GENERAL CATALOGUE
Packaging solutions
inspired by the extraordinary
We at Marchesini Group are proud leaders in manufacturing and integrating complete lines since 1974.
countries worldwide, it relies on a network of agencies and 16 foreign subsidiaries to more percentages in Europe, China, the USA, and Latin America.
The Group is structured into three Business Units: Pharma, Aseptic and Cosmetic. In particular, the Aseptic Business Unit provides complete filling lines for injectable products in ampoules, cartridges, syringes and vials, covering washing, depyrogenation, handling of RTU containers, liquid filling, powder filling, inspection, labeling and end‑of‑line.
In 2025, the Group formed a strategic partnership with AST, a USA company whose aseptic technologies enhance those of Corima, MAR, and CMP Pharma production plants, strengthening its aseptic solutions portfolio.
Keypoint
Customizable solutions to inspect different types of containers and products.
All machines comply with GMP and FDA guidelines.
Balcony-style improves the laminarity of the air flow over the filled containers and facilitates cleaning process.
Fully automated In Process Controls and containment cabinets in Isolation Technology have been implemented, to reduce the risk of microbial contamination and minimize operator interference during the aseptic process.
Flexible solutions for inspection and integrity control of pharmaceutical products.
New models are constantly being developed in our in-house R&D department.
High-speed machines provide solutions aimed at reducing total changeover time and maximising the pharmaceutical process performance.
Wall installation enables maintenance to be carried out from the back-side of the machines in a non-classified technical environment.
Our partnership with AST
Marchesini Group, a leader in pharmaceutical packaging machinery, and AST, a U.S leader in the drug product manufacturing industry, have entered a strategic partnership that combines the expertise, technologies, and global reach of two highly respected industry leaders. The partnership will strengthen their position in sterile fill-finish production by delivering increasingly advanced, integrated and comprehensive solutions. This agreement will provide both companies with greater production capacity and an extended global network for technical assistance and support, while consolidating distribution networks and sales channels across the world.
About AST
AST, LLC has over 60 years of experience designing, manufacturing, and servicing flexible automated processing equipment. In 2006, AST leveraged its experience and close customer relationships to revolutionize the aseptic fill/finish industry with the launch of the ASEPTiCell®.
The ASEPTiCell was the industry’s first aseptic multiformat fill/finish machine capable of processing ready-to-use nested vials, syringes, and cartridges on the same line. Today, AST offers a range of products and services to support drug product development, clinical, and commercial fill/ finish requirements.
AST develops intelligent, intuitive, and innovative solutions that minimize (and where possible eliminate) process and safety risks associated with drug product manufacturing. We will consider all format applications including but not limited to vials, syringes, cartridges, infusion bags, inhalers, bottles, and devices.
Small volume parenteral containers VIALS
VIALS PROCESSING
PRIMARY PACKAGING SECONDARY PACKAGING END OF LINE
INTERNAL WASHING
LABELLING LABELLING
DEPYROGENATION BUNDLING WRAPPING
FILLING/STOPPERING LABELLING
FREEZE DRYING (MACHINE BY THIRD PARTY) LIQUID WASHING
ALU CAPPING CASEPACKING
EXTERNAL DECONTAMINATION LABELLING CODING
VISUAL
The above chart illustrates the complete Marchesini line, whereas the contents of this catalogue detail the primary packaging machines. For information on secondary packaging and end of line machines, visit our website marchesini.com
Small volume parenteral containers AMPOULES
AMPOULES PROCESSING
PRIMARY PACKAGING SECONDARY PACKAGING END OF LINE
INTERNAL WASHING LABELLING BUNDLING WRAPPING
DEPYROGENATION
PLASTIC PACKAGING TRAYS
FILLING/SEALING PAPERBOARD PACKAGING TRAYS
CARTONING LABELLING
CASEPACKING
EXTERNAL DECONTAMINATION
LABELLING
LABELLING
VISUAL INSPECTION PALLETTIZING LABELLING
The above chart illustrates the complete Marchesini line, whereas the contents of this catalogue detail the primary packaging machines. For information on secondary packaging and end of line machines, visit our website marchesini.com
LIQUID FILLING
Small volume parenteral containers DISPOSABLE SYRINGES
SYRINGES PROCESSING
PRIMARY PACKAGING
HANDLING & ASSEMBLING
TUB DEBAGGING DENESTING/ DETRAYING
TUB DELIDDING
VISUAL INSPECTION
FILLING/STOPPERING
LIQUID STOPPERING
SECONDARY PACKAGING END OF LINE
PACKAGING INTO PLASTIC TRAYS
PACKAGING INTO PAPERBOARD TRAYS BUNDLING WRAPPING
TRAYS PACKAGING INTO CARTON LABELLING
LABELLING RENESTING/ RETRAYING CARTONING CASEPACKING
DENESTING/ DETRAYING
LABELLING LABELLING PLUNGERING AND LABELLING PALLETTIZING
BACKSTOP ASSEMBLING SAFETY DEVICE ASSEMBLING LABELLING
The above chart illustrates the complete Marchesini line, whereas the contents of this catalogue detail the primary packaging machines. For information on secondary packaging and end of line machines, visit our website marchesini.com
Internal washing WR SERIES
Rotary continuous motion machines for internal washing and drying of ampoules and vials for Small Volume Parenteral (SVP).
• 8 internal and 3 external washing/blowing stations
• Pre washing in Ultrasonic Bath
OUTPUT
3.000 / 30.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 30 ml
Vials 2R / 500 ml
• Water Recycling
• Automatic drainage and drying
• Container siliconizing
Depyrogenation DEPYR SERIES
Featured Model DEPYR 601
Depyrogenation Tunnels for ampoules and vials for Small Volume Parenteral (SVP).
• Hot chamber with dedicated make up unit and air flow control
• Automatic balancing and air flow adjustment
• Pressure cascade according to process requirements
OUTPUT
3.000 / 24.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 30 ml
Vials 2R / 500 ml
• Outfeed chamber with dedicated cooling coil and 100% air recycling
• Dry Heat sterilization of outfeed chamber
Vial Filling & stoppering STERY SERIES
Featured Model STERY 500
Filling and stoppering machines for liquid or lyo products, suitable for filling vials for Small Volume Parenteral (SVP) in an aseptic process with complete or partial closure using rubber stoppers.
• Intermittent or continuous motion
• Balcony or traditional table top arrangement
• Statistical or 100% weight check
In Process Control (IPC)
• Dosing system: rotary piston and/or peristaltic pumps
OUTPUT
3.000 / 30.000 pcs / h
PRODUCT RANGE
2R / 500 ml
• Inert gas flushing
• Easy integration with RABS or Isolator
• Cleaning and Sterilization in Place (CIP/SIP)
Vial Filling & sealing
M53-L SERIES
Vial filling and stoppering machines for liquid or lyo products, suitable for aseptic process with complete or partial closure using rubber stoppers and alu cap.
• Intermittent motion
• Traditional table top arrangement
• 100% weight check In Process Control (IPC)
• Dosing system: rotary piston and/or peristaltic pumps
OUTPUT
3.000 / 12.000 pcs / h
PRODUCT RANGE
Vials 2R / 500 ml
• Inert gas flushing
• Separate Alu capping unit or integrated on board (monoblock version)
• Easy integration with RABS or Isolator
• Cleaning and Sterilization in Place (CIP/SIP)
Featured Model M53
Vial Filling & stoppering
Small scale production, Lab batch, R&D applications for Glass and Plastic Vials, filled and capped in sterile environment by “Rubber stopper + Alu cap” or “Droppers + Screw cap” in case of ophthalmic products.
• Intermittent motion
• Traditional table top arrangement
• Star wheel transport system
• Dosing system: rotary piston and/or peristaltic pumps
OUTPUT up to 1.500 pcs / h
PRODUCT RANGE 2R / 100R tube vials
• Inert gas flushing
• Easy integration with UDAF and oRABS
Vial Filling & sealing FCM 1C
Small scale production, Lab batch, R&D applications for Glass and Plastic Vials, filled and capped in sterile environment by “Rubber stopper + Alu cap” and “Droppers + Screw cap” in case of ophthalmic products.
• Intermittent motion
• Traditional table top arrangement
• Rotary chain transport system
• Dosing system: rotary piston and/or peristaltic pumps
pcs / h
PRODUCT RANGE up to body diam. 35mm
• Inert gas flushing
• Easy integration with UDAF and oRABS
Powder filling M53-P SERIES
Vial filling and stoppering machines for sterile or non sterile powder, with complete closure using rubber stoppers and alu cap.
• Intermittent motion
• Traditional table top arrangement
• 100% weight check In Process Control (IPC)
• Easy integration with RABS or Isolator Featured Model M53-P
• Dosing system: by vacuum pressure disks or augers
3.000 / 7.200 pcs / h
g / 10 g
• Separate Alu capping unit or integrated on board (monoblock version)
Cartridge filling and sealing
M55-K SERIES
Cartridge stoppering, filling and sealing machines for liquid products, suitable for aseptic process.
• Intermittent motion
• Traditional table top arrangement
• Fractional, Bubble free filling system
• Dosing system: rotary piston and/or peristaltic pumps
OUTPUT
M55-K4 up to 200/min
M55-K6 up to 300/min
• Inert gas flushing
• Combi version M55 KV for processing cartridges and vials
• Easy integration with RABS or Isolator
• Cleaning and Sterilization in Place (CIP/SIP)
M55-KV up to 100 (Vials) up to 200 (Cartridge)
PRODUCT RANGE
M55-K4 Cartridge 1.5 ml - 20 ml
M55-K6 Cartridge 1.5 ml - 5 ml
M55-KV Cartridge 1.5 ml - 20 ml Vial 2R - 30R
Featured Model M55-K
Ampoules Filling & sealing
RS-F SERIES
Filling and sealing machines for liquid products, suitable for filling open or closed ampoules in an aseptic process.
• Intermittent motion
• Dosing system: rotary piston and/or peristaltic pumps
• Easy integration with RABS
• In Process Control (IPC)
OUTPUT
6.000 / 24.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 30 ml
Vials 2R / 30R
• Inert gas flushing
• Sealing gas flow controlled by mass flow meters
• Vials processing capability
• Cleaning and Sterilization in Place (CIP/SIP)
Featured Model RS-F 24
Tub debagging and delidding FREETUB SERIES
Manual or Automatic machines for single or double debagging, lid and liner removal from Tubs or Trays.
OUTPUT
Up to 6 TUB per minute
Filling & stoppering for Syringes/RTU Containers
EXTRAFILL SERIES
Automatic machine for filling and stoppering of nested Syringes (glass/plastic) and RTU Vials supplied in Tub/Nest or Nested Trays.
• Vacuum filling and stoppering possibility of Vacuum Stoppering
• Statistical or 100% weight check In Process Control (IPC)
• Dosing system: rotary piston and/or peristaltic pumps
OUTPUT
Up to 36.000 syringes / hr
PRODUCT RANGE
Syringes 0,5 ml / 10 ml
Vials 2R / 15R
• Inert gas flushing during filling and/or stoppering
• Easy integration with RABS or Isolator
• Cleaning and Sterilization in Place (CIP/SIP)
Filling & stoppering for Syringes/RTU Containers
Automatic machines for filling and stoppering of Nested Syringes (glass/plastic), RTU Cartridges and RTU Vials in Tub/Nest.
• Vacuum filling and stoppering suitable for high viscosity products
• Statistical weight check In Process Control (IPC)
• Dosing system: rotary piston and/or peristaltic pumps
OUTPUT
• Inert gas flushing during filling and/or stoppering
• Easy integration with RABS or Isolator
• Cleaning and Sterilization in Place (CIP/SIP)
5.000 / 12.000 syringes / hr
PRODUCT RANGE
Syringes 0,5 ml / 50 ml
Vials 2R / 50R
Cartridges 1 ml / 20 ml
Syringes filling and stoppering
Small scale production, Lab batch, R&D applications for Syringes filled and capped in sterile environme.
• Out of nest processing
• Ancillary equipment for manual debagging, deliding, denesting
• Intermittent motion
• Traditional table top arrangement
• Star wheel transport system
OUTPUT up to 1.500 pcs/h
PRODUCT RANGE
Syringes: 0,5 ml / 50 ml plastic/ glass
• Dosing system: rotary piston and/or peristaltic pumps
• Inert gas flushing
• Easy integration with UDAF and oRABS
Alu capping CAPSY SERIES
Alu Cap sealing machines for liquid or lyo products, suitable for closing vials for Small Volume Parenteral (SVP) in an aseptic process.
• Intermittent or continuous motion
• Balcony or traditional table top arrangement
• Automatic Sealing Pressure Regulation
OUTPUT
3.000 / 30.000 pcs / h
PRODUCT RANGE
Vials 2R / 500 ml
• Low particle generation
• Easy integration with RABS or Isolator
Featured Model CAPSY BC
CONTAINMENT BY RABS OR ISOLATOR
Containment ISOL-AIR SERIES
Featured containment type Closed RABS
Containment cabinets suitable for product and/or operator protection within aseptic processes.
• Closed RABS or Isolation technology
• Bio decontamination with Vaporized Hydrogen Peroxide (VHP)
• All types of aseptic transfer connections available
• Environmental Monitoring (EM) devices
• Bag IN / Bag OUT filters
• Washing in Place (WIP)
• HVAC Air Handling Units (AHU)
Benchtop fill-finish systems
GENiSYS® LAB
Containers
Closing/ sealing
Available options
• Vials
• Syringes
• Cartridges
• Vial stopper placement
• Press fit cap application
• Peristaltic or rotary piston pump filling
• In process fill weight verification (IPC)
• Inert gas overlay
• Electronic Batch Records (EBR)
• Single use fuid path
• Syringes
• Cartridges
• Vacuum
• Vent tube
• Combination vent tube/ vacuum
• Inert gas overlay
• Electronic Batch Records (EBR)
• 2 up processing
Dimensions (LxWxH) Up to 840 mm x 500 mm x 800 mm
OUTPUT
• Vials
• Syringes
• Cartridges
• All options listed for CFS and CCS
• Vials
• Cartridges
• Spinning disc
• All options listed for CFS and CCS
• Filling and clousing of 2 containers at a time
Manual placement of 1-2 containers at a time
PRODUCT RANGE
Syringes Vials Cartridges
• Applied force monitoring
• Electronic Batch Records (EBR)
• Screw cap application
GENiSYS® Lab is a full line of bench top fill, close, and sealing equipment, designed for laboratory settings and cGMP processing of small batches. Each system automates the critical aspects of aseptic operation to lower overall risk and ensure the highest standards of product quality and data integrity from the very start of drug development.
Featured Model GENiSYS® LAB
CFS CCS FCP VSS
Featured Model FCP
Featured Model CCS
Featured Model VSS
Cart-Based Fill-Close Module
GENiSYS® C
Model GENiSYS® C
Containers
Vial closing/ sealing
Syringe/cartridge closing
Available options
Dimensions (LxWxH)
• All commercially available RTU nested vials, syringes, and cartridges
• Custom formats available
• Serum or lyo stoppers
• Press fit cap application
• Crimp capping available
• Vacuum
• Vent tube
• Combination vent tube/vacuum
• In process fill weight verfication (IPC)
• Viable, non viable and total particulate monitorning (EM)
• Electronic Batch Records (EBR)
• Pre and post fill container gas purge
• Integrated barrier systems and laminar airflow (LAF) hoods
1800 mm x 625 mm x 1725mm
OUTPUT Up to 20 upm
PRODUCT RANGE
Syringes Vials Cartridges
GENiSYS® C is a fully featured fill and close platform with a small, cart based operational footprint. With the same technology found on AST’s advanced, larger lines, the GENiSYS® C has the full power of our innovative solutions for the full scope of drug development, from discovery to commercial distribution.
Featured
Isolated Small-Batch Filling System
ISOLATED GENiSYS® C
Featured Model ISOLATED GENiSYS® C
Containers
Vial closing/ sealing
Syringe/cartridge closing
Available options
Available machine modules
• All commercially available RTU nested vials, syringes and cartridges
• Trayed and custom formats available
• Serum or lyo stoppers
• Press fit cap or crimp cap application
• Vacuum
• Vent tube
• Combination vent tube/vacuum
• In process fill weight verification (IPC) up to 100%
• Viable, non viable and total particulate monitorning (EM)
• Electronic Batch Records (EBR)
• Pre and post fill container gas purge
• Semi automatic bag opener (SABO)
• Automatic bag opener (ABO)
• Manual tub opener (MTO)
• Automatic tub opener (ATO)
• Vial sealing module (VSM)
Dimensions (LxWxH) Dependent on final confguration
OUTPUT Up to 20 upm
PRODUCT RANGE
Syringes Vials Cartridges
The Isolated GENiSYS® C brings the benefits of AST’s cart based equipment into a fully integrated fill finish system. This compact and flexible line utilizes minimal change parts, recipe driven production processes, and an intuitive human machine interface that unifies fill finish machine, isolator and decontamination system under a single platform.
Fully Robotic Fill-Finish System
GENiSYS® R
Model GENiSYS® R
Containers
Vial closing/ sealing
Syringe/cartridge closing
Available options
Available machine modukes
• All commercially available RTU nested and trayed vials, syringes and cartridges
• Custom formats available
• Serum or lyo stoppers
• Press fit cap application
• Crimp capping
• Vacuum
• Vent tube
• Combination vent tube/vacuum
• In process fill weight verification (IPC) up to 100%
• Viable, non viable and total particulate monitorning (EM)
• Electronic Batch Records (EBR)
• Pre and post fill container gas purge
• Semi automatic bag opener (SABO)
• Automatic bag opener (ABO)
• Manual tub opener (MTO)
• Automatic tub opener (ATO)
• Lyophilization integration
• Vial sealing module (VSM)
• Manual tray loader
Dimensions (LxWxH) Dependent on final configuration
OUTPUT
Up to 20 upm
PRODUCT RANGE
Syringes
Vials Cartridges
The GENiSYS® R is a flexible, multi format system with a full range of automated capabilities and modular configurations to ensure both clinical and commercial products are processed in strict accordance with cGMP standards. AST’s GENiSYS® R prioritizes product stewardship and integrity using robotic handling and advanced quality control measures, including a comprehensive suite of visual and sensor feedback checks.
Featured
Fully Automated Fill-Finish System
ASEPTiCELL®
Containers
Vial closing/ sealing
Syringe/cartridge closing
Available options
Available machine modules
• All commercially available RTU nested vials, syringes and cartridges
• Custom formats available
• Serum or lyo stoppers
• Press fit cap application
• Crimp capping
• Vacuum
• Vent tube
• Combination vent tube/vacuum
• In process fill weight verification (IPC) up to 100%
• Viable, non viable and total particulate monitoring (EM)
• Electronic Batch Records (EBR)
• Pre and post fill container gas purge
• Automatic bag opener (ABO)
• Automatic tub opener (ATO)
• Lyophilization integration
• Vial sealing module (VSM)
• Automatic tray loader
Dimensions Dependent on final configuration
OUTPUT Up to 100 upm
PRODUCT RANGE
Syringes
Vials
Cartridges
The ASEPTiCell® is where the full power of AST’s automated and robotic solutions meet precision modular engineering for the commercial production of liquid pharmaceuticals. Fully automated from start to finish, this highly intuitive, flexible fill finish system processes ready to use nested vials, cartridges and syringes on the same line. ASEPTiCelll® offers industry leading multi modal flexibility, efficiency and precision, with fewer change parts for minimal format changeover time and optimal machine uptime.
Inspection SV SERIES
SV Series are semi automatic machines for the inspection of liquid, lyophilized or powder products in ampoules, vials and cartridges or pre filled syringes.
The machines are equipped with brushless motors for fast rotation (before inspection) and slow rotation (during inspection) to guarantee a complete and efficient control of the product.
OUTPUT
Up to 6.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 25 ml
Vials 2R / 500 ml
Cartridges 1 ml /3 ml
Syringes 0,5 ml / 20 ml
Inspection SA SERIES
Featured Model SA12J
The SA series automatic machines have been designed to meet the needs of those customers looking for a compact solution for the inspection of their products. They can be configured and customized following the production needs of customers.
OUTPUT
Up to 12.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 25 ml
Vials 2R / 100 ml
Cartridges 1 ml /3 ml
Syringes 0,5 ml / 5 ml
Inspection RS SERIES
RS Series are Automatic inspection and leak test machine designed to combine CMP’s know how and experience in camera visual inspection with HVLD (High Voltage Leak Detection) system.
The machines are equipped with 3 or 4 leak test stations and a rotation system in order to improve the quality of the control (360° total surface inspection).
The productivity, the compact design and the performance level have set these models as leading units in our production range.
RS Series can handle ampoules, vials and cartridges.
OUTPUT
Up to 24.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 25 ml
Vials 2R / 100 ml
Cartridges 1 ml /3 ml
Inspection & leak test
RS-LAB SERIES
RS LAB Series were designed to combine CMP’s know how and experience in camera visual inspection with HVLD (High Voltage Leak Detection) system.
Furthermore these models are equipped with an integrated labelling unit for the products which passed all the previous inspections.
The machines are equipped with 4 leak test stations and a rotation system in order to improve the quality of the control (360° total surface inspection).
RS LAB Series can handle ampoules, vials and cartridges.
OUTPUT
Up to 24.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 25 ml
Vials 2R / 100 ml
Cartridges 1 ml /3 ml
Inspection N SERIES
These machines are designed to meet the needs of those customers looking for excellent inspection quality combined with high production speeds. The N series machines can also be equipped with a container integrity control system.
OUTPUT
Up to 36.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 25 ml
Vials 2R / 100 ml
Cartridges 1 ml /3 ml
Syringes 0,5 ml / 10 ml
Leak test LT SERIES
LT Series are our core leak test machines: the rational and compact design makes these units suitable to be inserted in any production context. The system is based on High Voltage Leak Detection technology. It uses a high voltage electrical field and impedance measurement to make each container (ampoules and Vials) to be checked by No. 4 inspection units with customized electrodes. The rotation system before and during inspection guarantee high quality performances. The LT S version is a further step in the integrity control, and it is suitable for products packaged in single dose plastic strips.
OUTPUT
Up to 24.000 pcs / h
PRODUCT RANGE
Ampoules 1 ml / 25 ml
Vials 2R / 30R
Cartridges 1 ml /3 ml
Plastic Strip: max. h 110 mm / max. l 150 mm
Inspection NSY SERIES
No contact “monobloc” machine for the high speed automatic inspection of syringes, with integrated denesting and renesting unit.
The monobloc consists of a unit which performs robotised picking of the syringes from tubs/nests and feeds them into the inspection phase in a single row with no contact between syringes or with metal parts.
This part of the machine is able to contain up to 10 inspection stations to inspect every zone of the syringe: flange, stopper, particle detection, filling level, needle shield, defects in the glass walls and integrity inspection using HVLD (High Voltage Leak Detection) technology.
The monobloc features 5 reject lanes which can be customised to differentiate the rejected syringes and is designed to deliver approved syringes in a single row, without any contact between them or with metal parts. It can be equipped with a variety of optional accessories, including a camera to inspect for nest completeness and the relative syringe count, coding of the nest or tub by labelling, inkjet or laser printing.
OUTPUT
Up to 36.000 pcs / h
PRODUCT RANGE
Syringes 0,5 ml / 10 ml
The technical specifications given in this catalogue are subject to change without prior notice or liability.
Size range may vary in accordance with the different applications.
The Marchesini Group constantly updates its products to meet market needs.
