Marchesini Group_Primary Packaging

PRIMARY PACKAGING

Designed to secure pharma products safely

Packaging solutions inspired by the extraordinary

Index ABOUT MARCHESINI GROUP..................................................4 KEYPOINT................................................................................5 ORAL SOLID DOSE...................................................................6 Tablet counting.......................................................................6 Blister....................................................................................11 Strip Pack..............................................................................17 Rigid Tube..............................................................................19 Under containment...............................................................20 LIQUIDS..................................................................................22 Stickpack...............................................................................22 Sachet....................................................................................23 Bottles/vials..........................................................................25 CREAMS.................................................................................31 Squeezable tubes.................................................................31 Jar..........................................................................................33 POWDERS..............................................................................34 Stickpack...............................................................................34 Sachet....................................................................................35

OUR PRODUCTION PLANTS

We at Marchesini Group are proud leaders in manufacturing and integrating complete lines since 1974.

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We produce stand-alone machines and complete lines to handle the entire packaging process for the pharmaceutical industries. Today, the Marchesini Group caters for the whole packaging process of pharmaceuticals, from start to finish.

It creates stand-alone machines and complete lines to package products such as vials, syringes, carpules, bottles and blisters through to putting the individual products into bundles, cases and on pallets.

The finished product - machines capable of packaging all kinds of pharmaceutical products - is a combination of craftsmanship integrated with robotics and technology.

This result has been achieved thanks to the expertise of the Group’s production plants which specialize in designing and manufacturing packaging machines with specific productive technologies, such as aseptic packaging, Blister packaging, Labelling, Inspection, all to manage every kind of pharmaceutical product, oral solid dose, liquid, cream or powder that can be put in every kind of pack.

The Group develops and manufactures specific machines for the whole packaging process in its plants mainly located throughout Italy, while complete line assembly is coordinated from our Headquarters.

Keypoint Industry 4.0 Compliant Our machines are designed in accordance

cGMP regulations with

and feature the

latest IoT technologies.

Our machines are designed

to reduce total changeover time

Small footprint to optimize the factory floor space.

and maximize performance.

New models are constantly developed in our

in-house R&D. department.

Our patented robotic solutions are developed

in-house to connect different machines together in-line.

Accessible and ergonomically designed machines ensure a positive operator experience in terms of

machine management, inspection and service.

We provide a

complete range of machines for the entire packaging process.

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ORAL SOLID DOSE

Tablet Counting COMPACT SERIES Featured Model COMPACT 24

Counting Filling and Capping monoblock machine for solids.

Monoblock machine for filling and capping bottles with tablets, capsules or pills.

On the Compact Series, innovation is put at the service of simplification in format change, to meet the increasingly pressing needs of maintaining the highest quality standards and performances, even in the presence of different products and counts in small or medium-sized batches.

To achieve this result, an innovative magnetic movement transport system was used (Compact24 model). It allows to overcome the typical limits of normal transport systems, by means of the totally autonomous handling of each single bottle: positioning, grouping, speed of movement are just some of the parameters that make this system unique.

• HIGHER production rates (Newer counting technologies enable higher bottle rates) • VERY FAST change-over times • HIGHER product quality (Complete control of the bottle, Pre or post checkweighing, High speed electronic counter, Rotary chuck capper) • MORE EFFICIENT floor space utilization TECHNICAL DATA MECHANICAL SPEED: Bottles-cycles/minute Tablet Ø (mm) Capsules size (A) (G)

• HIGHER equipment efficiencies (2D and 3D control for the product verification, HarleNIR system for the verification of the active principle contained in the product, Rejection system for the single no-compliant product, Dual head cotton feeding group, Desiccant feeding group)

COMPACT 12

COMPACT 24

COMPACT 36

COMPACT 12 VALIDA

COMPACT 24 VALIDA

COMPACT 36 VALIDA

Up to 75 5 - 20 000 - 5 from 18 to 90 mm from 35 to 180 mm

Up to 150 5 - 20 000 - 5 from 30 to 125 mm from 50 to 220 mm

Up to 200 5 - 20 000 - 5 from 30 to 125 mm from 50 to 220 mm

Up to 75 5 - 13 000 - 5 from 18 to 90 mm from 35 to 180 mm

Up to 150 5 - 13 000 - 5 from 30 to 125 mm from 50 to 220 mm

Up to 200 5 - 13 000 - 5 from 30 to 125 mm from 50 to 220 mm

“A” Diameter of round bottle. “G” Total bottle height, without closure.

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ORAL SOLID DOSE

Tablet Counting VALIDA SERIES Featured Model VALIDA

The main concept of this solution is the “VALIDATION” of the counting process.

VALIDA includes at least a 2D vision control, where 4 cameras placed immediately over the last vibrating tray, check shape, color and dimensions of travelling product; each tablet is univocally traced and followed up to its falling at the end of the tray.

VALIDA can includes a 3D control too. Thickness verification is obtained by a couple of special pattern projectors. A series of 12 gates are capable to intercept and reject a SINGLE bad product.

In addiction the Valida solutions can be equipped in the NIR Technology. It works within the region of the infrared frequency, where the molecules used in pharma production are highly reactive and show a well defined chemical footprint. This is also possible thanks to our innovative detection systems: in fact a normal camera acquires what it sees. An hyperspectral one instead does not take a single image, but several consecutive frames, which contain info related to the spectrum of each point of the product.

TECHNICAL DATA MECHANICAL SPEED: Bottles-cycles/minute Tablet Ø (mm) Capsules size (A) (G)

VALIDA 12

VALIDA 24

Up to 60 5 - 13 000 - 5 from 20 to 100 mm from 55 to 185 mm

Up to 120 5 - 13 000 - 5 from 20 to 110 mm from 55 to 185 mm

“A” Diameter of round bottle. “G” Total bottle height, without closure.

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ORAL SOLID DOSE

Tablet Counting SYNCHRO Featured Model SYNCHRO

Counting and capping monobloc for medium/high speeds, equipped with synchro-dynamic groups for the collection of the stopped count and the continuous transfer inside the bottles.

The transport is equipped with continuous motorized adjustment, to adapt to the different dimensions of the bottles. The capping unit is equipped with 8 heads, each with its own motor, for accurate control of the applied torque.

• The transfer of the product starts during the tracking of the bottle and therefore progressively, making use of all the available time/cycle. This system considerably reduces the criticality of product transfer through the neck of the bottle • Inside the monoblock, it is possible to integrate silica-gel feeding systems and/or cotton insertion systems

TECHNICAL DATA MECHANICAL SPEED: Bottles-cycles/minute Tablet Ø (mm) Capsules size (A) (G)

SYNCHRO 24

SYNCHRO 36

SYNCHRO 24 VALIDA

Up to 150 5 - 20 000 - 5 from 30 to 70 mm from 50 to 140 mm

Up to 220 5 - 20 000 - 5 from 30 to 70 mm from 50 to 140 mm

Up to 150 5 - 13 000 - 5 from 30 to 70 mm from 50 to 140 mm

“A” Diameter of round bottle. “G” Total bottle height, without closure.

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• The continuous transport of the bottles allows the use of a capping group which is also of the continuous type and therefore able to contain the necessary spaces, in addition to requiring a single channel for feeding the caps

ORAL SOLID DOSE

Tablet Counting ELECTRA Featured Model ELECTRA

Electro-mechanical counting unit for counting and checking of tablets, dragees and capsules at high speed.

Counting is done volumetrically, stacking products vertically in adjacent columns.

The system allows the installation of a vision system placed in front of the accumulation columns, which checks the shape, size and number of stacked products, immediately before their release.

Following the release, the same vision system checks the complete emptying of the counting channels.

The machine can fill up to 6 bottles at the same time, depending on the size of the bottle itself and the required count.

• Machine of extremely compact dimensions compared to the achievable production speeds • Vision check of product integrity and counting, with single bottle reject system in case of defective product or incorrect counting • Integrated upstream and downstream systems for sorting and subsequent grouping of bottles (up to 6 rows)

“A” Diameter of round bottle. “G” Total bottle height, without closure.

TECHNICAL DATA MECHANICAL SPEED: Bottles-cycles/minute Tablet Ø (mm) Capsules size (A) (G)

ELECTRA Up to 180 5 - 12 000 - 5 from 20 to 50 mm from 40 to 100 mm

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ORAL SOLID DOSE

Tablet Counting FTC SERIES Featured Model FTC

Electronic counters in stand-alone version with 12 or 24 channels, which can be equipped with “twin flap” or “twin funnel” systems to increase performance with medium/low counts.

The machines can be equipped with standard bottle conveyor systems or with positive screw conveyor systems.

FTC Series allows to guarantee maximum flexibility with respect to the products/counts required, minimizing costs and format changeover times.

• Great flexibility in the possible configurations and in the management of even very different products/counts • Excellent recovery and containment system for dust emitted during product transfer and transport • Optical sensors (transmitters and receivers) integrated in a dedicated box, equipped with RS485, accelerometer and self-calibration functions

TECHNICAL DATA MECHANICAL SPEED: Bottles-cycles/minute Tablet Ø (mm) Capsules size (A) (G)

FTC 12

FTC 24

Up to 75 5 - 20 000 - 5 from 20 to 100 mm from 55 to 185 mm

Up to 150 5 - 20 000 - 5 from 20 to 110 mm from 55 to 185 mm

“A” Diameter of round bottle. “G” Total bottle height, without closure.

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ORAL SOLID DOSE

Blister INTEGRA SERIES (220) Featured Model INTEGRA 220 with MA-i 150

Complete blister lines designed to provide maximum manufacturing efficiency and higher ergonomic standards in accordance with cGMP norms.

The main mechanics as well as the packaging reels are stored at the back of the machine to facilitate accessibility. As a result, the operators can benefit from a wider working area to carry out tasks safely and easily.

• Suitable to be equipped with containment technologies • Feeding section with or without enclosure • Suitable for manual product feeding • Rapid size change-over operations • Each group managed by servo driven motors • Quick-release system to easily replace of various infeed units • Flat sealing station • Intermittent-motion cartoning section • Stand alone blister section available under request • Suitable for small-batch production • Ready for sustainable materials (PPWR compliance) (*) Nominal production speed.

SPEED RATES* BLISTER SECTION: Forming (cycles/min) Cutting (blisters/min) Cartoning (cartons/min)

INTEGRA 220 Up to 65 Up to 220 Up to 150

Up to 65 Up to 220 Up to 220

SIZE RANGE Blister Width Blister Height Blister Length Forming Depth Carton Width Carton Height Carton Length

SPEED RATES* 30 - 80 mm 3 - 12 mm 70 - 140 mm Up to 12 mm 35 - 90 mm 15 - 90 mm 70 - 150 mm

SPEED RATES* 30 - 86 mm 3 - 12 mm 70 - 140 mm Up to 12 mm 35 - 90 mm 15 - 90 mm 75 - 150 mm

with MA-i 150

INTEGRA 220 with MA 260

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ORAL SOLID DOSE

Blister INTEGRA SERIES (320) Featured Model INTEGRA 320 with MA-i 150

Integrated continuous motion monoblock machine integrating the two operations of blister thermoforming and packaging in cartons. The line is composed of two sections, each managed by a PC, and it is characterized by a small footprint.

The blistering section is managed by servo motors and features two splicing tables with hidden cutter and automatic grip vacuum. A rotating unit picks up the blisters from the die cutter and positive deposits it on the connecting conveyor.

Thanks to a 3 axis translation, the ROBOVISION, a robotized blister feeding system, carries out different kinds of blister stackings on the bucket belt of the cartoning section.

• Industry 4.0 compliant • 1 lane • Flat sealing • Splicing tables • Cartoning section with specially designed belt conveyor for blister • Integrated robot (Robovision) • New system of carton squaring • 2 servo driven independent pushers • Minimum product and materials load control • Cross control product-carton-leaflet • Ready for sustainable materials (PPWR compliance)

(*) Nominal production speed.

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SPEED RATES* BLISTER SECTION: Forming (cycles/min) Cutting (blisters/min) Cartoning (cartons/min)

INTEGRA 320

INTEGRA 320

Up to 75 Up to 320 Up to 260

Up to 75 Up to 320 Up to 260

SIZE RANGE Blister Width Blister Height Blister Length Forming Depth Carton Width Carton Height Carton Length

SPEED RATES* 30 - 82 mm 3 - 9 mm 70 - 140 mm Up to 9 mm 35 - 90 mm 15 - 90 mm 70 - 150 mm

SPEED RATES* 30 - 86 mm 3 - 9 mm 70 - 140 mm Up to 9 mm 30 - 90 mm 15 - 90 mm 75 - 150 mm

with MA-i 150

with MA 260

ORAL SOLID DOSE

Blister INTEGRA SERIES (520) Featured Model INTEGRA 520 with MA 260

The Integra 520 and 520V robotized blister lines combine fast size changeover with an improved footprint. Independent servo-driven motors manage each section of the entire production process.

Both the machines can be equipped with different product feeders, according to manufacturing specifications. Quick-release fasteners provide a tool-free change-over of loading and feeding units.

The new rotating drum* for cartons opening and transfer combined with the “Cinquecento”* product insertion unit represent cutting-edge mechanical innovations. (*) Only on Cartoner MA 500.

• Monoblock machine designed in accordance with cGMP norms • Fast format changeover • Indipendent servo-driven motors • Two splicing tables with hidden cutter and automatic grip vacuum • Preheating and forming station in the rear side of the machine • Horizontal sealing station that follow the motion for pressure uniformity • Cooling plates of the film after the sealing • Robotized blisters feeding system (Robocombi) • Ready for sustainable materials (PPWR compliance) (*) Nominal production speed.

SPEED RATES* BLISTER SECTION: Forming (cycles/min) Cutting (blisters/min) Cartoning (cartons/min)

INTEGRA 520

INTEGRA 520

INTEGRA 520

With MA 260

With MA 360

With MA 500

Up to 65 Up to 520 Up to 260

Up to 65 Up to 520 Up to 360

Up to 65 Up to 520 Up to 500

SIZE RANGE Blister Width Blister Height

SPEED RATES* 30 - 86 mm 3 - 9 mm

Blister Length Forming Depth Carton Width Carton Height Carton Length

70 - 140 mm Up to 9 mm 30 - 90 mm 15 - 90 mm 75 - 150 mm

SPEED RATES* 30 - 86 mm 3 - 9 mm (12 mm opt.)

70 - 140 mm Up to 9 mm 30 - 90 mm 15 - 90 mm 75 - 150 mm

SPEED RATES* 30 - 86 mm 3 - 9 mm (12 mm opt.)

70 - 140 mm Up to 9 mm 30 - 90 mm 15 - 90 mm 75 - 150 mm

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ORAL SOLID DOSE

Blister INTEGRA SERIES (720) Featured Model INTEGRA 720 with MA 500

INTEGRA 720 represents Marchesini Group’s fastest blister packaging solution, engineered to deliver maximum productivity without sacrificing efficiency or reliability. It is a high‑performance, continuous‑motion system that combines advanced engineering with state‑of‑the‑art features.

Its compact footprint allows the machine to fit even into reduced production environments without compromising speed, while offering high flexibility. The machine supports a wide range of thermoforming and lidding materials, including mono‑material solutions, and is designed to ensure long‑term reliability with low maintenance requirements and a reduced Total Cost of Ownership (TCO).

The blisters are transferred to the cartoning section by ROBOCOMBI, which performs stacking operations without any format‑part adjustments, requiring only HMI settings. On the cartoner, the rotating drum delivers the cartons to the “Cinquecento”* insertion mechanism, completing the process with outstanding precision. (*)Available on MA 500.

• Balcony style design • Designed in accordance with cGMP regulations • 1 or 2 or 3 lanes • Each group managed by servo driven motors • Size parameters set on the PC for fast changeover • Compact line • Automatic pitch adjustment • Integrated Robocombi • High-speed continuous motion cartoning unit • Ready for sustainable materials (PPWR compliance)

(*) Nominal production speed.

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SPEED RATES* BLISTER SECTION: Forming (cycles/min) Cutting (blisters/min) Cartoning (cartons/min)

INTEGRA 720

INTEGRA 720

INTEGRA 720

With MA 260

With MA 360

With MA 500

Up to 65 Up to 720 Up to 260

Up to 65 Up to 720 Up to 360

Up to 65 Up to 720 Up to 500

SIZE RANGE Blister Width Blister Height

SPEED R 30 - 86 mm 3 - 9 mm

Blister Length (2 lines) Blister Length (3 lines) Forming Depth Carton Width Carton Height Carton Length

70 - 140 mm 70 - 90 mm Up to 9 mm 30 - 90 mm 15 - 90 mm 75 - 150 mm

SPEED 30 - 86 mm 3 - 9 mm (12 mm opt.)

70 - 140 mm 70 - 90 mm Up to 12 mm 30 - 90 mm 15 - 90 mm 75 - 150 mm

SPEED 30 - 86 mm 3 - 9 mm (12 mm opt.)

70 - 140 mm 70 - 90 mm Up to 12 mm 30 - 90 mm 15 - 90 mm 75 - 155 mm

ORAL SOLID DOSE

Blister NOVA Featured Model NOVA

NOVA represents the new generation of Marchesini blister machine. It is a high‑performance continuous‑motion system that combines innovative engineering with cutting‑edge features

• Compact footprint • Modular design • Easy to use, with a short learning time • Servo-driven, providing accurate, repeatable, and synchronized movements • Flexible, supporting a wide range of forming and lidding materials, including the mono-material solutions • Quick-release fasteners provide a tool-free change-over of loading and feeding units • Reliable over time, with low maintenance requirements and a reduced Total Cost of Ownership (TCO) • Machine can be connect to the Cartoner in both robotic or magazine solution • Ready for sustainable materials (PPWR compliance)

SPEED RATES* BLISTER SECTION: Forming (cycles/min) Cutting (blisters/min) SIZE RANGE Blister Width Blister Height Blister Length

NOVA Up to 65 Up to 600 30 - 90 mm Up to 12 mm 60 - 150 mm

(*) Nominal production speed.

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ORAL SOLID DOSE

Blister MB SERIES Featured Model MB 422

Cutting-Edge “stand alone” Machines.

Marchesini Group is able to offer a wide range of stand alone machines suitable to meet all customer needs, ensuring maximum reliability in terms of performance and production flexibility.

• MB Series machines can be installed very easily in any type of line, thanks to the compactness and easy connection to every exixting downstream cartoning machine

SPEED RATES* BLISTER SECTION: Forming (cycles/min) Cutting (blisters/min) SIZE RANGE Blister Width Blister Height Blister Length Forming Depth (*) Nominal production speed.

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• Suitable for different layout needs • Maximum accessibility and safety • Easy and fast size change over • Ready for sustainable materials (PPWR compliance)

MB 422

MB 432

MB 442

MB 452

Up to 65 Up to 220

Up to 75 Up to 320

Up to 50 Up to 420

Up to 65 Up to 520

30 - 80 mm 3 - 12 mm 70 - 140 mm Up to 12 mm

30 - 86 mm 3 - 9 mm 70 - 140 mm Up to 9 mm

30 - 86 mm 3 - 12 mm 70 - 140 mm Up to 12 mm

30 - 86 mm 3 - 9 mm 70 - 140 mm Up to 9 mm

ORAL SOLID DOSE

Strip Pack MST SERIES (Vertical) Featured Model MST 300

Automatic machines for packaging solid products in strips (tablets and/or dragées, capsules and effervescents etc). These machines are designed to minimize the layout, in order to make the operator oversee the entire production process.

Efficiency and flexibility are provided by the fast format changeover and the balcony structure.

The MST Series are available in standalone version or can be connected to cartoners (in line or 90 degrees).

• cGMP compliants • Drive unit separated from functional modules • Parts in contact with the product made of FDA approved materials • Rollers overheating control STRIP PACKER Nr. of channels Tablets (strokes per channel/min) Strips (strokes per channel/min) Foil width (mm) Reel Ø (mm)

• Different feeders available, according to the product to be machined • Fast format chengeover • Splice tables • Automatic film alignement

MST 200 Up to 12 Up to 300

MST 200 MINI Up to 12 Up to 300

MST 300 Up to 16 Up to 300

MST 300 MINI Up to 16 Up to 300

MST 300 L Up to 22 Up to 300

Up to 90 Up to 220 Up to 400

Up to 120 Up to 220 Up to 400

Up to 90 Up to 340 Up to 400

Up to 120 Up to 340 Up to 400

Up to 90 Up to 450 Up to 400

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ORAL SOLID DOSE

Strip Pack MST SERIES (HORIZONTAL) Featured Model MST 300 H

MST300H is designed to realize four-side sealed foil pack (strip pack) containing flat-shaped solid products, such as bottlepack, blisters, rapid tests and medical devices.

The horizontal feeding unit fills the strip with product, seals and discharges it at the outfeed station.

Balcony-type construction with separate motorization from the functional modules, to ensure ergonomic, mainteinance and safety.

Possibility to process different kind of thermo-sealeble films.

Infeed and outfeed modules can be customized on the type of production and specific customer requirements.

• cGMP compliants • Stand alone or connected versions • Step by step horizontal feeding conveyor • Two reel-holders equipped with reel and control sensors • Splice detection on films • Vertical film cutting unit • Transversal cutting driven by servomotors • Size sealing rollers • Product presence and strip filling controls • Fast format changeover • Splice tables • Rollers overheating control • Automatic film allignement

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STRIP PACKER Nr. of channels Max output (strokes per channel/min) Reel width (mm) Reel Ø (mm)

MST 300 H Up to 5 Up to 60 Up to 340 Up to 400

ORAL SOLID DOSE

Rigid tube MT 1000 Featured Model MT 1000

Tubes filler-capper for tablets.

Automatic machine suitable to count and introduce positively tablets in plastic or metallic rigid tubes, cylindrical-shaped (patented solution). Final tube closure with pressure cap and discharge of the tubes correctly filled on a bucket conveyor at machine outfeed, with cap facing the operator side.

• This machine has been designed to ensure both high efficiency and quality • Balcony type • Steel an aluminium frame with AISI304 stainless steel panels • Patented tube feeding and orienting system • Direct tubes discharging system on transport chain • Two parallel belts conveyors with independent motorization • 4 groups of 12 tubes holding bushes coupled on belts • Sinchro-dynamic mode

TECHNICAL DATA MAX MECHANICAL SPEED: Tablets/min (tubes/min)

MT 1000

TUBE DIMENSIONS* Cap diameter (mm) Tube ext diameter (mm) Tube height (mm)

SPEED RATES* 18 - 44 16 - 40 60 - 160

Up to 1000 Up to 100

(*) Optional

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ORAL SOLID DOSE

Under containment INTEGRA SERIES Featured Model INTEGRA 320 UNDER CONTAINMENT

All process steps are first defined with the customer, in order to guarantee line flexibility and to protect the operative while they are handling products and materials.

• Machine setup • Bulk product feeding • Cleaning procedure • Troubleshooting procedures

• Operatives can work without special protective clothing • No time-consuming entry and exit procedures for people and material

INTEGRA 320

SPEED RATES* BLISTER SECTION: Forming (cycles/min) Cutting (blisters/min) Cartoning (cartons/min)

INTEGRA 220

INTEGRA 220 V

with MA-i 150

with MA 260

with MA-i 150

Up to 65 Up to 220 Up to 150

Up to 65 Up to 220 Up to 220

Up to 75 Up to 320 Up to 150

SIZE RANGE Blister Width Blister Height Blister Length Forming Depth Carton Width Carton Height Carton Length

SPEED RATES* 30 - 80 mm 3 - 12 mm 70 - 140 mm Up to 12 mm 35 - 90 mm 15 - 90 mm 70 - 150 mm

SPEED RATES* 30 - 86 mm 3 - 12 mm 70 - 140 mm Up to 12 mm 35 - 90 mm 15 - 90 mm 75 - 150 mm

SPEED RATES* 30 - 82 mm 3 - 9 mm 70 - 140 mm Up to 9 mm 35 - 90 mm

(*) Nominal production speed.

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• Cross-contamination is reliably ruled out • Significantly reduced effort required for format changeovers and cleaning

15 - 90 mm 70 - 150 mm

ORAL SOLID DOSE

Under containment COUNTING SOLUTION Featured Model COMPACT 12

Counting Filling and Capping machine for solids with Containment System (RABS) fully integrated with machine. A multi-chamber isolator design to house the filling, counting and capping process equipment including all of the associated product separation and filtration equipment to process batches of tablets containing highly active or toxic pharmaceutical ingredients.

• The isolator’s chamber is designed so as to define an active barrier between the process area and the surrounding environment • Full access within the equipments installed in the isolators • Large glazed areas to provide the best possible view of all process operations • Negative pressure between the enclosure and the surrounding environment to ensure all potential contamination is contained within the product handling enclosure

• Oval glove ports positioned in order to facilitate the operator-process interface and reduce operator fatigue • Ergonomic improvement to facilitate format changeovers and cleaning operations, also thanks to an internal trolley specifically designed for loading and unloading pieces in complete safety

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LIQUIDS

Stickpack MT SERIES Featured Model MT 1500

The MT machine is an intermittent motion filler for packaging tubular sachets sealed on 3 sides called “sticks”. In particular the Dosing Unit is indicated for liquid at different viscosity (from watery to hight viscous products including stringy ones).

COMPLETE TURNKEY LINE: The Stickpack machine can be linked to a Cartoning Machine thanks to a special conveyor.

IN-LINE outfeed combination or ORTHOGONAL (90°) outfeed combination are applicable to be adaptable on available space at production hall.

The stacking of sticks in boxes can be in 3 ways: on bulk / ordered / on edge.

• Cleanliness: the machine mechanical parts are clearly separated from the product and film passage • CIP/SIP dosing unit design compliant • Fast release function: all filler machine stations are totally dismountable to speed up the size change-over, cleaning, mainteinance operations

TECHNICAL DATA Number of lanes Max. mechanical speed Reel sizes

Format range

MT 1100 4 - 8 lanes* Up to 70 cycles/minute Width max. 550 mm Diameter max. 600 mm Core diam. 76/152mm Stick pack width: 16 - 60 mm Stick pack length: 60 - 160 mm

MT 1300 4 - 12 lanes* Up to 70 cycles/minute Width max. 750 mm Diameter max. 600 mm Core diam. 76/152 mm Stick pack width: 16 - 60 mm Stick pack length: 60 - 160 mm

MT 1500 4 - 16 lanes* Up to 70 cycles/minute Width max.950 mm Diameter max. 600 mm Core diam. 76/152 mm Stick pack width: 16 - 60 mm Stick pack length: 60 - 160 mm

MT 1800 4 - 20 lanes* Up to 70 cycles/minute Width max. 1250 mm Diameter max. 600 mm Core diam. 76/152 mm Stick pack width: 16 - 60 mm Stick pack length: 60 - 160 mm

(out of standard 190 mm)

(out of standard 190 mm)

(out of standard 190 mm)

(out of standard 190 mm)

*Stick width 25 mm (as example)

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• Dosing unit: for every single project the technical department carries out detailed testing to classify the product specifications, based on that the team choose, designs and builds the most suitable dosing unit • Ready for sustainable materials (PPWR compliance)

LIQUIDS

Sachet MS SERIES Featured Model MS 250

The MS series is a Vertical intermittent motion Sachet machine.

High reliability, easy cleaning and extreme accessibility make the MS series suitable for the pharmaceutical market. The vertical sealing is realized by a mechanical approach of the sealing plates and concluded with the pneumatic expansion action of a membrane mounted on the counter plate. This system allows maximum welding efficiency, guaranteeing homogeneity of sealing pressure for a perfect tightness.

The sachet machines are set up both for standalone production and for in-line production by inserting an elevator conveyor to carry out the sachets transferring, stacking and counting ready for the final box. The system can be further expanded by adding the “statistical” as well as “100%” weighing system directly on the elevator.

Ready for sustainable materials (PPWR compliance) TECHNICAL DATA Number of lanes Max. mechanical speed Reel sizes

Format range

MS 235 4 - 10* Up to 75 cycles/minute Width max. 860 mm Diameter max. 2x500x mm or 1x800 mm Core diam. 76/152 mm Sachet width: 25 mm (min.)

Sachet length: 50 - 160 mm

MS 250 4 - 12* Up to 75 cycles/minute Width max. 1060 mm (min. 400 mm) Diameter max. 2x500x mm or 1x800 mm Core diam. 76/152 mm Sachet width: 25 mm (min.)

Sachet length: 50 - 160 mm

*Width 40 mm (as example)

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LIQUIDS

Sachet AS SERIES Featured Model AS 500

Continuous-motion vertical sachet filling for medium-high production capacities.

The continuous motion and the use of rotary sealing elements permit to reach extremely high production speeds and therefore give an unmatchable total capacity in sachets per minute.

The “AS” series machines are designed to be versatile and flexible, permitting a fast and easy format change of the sachets, whether in Width as in Length.

The balcony structure, the design of the components the high quality material, the consistent high manufactoring process quality allow the machine to comply with GMP rules.

All parts in contact with the product are made of Stainless Steel or other FDA-approved material.

The sachet machines are set up both for standalone production and for in-line production by inserting an AS237 elevator conveyor to carry out the sachets transferring, stacking and counting ready for the final box. The system can be further expanded by adding the “statistical” as well as “100%” weighing system directly on the AS237 elevator.

Ready for sustainable materials (PPWR compliance) SACHET FILLING Number of lanes Maximum mechanical output Reel Width Reel Diameter Format range *Sachet width 50 mm (as example)

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AS 500 AS 600 1 – 16* lanes 1 – 12* lanes Up to 200 cycles/minute Width max. 1000 mm Width max. 1200 mm Diameter max. 600 mm // Core diam. 76/152 mm Sachet width: 30 - 150 mm // Sachet length: 40 - 250 mm

LIQUIDS

Bottles/vials OPTO 150 Featured Model OPTO 150

Ophtalmics filling and capping machine.

• Automatic filling capping machine with walking beam transport • Different capping station are avaibale and up to nr. 2 robots to performs capping operations • Suitable for sterile applications vials and bottles and LAF installation in conformity to newest GMP Ammex 1 release • Working station: 3 or 4 vials handled per time • Dosing unit: Small dosage: 3 or 4 pumps and needles activated High dosage: Fractioned Dosing logic 50% + 50% Nozzles with diving motion • 2 capping stations: 1st station dropper + 2nd station screw cap TECHNICAL DATA Output

OPTO 150 150 Bottles/min (pitch 4) 120 Bottles/min (pitch 3)

PRODUCT RANGE Dosing Range (with volumetric dosage system)

PRODUCT 0,5 - 100 ml

CONTAINER SIZES (A) ø of round bottle (H) Vials height (F) ø Internal mouth minim.

(H) Closure Height

16 - 35 mm 35 - 100 mm 5 - 7 mm 10 - 50 mm

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LIQUIDS

Bottles/vials NETTUNO Featured Model NETTUNO

Automatic double‑pitch machine for filling and capping pharmaceutical and cosmetic bottles, configurable with up to three caps per container. Equipped with 100% in-line weight control, torquecontrolled cap application using brushless motors, and a servo‑driven dip‑tube tightening system for spray pumps. Its compact footprint makes it ideal for installation within UDAF environments, ensuring high precision, cleanliness, and process reliability.

TECHNICAL DATA • Industry 4.0 ready: the machine supports the latest IoT technologies • Designed in accordance with cGMP regulations

Simgle Pitch

Double Pitch

DOSING RANGE

Depending on various available systems

From 0.5 to 300 ml

From 0.5 to 100 ml

VIAL MINIMUM DIAMETER

15 mm

15 mm

VIAL MAXIMUM DIAMETER

90 mm

57 mm

MINIMUM TOTAL BODY HEIGHT Closure excluded

40 mm

40 mm

MAXIMUM TOTAL BODY HEIGHT

210 mm

210 mm

MAXIMUM TOTAL DIPTUBE HEIGHT

147 mm

147 mm

MAXIMUM SPEED

50 ppm

100 ppm

Closure excluded

26

NETTUNO

LIQUIDS

Bottles/vials ML SERIES (Intermittent) Featured Model ML 642

Automatic intermittent motion machines, suitable to fill and close a wide range of liquid containers.

Stainless steel covered frame and clear Separation between the bottle transport and mechanical area. Machine motor with electronic speed variation, settings from zero to maximum.

Through FLEX-LINK tabletop conveyor for bottle infeed and discharge with adjustable guides in stainless steel AISI304. Independent drive with speed adjustment from Display.

Industry 4.0 ready: the machine supports the latest IoT technologies.

TECHNICAL DATA Note Functions Capping towers Product Mechanical speed (pcs/min) Liquid Dosing Range (ml) Container diameter Ø Width x Width square container Long side rectangular container Short side rectangular container Container height

ML 639 Automatic, in line, intermittent Caps Retorquer 2, 3 or 4 screwing heads Bottles 80-120-160 (2, 3, 4 heads) --

ML 640 Automatic, intermittent Motion Plugger & Capper 1,2,3 capping/ screwing towers Bottles 75 cycl./min

ML 642 Automatic, intermittent Motion Filler, Plugger, Capper 1,2,3 capping/ screwing towers Bottles 75 cycl./min

ML 646 Automatic, intermittent Motion Filler, Plugger, Capper 1,2,3 capping/ screwing towers Bottles 75 cycl./min

ML 643 Automatic, intermittent Filler, Capper 1 capping/ screwing towers Bottles 100

-18 - 90 mm 20 - 80 mm

1 - 500 Steel 1 - 300 Ceramic 18 - 90 mm 20 - 80 mm

0,5 - 100

18 - 80 mm 20 - 80 mm

1 - 500 Steel 1 - 300 Ceramic 18 - 90 mm 20 - 80 mm

20 - 100 mm

20 - 85 mm

20 - 85 mm

20 - 85 mm

-

20 - 60 mm

20 - 60 mm

20 - 60 mm

20 - 60 mm

-

40 - 140 mm

35 - 180 mm

35 - 180 mm

35 - 180 mm

35 - 150 mm

18 - 65 mm -

27

LIQUIDS

Bottles/vials ORBITA-L 200 Featured Model ORBITA 200

ORBITA‑L, a modular machine for filling and capping non‑injectable liquid products, featuring two key advancements: a magnetic transport system that enables 100% in‑process weight control (100% IPC) and a servo‑driven dip tube tightening unit that optimises the capping phase.

• Innovative platform to offer a modern and flexible solution • Product transport THAT DO NOT REQUIRE format change • Variable and multiple dosing system available

TECHNICAL DATA DOSING RANGE

ORBITA 150

ORBITA 200

Depending on various available systems

From 5 to 300 ml

From 5 to 150 ml

VIAL MINIMUM DIAMETER

15 mm

15 mm

VIAL MAXIMUM DIAMETER

60 mm

40 mm

MINIMUM TOTAL BODY HEIGHT Closure excluded

40 mm

40 mm

MAXIMUM TOTAL BODY HEIGHT

210 mm

210 mm

MAXIMUM TOTAL DIPTUBE HEIGHT

120 mm

120 mm

MAXIMUM SPEED

150 ppm

200 ppm

Closure excluded

28

LIQUIDS

Bottles/vials ML SERIES (Continuous Motion Rotatory) Featured Model ML 636 1T

Availability of pure capping machines in continuous motions or Monoblock for filling and capping.

The high speed rotary monobloc machine can be equipped with filling pumps and one or two capping turrets according to the kind of product to be handled.

• Different dosing system available • Possibility to equip the machine with CIP/SIP/WIP systems TECHNICAL DATA Note Functions Capping towers Product Mechanical speed (pcs/min) Liquid Dosing Range (ml) Containe diameter Ø Width x Width square container Long side rectangular container Short side rectangular container Container height

ML 667 1T

4 Heads

ML 668 2T Capper 2 (4 + 4 Heads)

• Designed in accordance with cGMP regulations

ML 618 1T ML 618 2T Automatic Continuous rotary

ML 636 1T

ML 636 2T

Filler, Capper 2 (8+8 heads) 1 (16-heads)

1 (8-heads)

2 (16+16 heads)

Bottles 250

300

300

300

500

500

-

30÷300

10÷100

18 - 80 mm

18 - 70 mm

18 - 40 mm

20 - 80 mm

-

-

20 - 100 mm

-

-

20 - 60 mm

-

-

40 - 200 mm

50 -180 mm

40 -100 mm

29

LIQUIDS

Bottles/vials ML SERIES (Continuous Motion Linear) Featured Model ML 662

Monoblock linear filler with continuous rotary closures, available in different configurations.

Design with clear separation between the dosing-capping section and the drive mechanisms which are placed inside the machine basement. The machine filling area is with balcony design and bottles transport is made on the infeed conveyor.

• Variable speed for all the machine belts • Robotized machine functions driven by servo motors • Quick size changeover with minimum adjustments or replacement of parts • Industry 4.0 ready: the machine supports the latest IoT technologies • Designed in accordance with GMP regulations • Possibility to equip the machine with CIP/SIP/WIP system • Different dosing system available

30

TECHNICAL DATA Note Functions Capping towers Product Mechanical speed (pcs/min) Liquid Dosing Range (ml) Container diameter Ø Width x Width square container Long side rectangular container Short side rectangular container Container height

ML 661 1T Linear /continuous rotary Filler, Capper 1 (8-Heads) Bottles 250 0,5 - 500 Steel 0,5 - 300 Ceramic 18 - 70 mm 20 - 70 mm 20 - 70 mm 20 - 60 mm 35 - 180 mm

ML 662 2T Linear /continuous rotary Filler, Capper 2 (16-Heads) Bottles 250 0,5 - 500 Steel 0,5 - 300 Ceramic 18 - 70 mm 20 - 70 mm 20 - 70 mm 20 - 60 mm 35 - 180 mm

CREAMS

Squeezable tubes COLIBRÌ Featured Model COLIBRÌ

Automatic tube filling and closing machine.

Designed for filling and closing metal, plastic, polyfoil or laminate tubes, it is constructed to work in a pharmaceutical environment according to the highest technological standards to garantee the maximum productivity and quality.

• Capsized tube control service • 12-position turntable • 316 L parts in contact with the product with tri-clover connections • Fixed injector with positive shut-off valve and nozzle cleaning by air blow • Safety coupling to protect mechanical parts from overload dosing unit • Special execution enabling to transfer the dosing group, still totally assembled (hopper, filling valve, filling valve housing, piston, cylinder, injector and nozzle), from the dosing area to the washing and sterilization area • Predisposition for LF-Exhaust • Industry 4.0 Software Functions Package for the management of the machine

TECHNICAL DATA Note Functions Mechanical speed (pcs/min) Dosage range (ml) Tube ø (mm)

Total tube length with cap (mm)

COLIBRÌ Automatic Intermittent Rotary Filling, sealing 80 (100) 1 - 390 11 - 40 (Alu) 10 - 50 (PE, Polyfoil® PE, Polyfoil® PP, Recycle PE Tube, PCR, Reduce, Bio-Based Tube, Wood/Carton/Paperbased Tube) 50 - 250

31

CREAMS

Squeezable tubes MILLENIUM SERIES Featured Model MILLENIUM 200

Intermittent motion linear automatic machine for filling and sealing aluminium, polyethylene and laminate tubes. Cantilevered frame design to improve accessibility, maintenance and cleaning operations.

Main frame and base of the machine in AISI 304 stainless steel. Parts in contact with the product in AISI 316L stainless steel. Machine suitable to operate under laminar flow and sterile environments.

Independent servo motors to allow a great versatility in the configuration and make each function independent. Automatic adjustment of the tube height managed at each size changeover.

Bi/Tricolors products dosing unit available.

Prearrangement for any variable data printer (inkjet or laser) and related OCV/OCR cameras control.

Easy installation of sensors and cameras for tube quality controls: correct tube orienting, correct filling, cutting and sealing tubes. Available 100% tubes check weight control with feedback signal to dosing piston to improve a product filling control. Quick size changeover without tools.

TECHNICAL DATA Note Functions Mechanical speed (pcs/min) Dosage range (ml) Tube ø (mm)

Total tube length with cap (mm)

32

MILLENNIUM 120 Automatic Intermittent Linear Filling, sealing 120 1 - 350 11 - 40 (Alu) 10 - 50 (PE, Polyfoil® PE, Polyfoil® PP, Recycle PE Tube, PCR, Reduce, Bio-Based Tube, Wood/Carton/Paper-based Tube) 50 - 250

MILLENNIUM 200 Automatic Intermittent Linear Filling, sealing 200 1 - 350 11 - 40 (Alu) 10 - 50 (PE, Polyfoil® PE, Polyfoil® PP, Recycle PE Tube, PCR, Reduce, Bio-Based Tube, Wood/Carton/Paper-based Tube) 50 - 250

CREAMS

Jar MV 545 Featured Model MV 545

Intermittent motion Monoblock machine suitable for the filling and capping of jars.

Design, manufacturing and ergonomics, in accordance with cGMP norms.

AISI 304 stainless steel frame. Parts in contact with the product in AISI 316L stainless steel.

Pre arrangement of sealing of aluminum foil by pre-cut foil or reel feeding.

Pre arrangement of under cap, plastic lid, by pick & place and vibratory bowl feeder.

Capping unit able to handle both press on cap or screw cap.

Availability of automatic plastic jar and cap feeders/unscramblers.

Pre arrangement for any variable data printer (inkjet or laser) and related OCV/OCR cameras control.

Quick size changeover.

TECHNICAL DATA Note Functions Mechanical speed (pcs/min) Dosage range (ml) Jar Ø (mm) Jar height with cap (mm) Cap Ø (mm) Cap height (mm)

MV 545 Intermittent motion monoblock Filling, capping 75 3-500 35-100 35-80 from 35 to 100 mm (with cap) from 10 to 35 mm

33

POWDERS

Stickpack MT SERIES Featured Model MT 1300

The MT machine is an intermittent motion filler for packaging tubular sachets sealed on 3 sides called “sticks”. In particular the Auger Filler dosing unit is indicated for powder/dusty products (not free flowing).

The MT series filler handles powder, granular, liquid and pasty products as well as single pieces.

LINE COMBINATION: The Stickpack machine can be linked to a Cartoning Machine thanks to a special conveyor.

IN-LINE outfeed combination or ORTHOGONAL (90°) outfeed combination are applicable to be adaptable on available space at production hall.

The stacking of sticks in boxes can be in 3 ways: on bulk / ordered / on edge.

• Cleanliness: the mechanical parts are clearly separated from the product and film passage • Fast release function: all filler machine stations are totally dismountable to speed up the size change-over operations

TECHNICAL DATA Number of lanes Max. mechanical speed Reel sizes

Format range

MT 1100 4 - 8 lanes* Up to 70 cycles/minute Width max. 550 mm Diameter max. 600 mm Core diam. 76/152mm Stick pack width: 16 - 60 mm Stick pack length: 60 - 160 mm

MT 1300 4 - 12 lanes* Up to 70 cycles/minute Width max. 750 mm Diameter max. 600 mm Core diam. 76/152 mm Stick pack width: 16 - 60 mm Stick pack length: 60 - 160 mm

MT 1500 4 - 16 lanes* Up to 70 cycles/minute Width max.950 mm Diameter max. 600 mm Core diam. 76/152 mm Stick pack width: 16 - 60 mm Stick pack length: 60 - 160 mm

MT 1800 4 - 20 lanes* Up to 70 cycles/minute Width max. 1250 mm Diameter max. 600 mm Core diam. 76/152 mm Stick pack width: 16 - 60 mm Stick pack length: 60 - 160 mm

(out of standard 190 mm)

(out of standard 190 mm)

(out of standard 190 mm)

(out of standard 190 mm)

*Stick width 25 mm (as example)

34

• Dosing unit: for every single project the technical department carries out detailed testing to classify the product specifications. Based on that the team choose, designs and builds the most suitable dosing unit • Ready for sustainable materials (PPWR compliance)

POWDERS

Sachet MS SERIES Featured Model MS 235

The MS235 is a Vertical intermittent motion Sachet machine suitable also for powders products.

The auger dosing is ideal for processing powdery products in which a mechanical action is required, performed through the rotation of the augers, to determine the fall of the powder inside the dosing funnels.

Inside the dosing hopper, the product is led from the feed augers to the dosing augers.

While the feed augers are controlled by a single Brushless motor, the dosing augers have an independent motorization for each dosing lane.

This independence determines the possibility of correcting the weight of each dosing channel during the production batch and have the possibility of feedback correction from checkweigher.

Ready for sustainable materials (PPWR compliance) TECHNICAL DATA Number of lanes Max. mechanical speed Reel sizes

Format range

MS 235 4 - 10* Up to 75 cycles/minute Width max. 860 mm Diameter max. 2x500x mm or 1x800 mm Core diam. 76/152 mm Sachet width: 25 mm (min.)

Sachet length: 50 - 160 mm

MS 250 4 - 12* Up to 75 cycles/minute Width max. 1060 mm (min. 400 mm) Diameter max. 2x500x mm or 1x800 mm Core diam. 76/152 mm Sachet width: 25 mm (min.)

Sachet length: 50 - 160 mm

*Width 40 mm (as example)

35

POWDERS

Sachet AS SERIES Featured Model AS 600

Continuous-motion vertical sachet filling for medium-high production capacities.

The continuous motion and the use of rotary sealing elements permit to reach extremely high production speeds and therefore give an unmatchable total capacity in sachets per minute.

The “AS” series machines are designed to be versatile and flexible, permitting a fast and easy format change of the sachets, whether in Width as in Length.

The balcony structure, the design of the components and the use of Stainless Steel allow the machine to comply with GMP rules.

All parts in contact with the product are made of Stainless Steel or other FDA-approved material.

• Continuous motion: (rotary sealing elements) fully controlled by servomotors, allowing to reach high speed of up to 200 cycles/ minute • Reel Width up to 1200 mm, diameter up to 600 mm department carries out detailed testing to classify • Easy changeover design for allowing to change de sachets Width and the number of lanes of the machine • Sachet length is always adjustable anytime from HMI SACHET FILLING Number of lanes Maximum mechanical output Reel Width Reel Diameter Format range * Sachet whith 50 mm (as example)

36

• Fully touchscreen HMI controlled with full 4.0 Software Industry implementations (21CFR11, recipes management, remote troubleshooting, remote data control, etc.)

• AS Series can be connected to any secondary packaging (conveyors for bulk boxing, automatic cartoner, VFFS, flow-pack, etc) • Ready for sustainable materials (PPWR compliance)

AS 500 1 – 10 lanes*

AS 600 1 – 12 lanes*

Up to 200 cycles/minute Width max. 1000 mm Width max. 1200 mm Diameter max. 600 mm // Core diam. 76/152 mm Sachet width: 30 - 150 mm // Sachet length: 40 - 250 mm

The technical specifications given in this catalogue are subject to change without prior notice or liability.

Size range may vary in accordance with the different applications.

The Marchesini Group constantly updates its products to meet market needs.

Edition April 2026

Marchesini Group S.p.A. Via Nazionale 100 • 40065 Pianoro BO ITALY T +39 051 047 9111 sales@marchesini.com marchesini.com

MARCHESINI GROUP INSPIRED BY THE EXTRAORDINARY