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Chia Ingredients: Benexia® Xia Oil

XIA OIL, A NEW NATURAL SUSTAINABLE SOURCE OF OMEGA-3

An Ancient Superfood for the 21st Century The Power of Chia The seeds of change may start small, but in the right environment, they grow mighty. That can certainly be said of the chia plant, whose minuscule seed grains nourished ancient civilizations for centuries - and has, in recent decades, experienced a revitalization as a superfood ideal for meeting the needs of modern consumers. Most call Chia a seed, though it’s technically a grain. Regardless of how consumers categorize it, the tiny black or white orbs far surpass their seed or grain counterparts when it comes to nutrition: Chia brings together protein, omega-3 fatty acids, fiber, antioxidants, and an array

40%

of minerals, all in a package no bigger than a pinhead.

of Dietary Fiber

An ancient food with the highest omega-3 content

22%

found in nature: with unsuspected health benefits, chia

of Proteins

is an amazing sustainable source of essential nutrients.

20%

A unique nutritional profile has enabled for chia to sustain civilizations such as the Aztecs and the Mayans. Today, a mounting body of evidence shows that the grain has the potential to aid in addressing some of our most pressing health concerns, including heart disease, diabetes, inflammation, and neurocognitive and neurodegenerative conditions. Chia’s nutritional components have also proven integral to fetal and child development, positioning it to support the health of coming

of Omega-3

of Omega-6

1:4

generations through pre- and postnatal nutrition.

omega-6:omega-3 ratio

The versatile grains can be enjoyed whole (both raw or soaked) or cold-pressed into a nutrient-dense oil, while the leftover matter can be ground in a fiber- and protein-rich flour.

Minerals

Calcium, phosphorus, magnesium, potassium The fact that chia is plant-based, free of gluten, zero net carbs, and high in protein has also made it popular among multiple dietary patterns, including vegan, lowcarb/keto, and gluten-free diets.

Vitamins Phytonutrients

High levels of antioxidants, tocopherols, and plant sterols

AN ANCIENT SUPERFOOD FOR THE 21ST CENTURY

A Highly Sustainable Food Source Chia, too, is a food that supports the health of the planet. Requiring few resources to thrive in its native environment, the crop supports humanity’s need for increased sustainability, reduced water usage, and fewer greenhouse gas emissions in our global food supply.

CLEAN, NO-WASTE PRODUCTION METHODS Fresh from the field, Benexia's newly-harvested chia seeds are processed in highly sustainable ways. Seeds are cleaned and separated using physical processes such as

Chia is, by its very nature, a highly sustainable crop. Grown

airflow and density-based separation methods, yielding a

in its native South America, where it evolved to thrive—it’s

final seed product that's 99.95% pure.

the right plant for the right place—and can be grown with minimal additional resources. Benexia, a fully integrated company specializing in the production, processing, and commercialization of chia and chia-based ingredients, has built on these inherent qualities to yield an eco-friendly farming production process that gives back to the local environment, local communities, and the planet at large. Ultimately, chia is a food people can feel good about.

From there, all parts of the seeds are used to ensure that nothing is lost - and no resources are wasted. After the seeds are cleaned, they are pasteurized with a specialized, organically certified process that uses no solvents, chemicals, or water, while the omega-3 rich chia oil is extracted from the seeds via a single cold pressing to retain maximum nutrition capacity. The oil is cleaned and purified through a filter, that, again, requires no chemicals or solvents.

99.95%

Once the oil is extracted from the seeds, the leftover fibrous matter is dried and milled to separate the fiber

the level of purity of chia seeds grown,

from the protein. The powdered chia fiber and protein,

cleaned and processed by Benexia

now a fine flour, can be incorporated into baked goods,

After a couple of years of carefully monitored harvests, chia fields are left to rest crop-free for 1-2 years during

pizza crusts, breads, and more, as a source of zero-waste, functional nutrition.

which grasses are planted and animals can graze. Once

CORPORATE RESPONSIBILITY

the land has been fully replenished and the soil’s inherent

Considering Benexia's commitment to the planet, it may

nutrient composition is again optimal, a new crop is planted. These crop rotation practices support healthier soil, which in turn yields greater crop resilience as well as more reliable local economic activity.

come as no surprise that, since its founding in 2005, the company is equally dedicated to supporting the welfare of its local communities. Benexia is aligned with the United Nations’ Sustainable Development goals and is on track to complete its B Corporation certification by 2024.

Chia’s nutrition, sustainability, and versatility make it a highly appealing option for consumers and food manufacturers.

As a vertically integrated company, 50% of Benexia's partner shareholders are chia seed farmers. This guarantees fair pricing and technical support within the company's supply chain as well as full traceability of their ingredients.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Benexia® Xia Oil Natural and Virgin, with >60% of Essential Omega-3 Cold-pressed from fresh, high-quality, low-moisture chia seeds, chia oil is a pure, extra virgin, unrefined oil made without chemical solvents or diluents. Benexia's careful processing preserves chia's liposoluble nutrients and bioactive components, resulting in an oil with the highest concentration of essential omega-3 fatty acids among plant-based oils, with an excellent oxidative stablility and superior organoleptic properties.

With 63% of chia oil’s total fat consisting of omega-3 ALA, just one teaspoon provides twice

FATTY ACIDS PROFILE SATURATED: 10.5% Saturated

% Metil Ester

g/100g

mg/100g

C12:0 Lauric

0,000

C14:0 Tetradecanoic

0,021

21,081

C16:0 Palmitic

7,115

7,043

7.042,57

C18:0 Stearic

3,141

3,110

3.109,61

C20:0 Eicosanoic

0,272

0,269

269,15

C22:0 Docosanoic

0,043

0,042

42,04

C24:0 Tetracosanoic

0,089

0,088

88,49

Total

10,681

10,573

10.572,93

% Metil Ester

g/100g

mg/100g

MONOUNSATURATED: 7.2%

the recommended daily ALA intake,

Monounsaturated

qualifying as an “excellent source.”

C14:1

Tetradecaenoic

0,000

C16:1

Palmitoleic

0,036

0,035

35,230

C18:1

Oleic

7,195

7,122

7.122,35

C20:1n9 Eicosaenoic

0,137

0,135

135,23

C22:1n9 Erucic

0,000

C24:1n9 Tetracosaenoic

0,006

6,235

Total

7,374

7,299

7.299,04

g/100g

mg/100g

POLYUNSATURATED: 82.2% 63% Omega-3 ALA · 19% Omega-6 Polyunsaturated

% Metil Ester

C18:2n6 Linoleic

18,232

18,036

18.036,17

C18:3n3 Linolenic

63,640

63,004

63.003,82 26,813

C20:2n6 Eicosadienoic

0,027

C20:3n6 Eicosatrienoic

0,000

C20:3n3 Eicosatetrienoic

0,024

0,023

23,383

C20:4n6 Eicosatetraenoic

0,015

15,277

C20:5n3 Eicosapentaenoic

0,000

C22:5n3 Docosapentaenoic

0,007

6,655

C22:6n3 Docosahexaenoic

0,000

Total

81,945

81,112

81.112,12

BENEXIA® XIA OIL

Discovering Chia Oil´s Hidden Power: A nutritionally Essential Precursor Oil When considering the nutritional benefits of chia oil, it is

This way, chia oil supports the body's natural

not solely about omega-3 fatty acids. What makes chia oil

defense systems against everyday environmental

a one-of-a-kind seed oil is its diverse range of bioactive

stressors, exhibiting a remarkable protective effect for

compounds that are concentrated inside.

general well-being.

With the power to potentiate and amplify omega-3

In addition, these bioactive compounds contribute

physiological effects, this series of polyphenols,

to Benexia Chia Oil’s outstandingly high Oxygen

tocopherols and plant sterols are characterized by

Radical Absorbance Capacity (ORAC) and excellent

having an adjuvant role in balancing inflammation

Oxidative Stability.

responses, which, combined with ALA, bring remarkable health benefits.

CHIA’S BIOACTIVE COMPOUNDS

• • •

Supporting and promoting a healthy, balanced,

The latest scientific studies on lipid metabolism are re-considering the role of ALA in nutrition and health and offering a wide field of applications in lipid combinations for nutraceutical solutions. These combinations can help brands and consumers to expand and re-think their offer

inflammation response and simultaneously suppress

with more complete omega-3 profiles and functionalities.

the production of proinflammatory substances.

Chia oil is natural and extra virgin; therefore, it is free

Are tied to decreases in reactive oxygen species and

of MOAH. Also, its content in MOSH is very under the

supporting healthy cell function.

regulatory limits.

They modify the mechanisms related to endothelial dysfunction, platelet aggregation, and overall cardiovascular health.

•

They inhibit the activity of cyclooxygenase (responsible for the production of prostaglandins) and decrease the synthesis of inflammatory cytokines and the activity of the parasympathetic nervous system.

•

These actions help promote healthy cardiovascular function and maintain normal blood pressure already within a normal range.

MOSH stands for Mineral Oil-Saturated Hydrocarbons, which are a health concern. They are paraffin-like, open-chained, commonly branched hydrocarbons (e.g., alkanes) and naphthene-like cyclic hydrocarbons (cycloalkanes). MOSH accumulates in the liver and lymphoid system, causing inflammation. MOSH/POSH (sum) <5 mg/kg. The most likely cause of its presence in chia oil and the oils industry is transfer through the packaging material.

MOAH stands for Mineral Oil Aromatic Hydrocarbons.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

BIOACTIVE COMPOUNDS ANTIOXIDANTS

PHYTOSTEROLS

Polyphenols

Phytosterols

(mg/100g)

(ug/100g)

Betasitosterol

65.4

Caffeic Acid

23.71

Campesterol

14.3

p-Coumaric Acid

10.10

Avesterol

8.4

Stigmasterol

4.4

Other Sterols

7.5

Phenolic Acids

Vitamin E Tocopherols

(mg/kg)

Alpha-tocopherol

Gamma-tocopherol

500

Delta-tocopherol

Tocotrienols

<10

ORAC

>2500 μmol/TE

10%

82%

Polyunsaturated 19% Omega-6 Linolenic Acid 63% Omega-3 Alpha Linolenic Acid

Saturated 3% Stearic Acid 7% Palmitic Acid

Monounsaturated Tocopherols

7% Omega-9 Oleic Acid

Polyphenols Phytosterols

BENEXIA® XIA OIL

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Omega-3 to Omega-6 ratio in Benexia Chia Oil: balance your Omega’s Chronic inflammation has shown to be a risk factor for

like vegetable oils including soybean, sunflower, palm, and

major health conditions, including heart disease, diabetes,

canola. Omega-3 fats, like those found in chia oil, can help

and many others. The typical Western diet is too high in

establish a healthier omega-6 to omega-3 ratio overall,

pro-infammatory foods, among them omega-6 fat sources

creating a better balance to promote health1.

OMEGA-3

OMEGA-6

MONO

SATURATED FAT

OTHER

Grapeseed oil Avocado oil Refined soybean oil Sesame oil Refined high-oleic sunflower oil Refined canola oil Peanut oil Refined corn oil Palm oil Cottonseed oil

CHIA OIL - COLD-PRESSED Refined Sunflower oil Extra virgin olive oil Walnut oil Macadamia nut oil Almond oil Coconut oil Ghee (Clarified Butter) Lard Butter Virgin olive oil Flaxseed oil

Chia Oil is the most effective way to rebalance the omega-3 to omega-6 ratio in the body

BENEXIA® XIA OIL

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Scientific Evidence Chia Oil and Health: What The Science Says PRENATAL, PEDIATRIC, AND MATERNAL HEALTH As an essential precursor to DHA, ALA omega-3 intake can drive up levels of DHA and EPA. HUMAN STUDY: CHIA OIL SUPPLEMENTATION IN PREGNANT WOMEN In 2015, a study of 40 young and healthy pregnant women, age 22 -35 years, received from the third trimester of pregnancy until the first six months of nursing, either 12 g of chia oil daily for 9 months or placebo. The results of this study show that chia oil consumption during pregnancy and breastfeeding increases the content of ALA (76%) and EPA (57%) in erythrocyte phospholipids and the content of ALA (60%) and DHA (50%) in breast milk.5

Before Xia Oil supplementation (start of supplementation at 6th month of pregnancy)

After 3 months of 12 g Xia Oil supplementation daily (delivery)

After 9 months of 12 g Xia Oil supplementation daily (6 months nursing)

Fatty acid composition of erythrocyte phospholipids of mothers during pregnancy and nursing after 9 months of supplementation of 12 g of Chia Oil daily.

Pregnant and breastfeeding women are recommended to consume both DHA and ALA omega-3s for their baby's brain and eye development.2,3,4

NEUROLOGICAL BENEFITS A recent trial found that women who take 5 g of omega-3s daily at the end of pregnancy and at the onset of

breastfeeding have a greater chance of alleviating some of the symptoms related to postpartum depression.6,7

SCIENTIFIC EVIDENCE

BENEFITS FOR HEALTHY CELLULAR FUNCTION AND SYSTEMIC BALANCE As plant-based omega-3 fatty acids will be naturally and

In addition to its role in producing EPA and DHA, omega-3 ALA has independent and specific effects on health.

efficiently biosynthesized and accumulated as circulating supplies of EPA/DHA. Then, Chia oil's anti-inflammatory effect is related to its pro-resolutive action on the inflammatory response

A higher intake of ALA supports heart health and promotes healthy cardiovascular function.10

via SPMs, derivated from the conversion of ALA to longer-chain fatty acids, EPA and DHA. Indeed EPA/DHA are the precursors of specialized pro-resolving lipid mediators (SPMs), such as resolvin, protectin, and maresin families, which have been considered vital nutrient components for maintaining overall health. In

Evidence suggests that ALA intake reduces the risk of ventricular arrhythmia by more than 25%.11,12

addition, chia oil itselft has important levels of bioactive compounds: phenolic acids, tocopherols and tocotrienols. Growing evidence indicates that SPMs are beneficial

ALA supplementation has been shown to support

strategies in supporting and promoting a healthy,

healthy and normal cholesterol and lipid levels.14

balanced inflammation response.8,9

CARDIOVASCULAR HEALTH

Several investigations have shown the beneficial effects of ALA administered

Supports overall vitality and a healthy body:

alone or as a component of food in lowering blood pressure.10,12,15,16

•

Healthy blood sugar metabolism1

Epidemiological evidence has shown that higher

•

Heart health and healthy

dietary ALA is associated with a balanced,

cardiovascular function

normal inflammatory response, as measured by inflammatory biomarkers.15,16

•

Maintains normal blood pressure

•

Cognitive and neurological health

•

Healthy weight management support

Higher ALA intake has been shown to

•

Joint comfort and normal joint

support healthy arterial function and

function

vascular integrity.10,12,15

•

Healthy skin barrier function

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

A New Perspective on ALA Metabolism and Conversion to Long-Chain Omega-3 EFAs NEW SCIENCE: GLOSSARY OF NEW CONCEPTS Polyunsaturated Fatty Acid (PUFAs) Biosynthesis Pathway: The metabolic pathway responsible for converting ALA into EPA/DHA and LA into AA, involving desaturation and elongation steps. The Basics of PUFAs Metabolic Pathway ß-Oxidation

Omega-3

Omega-6

Storage

Alpha-linolenic Acid (ALA)

Linolenic Acid (LA)

Cell membranes

Desaturases Elongases Desaturases Elongases

EPA

AA Cyclooxygenases (COX) Lipoxygenases

DHA D-Resolvins Maresins

Desaturases Elongases

Cyclooxygenases (COX) Lipoxygenases Prostaglandins

E-Resolvins

Protectins PRO-RESOLUTIVE

Thromboxanes Leukotrienes PRO-INFLAMMATORY

In mammals, except for felines, ALA is efficiently absorbed at the intestinal level (over 96%), where after passing through the intestinal cells, it has three possible metabolic routes: (i) storage, mainly in adipose tissue, with greater storage in women than in men47, (ii) hepatic β-oxidation18 and (iii) conversion to EPA and DHA (mainly hepatic, and to a lesser extent, neuronal).19

SCIENTIFIC EVIDENCE

Compound-Specific Isotope Analysis (CSIA): A cutting-

Cycling ALA and EPA/DHA: supplementing strategy

edge technique that measures the natural abundance

discovered by Dr Bazinet that combines chronic

of stable isotopes in individual fatty acids. This allows

ALA supply with periodic acute DHA or EPA DHA

researchers to track the metabolic pathways of omega-3s

supplementation. This halves the need for DHA for the

with great precision, revealing their conversion rate and

same biosynthesized level.

utilization in the body.

Retro-conversion: The hypothetical conversion of DHA

The Gas-Chromatography Combustion Isotope Ratio

back to EPA, which was previously believed, has been

Mass Spectrometry (GC-cIRMS) is the specific CSIA

largely refuted by recent research.

method used to measure the isotopic composition of

β-oxidation (Beta Oxidation): A metabolic process in

fatty acids.

cells where fatty acids are broken down step-by-step to

Tracer: A substance used to track the movement or

generate energy. It is highlighted as a major metabolic

metabolism of a compound of interest within a biological

route for ALA in the brain, comparable to its conversion

system. In CSIA, stable isotopes act as tracers.

into EPA and DHA.

Turnover refers to the dynamic process by which

Metabolic Demand refers to the body's dynamic need

DHA is consumed, renewed, or replaced in the body.

for DHA to support essential functions, particularly in

It encompasses both the synthesis and metabolic

the brain. The body tightly regulates the synthesis and

consumption of DHA, ensuring the body has an adequate

delivery of DHA to match its metabolic demand, ensuring

supply for its needs.

that tissues receive an adequate supply even when dietary

Steady-state refers to a dynamic equilibrium in which

intake or conversion rates vary.

the levels of DHA in the body are maintained relatively

Kinetics: The study of reaction rates and the mechanisms

constant. This steady state is achieved by balancing the

that control them. In this case, it refers to the kinetics of

synthesis of DHA from precursors like ALA and EPA and its

ALA conversion to DHA.

consumption or turnover in tissues.

Homeostasis: Maintaining a stable internal environment

Flux: It refers to the dynamic flow of DHA within the

in the body, including regulating omega-3 fatty acid levels.

body. This encompasses its synthesis from precursors

This involves complex feedback mechanisms to ensure

like ALA and EPA, its distribution to various tissues, and

optimal function.

its utilization and turnover. DHA flux is actively regulated

LA/ALA Ratio (Linoleic Acid/Alpha-linolenic Acid Ratio):

to meet the body's metabolic demands and maintain a steady state of DHA levels.

The diet’s ratio of omega-6 to omega-3 fatty acids. These fatty acids compete for enzymes in the long-chain PUFA

Half-life: The time it takes for the concentration of a

biosynthesis pathway. Recent research suggests that the

substance, like DHA, to decrease by half in the body. This

ALA content itself is a stronger determining factor for the

is a measure of how quickly the substance is eliminated or

conversion into EPA and DHA, rather than an excess of LA

metabolized. For example, DHA’s half-life in the brain is

being historically considered detrimental to this pathway.

912 days aprox.

Lipid Mediator: Omega-3s are crucial in producing

Tissue-dependent: It means the conversion of ALA (alpha-

specialized pro-resolving mediators (SPMs); bioactive

linolenic acid) to other omega-3 fatty acids, such as EPA

molecules derived from fatty acids. They are important in

and DHA, differs among various tissues.

inflammatory response.

Synthesis-Secretion Rate: The rate at which the body

Resolution: The process of actively stopping inflammatory

produces and releases DHA, particularly when meeting

response and promoting tissue repair, often mediated by

tissue demands. The synthesis-secretion rate of DHA is

specialized pro-resolving mediators (SPMs).

closely linked to its consumption or turnover in tissues,

SPM (Specialized Pro-resolving Mediator): Bioactive lipid

ensuring that the body maintains a steady state of DHA despite variations in dietary intake or conversion.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

mediators derived from omega-3 fatty acids that actively promote the resolution of inflammatory response.

What Does The New Science Say? Our previous understanding of the EPA DHA biosynthesis pathway involved several principles, such as

•

Dr Richard Bazinet

When ALA or EPA are administered, the tissue or blood levels of DHA do not appear to increase.

• •

from the University

of Toronto (and former ISSFAL President) is a

When DHA is administered, retro conversion to EPA

well-known and pioneer researcher on brain

occurs, explaining the increase in EPA blood levels.

lipid metabolism. As such, he and his group

ALA is converted to EPA but not to DHA.

work to improve our understanding of the EPA/ DHA endogenous biosynthesis pathway and its regulation. Dr. Bazinet introduces the new concept of turnover

A Disruptive Method

and half-life, looking at Omega-3s in a new manner:

High-precision measurements on differences

how much does our body really consume of it daily,

in natural isotope ratios in fatty acids (CSIA,

and how long does a molecule of Omega-3 live in

compound-specific isotope analysis)17 reveal

our body before being consumed.

critical new evidence on Omega-3s metabolism in humans and requirements in adults

NEW SCIENCE: SHIFTING THE WAY TO LOOK AT OMEGA-3 OMEGA-3 INDEX: THE TRADITIONAL WAY

Static Measurement "A Picture" Total Omega-3s Total Fatty Acids

= Omega-3s Index %

It measures the amount of EPA-DHA in the red blood cell membrane expressed as the percent of total fatty acids present only at that time.

Omega-3s

OMEGA-3 CSIA: THE DISRUPTIVE WAY

Dynamic Measurement "A Tracking" It tracks the movements of each fatty acid in the body by measuring the C-13 isotope at different stages, creating a dynamic model that shows how much was converted, used in each tissue, stored, and its precursor. 1: Diet 2: Conversion 3: Use 4: Storage

ALA

DHA

EPA

SCIENTIFIC EVIDENCE

The novel strategies for assessing n-3 PUFA metabolism in

If the brain converts 0.2–0.3% of plasma-derived ALA

humans with CSIA show that the stagnation in DHA levels

to DHA, not counting the approximately 1% EPA or DPA

following ALA/EPA supplementation is not caused by a

Omega-3, then an intake of 1200 mg per day of ALA

low conversion rate but by a DHA tissue utilization that

in human could result in the brain itself producing

matches its synthesis-secretion (turnover or metabolic

2.4–3.6 mg of DHA per day. If the various intermediaries

consumption). This means that the body adjusts the

are considered, since the brain contains very little EPA, this

production according to its needs.17

could be as much as 5–8 mg of DHA produced by the

Synthesis-secretion rates are minimally affected despite significant variations in plasma DHA pool sizes. This

brain per day. This is important since the adult human brain uses only 4 mg of DHA daily approximately. 23,29,30

suggests a more significant role for the turnover of newly

This synthesis-secretion rate supplies the total DHA

synthesized DHA as the primary determinant of

requirement in the brain and could cover up to 50% of

plasma DHA levels.

the DHA needs in other tissues (further studies must

The most significant new concept that has emerged with

confirm this percentage). 20,24

the latest science is the measure of the turnover or the

The new methodology of gas-chromatography combustion

flux of DHA the body needs. DHA synthesis from ALA

isotope ratio mass spectrometry (GC-cIRMS) that Dr

matches DHA tissue consumption levels of DHA,

Richard Bazinet uses has challenged much dogma about

independently of the ALA dose.

apparently low DHA synthesis rates. 21,31 The conversion

The human body successfully manages a dynamically changing and continually optimized endogenous flow of omega-3s from plant sources. Science suggests a low

rates from ALA and EPA to DHA may be higher than previously and conventionally believed in animals and humans.

daily brain DHA requirement and the ability to retain DHA, as demonstrated by its long half-life. 26,27,28

But Why haven't We Seen this Before? BETA-OXIDATION

MEASUREMENT LIMITATIONS

One of the main reasons ALA conversion has been

Human studies are virtually limited to blood-derived

described as low is the high percentage of ALA directed

cells analysis, i.e., red blood cells, neutrophils, or

towards ß-oxidation. About 67% of ALA in the brain

plasma compartments, whose half-life is not greater than

is directed towards ß-oxidation. However, this high

100 days. Blood analysis does not reflect the potential

percentage used for ß-oxidation is not unique to ALA;

elongation seen in tissue compartments such as the

other dietary-derived PUFAs are also ß-oxidized.

brain. 34,35 It measures the amount of EPA+DHA in the red

For omega-6 fatty acids and DHA, the amounts used for

blood cell membrane expressed as the percent of total

ß-oxidation are around 50% and 65%, respectively.

fatty acids present only in that location at that time.

We now know, thanks to new science, that the remaining

New concepts of flux, half-life, turnover (see Glossary)

percentage available for conversion into LCPUFAs is

are important to correctly assess the omega-3

enough to cover the requirements.

PUFAs metabolism.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

TISSUE-SELECTIVE BIOSYNTHESIS

derived from n-3 PUFA precursors such as ALA and EPA

There are significant differences in the conversion capacity

appear to be the main determinant of steady-state

between different cells, 35,36,37 indicating the selectivity

DHA levels in plasma. 39,41

and preference of tissues to biosynthesize certain ALA

GENDER DIFFERENCES

derivatives. 24,25

Human studies on ALA metabolism show gender-

ALA-enriched diets have significantly increased ALA, EPA,

dependent differences. In healthy young men,

and DPAn-3 in plasma, liver, and heart, and DPAn-3 and

approximately 8% of dietary ALA is converted to EPA,

DHA in the brain. 34,38,40,42,42,43,44,45

and 0.5% to 4% is converted to DHA.46 In healthy young

TURNOVER LEVELS

women, approximately 21% of dietary ALA is converted to

If almost all the endogenous plasma DHA appears to

EPA, and 9% is converted to DHA.47

be replaced by the exogenous ALA/EPA-derived DHA,

The greater capacity to generate long-chain PUFA from

it suggests that DHA levels are rigorously supported by

ALA in young women compared to men is related to

the elongation/desaturation of metabolic precursors and

the effects of estrogen, 48,49 that may increase the activity

that the metabolic consumption (or turnover) of DHA

of the desaturation/elongation pathway.50

Revisiting some previously established principles: Important New Theories Based on animal

DHA inhibits

CSIA shows EPA

DHA/EPA

When DHA

and human

elongase, which

does convert in

comes from

is the only

data, DHA is not

is responsible for

DHA, although

ALA, and the

supplied source,

retroconverted

converting EPA

DHA levels do

body regulates

high-quality

to EPA.

into DHA, and

not increase

its conversion

ALA is needed

EPA blood level

since conversion

rates following

to rescue EPA

increases since

rates follow

its needs.

functional

its turnover is

DHA metabolic

decreased.

demand.

20,21,53

levels. 51,52

SCIENTIFIC EVIDENCE

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Regulatory Status of Chia Oil Health, structure-function, and functional health claims A dietary supplement having 1 gram of Xia Oil (over 600 mg of Alpha-Linolenic acid) can claim:

USA – FUNCTION STRUCTURE CLAIMS

EUROPE – HEALTH CLAIM

JAPAN – FUNCTIONAL HEALTH CLAIM

Regulatory:

Federal Register - January 6, 2000 (page 1000 to

EFSA opinion reference 2009;7(9):1252,

Consumer Affairs Agency, Government of Japan.

1050) Food and Drug Administration Final Rule

2011;9(6):2203; according to Commission

under Food Labelling – 21 CFR Part 101.93

Regulation (EU) 432/2012 of 16/05/2012.

Statements Made for Dietary Supplements

Authorised function health claims related to

Concerning the Effect of the Product on the

alpha-linolenic acid and maintenance of normal

Structure or Function of the Body.

blood cholesterol concentrations:

The following are examples of structure/function claims regarding ALA Omega-3 and heart health that have been reviewed and confirmed to comply with dietary supplement regulations for use on

reported that alpha-linolenic acid is effective to pressure is slightly higher than normal range”.

blood cholesterol levels." Conditions and possible restrictions of use: Conditions and possible restrictions of use:

The amount of functional ingredient per

ALA Omega-3 promotes cardiovascular health

The claim may be used only for food which is at

recommended daily intake is 2.6 grams. The

ALA Omega-3 supports heart health

least a source of ALA as referred to in the claim

Chia Oil must be manufactured by Functional

SOURCE OF OMEGA 3 FATTY ACIDS as listed in

Products Trading Arica S.A, Benexia ś institutional

the Annex to Regulation (EC) No 1924/2006.

company name.

Dietary supplement manufacturers, however, are required to notify the FDA of such labelling. USA- Nutrient Content Claim:

•

“Chia seed oil contains alpha-linolenic acid. It is

ALA Omega-3 improves heart health

Conditions and possible restrictions of use:

•

consumer products:

lower the blood pressure of those whose blood “ALA contributes to the maintenance of normal

dietary supplement labels marketed in the U.S.:

• • •

Health function(s) Claim to be labelled on the

“Good Source of Omega-3 ALA”: 160 mg ALA per serving “High in Omega-3 ALA”: 320 mg ALA per serving

Information shall be given to the consumer that the beneficial effect is obtained with a daily intake of 2 g of ALA. EU- Nutrient Content Claim:

• •

“Good Source of Omega-3”: 300 mg ALA per 100 g/kcal “High in Omega-3”: 600 mg ALA per 100 g/kcal

SCIENTIFIC EVIDENCE

Chia Oil

Xia Oil Applications Science-Based Application Concepts Benexia has developed application concepts, supported by scientific evidence, across the following key health areas: •

Bone Health

•

Menopause & Post-Menopause Support

•

Male Fertility

•

Sports Nutrition & Recovery

•

Cognition & Neurological Support For Elderly

•

& Other Application Concepts In Functional Lipids Blends

Download the Complete Scientific Application Dossier Scan to review clinical evidence, formulation concepts and validated references.

APPLICATIONS CONCEPTS

Application Concept in Dietary Supplements/Functional Foods BONE HEALTH FOR POSTMENOPAUSAL WOMEN

CALCIUM + VITAMIN D + CHIA OIL ALA POWDER

INGREDIENTS

Calcium and vitamin D are essential for healthy bones.

Benexia ALA Powder 40 (microencapsulated chia oil [70%],

Combining these key nutrients with the highest

acacia gum [30%]), Calcium carbonate, vitamin D, natural

plant-based source of alpha-linolenic acid (ALA) may

flavor and color.

support strong bones and reduce joint inflammation as women age.

COMPOSITION/NUTRITION FACTS

RECOMMENDED FOR Women 50 and older

1 in 4 postmenopausal women in both Europe and the U.S. have osteoporosis

Alpha-Linoleic Acid

1.4 g

Calcium

400 mg (33% RDA)

Vitamin D

5,000 IU

RECOMMENDED INTAKE One 15-g scoop per day

1 in 3 women will have an osteoporotic

SUGGESTED FORMAT

fracture in their lifetime

450g (15.9 oz) jar (30 dosages) NUTRIENT CONTENT CLAIMS*

Fragility-related fractures may increase by 25% by 2034

•

Excellent source of omega-3s | USA

•

High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS* Alpha-Linolenic Acid and Calcium | USA •

Minimizes bone loss

•

Supports joint health

•

Support normal inflammatory response

Alpha-Linolenic Acid | EU ALA contributes to the maintenance of normal blood cholesterol levels. Calcium | EU Calcium helps reduce bone mineral loss in postmenopausal women KEY ADVANTAGES •

Sustainable

•

Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

The Science IN SUMMARY: Pairing omega-3s with calcium and vitamin D can offer additional bone and joint protection for women ages 50 and older. The benefits from ALA omega-3s may be greater than other forms of omega-3 supplementation such as DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid). THE EVIDENCE: OMEGA-3S

BONE METABOLISM

May enhance calcium absorption

The continuous process of forming

Omega-3 fatty acids may alter the lipid composition of cell membranes, helping cells take in more calcium that can

new bone tissue and breaking down,

then be put towards building and maintaining bone tissue.

or resorbing, old or damaged bone

These alterations may also reduce rates of calcium loss.

tissue to help bones maintain their

Supports healthy bone tissue formation and a normal

structural integrity.

inflammatory response to exercise Rates of low-grade inflammation naturally increase with age. Omega-3s offer protection by turning down the production of pro-inflammatory cytokines that may stimulate the breakdown, or resorption, or bone tissue. ALA omega-3 may be particularly effective at these tasks. Compared to supplementing with DHA and EPA, ALA supplementation is tied to: •

Significantly higher levels of Bone-specific alkaline phosphatase (BALP), a bone enzyme involved in generating new bone tissue.

•

Lower levels of markers of bone resorption, such as C-terminal telopeptide of type 1 collagen (CTX) and N-terminal telopeptide (NTx).

May enhance physical function Greater physical activity supports stronger, healthier bones. Among postmenopausal women, dietary intake of ALA omega-3 has been shown to positively impact key parameters of physical function in just three days, including faster walking speed, greater grip strength, lower fat mass, better balance, and increased squatting ability.

THE EVIDENCE: ALA VS. DHA When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. However, we know that women's bodies are more efficient than men, with a conversion rate of 21% for EPA and 9% for DHA. More significantly, methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.

APPLICATIONS CONCEPTS

Application Concept in Dietary Supplements/Functional Foods FUNCTIONAL COLLAGEN PEPTIDES POWDER FOR POST-MENOPAUSAL WOMEN EASY-MIX CHIA OIL + COLLAGEN PEPTIDES POWDER

INGREDIENTS

Alpha-linolenic acid (ALA), highly hydrolyzed bovine

Hydrolyzed bovine collagen peptides,

collagen peptides, and calcium combine synergistically

Benexia® ALA Powder 40 [chia oil (70%), acacia gum (30%)],

to offer joint protection and bone and anti-inflammatory

calcium carbonate].

support in a highly bioavailable, easy-to-mix drink powder.

COMPOSITION/NUTRITION FACTS

RECOMMENDED FOR

•

1,400 mg ALA omega-3s

Women ages 50+

•

10 g hydrolyzed bovine collagen peptides

•

400 mg calcium (31% VRN)

1400 mg Omega-3 ALA to

In the U.S., 6,000 women enter menopause each day.1

Musculoskeletal pain increases with age and may be tied to the onset of menopause. 2

Boost Physical Function

Reduce Low-Grade Inflammation

RECOMMENDED INTAKE One scoop (15 grams) daily for at least 3 months SUGGESTED FORMAT 450g (15.9 oz. 0.99lb) jar (30 dosages) NUTRIENT CONTENT CLAIMS* Excellent Source of Omega-3 | USA High in Omega-3 Fatty Acids | EU HEALTH CLAIMS: Alpha-linolenic acid | USA ALA omega-3s promote cardiovascular health Alpha-linolenic acid | EU ALA contributes to the maintenance of normal blood cholesterol levels Calcium | EU Calcium helps reduce the loss of bone mineral in postmenopausal women

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

The Science IN SUMMARY: Declines in the hormone estrogen can lead to or worsen joint pain during and after menopause. Dietary ALA omega-3s may improve joint health and physical capacity in older women, making them an effective way to delay and/ or prevent declines in function. THE EVIDENCE: ALA AND ENHANCED

THE EVIDENCE: ALA VS. DHA

PHYSICAL FUNCTION

When it comes to getting our omega-3 needs met, ALA

•

Women with higher dietary ALA intake show

alone may be able to get the job done. Experts have

enhanced physical function parameters including

long believed that DHA and EPA are the "hero" sources

faster walking speed, greater grip strength, lower fat

of omega-3 fatty acids, since ALA was thought to have

mass, and better balance and squatting ability. 3

a poor rate of conversion to DHA. However, methods of

Supplementing with omega-3 fatty acids has

measuring rates of ALA conversion have advanced. Using

consistently been shown to relieve joint pain while

novel tracking strategies, scientists are now learning that

improving function.

DHA is stored in the body's tissues long-term, and only a

•

THE EVIDENCE: ALA REDUCES LOW-GRADE INFLAMMATION ALA supports joint health and balances exercise-induced inflammation response.5

small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.9,10,11

THE EVIDENCE: OMEGA-3S SUPPORTS MUSCLE HEALTH Omega-3s contributes to muscle protein synthesis. This can help prevent age-related muscle loss that can lead to frailness.6 THE EVIDENCE: OMEGA-3S AND HEART HEALTH Estrogen exerts a protective effect on the heart, where declining levels can increase a woman's risk for heart disease, heart attack, and stroke.7 Supplemental omega-3 can play a key role in combatting these problems by aiding in BMI and waist circumference reduction and lower blood pressure and triglycerides.8

REFERENCES Scan the QR code to access scientific references and claim validations. APPLICATIONS CONCEPTS

Application Concept in Dietary Supplements/Functional Foods OMEGA-3 BOOSTER FOR MENOPAUSE SUPPORT

CHIA + ALGAE OIL NUTRITIONAL DROPS

INGREDIENTS

Shifts in the hormone estrogen can cause unpleasant

Chia seed oil, algae oil.

symptoms during the menopausal transition. ALA and DHA omega-3 fatty acids can help manage these

COMPOSITION/NUTRITION FACTS

symptoms and support overall health. RECOMMENDED FOR Women ages 40 and older for perimenopausal and postmenopausal support.

Alpha-Linoleic Acid (ALA)

2,492 mg

Docosahexaenoic Acid (DHA)

258 mg

RECOMMENDED INTAKE One tsp (5 mL) up to twice per day. SUGGESTED FORMAT 130 mL (4.3 oz) bottle (26 dosages). NUTRIENT CONTENT CLAIMS* Excellent Source of Omega-3 | USA High in Omega-3 Fatty Acids | EU HEALTH CLAIMS* Alpha-Linolenic Acid | USA ALA may support the immune system

In the U.S., 6,000 women enter

Alpha-Linolenic Acid | EU

menopause each day

ALA contributes to the maintenance of normal blood

cholesterol levels KEY ADVANTAGES •

Sustainable

•

Plant-based source of omega-3s

Up to 80% of women experience menopause symptoms that adversely impact their quality of life and productivity2

Up to 80% of women are short on important nutrients such as omega-3 fatty acids3

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

The Science IN SUMMARY: Women become less effective at converting ALA omega-3s to DHA omega-3s during the menopausal transition. Supplementing with ALA and DHA omega-3s can support this reduced capacity, and in turn, help manage menopause-related symptoms. THE EVIDENCE: WOMEN AND OMEGA-3 CONVERSION

•

Night Sweats and Sleep Disruption. Hormone shifts

Research shows that younger women convert alpha-

can lead to night sweats that cause discomfort and

linolenic acid (ALA) to eicosapentaenoic acid (EPA) and

disrupt. However, omega-3 supplements may help

docosahexaenoic acid (DHA) much more efficiently

alleviate night sweats, which in turn can lead to more

than men, in large part thanks to estrogen. As estrogen

comfortable, less fragmented sleep.11

levels decline during menopause, the synthesis of ALA to DHA becomes downregulated, making omega-3 supplementation essential.4,5,6

THE EVIDENCE: ALA VS. DHA When it comes to getting our fill of omega-3s, ALA alone may be able to get the job done. Experts have long

THE EVIDENCE: OMEGA-3S IN MENOPAUSE

believed that DHA and EPA are the "hero" sources of

The menopausal transition is associated with an increased

omega-3 fatty acids, since ALA was thought to have a

risk for a range of symptoms and conditions. Many of

poor rate of conversion to DHA. However, methods of

those issues can be better managed with the help of

measuring rates of ALA conversion have advanced. Using

supplemental omega-3 fatty acids, including:

novel tracking strategies, scientists are now learning that

Heart Health. Estrogen exerts a protective effect on the

DHA is stored in the body's tissues long-term, and only a

heart, where declining levels can increase a woman's risk

small fraction of those reserves actually need to be topped

for heart disease, heart attack, and stroke.7 Supplemental

off each day. That replenishment hurdle can easily be

omega-3 can play a key role in combatting these problems

cleared with daily intake of ALA. While the conversion rate

by aiding in BMI and waist circumference reduction and

is small, it may actually be all that’s needed to maintain

lower blood pressure and triglycerides.

healthy DHA and EPA levels.

•

Mood and Brain Fog. The risk for mood disorders and cognitive impairment increases in menopause. Research suggests that supplementing with omega-3s can balances Mood, Focus, Mental Clarity, and Concentration.9

•

Promotes Joint Comfort. Thanks to hormone shifts and the natural effects of aging, more than half of women experience joint discomfort during and after menopause. Supplementing with omega-3 fatty acids has consistently been shown to relieve this discomfort while improving function.10

REFERENCES Scan the QR code to access scientific references and claim validations. APPLICATIONS CONCEPTS

Application Concept in Dietary Supplements/Functional Foods MALE FERTILITY AND REPRODUCTIVE HEALTH

CHIA OIL + UBIQUINOL (COQ10)

COMPOSITION/NUTRITION FACTS

The highest plant-based source of alpha-linoleic acid (ALA) joins forces with the most active form of coenzyme Q10 to support sperm quality, modulate male reproductive

1,200 mg Alpha-linoleic Acid

200 mg Ubiquinol (CoQ10)

Improves sperm quality, modulates hormone health, Balances inflammatory response

Exerts anti-inflammatory effect; improves sperm density, motility, and morpholog

hormones, and support vascular health. RECOMMENDED FOR Men

Global rates of male fertility have steadily decreased since 1990

RECOMMENDED INTAKE

15% of couples worldwide are affected by

Two capsules daily

infertility

SUGGESTED FORMAT Softgel capsules

Male factors contribute to about 50% of

NUTRIENT CONTENT CLAIMS*

infertility cases

•

Excellent Source of Omega-3 | USA

•

High in Omega-3 Fatty Acids | EU

HEALTH CLAIMS* Alpha-Linolenic Acid and Q10 | USA •

Supports male reproductive health

•

Supports vascular and heart health

Alpha-Linolenic Acid | EU ALA contributes to the maintenance of normal blood cholesterol levels. KEY ADVANTAGES •

Sustainable

•

Plant-based source of omega-3s

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

The Science IN SUMMARY: Omega-3 supplements can play a key role in supporting male reproductive health through a number of different avenues, emerging research suggests. Combining omega-3s with ubiquinol may offer additional anti-inflammatory benefits.

Sperm Motility: Ability of sperm to move efficiently Sperm Morphology: The shape and structure of sperm cells Sperm Density: Number of sperm in a given volume of semen Functional Competence: Ability of sperm to fertilize an egg

THE EVIDENCE: OMEGA-3S May improve sperm quality. Higher levels of omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are tied to higher sperm counts and greater sperm motility

THE EVIDENCE: UBIQUINOL (COENZYME Q10) Men with unexplained low sperm count may benefit from ubiquinol. Supplements can exert an antioxidant effect that has been shown to improve sperm density, sperm motility, and sperm morphology.

and morphology. Omega-3 supplements may also help

THE EVIDENCE: ALA VS. DHA

sperm maintain their structural integrity and functional

When it comes to getting our fill of omega-3s, ALA alone

competence by fighting against oxidative stress.

may be able to get the job done. Experts have long

May modulate hormone production. EPA and DHA supplementation may enhance the production of the male reproductive hormone testosterone. That may provide a healthier environment for sperm production and maturation.

believed that DHA and EPA are the "hero" sources of omega-3 fatty acids, since ALA was thought to have a poor rate of conversion to DHA. But methods of measuring rates of ALA conversion have advanced. Using novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small

Support normal inflammatory response.

fraction of those reserves actually need to be topped off

Omega-3's anti-inflammatory properties counteract

each day. That replenishment hurdle can easily be cleared

the effects of chronic inflammation in the testes and

with daily intake of ALA. While the conversion rate is small,

the seminal vesicles. This also supports healthy sperm

it may actually be all that’s needed to maintain healthy

production and function.

DHA and EPA levels in the body.

REFERENCES Scan the QR code to access scientific references and claim validations. APPLICATIONS CONCEPTS

Application Concept in Dietary Supplements/Functional Foods POST-WORKOUT ALA SMOOTHIE FOR SPORTS RECOVERY ANTI-INFLAMMATORY CHIA OIL SMOOTHIE Optimize sports recovery and shorten time between workouts with a convenient, ready-to-drink smoothie with alpha-linolenic (ALA) omega-3 fatty acids, high-quality

Athletes may be at higher risk for omega-3 insufficiencies.1

protein, and natural antioxidants. RECOMMENDED FOR

Omega-3 supplementation can improve

High-performance athletes

deficiencies and yield performance and

INGREDIENTS

recovery benefits.

Mixed berry juice from concentrate, whey protein, pectin, Benexia Chia Oil (63% ALA), natural raspberry flavor,

1600 mg Omega-3 ALA for

sunflower seed protein, rosemary extract, tocopherols. COMPOSITION/NUTRITION FACTS

Supplement Facts

High Athletic Performance

Serving Size: 1 (8.45 FL OZ) (250 mL) Amount per Serving

Daily Value*

Calories

252

Total Fat 8g

10%

Saturated Fat 1.5g

12%

NUTRIENT CONTENT CLAIMS Excellent Source of Omega-3 | USA

Trans Fat 0g

High in Omega-3 Fatty Acids | EU

Monounsaturated Fat 3.7g

Excellent Source of Protein | USA

Polyunsaturated Fat 2.5g

High Protein | EU

Omega-3 ALA 1600 mg Cholesterol 74mg

24.7%

HEALTH CLAIMS*

Sodium 180mg

7.8%

Alpha-Linolenic Acid | USA

Total Carbohydrates 25g Dietary Fiber 1.5g

9% 5.3%

Total Sugars 23g Includes 0g Added Sugars Protein 20g

Muscle Repair, Refuel & Recovery

0% 40%

* The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2000 calories a day is used for general nutrition advice.

RECOMMENDED INTAKE One serving (250 ml ) up to twice per day.

•

Strengthen heart health for cardiovascular support

•

Support immune system

Alpha-Linolenic Acid | EU ALA contributes to the maintenance of normal blood cholesterol levels. KEY ADVANTAGES • Sustainable • Plant-based source of omega-3s

SUGGESTED FORMAT 250 ml bottle (1 dosage).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

The Science IN SUMMARY: Omega-3s may help athletes perform at a higher level during physical activity and experience faster recovery times with less muscle discomfort.

THE EVIDENCE: ALAS AND MUSCLE PERFORMANCE

THE EVIDENCE: ALA VS. DHA

High consumption of ALA (1.9 g/day) is tied to better

When it comes to getting our fill of omega-3s, ALA alone

aerobic performance compared to low consumption of

may be able to get the job done. Experts have long

ALA (0.75 g/day). ALA has been shown to improve oxygen

believed that DHA and EPA are the "hero" sources of

use efficiency. It also promotes the use of fat for energy

omega-3 fatty acids, since ALA was thought to have a

during prolonged exercise after carbohydrate sources

poor rate of conversion to DHA. However, methods of

have been depleted.

measuring rates of ALA conversion have advanced. Using

THE EVIDENCE: OMEGA-3S AND RECOVERY Omega-3 supplementation may turn down the body's inflammatory response and decrease oxidative stress after exercise. This may reduce exercise-induced muscle damage, which in turn may support faster recovery times. 3 THE EVIDENCE: OMEGA-3S + WHEY PROTEIN

novel tracking strategies, scientists are now learning that DHA is stored in the body's tissues long-term, and only a small fraction of those reserves actually need to be topped off each day. That replenishment hurdle can easily be cleared with daily intake of ALA. While the conversion rate is small, it may actually be all that’s needed to maintain healthy DHA and EPA levels.5,6,7

High-quality protein sources like whey have long been known to support muscle recovery after physical activity. Consuming whey with omega-3 fatty acids before exercising may add to these benefits. The combination has been shown to improve strength and power and reduce delayed-onset muscle soreness.4

APPLICATIONS CONCEPTS

Application Concept in Dietary Supplements/Functional Foods INSTANT PORRIDGE ABSORPTION-OPTIMIZED NUTRIENT BLEND FOR ELDERLY EASY-MIX CHIA OIL POWDER Cognitive and neurologic support from alpha-linolenic acid (ALA) omega-3s for older adults, offered in a highly

The world's older population (ages 60+) will jump by 56% in the next 10 years.1

bioavailable, tasty stir-and-serve porridge.

The number of older adults with dementia worldwide is projected to double by 2030, reaching 78 million. 2

RECOMMENDED FOR Senior adults INGREDIENTS Benexia® ALA Powder 40 [Chia Oil (70%), Acacia Gum (30%)], quinoa flour, rice flour, modified corn starch, pea protein, calcium carbonate, vitamins and minerals, inulin, natural banana flavor, arabic gum,

Dietary supplements are widely recognized as a way to enhance cognitive ability and prevent or slow decline. 3

tocopherols, ascorbil palmitate, guar gum.

4800 mg Omega-3 ALA for

COMPOSITION/NUTRITION FACTS Per 4 tablespoons (50 g) powder (250 g reconstituted product):

Nutrition Facts

Cognitive support

Serving size (250 g reconstituted product) Amount per Serving

Calories

408 Daily Value*

Total Fat 13.3g

17%

Saturated Fat 3g

15%

Monounsaturated Fat 3g

SUGGESTED FORMAT 300g pack (6 servings). NUTRIENT CONTENT CLAIMS* Excellent Source of Omega-3 | USA

Polyunsaturated Fat 7.3g

High Omega-3 Fatty Acids | EU

Omega-3 ALA 4800 mg

With more than 600 mg of omega-3 ALA per serving

Cholesterol 0mg

Sodium 248mg

11%

Total Carbohydrates 55.5g

20%

HEALTH CLAIMS*

Dietary Fiber 2g

Alpha-linolenic acid | USA

Total Sugars 9.3g Protein 14g

Neurological protection

28%

* The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2000 calories a day is used for general nutrition advice.

RECOMMENDED INTAKE

•

ALA omega-3s promote cardiovascular health

•

ALA omega-3s may support immune health

Alpha-linolenic acid | EU ALA contributes to the maintenance of normal blood cholesterol levels.

Four tablespoons (50 g) prepared with 200ml of milk, water, or any nutritional formula up to twice daily. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

The Science IN SUMMARY: In summary: Adequate or supplementary ALA omega-3s for older adults against cognitive declines and neurologic conditions.

THE EVIDENCE: ALA OMEGA-3S AND

THE EVIDENCE: ALA VS. DHA

COGNITIVE DECLINE

When it comes to getting our fill of omega-3s, ALA alone

•

Dietary intake of omega-3 fatty acids during older

may be able to get the job done. Experts have long

adulthood may reduce the risk of all-cause dementia

believed that DHA and EPA are the "hero" sources of

or cognitive decline by 20%.

omega-3 fatty acids, since ALA was thought to have a

•

ALA supplementation during midlife, years before the

poor rate of conversion to DHA. However, methods of

onset of cognitive decline symptoms may help slowed

measuring rates of ALA conversion have advanced. Using

brain glucose metabolism, which contributes to the

novel tracking strategies, scientists are now learning that

development of neurodegenerative conditions.

DHA is stored in the body's tissues long-term, and only a

THE EVIDENCE: ALA OMEGA-3S AND NEUROLOGIC PROTECTION •

ALA supplementation supports brain health and increases antioxidant activity by increasing levels of brain-derived neurotrophic factors (BDNF), which

promotes the growth of new nerve cells in the brain.6 •

Low levels of BDNF may increase stroke risk and inhibit stroke recovery, while targeting BDNF levels may support stroke recovery7, suggesting that ALA may supports cognitive function, mental clarity, and neurological health.8

REFERENCES Scan the QR code to access scientific references and claim validations. APPLICATIONS CONCEPTS

Application Concepts in Dietary Supplements Benexia's virgin, cold-pressed Xia Oil is the highest 100% natural plant-based source of omega-3 with 63% ALA. With an exceptional range of bioactive compounds that potentiate and amplify omega-3 physiological effects, its series of polyphenols, tocopherols and plant sterols are characterized by having an adjuvant role in anti-inflammatory processes, which in combination with ALA, bring remarkable health benefits when consumed while providing an outstandingly high Oxygen Radical Absorbance Capacity (ORAC) and an excellent Oxidative Stability. Also, it has a light, clean flavor, making it the ideal omega-3 profile enrichment.

Potential Product Blends & Concepts FISH EPA/DHA + CHIA OIL ALA EPA + DHA + ALA: Enhanced Absorption of Essential Omega-3s

POSSIBLE CONCEPTS/POSITIONINGS FISH OIL PLUS SINGLE STRENGTH “PLUS” DOUBLE STRENGTH OMEGA-3 PLUS ALA + DHA STRENGTH CHIA PLUS

Virgin plant-based chia oil blend > 60% Essential ALA + high-quality fish oil

TRIPLE STRENGTH OMEGA-3 PLUS CARDIOVASCULAR BOOSTER

STRUCTURE/FUNCTION CLAIMS* | USA

A more sustainable omega-3 offer

ALA-DHA Scientific evidence demonstrates that diets that includes omega-3 fatty acids (DHA and ALA) may: • Strengthens heart health for cardiovascular support. • Supports immune system.

Boost competitiveness and long-term

• Improves brain development during pregnancy

stable prices

and lactation. • Promotes healthy skin, hair and nails.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

New Solutions for Real Opportunities FISH EPA/DHA + CHIA OIL ALA BLENDS & FORMULATIONS

POSITIONING

STRATEGY

ALA + EPA DHA 1812 • High Volume / Rotation High ALA Chia Oil (70-80%) + Low EPA DHA

• FISH OIL PLUS

• Competitive cost

1812 (30-20%)

• REFINED FISH OIL "PLUS"

• Supply predictability • Price stability

ALA + EPA DHA 3020 ALA Chia Oil + EPA DHA 3020 (50%-50%)

• FISH OIL PLUS • DOUBLE STRENGTH OMEGA-3 PLUS • ALA EPA DHA STRENGTH

• Optimized PUFAs composition • Nutritionally balanced

• ALA EPA DHA STRENGTH

• Volume

High ALA Chia Oil + EPA DHA 3020

• FISH OIL PLUS

• Supply predictability

(75%-25%)

• STRENGTH

• Price stability

• CHIA PLUS

• Enhanced PUFAs profile

ALA + EPA DHA 5020

High ALA Chia Oil + EPA DHA 5020 (65%-35%)

• Triple strength OMEGAs

• FISH OIL PLUS

• Supply predictability

• TRIPLE STRENGTH OMEGA-3 • PLUS CARDIOVASCULAR BOOSTER

KEY ADVANTAGES • Complete omega-3 fatty acid profile increasing nutritional and functional value

• Price stability • Highly concentrated

TARGET • Maternity • Brain and vision health

• Generate EPA & DHA biosynthesis by ALA + DHA supplementation

• Cardio - cholesterol

• Allergen-free ingredients

• Balanced nutrition

• No fishy flavor or reflux • Low saturated fats • Improved oxidative stability and organoleptic properties • 3 Health claims: ALA and Cholesterol, EPA DHA and Brain and Vision • MOSH / MOAH EU limit compliant • Environmentally conscious • Very cost-effective • More stable and predictable price and supply

APPLICATIONS CONCEPTS

Dietary Supplements: Chia Oil Soft Gel Caps Potential Product Blends & Concepts ALGAE DHA + CHIA OIL ALA ALA + DHA, fully plant-based Omega-3s: A full PUFAs offer20,25

POSSIBLE CONCEPTS/POSITIONINGS ALGAE CHIA PLUS

STRUCTURE/FUNCTION CLAIMS* | USA ALA-DHA Scientific evidence demonstrates that diets that includes

ALA + MARINE DHA

omega-3 fatty acids (DHA and ALA) may:

FULL VEGAN OMEGAs

• Strengthens heart health for cardiovascular support.

OPTIMIZED PUFAs FULL ANTIOX LIPIDS POTENCY EFAs METABOLISM BOOSTER

• Supports immune system. • Improves brain development during pregnancy and lactation. • Promotes healthy skin, hair and nails. HEALTH CLAIMS | EU Omega-3 ALA Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels. Recommended daily intake: 2g ALA. Omega-3 DHA Docosahexaenoic acid (DHA) maternal intake contributes

Virgin plant-based chia oil blend

to the normal brain development and normal development

> 60% Essential ALA + refined algal oil

of the eye of the foetus and breastfed infants. The beneficial effect for pregnant and breastfeeding women is obtained with a daily intake of 200mg of DHA in addition to the recommended daily intake for omega-3 fatty acids for adults (250mg DHA and EPA).

A fully sustainable omega-3 offer from plants

Competitive and predictable prices

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

New Solutions for Real Opportunities ALGAE DHA + CHIA OIL ALA BLENDS & FORMULATIONS

POSITIONING

STRATEGY

ALA + DHA 400

High ALA Chia Oil (70%)

• MARINE + PLANT-BASED OMEGAS PLUS

Low DHA (30%)

• ALA + MARINE DHA • EFAs METABOLISM BOOSTER

• Full plant-omega3 reserves • Enhanced DHA metabolism • Full supply predictability • Price stability • Sustainability

ALA + EPA/DHA 100 500 • ONLY FULL PLANT-BASED OMEGAS High ALA Chia Oil (65%)

• FULY OPTIMIZED

• Optimized PUFAs composition

Low EPA/DHA (35%)

• ALA/EPA/DHA Profile

• Nutritionally balanced

• EFAs METABOLISM BOOSTER ALA + EPA

High ALA Chia Oil (60 to 80%) Low EPA (20 to 40%)

• EFAs METABOLISM BOOSTER • ANTIOX LIPIDS FULL POTENCY • FULL VEGAN TRIPLE STRENGTH

KEY ADVANTAGES

• Optimized viscosity for capsule filling • Complete pack of bioactive compounds • Supply predictability • Price reduction

TARGET

• Generate EPA biosynthesis by ALA + DHA supplementation

• Maternity

• Allergen-free ingredients

• Brain and vision health

• No fishy flavor or reflux

• Cardio - cholesterol

• 100% Plant-based

• Balanced nutrition

• Low saturated fats • Improved oxidative stability • 3 Health claims: ALA and Cholesterol, EPA/DHA and Brain and Vision • MOSH / MOAH EU limit compliant • Environmentally conscious • Very cost-effective • More stable and predictable price and supply • Optimized viscosity for capsule filling

APPLICATIONS CONCEPTS

Dietary Supplements: Chia Oil Soft Gel Caps 100% CHIA OIL 100% Plant-based ALA: Omega-3 metabolism booster20,22

PRODUCT POSITIONING CHIA PLUS

KEY ADVANTAGES • 100% vegetal • 63% of plant-based omega-3

ENHANCE YOUR OMEGAs-3

• Omega-3 Metabolism Booster

FULL PLANT-BASED OMEGAS

• Generate EPA and DHA biosynthesis by ALA

BIOACTIVE CHIA POWER CHIA ACTIVE POWER ANTIOXIDANT CHIA POWER STRUCTURE/FUNCTION CLAIMS* | USA

supplementation • Allergen-free ingredients • No fishy flavor or reflux • 100% plant-based • Low saturated fats • Improved oxidative stability • Health claims: ALA and cholesterol

• Support heart and cardiovascular health.

• MOSH / MOAH EU limit compliant

• Support healthy inflammatory response.

• Environmentally conscious

• Supports immune system.

• Very cost-effective • Fully predictable price and supply

HEALTH CLAIMS | EU Omega-3 ALA Alpha-linolenic acid (ALA) contributes to the maintenance of normal blood cholesterol levels. Recommended daily intake: 2g ALA.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

• High in antioxidants, polyphenols, tocopherols and phytosterols. TARGET • Healthy Cardiovascular function • Balanced nutrition

Virgin plant-based chia oil > 60% Essential ALA

A fully sustainable omega-3 offer from plants

Competitive omega-3 alternative

APPLICATIONS CONCEPTS

Application Concept in Dietary Supplements ACTIVE INGREDIENTS SUPPLEMENTS NUTRITIONAL BOOSTER Benexia® Xia Oil is made from our cold-pressed premium chia seeds (Salvia hispanica) through a proprietary extraction process that carefully preserves chia oil's essential fatty acids and bioactive compounds. Chia oil is the richest source of Alpha-linolenic acid omega-3 (63% ALA) and contains important bioactive substances: tocopherols, polyphenols, and phytosterols. Benexia® Xia Oil also acts as a carrier for liposoluble compounds, boosting their intestinal absorption and enhancing each compound's functionality and efficacy. CONCEPTS CHIA OIL + ACTIVE LIPOSOLUBLE COMPOUNDS The highest plant-based source of alpha-linolenic acid with liposoluble vitamins (K2, retinol, D2/D3, E) and bioactive compounds for effective absorption, and antioxidant protection. KEY ADVANTAGES •

100% vegetal and sustainable sources of omega-3.

•

Lipid delivery system for better absorption

•

Non-GMO

•

Essential nutrients for healthy body

RECOMMENDED DAILY DOSE 2 capsules per day

1000 mg softgel oblong capsules

Enhanced functionality and efficacy of liposoluble compounds

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Formulation Concepts For Active Ingredients Supplements INGREDIENTS

ACTIVE COMPOUNDS

STRUCTURE/ FUNCTION CLAIMS* USA

HEALTH CLAIMS EU

TARGET

INMUNITY CHIA OIL + VITAMIN D3

Per 2 Capsules • Benexia® Chia Oil: 2000 mg • Vitamin D3: 50 mcg

Alpha-Linolenic (ALA) Acid • Improves heart and cardiovascular health. • Supports immune system. • Promotes healthy skin, hair and nails. Vitamin D • Essential for bone health. • Provides immune support. • Promotes healthy muscle function.

Alpha-Linolenic (ALA) Acid Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

• Immune system. • Cardio - cholesterol. • Balanced nutrition.

Vitamin D • Contributes maintenance of normal bones and teeth. • Normal muscle function. • A normal function of the immune system.

VISION CHIA OIL + VITAMIN A, ASTAXANTIN AND LUTEIN

Per 2 Capsules • Alpha-Linolenic (ALA): 1070 mg • Lutein: 20 mg • Astaxanthin: 4 mg

Alpha-Linolenic (ALA) Acid • Improves heart and cardiovascular health. • Supports immune system. • Promotes healthy skin, hair and nails.

Alpha-Linolenic (ALA) Acid Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

• Brain and vision health. • Antioxidant protection. • Senior.

Alpha-Linolenic (ALA) Acid Alpha-linolenic acid (ALA) contributes to maintenance of normal blood cholesterol levels.

• Antioxidant protection. • Hair, skin and nails. • Cardio - cholesterol.

Astaxantin • Provides antioxidant protection. • Naturally supports eye, joint and heart health. Lutein • Supports vision & eye health.

BEAUTY SKIN CHIA OIL + CO-ENZYME Q10

Per 4 Capsules • Alpha-Linolenic (ALA): 1700 mg • Q10: 100 mg

Alpha-Linolenic (ALA) Acid • Promotes healthy skin, hair and nails. • Supports the immune system. Co-enzyme Q10 • Powerful antioxidant and anti-aging. • Protects cells from damage. • Helps support heart function. • Increases energy production.

APPLICATIONS CONCEPTS

Chia Oil as a Food Dietary Supplement:

Simply add it to your food; it has a great taste!

Natural, plant-based

Essential for your health

Your daily Omega-3

63%

omega-3 ALA

Leet your food be your medicine Take a spoon per day

Light and delicate nutty taste

Ideal for enhancing meals, smoothies, beverages, or soups.

Sustainable food from regenerative agriculture

APPLICATIONS CONCEPTS

Nutritional Data Sheet PRODUCT Benexia® Xia Oil DATE June 2023 1: As this is a natural product, the values reported as typical may vary. 2: Calorie calculation (common conversion factors): In the US, use the 4-4-9 method, which assumes that each gram of protein contributes 4 calories to the caloric total, each gram of carbohydrates contributes 4 calories (less the amount of non-digestible carbohydrates), and each gram of fat contributes 9 calories (FDA). 3: In Canada and in the European Union, use the 4-4-9 adjusted for fiber. A value of 2 calories (8 kJ) per gram should be used for the dietary fiber portion of the fiber source.

Typical values1 per 100g 2

Energy (kcal/kJ)

900 / 3766

Energy (kcal/kJ)

900 / 3766

Total Fat (g)

100

Saturated fat

10.8

Polyunsaturated fat

81.9

(of which) Alpha- Linolenic acid

63.0

Linoleic acid

18.3

Monounsaturated fat

7.3

Trans fat

0.0

Cholesterol (mg)

0.0

Protein (g)

0.0

Total Carbohydrates (g)

0.0

Total Dietary Fiber

0.0

Soluble fiber

0.0

Insoluble fiber

0.0

Available Carbohydrates

0.0

Starch

0.0

Total Sugars

0.0

Poly-alcohols

0.0

Minerals /Vitamins (mg) Sodium

0.0

Phosphorus

0.0

Calcium

0.0

Potassium

0.0

Iron

0.0

Zinc

0.0

Magnesium

0.0

Vitamin D (mcg)

0.0

Antioxidants (umolTE/100g) Polyphenols (mg/100g) Caffeic acid

23.7

p-Coumaric acid

10.1

Total tocopherols (mg/Kg)

592

Alpha-tocopherols

26.0

Gamma-tocopherols

500

Delta-tocopherols

Oxygen Radical Absorbance

8,000

Total Sterols (g)

565

Ash (g)

0.0

Moisture (g)

0.0

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Technical Data Sheet PRODUCT Benexia® Xia OIl DATE May 2023 DESCRIPTION Benexia® Xia Oil is a golden-colored, transparent, and brilliant oil obtained through a proprietary premium technology, ensuring the most natural cold-press extraction of plant-based omega-3 from chia seed (Salvia hispanica L.).

Physical - Sensorial

Specification

Method*

Peroxide value**1

≤ 10 mEq O2/Kg

AOCS Cd 8-53

Free fatty acids1

≤ 2 % oelic acid

AOCS Ca 5a-40

Acidity value1

≤ 4 mg KOH/g

By calculation

Density

≤ 1 g/cm

AOCS Cc 10c-95

Insoluble impurities2

≤ 0.05 %

AOCS Ca 3a-46

Color1

Yellowish

Visual

Appearance1

Crystalline and brilliant liquid Visual

Taste and smell1

Slightly toasted nutty

Internal

Nutritional

INGREDIENTS 100 % chia oil

Alpha linolenic acid (ω3)2

≥ 60 %

GC-FID

FORMAT AND PACKAGING MATERIAL 190 Kg enamelled drum Packed under modified atmosphera (MA), replacing oxygen by nitrogen.

Linolenic acid (ω6)

≥ 15 %

GC-FID

Oleic acid (ω9)2

≥5%

GC-FID

Total plate count1

≤ 100 CFU/g

ISO 4833

Yeasts

≤ 10 CFU/g

ISO 21527

≤ 10 CFU/g

ISO 21527

≤ 10 CFU/g

AOAC 991.14

Enterobacteriaceae1

≤ 10 CFU/g

ISO 21528-2

St. aureus

≤ 10 CFU/g

ISO 6888-1

Absence

AOAC 991.14

Absence

Manual OXOID

Absence (0/25g)

ISO 6579

Arsenic2

≤ 0.1 ppm

AOAC 986.15

Cadmium2

≤ 0.1 ppm

AOAC 986.08

Lead

≤ 0.1 ppm

AOAC 999.11

Mercury2

≤ 0.1 ppm

AOAC 971.21

Copper

≤ 0.4 ppm

AOAC 999.11

Iron2

≤ 2.5 ppm

AOAC 999.11

≤ 5.0 g/Kg

GC-FID

≤ 10.0 ppb

GC-MS/MS

BEST BEFORE DATE AND STORAGE 24 months, stored in a cool dry place in original unopened package. Recommended storage conditions: Temperature <20 oC and <60 % of relative humidity. Once opened, it is recommended to consume the whole drum or refill with nitrogen before sealing. CERTIFICATIONS FSSC 22000 Halal and Kosher QUALITY ASSURANCE Additives: Free GMO: Free Allergens: According to allergen assessment. Contaminants: Comply with regulation. Suitable diets: Gluten free, vegetarian, vegan, keto, and low carb. APPLICATIONS Food, beverage, and nutraceutical ingredient. REGULATION Chia oil has been approved as Novel Food (Commission Decision 2014/890/EU). Custom Tariff Code: 15.15.9090 Origin: Chile.

Microbiological 1

Moulds1 Coliforms

E. coli2 Ps. aeruginosa

Salmonella spp.2 Contaminants

Erucic acid

Sum PAH's 42

* Or equivalent method ** At the end of the shelf-life period, if it has been stored according to instructions. The typical value at the date of manufacture is <2 meq O2/Kg. 1: Analysed per lot production 2: Analysed per yearly productions

NUTRITIONAL AND TECHNICAL INFORMATION

Technical Data Sheet PRODUCT Benexia® Xia Oil Organic DATE May 2023 DESCRIPTION Benexia® Xia Oil Organic is a golden-colored, transparent, and brilliant oil obtained through a proprietary premium technology, ensuring the most natural cold-press extraction of plant-based omega-3 from chia seed (Salvia hispanica L.).

Physical - Sensorial

Specification

Method*

Peroxide value**1

≤ 10 mEq O2/Kg

AOCS Cd 8-53

Free fatty acids1

≤ 2 % oelic acid

AOCS Ca 5a-40

Acidity value1

≤ 4 mg KOH/g

By calculation

Density

≤ 1 g/cm

AOCS Cc 10c-95

Insoluble impurities2

≤ 0.05 %

AOCS Ca 3a-46

Color1

Yellowish

Visual

Appearance1

Crystalline and brillant liquid

Visual

Slightly toasted nutty

Internal

Taste and smell

Nutritional

INGREDIENTS 100 % chia oil organic.

Alpha linolenic acid (ω3)2

≥ 60 %

GC-FID

FORMAT AND PACKAGING MATERIAL 190 Kg enamelled drum Packed under modified atmosphera (MA), replacing oxygen by nitrogen.

Linolenic acid (ω6)

≥ 15 %

GC-FID

Oleic acid (ω9)2

≥5%

GC-FID

Total plate count1

≤ 100 CFU/g

ISO 4833

Yeasts

≤ 10 CFU/g

ISO 21527

≤ 10 CFU/g

ISO 21527

≤ 10 CFU/g

AOAC 991.14

Enterobacteriaceae1

≤ 10 CFU/g

ISO 21528-2

St. aureus

≤ 10 CFU/g

ISO 6888-1

Absence

AOAC 991.14

Absence

Manual OXOID

Absence (0/25g)

ISO 6579

≤ 0.1 ppm

AOAC 986.15

≤ 0.1 ppm

AOAC 986.08

≤ 0.1 ppm

AOAC 999.11

≤ 0.1 ppm

AOAC 971.21

Copper

≤ 0.4 ppm

AOAC 999.11

Iron2

≤ 2.5 ppm

AOAC 999.11

≤ 5.0 g/Kg

GC-FID

≤ 10.0 ppb

GC-MS/MS

BEST BEFORE DATE AND STORAGE 24 months, stored in a cool dry place in original unopened package. Recommended storage conditions: Temperature <20 oC and <60 % of relative humidity. Once opened, it is recommended to consume the whole drum or refill with nitrogen before sealing. CERTIFICATIONS FSSC 22000 Halal and Kosher Organic under EU regulation. Organic quality NOP/USDA - COR equiv. QUALITY ASSURANCE Additives: Free GMO: Free Allergens: According to allergen assessment. Contaminants: Comply with regulation. Suitable diets: Gluten free, vegetarian, vegan, keto, and low carb. APPLICATIONS Food, beverage, and nutraceutical ingredient. REGULATION Chia oil has been approved as Novel Food (Commission Decision 2014/890/EU). Custom Tariff Code: 15.15.9090 Origin: Chile.

Microbiological 1

Moulds1 Coliforms

E. coli2 Ps. aeruginosa

Salmonella spp.2 Contaminants Arsenic2 Cadmium

Lead2 Mercury

Erucic acid

Sum PAH's 42

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Nutritional Data Sheet PRODUCT Benexia® ALA Powder DATE July 2023 1: As this is a natural product, the values reported as typical may vary. 2: Calorie calculation (common conversion factors): In the US, use the 4-4-9 method, which assumes that each gram of protein contributes 4 calories to the caloric total, each gram of carbohydrates contributes 4 calories (less the amount of non-digestible carbohydrates), and each gram of fat contributes 9 calories (FDA).

Typical values1 per 100g 2

Energy (kcal/kJ)

678 / 2834

Energy (kcal/kJ)

603 / 2525

Total Fat (g)

Saturated fat

Polyunsaturated fat

(of which) Alpha- Linolenic acid

Linoleic acid

Monounsaturated fat

Trans fat

Cholesterol (mg)

Protein (g)

0.1

Total Carbohydrates (g)

Total Dietary Fiber

Total Sugars

Other Carbohydrates

Minerals /Vitamins (mg) Sodium

0.1

Phosphorus

Calcium

Potassium

Iron

Zinc

Magnesium

Vitamin D (mcg)

Ash (g)

Moisture (g)

NUTRITIONAL AND TECHNICAL INFORMATION

Technical Data Sheet PRODUCT Benexia® ALA Powder 40

Physical - Sensorial

Specification

Method*

DATE October 2024

Appearance1

Powder

Visual

Solubility1

100 %

Visual

Color1

Creamy, light yellow

Visual

Total moisture1

≤4%

AOAC 934.01

Total fat

≥ 70 %

Soxhlet

Alpha linolenic acid2

≥ 40 %

Gas chromatography

Linolenic acid

≥ 10 %

Gas chromatography

24 %

Typical value

Total plate count1

≤ 10,000 CFU/g

Bam. chap. 3

Yeasts

≤ 100 CFU/g

ISO 21527

≤ 100 CFU/g

ISO 21527

St. aureus

Absence/g

ISO 6888-1

Coliforms1

≤ 10 CFU/g

ISO 4832

E. coli

Absence/g

ISO 7251

Salmonella2

Absence (0/25g)

ISO 6579

≤ 0.1 ppm

AOAC 986.15

DESCRIPTION Benexia® ALA Powder 40 is a microencapsulated spray-dried Benexia® Xia Oil and Acacia gum with 40% omega-3 content. This soluble powder has no taste and boasts a very good oxidative stability. INGREDIENTS Chia oil and acacia gum FORMAT AND PACKAGING MATERIAL 20 Kg with inner lines and oxygen barrier bag. BEST BEFORE DATE AND STORAGE 18 months, stored in a cool dry place in original unopened package. Recommended storage conditions: Temperature <20 oC and <60 % of relative humidity. Once opened keep refrigerated. QUALITY ASSURANCE Allergen: Free Gluten free, vegetarian, and vegan.

Chemical 1

(of which) 2

Total fiber2 Microbiological 1

Moulds1

Contaminants Arsenic2

APPLICATIONS Food, beverage, and nutraceutical.

Cadmium

≤ 1.0 ppm

AOAC 986.15

REGULATION Origin: Malaysia

Lead

≤ 0.08 ppm

AOAC 986.15

Mercury2

≤ 0.05 ppm

AOAC 971.21

* Or equivalent method 1: Analysed per lot production 2: Analysed per yearly productions

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

References 1. 2. 3. 4. 5.

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Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing.Nutrients, 7(8), 6405-6424. https://doi.org/10.3390/nu7085289. Su, K. P., Huang, S. Y., Chiu, T. H., Huang, K. C., Huang, C. L., Chang, H. C., & Pariante, C. M. (2008). Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry, 69(4), 644-651. https://doi. org/10.4088/jcp.v69n0418 . Hsu, M. C., Tung, C. Y., & Chen, H. E. (2018). Omega-3 polyunsaturated fatty acid supplementation in prevention and treatment of maternal depression: Putative mechanism and recommendation. Journal of affective disorders, 238, 47-61. https://doi.org/10.1016/j.jad.2018.05.018. Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation. Metherel, Adam H. et al. Journal of Lipid Research, Volume 65, Issue 6, 100548. Sobrino A, Walker ME, Colas RA, Dalli J (2020) Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators. PLoS ONE 15(12): e0242543. Naghshi S, et al. Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies BMJ 2021; 375:n2213. Guizy, M., David, M., Arias, C., Zhang, L., Cofán, M., Ruiz-Gutiérrez, V., Ros, E., Lillo, M. P., Martens, J. R., & Valenzuela, C. (2008). Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid. Journal of molecular and cellular cardiology, 44(2), 323-335. https:// doi.org/10.1016/j.yjmcc.2007.11.004. Aleix Sala-Vila, Jennifer Fleming, Penny Kris-Etherton, Emilio Ros, Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition, Advances in Nutrition, 2022;, nmac016, https://doi.org/10.1093/advances/nmac016. Rallidis, L. S., Paschos, G., Liakos, G. K., Velissaridou, A. H., Anastasiadis, G., & Zampelas, A. (2003). Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis, 167(2), 237-242. https://doi.org/10.1016/s00219150(02)00427-6. Zhao, G., Etherton, T. D., Martin, K. R., Gillies, P. J., West, S. G., & Kris-Etherton, P. M. (2007). Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. The American journal of clinical nutrition, 85(2), 385-391. https://doi.org/10.1093/ajcn/85.2.385. Abdelhamid AS, et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2020, Issue 3. Art. No.: CD003177. Vuksan, V., Whitham, D., Sievenpiper, J. L., Jenkins, A. L., Rogovik, A. L., Bazinet, R. P., Vidgen, E., & Hanna, A. (2007). Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trial. Diabetes care, 30(11), 2804-2810. https://doi.org/10.2337/dc07-1144. Lacombe R et al (2020) Turnover of brain DHA in mice is accurately determined by tracer-free natural abundance carbon isotope ratio analysis. J Lipid Res Jan;61(1):116-126. Saunders DR, Sillery JK. Absorption of triglyceride by human small intestine: dose-response relationships. Am J Clin Nutr 1988; 48:988-91. Burdge GC. Metabolism of -linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids 2006; 75:161-8. Lin, Y.-H., Hibbeln, J.R., Domenichiello, A.F., Ramsden, C.E., Salem, N.M., Chen, C.T., Jin, H., Courville, A.B., Majchrzak-Hong, S.F., Rapoport, S.I., Bazinet, R.P. and Miller, B.V., III (2018), Quantitation of Human Whole-Body Synthesis-Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α-Linolenic Acid at Steady State. Lipids, 53: 547-558. Metherel A, et al (2019) Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a randomized control trial. Am J Clin Nutr 110(4) 823-831. Kim HK, Choi H. Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane. Lipids 2001; 36:1331-6. Domenichiello A, et al (2015) Is docosahexaenoic acid synthesis from a-linolenic acid sufficient to supply the adult brain? Progress in Lipid Research 59; 54-66. Anthony F Domenichiello, Alex P Kitson, Adam H Metherel, Chuck T Chen, Kathryn E Hopperton, P Mark Stavro, Richard P Bazinet, Whole-Body Docosahexaenoic Acid Synthesis-Secretion Rates in Rats Are Constant across a Large Range of Dietary α-Linolenic Acid Intakes1, The Journal of Nutrition, Volume 147, Issue 1, 2017, Pages 37-44, ISSN 0022-3166. Anthony F. Domenichiello, Alex P. Kitson, Chuck T. Chen, Marc-Olivier Trépanier, P. Mark Stavro, Richard P. Bazinet, The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats, The Journal of Nutritional Biochemistry, Volume 30, 2016, Pages 167-176.

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Demar Jr JC, Ma K, Chang L, Bell JM, Rapoport SI. alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J Neurochem 2005;94:1063-76. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. Fetal baboons convert 18:3n3 to 22:6n3 in vivo. A stable isotope tracer study. J Lipid Res 2001;42:581-6. Su HM, Bernardo L, Mirmiran M, Ma XH, Corso TN, Nathanielsz PW, et al. Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. Pediatr Res 1999;45:87-93. Rapoport SI, Rao JS, Igarashi M. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostag Leukotr Essent Fatty Acids 2007;77:251-61. Umhau JC, Zhou W, Carson RE, Rapoport SI, Polozova A, Demar J, et al. Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J Lipid Res 2008. J Thomas Brenna. DHA retroconversion revisited: dietary DHA spares endogenous EPA. Am J Clin Nutr 2019;110:789-790. Poumes-Ballihaut C, Langelier B, Houlier F, Alessandri JM, Durand G, Latge C, et al. Comparative bioavailability of dietary alpha-linolenic and docosahexaenoic acids in the growing rat. Lipids 2001; 36:793-800. Demar Jr JC, Ma K, Chang L, Bell JM, Rapoport SI. alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J Neurochem 2005;94:1063-76. Barcelo-Coblijn G, Collison LW, Jolly CA, Murphy EJ. Dietary alpha-linolenic acid increases brain but not heart and liver docosahexaenoic acid levels. Lipids 2005;40:787-98. Innis SM, Dyer RA. Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid. J Lipid Res 2002; 43:1529-36. Portolesi R, Powell BC, Gibson RA. Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. J Lipid Res 2007; 48:1592-8. Bordoni A, Lopez-Jimenez JA, Spanò C, Biagi P, Horrobin DF, Hrelia S. Metabolism of linoleic and alphalinolenic acids in cultured cardiomyocytes: effect of different N-6 and N-3 fatty acid supplementation. Mol Cell Biochem 1996; 157:217-22. Igarashi M, Ma K, Chang L, Bell JM, Rapoport SI. Rat heart cannot synthesize docosahexaenoic acid from circulating alpha-linolenic acid because it lacks elongase-2. J Lipid Res 2008; 49: 1735-45. Adam H. Metherel, R.J. Scott Lacombe, Juan J. Aristizabal Henao, Delphine Morin-Rivron, Alex P. Kitson, Kathryn E. Hopperton, Daniel Chalil, Mojgan Masoodi, Ken D. Stark, Richard P. Bazinet, Two weeks of docosahexaenoic acid (DHA) supplementation increases synthesis-secretion kinetics of n-3 polyunsaturated fatty acids compared to 8 weeks of DHA supplementation, The Journal of Nutritional Biochemistry,Volume 60,2018, Pages 24-3 4, ISSN 0955-2863. Barcelo-Coblijn G, Kitajka K, Puskas LG, Hogyes E, Zvara A, Hackler Jr L, et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n6 to n3 fatty acid ratio. Biochim Biophys Acta 2003;1632:72-9. Kim HK, Choi H. Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane. Lipids 2001; 36:1331-6. Spady DK. Regulatory effects of individual n6 and n3 polyunsaturated fatty acids on LDL transport in the rat. J Lipid Res 1993;34:1337-46. Ayalew-Pervanchon A, Rousseau D, Moreau D, Assayag P, Weill P, Grynberg A. Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo. Am J Physiol Heart Circ Physiol 2007; 293:H2296-304. Abedin L, Lien EL, Vingrys AJ, Sinclair AJ. The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig. Lipids 1999;34:475-82. McLennan PL, Dallimore JA. Dietary canola oil modifies myocardial fatty acids and inhibits cardiac arrhythmias in rats. J Nutr 1995;125:1003-9. Burdge GC, Jones AE, Wootton SA. Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. Br J Nutr. 2002;88(4):355-364. (PubMed). Burdge GC, Wootton SA. Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002;88(4):411-420. (PubMed). Burdge G. α-Linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care. 2004;7(2):137-144. (PubMed). Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr. 2004;80(5):1167-1174. (PubMed) Burdge GC, Calder PC. Dietary α-linolenic acid and health-related outcomes: a metabolic perspective. Nutrition Research Reviews. 2006;19(1):26-52. doi:10.1079/NRR2005113. Metherel AH, Irfan M, Chouinard-Watkins R, Trépanier MO, Stark KD, Bazinet RP. DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long-Evans Rats. J Nutr. 2019 Apr 1;149(4):586-595. Metherel AH, Klievik BJ, Cisbani G, Smith ME, Cumberford G, Bazinet RP. Blood and tissue docosahexaenoic acid (DHA, 22:6n-3) turnover rates from Ahiflower® oil are not different than from DHA ethyl ester oil in a diet switch mouse model. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Jan;1869(1):159422. Metherel A, Bazinet R (2019) Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion. Prog Lipid Res Oct; 76:101008.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Benexia Ingredients BENEXIA® BLACK AND WHITE CHIA SEED

BENEXIA® XIA POWDERS: PROTEIN AND FIBER SOURCES

BCS R

Benexia® Black Chia Seed Raw.

Xia Powder 125 LM is a fine and dispersible chia protein

BCS O R

Benexia Black Chia Seed Organic Raw.

powder, concentrated up to 42%. Xia Powder 435 LM is a

BCS LM

Benexia® Black Chia Seed Low Moisture,

fine chia fiber powder, concentrated up to 56% and with

pasteurized, RTE.

more protein than chia seed. Both are manufactured from

BCS O LM Benexia® Black Chia Seed Organic Low

the partially defatted Benexia® Chia, obtained through

Moisture, pasteurized, RTE.

MicroTech® technology.

WCS R

Benexia® White Chia Seed Raw.

XIA POWDER 125 W LM

WCS O R

Benexia White Chia Seed Raw.

Xia Powder 125 White Low Moisture.

WCS LM

Benexia® White Chia Seed Low Moisture,

XIA POWDER 125 W O LM

pasteurized, RTE.

Xia Powder 125 White Organic Low Moisture.

WCS O LM Benexia® White Chia Seed Organic Low Moisture, pasteurized, RTE. BENEXIA® XIA OIL: FATS INGREDIENTS Benexia® Xia Oil is chia oil, obtained through a

XIA POWDER 435 W LM Xia Powder 435 White Low Moisture. XIA POWDER 435 W O LM Xia Powder 435 White Organic Low Moisture.

proprietary premium technology, for a natural cold-press

BENEXIA® PREMIXES

extraction of the chia seed (Salvia hispanica L.).

This line offers this amazing nutrition found in chia

It contains 63% of omega-3.

seed in high-fiber, high-protein bakery premixes. These

XIA OIL

premixes check all the boxes: texture, taste, simplicity

Benexia® Xia Oil offers great opportunities to develop

and fortification. All the premixes include our ingredient

products in foods and beverage. We offer formulations

Benexia® Xia Powder 435 W LM.

for a broad range of food applications in fats, oils blends,

KETO/LOW-CARB

flavored oils, vegetable spreads, bakery, dairy, juices, condiments, and specialty retail oils. XIA OIL O Benexia® Xia Oil Organic.

GLUTEN-FREE GLUTEN-FREE AND KETO/LOW-CARB HIGH FIBER

stands for white, ground from white chia seeds.

means Low Moisture. The ingredient is processed through Microtech® technology.

indicates products from controlled organic cultivation.

XIA OIL, A NEW SUSTAINABLE SOURCE OF OMEGA-3 ALA

Benexia®, a leader in the industry Launched in 2000, Benexia® is a world leader in the production, processing, and commercialization of chia and chia-based ingredients. Our company is vertically integrated from agricultural production to final ingredients and solutions, including plant cultivation, extraction, concentration processes, and ingredients development. We guarantee traceability from the fields and certified quality (GAP, GMP-HACCP, and FSSC 22000). Benexia products are certified Halal and Kosher.

Sustainability and Corporate Responsibility Benexia employs regenerative agriculture to achieve lower carbon and water footprints from planting to harvesting. These practices are incorporated by the brand's farming partners in Bolivia, Argentina, and Paraguay. Harvested chia seeds are processed without the use of gas or water. Seeds are cleaned and separated using physical processes such as airflow and density-based separation methods, yielding a final seed product that's 99.95% pure. Since its founding in 2005, Benexia is dedicated to supporting the welfare of its local communities. Benexia is aligned with the United Nations' Sustainability Development Goals and is on track to complete its B Corp certification by 2025. Half of Benexia's partner shareholders are chia farmers. This guarantees fair pricing and technical support within the company's supply chain as well as full traceability of ingredients.

Our team, the best customer service We're passionate about health, wellbeing, and providing exceptional service for our customers. We offer support in formulation, nutrition, scientific and regulatory matters, with the best experts to assist your needs. Contact us for samples, application sheets and more information at info@benexia.com

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Tel: + (56 2) 2437 5820 | info@benexia.com |