Xia Oil, a New Sustainable Source of Omega-3 ALA

Chia Ingredients

XIA OIL, A NEW NATURAL SUSTAINABLE SOURCE OF OMEGA-3

Chia Oil for dietary supplement applications

An Ancient Superfood for the 21st Century

The Power of Chia

The seeds of change may start small, but in the right environment, they grow mighty. That can certainly be said of the chia plant, whose minuscule seed grains nourished ancient civilizations for centuries - and has, in recent decades, experienced a revitalization as a superfood ideal for meeting the needs of modern consumers.

Most call Chia a seed, though it’s technically a grain. Regardless of how consumers categorize it, the tiny black or white orbs far surpass their seed or grain counterparts when it comes to nutrition: Chia brings together protein, omega-3 fatty acids, fiber, antioxidants, and an array of minerals, all in a package no bigger than a pinhead.

An ancient food with the highest omega-3 content found in nature: with unsuspected health benefits, chia is an amazing sustainable source of essential nutrients.

A unique nutritional profile has enabled for chia to sustain civilizations such as the Aztecs and the Mayans. Today, a mounting body of evidence shows that the grain has the potential to aid in addressing some of our most pressing health concerns, including heart disease, diabetes, inflammation, and neurocognitive and neurodegenerative conditions. Chia’s nutritional components have also proven integral to fetal and child development, positioning it to support the health of coming generations through pre- and postnatal nutrition.

The versatile grains can be enjoyed whole (both raw or soaked) or cold-pressed into a nutrient-dense oil, while the leftover matter can be ground in a fiber- and protein-rich flour.

The fact that chia is plant-based, free of gluten, zero net carbs, and high in protein has also made it popular among multiple dietary patterns, including vegan, lowcarb/keto, and gluten-free diets.

40% of Dietary Fiber 22% of Proteins 20% of Omega-3 6% of Omega-6 1:4 omega-6:omega-3 ratio

High levels of antioxidants, tocopherols, and plant sterols

A Highly Sustainable Food Source

Chia, too, is a food that supports the health of the planet. Requiring few resources to thrive in its native environment, the crop supports humanity’s need for increased sustainability, reduced water usage, and fewer greenhouse gas emissions in our global food supply.

Chia is, by its very nature, a highly sustainable crop. Grown in its native South America, where it evolved to thrive—it’s the right plant for the right place—and can be grown with minimal additional resources. Benexia, a fully integrated company specializing in the production, processing, and commercialization of chia and chia-based ingredients, has built on these inherent qualities to yield an eco-friendly farming production process that gives back to the local environment, local communities, and the planet at large. Ultimately, chia is a food people can feel good about.

99.95%

the level of purity of chia seeds grown, cleaned and processed by Benexia

After a couple of years of carefully monitored harvests, chia fields are left to rest crop-free for 1-2 years during which grasses are planted and animals can graze. Once the land has been fully replenished and the soil’s inherent nutrient composition is again optimal, a new crop is planted. These crop rotation practices support healthier soil, which in turn yields greater crop resilience as well as more reliable local economic activity.

Chia’s nutrition, sustainability, and versatility make it a highly appealing option for consumers and food manufacturers.

CLEAN, NO-WASTE PRODUCTION METHODS

Fresh from the field, Benexia's newly-harvested chia seeds are processed without the use of gas or water. Seeds are cleaned and separated using physical processes such as airflow and density-based separation methods, yielding a final seed product that's 99.95% pure.

From there, all parts of the seeds are used to ensure that nothing is lost - and no resources are wasted. After the seeds are cleaned, they are pasteurized with a specialized, organically certified process that uses no solvents, chemicals, or water, while the omega-3 rich chia oil is extracted from the seeds via a single cold pressing to retain maximum nutrition capacity. The oil is cleaned and purified through a filter, that, again, requires no chemicals or solvents.

Once the oil is extracted from the seeds, the leftover fibrous matter is dried and milled to separate the fiber from the protein. The powdered chia fiber and protein, now a fine flour, can be incorporated into baked goods, pizza crusts, breads, and more, as a source of zero-waste, functional nutrition.

CORPORATE RESPONSIBILITY

Considering Benexia's commitment to the planet, it may come as no surprise that, since its founding in 2005, the company is equally dedicated to supporting the welfare of its local communities. Benexia is aligned with the United Nations’ Sustainable Development goals and is on track to complete its B Corporation certification by 2023.

As a vertically integrated company, 50% of Benexia's partner shareholders are chia seed farmers. This guarantees fair pricing and technical support within the company's supply chain as well as full traceability of their ingredients.

Benexia® Xia Oil

Cold-pressed from fresh, high quality, low-moisture chia seeds, chia oil is a pure, unrefined oil made without chemical solvents or diluents. Benexia's careful processing preserves chia's liposoluble nutrients and bioactive components, resulting in an oil with the highest concentration of essential omega-3 fatty acids among plant-based cooking oils.

Chia oil is a natural and extra virgin oil; therefore, it is free of MOAH*. Also, its content in MOSH** is very under the regulatory limits.

With 63% of chia oil’s total fat consisting of omega-3 ALAs, just one teaspoon provides twice the recommended daily ALA intake, qualifying as an “excellent source.”

Additionally, chia oil is the edible vegetable oil with the largest content of Omega-3 fatty acids found in nature: over 63% of this oil is composed of this fatty acid. In addition to the high content of Omega-3, chia oil contains significant quantities of bioactive substances, contributing to its outstandingly high Oxygen Radical Absorbance Capacity (ORAC), excellent Oxidative Stability, and significant Health Benefits.

** MOSH stands for Mineral Oil-Saturated Hydrocarbons, which are a health concern. They are paraffin-like, open-chained, commonly branched hydrocarbons (e.g., alkanes) and naphthene-like cyclic hydrocarbons (cycloalkanes). MOSH accumulates in the liver and lymphoid system, causing inflammation. MOSH/POSH (sum) <5 mg/kg. The most likely cause of its presence in chia oil and the oils industry is transfer through the packaging material.

* MOAH stands for Mineral Oil Aromatic Hydrocarbons.

Fatty Acid Profile & Bioactive Components

FATTY ACIDS PROFILE

Polyunsaturated Fatty Acids

C18:2n6 Linoleic Acid 19 >15

C18:3n3 Alpha Linolenic Acid (ALA) 63 >60

C20:2n6 Eicosodienoic Acid 0.05 -

C20:3n6 Eicosatrienoic Acid 0.05 -

C20:3n3 Eicosatrienoic Acid 0.1

C20:4n6 Arachidonic Acid 0.05 -

C20:5n3 Eicosapentaenoic Acid (EPA) 0 -

C22:5n3 Docosapentaenoic Acid 0.01 -

C22:6n3 Docosahexaenoic Acid

BIOACTIVE COMPONENTS: OXIDATIVE STABILITY AND HEALTH BENEFITS Antioxidants and Polyphenols

63% of Omega-3 19% of Omega-6 ORAC >2500 μmol/TE

Bioactive Compounds Phytosterols, Tocopherols Polyphenols

Health Benefits

Caffeic acid and Coumaric acid showed a positive effect on reducing carcinogenic incidence. It is known to have antimitogenic, anticarcinogenic, anti-inflammatory and immunomodulatory properties. Tocopherols

Health Benefits

Emerging data reveal that gamma tocopherol supplies potent protection against cardiovascular disease, cancer, and even neurodegenerative conditions. Gamma tocopherol has superior anti-inflammatory and gene regulatory activities, while alphatocopherol remains a potent antioxidant.

Health Benefits

Numerous clinical trials have demonstrated that daily consumption of foods enriched with plant sterols or stanols lowers serum LDL cholesterol. In addition to the cholesterollowering and anti-cancer properties of phytosterols, there is also evidence that these components have antioxidant activity.

Omega-3 to Omega-6 ratio in Benexia Chia Oil: balance your Omega’s

TYPICAL AMERICAN DIET

The typical American diet contains a high level of inflammatory omega-6s and not enough omega-3s.

THE PERFECT BALANCE

A ratio of 1-4:1 of omega-6 to omega-3 is the perfect balance beetween these fatty acids.

An imbalanced omega-6 to omega-3 ratio may lead to inflammation and chronic diseases. Many health experts suggest we consume less omega-6s and more omega-3s.

COMMON VEGETABLE OILS

Many common vegetable oils contain a high ratio of inflammatory omega-6.

SOY OIL

CORN OIL

CANOLA OIL

OLIVE OIL

OMEGA-3:OMEGA-6 RATIO IN SPECIALTY OILS BORAGE

SACHA INCHI

SAHIFLOWER FLAX

Chia Oil is the most effective way to rebalance the omega-3 to omega-6 ratio in the body

PERILLA

HEMP

CHIA

Chia Oil and Health: What The Science Says Scientific Evidence

How do chia’s oil impressive nutritional stats translate to human health benefits? The omega-3s and phytochemicals in this little grain are thought to offer significant benefits in helping protect against a host of diseases.

OMEGA-3S, PHYTOCHEMICALS, ANTIOXIDANTS

Much of chia oil's anti-inflammatory, disease-fighting activity is owed to alpha-linolenic acids (ALAs), those essential plant-based omega-3 fatty acids. The fat in chia seeds consists of more than 63% omega-3s, which far exceeds other plant-based omega-3 sources such as hemp and flaxseed. Chia oil also boasts a highly favorable ratio of anti-inflammatory omega-3 to pro-inflammatory omega-6 fatty acids1

ANTI-INFLAMMATORY BENEFITS FOR CHRONIC DISEASE PREVENTION

Chia oil comes packaged with a wide variety of anti-inflammatory compounds that may help reduce the risk for chronic diseases where inflammation has been identified as an important risk factor. Health conditions that have been shown to be associated with increased inflammation include, but may not be limited to:

• Diabetes and metabolic disorders

• Heart disease

• High cholesterol

• High blood pressure

• Memory-related disorders including dementia

• Obesity

• Arthritis and joint pain

• Skin-related conditions like psoriasis

There’s also a suite of potent phytochemicals to consider. Together, these compounds help thwart and prevent oxidative damage by activating anti-inflammatory activity

and simultaneously suppressing the production of pro-inflammatory substances 2,3 .

Worth noting is the fact that consumption of ALAenriched sources of omega-3 fatty acids can directly and significantly increase circulating levels of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) 4 , the omega-3 fatty acids that have historically received more attention for heart and brain health. In other words, consumers don't necessarily need to turn to seafood sources of omega-3s such as salmon or fish oil capsules. EPA and DHA can be effectively converted from plant-based ALA omega-3 sources such as chia oil.

As if that wasn't enough, let's not forget chia's copious antioxidant compounds. The oil's potent phytochemicals are tied to decreases in reactive oxygen species and reducing inflammatory processes that may slow or thwart the development of disease.

NEUROPROTECTIVE BENEFITS

It's fair to say that fatty acids such as omega-3 ALAs support the brain's ability to fire at maximum capacity. ALA omega-3s are a key component of the brain's cell membranes, allowing them to remain nimble and flexible5 . This increased neuroplasticity supports optimal neurotransmitter signaling, resulting in more effective chemical communication between the brain's neurons 6 .

The effects of this optimized brain functioning are potentially far-reaching. Animal studies suggest that consuming ALA can increase brain levels of DHA, which may reverse memory impairment for those with Alzheimer's disease7. ALA may also exert protective effects during seizures by reducing neuron loss during an episodic event 8 . Limited research has shown, too, that treatment with ALA after traumatic spinal cord injury may reduce cell death, in turn reducing the potential effects of central nervous system injuries 9 .

Psychiatric disorders may benefit from increased ALA consumption as well. Both attention deficit hyperactivity disorder and depression are associated with decreased levels of omega-3 fatty acids10 . Though more research is needed to understand the connection between psychiatric disorders and ALA, these findings suggest that omega-3 supplementation could play a valuable role in mental health.

PRENATAL, PEDIATRIC, AND MATERNAL HEALTH

Omega-3 fatty acids have long been known to play a key role in brain and eye development and function, both in utero and in early childhood. These essential fats are constituents of the phospholipids in cell membranes, and concentrations of omega-3s in the brain and retina are particularly high11

Omega-3s are transferred to the fetus during pregnancy via the placenta, and through breast milk for as long as a mother chooses to nurse. During both stages, omega-3s accumulate in the fetal and infant brain and retina at the expense of the mother. During pregnancy and throughout breastfeeding, mothers can consume adequate amounts of dietary omega-3s to ensure a steady fetal/infant supply of omega-3s without depleting their own vital stores12 .

Historically, much of the focus had been specifically on marine-based omega-3 sources such as DHA and EPA. Now, we know that a healthy pregnancy needn't necessarily hinge on fish or fish oil consumption alone. ALA sources of omega-3s such as chia can also support brain development during the prenatal period, and in fact, it's recommended that pregnant and breastfeeding women consume both DHA and ALA omega-3s. What's more, as a precursor to DHA13 , ALA omega-3 intake can actually drive up levels of DHA and EPA. Research shows that chia oil consumption during pregnancy and breastfeeding increases the content of ALA (76%) and EPA (57%) in erythrocyte phospholipids and the content of ALA (60%) and DHA (50%) in breast milk14 .

Concentrations of Omega-3: About

Ensuring an adequate supply of ALA and DHA omega-3s isn't just important for the developing fetus, and later, the growing infant. Crucially, omega-3s may offer protection against postpartum depression. A recent trial found that women who take 5 g of omega-3s daily at the end of pregnancy and at the onset of breastfeeding have a greater chance of alleviating some of the symptoms related postpartum depression15,16

CARDIOVASCULAR HEALTH

Omega-3 fatty acids act by modifying the mechanisms related to endothelial dysfunction, platelet aggregation, and atherosclerosis. They inhibit the activity of cyclooxygenase (responsible for the production of prostaglandins), and decrease the synthesis of inflammatory cytokines and the activity of the parasympathetic nervous system. These actions help reduce the risk of vascular events and hypertension, among other conditions. In addition, omega-3 is an anti-inflammatory agent that has been highlighted as an important factor in helping to prevent and control coronary heart disease.

Chia seed is an excellent source of omega-3s, fiber, and phytochemicals, among other important nutrients for cardiovascular health. Chia oil is a concentrated source of omega-3 fats and phytochemicals, tastes good and is easy to consume and use, both in cooking and in nutritional health and therapeutic supplements.

The reviewed literature provides the biological basis to explain the cardiovascular benefits of ALA consumption.17,18,19

A higher intake of ALA reduces the risk of ischemic heart disease (also called coronary heart disease) and is significantly associated with a lower risk of CVD and CHD mortality.

Evidence suggests that ALA intake reduces the risk of ventricular arrhythmia by more than 25%.

ALA supplementation has been shown to help lower total cholesterol, LDL cholesterol, and triglycerides, and increase HDL cholesterol.

Several investigations have shown the beneficial effects of ALA administered alone or as a component of food in lowering blood pressure.

Epidemiological evidence has shown that higher dietary ALA is associated with lower inflammation, as measured by inflammatory biomarkers.

Higher ALA intake has been shown to be associated with decreased intima-media thickness (IMT), inferior carotid plaque, and coronary artery plaque.

New Science Available on ALA Conversion to Long-Chain Omega-3 EFAs

New science clarifying the regulation in animals and humans of the EPA & DHA endogenous biosynthesis pathway unveils evidence of no DHA retroconversion and higher conversion of ALA into EPA and DHA. 23

Dr Richard Bazinet is a researcher at the University of Toronto Nutritional Sciences and Chair of Canada Brain Lipid Metabolism. He is president of ISSFAL (International Society for Study of Fatty Acids and Lipids). He is one of the world's leading researchers in the regulation and role of brain lipid metabolism and, as such, a pioneer in new discoveries on the LC PUFA biosynthesis pathway and its regulation in humans and in the brain particularly. He is currently taking a kinetic and biochemical approach to studying the mechanisms by which dietary polyunsaturated fatty acids regulate the metabolism of docosahexaenoic fatty acid.

KEY POINTS

• Dr Richard Bazinet from the University of Toronto (and ISSFAL President) is a well-known and a pioneer researcher on brain lipid metabolism. As such, he and his group work to improve our understanding of the EPA DHA endogenous biosynthesis pathway and its regulation.

• This research group has been a pioneer in applying high-precision measurements on differences in natural isotope ratios in fatty acids (CSIA, compound-specific isotope analysis). 20,21,23,25,27

• The new science allows to accurately determine the ratios of internal biosynthesis of any LC PUFA in mice and humans from its precursors, versus its secretion to target tissues (turnover). 20,21,23,25,27

• One of his major data-based findings revisits a famous previous dogma: there is no retro conversion of DHA into EPA. 23,27

• Dr Brenna, a lipid science world leader researcher, has validated Dr Bazinet’s new science. 28

• Another key finding based on this science is that ALA is converted to EPA and DHA much more than previously established, even in the presence of LA. Synthesis / secretion rates of DHA from ALA in mice and humans are high. 20,22,24,26,29

• It is also proven, with the same method, that when DHA is the only supplied source, high-quality ALA is needed to further rescue EPA functional levels. 20,24,25,26,29

• Benexia’s essential ALA is an extra virgin natural nutritional (lipid) oil, non-GMO, minimally processed.

• It has the higher ALA and minimal LA profile found in nature. Also, it has naturally occurring bioactive compounds [polyphenols (caffeic acid, p-coumaric acid), tocopherols, phytosterols) that make it uncommonly stable.

• It is the ideal source to optimize the functional lipid profile of any DHA or EPA DHA source, based on the new evidence.

• It is a natural, clean oil with minimal, if any, detectable content of mineral oils (MOAH).

• Benexia’s essential ALA oil is a predictable, competitive, and sustainable source of LC PUFA Omega-3 with fully integrated traceability from crop seed to drum.

• Benexia is world leader in Chia oil with more than 20 years of industry and mainstream international market excellence.

Recent research conducted by the Department of Nutritional Sciences at the University of Toronto in mice shows that dietary alpha-linolenic acid (ALA), an essential omega-3 fatty acid, appears necessary for the efficient synthesis of circulating levels of eicosapentaenoic acid (EPA), which are critical for the regular maintenance of (docosahexaenoic acid) DHA in the body, and particularly brain tissue. 20

Using specialized carbon isotope ratio mass spectroscopy, preliminary animal evidence shows that plant-based dietary ALA sources are converted to circulating plasma DHA at relatively efficient turnover rates compared to an oil-based fish source or oil-based algae DHA. 20,21,25 Individuals consuming pre-formed DHA demonstrated decreased circulating EPA levels from a baseline, while those who consumed plant-based sources of ALA + DHA maintained circulating EPA from baseline. 20

Previously, the same researchers had demonstrated estimates of whole-body synthesis-secretion rates of esterified long-chain n-3 PUFA from circulating unesterified ALA in human subjects. 22

The University of Toronto’s research in animals and humans demonstrates that DHA synthesis rates may be higher than previously thought, even in the presence of LNA, and lays the groundwork to demystify the presumed "inefficient" synthesis of ALA to DHA. 24

These findings also support other research showing that plant-based omega-3 sources are necessary to maintain metabolic priority and flow of EPA metabolites (E-series resolvins) to critical tissues when needed. They further reveal, contrary to what was believed, that EPA cannot be adequately formed from dietary DHA by retro-conversion, and that circulating levels of EPA and DHA are regulated at another level than interconversion between EPA and DHA. 23,27,28

Therefore, it is advisable to maintain an adequate balance of omega-3 ALA from the richest plant sources and DHA from plant or marine sources available in the diet to promote a high accumulation of EPA. 20

Plant-based omega-3 fatty acids will be naturally and efficiently biosynthesized and accumulated as circulating supplies of EPA, which will then be dynamically deployed into tissue forms of DHA as needed. 29

Emerging science suggests the human body can successfully manage a dynamically changing and continually optimized endogenous flow of omega-3s from plant sources. It is generally understood that the DHA requirement for a healthy human brain is about 3.8 mg/day. This level can be easily achieved through the biosynthesis of plant-based ALA, even at synthesis as low as 1% based on current average intake levels. 26

Regulatory Status of Chia Oil

Health, structure-function, and functional health claims

Benexia® Xia oil is an exceptionally rich nutritional ingredient. Contains >63% of Alpha-Linolenic fatty acid and critical bioactive substances: Naturally high in antioxidants, tocopherols, and phytosterols. Benexia® Xia Oil is gluten-free, 100% pure and natural, free of contaminants, vegetarian, Kosher, and Halal.

A dietary supplement having 1 gram of Xia Oil (over 600 mg of Alpha-Linolenic acid) can claim: “High in Omega-3 ALA”, according to Omega-3 Nutrient Content Claim regulation.

USA – FUNCTION STRUCTURE CLAIMS

Regulatory:

Federal Register - January 6, 2000 (page 1000 to 1050) Food and Drug Administration Final Rule under Food Labelling – 21 CFR Part 101.93

Statements Made for Dietary Supplements Concerning the Effect of the Product on the Structure or Function of the Body.

The following are examples of structure/function claims regarding ALA Omega-3 and heart health that have been reviewed and confirmed to comply with dietary supplement regulations for use on dietary supplement labels marketed in the U.S.:

• ALA Omega-3 improves heart health

• ALA Omega-3 promotes cardiovascular health

• ALA Omega-3 supports heart health

Conditions and possible restrictions of use:

Dietary supplement manufacturers, however, are required to notify the FDA of such labelling.

EUROPE –HEALTH CLAIM

Regulatory:

EFSA opinion reference 2009;7(9):1252, 2011;9(6):2203; according to Commission Regulation (EU) 432/2012 of 16/05/2012.

Authorised function health claims related to alpha-linolenic acid and maintenance of normal blood cholesterol concentrations:

“ALA contributes to the maintenance of normal blood cholesterol levels."

Conditions and possible restrictions of use:

The claim may be used only for food which is at least a source of ALA as referred to in the claim SOURCE OF OMEGA 3 FATTY ACIDS as listed in the Annex to Regulation (EC) No 1924/2006. Information shall be given to the consumer that the beneficial effect is obtained with a daily intake of 2 g of ALA.

JAPAN – FUNCTIONAL HEALTH CLAIM

Regulatory: Consumer Affairs Agency, Government of Japan. Health function(s) Claim to be labelled on the consumer products:

“Chia seed oil contains alpha-linolenic acid. It is reported that alpha-linolenic acid is effective to lower the blood pressure of those whose blood pressure is slightly higher than normal range”.

Conditions and possible restrictions of use: The amount of functional ingredient per recommended daily intake is 2.6 grams. The Chia Oil must be manufactured by Functional Products Trading Arica S.A, Benexia ́s institutional company name.

Xia Oil APPLICATIONS CONCEPTS

Dietary Supplements: Chia Oil Soft Gel Caps

Fish EPA/DHA + Chia Oil ALA

COMPOSITION

per 2 capsules

Benexia® Chia Oil 1000 mg

Fish Oil 1000 mg

Supplement Facts

Serving Size: 2 Softgel Capsules

Calories 18

Total Fat 2g 4% Sat Fat 0.3g 1%

Total Omega-3 Fatty Acid 1150 mg

ALA (alpha-linolenic acid) 630 mg

DHA (docosahexaenoic) 200mg

EPA (eicosapentaenoic acid) 320 mg

* Percent Daily Values are based on a 2,000 calorie diet.

† % Daily Valu not established.

STRUCTURE/FUNCTION CLAIMS* | USA

ALA-DHA

Scientific evidence demonstrates that diets that includes omega-3 fatty acids (DHA and ALA) may:

• Strengthens heart health for cardiovascular support.

• Supports immune system.

• Improves brain development during pregnancy and lactation.

• Promotes healthy skin, hair and nails.

HEALTH CLAIMS | EU

Omega-3 ALA

Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels.

Recommended daily intake: 2g ALA.

Omega-3 DHA

Docosahexaenoic acid (DHA) maternal intake contributes to the normal brain development and normal development of the eye of the foetus and breastfed infants. The beneficial effect for pregnant and lactanting women is obtained with a daily intake of 200mg of DHA in addition to the recommended daily intake for omega-3 fatty acids for adults, i.e.: 250mg DHA and eicosapentaenoic acid (EPA).

KEY ADVANTAGES

• 100% sustainable sources of omega-3.

• Allergen free ingredients.

• No fishy flavor or reflux.

• 3 health claims: ALA and cholesterol, DHA and brain and vision.

TARGET

• Maternity.

• Brain and vision health.

• Cardio - cholesterol.

• Balanced nutrition.

100% Chia Oil

100% Plant-based ALA: Omega-3 metabolism booster 20,22

COMPOSITION

per 2 capsules

Benexia® Chia Oil 2000 mg

Supplement Facts

Serving Size: 2 Softgel Capsules

Amount per Serving % Daily Value*

Calories 18

Total Fat 2g 4% Sat Fat 0.3g 1%

Total Omega-3 Fatty Acid

ALA (alpha-linolenic acid) 1260 mg †

* Percent Daily Values are based on a 2,000 calorie diet. † % Daily Valu not established.

STRUCTURE/FUNCTION CLAIMS* | USA

• Support heart and cardiovascular health.

• Reduce inflammation.

• Supports immune system.

HEALTH CLAIMS | EU Omega-3 ALA

Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels.

Recommended daily intake: 2g ALA.

KEY ADVANTAGES

• 100% vegetal

• 63% of plant-based omega-3.

• High in antioxidants, polyphenols, tocopherols and phytosterols.

• No fishy taste or reflux.

TARGET

• Cardio - cholesterol.

• Cardio - hypertension/circulation.

• Balanced nutrition.

Algae DHA + Chia Oil ALA

ALA + DHA, fully plant-based Omega-3s: A full PUFAs offer 20,25,26

COMPOSITION

per 2 capsules

Benexia® Chia Oil

Microalgae Oil

Supplement Facts

Serving Size: 2 Softgel Capsules

1280 mg

720 mg

Amount per Serving % Daily Value*

Calories 18

Total Fat 2g 4%

Sat Fat 0.3g 1%

Total Omega-3 Fatty Acid 1056 mg † ALA (alpha-linolenic acid) 806 mg † DHA (docosahexaenoic) 250mg †

* Percent Daily Values are based on a 2,000 calorie diet.

† % Daily Valu not established.

STRUCTURE/FUNCTION CLAIMS* | USA

ALA-DHA

Scientific evidence demonstrates that diets that includes omega-3 fatty acids (DHA and ALA) may:

• Strengthens heart health for cardiovascular support.

• Supports immune system.

• Improves brain development during pregnancy and lactation.

• Promotes healthy skin, hair and nails.

HEALTH CLAIMS | EU

Omega-3 ALA

Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels.

Recommended daily intake: 2g ALA.

Omega-3 DHA

Docosahexaenoic acid (DHA) maternal intake contributes to the normal brain development and normal development of the eye of the foetus and breastfed infants. The beneficial effect for pregnant and lactanting women is obtained with a daily intake of 200mg of DHA in addition to the recommended daily intake for omega-3 fatty acids for adults, i.e.: 250mg DHA and eicosapentaenoic acid (EPA).

KEY ADVANTAGES

• 100% vegetal and sustainable sources of omega-3.

• Allergen free ingredients.

• No fishy flavor or reflux.

• 3 health claims: ALA and cholesterol, DHA and brain and vision.

TARGET

• Maternity.

• Brain and vision health.

• Cardio - cholesterol.

• Balanced nutrition.

Chia Oil as a Food Dietary Supplement: Simply add it to your food!

Natural, plant-based

Essential for your health

Your daily Omega-3

63% omega-3 ALA

Leet your food be your medicine

Take a spoon per day

Light and delicate nutty taste

Ideal for enhancing meals, smoothies, beverages, or soups.

Sustainable food from regenerative agriculture

Nutritional Data Sheet

PRODUCT

Benexia® Xia Oil

REFERENCE CODE

OIL

OILO

DATE

June 2023

1: As this is a natural product, the values reported as typical may vary.

2: Calorie calculation (common conversion factors): In the US, use the 4-4-9 method, which assumes that each gram of protein contributes 4 calories to the caloric total, each gram of carbohydrates contributes 4 calories (less the amount of non-digestible carbohydrates), and each gram of fat contributes 9 calories (FDA).

3: In Canada and in the European Union, use the 4-4-9 adjusted for fiber. A value of 2 calories (8 kJ) per gram should be used for the dietary fiber portion of the fiber source.

Technical Data Sheet

PRODUCT

Benexia® Xia OIl

REFERENCE CODE

XIA OIL

DATE May 2023

DESCRIPTION

Benexia® Xia Oil is a golden-colored, transparent, and brilliant oil obtained through a proprietary premium technology, ensuring the most natural cold-press extraction of plant-based omega-3 from chia seed (Salvia hispanica L.).

INGREDIENTS

100 % chia oil

FORMAT AND PACKAGING MATERIAL

190 Kg enamelled drum

Packed under modified atmosphera (MA), replacing oxygen by nitrogen.

BEST BEFORE DATE AND STORAGE

24 months, stored in a cool dry place in original unopened package.

Recommended storage conditions: Temperature <20 oC and <60 % of relative humidity. Once opened, it is recommended to consume the whole drum or refill with nitrogen before sealing.

CERTIFICATIONS

FSSC 22000

Halal and Kosher

QUALITY ASSURANCE

Additives: Free GMO: Free

Allergens: According to allergen assessment.

Contaminants: Comply with regulation.

Suitable diets: Gluten free, vegetarian, vegan, keto, and low carb.

APPLICATIONS

Food, beverage, and nutraceutical ingredient.

REGULATION

Chia oil has been approved as Novel Food (Commission Decision 2014/890/EU).

Custom Tariff Code: 15.15.9090

Origin: Chile.

Microbiological

* Or equivalent method ** At the end of the shelf-life period, if it has been stored according to instructions. The typical value at the date of manufacture is <2

O2/Kg. 1: Analysed per lot production 2: Analysed per yearly productions

Xia Oil Organic

Technical Data Sheet

PRODUCT

Benexia® Xia Oil Organic

REFERENCE CODE

XIA OIL O

DATE

May 2023

DESCRIPTION

Benexia® Xia Oil Organic is a golden-colored, transparent, and brilliant oil obtained through a proprietary premium technology, ensuring the most natural cold-press extraction of plant-based omega-3 from chia seed (Salvia hispanica L.).

INGREDIENTS

100 % chia oil organic.

FORMAT AND PACKAGING MATERIAL

190 Kg enamelled drum

Packed under modified atmosphera (MA), replacing oxygen by nitrogen.

BEST BEFORE DATE AND STORAGE

24 months, stored in a cool dry place in original unopened package.

Recommended storage conditions: Temperature <20 oC and <60 % of relative humidity. Once opened, it is recommended to consume the whole drum or refill with nitrogen before sealing.

CERTIFICATIONS

FSSC 22000

Halal and Kosher

Organic under EU regulation. Organic quality NOP/USDA - COR equiv.

QUALITY ASSURANCE

Additives: Free GMO: Free

Allergens: According to allergen assessment.

Contaminants: Comply with regulation. Suitable diets: Gluten free, vegetarian, vegan, keto, and low carb.

APPLICATIONS

Food, beverage, and nutraceutical ingredient.

REGULATION

Chia oil has been approved as Novel Food (Commission Decision 2014/890/EU).

Custom Tariff Code: 15.15.9090

Origin: Chile.

Microbiological

* Or equivalent method ** At the end of the shelf-life period, if it has been stored according to instructions. The typical value at the date of manufacture is <2 meq O2/Kg. 1: Analysed per lot production 2: Analysed per yearly productions

References

1. Djuricic, I., & Calder, P. C. (2021). Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Nutrients, 13(7), 2421. https://doi.org/10.3390/nu13072421

2. Zhao, G., Etherton, T. D., Martin, K. R., Gillies, P. J., West, S. G., & Kris-Etherton, P. M. (2007). Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. The American journal of clinical nutrition, 85(2), 385–391. https://doi. org/10.1093/ajcn/85.2.385

3. Rallidis, L. S., Paschos, G., Liakos, G. K., Velissaridou, A. H., Anastasiadis, G., & Zampelas, A. (2003). Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis, 167(2), 237–242. https://doi.org/10.1016/s0021-9150(02)00427-6

4. Valenzuela, R., Bascuñán, K., Chamorro, R., Barrera, C., Sandoval, J., Puigrredon, C., Parraguez, G., Orellana, P., Gonzalez, V., & Valenzuela, A. (2015). Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. Nutrients, 7(8), 6405–6424. https://doi.org/10.3390/nu7085289

5. Vuksan, V., Whitham, D., Sievenpiper, J. L., Jenkins, A. L., Rogovik, A. L., Bazinet, R. P., Vidgen, E., & Hanna, A. (2007). Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trial. Diabetes care, 30(11), 2804–2810. https://doi.org/10.2337/dc07-1144

6. Basiouni, S., Stöckel, K., Fuhrmann, H., & Schumann, J. (2012). Polyunsaturated fatty acid supplements modulate mast cell membrane microdomain composition. Cellular immunology, 275(1-2), 42–46. https://doi.org/10.1016/j. cellimm.2012.03.004

7. Calon, F., Lim, G. P., Morihara, T., Yang, F., Ubeda, O., Salem, N., Jr, Frautschy, S. A., & Cole, G. M. (2005). Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. The European journal of neuroscience, 22(3), 617–626. https://doi.org/10.1111/j.1460-9568.2005.04253.x

8. Guizy, M., David, M., Arias, C., Zhang, L., Cofán, M., Ruiz-Gutiérrez, V., Ros, E., Lillo, M. P., Martens, J. R., & Valenzuela, C. (2008). Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid. Journal of molecular and cellular cardiology, 44(2), 323–335. https://doi.org/10.1016/j. yjmcc.2007.11.004

9. Lang-Lazdunski, L., Blondeau, N., Jarretou, G., Lazdunski, M., & Heurteaux, C. (2003).Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. Journal of vascular surgery, 38(3), 564–575. https:// doi.org/10.1016/s0741-5214(03)00473-7

10. Young, G., & Conquer, J. (2005). Omega-3 fatty acids and neuropsychiatric disorders.Reproduction, nutrition, development, 45(1), 1–28. https://doi.org/10.1051/rnd:2005001

11. Lauritzen, L., Hansen, H. S., Jørgensen, M. H., & Michaelsen, K. F. (2001). The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Progress in lipid research, 40(1-2), 1–94. https://doi.org/10.1016/s0163-7827(00)00017-5

12. Coletta, J. M., Bell, S. J., & Roman, A. S. (2010). Omega-3 Fatty acids and pregnancy. Reviews in obstetrics & gynecology, 3(4), 163–171.

13. Greenberg, J. A., Bell, S. J., & Ausdal, W. V. (2008). Omega-3 Fatty Acid supplementation during pregnancy. Reviews in obstetrics & gynecology, 1(4), 162–169.

14. Valenzuela, R., Bascuñán, K., Chamorro, R., Barrera, C., Sandoval, J., Puigrredon, C., Parraguez, G., Orellana, P., Gonzalez, V., & Valenzuela, A. (2015). Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who

Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. Nutrients, 7(8), 6405–6424. https://doi.org/10.3390/nu7085289

15. Su, K. P., Huang, S. Y., Chiu, T. H., Huang, K. C., Huang, C. L., Chang, H. C., & Pariante, C. M. (2008). Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry, 69(4), 644–651. https://doi.org/10.4088/jcp.v69n0418

16. Hsu, M. C., Tung, C. Y., & Chen, H. E. (2018). Omega-3 polyunsaturated fatty acid supplementation in prevention and treatment of maternal depression: Putative mechanism and recommendation. Journal of affective disorders, 238, 47–61. https://doi.org/10.1016/j.jad.2018.05.018

17. Naghshi S, et al. Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and doseresponse meta-analysis of cohort studies BMJ 2021; 375:n2213.

18. Abdelhamid AS, et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2020, Issue 3. Art. No.: CD003177.

19. Aleix Sala-Vila, Jennifer Fleming, Penny Kris-Etherton, Emilio Ros, Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition, Advances in Nutrition, 2022;, nmac016, https://doi.org/10.1093/advances/nmac016

20. Metherel AH, Klievik BJ, Cisbani G, Smith ME, Cumberford G, Bazinet RP. Blood and tissue docosahexaenoic acid (DHA, 22:6n-3) turnover rates from Ahiflower® oil are not different than from DHA ethyl ester oil in a diet switch mouse model. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Jan;1869(1):159422.

21. Lacombe R et al (2020) Turnover of brain DHA in mice is accurately determined by tracer-free natural abundance carbon isotope ratio analysis. J Lipid Res Jan;61(1):116-126.

22. Lin, Y.-H., Hibbeln, J.R., Domenichiello, A.F., Ramsden, C.E., Salem, N.M., Chen, C.T., Jin, H., Courville, A.B., Majchrzak-Hong, S.F., Rapoport, S.I., Bazinet, R.P. and Miller, B.V., III (2018), Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State. Lipids, 53: 547-558.

23. Metherel A, Bazinet R (2019) Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion. Prog Lipid Res Oct; 76:101008.

24. Anthony F. Domenichiello, Alex P. Kitson, Chuck T. Chen, Marc-Olivier Trépanier, P. Mark Stavro, Richard P. Bazinet, The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats, The Journal of Nutritional Biochemistry, Volume 30, 2016, Pages 167-176.

25. Metherel AH, Irfan M, Chouinard-Watkins R, Trépanier MO, Stark KD, Bazinet RP. DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long-Evans Rats. J Nutr. 2019 Apr 1;149(4):586-595.

26. Domenichiello A, et al (2015) Is docosahexaenoic acid synthesis from a-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research 59; 54-66

27. Metherel A, et al (2019) Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a randomized control trial. Am J Clin Nutr 110(4) 823-831.

28. J Thomas Brenna. DHA retroconversion revisited: dietary DHA spares endogenous EPA. Am J Clin Nutr 2019;110:789–790.

29. Metherel AH, Valenzuela R, Cisbani G, Bazinet RP. Dietary alpha-linolenic acid is necessary for the increase in eicosapentaenoic acid upon docosahexaenoic acid intake. 2021 ISSFAL Congress, May 10 - 14, 2021.

Benexia Ingredients

BENEXIA® BLACK AND WHITE CHIA SEED

BCS R Benexia® Black Chia Seed Raw.

BCS O R Benexia® Black Chia Seed Organic Raw.

BCS LM Benexia® Black Chia Seed Low Moisture, pasteurized, RTE.

BCS O LM Benexia® Black Chia Seed Organic Low Moisture, pasteurized, RTE.

WCS R Benexia® White Chia Seed Raw.

WCS O R Benexia® White Chia Seed Raw.

WCS LM Benexia® White Chia Seed Low Moisture, pasteurized, RTE.

WCS O LM Benexia® White Chia Seed Organic Low Moisture, pasteurized, RTE.

BENEXIA® XIA OIL: FATS INGREDIENTS

Benexia® Xia Oil is chia oil, obtained through a proprietary premium technology, for a natural cold-press extraction of the chia seed (Salvia hispanica L.). It contains 63% of omega-3.

XIA OIL Benexia® Xia Oil offers great opportunities to develop products in foods and beverage. We offer formulations for a broad range of food applications in fats, oils blends, flavored oils, vegetable spreads, bakery, dairy, juices, condiments, and specialty retail oils.

XIA OIL O Benexia® Xia Oil Organic.

BENEXIA® XIA POWDERS: PROTEIN AND FIBER SOURCES

Xia Powder 125 LM is a fine and dispersible chia protein powder, concentrated up to 42%. Xia Powder 435 LM is a fine chia fiber powder, concentrated up to 56% and with more protein than chia seed. Both are manufactured from the partially defatted Benexia® Chia, obtained through MicroTech® technology.

XIA POWDER 125 W LM Xia Powder 125 White Low Moisture.

XIA POWDER 125 W O LM Xia Powder 125 White Organic Low Moisture.

XIA POWDER 435 W LM Xia Powder 435 White Low Moisture.

XIA POWDER 435 W O LM Xia Powder 435 White Organic Low Moisture.

BENEXIA® PREMIXES

This line offers this amazing nutrition found in chia seed in high-fiber, high-protein bakery premixes. These premixes check all the boxes: texture, taste, simplicity and fortification. All the premixes include our ingredient Benexia® Xia Powder 435 W LM.

KETO/LOW-CARB

GLUTEN-FREE

GLUTEN-FREE AND KETO/LOW-CARB HIGH FIBER

W stands for white, ground from white chia seeds. LM means Low Moisture. The ingredient is processed through Microtech® technology.

O indicates products from controlled organic cultivation.

Benexia, a leader in the industry

All Benexia® Ingredients are naturally processed, cleanlabel, gluten-free, and come from sustainable agriculture.

Benexia is a fully vertically integrated company (from agricultural production, extraction and concentration processes, ingredients development, and distribution), from chia agricultural production plant to the final ingredients and solutions.

Benexia guarantees traceability from the fields to your facility and offers certified quality (GAP, GMP-HACCP, and FSSC 22000), Halal, and Kosher.

Our team, the best customer service

We are a group of passionate people fully devoted to our customers, with a great sense of service and love for health and well-being. We offer support in formulation, nutrition, scientific and regulatory matters, with the best experts to assist your needs.

Contact us for samples, application sheets and more information at info@benexia.com