Office of Research - Faculty Retreat

2024 School of Medicine Faculty Research Retreat

EMERGING APPROACHES & BIOTECHNOLOGIES

Friday, February 2 & Saturday, February 3 The Forum Hotel, UVA Darden

FRIDAY, FEBRUARY 2 2:30-2:45

Welcome to the 2024 Faculty Research Retreat

Ballroom

Melina Kibbe, MD, Dean, UVA School of Medicine Jeff Martens, PhD, Senior Associate Dean for Research Mary Peace McRae, PharmD, PhD, Assistant Dean for Research

2:45-4:30 Melina Kibbe, MD UVA School of Medicine Dean

Ian Baucom, PhD UVA Executive Vice President and Provost

SCHOOL OF MEDICINE OFFICE FOR RESEARCH

Jeff Martens, PhD Senior Associate Dean for Research

Mary Peace McRae, PharmD, PhD Assistant Dean for Research

RESEARCH ADVISORY COMMITTEE Isabelle Derre, PhD • Associate Professor, Microbiology, Immunology, & Cancer Biology John Fu, PhD • Associate Professor, Pharmacology Alban Gaultier, PhD • Associate Professor, Neuroscience Fern Hauck, MD • Professor, Family Medicine Scott Heysell, MD • Associate Professor, Medicine/Infectious Diseases Karen Hirschi, PhD • Professor, Cell Biology Hao Jiang, PhD • Professor, Biochemistry & Molecular Genetics Peter Kasson, MD, PhD • Professor, Molecular Physiology & Biological Physics Kwon-Sik Park, PhD • Associate Professor of Microbiology, Immunology, & Cancer Biology Jennifer Payne, MD • Professor, Psychiatry & Neurobehavioral Sciences Swapnil Sonkusare, PhD • Associate Professor, Molecular Physiology & Biological Physics Anne Sperling, PhD • Professor, Medicine/Pulmonary & Critical Care Bradford Worrall, MD • Professor, Neurology

Biomedical Applications of Artificial Intelligence

Ballroom

Immerse yourself in the world of Artificial Intelligence through sessions that unveil the transformative power of AI in biomedical applications. Explore topics ranging from accessing AI infrastructure to precision medicine and computational modeling, fostering discovery in the ever-evolving landscape of biomedical engineering.

Moderator: Joe Mychaleckyj, PhD, Professor, Public Health Sciences Josh Baller, PhD, Associate Vice President for Research Computing, “Accessing AI Infrastructure and Expertise through Research Computing’s Data Analytics Center” Jason Papin, PhD, Professor, Biomedical Engineering, “Catalyzing Discovery in Biomedical Engineering with Computational Modeling” Sana Syed, MD, Associate Professor, Pediatrics, “From Data to Diagnosis: How Artificial Intelligence is Paving the Way for Precision Medicine in IBD” Aidong Zhang, PhD, Professor, Biomedical Engineering, “Explainable and Robust Deep Learning Approaches for Biomedical Applications”

4:30-5:30

Presentations by Pinn Scholars

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Current and past Pinn Scholars will provide brief updates on their projects. Gain insights into the impactful research journeys of our esteemed scholars.

H erve Agaisse, PhD, Professor, Microbiology, Immunology & Cancer Biology, “Post-Epithelial Phase in Shigellosis” Andrew Dudley, PhD, Professor, Microbiology, Immunology & Cancer Biology, “Blood Vessel Remodeling by Melanoma Cells During Perivascular Invasion in the Brain” Tajie Harris, PhD, Associate Professor, Neuroscience, “T Cell ‘Selection’ in the Brain” Peter Kasson, MD, PhD, Professor, Molecular Physiology & Biological Physics, “Physical Constraints on the Evolution of Viral Entry” Hui Zong, PhD, Professor, Microbiology, Immunology & Cancer Biology, “Investigate Immune Surveillance Against Triple Negative Breast Cancer”

5:30-7:00

Reception and Poster Session

Oak Boardroom & Academy Room

Enjoy refreshments and connect with colleagues at our reception and poster session.

Explore a diverse array of research projects presented by both established and newer members of the SOM, including directors of core facilities. This is a fantastic opportunity to mingle, share insights, and potentially find future collaborators within our vibrant research community.

Faculty Posters

Antonio Abatte, MD, PhD, Professor, Medicine/Cardiovascular 3

Daniel Abebayehu, PhD, Assistant Professor, Biomedical Engineering Sameer Bajikar, PhD, Assistant Professor, Cell Biology Huan Bao, PhD, Associate Professor, Molecular Physiology & Biological Physics Matthew Devall, PhD, Research Assistant Professor, Family Medicine Sepideh Dolatshahi, PhD, Assistant Professor, Biomedical Engineering Seham Ebrahim, PhD, Assistant Professor, Molecular Physiology & Biological Physics Patrick Finan, PhD, Professor, Anesthesiology Marilyn Huang, MD, Professor, Obstetrics & Gynecology Lulu Jiang, MD, PhD, Assistant Professor, Neuroscience Ahmad Jomaa, PhD, Assistant Professor, Molecular Physiology & Biological Physics Timothy Layng, DO, Assistant Professor, Emergency Medicine Wenpeng Liu, PhD, Assistant Professor, Radiation Oncology Tsai-Yi Lu, PhD, Assistant Professor, Neuroscience Timothy Martin, PhD, Assistant Professor, Pharmacology Laura Newman, PhD, Assistant Professor, Cell Biology Shengyi Iris Sun, PhD, Associate Professor, Pharmacology Shangming Tang, PhD, Assistant Professor, Biochemistry & Molecular Genetics Monique Vaughan, MD, Assistant Professor, Obstetrics & Gynecology Paul Viscuse, MD, Assistant Professor, Medicine/Hematology & Oncology Ian Wenker, PhD, Assistant Professor, Anesthesiology Daniel Zegarra-Ruiz, PhD, Assistant Professor, Microbiology, Immunology & Cancer Biology Tian Zhang, PhD, Assistant Professor, Biochemistry & Molecular Genetics Lisa Zuckerwise, MD, Associate Professor, Obstetrics & Gynecology Core Facility Posters

Advanced Microscopy Facility, Sijie Hao, PhD, Director Bioinformatics Core, Pankaj Kumar, PhD, Director Biomolecular Analysis Facility, Nicholas Sherman, PhD, Director Biomolecular Magnetic Resonance Facility, Jeff Ellena, PhD, Director Biorepository and Tissue Research Facility, Pat Pramoonjago, PhD, Director Center for Human Therapeutics cGMP Facility, Archana Thakur, PhD, Director Exercise Physiology Core Laboratory, Lisa Farr, MEd, Director Flow Cytometry Core Facility, Mike Solga, MS, Director Genetically Engineered Murine Model Core, Wenhao Xu, PhD, Director Genome Analysis and Technology Core, Katia Sol-Church, PhD, Director Genome Engineering Shared Resource, Brian Ruis, MS, Director Molecular Electron Microscopy Core, Michael Purdy, PhD, Director Molecular Imaging Core, Maurits Jansen, PhD, Director Molecular Immune Translational Science Core, Ileana Mauldin, PhD, Director Radiochemistry Core, Shivashankar Khanapur, PhD, Director Research Histology Core, Sheri Vanhoose, Director Spatial Biology Core, Ana Karina de Oliveira, PhD, Director 4

SATURDAY, FEBRUARY 3 7:30-8:00

Continental Breakfast

8:00-9:30

Concurrent Sessions

Lobby

Precision Health: Public, Clinical Treatment, and Diagnostics

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Explore diverse perspectives on precision health applications, from immunology and public health policies to autism research and genetic insights into coronary artery disease risk.

Moderator: Jennifer Payne, MD, Professor, Psychiatry Kate McManus, MD, Assistant Professor, Medicine/Infectious Diseases, “Ending the HIV Epidemic: Evidence About Health Policies in Practice” Coleen McNamara, MD, Professor, Medicine/Cardiovascular, “Immunology, Imaging and Informatics for Precision ImmunoMedicine (iPRIME)” Clint Miller, PhD, Associate Professor, Public Health Sciences, “Genetic and Cellular Determinants of Coronary Artery Disease Risk” Kevin Pelphrey, PhD, Professor, Neurology, “Toward Precision Health in Autism(s)” Collaboration Across Grounds

Washington Room

Explore collaboration opportunities across Grounds through interdisciplinary connections that can elevate your work and open doors to new research possibilities.

Catherine Bradshaw, PhD, Associate Dean for Research, School of Education Don E. Brown, PhD, Senior Associate Dean for Research and Quantitative Foundation, School of Data Science Laura Galloway, PhD, Associate Dean for the Sciences and Research, College of Arts and Sciences Brian Smith, PhD, Interim Associate Dean for Research, School of Engineering and Applied Science

9:30-10:00

Break

10:00-11:30

Concurrent Sessions

Emerging Approaches & Biotechnologies: Genetics, Genomics, Proteomics

Lobby

Ballroom

Unlock the versatility of -omics approaches, from gene regulation to personalized medicine and public health applications. Speakers will reveal findings and explore collaborative applications of cutting-edge -omics approaches.

Moderator: Hao Jiang, PhD, Professor, Biochemistry & Molecular Genetics Sarah Flowers, PhD, Assistant Professor, Neuroscience, “Applications and Clinical Significance of Quantifying Carbohydrate Post-Translational Modifications” Keith Keene, PhD, Professor, Public Health Sciences, “Integrating Genomics and Public Health Approaches to Address Health Inequities” Gloria Sheynkman, PhD, Assistant Professor, Molecular Physiology & Biological Physics, “Towards Proteoform Medicine: New Technologies for Patient-Specific Proteomics” Chongzhi Zang, PhD, Associate Professor, Public Health Sciences, “Single-Cell and Spatial Omics Technologies and Computational Approaches for Gene Regulation” 5

Large and Complex Grants: P and U Type Awards

Washington Room

These faculty will share their experiences and then engage in a panel discussion about the application process, including do’s and don’ts for successful applications.

Moderator: Kim Mayer, PhD, Associate Vice President for Research Development Doug Bayliss, PhD, Professor, Pharmacology Brant Isakson, PhD, Professor, Molecular Physiology & Biological Physics Todd Stukenberg, PhD, Professor, Biochemistry and Molecular Genetics James Zimring, MD, PhD, Professor, Pathology

11:30-1:30

Lunch and Shark Tank Competition

Ballroom

Get ready for an exhilarating afternoon! Grab your lunch, find your seats, and join us at noon for the Shark Tank-style competition. Five teams will pitch innovative ideas targeting large and complex (P&U level) grants. With three expert judges in the hot seat and the audience casting their votes, witness the dynamic pitches and strategic maneuvers as these teams compete for incentive funds to support their journey in assembling groundbreaking grant proposals.

Shark Tank Presentations

Lead PI: Ukpong Eyo, PhD, Associate Professor, Neuroscience, “Glial Dysfunction as Drivers of Neurodegeneration in Alzheimer’s Disease” Lead PI: Loren Erickson, Associate Professor, Microbiology, Immunology & Cancer Biology, “Immune Mechanisms of IgE Sensitization to Alpha-Gal” Lead PI: Alex Kuan, MD, PhD, Professor, Neuroscience, “Epilepsy in the Elderly and Alzheimer’s Disease” Lead PI: Jennifer Payne, MD, Professor, Psychiatry and Neurobehavioral Sciences, “Postpartum Depression Research & Training Center” Lead PI: Coleen McNamara, MD, Professor, Medicine/Cardiovascular, “The Impact of G6PDDeficiency on Common Diseases of Global Significance”

Presentations by Pinn Scholars

Ballroom

Find out more about the Pinn Scholars’ ongoing and completed projects.

Mark DeBoer, MD, Professor, Pediatrics, “MAL-ED Metabolic: Early Life Associations with Chronic Disease Risk” Hao Jiang, PhD, Professor, Biochemistry & Molecular Genetics, “Understanding and Targeting Nuclear Condensates in Disease” Hui Li, PhD, Professor, Pathology, “Genome-Wide Study of Chimeric RNAs and Their Implication in Colorectal Cancer” Ani Manichaikul, PhD, Associate Professor, Public Health Sciences, “Building a Program in Single Cell Genomics of Lung for Studies of COPD and Emphysema” Sean Moore, MD, Professor, Pediatrics, “It Takes Guts to Grow: The First 1000 Days”

2:30-3:00 6

Break

Concurrent Sessions

Emerging Approaches and Biotechnologies: Imaging

Ballroom

Discover research insights as speakers share findings and collaborative applications of cutting-edge imaging approaches. Engage in a post-talk panel discussion to explore the transformative potential of imaging in biotechnological innovation.

Moderator: Karen Hirschi, PhD, Professor, Cell Biology Edward Nieh, PhD, Assistant Professor, Pharmacology, “Playing the Brain Like a Piano­— Manipulating Neural Manifold Trajectories with 2-Photon Stimulation” Natasha Sheybani, PhD, Assistant Professor, Biomedical Engineering, “Image-Guided Focused Ultrasound Interventions for Next-Generation Cancer Immunotherapy” Joshua Wythe, PhD, Associate Professor, Cell Biology, “Using 3D Imaging Technologies to Advance Our Understanding of Diseases Affecting the Cerebrovasculature” Jochen Zimmer, PhD, Professor, Molecular Physiology & Biological Physics, “Imaging Bacterial Encapsulation From Single Particles to Cells” Research Commercialization

Judges: Karen Johnston, MD, Professor, Neurology, Gary Owens, PhD, Professor, Molecular Physiology & Biological Physics, Kevin Janes, PhD, Professor, Biomedical Engineering

1:30-2:30

3:00-4:30

Washington Room

Learn how our SOM translational research programs and UVA Licensing & Ventures Group bridge the gap between scientific discoveries and practical applications. Explore funding paths through internal and regional mechanisms and engage in an interactive session with a faculty panel sharing their experiences and successful approaches in navigating research commercialization challenges.

Moderator: Sharon Krueger, Director of Innovation Grants and Relationships, School of Medicine UVA Licensing & Ventures Group Rich Chylla, PhD, Executive Director, UVA Licensing & Ventures Group Bob Creeden, MBA, Managing Director, UVA LVG Seed Fund & New Ventures Matt Rannals, PhD, Venture Associate, UVA Licensing & Ventures Group Research Commercialization Translational Research & Commonwealth Resources David Chen, MS, MBA, Managing Director, Coulter Center for Translational Research Sharon Krueger, MS, Director of Innovation Grants and Relationships, School of Medicine Panel Discussion Tom Barker, PhD, Professor, Biomedical Engineering John Lazo, PhD, Professor, Pharmacology and Chemistry Manoj Patel, PhD, Professor, Anesthesiology Rahul Sharma, PhD, Associate Professor, Medicine/Nephrology

4:30-6:00

Reception and Shark Tank Winners Announcement!

Lobby

Cap off the Faculty Research Retreat at a reception where we will reveal the triumphant winners of the Shark Tank Competition.

Lobby

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SCHEDULE AT A GLANCE Friday 2:30-2:45 2:45-4:30 4:30-5:30 5:30-7:00

Welcome Biomedical Applications of Artificial Intelligence Pinn Scholar Presentations Reception and Poster Session

Saturday 7:30-8:00 8:00-9:30 10:00-11:30 11:30-1:30 1:30-2:30 3:00-4:30 4:30-6:00

Continental Breakfast Concurrent Sessions Concurrent Sessions Lunch and Shark Tank Competition Pinn Scholar Presentations Concurrent Sessions Reception and Shark Tank Winners

ONLINE AGENDA

ABOUT THE PINN SCHOLARS The Pinn Scholars Program, named after Dr. Vivian Pinn, a distinguished graduate of the University of Virginia School of Medicine and the first director of the NIH Office of Research on Women’s Health, aims to acknowledge and reward research faculty. Individuals selected to be Pinn Scholars demonstrate exceptional scientific expertise, productivity, mentorship, and service, leading to significant contributions to both the School of Medicine and the broader research community.

Each year, up to three scholars are selected to receive funds for advancing their scientific pursuits and to participate in a research symposium.

2024 RETREAT GOALS FOSTER COLLABORATION Explore colleagues’ research for potential synergy and build new collaborations CREATE A WELCOMING ENVIRONMENT for recently joined SOM faculty members