FUNCTIONAL INGREDIENTS
An ideal probiotic for a healthy gut microbiome Probiotics are microbial preparations that beneficially affect the host by improving intestinal microbial health1.
T
he gut microbiome is associated
supplementation with B. coagulans MTCC 5856
with a number of chronic illnesses2
(2x10⁹ CFU/day) demonstrated a clinically
such as obesity, insulin resistance,
significant decrease in body weight, BMI and
high cholesterol, inflammation, blood sugar,
waist circumference. Additionally, pre-post
colorectal cancer, Crohn’s disease, ulcerative
intervention decreased the levels of total
colitis, celiac disease, allergies, and chronic
cholesterol, LDL cholesterol and triglycerides7.
fatigue syndrome.
This probiotic was found to be stable
Research suggests that consumption
during baking and storage at frozen
of probiotics is associated with a range of
conditions of banana muffins (92% viability)
health benefits, including maintaining the
and waffles (86% viability) up to 12 months.
structural and functional integrity of the gut,
vomiting, diarrhoea, abdominal pain, and stool
After brewing coffee at 90°C for two minutes
immune support, protection against diarrhoea,
frequency compared to placebo (Fig. 1A and
there was 87% viability and retained
providing nutritional benefits to the host and
1B). Additionally, decreased disease severity
66% viability even after maintaining the
preventing the growth of harmful bacteria.
(i.e. Physician’s global assessment) and better
temperature at 77°C for 4.0h.
According to Stokes and Pillsbury, emotional state might alter the normal
It showed over 95% viability in chocolate
IBS quality of life was seen in the B. coagulans MTCC 5856 group (Fig. 1C and 1D)5.
fudge frosting, hot fudge toppings, peanut
intestinal microflora, increase intestinal
butter, strawberry preserve and vegetable
permeability and contribute to systemic
oil at room temperature up to 12 months.
inflammation3. Small intestinal bacterial
It was found to be stable in apple juice up
overgrowth (SIBO) is closely associated with
to six months at refrigerated condition and
depression and anxiety.
concentrated glucose syrup at 4±3 and 25±2°C
Sabinsa’s LactoSpore (Bacillus coagulans
up to 24 months. It showed promising stability
MTCC 5856) is a shelf-stable gram-positive
during processing and storage of functional
bacteria that produces only L (+) lactic acid.
foods and could be an excellent probiotic
In a double-blind, placebo-controlled study,
ingredient to use in various food applications.
30 day supplementation of B. coagulans MTCC
In conclusion, LactoSpore, Bacillus
5856 (2x10⁹ CFU/day) was found to be safe and
coagulans MTCC 5856 is suitable in various food
well-tolerated in healthy adults (n=40) when
preparations and has multiple health benefits. •
given orally4. In another double-blind, randomised, placebo-controlled study, 36 subjects diagnosed with diarrhoea-predominant irritable bowel syndrome (IBS-D), received B. coagulans MTCC 5856 (2x109 CFU/day) or placebo for 90 days. B. coagulans MTCC 5856 group showed a significant decrease in clinical symptoms, such as GI discomfort, bloating,
Physician’s global assessment (C) and Quality of Life score (D) in IBS subjects
In continuation of the above study, 20 adults with IBS co-existing with major depressive disorder (IBS-MDD) were given B. coagulans MTCC 5856 and another 20 subjects were on placebo. At 90 days, subjects receiving B. coagulans MTCC 5856 reported a significant change in their depression along with a decrease in IBS, improvement in sleeplessness as compared to subjects receiving placebo. Hence, B. coagulans MTCC 5856 effectively improves the gut microbiome by suppressing the growth of pathogens like E. coli and Visual Analog Scale for abdominal pain (A) and Bristol Stool Score for stool frequency (B) in IBS subjects.
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Food Review | April 2020
Gibson GR and Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotic. J Nutr. 1995 Jun;125(6):1401-12. 2 Stokes JH and Pillsbury DM. The effect on the skin of emotional and nervous states: I II. Theoretical and practical consideration of a gastro-intestinal mechanism. Arch. Derm. Syphilol. 1930, 22: 962–93. 3 Vaillancourt, J. Ending the war metaphor: the changing agenda for unravelling the host-microbe relationship. Regulating pre- and probiotics: A U.S. FDA perspective. Institute of Medicine of the National Academies. National Academies Press; Washington, DC: 2006. p. 229-37. 4 Majeed et al. A double-blind, placebo-controlled, parallel study evaluating the safety of Bacillus coagulans MTCC 5856 in healthy individuals. J Clin Toxicol. 2016, 6(1):1–9. 5 Majeed et al. Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant irritable bowel syndrome: a double blind randomized placebo controlled pilot clinical study. Nutr J. 2016; DOI: 10.1186/s12937-016-0140-6. 6 Majeed et al. Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double blind, placebo controlled, multi-centre, pilot clinical study. Food & Nutrition Research. DOI: https://doi.org/10.29219/fnr.v62.1218 7 Balliett M and Burke JR. 2013. Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients participating in a low-energy dietary intervention. Journal of Chiropractic Medicine 12:3–14. 8 Majeed et al., 2016. Evaluation of the stability of Bacillus coagulans MTCC 5856 during processing and storage of functional foods. International Journal of Food Science and Technology. doi:10.1111/ijfs.13044. 1
Salmonella, which are the root cause of IBS6. In a 21-day weight loss programme with pre-post intervention design, regimented
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