CHAIR’S LETTER
“Our approach to science is deeply rooted in collaboration and interdisciplinary thinking, recognizing that the most impactful discoveries often emerge at the intersections of diverse ideas and expertise.”
January1,2025
DearMPBPColleaguesandFriends,
AsImarkmyfirstyearasChairofthisremarkable department,Iwanttocelebrateourachievementsandthank ourfaculty,staff,andtraineesfortheirdedicationandhard work Together,we’vemadesignificantprogress:
Publishedgroundbreakingstudiesinmanyareas IncreasedNIHandtotalfundingby$2M.
Totalnumberofgraduatestudentsincreasedby25%.
Promotedseveralfacultymembers,andnamedone endowedProfessorship.
Recruitedthreenewfacultymembers.
FourfacultyreceivedUVA/SOMawards.
Establishedthemedicalschool’sfirstdepartmental PostdoctoralAssociationandspearheadedthisvideo.
EstablishedtheMinorGraduateAwardforbestpaper,and theTammPostdoctoralAwardforoutstandingpostdoctoral fellows
Organizedmanysocialevents(symposiums,fallwelcome, retreatsandholidayparties)tobringpeopletogether.
EstablishedanannualPromotion&Tenurereviewforall juniorandresearchfaculty.
Faceliftedaportionof4thfloorPinnHallAnnexand upgradedSnyderBuildinginfrastructurewithnewdesks, benches,amini-MOLMART,15-minuteshuttleservice,and anewvendingmachine.
Theseaccomplishmentsreflectourstrongcommunityand collaborativespirit.I’mexcitedforwhatyeartwoholds.Thank youforyourdedicationandcommitment,andthankyoufor beinganessentialpartofourmission!
Warmestregards,
LingQi,PhD ProfessorandChair
Anne Kenworthy, PhD
Elected a 2023 AAAS Fellow
Anne Kenworthy, PhD, Professor in the Department and Associate Director for the Center for Membrane and Cell Physiology, has been elected a 2023 American Association for the Advancement of Science (AAAS) fellow for her contributions in membrane nanodomains, such as lipid rafts and caveolae assembly and function in health and disease. The AAAS is the world’s largest general scientific society. AAAS fellows are distinguished scientists, engineers, and innovators from around the world recognized for notable achievements spanning their careers. Being named an AAAS fellow is one of the most distinguished honors within the scientific community
It is a great honor to be part of a broader community devoted to discovering new knowledge and improving the human condition.
ANNE KENWORTHY, PHD
Jochen Zimmer, PhD
Named the Charles Slaughter Professor in Physiology
The Department is proud to announce Dr. Jochen Zimmer, Professor and HHMI Investigator in the department, as the inaugural holder of the Charles Slaughter Professorship in Physiology, effective July 1, 2024, through June 30, 2029. This recognition honors his contributions to physiology and biophysics, as well as his leadership in the department. Since joining UVA in 2009, he has made a significant impact on both research and teaching Dr Zimmer’s lab focuses on how cells construct carbohydrate-based structures, employing advanced techniques like X-ray crystallography and cryo-EM, with implications for health and disease.
“I am deeply grateful to the Department and the School of Medicine for recognizing and supporting our research endeavors. This further fuels my commitment to advancing scientific discovery and mentoring the next generation of researchers.”
JOCHEN ZIMMER, PHD
AWARDS
QUOTES FROM EXTERNAL EXPERTS
“I find it difficult to overstate my admiration for (Dr. Owens) one of the most wonderful scholars I have had the fortune to meet during my professional career. ”
Dr. Gary Owens Receives UVA Distinguished Researcher Award
On December 22, 2023, our colleague
Dr. Gary Owens, Robert M. Berne Endowed Professor and Director of the Robert M. Berne Cardiovascular Research Center, received the prestigious UVA Distinguished Researcher Award, which honors faculty members for their excellence in research, impactful discoveries, and leadership in their field. This recognition is a testament to Gary's remarkable achievements, unwavering dedication to research, service, and mentoring, and an illustrious career spanning over four decades at UVA.
“Dr. Tamm has consistently gone above and beyond, offering support during challenging times and providing constructive criticism when needed. His mentorship has left a lasting impact on my own role as a group leader and mentor.”
Dr. Lukas Tamm Receives UVA Faculty Mentor Award
On January 8, 2025, our colleague Dr. Lukas Tamm, Harrison Distinguished Professor and Director of the Center for Membrane and Cell Physiology, was awarded the UVA Research Mentor Award. This recognition highlights Dr. Tamm’s outstanding dedication to fostering the growth and success of our faculty and trainees. Through his mentorship, Dr. Tamm has consistently demonstrated a deep commitment to cultivating the next generation of scientists, offering invaluable guidance and support to many of our trainees His impact extends beyond the laboratory, shaping the careers of those he mentors and inspiring a lasting passion for research and discovery in this department, university and across the world.
Drs. Jochen Zimmer and Ilya Levental Receive 2024 Dean’s Excellence Awards for Faculty Research and Teaching
The University of Virginia School of Medicine is proud to announce that Dr. Jochen Zimmer has received the Dean’s Excellence in Faculty Research Award, and Dr. Ilya Levental has been honored with the Dean’s Excellence in Teaching Award for 2024. These awards recognize their outstanding achievements and dedication to advancing research and education
Dr. Zimmer, Charles Slaughter Professor and HHMI Investigator in the Department, is a leader in molecular physiology and structural biology and well known for his groundbreaking research on carbohydrate-based materials and their roles in cellular processes, with broad implications for health and disease.
Dr Levental, Professor and Director of Biophysics graduate program in the Department, is celebrated for his innovative teaching, commitment to student success, and creation of an inclusive, engaging learning environment.
Congratulating Drs Zimmer and Levental on the welldeserved recognitions!
QUOTES FROM FORMER AND CURRENT GRADUATE
STUDENTS, LEVENTAL LAB
“His mentorship style, characterized by intellectual rigor, personalized guidance, and unwavering support, has left a lasting impact on my academic and research endeavors.”
“Ilya’s care and encouragement have been instrumental in my journey from a timid graduate student to a confident researcher capable of presenting work to diverse audiences.”
AWARDS
QUOTES FROM EXTERNAL EXPERTS
“Based on his past and current contributions as well as his plans for future research, Dr. Zimmer has and will be a truly impactful force in multiple fields of basic and applied sciences!”
Jochen Zimmer, PhD
Zimmer named HHMI Investigator
Jochen Zimmer, PhD, Professor in the department, has been named an Investigator by the Howard Hughes Medical Institute (HHMI), the nation’s largest private biomedical research organization. This prestigious recognition, awarded to just 33 scientists out of over 800 applicants, honors researchers poised to transform our understanding of biology, human health, and disease. Zimmer is UVA’s second HHMI Investigator and the first in over 20 years. HHMI’s unique “people, not projects” approach provides Zimmer with approximately $9 million over seven years, granting him the freedom to explore diverse research areas.
“Dr. Jomaa is an energetic, driven, and superbly trained biochemist and structural biologist with a vision for high risk, high reward projects. He is poised to build a world class research team that operates at a high level and will make strong contributions to many fields.”
Ahmad Jomaa, Ph.D.
Jomaa named 2023 Searle Scholar
Ahmad Jomaa, PhD, Assistant Professor in the department, has been named a 2023 Searle Scholar. In a highly competitive process, the Kinship Foundation selected Dr. Jomaa to join a group of 15 exceptional young faculty from top institutions across the U.S. who were chosen from 175 applicants nominated by their home institutions to conduct high risk, high reward research in biological, chemical and engineering sciences. Dr. Jomaa is the first Searle Scholar selected from the University of Virginia since the inception of the program in 1981. His project “When cancer cells go to sleep: Regulation of protein synthesis during dormancy” is supported by $300,000 over 3 years.
Kandice Levental, Ph.D. and Ilya Levental, Ph.D.
Receive the Biophysics Society 2024 Avanti Award in Lipids
Drs. Kandice Levental, Associate Professor, and Ilya Levental, Professor, have received the 2024 Avanti Award in Lipids by the Biophysical Society. Recognized for their groundbreaking research in lipid biophysics, the Leventals have advanced the field by bridging classical membrane biophysics with cell biology.
Brant Isakson, PhD
Receives 2024 Robert M. Berne
Distinguished Lectureship
Brant Isakson, PhD, Professor in the Department and member of the Robert M. Berne Cardiovascular Research Center, has been awarded the 2024 Robert M. Berne Distinguished Lectureship by the American Physiological Society. Dr. Isakson’s pioneering research has uncovered the critical role of hemoglobin alpha in myoendothelial gap junctions and its impact on nitric oxide signaling and blood pressure regulation. His work has advanced our understanding of pannexin-based purinergic signaling in vascular health and disease. This award, named in honor of former UVA Physiology Chair Dr. Robert M. Berne, recognizes emerging leaders in cardiovascular research whose work drives innovation in the field.
“Their (Leventals) innovative work has made membrane biophysics more biologically relevant, It’s an honor to celebrate their achievements."
PUBLICATIONS
Huan Bao, Ph.D.
Jeehae Shin, Cameron J Douglas, Shanwen
Zhang, Ciaran P
Seath, Huan Bao.
Targeting Recycling Endosomes to Potentiate mRNA Lipid Nanoparticles.
Nano Lett. 2024 May 1;24(17):5104-5109.
UVA Researchers Discover New Strategies to Enhance Delivery of mRNA Therapeutics for Gene Therapy
Researchers, led by Dr. Huan Bao, Associate Professor in the Department, have discovered new ways to improve how lipid nanoparticles (LNPs) deliver mRNA, which could make mRNA-based treatments more effective. Their study, published in Nano Letters and led by the fellow Dr Jeehae Shin, focused on overcoming a major challenge: ensuring mRNA reaches its target inside cells. They found that targeting specific parts of the cell, called recycling endosomes, significantly improves delivery. The team also identified two small molecules, NAV and ES5, that enhance this process. These discoveries could lead to better mRNA therapies for treating diseases and advancing genetic medicine. Supported by NIH DP2GM140920 and R21AG078699
Gemin O, Gluc M, Rosa H, Purdy M, Niemann M, Peskova Y, Mattei S, Jomaa A. Ribosomes hibernate on mitochondria during cellular stress.
Nat Commun. 2024. Oct: 15 (1): 8666
Ahmad Jomaa, Ph.D.
Surprising Beer Discovery Could Help Starve Cancer
Ahmad Jomaa, PhD, Assistant Professor in the Department, was featured in Newsweek and Virginia media for his research on how beer yeast could help starve cancer. Dr. Jomaa and collaborators at EMBL in Germany discovered a novel adaptation in yeast cells that allows them to enter dormancy during nutrient scarcity a survival tactic similar to cancer cells. This finding, published in Nature Communications (2024), could lead to new strategies to make cancer cells more vulnerable to starvation and easier to treat. Supported by Searle Scholar.
Mauricio Torres, PhD and Ling Qi, PhD
New Study Reveals Key Mechanism Behind Cerebellar Ataxia and Neurodegeneration
Researchers in the Qi Laboratory, led by Dr. Mauricio Torres, have uncovered a critical factor in Purkinje cell neurodegeneration. Purkinje cells are essential for motor coordination, and their dysfunction is closely linked to cerebellar ataxia, a disorder that impairs balance and movement. Published in JCI Insight, the study provides new insights into the role of the ERAD pathway in this condition, which has remained unclear despite known genetic risk factors The findings identify the SEL1L-HRD1 complex as essential for maintaining Purkinje cell health and motor function, offering potential new targets in the treatment of neurodegeneration. This research was supported by NINDS, NIA, and NIGMS.
Gloria Sheynkman, Ph.D.
A New Way to “Align” Proteins –Towards Capturing All Protein Changes in All Patients
Researchers led by Dr. Gloria Sheynkman, an Assistant Professor in MPBP, have developed Biosurfer a computational tool that systematically tracks how variations in a patient’s genome and transcriptome lead to disease-relevant protein forms. By analyzing both the human reference genome and long-read RNA sequencing data, Biosurfer identifies protein changes resulting from myriad mechanisms such as alternative splicing and ribosomal frameshifting. This work underscores the importance of thorough protein annotation, aligning with the National Library of Medicine’s mission to equip clinical researchers with reliable bioinformatic tools for research in precision medicine
Torres M, et al.
Purkinje cellspecific deficiency in SEL1L-HRD1 endoplasmic reticulumassociated degradation causes progressive cerebellar ataxia in mice.
JCI Insight. 2024. Nov: 9: e174725
Murali M, Saquing J, Lu S, Gao Z, Jordan B, Wakefield ZP, Fiszbein A, Cooper DR, Castaldi PJ, Korkin D, Sheynkman G. Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversity.
Genome Research. 2025
GRANTS
“The research in the Bao Lab “has the potential to facilitate therapeutic developments that transform the twilight years from a period of decline into a vibrant extension of life.”
Huan Bao, Ph.D.
New award from AFAR to study the molecular mechanism of
aging
Dr. Huan Bao, Associate Professor in the Department, has been awarded a 2025 New Investigator grant from the Hevolution Foundation and American Federation for Aging Research (AFAR) to investigate novel mechanisms underlying cell aging, with a focus on membrane damage caused by bacterial infection. They aim to redefine our understanding of why we age and open the door to entirely new therapeutic strategies to control age-related diseases like arthritis or Alzheimer’s.
Huiwang Ai, PhD
Developing Next-Gen Bioluminescence Imaging Tools
Dr. Huiwang Ai, Professor in the Department, has been awarded an R01 grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB). The grant will fund his work on developing ATP-independent luciferases, luciferins, and bioluminescent calcium indicators. These next-generation tools aim to improve imaging experiments in small animals, advancing basic and preclinical research. Dr. Ai’s lab specializes in protein engineering and molecular biosensors, with a strong track record in creating imaging tools. His team is now exploring new applications, including diagnostics for self-wellness alerts, resourcelimited settings, and innovative cancer therapeutics.
PHYSIOLOGY & BIOLOGICAL PHYSICS NEWS MAGAZINE ~ 2025
Ling Qi, PhD
A New Award from NIH to Investigate Alzheimer’s Disease Pathogenesis
Dr Ling Qi, in collaboration with Dr. Zhen Zhao at University of Southern California, has been awarded a R01 grant from National Institute of Aging (NIA) to investigate novel mechanisms underlying Alzheimer’s disease, with a focus on the interplay between STING-mediated innate immunity and neuroinflammation. This research has the potential to deepen our understanding of this devastating disease and identify new therapeutic targets.
Brant Isakson, PhD
A New Award from NIH to Study the Role of Renin in Hypertension
Hypertension, a leading indicator o disease, is regulated by the renin-angiotensinaldosterone system (RAAS). Dysregulation of RAAS can cause hypertension, making it a key target for therapies like ACE inhibitors. Dr. Brant Isakson’s research, supported by a R01 grant from the National Institute of Heart, Lung and Blood (NHLBI), focuses on renin release the critical step in RAAS activation from juxtaglomerular cells in the afferent arterioles. His study examines the role of Pannexin1 channels in these cells and their potential interaction with PIEZO1 channels, aiming to uncover new pathways for hypertension treatment.
GRANTS
“This collaborative effort promises to advance our understanding of Alzheimer’s disease and identify potential therapeutic targets for this devastating condition.”
GRANTS
“I am grateful to the Owens Family Foundation for supporting this exciting project to examine mechanisms underlying male infertility at a pivotal stage in my career. ”
SEHAM EBRAHIM, PHD ASSISTANT PROFESSOR
Swapnil Sonkusare, PhD
Study the Vascular Mechanisms that Elevate Blood Pressure in Obesity
Dr. Swapnil Sonkusare, Associate Professor in the Department, has been awarded a R01 grant from the National Heart, Lung, and Blood Institute (NHLBI) to study the vascular mechanisms driving hypertension in obesity. Obesity is a major risk factor for hypertension and other cardiovascular diseases, leading causes of preventable death. Dr. Sonkusare’s research focuses on small arteries that regulate blood pressure. His work has shown that obesity impairs TRPV4 ion channels in endothelial cells, contributing to elevated blood pressure. This study aims to uncover the mechanisms behind TRPV4 dysfunction and disrupted calcium signaling, with the goal to identify new therapeutic targets to address hypertension in obesity.
“The generous support from the Owens Foundation will empower us to uncover the mechanics of mitochondrial import and how its dysregulation impacts human health.”
AHMAD JOMAA, PHD ASSISTANT PROFESSOR
Seham Ebrahim, PhD Ahmad Jomaa, PhD
Awarded Owens Family Foundation Grants
The Owens Family Foundation has awarded $300,000 over three years to Drs. Seham Ebrahim and Ahmad Jomaa to support exciting new research in their labs. The Ebrahim lab is studying the transmembrane channel-like (TMC) protein family, focusing on TMC5, which is essential for spermatid elongation and male fertility, with the goal of developing a non-hormonal male contraceptive. The Jomaa lab is investigating the role of the Nascent polypeptide-Associated Complex (NAC) in mitochondrial protein import, particularly in Parkinson’s disease, exploring how NAC deregulation may lead to protein mistargeting, aggregation, and neurodegeneration.
MOLECULAR PHYSIOLOGY & BIOLOGICAL PHYSICS NEWS MAGAZINE ~ 2025
LEADING EDGE
Innovation in Protein Sequencing
by Madison Mehlferber, PhD
At the Sheynkman Lab, we focus on the studying disease relevant proteins and their protein isoforms or “proteoforms” generated through the process of alternative splicing. To advance this research we have integrated state-of-the-art analytical and computational methods, drawing on data collected from genomics and proteomics to support a systems biology approach allowing for the connection between the transcriptome and proteome to elucidate the landscape of isoforms expression.
As we continue to explore this complex landscape, we are excited for the addition of a new cutting-edge technology platform within our lab: single-molecule protein sequencing as offered by Quantum-Si on their Platinum platform. This represents the first single-molecule protein sequencing application in the Commonwealth of Virginia. This innovative and fast-moving project has been led by our own, Natchanon (Bond) Sittipongpittaya The results of these collaborative efforts have already yielded significant results, including his first recent preprint titled “Protein sequencing with single amino acid resolution discerns peptides that discriminate tropomyosin proteoforms” which has created much excitement within the community about the promise of emerging “omics” technology and providing a mechanism by which to support isoform-driven discoveries. We are thrilled to be among the first to adopt this new technology and await eagerly the new discoveries that will come on our work to uncover the full breadth of protein isoform diversity.
Dr. Gloria Sheynkman, Doug Whitney, Katherine Johnson, Dr. Kenneth Skinner, Natchanon (Bond) Sittipongpittaya
From left to right:
LEADING EDGE
Muge Kuyumcu-Martinez, PhD
Unveiling Pioneering Research on Hypoplastic Left Heart Syndrome
Dr. Muge Kuyumcu-Martinez, Professor in the Department, leads cutting-edge research on Hypoplastic Left Heart Syndrome (HLHS). Her recent presentation and interview at the 2024 American Heart Association Basic Cardiovascular Sciences Conference, which received widespread acclaim, explored how mutations in the RNA binding protein RBFOX2 contribute to this serious congenital heart defect. Her research uncovers new mechanisms behind HLHS and opens potential pathways for RNA-based therapies. Supporting her work could significantly advance our understanding of HLHS and improve future treatment options for affected individuals A link to the video: https://www.youtube.com/watch?v=s7NCj-idM-g&t=12s
Huiwang Ai, PhD
Engages Audiences Worldwide in Celebration of National Chemistry Week and Mole Day
Huiwang Ai, PhD, Professor in the Department and the Center for Membrane and Cell Physiology, was honored as an expert during the American Chemical Society’s (ACS) National Chemistry Week and Mole Day celebrations. As part of ACS’s Program-in-a-Box event, themed Picture-Perfect Chemistry, Dr. Ai presented his research on molecular biosensors and their transformative role in biomedical science. His work was featured in an engaging 8-minute video, produced by ACS with support from UVA Health Marketing and Communications. The event reached a global audience, with over 340 participating groups and an estimated 9,000 attendees from countries such as the U.S., Nigeria, Ecuador, and Japan. Designed to inspire the next generation of scientists, the event engaged undergraduate and high school students worldwide in celebrating the impact of chemistry. A link to the video: https://med.virginia.edu/ai-lab/wp-content/uploads/ sites/365/2024/10/ACS-Video-low-quality.mp4
Link to video
Link to video
Brant Isakson, PhD
A Book on Dinosaur Physiology
Dr. Brant Isakson, professor in the Deparment and member of UVA's Cardiovascular Research Center, rele Sauropod: The Physiology of a Dinosaur on November 29 2024. The book explores how sauropods, the largest animals in history, may have functioned, drawing on Dr. Isakson’s expertise in physiology and metabolism. Inspired by his lifelong fascination with dinosaurs, he hypothesizes adaptations like air sacs in their necks to reduce weight and improve respiration. Written for both lay readers and experts, the book offers a creative exploration of sauropod biology, aiming to spark curiosity and inspire discovery.
The book link on Amazon
“The wondering and thinking and exploring is what makes kids fall in love with dinosaurs in the first place, and if I can bring that sort of joy to a reader, whether lay or scientist, I think that would be awesome. ”
BRANT ISAKSON, PH.D. PROFESSOR
WHO KNEW?
Avril Somlyo, PhD
Extreme Physiology
Claude Bernard, August Krogh, and Hans Krebs formulated the well-known principle “For many problems there is an animal on which it can be most conveniently studied” Krogh’s work on capillaries in frogs and Bernard’s discovery of vasomotor control in rabbits exemplify this approach. More recently, Nigel Unwin used ribosome arrays from hibernating lizards to solve the structure of the ribosome, while studies on humans in extreme environments offer insights into disease mechanisms beyond traditional models. Research on Burmese pythons revealed reversible massive organ growth after feeding, providing insights into cardiac hypertrophy and diabetes. Interestingly, fatty acids from post-prandial pythons induce cardiac hypertrophy in mice and cultured myocytes. Similarly, the exquisite adaptations that enable giraffes to thrive with the highest blood pressures of any animal on earth, offer lessons in managing cerebral perfusion and renal function. The naked mole-rat’s ability to survive low O2 and high CO2, along with its pain tolerance, provides potential breakthroughs for heart attacks, stroke, and pain management. Spiny mice, which regenerate organs without scarring, offer a model for understanding and preventing fibrosis in humans. These examples demonstrate how non-traditional models unlock physiological insights and advance human medicine.
Avril Somlyo, PhD, Emeritus Professor
Wladek Minor, PhD
30+ Years of Innovation at UVA
I joined the Department in December 1995, nearly 30 years ago. My research has centered on protein structure and other biomolecules an essential foundation for understanding their roles in biological systems. This work has been instrumental in identifying potential drug targets and advancing bioinformatics. I have been a member of five large NIH centers and have contributed to the development of widely used software, including HKL-2000/3000, CheckMyMetal, and CheckMyBlob. My 300 publications have collectively received over 64,000 citations. None of this would have been possible without the outstanding collaborators, both at UVA including John Herr, Zygmunt Derewenda, and Tom Platts-Mills and globally, with esteemed colleagues such as Zbyszek Otwinowski, Alex Wlodawer, Steven Almo, and Aled Edwards. A full list of collaborators can be found on my lab’s website. I have also been fortunate to mentor and work alongside many brilliant students, postdocs, and research professors, whose dedication continues to enhance UVA’s scientific contributions worldwide. More about their achievements can be found here Reflecting on this journey, I am deeply grateful for the remarkable people who have been part of it. It has been a privilege to contribute to UVA’s research community.
WHO KNEW?
Zygmunt Derewenda, Ph.D.
Experiences the Himalayas
In 2021, I trekked to Mount Everest Base Camp and Gokyo Lakes, followed by Annapurna Base Camp in 2022. Last November (2024), my son Jacob and I explored Upper Mustang, including the ancient city of Lo Mantang. Highlights? The breathtaking Himalayas, the stark impact of climate change on glaciers, and a pilgrimage tracing Guru Rinpoche’s 8th-century route. We visited meditation caves, stayed in his monastery, and reached Lo Mantang, a cultural treasure open to the West only since 1992 Enjoy the photos!
View of Mt. Everest (8,838 m) and Lhotse (8,516 m) from Gokyo Ri (5,357 m), overlooking Nepal’s largest glacier, Ngozumpa.
guide Kalden
On the way to Mount Everest One of the most beautiful mountains in the world, Ama Dablam (mother’s necklace) 6,812 m, climbed in 1961
Taking a break en route from Annapurna Base Camp, with Dhaulagiri (8,167 m), first climbed in 1960, in view
The beautiful and sacred Machupuchare, or Fishtail Mt 6,993 m, never climbed.
With
Sherpa on Kala Patthar (5,643 m) at 7:00 am, Mt Everest behind us
Overlooking the Kali Gandaki Gorge the world's deepest carved through the Himalayas between Annapurna (8,091 m, left) and Dhaulagiri (right) We flew through its 7 km deep passage in a tiny plane "
PROMOTIONS
Dr. Huiwang Ai promoted to Full Professor in 2023.
Dr. Ilya Levental promoted to Full Professor in 2024.
Dr. Stefanie Redmann promoted to Associate Professor in 2024.
Dr. Michael Purdy promoted to Research Associate Professor in 2024.
Dr. Rebecca Deaton promoted to Research Assistant Professor in 2025.
"I am honored and excited to join the department. This promotion presents an incredible opportunity to deepen my collaboration with colleagues in the Cardiovascular Center while forging new partnerships within MPBP. I look forward to engaging with fellow department members to explore new perspectives and approaches that will enhance our research and drive meaningful advancements."
Dr. Sohel Shamsuzzaman promoted to Research Assistant Professor in 2025
REBECCA DEATON, PHD RESEARCH ASSISTANT PROFESSOR
TRAINEE FELLOWSHIPS
“Mentoring trainees is essential for fostering the next generation of scientists, shaping not only their technical expertise but also their critical thinking, resilience, and creativity. By investing in their growth, we ensure the advancement of knowledge and the continued innovation needed to address future challenges.”
Dr. Yen-Lin Chen, Sonksuare lab, awarded NIH Pathway to Independence K99/R00 Award from NIDDK in 2024.
Dr. Luke Dunaway, Isakson Lab, was awarded a one-year postdoctoral fellowship (F32) from NHLBI in 2024.
Dr. Xinxin Chen, Qi lab, was awarded a three-year postdoctoral Fellowship from American Diabetes Association in 2023.
Dr. Xiaoqiong Wei, Qi lab, was awarded a two-year Postdoctoral Fellowship from American Society of Nephrology and was named 2023 Ben J. Lipps Research Fellow.
Dr. Yitao Huang, Guo lab, awarded 2year AHA Postdoctoral Fellowship in 2023.
Dr. Zefan Li, Ai lab, awarded UVA Cancer Center’s Trainee Fellowship. 2024
TRAINEE FELLOWSHIPS
Skylar Loeb (Molecular Physiology, Isakson Lab) was awarded a two-year NIH/NHLBI F31 Predoctoral Fellowship in 2025.
Zuzanna Juskiewicz (Molecular Physiology, Isakson Lab) was awarded a two-year Predoctoral Fellowship from American Heart Association (AHA), 2025.
Wyatt Schug (Molecular Physiology, Isakson Lab) was awarded a two-year Predoctoral Fellowship from AHA in 2025.
Victoria Milosek (Molecular Physiology, Owens Lab) was awarded a two-year Predoctoral Fellowship from AHA in 2025.
Linyao (Elina) Zhou (Molecular Physiology, Qi-Sun Lab) was awarded a two-year Predoctoral Fellowship from AHA in 2025.
Maciej Gluc (Biophysics, Jomaa lab) was awarded a three-year fellowship from the Boehringer Ingelheim Fonds in 2024.
Kevin Nguyen (Biophysics, Columbus Lab), received a Cell and Molecular Biology training grant (NIH T32) in 2024.
“I’m truly honored to receive this PhD Fellowship award. This achievement reflects not just my individual efforts, but also the exceptional resources provided by our department, particularly the cryo-EM facility, and the invaluable guidance of my PI, Dr. Jomaa.”
MACIEJ GLUC, BIOPHYSICS, GRADUATE STUDENT
JOMAA LAB
MOLECULAR PHYSIOLOGY & BIOLOGICAL PHYSICS NEWS MAGAZINE ~ 2025
TRAINEE FELLOWSHIPS
"I
am incredibly grateful to receive this recognition and deeply thankful for the encouragement of the MPBP department and my mentor, Dr. Sheynkman, whose guidance and mentorship have made this opportunity possible."
JENNIFER KORCHAK, BIOPHYSICS, GRADUATE STUDENT SHEYNKMAN LAB
Hannah Cannon, Levental and Kenworthy lab, was awarded a Cell and Molecular Biology training grant (NIH T32).
Rachel DeLancey, Kuyumcu-Martinez Lab, was awarded UVA Cardiovascular Research training grant (NIH T32).
Jennifer Korchak, Sheynkman Lab 2023 Semifinalist-Trainee Awards for Excellence in Human Genetics Research, ASHG
2023-2024 Cardiovascular Research Training Grant 2024 Seer Insights Grant, Seer Inc. 2024-2025 Wagner Fellowship, UVa
Sara Zdancewicz, Jomaa Lab, received the Michael J. Peach Outstanding Graduate Student Award.
Emir Maldosevic, Jomaa Lab, was awarded the Molecular and Cell Biology Training Program T32 fellowship.
Micah Lehe, Sheynkman Lab, was Awarded the Biotech T32 Training Grant.
TRAINEE AWARDS
2024 TAMM POSTDOCTORAL AWARD
Dr. Luke Dunaway, Isakson lab
Dr. Liangguang (Leo) Lin, Qi lab
2024 MINOR GRADUATE AWARD FOR BEST PAPER
“The trainees in our department are a well-spring of energy, enthusiasm, and scientific ingenuity. Their productivity on the bench drives the research in the department, but they are also critical mentors, teachers, and communicator of the impact of our work to the broader biomedical community. We are so proud and appreciative of their efforts, and our support of them will continue far beyond their stay in MPBP!”
ILYA LEVENTAL, PH.D. PROFESSOR DIRECTOR OF GRADUATE STUDIES, BIOPHYSICS PROGRAM
Jason Li, Qi lab
Jeremi Kuklewicz, Zimmer lab
Addie Walsh, Lukens lab
Skylar Loeb, Isakson lab
Hannah Cannon, Levental and Kenworthy lab
Sara Zdancewicz, Jomaa lab
NEW FACES
Jarred Whitlock, Ph.D. Assistant Professor
PhD: Emory University Postdoc: National Institute of Child Health and Human Development J A R R E D W H I T L O C K P H . D .
“That passion led me to study bird habits from the Carolinas to the Amazon and later to explore the intricate dance of cells different scales, same cosmic rhythm.”
Where are you from and how did you become interested in becoming a researcher?
I grew up in rural South Carolina but don’t really consider it “home” anymore. To me, we’re “from” wherever we stumbled into adulthood and paid our first bills. For me, that’s Atlanta a city of craft beer, hip-hop, and a haven from the southeast’s challenges. I initially went to university to become a medical doctor, a common path for bright kids in my small hometown. But a few teaching professors saw something different in me a curiosity that thrives in lab rats like us My fascination shifted from treating sniffles to marveling at the miracles of our bodies. I’ll never forget an 8 a.m. lecture on fish parasites delivered with the enthusiasm of a Carnegie Hall performance. That passion led me to study bird habits from the Carolinas to the Amazon and later to explore the intricate dance of cells different scales, same cosmic rhythm.
Describe the decision process that brought you to join UVa.
I wanted to be in a place where the community was healthy enough that people actually spent their lives with each other - apart from the things we do in lab, had a Cell Biology department that cared deeply about cells that were not residents of the skull, and I wanted folks nearby with extraordinary expertise in all the biophysical approaches I have relied on others for throughout my training. It also helped that there was a rich cohort of individuals that like to think about lipids and the oily bits of life that scramble about the delimitation of individuals that make up “us”.
From left to right:
Gwen Wagner, Jarred Whitlock, Hong-Yin Wang
Ming-Feng Tsai, Ph.D. Associate Professor
NEW FACES
PhD: University of Missouri Postdoc: Brandeis University
Where are you from and how did you become interested in becoming a researcher?
I’m originally from Taiwan and trained as a medical doctor at National Yang-Ming University. I joined their MD-PhD program, which took me to the University of Missouri for a PhD under TC Hwang, where I studied the CFTR Cl- channel using electrophysiology Ionchannel research captivated me due to its blend of physics, mathematics, and translational potential, prompting me to shift from clinical practice to scientific discovery. For postdoctoral training, I joined Christopher Miller’s lab at Brandeis University, where I deepened my expertise in membrane-transport biophysics and membrane-protein analysis The experience was both professionally rewarding and personally enriching, reinforcing my commitment to research. In 2019, I began my own lab at the University of Colorado School of Medicine.
Describe the decision process that brought you to join UVa. After starting my lab, we focused on mitochondrial calcium transport proteins, which regulate energy production and calcium-dependent processes like heart contraction, hormone secretion, and neurotransmission. Our goal is to uncover their molecular mechanisms and roles in cardiovascular health and disease, with an eye toward new therapeutics. MPBP at UVA offers a unique environment, bringing together world-class membrane biophysicists for molecular studies and cardiovascular physiologists for translational research This synergy makes U the perfect place for our lab to grow, and relocating here is an exciting step forward fo our research.
From left to right:
Po-Hsuan Lai, Hsuan-Yu Lin, YungChi Tu, Yu-Chen Chang, I-Chi Lee, YuLun Huang, Tsung-Yun Liu, and MingFeng Tsai
“MPBP at UVA offers a unique environment, bringing together world-class membrane biophysicists for molecular studies and cardiovascular physiologists for translational research.”
NEW FACES
Lu Gan, Ph.D.
LU GAN, PH.D.
“Our immediate goal is to explore how cells generate diverse nucleosome structures, which regulate gene expression, and inspire new methods to control it.”
Associate Professor
PhD: Scripps Research Institute
Postdoc: California Institute of Technology
Where are you from and how did you become interested in becoming a researcher?
Born in China and raised in the US, my passion for structural and cellular biology was shaped by my scientist parents and a love of science fiction During my PhD with Jack Johnson at The Scripps Research Institute, I explored bacteriophage capsid maturation in vitro. As a postdoc with Grant Jensen at Caltech, I used cryo-electron tomography to study bacterial cell walls and plankton chromosomes at ~4 nm resolution, revealing the potential for 3D molecular investigation of cellular processes. In 2011, I established my lab at the National University of Singapore, where my team studied chromosome structure using yeast and human cells, focusing on nucleosomes the 10 nm x 6 nm cylindrical complexes that organize ~150 base pairs of DNA.
Describe the decision process that brought you to UVA. The Department focuses on understanding biology across scales, from atoms to organisms. MPBP fosters collaboration among labs with shared interests in 3D regulation of cellular processes. UVA School of Medicine’s borderless structure enables basic researchers like me to collaborate freely with scientists and physicians studying human diseases. UVA has also invested heavily in advanced cryo-electron tomography infrastructure. These strengths made MPBP at UVA an ideal choice to expand my lab’s research into 3D mechanisms of gene regulation and misregulation in model organisms and cancers Our immediate goal is to explore how cells generate diverse nucleosome structures, which regulate gene expression, and inspire new methods to control it.
From left to right:
Vaishnavi Kishore, Jermaine Han, Claris Chong, Zhi Yang Tan, Lu Gan, Jon Chen, Tingsheng Liu, Christina Byun
NEW FACES
BROOKE O'DONNELL, PHD RESEARCH ASSOCIATE, ISAKSON LAB
WERE THERE ANY PARTICULAR FACULTY MEMBERS OR RESEARCH PROJECTS THAT ATTRACTED YOU TO UVA?
I decided to pursue a postdoc at UVA because of the distinguished researchers and research programs present at this institution. More specifically, because of my supervisor Dr. Brant Isakson, who is just one of many leaders in the vascular biology field within MPBP and the Robert M. Berne Cardiovascular Research Center. I met Brant at a conference back in 2019 and was always very interested in his lab’s research on pannexins in the vasculature. I have a background in pannexins in cancer, but was drawn to the cardiovascular field due to the driving role of the vasculature in the progression of many disease states, including cancer. Joining Brant’s lab is providing me the opportunity to broaden my research interests and train in a field that is entirely new to me.
How do you hope to contribute to the department during your time here?
I received my Ph.D. in Anatomy and Cell Biology at the University of Western Ontario in Canada, where I studied the biochemistry and function of pannexins and their isoforms in normal skin health and cutaneous cancers. My Ph.D. training was focused on molecular physiology, cell biology and biochemistry techniques as well as mouse models of cancer, and so during my time at UVA I hope to help bridge the gap between what we see physiologically at the organismal level and the mechanism of action at the cellular and signalling level. I also hope to bring a fresh perspective to this department in merging cancer and vascular research.
“I hope to help bridge the gap between what we see physiologically at the organismal level and the mechanism of action at the cellular and signalling level. I also hope to bring a fresh perspective to this department in merging cancer and vascular research.”
NEW FACES
“I chose UVA for its collaborative and innovative research environment, particularly within the Department, which bridges biophysics and physiology. The department’s emphasis on professional development through workshops, seminars, and career programs was highly appealing.”
HUILUN (HELEN) WANG, PHD RESEARCH ASSOCIATE, QI LAB
WHAT INSPIRED YOU TO JOIN UVA AND THE QI LAB FOR YOUR POSTDOCTORAL TRAINING?
I chose UVA for its collaborative and innovative research environment, particularly within the Department, which bridges biophysics and physiology. The department’s emphasis on professional development through workshops, seminars, and career programs was highly appealing Dr Qi’s mentorship was also a key factor—his insightful guidance, encouragement of intellectual curiosity, and supportive environment made his lab an ideal place for me to grow into an independent researcher.
How has your time at UVA shaped your research or professional growth?
Over the past year, I’ve collaborated with outstanding researchers across disciplines, enriching my perspective on scientific questions. For example, I’ve worked closely with labs within and outside the department on alternative splicing and neurophysiology research. These experiences, along with UVA’s resources like workshops and training programs, have enhanced my critical thinking and communication skills.
What advice would you give to new postdocs joining UVA?
HELEN WANG, PH.D. RESEARCH ASSOCIATE QI LAB
Make the most of UVA’s collaborative research environment and postdoc community. Engage actively, seek out opportunities to network, and connect with colleagues across labs they offer unique insights that can elevate your work
HANNAH CANNON GRADUATE STUDENT, LEVENTAL-KENWORTHY LAB
NEW FACES
I joined the Biomedical Sciences (BIMS graduate program in Fall 2023 after graduating from Virginia Tech with a bachelor’s in Biochemistry. The BIMS program interested me because of the wide range of research available and faculty spread across many departments. Although I was initially unsure about where my research interests lie, I quickly started taking interest in the Biophysics program and became passionate about answering fundamental questions in biology.
My joint mentorship between the Levental and Kenworthy labs has provided an excellent blend of protein biochemistry, cell biology, and membrane biophysics that has captured my interests and expanded my skills. On top of that, Anne, Ilya, and Kandice are exceptional mentors that I feel lucky to have during my graduate studies Their
“My joint mentorship between the Levental and Kenworthy labs has provided an excellent blend of protein biochemistry, cell biology, and membrane biophysics that has captured my interests and expanded my skills.”
HANNAH CANNON, BIOPHYSICS GRADUATE STUDENT, LEVENTALKENWORTHY LAB
From left to right:
Mackenzie Pham, Shikha Dagar, Emma Guo, Eve Cai, Daryna Sputay, Hannah Cannon, Carolyn Shurer, Luis Real Hernandez, Tyler Reagle, Hongyin Wang, Kandice and Ilya Levental, Snoop (bottom)
Department Retreat 2024 ACTVITIES
The Department held a successful student-led retreat on October 3, 2024, with over 100 trainees and faculty participating. The event featured a variety of presentations and discussions, aimed at fostering collaboration and professional development. Highlights included student presentations, insights from new faculty members, and roundtable discussions on topics such as graduate school, career pathways, and postdoctoral opportunities. The format encouraged lively dialogue and idea sharing.
The retreat, led by Dr. Ilya Levental, was organized by dedicated graduate students and included awards for exceptional student achievements. The department looks forward to building on the momentum from this event to continue fostering a collaborative and innovative environment.
MPBP Postdoctoral Association
Founded in 2023, the MPBP Postdoctoral Association is led by postdoctoral fellow Dr Helen Wang and faculty advisor Dr Ahmad Jomaa, dedicated to fostering a vibrant and inclusive community. The mission is to strengthen communication, engagement, and diversity among postdocs while promoting connections with faculty members and peers. It strives to create a supportive environment that offers valuable resources for career development and smooth transitions to the next stage of professional growth. Additionally, it serves as a platform to celebrate and highlight the achievements and contributions of our postdocs
Tamm Postdoctoral Research Award
Presented to Leo Lin by Dr Ling Qi @ 2024 MPBP Postdoc Symposium.
"Our MPBP research fellows thrive in a collaborative environment, striving for excellence in both research and innovation."
Postdoctoral Association montly meeting
Postdoctoral Association
Poster session
AHMAD JOMAA, PH D ASSISTANT PROFESSOR, FACULTY ADVISOR FOR MPBP POSTDOCTORAL ASSOCIATION
MPBP SPEARHEADED THIS POSTDOC VIDEO AVAILABLE ON YOUTUBE
2024 Winter Holiday Dinner
Postdoctoral Association Committee
Dr Xiaoqiong Wei, Dr Yinghui Wang, Dr Mauricio Torres, Dr Carolyn R Shurer, Dr Helen Wang, Dr Preeti Verma, Dr Ling Qi, Dr Ahmad Jomaa (Faculty Advisor)
ACTVITIES
“Inspiring even one student to develop a lifelong passion for science makes the program incredibly rewarding. This program is a wonderful way to give back to the community and inspire the next generation of scientists.”
Community Outreach
Starr
Led
Hill
Pathways Program
by Dr. Stefanie
Redemann
The Starr Hill Pathways Program, an initiative by the UVA Equity Center, is dedicated to providing college and career exploration opportunities to Charlottesville area youth from low and middle-income backgrounds. In 2024, our department collaborated with the medical departments to offer students a comprehensive look into medical sciences, including clinical practice and laboratory science.
During a two-week period, students from the Starr Hill Program visited several different labs within our department. They were introduced to our research and engaged in hands-on ities, such as expressing fluorescent proteins, working with various model organisms, and learning about the scientific method and experimental design. These experiences allowed students to spend a short but impactful time in each lab, sparking their curiosity and passion for science.
We encourage everyone in our department to get involved in this year's program. Your participation can help these young scholars explore diverse career pathways and build a brighter future. By supporting this initiative, we not only contribute to the community but also serve as role models and mentors, fostering a love for science and learning in the next generation.
2023
DEC 8TH, 2024
DEC 7TH, 2024
Monthly Departmental Programs
Department Seminars
Every Monday throughout the academic year. Featuring invited guest scientists from other Universities and Institutions. Provides introductions to colleagues for collaboration, and opportunities for trainees to meet and greet scientists from around the country and around the world.
Faculty Meetings
4th Wednesdays of the Month
Postdoctoral Association Meetings
2rd Friday of the Month
Research in Progress, Center for Membrane & Cell Physiology
First Thursdays of the Month; Trainees from CMCP labs present their Research to department faculty, and fellow trainees.
First Friday Faculty Research In Progress (RIP)
Presentations among MPBP faculty focused on research and grant submissions, unpublished work, or the sharing of experience with a grant that just received a perfect or near perfect score.
Departmental Work In Progress (WIP)
Starting in Feburary, 2025, every 4th Thursday of the month, the department will gather for presentations by both Physiology labs and Biophysics labs with a Q&A followed by a social hour.
“Your support will drive groundbreaking research, train the next generation of scientists, and advance medical discoveries that improve lives.”
“Join us today in shaping the future—every contribution makes a difference!”
How to Send Your Financial Support to the Department of Molecular Physiology and Biological Physics
We need your support for our mission in research and education. Please consider donating to our department general fund. Your generous gift is essential to maintaining excellence in our research programs and our efforts to train the next generation of scientists. A gift of our appreciation and notice of your tax deductible donation will be provided. To donate, just visit our website, go to the “Donate” page, and click “Give Today.” If you have any questions, please contact uvahealthgifts@virginia.edu or 434-924-8432.
Or just scan this QR code, it will take you to the donation page.
2024 HONOR ROLL SUPPORT
FEDERAL AGENCIES ($18.4 M)
NIH NHLBI
NIH NIDDK
NIH NCI
NIH NIBIB
NIH NIGMS
NIH NIAID
NIH NIA
NIH NICHD
FOUNDATIONS ($1.6 M)
Little Warrior Foundation Simons Foundation
Owens Foundation
Leducq Foundation for Cardiovascular Research
American Heart Association
American Society for Nephorology
Additional Ventures Foundation Alzheimer’s Association
American Federation for Aging Research
American Diabetes Association
National Ataxia Foundation
COMPANIES ($3,200)
Abclonal TSE systems
ThermoFisher
Heartfelt gratitude to our exceptional staff. Your dedication to managing finances, handling special projects, submitting grant applications, organizing seminars, and improving financial reporting is deeply appreciated. Your hard work and commitment are vital to our department's success. Thank you for your unwavering excellence.
Together, we advance the frontiers of science and make meaningful contributions to our field. Your efforts do not go unnoticed, and we are grateful for each of you.
PAM ACKER
DANIELLE KNIGHT
DUSKA BURRUSS
JENNIFER SMITH
ANN ADAMS
KIM PATE
MARK DANIELS
SAM HOLLAND
DepartmentNewsMagazine
Editedby: Dr.LingQi,DepartmentChair JenniferSmith,SpecialAssistanttotheChair
Reviewedby:Drs.GloriaSheynkman,JochenZimmer,&otherMPBPmembers
Approvedby:BarryCollins,UVASchoolofMedicine,ExecutiveDirectorof UVAMedicalAlumniAssociationandMedicalSchoolFoundation
DebHepp,SpecialAssistanttotheDean,UVASchoolofMedicine
Published: February,2025
Credited to Jason Li, Biophysics MSTP student