CRUCES ÁNGELES
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INGENIERÍA AMBIENTAL foto: www.pexels.com
TRIOSAFOSFATO ISOMERASA
María Eugenia Cruces Ángeles1 1 Tecnológico de Estudios Superiores del Oriente del Estado de México. División de Ingeniería Ambiental, Paraje de San Isidro S/N, Barrio de Tecamachalco, 56400, Los Reyes Acaquilpan, Estado de México.
ABSTRACT: Triosephosphate isomerase (TIM) is considered as a stable homodimer, although the catalytic residues are present in each monomer, the enzyme activates only in its dimeric form, the reasons for this oligomeric nature remain unclear. It is a ubiquitous enzyme, there are many TIM present in both from prokaryotes to eukaryotes organisms. Most TIMs studied come from parasitic sources, this may be due to the impact of parasites in human health., this is probably due to the impact of these parasites on human health. TIM plays an important role in several metabolic pathways, and it is essential for the efficient energy production, Because of this, it has been considered as the target in the design of drugs that may act against the enzyme of parasites located in the blood of mammals, where they consume the available glucose, causing diseases such as malaria and trypanosomiasis [Goméz-Puyou et al., 1995; Tellez-Valencia, et al., 2002]. Deficiencies in human TIM, caused by mutations, produce an increase in levels of DHAP,wich generate (with a simple point mutation (I170V)) chronic hemolytic anemia (Orosz et al., 2009); The E104D mutation produces a serius progressive neurological disorder (Rodríguez-Almazán et al., 2008). Keywords: TIM, G3P, DHAP, ubiquitous, mutation.
J U L I O - D I C I E M B R E 2 0 1 8 | T E S T L A PA L L I
