during which grasses are planted and animals can graze. Once the land has been fully replenished and the soil’s inherent nutrient composition is again optimal, a new crop is planted. These crop rotation practices support healthier soil, which in turn yields greater crop resilience as well as more reliable local economic activity.

Chia’s nutrition, sustainability, and versatility make it a highly appealing option for consumers and food manufacturers.

CLEAN, NO-WASTE PRODUCTION METHODS

Fresh from the field, Benexia's newly-harvested chia seeds are processed in highly sustainable ways. Seeds are cleaned and separated using physical processes such as airflow and density-based separation methods, yielding a final seed product that's 99.95% pure.

From there, all parts of the seeds are used to ensure that nothing is lost - and no resources are wasted. After the seeds are cleaned, they are pasteurized with a specialized, organically certified process that uses no solvents, chemicals, or water, while the omega-3 rich chia oil is extracted from the seeds via a single cold pressing to retain maximum nutrition capacity. The oil is cleaned and purified through a filter, that, again, requires no chemicals or solvents.

Once the oil is extracted from the seeds, the leftover fibrous matter is dried and milled to separate the fiber from the protein. The powdered chia fiber and protein, now a fine flour, can be incorporated into baked goods, pizza crusts, breads, and more, as a source of zero-waste, functional nutrition.

CORPORATE RESPONSIBILITY

Considering Benexia's commitment to the planet, it may come as no surprise that, since its founding in 2005, the company is equally dedicated to supporting the welfare of its local communities. Benexia is aligned with the United Nations’ Sustainable Development goals and is on track to complete its B Corporation certification by 2024.

As a vertically integrated company, 50% of Benexia's partner shareholders are chia seed farmers. This guarantees fair pricing and technical support within the company's supply chain as well as full traceability of their ingredients.

Benexia® Xia Oil

Natural and Virgin, with >60% of Essential Omega-3

Cold-pressed from fresh, high-quality, low-moisture chia seeds, chia oil is a pure, extra virgin, unrefined oil made without chemical solvents or diluents. Benexia's careful processing preserves chia's liposoluble nutrients and bioactive components, resulting in an oil with the highest concentration of essential omega-3 fatty acids among plant-based oils, with an excellent oxidative stablility and superior organoleptic properties.

FATTY ACIDS PROFILE

SATURATED: 10.5%

With 63% of chia oil’s total fat consisting of omega-3 ALA, just one teaspoon provides twice the recommended daily ALA intake, qualifying as an “excellent source.”

7.2%

C22:6n3 Docosahexaenoic

Discovering Chia Oil´s Hidden Power: A nutritionally Essential

Precursor Oil

When considering the nutritional benefits of chia oil, it is not solely about omega-3 fatty acids. What makes chia oil a one-of-a-kind seed oil is its diverse range of bioactive compounds that are concentrated inside.

With the power to potentiate and amplify omega-3 physiological effects, this series of polyphenols, tocopherols and plant sterols are characterized by having an adjuvant role in anti-inflammatory processes, which, combined with ALA, bring remarkable health benefits.

CHIA’S BIOACTIVE COMPOUNDS

• Activate anti-inflammatory activity and simultaneously suppress the production of proinflammatory substances.

• Are tied to decreases in reactive oxygen species and reducing inflammatory processes that may slow or thwart the development of disease.

• They modify the mechanisms related to endothelial dysfunction, platelet aggregation, and atherosclerosis.

• They inhibit the activity of cyclooxygenase (responsible for the production of prostaglandins) and decrease the synthesis of inflammatory cytokines and the activity of the parasympathetic nervous system.

• These actions help reduce the risk of cardiovascular events and hypertension, among other conditions.

This way, chia oil counteracts the detrimental factors involved in the development of the most prevalent health conditions nowadays, exhibiting a remarkable protective effect.

In addition, these bioactive compounds contribute to Benexia Chia Oil’s outstandingly high Oxygen Radical Absorbance Capacity (ORAC) and excellent Oxidative Stability.

The latest scientific studies on lipid metabolism are re-considering the role of ALA in nutrition and health and offering a wide field of applications in lipid combinations for nutraceutical solutions. These combinations can help brands and consumers to expand and re-think their offer with more complete omega-3 profiles and functionalities.

Chia oil is natural and extra virgin; therefore, it is free of MOAH. Also, its content in MOSH is very under the regulatory limits.

** MOSH stands for Mineral Oil-Saturated Hydrocarbons, which are a health concern. They are paraffin-like, open-chained, commonly branched hydrocarbons (e.g., alkanes) and naphthene-like cyclic hydrocarbons (cycloalkanes). MOSH accumulates in the liver and lymphoid system, causing inflammation. MOSH/POSH (sum) <5 mg/kg. The most likely cause of its presence in chia oil and the oils industry is transfer through the packaging material.

* MOAH stands for Mineral Oil Aromatic Hydrocarbons.

BIOACTIVE COMPOUNDS:

ANTIOXIDANTS

Health Benefits

Caffeic acid and Coumaric acid showed a positive effect on reducing carcinogenic incidence. It is known to have antimitogenic, anticarcinogenic, anti-inflammatory and immunomodulatory properties.

Health Benefits

Emerging data reveal that gamma tocopherol supplies potent protection against cardiovascular disease, cancer, and even neurodegenerative conditions. Gamma tocopherol has superior anti-inflammatory and gene regulatory activities, while alpha-tocopherol remains a potent antioxidant.

Health Benefits

Numerous clinical trials have demonstrated that daily consumption of foods enriched with plant sterols or stanols lowers serum LDL cholesterol. In addition to the cholesterol-lowering and anti-cancer properties of phytosterols, there is also evidence that these components have antioxidant activity.

ORAC

>2500 μmol/TE

82.2% Polyunsaturated

63% Omega-3 ALA

19% Omega-6 LA

10,5% Saturated

7,2% Monounsaturated 7% Omega-9 Oleic

Omega-3 to Omega-6 ratio in Benexia Chia Oil: balance your Omega’s

Chronic inflammation has shown to be a risk factor for major health conditions, including heart disease, diabetes, and many others. The typical Western diet is too high in pro-infammatory foods, among them omega-6 fat sources like vegetable oils including soybean, sunflower, palm,

Grapeseed oil

Avocado oil

Refined soybean oil

Sesame oil

Refined high-oleic sunflower oil

Refined canola oil

Peanut oil

Refined corn oil

Palm oil

Cottonseed oil

CHIA OIL - COLD-PRESSED

Refined Sunflower oil

Extra virgin olive oil

Walnut oil

Macadamia nut oil

Almond oil

Coconut oil

Ghee (Clarified Butter)

Lard

Butter

Virgin olive oil

Flaxseed oil

and canola. Omega-3 fats, like those found in chia oil, are anti-infammatory in nature. Increasing them in the diet can help establish a healthier omega-6 to omega-3 ratio overall, creating a better balance to promote health1 .

Chia Oil is the most effective way to rebalance the omega-3 to omega-6 ratio in the body

Scientific Evidence

Chia Oil and Health: What The Science Says

PRENATAL, PEDIATRIC, AND MATERNAL HEALTH

As an essential precursor to DHA, ALA omega-3 intake can drive up levels of DHA and EPA.

HUMAN STUDY: CHIA OIL SUPPLEMENTATION IN PREGNANT WOMEN

In 2015, a study of 40 young and healthy pregnant women, age 22 -35 years, received from the third trimester of pregnancy until the first six months of nursing, either 12 g of chia oil daily for 9 months or placebo. The results of this study show that chia oil consumption during pregnancy and breastfeeding increases the content of ALA (76%) and EPA (57%) in erythrocyte phospholipids and the content of ALA (60%) and DHA (50%) in breast milk. 5

Before Xia Oil supplementation (start of supplementation at 6th month of pregnancy)

After 3 months of 12 g Xia Oil supplementation daily (delivery)

After 9 months of 12 g Xia Oil supplementation daily (6 months nursing)

Fatty acid composition of erythrocyte phospholipids of mothers during pregnancy and nursing after 9 months of supplementation of 12 g of Chia Oil daily.

Pregnant and breastfeeding women are recommended to consume both DHA and ALA omega-3s for their baby's brain and eye development. 2,3,4

NEUROLOGICAL BENEFITS

A recent trial found that women who take 5 g of omega-3s daily at the end of pregnancy and at the onset of

breastfeeding have a greater chance of alleviating some of the symptoms related to postpartum depression.6,7

ANTI-INFLAMMATORY BENEFITS FOR CHRONIC DISEASE PREVENTION

As plant-based omega-3 fatty acids will be naturally and efficiently biosynthesized and accumulated as circulating supplies of EPA/DHA.

Then, Chia oil's anti-inflammatory effect is related to its pro-resolutive action on the inflammatory response via SPMs, derivated from the conversion of ALA to longer-chain fatty acids, EPA and DHA. Indeed EPA/DHA are the precursors of specialized pro-resolving lipid mediators (SPMs), such as resolvin, protectin, and maresin families, which have been considered therapeutic bioactive compounds for human health. In addition, chia oil itselft has important levels of bioactive compounds: phenolic acids, tocopherols and tocotrienols.

Growing evidence indicates that SPMs are beneficial strategies in ameliorating, regulating, and promoting the resolution of inflammatory processes through different biological actions. 8,9

CARDIOVASCULAR HEALTH

In addition to its role in producing EPA and DHA, omega-3 ALA has independent and specific effects on health.

Consumption of dietary ALA has been shown to have a significant association with reduced risk factors for cardiovascular disease and decreased mortality risk from cardiovascular and coronary heart diseases:

A higher intake of ALA reduces the risk of ischemic heart disease (also called coronary heart disease) and is significantly associated with a lower risk of CVD and CHD mortality.10

Evidence suggests that ALA intake reduces the risk of ventricular arrhythmia by more than 25%.11,12

ALA supplementation has been shown to help lower total cholesterol, LDL cholesterol, and triglycerides, and increase HDL cholesterol.14

Beneficial effects in the prevention and management of:

• Diabetes and metabolic disorders

• Heart disease

• High blood pressure

• Neuropsychiatric and neurodegenerative diseases

• Obesity

• Arthritis and joint pain

• Skin-related conditions like psoriasis

Several investigations have shown the beneficial effects of ALA administered alone or as a component of food in lowering blood pressure.10,12,15,16

Epidemiological evidence has shown that higher dietary ALA is associated with lower inflammation, as measured by inflammatory biomarkers.15,16

Higher ALA intake has been shown to be associated with decreased intima-media thickness (IMT), inferior carotid plaque, and coronary artery plaque.10,12,15

A New Perspective on ALA Metabolism and Conversion to Long-Chain Omega-3 EFAs

NEW SCIENCE: GLOSSARY OF NEW CONCEPTS

Polyunsaturated Fatty Acid (PUFAs) Biosynthesis Pathway: The metabolic pathway responsible for converting ALA into EPA/DHA and LA into AA, involving desaturation and elongation steps.

The Basics of PUFA s Metabolic Pathway

ß-Oxidation

Cell membranes

Desa turases Elongases

Desa turases Elongases Desa turases Elongases

Cyclooxygenases (COX) Lipooxygenases

Cyclooxygenases (COX) Lipooxygenases D-Resolvins

PRO-RESOLUTIVE

PRO-INFLAMMATORY

In mammals, except for felines, ALA is efficiently absorbed at the intestinal level (over 96%), where after passing through the intestinal cells, it has three possible metabolic routes: (i) storage, mainly in adipose tissue, with greater storage in women than in men 47, (ii) hepatic β-oxidation18 and (iii) conversion to EPA and DHA (mainly hepatic, and to a lesser extent, neuronal).19

Compound-Specific Isotope Analysis (CSIA): A cuttingedge technique that measures the natural abundance of stable isotopes in individual fatty acids. This allows researchers to track the metabolic pathways of omega-3s with great precision, revealing their conversion rate and utilization in the body.

The Gas-Chromatography Combustion Isotope Ratio

Mass Spectrometry (GC-cIRMS) is the specific CSIA method used to measure the isotopic composition of fatty acids.

Tracer: A substance used to track the movement or metabolism of a compound of interest within a biological system. In CSIA, stable isotopes act as tracers.

Turnover refers to the dynamic process by which DHA is consumed, renewed, or replaced in the body. It encompasses both the synthesis and metabolic consumption of DHA, ensuring the body has an adequate supply for its needs.

Steady-state refers to a dynamic equilibrium in which the levels of DHA in the body are maintained relatively constant. This steady state is achieved by balancing the synthesis of DHA from precursors like ALA and EPA and its consumption or turnover in tissues.

Flux: It refers to the dynamic flow of DHA within the body. This encompasses its synthesis from precursors like ALA and EPA, its distribution to various tissues, and its utilization and turnover. DHA flux is actively regulated to meet the body's metabolic demands and maintain a steady state of DHA levels.

Half-life: The time it takes for the concentration of a substance, like DHA, to decrease by half in the body. This is a measure of how quickly the substance is eliminated or metabolized. For example, DHA’s half-life in the brain is 912 days aprox.

Tissue-dependent: It means the conversion of ALA (alphalinolenic acid) to other omega-3 fatty acids, such as EPA and DHA, differs among various tissues.

Synthesis-Secretion Rate: The rate at which the body produces and releases DHA, particularly when meeting tissue demands. The synthesis-secretion rate of DHA is closely linked to its consumption or turnover in tissues, ensuring that the body maintains a steady state of DHA despite variations in dietary intake or conversion.

Cycling ALA and EPA/DHA: supplementing strategy

discovered by Dr Bazinet that combines chronic ALA supply with periodic acute DHA or EPA DHA supplementation. This halves the need for DHA for the same biosynthesized level.

Retro-conversion: The hypothetical conversion of DHA back to EPA, which was previously believed, has been largely refuted by recent research.

β-oxidation (Beta Oxidation): A metabolic process in cells where fatty acids are broken down step-by-step to generate energy. It is highlighted as a major metabolic route for ALA in the brain, comparable to its conversion into EPA and DHA.

Metabolic Demand refers to the body's dynamic need for DHA to support essential functions, particularly in the brain. The body tightly regulates the synthesis and delivery of DHA to match its metabolic demand, ensuring that tissues receive an adequate supply even when dietary intake or conversion rates vary.

Kinetics: The study of reaction rates and the mechanisms that control them. In this case, it refers to the kinetics of ALA conversion to DHA.

Homeostasis: Maintaining a stable internal environment in the body, including regulating omega-3 fatty acid levels. This involves complex feedback mechanisms to ensure optimal function.

LA/ALA Ratio (Linoleic Acid/Alpha-linolenic Acid Ratio):

The diet’s ratio of omega-6 to omega-3 fatty acids. These fatty acids compete for enzymes in the long-chain PUFA biosynthesis pathway. Recent research suggests that the ALA content itself is a stronger determining factor for the conversion into EPA and DHA, rather than an excess of LA being historically considered detrimental to this pathway.

Lipid Mediator: Bioactive molecules derived from fatty acids, like omega-3s and omega-6s. They are important in regulating inflammation, including pro-inflammatory and anti-inflammatory actions. Omega-3s are crucial in producing specialized pro-resolving mediators (SPMs) that aid in "turning off" inflammation.

Resolution: The process of actively stopping inflammation and promoting tissue repair, often mediated by specialized pro-resolving mediators (SPMs).

SPM (Specialized Pro-resolving Mediator): Bioactive lipid mediators derived from omega-3 fatty acids that actively promote the resolution of inflammation.

What Does The New Science Say?

Our previous understanding of the EPA DHA biosynthesis pathway involved several principles, such as

• When ALA or EPA are administered, the tissue or blood levels of DHA do not appear to increase.

• When DHA is administered, retro conversion to EPA occurs, explaining the increase in EPA blood levels.

• ALA is converted to EPA but not to DHA.

A Disruptive Method

High-precision measurements on differences in natural isotope ratios in fatty acids (CSIA , compound-specific isotope analysis)17 reveal critical new evidence on Omega-3s metabolism in humans and requirements in adults

Dr Richard Bazinet from the University of Toronto (and former ISSFAL President) is a well-known and pioneer researcher on brain lipid metabolism. As such, he and his group work to improve our understanding of the EPA/ DHA endogenous biosynthesis pathway and its regulation.

Dr. Bazinet introduces the new concept of turnover and half-life, looking at Omega-3s in a new manner: how much does our body really consume of it daily, and how long does a molecule of Omega-3 live in our body before being consumed.

NEW SCIENCE: SHIFTING THE WAY TO LOOK AT OMEGA-3

OMEGA-3 INDEX: THE TRADITIONAL WAY

Total Omega-3s = Omega-3s Index %

Fatty Acids

CSIA: THE DISRUPTIVE WAY

Static Measurement "A Picture"

It measures the amount of EPA-DHA in the red blood cell membrane expressed as the percent of total fatty acids present only at that time.

Dynamic Measurement "A Tracking"

It tracks the movements of each fatty acid in the body by measuring the C-13 isotope at different stages, creating a dynamic model that shows how much was converted, used in each tissue, stored, and its precursor.

Total

Omega-3s

OMEGA-3

The novel strategies for assessing n-3 PUFA metabolism in humans with CSIA show that the stagnation in DHA levels following ALA/EPA supplementation is not caused by a low conversion rate but by a DHA tissue utilization that matches its synthesis-secretion (turnover or metabolic consumption). This means that the body adjusts the production according to its needs.17

Synthesis-secretion rates are minimally affected despite significant variations in plasma DHA pool sizes. This suggests a more significant role for the turnover of newly synthesized DHA as the primary determinant of plasma DHA levels. 22

The most significant new concept that has emerged with the latest science is the measure of the turnover or the flux of DHA the body needs. DHA synthesis from ALA matches DHA tissue consumption levels of DHA, independently of the ALA dose. 25

The human body successfully manages a dynamically changing and continually optimized endogenous flow of omega-3s from plant sources. Science suggests a low daily brain DHA requirement and the ability to retain DHA, as demonstrated by its long half-life. 26,27,28

If the brain converts 0.2–0.3% of plasma-derived ALA to DHA, not counting the approximately 1% EPA or DPA Omega-3, then an intake of 1200 mg per day of ALA in human could result in the brain itself producing 2.4–3.6 mg of DHA per day. If the various intermediaries are considered, since the brain contains very little EPA, this could be as much as 5–8 mg of DHA produced by the brain per day. This is important since the adult human brain uses only 4 mg of DHA daily approximately. 23,29,30

This synthesis-secretion rate supplies the total DHA requirement in the brain and could cover up to 50% of the DHA needs in other tissues (further studies must confirm this percentage). 20,24

The new methodology of gas-chromatography combustion isotope ratio mass spectrometry (GC-cIRMS) that Dr Richard Bazinet uses has challenged much dogma about apparently low DHA synthesis rates. 21,31 The conversion rates from ALA and EPA to DHA may be higher than previously and conventionally believed in animals and humans.

But Why haven't We Seen this Before?

BETA -OXIDATION

One of the main reasons ALA conversion has been described as low is the high percentage of ALA directed towards ß-oxidation. About 67% of ALA in the brain is directed towards ß-oxidation. 32 However, this high percentage used for ß-oxidation is not unique to ALA; other dietary-derived PUFAs are also ß-oxidized. For omega-6 fatty acids and DHA, the amounts used for ß-oxidation are around 50% and 65%, respectively. 33 We now know, thanks to new science, that the remaining percentage available for conversion into LCPUFAs is enough to cover the requirements.

MEASUREMENT LIMITATIONS

Human studies are virtually limited to blood-derived cells analysis, i.e., red blood cells, neutrophils, or plasma compartments, whose half-life is not greater than 100 days. Blood analysis does not reflect the potential elongation seen in tissue compartments such as the brain. 34,35 It measures the amount of EPA+DHA in the red blood cell membrane expressed as the percent of total fatty acids present only in that location at that time. New concepts of flux, half-life, turnover (see Glossary) are important to correctly assess the omega-3 PUFAs metabolism.

TISSUE-SELECTIVE BIOSYNTHESIS

There are significant differences in the conversion capacity between different cells, 35,36,37 indicating the selectivity and preference of tissues to biosynthesize certain ALA derivatives. 24,25

ALA-enriched diets have significantly increased ALA, EPA, and DPAn-3 in plasma, liver, and heart, and DPAn-3 and DHA in the brain. 34,38,40,42,42,43,44,45

TURNOVER LEVELS

If almost all the endogenous plasma DHA appears to be replaced by the exogenous ALA/EPA-derived DHA, it suggests that DHA levels are rigorously supported by the elongation/desaturation of metabolic precursors and that the metabolic consumption (or turnover) of DHA

derived from n-3 PUFA precursors such as ALA and EPA appear to be the main determinant of steady-state DHA levels in plasma. 39,41

GENDER DIFFERENCES

Human studies on ALA metabolism show genderdependent differences. In healthy young men, approximately 8% of dietary ALA is converted to EPA, and 0.5% to 4% is converted to DHA. 46 In healthy young women, approximately 21% of dietary ALA is converted to EPA, and 9% is converted to DHA. 47

The greater capacity to generate long-chain PUFA from ALA in young women compared to men is related to the effects of estrogen, 48,49 that may increase the activity of the desaturation/elongation pathway. 50

Revisiting some previously established principles: Important New Theories

Based on animal and human data, DHA is not retroconverted to EPA. 20,21,53 DHA inhibits elongase, which is responsible for converting EPA into DHA, and EPA blood level increases since its turnover is decreased. 51

CSIA shows EPA does convert in DHA, although DHA levels do not increase since conversion rates follow DHA metabolic demand. 53

DHA/EPA comes from ALA, and the body regulates its conversion rates following its needs. 20

When DHA is the only supplied source, high-quality ALA is needed to rescue EPA functional levels. 51,52

Regulatory Status of Chia Oil

Health, structure-function, and functional health claims

A dietary supplement having 1 gram of Xia Oil (over 600 mg of Alpha-Linolenic acid) can claim:

USA – FUNCTION STRUCTURE CLAIMS

Regulatory:

Federal Register - January 6, 2000 (page 1000 to 1050) Food and Drug Administration Final Rule under Food Labelling – 21 CFR Part 101.93

Statements Made for Dietary Supplements Concerning the Effect of the Product on the Structure or Function of the Body.

The following are examples of structure/function claims regarding ALA Omega-3 and heart health that have been reviewed and confirmed to comply with dietary supplement regulations for use on dietary supplement labels marketed in the U.S.:

• ALA Omega-3 improves heart health

• ALA Omega-3 promotes cardiovascular health

• ALA Omega-3 supports heart health

Conditions and possible restrictions of use:

Dietary supplement manufacturers, however, are required to notify the FDA of such labelling.

USA- Nutrient Content Claim:

• “Good Source of Omega-3 ALA”: 160 mg ALA per serving

• “High in Omega-3 ALA”: 320 mg ALA per serving

EUROPE –HEALTH CLAIM

Regulatory:

EFSA opinion reference 2009;7(9):1252, 2011;9(6):2203; according to Commission Regulation (EU) 432/2012 of 16/05/2012.

Authorised function health claims related to alpha-linolenic acid and maintenance of normal blood cholesterol concentrations:

“ALA contributes to the maintenance of normal blood cholesterol levels."

Conditions and possible restrictions of use:

The claim may be used only for food which is at least a source of ALA as referred to in the claim SOURCE OF OMEGA 3 FATTY ACIDS as listed in the Annex to Regulation (EC) No 1924/2006. Information shall be given to the consumer that the beneficial effect is obtained with a daily intake of 2 g of ALA.

EU- Nutrient Content Claim:

• “Good Source of Omega-3”: 300 mg ALA per 100 g/kcal

• “High in Omega-3”: 600 mg ALA per 100 g/kcal

JAPAN – FUNCTIONAL HEALTH CLAIM

Regulatory: Consumer Affairs Agency, Government of Japan.

Health function(s) Claim to be labelled on the consumer products:

“Chia seed oil contains alpha-linolenic acid. It is reported that alpha-linolenic acid is effective to lower the blood pressure of those whose blood pressure is slightly higher than normal range”.

Conditions and possible restrictions of use: The amount of functional ingredient per recommended daily intake is 2.6 grams. The Chia Oil must be manufactured by Functional Products Trading Arica S.A, Benexia ́s institutional company name.

APPLICATION CONCEPTS IN FUNCTIONAL LIPIDS

Dietary Supplements: Chia Oil Soft Gel Caps

Potential Product Blends & Concepts

FISH EPA/DHA + CHIA OIL ALA

POSSIBLE CONCEPTS/POSITIONINGS

FISH OIL PLUS SINGLE STRENGTH “PLUS”

DOUBLE STRENGTH OMEGA-3 PLUS ALA + DHA STRENGTH

CHIA PLUS

TRIPLE STRENGTH OMEGA-3 PLUS CARDIOVASCULAR BOOSTER

Virgin plant-based chia oil blend > 60% Essential ALA + high-quality fish oil

A more sustainable omega-3 offer

Boost competitiveness and long-term stable prices

STRUCTURE/FUNCTION CLAIMS* | USA

ALA-DHA

Scientific evidence demonstrates that diets that includes omega-3 fatty acids (DHA and ALA) may:

• Strengthens heart health for cardiovascular support.

• Supports immune system.

• Improves brain development during pregnancy and lactation.

• Promotes healthy skin, hair and nails.

HEALTH CLAIMS | EU

Omega-3 ALA

Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels. Recommended daily intake: 2g ALA.

Omega-3 DHA

Docosahexaenoic acid (DHA) maternal intake contributes to the normal brain development and normal development of the eye of the foetus and breastfed infants. The beneficial effect for pregnant and breastfeeding women is obtained with a daily intake of 200mg of DHA in addition to the recommended daily intake for omega-3 fatty acids for adults (250mg DHA and EPA).

EPA + DHA + ALA: Enhanced Absorption of Essential Omega-3s 25

New Solutions for Real Opportunities

FISH EPA/DHA + CHIA OIL ALA

BLENDS & FORMULATIONS POSITIONING

ALA + EPA/DHA 1812

High ALA Chia Oil (70-80%) + Low EPA/DHA 1812 (30-20%)

ALA + EPA/DHA 3020

ALA Chia Oil + EPA/DHA 3020 (50%-50%)

High ALA Chia Oil + EPA/DHA 3020 (75%-25%)

ALA + EPA/DHA 5020

High ALA Chia Oil + EPA/DHA 5020 (65%-35%)

KEY ADVANTAGES

• FISH OIL PLUS

• REFINED FISH OIL "PLUS"

STRATEGY

• High Volume / Rotation

• Competitive cost

• Supply predictability

• Price stability

• FISH OIL PLUS

• DOUBLE STRENGTH OMEGA-3 PLUS

• ALA/EPA/DHA STRENGTH

• FISH OIL PLUS

• STRENGTH

• CHIA PLUS

• FISH OIL PLUS

• TRIPLE STRENGTH OMEGA-3

• PLUS CARDIOVASCULAR BOOSTER

• Complete omega-3 fatty acid profile increasing nutritional and functional value

• Generate EPA & DHA biosynthesis by ALA + DHA supplementation

• Allergen-free ingredients

• No fishy flavor or reflux

• Low saturated fats

• Improved oxidative stability and organoleptic properties

• 3 Health claims: ALA and Cholesterol, EPA/DHA and Brain and Vision

• MOSH / MOAH EU limit compliant

• Environmentally conscious

• Very cost-effective

• More stable and predictable price and supply

• Optimized PUFAs composition

• Nutritionally balanced

• Volume

• Supply predictability

• Price stability

• Enhanced PUFAs profile

• Triple strength OMEGAs

• Supply predictability

• Price stability

• Highly concentrated TARGET

• Maternity

• Brain and vision health

• Cardio - cholesterol

• Balanced nutrition

Dietary Supplements: Chia Oil Soft Gel Caps

Potential Product Blends & Concepts

ALGAE DHA + CHIA OIL ALA

ALA + DHA, fully plant-based Omega-3s: A full PUFAs offer 20,25

POSSIBLE CONCEPTS/POSITIONINGS

ALGAE CHIA PLUS

ALA + MARINE DHA

FULL VEGAN OMEGAs

OPTIMIZED PUFAs

FULL ANTIOX LIPIDS POTENCY

EFAs METABOLISM BOOSTER

Virgin plant-based chia oil blend

> 60% Essential ALA + refined algal oil

A fully sustainable omega-3 offer from plants

Competitive and predictable prices

STRUCTURE/FUNCTION CLAIMS* | USA

ALA-DHA

Scientific evidence demonstrates that diets that includes omega-3 fatty acids (DHA and ALA) may:

• Strengthens heart health for cardiovascular support.

• Supports immune system.

• Improves brain development during pregnancy and lactation.

• Promotes healthy skin, hair and nails.

HEALTH CLAIMS | EU

Omega-3 ALA

Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels. Recommended daily intake: 2g ALA.

Omega-3 DHA

New Solutions for Real Opportunities

ALGAE DHA + CHIA OIL ALA

BLENDS & FORMULATIONS POSITIONING STRATEGY

ALA + DHA 400

High ALA Chia Oil (70%)

Low DHA (30%)

ALA + EPA/DHA 100 500

High ALA Chia Oil (65%)

Low EPA/DHA (35%)

ALA + EPA

High ALA Chia Oil (60 to 80%)

Low EPA (20 to 40%)

KEY ADVANTAGES

• MARINE + PLANT-BASED OMEGAS PLUS

• ALA + MARINE DHA

• EFAs METABOLISM BOOSTER

• ONLY FULL PLANT-BASED OMEGAS

• FULY OPTIMIZED

• ALA/EPA/DHA Profile

• EFAs METABOLISM BOOSTER

• Full plant-omega3 reserves

• Enhanced DHA metabolism

• Full supply predictability

• Price stability

• Sustainability

• Optimized PUFAs composition

• Nutritionally balanced

• EFAs METABOLISM BOOSTER

• ANTIOX LIPIDS FULL POTENCY

• FULL VEGAN TRIPLE STRENGTH

• Generate EPA biosynthesis by ALA + DHA supplementation

• Allergen-free ingredients

• No fishy flavor or reflux

• 100% Plant-based

• Low saturated fats

• Improved oxidative stability

• 3 Health claims: ALA and Cholesterol, EPA/DHA and Brain and Vision

• MOSH / MOAH EU limit compliant

• Environmentally conscious

• Very cost-effective

• More stable and predictable price and supply

• Optimized viscosity for capsule filling

• Complete pack of bioactive compounds

• Supply predictability

• Price reduction TARGET

• Maternity

• Brain and vision health

• Cardio - cholesterol

• Balanced nutrition

Dietary Supplements: Chia Oil Soft Gel Caps

100% CHIA OIL

100% Plant-based ALA: Omega-3 metabolism booster 20,22

PRODUCT POSITIONING

CHIA PLUS

ENHANCE YOUR OMEGAs-3

FULL PLANT-BASED OMEGAS

BIOACTIVE CHIA POWER

CHIA ACTIVE POWER

ANTIOXIDANT CHIA POWER

STRUCTURE/FUNCTION CLAIMS* | USA

• Support heart and cardiovascular health.

• Reduce inflammation.

• Supports immune system.

HEALTH CLAIMS | EU

Omega-3 ALA

Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels. Recommended daily intake: 2g ALA.

KEY ADVANTAGES

• 100% vegetal

• 63% of plant-based omega-3

• Omega-3 Metabolism Booster

• Generate EPA and DHA biosynthesis by ALA supplementation

• Allergen-free ingredients

• No fishy flavor or reflux

• 100% plant-based

• Low saturated fats

• Improved oxidative stability

• Health claims: ALA and cholesterol

• MOSH / MOAH EU limit compliant

• Environmentally conscious

• Very cost-effective

• Fully predictable price and supply

• High in antioxidants, polyphenols, tocopherols and phytosterols.

TARGET

• Cardio - cholesterol

• Cardio - hypertension/circulation

• Balanced nutrition

Virgin plant-based chia oil > 60% Essential ALA

A fully sustainable omega-3 offer from plants

Competitive omega-3 alternative

Application Concept in Dietary Supplements

ACTIVE INGREDIENTS SUPPLEMENTS NUTRITIONAL BOOSTER

Benexia® Xia Oil is made from our cold-pressed premium chia seeds (Salvia hispanica) through a proprietary extraction process that carefully preserves chia oil's essential fatty acids and bioactive compounds. Chia oil is the richest source of Alpha-linolenic acid omega-3 (63% ALA) and contains important bioactive substances: tocopherols, polyphenols, and phytosterols.

Benexia® Xia Oil also acts as a carrier for liposoluble compounds, boosting their intestinal absorption and enhancing each compound's functionality and efficacy.

CONCEPTS

CHIA OIL + ACTIVE LIPOSOLUBLE COMPOUNDS

The highest plant-based source of alpha-linolenic acid with liposoluble vitamins (K2, retinol, D2/D3, E) and bioactive compounds for effective absorption, inflammation resolution, antioxidant, and immune protection.

KEY ADVANTAGES

• 100% vegetal and sustainable sources of omega-3.

• Lipid delivery system for better absorption

• Non-GMO

• Essential nutrients for healthy body

RECOMMENDED DAILY DOSE 2 capsules per day

1000 mg softgel oblong capsules

Enhanced functionality and efficacy of liposoluble compounds

Formulation Concepts For Active Ingredients Supplements

INGREDIENTS ACTIVE COMPOUNDS

INMUNITY

CHIA OIL + VITAMIN D3

Per 2 Capsules

• Benexia ® Chia Oil: 2000 mg

• Vitamin D3: 50 mcg

STRUCTURE/ FUNCTION CLAIMS* USA

Alpha-Linolenic (ALA) Acid

• Improves heart and cardiovascular health.

• Supports immune system.

• Promotes healthy skin, hair and nails.

Vitamin D

• Essential for bone health.

• Provides immune support.

• Promotes healthy muscle function.

VISION

CHIA OIL + VITAMIN A, ASTAXANTIN AND LUTEIN

Per 2 Capsules

• Alpha-Linolenic (ALA): 1070 mg

• Lutein: 20 mg

• Astaxanthin: 4 mg

Alpha-Linolenic (ALA) Acid

• Improves heart and cardiovascular health.

• Supports immune system.

• Promotes healthy skin, hair and nails.

Astaxantin

• Provides antioxidant protection.

• Naturally supports eye, joint and heart health.

Lutein

• Supports visual function and macular health.

BEAUTY SKIN

CHIA OIL + CO-ENZYME Q10

Per 4 Capsules

• Alpha-Linolenic (ALA): 1700 mg

• Q10: 100 mg

Alpha-Linolenic (ALA) Acid

• Promotes healthy skin, hair and nails.

• Supports the immune system.

Co-enzyme Q10

• Powerful antioxidant and anti-aging.

• Protects cells from damage.

• Helps support heart function.

• Increases energy production.

HEALTH CLAIMS EU TARGET

Alpha-Linolenic (ALA) Acid

Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

Vitamin D

• Contributes maintenance of normal bones and teeth.

• Normal muscle function.

• A normal function of the immune system.

• Immune system.

• Cardio - cholesterol.

• Balanced nutrition.

Alpha-Linolenic (ALA) Acid

Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

• Brain and vision health.

• Antioxidant protection.

• Senior.

Alpha-Linolenic (ALA) Acid

Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

* Claims are subject to local regulation. This product is not intended to diagnose, treat, cure, or prevent any disease.

• Antioxidant protection.

• Hair, skin and nails.

• Cardio - cholesterol.

Chia Oil as a Food Dietary Supplement: Simply add it to your food; it has a great taste!

Natural, plant-based

Essential for your health

Your daily Omega-3

63% omega-3 ALA

Leet your food be your medicine

Take a spoon per day

Light and delicate nutty taste

Ideal for enhancing meals, smoothies, beverages, or soups.

Sustainable food from regenerative agriculture

Application Concept in Dietary Supplements/Functional Foods

BONE HEALTH FOR POSTMENOPAUSAL WOMEN

CALCIUM + VITAMIN D + CHIA OIL ALA POWDER

Calcium and vitamin D are essential for healthy bones. Combining these key nutrients with the highest plant-based source of alpha-linolenic acid (ALA) may support strong bones and reduce joint inflammation as women age.

RECOMMENDED FOR

Women 50 and older

1 in 4 postmenopausal women in both Europe and the U.S. have osteoporosis

1 in 3 women will have an osteoporotic fracture in their lifetime

Fragility-related fractures may increase by 25% by 2034

INGREDIENTS

Benexia ALA Powder 40 (microencapsulated chia oil [70%], acacia gum [30%]), Calcium carbonate, vitamin D, natural flavor and color.

COMPOSITION/NUTRITION FACTS

mg (33% RDA)

RECOMMENDED INTAKE

One 15-g scoop per day

SUGGESTED FORMAT

450g (15.9 oz) jar (30 dosages)

NUTRIENT CONTENT CLAIMS*

• Excellent source of omega-3s | USA

• High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS*

Alpha-Linolenic Acid and Calcium | USA

• Minimizes bone loss

• Supports joint health

• Reduces inflammation

Alpha-Linolenic Acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels.

Calcium | EU

Calcium helps reduce bone mineral loss in postmenopausal women

KEY ADVANTAGES

• Sustainable

• Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Pairing omega-3s with calcium and vitamin D can offer additional bone and joint protection for women ages 50 and older. The benefits from ALA omega-3s may be greater than other forms of omega-3 supplementation such as DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid).

THE EVIDENCE: OMEGA-3S

May enhance calcium absorption

Omega-3 fatty acids may alter the lipid composition of cell membranes, helping cells take in more calcium that can then be put towards building and maintaining bone tissue. These alterations may also reduce rates of calcium loss. May reduce inflammation to reduce bone loss and enhance bone growth

Rates of low-grade inflammation naturally increase with age. Omega-3s offer protection by turning down the production of pro-inflammatory cytokines that may stimulate the breakdown, or resorption, or bone tissue. Simultaneously, these anti-inflammatory properties may also stimulate the formation of healthy new bone tissue.

ALA omega-3 may be particularly effective at these tasks. Compared to supplementing with DHA and EPA, ALA supplementation is tied to:

• Significantly higher levels of Bone-specific alkaline phosphatase (BALP), a bone enzyme involved in generating new bone tissue.

• Lower levels of markers of bone resorption, such as C-terminal telopeptide of type 1 collagen (CTX) and N-terminal telopeptide (NTx).

May enhance physical function

Greater physical activity supports stronger, healthier bones. Among postmenopausal women, dietary intake of ALA omega-3 has been shown to positively impact key parameters of physical function in just three days, including faster walking speed, greater grip strength, lower fat mass, better balance, and increased squatting ability.

BONE METABOLISM

The continuous process of forming new bone tissue and breaking down, or resorbing, old or damaged bone tissue to help bones maintain their structural integrity.

THE

EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, we know that women's bodies are more efficient than men, with a conversion rate of 21% for EPA and 9% for DHA.

More significantly, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.

REFERENCES

Scan the QR code to access scientific references and claim validations.

Application Concept in Dietary Supplements/Functional Foods

FUNCTIONAL COLLAGEN PEPTIDES POWDER FOR POST-MENOPAUSAL WOMEN

EASY-MIX CHIA OIL + COLLAGEN PEPTIDES POWDER

Alpha-linolenic acid (ALA), highly hydrolyzed bovine collagen peptides, and calcium combine synergistically to offer joint protection and bone and anti-inflammatory support in a highly bioavailable, easy-to-mix drink powder.

RECOMMENDED FOR

Women ages 50+

In the U.S., 6,000 women enter menopause each day.1

Musculoskeletal pain increases with age and may be tied to the onset of menopause. 2

INGREDIENTS

Hydrolyzed bovine collagen peptides, Benexia® ALA Powder 40 [chia oil (70%), acacia gum (30%)], calcium carbonate].

COMPOSITION/NUTRITION FACTS

• 1,400 mg ALA omega-3s

• 10 g hydrolyzed bovine collagen peptides

• 400 mg calcium (31% VRN)

1400 mg Omega-3 ALA to

Boost Physical Function

RECOMMENDED INTAKE

Reduce Low-Grade Inflammation

One scoop (15 grams) daily for at least 3 months

SUGGESTED FORMAT

450g (15.9 oz. 0.99lb) jar (30 dosages)

NUTRIENT CONTENT CLAIMS*

Excellent Source of Omega-3 | USA

High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS:

Alpha-linolenic acid | USA

ALA omega-3s promote cardiovascular health

Alpha-linolenic acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels

Calcium | EU

Calcium helps reduce the loss of bone mineral in postmenopausal women

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Declines in the hormone estrogen can lead to or worsen joint pain during and after menopause. Dietary ALA omega-3s may improve joint health and physical capacity in older women, making them an effective way to delay and/ or prevent declines in function.

THE EVIDENCE: ALA AND ENHANCED PHYSICAL FUNCTION

• Women with higher dietary ALA intake show enhanced physical function parameters including faster walking speed, greater grip strength, lower fat mass, and better balance and squatting ability. 3

• Supplementing with omega-3 fatty acids has consistently been shown to relieve joint pain while improving function. 4

THE EVIDENCE: ALA REDUCES LOW-GRADE INFLAMMATION

ALA reduces levels of low-grade inflammation that naturally increase with aging and contribute to musculoskeletal joint pain and functional declines. 5

THE EVIDENCE: OMEGA-3S SUPPORTS MUSCLE HEALTH

Omega-3s contributes to muscle protein synthesis. This can help prevent age-related muscle loss that can lead to frailness.6

THE EVIDENCE: OMEGA-3S AND HEART HEALTH

Estrogen exerts a protective effect on the heart, where declining levels can increase a woman's risk for heart disease, heart attack, and stroke.7 Supplemental omega-3 can play a key role in combatting these problems by aiding in BMI and waist circumference reduction and lower blood pressure and triglycerides. 8

THE EVIDENCE: ALA VS. DHA

When it comes to getting our omega-3 needs met, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.9,10,11

Application Concept in Dietary Supplements/Functional Foods

OMEGA-3 BOOSTER FOR MENOPAUSE SUPPORT

CHIA + ALGAE OIL NUTRITIONAL DROPS

Shifts in the hormone estrogen can cause unpleasant symptoms during the menopausal transition. ALA and DHA omega-3 fatty acids can help manage these symptoms and support overall health.

RECOMMENDED FOR

Women ages 40 and older for perimenopausal and postmenopausal support.

In the U.S., 6,000 women enter menopause each day 1

INGREDIENTS

Chia seed oil, algae oil.

COMPOSITION/NUTRITION FACTS

Alpha-Linoleic Acid (ALA) 2,492 mg

Docosahexaenoic Acid (DHA) 258 mg

RECOMMENDED INTAKE

One tsp (5 mL) up to twice per day.

SUGGESTED FORMAT

130 mL (4.3 oz) bottle (26 dosages).

NUTRIENT CONTENT CLAIMS*

Excellent Source of Omega-3 | USA

High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS*

Alpha-Linolenic Acid | USA

ALA may support the immune system

Alpha-Linolenic Acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels

KEY ADVANTAGES

• Sustainable

• Plant-based source of omega-3s

Up to 80% of women experience menopause symptoms that adversely impact their quality of life and productivity2

Up to 80% of women are short on important nutrients such as omega-3 fatty acids 3

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Women become less effective at converting ALA omega-3s to DHA omega-3s during the menopausal transition. Supplementing with ALA and DHA omega-3s can support this reduced capacity, and in turn, help manage menopause-related symptoms.

THE EVIDENCE: WOMEN AND OMEGA-3 CONVERSION Research shows that younger women convert alphalinolenic acid (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) much more efficiently than men, in large part thanks to estrogen. As estrogen levels decline during menopause, the synthesis of ALA to DHA becomes downregulated, making omega-3 supplementation essential. 4,5,6

THE EVIDENCE: OMEGA-3S IN MENOPAUSE

The menopausal transition is associated with an increased risk for a range of symptoms and conditions. Many of those issues can be better managed with the help of supplemental omega-3 fatty acids, including:

• Heart Health. Estrogen exerts a protective effect on the heart, where declining levels can increase a woman's risk for heart disease, heart attack, and stroke[7]. Supplemental omega-3 can play a key role in combatting these problems by aiding in BMI and waist circumference reduction and lower blood pressure and triglycerides[8].

• Mood and Brain Fog. The risk for mood disorders and cognitive impairment increases in menopause. Research suggests that supplementing with omega-3s can improve depressive symptoms while enhancing critical aspects of cognition related to motivation, such as energy and alertness[9].

• Joint Pain. Thanks to hormone shifts and the natural effects of aging, more than half of women experience joint pain during and after menopause. Supplementing with omega-3 fatty acids has consistently been shown to relieve joint pain while improving function[10].

• Night Sweats And Sleep Disruption. Hormone shifts can lead to night sweats that cause discomfort and disrupt. However, omega-3 supplements may help alleviate night sweats, which in turn can lead to more comfortable, less fragmented sleep[11].

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.

REFERENCES

Scan the QR code to access scientific references and claim validations.

Application Concept in Dietary Supplements/Functional Foods

MALE FERTILITY AND REPRODUCTIVE HEALTH

CHIA OIL + UBIQUINOL (COQ10)

The highest plant-based source of alpha-linoleic acid (ALA) joins forces with the most active form of coenzyme Q10 to support sperm quality, modulate male reproductive hormones, and support vascular health.

RECOMMENDED FOR Men

Global rates of male fertility have steadily decreased since 1990

15% of couples worldwide are affected by infertility

Male factors contribute to about 50% of infertility cases

COMPOSITION/NUTRITION FACTS 1,200 mg Alpha-linoleic Acid

Improves sperm quality, modulates hormone health, reduces inflammation

Exerts anti-inflammatory effect; improves sperm density, motility, and morpholog

RECOMMENDED INTAKE

Two capsules daily

SUGGESTED FORMAT

Softgel capsules

NUTRIENT CONTENT CLAIMS*

• Excellent Source of Omega-3 | USA

• High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS*

Alpha-Linolenic Acid and Q10 | USA

• Optimizes fertility

• Supports sperm health

• Supports vascular and heart health

Alpha-Linolenic Acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels.

KEY ADVANTAGES

• Sustainable

• Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Omega-3 supplements can play a key role in supporting male fertility through a number of different avenues, emerging research suggests. Combining omega-3s with ubiquinol may offer additional anti-inflammatory benefits.

Sperm Motility: Ability of sperm to move efficiently

Sperm Morphology: The shape and structure of sperm cells

Sperm Density: Number of sperm in a given volume of semen

Functional Competence: Ability of sperm to fertilize an egg

THE EVIDENCE: OMEGA-3S

May improve sperm quality.

Higher levels of omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are tied to higher sperm counts and greater sperm motility and morphology. Omega-3 supplements may also help sperm maintain their structural integrity and functional competence by fighting against oxidative stress.

May modulate hormone production.

EPA and DHA supplementation may enhance the production of the male reproductive hormone testosterone. That may provide a healthier environment for sperm production and maturation.

May reduce inflammation.

Omega-3's anti-inflammatory properties counteract the effects of chronic inflammation in the testes and the seminal vesicles. This also supports healthy sperm production and function.

THE EVIDENCE: UBIQUINOL (COENZYME Q10)

Men with unexplained low sperm count may benefit from ubiquinol. Supplements can exert an antioxidant effect that has been shown to improve sperm density, sperm motility, and sperm morphology.

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. But methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels in the body.

REFERENCES

Scan the QR code to access scientific references and claim validations.

Application Concept in Dietary Supplements/Functional Foods

INSTANT PORRIDGE

ABSORPTION-OPTIMIZED NUTRIENT

BLEND

FOR ELDERLY

EASY-MIX CHIA OIL POWDER

Cognitive and neurologic support from alpha-linolenic acid (ALA) omega-3s for older adults, offered in a highly bioavailable, tasty stir-and-serve porridge.

RECOMMENDED FOR

Senior adults

INGREDIENTS

Benexia® ALA Powder 40 [Chia Oil (70%), Acacia Gum (30%)], quinoa flour, rice flour, modified corn starch, pea protein, calcium carbonate, vitamins and minerals, inulin, natural banana flavor, arabic gum, tocopherols, ascorbil palmitate, guar gum.

COMPOSITION/NUTRITION FACTS

Per 4 tablespoons (50 g) powder (250 g reconstituted product):

Nutrition Facts

Serving size (250 g reconstituted product)

Amount per Serving

The % Daily Value tells you

RECOMMENDED INTAKE

Four tablespoons (50 g) prepared with 200ml of milk, water, or any nutritional formula up to twice daily.

The world's older population (ages 60+) will jump by 56% in the next 10 years.1

The number of older adults with dementia worldwide is projected to double by 2030, reaching 78 million. 2

Dietary supplements are widely recognized as a way to enhance cognitive ability and prevent or slow decline. 3

mg Omega-3 ALA for

SUGGESTED FORMAT

300g pack (6 servings).

NUTRIENT CONTENT CLAIMS*

Excellent Source of Omega-3 | USA

High Omega-3 Fatty Acids | EU

With more than 600 mg of omega-3 ALA per serving

HEALTH CLAIMS*

Alpha-linolenic acid | USA

• ALA omega-3s promote cardiovascular health

• ALA omega-3s may support immune health

Alpha-linolenic acid | EU ALA contributes to the maintenance of normal blood cholesterol levels.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: In summary: Adequate or supplementary ALA omega-3s may offer protection for older adults against cognitive declines and neurologic conditions like stroke.

THE EVIDENCE: ALA OMEGA-3S AND COGNITIVE DECLINE

• Dietary intake of omega-3 fatty acids during older adulthood may reduce the risk of all-cause dementia or cognitive decline by 20%. 4

• ALA supplementation during midlife, years before the onset of Alzheimer's disease (AD) symptoms may help prevent or ameliorate slowed brain glucose metabolism, which contributes to the development of AD. 5

THE EVIDENCE: ALA OMEGA-3S AND NEUROLOGIC PROTECTION

• ALA supplementation supports brain health and increases antioxidant activity by increasing levels of brain-derived neurotrophic factors (BDNF), which promotes the growth of new nerve cells in the brain.6

• Low levels of BDNF may increase stroke risk and inhibit stroke recovery, while targeting BDNF levels may support stroke recovery7, suggesting that ALA may support recovery from neurologic conditions like stroke. 8

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.9,10,11

REFERENCES

Scan the QR code to access scientific references and claim validations.

Application Concept in Dietary Supplements/Functional Foods

POST-WORKOUT ALA SMOOTHIE FOR SPORTS RECOVERY

ANTI-INFLAMMATORY CHIA OIL SMOOTHIE

Optimize sports recovery and shorten time between workouts with a convenient, ready-to-drink smoothie with alpha-linolenic (ALA) omega-3 fatty acids, high-quality protein, and natural antioxidants.

RECOMMENDED FOR

High-performance athletes

INGREDIENTS

Mixed berry juice from concentrate, whey protein, pectin, Benexia Chia Oil (63% ALA), natural raspberry flavor, sunflower seed protein, rosemary extract, tocopherols.

COMPOSITION/NUTRITION FACTS

Supplement Facts

Serving Size: 1 (8.45 FL OZ) (250 mL)

* The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2000 calories a day is used for general nutrition advice.

RECOMMENDED INTAKE

One serving (250 ml ) up to twice per day.

SUGGESTED FORMAT

Athletes may be at higher risk for omega-3 insufficiencies.1

Omega-3 supplementation can improve deficiencies and yield performance and recovery benefits.

250 ml bottle (1 dosage). 1600 mg Omega-3 ALA for

High Athletic Performance Muscle Repair, Refuel & Recovery

NUTRIENT CONTENT CLAIMS

Excellent Source of Omega-3 | USA

High in Omega-3 Fatty Acids | EU

Excellent Source of Protein | USA

High Protein | EU

HEALTH CLAIMS*

Alpha-Linolenic Acid | USA

• Strengthen heart health for cardiovascular support

• Support immune system

Alpha-Linolenic Acid | EU

ALA contributes to the maintenance of normal blood cholesterol levels.

KEY ADVANTAGES

• Sustainable

• Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Science

IN SUMMARY: Omega-3s may help athletes perform at a higher level during physical activity and experience faster recovery times with less muscle discomfort.

THE EVIDENCE: ALAS AND MUSCLE PERFORMANCE

High consumption of ALA (1.9 g/day) is tied to better aerobic performance compared to low consumption of ALA (0.75 g/day). ALA has been shown to improve oxygen use efficiency. It also promotes the use of fat for energy during prolonged exercise after carbohydrate sources have been depleted. 2

THE EVIDENCE: OMEGA-3S AND RECOVERY

Omega-3 supplementation may turn down the body's inflammatory response and decrease oxidative stress after exercise. This may reduce exercise-induced muscle damage, which in turn may support faster recovery times. 3

THE EVIDENCE: OMEGA-3S + WHEY PROTEIN

High-quality protein sources like whey have long been known to support muscle recovery after physical activity. Consuming whey with omega-3 fatty acids before exercising may add to these benefits. The combination has been shown to improve strength and power and reduce delayed-onset muscle soreness. 4

THE EVIDENCE: ALA VS. DHA

When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels. 5,6,7

REFERENCES

Scan the QR code to access scientific references and claim validations.

Nutritional Data Sheet

PRODUCT

Benexia® Xia Oil

REFERENCE CODE

OIL

OILO

DATE

June 2023

1: As this is a natural product, the values reported as typical may vary.

2: Calorie calculation (common conversion factors): In the US, use the 4-4-9 method, which assumes that each gram of protein contributes 4 calories to the caloric total, each gram of carbohydrates contributes 4 calories (less the amount of non-digestible carbohydrates), and each gram of fat contributes 9 calories (FDA).

3: In Canada and in the European Union, use the 4-4-9 adjusted for fiber. A value of 2 calories (8 kJ) per gram should be used for the dietary fiber portion of the fiber source.

Technical Data Sheet

PRODUCT

Benexia® Xia OIl

REFERENCE CODE

XIA OIL

DATE May 2023

DESCRIPTION

Benexia® Xia Oil is a golden-colored, transparent, and brilliant oil obtained through a proprietary premium technology, ensuring the most natural cold-press extraction of plant-based omega-3 from chia seed (Salvia hispanica L.).

INGREDIENTS

100 % chia oil

FORMAT AND PACKAGING MATERIAL

190 Kg enamelled drum

Packed under modified atmosphera (MA), replacing oxygen by nitrogen.

BEST BEFORE DATE AND STORAGE

24 months, stored in a cool dry place in original unopened package.

Recommended storage conditions: Temperature <20 oC and <60 % of relative humidity. Once opened, it is recommended to consume the whole drum or refill with nitrogen before sealing.

CERTIFICATIONS

FSSC 22000

Halal and Kosher

QUALITY ASSURANCE

Additives: Free GMO: Free

Allergens: According to allergen assessment.

Contaminants: Comply with regulation.

Suitable diets: Gluten free, vegetarian, vegan, keto, and low carb.

APPLICATIONS

Food, beverage, and nutraceutical ingredient.

REGULATION

Chia oil has been approved as Novel Food (Commission Decision 2014/890/EU).

Custom Tariff Code: 15.15.9090

Origin: Chile.

* Or equivalent method ** At the end of the shelf-life period, if it has been stored according to instructions. The typical value at the date of manufacture is <2 meq O2/Kg. 1: Analysed per lot production 2: Analysed per yearly productions

Xia Oil Organic

Technical Data Sheet

PRODUCT

Benexia® Xia Oil Organic

REFERENCE CODE

XIA OIL O

DATE

May 2023

DESCRIPTION

Benexia® Xia Oil Organic is a golden-colored, transparent, and brilliant oil obtained through a proprietary premium technology, ensuring the most natural cold-press extraction of plant-based omega-3 from chia seed (Salvia hispanica L.).

INGREDIENTS

100 % chia oil organic.

FORMAT AND PACKAGING MATERIAL

190 Kg enamelled drum

Packed under modified atmosphera (MA), replacing oxygen by nitrogen.

BEST BEFORE DATE AND STORAGE

24 months, stored in a cool dry place in original unopened package.

Recommended storage conditions: Temperature <20 oC and <60 % of relative humidity. Once opened, it is recommended to consume the whole drum or refill with nitrogen before sealing.

CERTIFICATIONS

FSSC 22000

Halal and Kosher

Organic under EU regulation. Organic quality NOP/USDA - COR equiv.

QUALITY ASSURANCE

Additives: Free GMO: Free

Allergens: According to allergen assessment.

Contaminants: Comply with regulation. Suitable diets: Gluten free, vegetarian, vegan, keto, and low carb.

APPLICATIONS

Food, beverage, and nutraceutical ingredient.

REGULATION

Chia oil has been approved as Novel Food (Commission Decision 2014/890/EU).

Custom Tariff Code: 15.15.9090

Origin: Chile.

Microbiological

Nutritional Data Sheet

PRODUCT

Benexia® ALA Powder

REFERENCE CODE

ALA Powder

DATE

July 2023

1: As this is a natural product, the values reported as typical may vary.

ALA Powder 40

Technical Data Sheet

PRODUCT

Benexia® ALA Powder 40

REFERENCE CODE ALA Powder 40

DATE October 2024

DESCRIPTION

Benexia® ALA Powder 40 is a microencapsulated spray-dried Benexia® Xia Oil and Acacia gum with 40% omega-3 content. This soluble powder has no taste and boasts a very good oxidative stability.

INGREDIENTS

Chia oil and acacia gum

FORMAT AND PACKAGING MATERIAL 20 Kg with inner lines and oxygen barrier bag.

BEST BEFORE DATE AND STORAGE 18 months, stored in a cool dry place in original unopened package.

Recommended storage conditions: Temperature <20 oC and <60 % of relative humidity. Once opened keep refrigerated.

QUALITY ASSURANCE

Allergen: Free Gluten free, vegetarian, and vegan.

APPLICATIONS

Food, beverage, and nutraceutical.

REGULATION

Origin: Malaysia

References

1. Djuricic, I., & Calder, P. C. (2021). Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Nutrients, 13(7), 2421. https://doi.org/10.3390/ nu13072421.

2. Lauritzen, L., Hansen, H. S., Jørgensen, M. H., & Michaelsen, K. F. (2001). The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Progress in lipid research, 40(1-2), 1-94. https://doi.org/10.1016/s0163-7827(00)00017-5.

3. Coletta, J. M., Bell, S. J., & Roman, A. S. (2010). Omega-3 Fatty acids and pregnancy. Reviews in obstetrics & gynecology, 3(4), 163-171.

4. Greenberg, J. A., Bell, S. J., & Ausdal, W. V. (2008). Omega-3 Fatty Acid supplementation during pregnancy. Reviews in obstetrics & gynecology, 1(4), 162-169.

5. Valenzuela, R., Bascuñán, K., Chamorro, R., Barrera, C., Sandoval, J., Puigrredon, C., Parraguez, G., Orellana, P., Gonzalez, V., & Valenzuela, A. (2015). Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing.Nutrients, 7(8), 6405-6424. https://doi.org/10.3390/nu7085289.

6. Su, K. P., Huang, S. Y., Chiu, T. H., Huang, K. C., Huang, C. L., Chang, H. C., & Pariante, C. M. (2008). Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry, 69(4), 644-651. https://doi. org/10.4088/jcp.v69n0418 .

7. Hsu, M. C., Tung, C. Y., & Chen, H. E. (2018). Omega-3 polyunsaturated fatty acid supplementation in prevention and treatment of maternal depression: Putative mechanism and recommendation. Journal of affective disorders, 238, 47-61. https://doi.org/10.1016/j.jad.2018.05.018.

8. Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation. Metherel, Adam H. et al. Journal of Lipid Research, Volume 65, Issue 6, 100548.

9. Sobrino A, Walker ME, Colas RA, Dalli J (2020) Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators. PLoS ONE 15(12): e0242543.

10. Naghshi S, et al. Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies BMJ 2021; 375:n2213.

11. Guizy, M., David, M., Arias, C., Zhang, L., Cofán, M., Ruiz-Gutiérrez, V., Ros, E., Lillo, M. P., Martens, J. R., & Valenzuela, C. (2008). Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid. Journal of molecular and cellular cardiology, 44(2), 323-335. https:// doi.org/10.1016/j.yjmcc.2007.11.004.

12. Aleix Sala-Vila, Jennifer Fleming, Penny Kris-Etherton, Emilio Ros, Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition, Advances in Nutrition, 2022;, nmac016, https://doi.org/10.1093/advances/nmac016.

13. Rallidis, L. S., Paschos, G., Liakos, G. K., Velissaridou, A. H., Anastasiadis, G., & Zampelas, A. (2003). Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis, 167(2), 237-242. https://doi.org/10.1016/s00219150(02)00427-6.

14. Zhao, G., Etherton, T. D., Martin, K. R., Gillies, P. J., West, S. G., & Kris-Etherton, P. M. (2007). Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. The American journal of clinical nutrition, 85(2), 385-391. https://doi.org/10.1093/ajcn/85.2.385.

15. Abdelhamid AS, et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2020, Issue 3. Art. No.: CD003177.

16. Vuksan, V., Whitham, D., Sievenpiper, J. L., Jenkins, A. L., Rogovik, A. L., Bazinet, R. P., Vidgen, E., & Hanna, A. (2007). Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trial. Diabetes care, 30(11), 2804-2810. https://doi.org/10.2337/dc07-1144.

17. Lacombe R et al (2020) Turnover of brain DHA in mice is accurately determined by tracer-free natural abundance carbon isotope ratio analysis. J Lipid Res Jan;61(1):116-126.

18. Saunders DR, Sillery JK. Absorption of triglyceride by human small intestine: dose-response relationships. Am J Clin Nutr 1988; 48:988-91.

19. Burdge GC. Metabolism of -linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids 2006; 75:161-8.

20. Lin, Y.-H., Hibbeln, J.R., Domenichiello, A.F., Ramsden, C.E., Salem, N.M., Chen, C.T., Jin, H., Courville, A.B., Majchrzak-Hong, S.F., Rapoport, S.I., Bazinet, R.P. and Miller, B.V., III (2018), Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State. Lipids, 53: 547-558.

21. Metherel A, et al (2019) Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a randomized control trial. Am J Clin Nutr 110(4) 823-831.

22. Kim HK, Choi H. Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane. Lipids 2001; 36:1331-6.

23. Domenichiello A, et al (2015) Is docosahexaenoic acid synthesis from a-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research 59; 54-66.

24. Anthony F Domenichiello, Alex P Kitson, Adam H Metherel, Chuck T Chen, Kathryn E Hopperton, P Mark Stavro, Richard P Bazinet, Whole-Body Docosahexaenoic Acid Synthesis-Secretion Rates in Rats Are Constant across a Large Range of Dietary α-Linolenic Acid Intakes1, The Journal of Nutrition, Volume 147, Issue 1, 2017, Pages 37-44, ISSN 0022-3166.

25. Anthony F. Domenichiello, Alex P. Kitson, Chuck T. Chen, Marc-Olivier Trépanier, P. Mark Stavro, Richard P. Bazinet, The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats, The Journal of Nutritional Biochemistry, Volume 30, 2016, Pages 167-176.

26. Demar Jr JC, Ma K, Chang L, Bell JM, Rapoport SI. alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J Neurochem 2005;94:1063-76.

27. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n3 to 22:6n3 in vivo. A stable isotope tracer study. J Lipid Res 2001;42:581-6.

28. Su HM, Bernardo L, Mirmiran M, Ma XH, Corso TN, Nathanielsz PW, et al. Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. Pediatr Res 1999;45:87-93.

29. Rapoport SI, Rao JS, Igarashi M. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostag Leukotr Essent Fatty Acids 2007;77:251-61.

30. Umhau JC, Zhou W, Carson RE, Rapoport SI, Polozova A, Demar J, et al. Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J Lipid Res 2008.

31. J Thomas Brenna. DHA retroconversion revisited: dietary DHA spares endogenous EPA. Am J Clin Nutr 2019;110:789-790.

32. Poumes-Ballihaut C, Langelier B, Houlier F, Alessandri JM, Durand G, Latge C, et al. Comparative bioavailability of dietary alpha-linolenic and docosahexaenoic acids in the growing rat. Lipids 2001; 36:793-800.

33. Demar Jr JC, Ma K, Chang L, Bell JM, Rapoport SI. alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J Neurochem 2005;94:1063-76.

34. Barcelo-Coblijn G, Collison LW, Jolly CA, Murphy EJ. Dietary alpha-linolenic acid increases brain but not heart and liver docosahexaenoic acid levels. Lipids 2005;40:787-98.

35. Innis SM, Dyer RA. Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid. J Lipid Res 2002; 43:1529-36.

36. Portolesi R, Powell BC, Gibson RA. Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. J Lipid Res 2007; 48:1592-8.

37. Bordoni A, Lopez-Jimenez JA, Spanò C, Biagi P, Horrobin DF, Hrelia S. Metabolism of linoleic and alphalinolenic acids in cultured cardiomyocytes: effect of different N-6 and N-3 fatty acid supplementation. Mol Cell Biochem 1996; 157:217-22.

38. Igarashi M, Ma K, Chang L, Bell JM, Rapoport SI. Rat heart cannot synthesize docosahexaenoic acid from circulating alpha-linolenic acid because it lacks elongase-2. J Lipid Res 2008; 49: 1735-45.

39. Adam H. Metherel, R.J. Scott Lacombe, Juan J. Aristizabal Henao, Delphine Morin-Rivron, Alex P. Kitson, Kathryn E. Hopperton, Daniel Chalil, Mojgan Masoodi, Ken D. Stark, Richard P. Bazinet, Two weeks of docosahexaenoic acid (DHA) supplementation increases synthesis-secretion kinetics of n-3 polyunsaturated fatty acids compared to 8 weeks of DHA supplementation, The Journal of Nutritional Biochemistry,Volume 60,2018, Pages 24-3 4, ISSN 0955-2863.

40. Barcelo-Coblijn G, Kitajka K, Puskas LG, Hogyes E, Zvara A, Hackler Jr L, et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n6 to n3 fatty acid ratio. Biochim Biophys Acta 2003;1632:72-9.

41. Kim HK, Choi H. Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane. Lipids 2001; 36:1331-6.

42. Spady DK. Regulatory effects of individual n6 and n3 polyunsaturated fatty acids on LDL transport in the rat. J Lipid Res 1993;34:1337-46.

43. Ayalew-Pervanchon A, Rousseau D, Moreau D, Assayag P, Weill P, Grynberg A. Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo. Am J Physiol Heart Circ Physiol 2007; 293:H2296-304.

44. Abedin L, Lien EL, Vingrys AJ, Sinclair AJ. The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig. Lipids 1999;34:475-82.

45. McLennan PL, Dallimore JA. Dietary canola oil modifies myocardial fatty acids and inhibits cardiac arrhythmias in rats. J Nutr 1995;125:1003-9.

46. Burdge GC, Jones AE, Wootton SA. Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. Br J Nutr. 2002;88(4):355-364. (PubMed).

47. Burdge GC, Wootton SA. Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002;88(4):411-420. (PubMed).

48. Burdge G. α-Linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care. 2004;7(2):137-144. (PubMed).

49. Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr. 2004;80(5):1167-1174. (PubMed)

50. Burdge GC, Calder PC. Dietary α-linolenic acid and health-related outcomes: a metabolic perspective. Nutrition Research Reviews. 2006;19(1):26-52. doi:10.1079/NRR2005113.

51. Metherel AH, Irfan M, Chouinard-Watkins R, Trépanier MO, Stark KD, Bazinet RP. DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long-Evans Rats. J Nutr. 2019 Apr 1;149(4):586-595.

52. Metherel AH, Klievik BJ, Cisbani G, Smith ME, Cumberford G, Bazinet RP. Blood and tissue docosahexaenoic acid (DHA, 22:6n-3) turnover rates from Ahiflower® oil are not different than from DHA ethyl ester oil in a diet switch mouse model. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Jan;1869(1):159422.

53. Metherel A, Bazinet R (2019) Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion. Prog Lipid Res Oct; 76:101008.

Benexia Ingredients

BENEXIA® BLACK AND WHITE CHIA SEED

BCS R Benexia® Black Chia Seed Raw.

BCS O R Benexia® Black Chia Seed Organic Raw.

BCS LM Benexia® Black Chia Seed Low Moisture, pasteurized, RTE.

BCS O LM Benexia® Black Chia Seed Organic Low Moisture, pasteurized, RTE.

WCS R Benexia® White Chia Seed Raw.

WCS O R Benexia® White Chia Seed Raw.

WCS LM Benexia® White Chia Seed Low Moisture, pasteurized, RTE.

WCS O LM Benexia® White Chia Seed Organic Low Moisture, pasteurized, RTE.

BENEXIA® XIA OIL: FATS INGREDIENTS

Benexia® Xia Oil is chia oil, obtained through a proprietary premium technology, for a natural cold-press extraction of the chia seed (Salvia hispanica L.).

It contains 63% of omega-3.

XIA OIL

Benexia® Xia Oil offers great opportunities to develop products in foods and beverage. We offer formulations for a broad range of food applications in fats, oils blends, flavored oils, vegetable spreads, bakery, dairy, juices, condiments, and specialty retail oils.

XIA OIL O

Benexia® Xia Oil Organic.

BENEXIA® XIA POWDERS: PROTEIN AND FIBER SOURCES

Xia Powder 125 LM is a fine and dispersible chia protein powder, concentrated up to 42%. Xia Powder 435 LM is a fine chia fiber powder, concentrated up to 56% and with more protein than chia seed. Both are manufactured from the partially defatted Benexia® Chia, obtained through MicroTech® technology.

XIA POWDER 125 W LM

Xia Powder 125 White Low Moisture.

XIA POWDER 125 W O LM

Xia Powder 125 White Organic Low Moisture.

XIA POWDER 435 W LM

Xia Powder 435 White Low Moisture.

XIA POWDER 435 W O LM

Xia Powder 435 White Organic Low Moisture.

BENEXIA® PREMIXES

This line offers this amazing nutrition found in chia seed in high-fiber, high-protein bakery premixes. These premixes check all the boxes: texture, taste, simplicity and fortification. All the premixes include our ingredient Benexia® Xia Powder 435 W LM.

KETO/LOW-CARB

GLUTEN-FREE

GLUTEN-FREE AND KETO/LOW-CARB HIGH FIBER

W stands for white, ground from white chia seeds.

LM means Low Moisture. The ingredient is processed through Microtech® technology.

O indicates products from controlled organic cultivation.

Benexia®, a leader in the industry

Launched in 2000, Benexia® is a world leader in the production, processing, and commercialization of chia and chia-based ingredients. Our company is vertically integrated from agricultural production to final ingredients and solutions, including plant cultivation, extraction, concentration processes, and ingredients development.

We guarantee traceability from the fields and certified quality (GAP, GMP-HACCP, and FSSC 22000). Benexia products are certified Halal and Kosher.

Sustainability and Corporate Responsibility

Benexia employs regenerative agriculture to achieve lower carbon and water footprints from planting to harvesting. These practices are incorporated by the brand's farming partners in Bolivia, Argentina, and Paraguay. Harvested chia seeds are processed without the use of gas or water. Seeds are cleaned and separated using physical processes such as airflow and density-based separation methods, yielding a final seed product that's 99.95% pure.

Since its founding in 2005, Benexia is dedicated to supporting the welfare of its local communities. Benexia is aligned with the United Nations' Sustainability Development Goals and is on track to complete its B Corp certification by 2025. Half of Benexia's partner shareholders are chia farmers. This guarantees fair pricing and technical support within the company's supply chain as well as full traceability of ingredients.

Our team, the best customer service

We're passionate about health, wellbeing, and providing exceptional service for our customers. We offer support in formulation, nutrition, scientific and regulatory matters, with the best experts to assist your needs.