Arenus Animal Health Canada

ARENUS ARENUS ANIMAL ANIMAL HEALTH HEALTH SOLUTIONS SOLUTIONS NOT NOT JUST JUST SUPPLEMENTS SUPPLEMENTS

SNM AND SUPPLEMENTS SNM AND SUPPLEMENTS

THE THE ARENUS ARENUS STORY STORY At Arenus, we believe in solutions not just supplements. The At Arenus, we resolve believe in not just supplements.

The best solutions thesolutions issue and prevent future problems. best solutions resolve the issue and prevent future problems.

This is why I founded Arenus Animal Health. To offer long term This is why Arenus Animal Health. To offer longface. term solutions forI founded the everyday health challenges that horses solutions for the everyday health challenges that horses face.

As a practicing veterinarian, I’ve spent many sleepless nights As a practicing veterinarian, I’vedecided spent many tending to colicking horses and theresleepless must be nights a better tending to colicking andcolic decided there beAfter a better way to support thesehorses recurrent cases longmust term. way support and these recurrent colic cases long term.

After muchtoresearch careful attention to formulas, the Assure much research and careful attention formulas, the aAssure product family was introduced.

Sincetothat time over decade product family wasacross introduced.

SinceStates that time a decade ago, veterinarians the United haveover come to trust ago, veterinarians across the their United States have come to trust the Assure products to solve toughest digestive cases. the Assure products to solve their toughest digestive cases.

Most supplement companies are created without research or Most supplement created without research. research or simply built on thecompanies grounds ofare others’ ingredient simply on Health the grounds ingredient research.

Arenus built Animal offers of anothers’ exclusive line of unique Arenus Animal Healthresearched offers an exclusive line ofproven uniquein their products, extensively and clinically products, researched and in their final form extensively to offer lasting solutions to clinically common proven health concerns. final form to offer lasting solutions to common health concerns.

Every product, as with every effort of Arenus Animal Health, Every as with everyof effort of Arenus Animal Health, servesproduct, the singular purpose supporting better, more serves thehealth singular ofthrough supporting better, more complete andpurpose wellness nutritional science. Our complete health and wellness science.

Our philosophy is grounded in the through thought nutritional that more is not always philosophy is grounded the thought more is not always better. If you’re feeding ainlarge cocktail that of daily supplements better. you’rethen feeding a large is cocktail daily supplements to yourIfhorse, something wrongofwith the program to horse, then something wronghorses, with the program or your the supplements themselves.isMany particularly or the supplements horses, particularly performance horses,themselves. will benefit Many from supplementation. performance from supplementation.

However, youhorses, need towill be benefit critical about the supplements you’re However, you need to be critical about the supplements you’re giving your horse. giving your horse.

At Arenus best solut

At Arenus, we don’t bring on new supplements to fill a catalog At Arenus, don’t bring supplementsistolimited fill a catalog or sell morewe products.

Ouron linenew of supplements or sell more Our line of supplements to those thatproducts. provide optimum health and serveisalimited purpose to solving those that provide Our optimum health and serve a purpose in a problem. products contain the highest in solving a problem.

Ourthe products contain the highest formulation technology, best ingredients, and proven formulation technology, the reason, best ingredients, andsimple, proven researched results.

For that you will find researched results.

For that reason, you will find simple, straightforward ingredients and a product lineup designed to straightforward ingredients and a product lineup long-term designed to work with your overall care program to promote work overall care program to promote long-term healthwith andyour wellness. health and wellness.

We guarantee that our products will help with the major We guarantee that productsto will help with the major challenges they areour formulated address.

Whether it’s for challenges they are formulated to address.

Whether it’s for digestive, reproductive, respiratory, structural, or overall health, digestive, reproductive, respiratory, structural, orIfoverall health, our products simply work.

Try them for yourself. your horse our Trysatisfied them forfor yourself.

If your horse isn’tproducts healthiersimply or youwork. are not any reason, just give isn’t healthier orWe you arenot notonly satisfied for any reason, just give our team a call. will be happy to personally help our call.aWe willsolution not onlyfor beyour happy to personally help you team figureaout better horse, but we will also you out a better solution for your but we will also take figure the product back and give you a fullhorse, refund. take the product back and give you a full refund.

At Arenus we’ve dedicated ourselves to developing products At Arenus we’ve dedicated ourselves to developing products that actually prevent and resolve the most challenging health that actually prevent and resolve the most health issues that horses face.

We look forward tochallenging working with you to issues that horses face.wellness We look forward to working with you to enhance your animal’s and longevity. enhance your animal’s wellness and longevity.

Sincerely, Sincerely, Jay Altman, DVM Jay Altman, DVM Animal Health President, Arenus President, Arenus Animal Health

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866-791-3344 · ARENUS.CA 866-791-3344 · ARENUS.CA

Arenus nutraceuticals are available through participating veterinarians and veterinary clinics or direct through Arenus. Should your veterinary clinic not Arenus nutraceuticals available participating veterinarians and veterinary clinics or direct through Arenus.location Should for your veterinary clinic not stock the products,are please let usthrough know and we will work with them to see if they are eligible to become a stocking Arenus solutions. stock the products, please let us know and we will work with them to see if they are eligible to become a stocking location for Arenus solutions.

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DIGESTIVE HEALTH THE DIGESTIVE HEALTH CHALLENGES OF TODAY’S EQUINE ATHLETES

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SECURE OR ASSURE - WHY THE DIFFERENT NAMES In working to bring the Assure line of products to Canada, it was discovered that the Assure name had been registered to another company. So, Canada gets the whole Assure line of digestive aids but under the new name Secure. The Secure products will bring the same great results with the same great guarantees as Assure.

= ASSURE

SECURE

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STRESS AND DIGESTIVE ISSUES Colic remains the number one killer for horses. Modern veterinary medicine has reduced and nearly eliminated colic caused by parasite infestations. Advancements in diagnostics, treatment and surgical methods have greatly improved the lives of horses suffering from colic episodes. However, with all these advancements, little has been done to address the management of stress that today’s horses suffer. Stress comes in many forms for our horses. Feed schedules, show schedules, training and exercise, separation from friends and everyday life in stalls and confinement all contribute to stress. For many horses this leads to varying degrees of digestive disturbance, leaky gut or even inflammatory bowel disease or colitis. These conditions are at epidemic levels among horses today. The worst part is that many riders are unaware their horses are even suffering. Digestive disturbance symptoms are too often dismissed because they’ve sadly become the norm. Bad attitudes, cinchy horses, difficult training and frequent bad performance days are all indicators of poor digestive health. Even overt symptoms like poor body condition and diarrhea get overlooked. It’s time that we started looking out for our horses and offered them the relief they deserve.

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THE SECURE SYSTEM SOLUTION The Secure System has become a staple for veterinarians across the country in the fight against tough digestive and gastric issues.

The stressful challenges that horses face has made it necessary to not only resolve digestive health problems, but to prevent issues and maintain long term health. Today more than ever our horses need digestive maintenance and support throughout their lives. They need the help of a great digestive support program. The Secure System addresses these modern day challenges for optimal health, comfort and enhanced performance.

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SECURE PRODUCTS - A DIFFERENT APPROACH The Assure/Secure products were developed with a different approach than other digestive supplements. The goal was to provide the best support to all portions of the digestive tract by adjusting the physiologic disturbances that are the root cause. There is no pharmaceutical product that can achieve this goal, nor a single supplement ingredient that comes close. By combining all of the right ingredients in just the right amount and then utilizing our proprietary Gastrointestinal Stabilizing Technology (GST) to produce an enteric coated delivery system we are able to effectively reverse the causes of GI disturbance. Reducing acidity, improving enzyme digestive function, stabilizing the hind-gut microflora, reducing inflammation and accelerating colonocyte repair and regeneration are all part of the functions of each and every Secure product. Not only have the products been extensively researched, but they have been awarded patents for reducing recurrent colic, reducing ulcers, resolving diarrhea and improving GI motility. Secure provides the most complete and effective method to resolve digestive disturbance and provide a digestive maintenance program that will keep your horses healthy and “happy”.

Bu sa de se co di

“I am amazed at the difference that I have seen in my horses on Assure Guard Gold, they are feeling better and performing better. I recommend Assure Guard Gold to anyone and everyone, even if their horses do not have diagnosed ulcer issues the GI improvements make a remarkable difference.

GI health is so important to the overall health of the horse that the long-term benefits are tremendous!”

Laura Chapot Professional Grand Prix Show Jumper, Arenus Ambassador

DIGES

DIGESTIVE DIGESTIVEHEALTH HEALTH

STRE

STRESS: STRESS:A ADIFFERENT DIFFERENTVIEW VIEW

Our horses l position in t meals, and a struggle to a from friends

OurOur horses horses lead lead stressful stressful lives. lives.

Their Their genetics genetics dictate dictate they they livelive free, free, roam roam large large areas, areas, graze graze 20 20 hours hours a day, a day, andand have have established established position position in the in the “pecking “pecking order” order” of their of their herd. herd.

In captivity, In captivity, ourour horses horses livelive in ainconfinement a confinement management management system, system, areare fedfed intermittent intermittent meals, meals, andand areare often often separated separated from from other other horses. horses.

Although Although there there have have been been many many advancements advancements in horse in horse care, care, it has it has been been a constant a constant struggle struggle to address to address andand manage manage thethe stress stress today’s today’s horses horses suffer. suffer.

Feed Feed schedules, schedules, show show schedules, schedules, training training andand exercise, exercise, separation separation from from friends friends andand everyday everyday lifelife in stalls in stalls andand confinement confinement all all contribute contribute to stress. to stress.

Several stud on digestive the main sys loss and poo consequentl temperature

Several Several studies studies have have been been conducted conducted on on thethe effect effect of stress of stress on on thethe horse. horse.

However, However, very very fewfew have have focused focused on on thethe influence influence of stress of stress on on digestive digestive health. health.

They They often often focus focus on on heartrate, heartrate, cortisol cortisol levels, levels, or reproduction, or reproduction, which which although although important, important, failfail to address to address oneone of of thethe main main systems systems most most influenced influenced by by stress, stress, digestion. digestion.

Many Many times, times, wewe recognize recognize thisthis stress stress as acute as acute or chronic or chronic diarrhea, diarrhea, weight weight loss loss andand poor poor condition, condition, or behavior or behavior changes. changes.

Horses Horses with with these these conditions conditions areare living living in ainstate a state of constant of constant digestive digestive disturbance disturbance andand consequently consequently predisposed predisposed to suffer to suffer from from acute acute or recurrent or recurrent colic colic episodes. episodes.

Even Even a small a small amount amount of additional of additional stress stress such such as a aschange a change in in temperature temperature or aorlow a low water water trough trough cancan tip tip these these individuals individuals intointo a state a state of digestive of digestive distress. distress.

You may be One key com the hindgut of the 3-met area. Work h Although th

YouYou may may be be asking, asking, if these if these issues issues areare so so prevalent, prevalent, why why haven’t haven’t more more studies studies been been performed performed to better to better understand understand thisthis relationship? relationship?

One One keykey component component is access is access to the to the affected affected area. area.

As As many many of us of us have have experienced experienced firsthand, firsthand, it isitextremely is extremely difficult difficult to image to image or enter or enter thethe hindgut hindgut duedue to the to the horse’s horse’s anatomy, anatomy, whether whether in cases in cases of emergency of emergency or as or a asdiagnostic a diagnostic tool. tool.

Consequently, Consequently, with with thethe development development of the of the 3-meter 3-meter endoscope, endoscope, most most of the of the studies studies involving involving digestive digestive health health have have centered centered around around gastric gastric ulcers, ulcers, a more a more easily easily accessible accessible area. area.

Work Work hashas been been done done observing observing thethe influence influence of psychological of psychological stress stress such such as training as training andand showing showing on on gastric gastric ulcer ulcer formation. formation.

Although Although thethe stomach stomach is quite is quite important important it isitstill is still only only a small a small portion portion of the of the total total digestive digestive system. system.

Unlike the h Emission Tom behind man the symptom to classify al Functional G

Unlike Unlike thethe horse, horse, thethe human human digestive digestive tract tract is more is more easily easily accessible, accessible, allowing allowing forfor thethe useuse of many of many new new technologies, technologies, including including Positron Positron Emission Emission Tomography Tomography (PET) (PET) andand Functional Functional Magnetic Magnetic Resonance Resonance Imaging Imaging (FMRI), (FMRI), helping helping physicians physicians to better to better understand understand thethe causes causes behind behind many many gastrointestinal gastrointestinal (GI)(GI) diseases. diseases.

These These technologies technologies have have ledled many many physicians physicians to atoshift a shift in approach, in approach, from from merely merely managing managing thethe symptoms symptoms to treating to treating thethe root root cause cause of the of the disease disease andand its its predisposing predisposing influences. influences.

New New technologies technologies have have made made it possible it possible to classify to classify all all thethe GI diseases GI diseases in humans in humans by by location location andand better better understand understand thethe underlying underlying causes causes of disease, of disease, leading leading to atonew a new term term Functional Functional Gastrointestinal Gastrointestinal Disorders Disorders (FGID.) (FGID.)

Even though understand motility and often the cau may start ou diarrhea, co

Even Even though though these these new new technologies technologies areare notnot available available to the to the horse, horse, wewe cancan stillstill useuse thethe components components of FGID of FGID in humans in humans to better to better understand understand equine equine digestive digestive disorders. disorders.

There There areare many many similarities similarities between between FGID FGID in humans in humans andand horses. horses.

Both Both involve involve abnormal abnormal motility motility andand inflammation. inflammation.

There There is also is also a connection a connection between between thethe nervous nervous andand digestive digestive systems, systems, creating creating a negative a negative feedback feedback loop, loop, disturbances such such as hindgut as hindgut inflammation inflammation andand possibly possibly even even colonic colonic ulcers. ulcers.

In the In the horse horse these these FGIDs FGIDs often often thethe cause cause of digestive of digestive disturbances may may start start outout small small with with weight weight loss loss or poor or poor performance, performance, butbut if left if left untreated untreated can, can, over over time, time, develop develop intointo ulcers, ulcers, chronic chronic andand acute acute diarrhea, diarrhea, colitis, colitis, or even or even colic. colic.

But how doe sand irritatio death of ben secretions, a confinemen disorder.

ButBut how how does does thisthis process process start? start?

There There areare many many different different factors factors thatthat cancan lead lead to hindgut to hindgut disfunction disfunction including including intermittent intermittent meals, meals, sand sand irritation, irritation, antibiotics, antibiotics, NSAIDs, NSAIDs, andand large large grain grain meals. meals.

These These elements elements cancan lead lead to atobuildup a buildup of lactic of lactic acid, acid, altered altered motility motility andand thethe death death of beneficial of beneficial hindgut hindgut microflora. microflora.

Together, Together, these these negative negative effects effects merge merge leading leading to bacterial to bacterial overgrowth, overgrowth, a change a change in mucosal in mucosal secretions, secretions, andand mucosal mucosal inflammation inflammation resulting resulting in colitis. in colitis.

Underneath Underneath these these changes changes areare thethe everyday everyday stressors stressors ourour horses horses endure; endure; training training all all feed feed intointo thisthis cycle, cycle, intensifying intensifying thethe underlying underlying GI GI confinement, confinement, trailering, trailering, separation, separation, andand thethe stress stress of performance of performance andand disorder. disorder.

Biophyschosocial Biophyschosocial and and Functional Functional Gastro-Intestinal Gastro-Intestinal Disease Disease in in Horses Horses

Early Early Life Life Genetics Genetics Environmental Environmental Factors Factors

Psychological Psychological Factors Factors

Outcome Outcome

Life Life Stress Stress

Quality Quality of Life of Life

Psychological Psychological State State

General General Health Health & Condition & Condition

Coping Coping Environmenal Environmenal Factors Factors

Trainability Trainability Colitis Colitis Ulcers Ulcers

Physiology Physiology

Diarrhea Diarrhea

This This cycle cycle cancan greatly greatly alter alter GI function, GI function, notnot only only affecting affecting performance performance andand overall overall condition condition butbut leading leading to various to various disorders disorders including including Leaky Leaky GutGut Syndrome.

Syndrome.

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Within Within traditional traditional management management practices practices thethe changes changes needed needed to to reverse reverse thisthis stressful stressful cycle cycle areare difficult difficult andand at times at times impossible impossible to implement. to implement.

Lack Lack of real of real estate estate andand thethe move move of horse of horse owners owners to more to more suburban suburban areas areas limit limit thethe ability ability forfor thethe horse horse to live to live in in its its natural natural state, state, on on pasture. pasture.

Some Some changes changes cancan be be made made to their to their dietdiet such such as feeding as feeding lessless concentrate, concentrate, higher higher quality quality andand freefree choice choice forage, forage, as well as well feeding feeding more more meals meals perper day. day.

Changing Changing training training andand trailering trailering routines routines may may also also help help to reduce to reduce everyday everyday these changes changes alone alone may may notnot be be enough enough to to stressors. stressors.

However, However, these improve improve thethe horse’s horse’s stress stress level level andand mitigate mitigate its its effect effect on on their their digestive digestive health. health.

Early Lif

Genetics

Environme Factors

Motility Motility Sensation Sensation Inflammation Inflammation

FGID FGID Symptoms Symptoms Behavior Behavior

Incorporating Incorporating a high-quality a high-quality digestive digestive aid,aid, such such as Secure as Secure Guard Guard Gold, Gold, intointo your your feeding feeding program program is the is the best best or only or only solution solution to to stabilizing stabilizing thethe negative negative effects effects caused caused by by thethe plethora plethora of stressors of stressors your your horses horses encounter encounter on on a regular a regular basis. basis.

Secure Secure Guard Guard Gold Gold provides provides thethe most most complete complete andand effective effective method method to resolve to resolve digestive digestive disturbance disturbance andand provide provide support support to the to the entire entire digestive digestive tract tract from from thethe stomach stomach to the to the hindgut, hindgut, helping helping your your horse horse face face daily daily digestive digestive disturbances disturbances andand look look andand feelfeel hishis or her or her best. best.

DIGESTIVE HEALTH DIGESTIVE DIGESTIVE HEALTH HEALTH SECURE GUARD GOLD SECURE SECURE GUARD GUARD GOLD GOLD THE ULTIMATE DIGESTIVE AID THE THE ULTIMATE ULTIMATE DIGESTIVE DIGESTIVE AID AID

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FAST DIGESTIVE AILMENT RELIEF: Secure Guard Gold packs a powerful punch and delivers fast digestive conditioning. Many FAST FAST DIGESTIVE DIGESTIVE AILMENT RELIEF: RELIEF: Secure Secure Guard Guard GoldGold packspacks a powerful a powerful punch punch and delivers and delivers fast digestive fast digestive conditioning. conditioning.

ManyMany owners see results in AILMENT less than one week! owners owners see results see results in less in than less than one week! one week!

ENHANCED PERFORMANCE AND WELLNESS: You don’t know how much of your horse you’ve lost to digestive health issues ENHANCED ENHANCED PERFORMANCE ANDAND WELLNESS: WELLNESS: Youhappy don’t You don’t know know howsystem how muchmuch of your of your your horse horse you’ve you’ve losttop to lost digestive digestive health health issues issues until you’vePERFORMANCE addressed the problem.

Having a calm and digestive keeps horse at the oftotheir game. until until you’ve you’ve addressed addressed the problem. the problem.

Having Having a calm a calm and happy and happy digestive digestive system system keeps keeps youryour horse horse at the attop theof top their of their game. game.

TOTAL DIGESTIVE SUPPORT: Secure Guard Gold works to support the entire digestive tract from the stomach through the TOTAL TOTAL DIGESTIVE DIGESTIVE SUPPORT: SUPPORT: Secure Secure Guard Guard GoldGold works works to is support to support the entire the entire digestive digestive tract tract fromfrom the stomach the stomach through through the the hindgut.

You can trust that your horse’s total digestive health being supported for optimal function. hindgut. hindgut.

You can You trust can trust that your that your horse’s horse’s total total digestive digestive health health is being is being supported supported for optimal for optimal function. function.

ALL-IN-ONE DIGESTIVE AID: A single ingredient won’t fix a horse’s digestive system. It takes the right combination to ensure ALL-IN-ONE ALL-IN-ONE DIGESTIVE DIGESTIVE AID:AID: A single A single ingredient ingredient won’t won’t fix a fix horse’s apairing horse’s digestive digestive system. system.

It takes It takes the right thePlus right combination combination to ensure to digestive ensure proper digestive health. Secure Guard Gold combines our proven of Secure Guard and Secure into an all-in-one proper proper health. health.

Secure Secure Guard GoldGold combines combines our our proven pairing pairing of Secure of Secure Guard Guard and Secure and Secure Plus Plus intosolution. an intoall-in-one an all-in-one digestive digestive aid.digestive It’s digestive the only product on Guard the market that blends theproven quality ingredients necessary for a complete, daily aid. It’s aid.the It’sonly the only product product on the onmarket the market that blends that blends the quality the quality ingredients ingredients necessary necessary for afor complete, a complete, dailydaily solution. solution.

This patented and veterinary approved supplement provides a powerful digestive support solution for enhanced performance ThisThis patented patented and and veterinary veterinary approved approved supplement supplement provides provides a powerful a powerful digestive digestive support support solution solution for enhanced for enhanced performance performance and conditioning.

Our proprietary psyllium process and special enteric coated pellets ensures delivery of beneficial microbes and and conditioning. conditioning.

Our Our proprietary proprietary psyllium psyllium process and and special special enteric enteric coated coated pellets pellets ensures ensures delivery delivery of beneficial of beneficial microbes microbes and ingredients.

It process addresses common ailments like colic, ulcers and more. and and ingredients. ingredients.

It addresses It addresses common common ailments ailments like colic, like colic, ulcers ulcers and and more. more.

ELIGIBLE ELIGIBLE ELIGIBLE PRODUCT PRODUCT PRODUCT References: [1] Mélo S, Santiago T, Duarte T, Abreu J, Manso H, Filho H. A Proton-Pump Inhibitor Modifies the Concentration of Digestion Biomarkers in Healthy Horses. J Eq Vet Sci 2014; 34, 11-12: 1318-1323.

References: References: [2]S,Mélo Moreaux S, J,Abreu Bowman J, Hatfield P. H, Psyllium Blood Glucose andModifies Insulin Concentrations in Horses.

J Eq Vet Sci 31,Healthy 4: 160-165.

[1] Mélo[1] Santiago S, Santiago T, Nichols Duarte T, T, Duarte T,J, Abreu Manso J, Manso H, Filho H.Filho A Proton-Pump H.Lowers A Proton-Pump Inhibitor Inhibitor Modifies the Concentration the Concentration of Digestion of Digestion Biomarkers Biomarkers in 2011; Healthy in Horses.

Horses.

J Eq VetJSci Eq Vet 2014; Sci34, 2014; 11-12: 34,1318-1323.

11-12: 1318-1323.

[3] Sand Enhanced with a Product Combining prebiotics, and Psyllium in [2] Moreaux [2] Fecal Moreaux S, Nichols S,Clearance Nichols J, Bowman J, Is Bowman J, Hatfield J, Hatfield P. Psyllium P. Psyllium Lowers Lowers Blood Probiotics, Glucose Blood Glucose and Insulin and Insulin Concentrations Concentrations inClinically Horses. in Horses.

JNormal Eq VetJHorses.

Sci Eq Vet 2011; Sci 31, 2011; 4: 160-165.

31, 4: 160-165.

[3] Fecal[3]Sand FecalClearance Sand Clearance Is Enhanced Is Enhanced with a Product with a Product Combining Combining Probiotics, Probiotics, prebiotics, prebiotics, and Psyllium and Psyllium in Clinically in Clinically NormalNormal Horses.Horses.

DIGESTIVE HEALTH SECURE GUARD SOOTHING AND POWERFUL

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SOOTHING ULCER RELIEF: Ulcer treatments can wreak havoc on any horse by throwing off the normal balance of the digestive system. Secure Guard soothes the system and is patented to ameliorate ulcers to keep your horse feeling healthy and comfortable.

IMPROVED HEALTH AND OVERALL WELLNESS: Any digestive issue can disrupt your horse’s performance and

comfort. Cinchy and irritable horses often have underlying digestive health problems. Ulcers are painful and make travel, training and riding a nightmare for your horse. Having a calm and happy digestive system keeps your horse relaxed and focused.

WHOLE DIGESTIVE SUPPORT: Secure Guard works to support the entire digestive tract from the stomach through the hindgut where additional gastric conditioning is required.

FLEXIBLE, TARGETED COVERAGE: Use Secure Guard daily for cost-effective maintenance of difficult gastric problems.

References: [1] Brendemuehl JP, Altman J, Kopp K, Blikslager A. A multi-center clinical trial utilizing a combined probiotic, prebiotic and psyllium product for the management of chronic gastrointestinal disorders (diarrhea and colic) in clinically affected horses. 2010; Novus Nutritional Brands, LLC. [2] Sykes BW, Sykes KM, Hallowell GD. Efficacy of a Combination of Apolectol, Live Yeast (Saccharomyces cerevisiae [CNCM I-1077]), and Magnesium Hydroxide in the Management of Equine Gastric Ulcer Syndrome in Thoroughbred Racehorses: A Blinded, Randomized, Placebo-Controlled Clinical Trial. J Eq Vet Sci 2014; 34, 11-12: 1274-1278

DIGESTIVE HEALTH THE SECURE SYSTEM RESEARCH PROVEN

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64 equine veterinarians and owners throughout the United States volunteered 144 horses with challenging gastrointestinal disorders to be enrolled in a research trial using the commercially available and patented Secure System. The cases were chronic or recurrent and trial periods were variable and limited for each particular digestive disorder. The trial established expectations for resolution within these limited feeding periods.

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RESULTS 100% of horses with recurrent colic had shown a decrease in frequency of episodes.

Horses saw an average of 90% fewer colics within the initial treatment period.

80% of horses with chronic diarrhea were fully resolved or improved in 30 days.

81% of horses suspected with gastric ulcers were resolved or improved in 60 days.

100% of horses with sand accumulation were resolved or improved in 45 days.

94% of horses with poor body condition or weight loss were resolved or improved based on desired weight in 60 days.

TAKE HOME Treatment during a relatively short term research trial has shown The Secure System of digestive aids to be excellent support products for both challenging digestive cases as well as regular daily support with proper dosing and duration.

Improvement and resolution has been seen in all forms of digestive health issues including horses with chronic gastrointestinal disorders, particularly recurrent colic, chronic diarrhea, weight loss, and motility disturbances.

Reference: [1] Brendemuehl JP, Altman J, Kopp K, Blikslager A. A multi-center clinical trial utilizing a combined probiotic, prebiotic and psyllium product for the management of chronic gastrointestinal disorders (diarrhea and colic) in clinically affected horses. 2010; Novus Nutritional Brands, LLC.

COLIC ASSURANCE PROGRAM

OUR COLIC COVERAGE PRODUCT GUARANTEE

Up to $15,000 in coverage

Coverage for horses with PRIOR HISTORY OF COLIC*

Coverage for horses with one abdominal surgery

Coverage for multiple colic incidents

MEDICAL and SURGICAL colic coverage

Coverage while horses are TRAVELING INTERNATIONALLY*

PURCHASING directly through Arenus, veterinarians or veterinary clinics for program eligible products

NO AGE RESTRICTIONS once horses are weaned

NO LIMIT on the number of horses an owner can enroll

Coverage for LEASED HORSES

*Some restrictions and requirements may apply.

ENROLLING IS EASY! 1

Head to arenus.ca and complete the CAP enrollment form.

2

Choose your product: Secure Secure Guard

3

Wait for your final approval email & make your initial purchase.

4

Begin feeding based on your horse’s tailored Wellness Program.

Note: If you plan on enrolling in our Colic Assurance Program extensive coverage and you have already made an initial purchase, the label feeding instructions are for general digestive health. Feeding and loading dose requirements of the Colic Assurance Program may be different from label instructions and are specifically designed to help eliminate any risk of colic. Inquire or enroll soon to access your custom feeding program.

RESPIRATORY AND IMMUNE SYSTEM HEALTH RESPIRATORY AND IMMUNE SUPPORT DHA—THE RIGHT OMEGA-3 FATTY ACID

When it comes to Omega-3 products, not all are created equal. This is because not all Omega-3s contain DHA, one of the most beneficial, natural Long Chain Omega-3 Fatty Acids. DHA provides advanced cellular support for reproductive, respiratory and immune health.

Omega-3 supplements commonly source their Omega-3 Fatty Acids from low-DHA fish oil or non-DHA flaxseed.

These sources do little to support your horse’s respiratory and immune health. Fish oil also exposes horses to the risk of heavy metal toxicity. Flaxseeds, although vegetarian, don’t provide the right type of Omega-3 Fatty Acids to optimally support respiratory and immune functions, yet can be of benefit to other body systems.

Our Omega-3 products are made from the same, safe algae-derived DHA used in human infant formula. As herbivores, horses are able to naturally absorb this bioavailable, algal-DHA for maximum health benefits.

This is why we use it as the base of our respiratory and reproductive health supplements. Aleira is a unique blend of algal-DHA, antioxidant-rich mushrooms, vitamin C and MSM. This effective combo addresses inflammation and immune responses for horses with a range of respiratory issues.

THE STRUGGLE TO BREATHE Stall confinement. Tighter living quarters. Travel and trailering. Indoor exercise and dusty arenas.

All of these factors have led to a significant increase in allergic reactions and low level respiratory disease. More horses than ever before show symptoms of low level cough, drippy noses and low level breathing difficulties due to the early effects of airway inflammation. These horses need daily support instead of a medical treatment alone.

David Ziegler Arenus Ambassador “Aleira’s use as a therapy in both acute and chronic cases has impressed me to the degree that it has become a go to product in my practice and one that I highly recommend. In EIPH, IAD and severe dermatitis cases, Aleira has been a great success as an adjunctive therapy. A grand prix jumper I worked with who suffered from severe, chronic EIPH on a daily basis, showed marked clinical improvement after 45 days on Aleira. Other therapies and treatments had been unsuccessful in this horse. This is one of the many cases where I have witnessed significant improvement while using Aleira.”

Even when it comes to severe respiratory disease issues such as Heaves or Inflammatory Airway Disease (IAD), anti-inflammatories and steroids are not always the best answer. Like a band-aid they offer a quick fix and at times are very necessary, but often don’t get to the root of the problem. Cellular support addresses the underlying issue and offers consistent, daily maintenance.

Years of research by our veterinarians and nutritionists have resulted in an algal-DHA based formula that makes a dramatic difference in horses with breathing and allergy challenges. Our formula can also be safely used in conjunction with traditional treatments. In many cases, horses are able to be supported on Aleira alone. If your horse is a bleeder or struggles with other respiratory or immune problems, then Aleira is the answer you’ve been waiting for.

Meg Miller-Turpin

DVM, DACVIM

7

RESPIRATORY AND IMMUNE SYSTEM HEALTH RESPIRATORY AND IMMUNE SYSTEM HEALTH ALEIRA ALEIRA RESEARCHED RESPIRATORY AND IMMUNE SUPPORT RESEARCHED RESPIRATORY AND IMMUNE SUPPORT

*XXJSYNFQ WJXUNWFYTW^ XZUUTWY &QJNWF MJQUX *XXJSYNFQ WJXUNWFYTW^ XZUUTWY &QJNWF MJQUX RFNSYFNS TUYNRFQ WJXUNWFYTW^ KZSHYNTS NS RFNSYFNS TUYNRFQ WJXUNWFYTW^ KZSHYNTS NS F IFNQ^ STS RJINHFYJI XZUUQJRJSY F IFNQ^ STS RJINHFYJI XZUUQJRJSY

IMPROVED PERFORMANCE: Addressing airway challenges keeps your horse comfortable and at the top of their game. Aleira IMPROVED PERFORMANCE: Addressing challenges keepsresponses. your horseAleira comfortable and at the top of their game. Aleira offers effective support for bleeders and horses with airway respiratory or immune combats performance offers conditions effective support for bleeders andObstruction horses with(RAO), respiratory or immune responses.

Aleira combats performance limiting like Recurrent Airway Inflammatory Airway Disease (IAD), allergies, hives and dermatitis. limiting conditions like Recurrent Airway Obstruction (RAO), Inflammatory Airway Disease (IAD), allergies, hives and dermatitis.

NON-MEDICINAL ALTERNATIVE: Powerful respiratory support without the negative side effects of traditional treatments ALTERNATIVE: Powerful respiratory support the negative side effects traditional likeNON-MEDICINAL steroids. Safe for horses that are sensitive to traditional medications.

In without many cases, horses using Aleiraof are able to betreatments supported steroids. onlike Aleira alone!Safe for horses that are sensitive to traditional medications. In many cases, horses using Aleira are able to be supported on Aleira alone!

SAFE TO USE: Can be safely combined with conventional treatments for additional respiratory health support. Safe for long-term SAFE TO USE: Can be safely combined with conventional treatments for additional respiratory health support. Safe for long-term maintenance. maintenance.

Our research-proven formula combines algal-DHA, an immune-modulating and anti-inflammatory proprietary Mushroom Blend, Our research-proven formula combines algal-DHA, an immune-modulating and anti-inflammatory proprietary Mushroom Blend, Vitamin C and MSM into a powerful supplement. It addresses inflammation and immune responses for horses with a range of Vitamin C and MSM into a powerful supplement. It addresses inflammation and immune responses for horses with a range of respiratory issues. respiratory issues.

Reference: [Nogradi N, Couetil LL, Messick J, Stochelski MA, Burgess JA. Evaluation of an Omega-3 Fatty Acid Containing Feed Supplement in the Management of Horses with Chronic Lower Airway Inflammatory Reference: N, 2015; Couetil LL, Messick J, Stochelski MA, Burgess JA. Evaluation of an Omega-3 Fatty Acid Containing Feed Supplement in the Management of Horses with Chronic Lower Airway Inflammatory Diseases.

J Vet [Nogradi Intern Med 29: 299-306.

Diseases. J Vet Intern Med 2015; 29: 299-306.

“Managing “Managingequine equineasthma asthma (RAO (RAO and and IAD) IAD) cases caseshas hasbeen beeneasier easierthanks thanks to toAleira.

Aleira. After After research researchin inmy mylab labas aswell well as as recommending recommending ititfor foruse usein inthe thefield, field,II have have found found Aleira Aleira to tobe beaavaluable valuabletool toolin in managing managing difficult difficult respiratory respiratorycases. cases.My My goal goal is is to to reduce reduce equine equineasthma asthmaburden burden and and find find aa cure cure that that would wouldreduce reducethe thereliance reliance on on prescription prescription drugs, drugs,especially especiallysteroids, steroids, in in managing managing these thesecases. cases.ItItisishelpful helpful to to horse horse owners owners and andveterinarians veterinariansto tohave have at at their their disposal disposal aanon-drug non-drugtherapy therapythat that has has proven proven efficacy efficacy and andisiseasy easyto toadminister. administer. II have have many many cases casesthat thatare arenow nowwell well controlled controlled by by proper proper management managementof ofenvironmental environmental conditions conditions and andreplacing replacingor orreducing reducing drugs drugs with with Aleira.”

Aleira.”

Laurent LaurentCouetil Couetil DVM, DVM,DACVIM, DACVIM,PhD PhD

RESPI

RESPIRATORY AND IMMUNE SYSTEM HEALTH

ALEIR RESE

ALEIRA RESEARCH PROVEN

STUDY OV

STUDY OVERVIEW

This study w formulation o conducted at horses with c laboratory an

This study was designed to examine the effects of ALEIRA® on coughing, respiratory effort and performance. Aleira is a patented formulation of ingredients including a specific and purified omega-3 fatty acid, DHA (docosahexaenoic acid). Through the research conducted at the Purdue University College of Veterinary Medicine, Aleira was fed in conjunction with a low dust diet to 35 client-owned horses with chronic inflammatory diseases both recurrent airway obstruction (RAO) and inflammatory airway disease (IAD). Evaluation of laboratory and clinical parameters were made as well as assessment of daily on farm performance and results.

RESULT

RESULTS

Overa clinicia increa VAS c signifi The ef The ef The ef The ef Aleira placeb Aleira Aleira

Overall, both clinician assigned VAS scores and owner assigned VAS scores improved 8 weeks in to the trial however, the clinician assigned VAS receiving Aleira supplementation reached statistical significance. Placebo clinician assigned VAS score increase was not significant.

VAS cough scores improved significantly in all 3 treatment groups but horses with 1 times per day dose of DHA exhibited a significantly higher VAS score 2 months later than placebo.

The effect of Aleira supplementation and pelleted feed on VAS scores was noticeable first at 2 weeks.

The effects of Aleira supplementation and pelleted feed reached maximum benefit for coughing between weeks 2 and 5.

The effects of Aleira supplementation and pelleted feed reached maximum effect for respiratory effort between weeks 5 and 6.

The effects of Aleira supplementation and pelleted feed reached maximum effect for poor performance between weeks 3 and 5.

Aleira Supplementation for 2 months resulted in a significant reduction in neutrophils in BALF which was not observed in placebo fed horses.

Aleira Supplementation for 2 months saw a significant improvement in lung function in horses supplemented with DHA. Aleira Supplementation for 2 months resulted in a 10-fold increase in plasma DHA levels. No other fatty acid was affected.

rr g g

TAKE H

TAKE HOME

Supplem improvem the place

Supplementation of ALEIRA to horses with RAO or IAD, in combination with a complete pelleted feed, showed significant improvement in clinical signs, including cough, respiratory effort and performance as well as lung function and BALF compared to the placebo group.

yy

r

”

Reference: Nogradi N, Couetil L disease. J Vet Intern

Reference: Nogradi N, Couetil LL, Messick J, Stochelski MA, Burgess JR. Omega-3 fatty acid supplementation provides an additional benefit to a low-dust diet in the management of horses with chronic lower airway inflammatory disease. J Vet Intern Med. 2015; 29(1): 299-306.

REPRODUCTIVE HEALTH REPRODUCTIVE HEALTH FOR ALL DHA—THE RIGHT OMEGA-3 FATTY ACID SOURCE ADDRESSING TODAY’S REPRODUCTIVE CHALLENGES Low conception rates. Mares taking multiple cycles to become pregnant or not conceiving for the year at all. Stallions with low sperm counts, poor quality and motility. Late-born, smaller foals at a disadvantage in yearling sales and competition.

These are some of the most pressing challenges in today’s breeding industry. These common reproductive issues are reduced with the help of a good DHA and cellular support supplement.

We developed Releira because there were no supplements available to help mares with fertility issues. There were only a few designed for stallions, but the reproductive health of mares was being ignored. Our research-proven formula offers a unique solution for a wide range of reproductive health issues, including problems with difficult mares. Supplementing with Releira helps mares that have difficulty conceiving become pregnant in fewer cycles. It reduces post-breeding uterine inflammation and fluids for higher pregnancy rates and it safely supports the mare and foal throughout gestation.

The same supplement can be fed to stallions to improve fertility. Pure algal-DHA works to not only increase sperm production, but to improve the quality of the cellular structure and progressive motility of the sperm for successful AI and live cover breedings. Even stallions with normal sperm counts often have numbers dip mid-season. Releira keeps numbers high throughout the entire season and improves numbers in stallions with low counts.

DHA improves molecular development of foals, creating a better cell membrane and more foals carried to term. Studies have proven that foals of mares supplemented with Releira have increased cognitive function and trainability. This is because quality DHA transfers to the foal during gestation and nursing.

If you’re ready for a more productive breeding season, try Releira. Our algal-DHA, research-proven formula is the solution for today’s most common fertility challenges in mares and stallions.

“I conducted a controlled trial utilizing a very robust frozen semen challenge that demonstrated a significant influence of supplementation with Releira on reducing the post breeding inflammatory response in all classes of mares.

A subsequent clinical trial involving thoroughbred mares and stallions in a commercial breeding environment further demonstrated the benefits of Releira in reducing breeding induced inflammation and improving per cycle pregnancy rates.”

Jim Brendemuehl DVM, PhD, DACT

REPRO

REPRODUCTIVE HEALTH

RELE ESSE

RELEIRA ESSENTIAL REPRODUCTIVE SUPPORT

Essential reproductive support, Releira helps mares and stallions reach their full breeding potential in a daily, DHA supplement. This research-backed Omega-3 formula provides reproductive health benefits for mares, stallions, and foals. It addresses common fertility issues with a readily-absorbed, vegetarian algae source.

KEY BENEFITS FOR MARES: Success in fewer cycles: Releira significantly improves conception rates in broodmares with a history of complications. Our DHA helps difficult mares that are typically bred in three to seven cycles to become pregnant in one cycle.

Reduced costs: Mares that don’t become pregnant still need care and resources. Quicker, successful pregnancies reduce the expenses for unbred mares and eliminates the missed opportunity of not having a foal to sell or compete with for another year.

Improved conception rates: Releira reduces post-breeding uterine inflammation and fluids for higher pregnancy rates.

Support throughout pregnancy: Safely provides constant reproductive support throughout the entire gestation period.

KEY BENEFITS FOR STALLIONS:

RESEARCH PROVEN The goal of this study was to determine if a significant difference existed in the uterine inflammatory response to frozen semen in response to supplementation with a blended algal and flaxseed source (RELEIRA) of the omega-3 fatty acid DHA. 15 mixed breed horses were used in the study. 10 mares were classified as resistant based upon uterine biopsy scores of I-A or I-B and ability to clear all mating induced endometritis at 24 hours post insemination. 5 mares were classified as susceptible with uterine biopsy scores of II-B or III and the presence of uterine hyperechoic fluid at 24 hours post insemination.

Boosts fertility: Improves pregnancy rates from stallions with a history of common fertility issues.

Increased sperm count: Stallions with normal sperm counts often have numbers dip mid-season. Releira keeps numbers high throughout the entire season and improves numbers in stallions with low counts.

Improved sperm quality and motility: Pure DHA works to not only increase sperm production, but to improve the quality and motility of the sperm for successful AI and live cover breedings.

R

KEY BENEFITS FOR FOALS: More live foals: DHA improves molecular development. This creates a better cell membrane and more foals carried to term.

Less late season foals: Mares bred in fewer cycles result in foals born on time.

Late-born, smaller foals are at a disadvantage against older foals in yearling sales and competition.

Improved cognitive health: Studies have proven that foals of mares supplemented with Releira have increased cognitive function and trainability.

Quality DHA transfers to the foal during gestation and nursing.

The goal significa inflamm response to and flaxseed acid DHA. 15 study. 10 m upon uterine to clear al hours post i as susceptib III and the p 2

RESULTS

RESULTS

A very signi Plasma DHA The inflamm resistant an

A very significant reduction in uterine fluid accumulation and neutrophil infiltration was noted in the five mares classified as susceptible.

Plasma DHA levels were significantly higher at day 28 and day 60 as compared to day 0.

The inflammatory response, as indicated by uterine fluid presence and neutrophil infiltration, was significantly reduced at 12 and 24 hours in both resistant and susceptible mares fed RELEIRA for 63+ days. ®

TAKE HOM

TAKE HOME

Oral suppleme semen.

Oral supplementation of RELEIRA given to susceptible and resistant mares significantly reduced the post breeding inflammatory response to frozen semen. ®

References: [1] Brendemuehl JP, Altman J, Kopp K. Influence of dietary algal N-3 fatty acids on breeding induced inflammation and endometrial cytokine expression in mares bred with frozen semen. J Equine Vet Sci. 2014; 34(1):123-124.

[2] J Equine Vet Sci. 2014; 34(1):123-124. Adkin AM, Warren LK, McCall CA. Effect of maternal docosahexaenoic acid supplementation on behavior and cognitive development in nursing foals. J Equine Vet Sci. 2013; 33(5):363. Hansen TL, Adkin AM, Warren LK. Effect of early exposure to maternal docosahexaenoic acid on memory and cognition in weaned foals. J Equine Vet Sci. 2013; 33: 364. Adkin AM, Muniz AV, Mortensen CJ, Warren LK. Maternal fatty acid supplementation influences memory and learning ability in yearling and 2-year-old horses. J Equine Vet Sci. 2015; 35: 419.

References: [1] Brendemuehl JP, 34(1):123-124.

[2] J Equine Vet Sci. 33(5):363. Hansen TL Warren LK. Maternal

STRUCTURAL STRUCTURAL HEALTH HEALTH ORTHOPEDIC ORTHOPEDICSUPPORT SUPPORT SOFT TISSUE SUPPORT SOFT TISSUE SUPPORTYOU YOU CAN CAN TRUST TRUST THE THEDAILY DAILYRISK RISKOF OFORTHOPEDIC ORTHOPEDICINJURY INJURY The daily physical demands in new new challenges challenges for forour ourequine equine The daily physical demandson onperformance performancehorses horsesand andchanges changesin inmodern modern footing footing have have resulted resulted in athletes.

Soft surfaces diseases like like osteoarthritis osteoarthritis athletes.

Soft surfacesand anddeeper deeperfooting footingputs putshorses horsesatatincreased increasedrisk riskof of soft soft tissue tissue injuries. injuries. Orthopedic Orthopedic diseases only add toto the problem. only add the problem.

But it takes more than protection from from tendon, tendon,ligament, ligament, But it takes more thantraditional traditionaljoint jointsupport supporttotoprotect protectour ourhorses. horses.Today’s Today’s athletes athletes need need broader broader protection joint capsule, muscular joint capsule, muscularand andsoft softtissue tissuedamages. damages.

Equestrians today must control small, small, undetected undetectedstrains strains Equestrians today mustfind findand anduse usethe thebest besttools toolsavailable availableto toavoid avoidmajor major soft soft tissue tissue injuries injuries and and control and sprains before they nutritional support supportand andtopicals topicalsto to and sprains before theybecome becomea amajor majorproblem. problem.This Thisisisthe thereason reasonit’s it’scrucial crucial for for riders riders to use great nutritional protect their horses. protect their horses.

Our Steadfast line goes bone and and soft soft tissue tissuehealth, health, Our Steadfast line goesbeyond beyondthe theabilities abilitiesofoftraditional traditionaljoint jointsupplements. supplements. Most Most supplements supplements ignore bone leaving your horse exposed Steadfast formulas formulas offer offertotal total leaving your horse exposedtotoa avariety varietyofofpainful painfulor orcareer-ending career-endinginjuries. injuries. Our Our clinically clinically proven Steadfast structural support for structural support forthe themost mostcomprehensive comprehensiveprotection protectionavailable availabletoday. today.

“RC “RC Fancy Fancy Step Stephas hasbeen been great his entire great his entirecareer career and and he he seems seemsto tobe be getting better with age. getting better with age.

We We attribute attribute some someof ofhis his success to using a great success to using a great product like Steadfast product like Steadfast Equine. I also use Equine. I also use Steadfast Equine on some Steadfast Equine on some of my derby horses and all of my derby horses and all of my futurity horses.” of my futurity horses.”

Shawn Flarida Shawn Flarida NRHA Champion NRHA Champion and Arenus Ambassador and Arenus Ambassador

STRUC

STRUCTURAL HEALTH

STEA COMP

STEADFAST EQUINE PERFORMANCE COMPLETE ORTHOPEDIC SUPPORT

Steadfast Equine Performance protects and preserves your horse’s joint health to extend their career and keep them comfortable in training and competition.

No other equine joint supplement offers the unique formulation and scientific backing of Steadfast Equine Performance.

2X NATUR

2X NATURAL PROTEIN NEM: Each packet of Steadfast Equine Performance contains a double dose of NEM compared to our

original form are synthetic structural sup In a human s

original formula. Natural Eggshell Membrane provides a naturally occurring matrix of joint and structural support components that are synthetically manufactured in other supplements. NEM is a natural protein source that’s easily absorbed by horses for maximum structural support benefits. NEM results are proven more effective and faster acting than using traditional chondroitin and glucosamine.

In a human study, NEM provided significant improvement to knee and hip osteoarthritis pain and stiffness within 10 days [1].

HIGH LEV

HIGH LEVEL PERFORMANCE PROTECTION: The lifestyle of equine athletes is stressful on joints, soft tissue and bone.

Heavy trainin chronic pain. comfortable

Heavy training schedules, regular competition, frequent travel and uneven footing can lead to career-altering soft tissue injuries and chronic pain. Steadfast Equine Performance protects and preserves your horse’s joint health to extend their career and keep them comfortable in training and competition.

IMPROVE

IMPROVED MOTION AND FLEXIBILITY: Performance horses with stiff, painful movement need total structural support for

relief and com feel better fo

relief and comfort. Steadfast Equine Performance works fast with a powerful dose of Natural Eggshell Membrane to make your horse feel better for a longer stride length and more fluid motion.

RAPID RE

RAPID REPAIR AND PREVENTION: Horses on Steadfast Equine Performance have the structural support to avoid time

consuming a prevent injur

consuming and costly soft tissue injuries. Increased bone density, tendon strength, ligament strength and healthier soft tissues help prevent injury. Horses in training and competition need maximum support to keep them feeling and performing at their best.

TOTAL ST

TOTAL STRUCTURAL AID: Complete structural support for healthy joints, soft tissue and bones. Made with the highest level

of naturally o unique formu

of naturally occurring glucosamine, chondroitin, collagen and hyaluronic acid available. No other equine joint supplement offers the unique formulation and scientific backing of Steadfast Equine Performance.

PRE-MEA

PRE-MEASURED SINGLE DAILY PACKETS: Convenient, daily dose pouches come pre-measured for easy feeding and

storage. No n support in a s

storage. No need to use two packets for a loading dose or during times of added stress. Your horse receives the maximum level of joint support in a single packet. Easy to travel with or store.

NEM is a registered mark

References: [1] Danesch U, Seybold M [2] Dibner JJ, Quiroz MLM [3] Zhao J, Harrell R, Grei [4] Wedekind KJ, Coverda eggshell membrane), as d

NEM is a registered mark of ESM Technologies, LLC References: [1] Danesch U, Seybold M, Rittinghausen R, Treibel W, Bitterlich N. NEM® Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study. J Arthritis. 2014; 3: 136.

[2] Dibner JJ, Quiroz MLM, Richards JD. Benefit of MINTREX P blend or organic trace minerals on the tibial dyschondroplasia, synovitis and pododermatitis in heavy weight tom turkeys. Abstract presented at: Poultry Science; July 16-19; 2006; Edmonton, Alberta.

[3] Zhao J, Harrell R, Greiner L, Allee G, Knight C.. Chelated trace minerals support sow reproduction. Feedstuffs. 2012; 84: 86-28.

[4] Wedekind KJ, Coverdale JA, Hampton, TR, Atwell CA, Sorbet RH, Lunnemann J, Harrell RJ, Greiner L, Keith NK, Evans JL, Zhao J, Knight CD. Efficacy of an equine joint supplement, and the synergistic effect of its active ingredients (chelated trace minerals and natural eggshell membrane), as demonstrated in equine, swine and an osteoarthritis rat model. Animal Physiology. 2015; 7: 13-

STRUCTURAL STRUCTURAL HEALTH HEALTH STEADFAST EQUINE STEADFAST EQUINE COMPLETE ORTHOPEDIC SUPPORT COMPLETE ORTHOPEDIC SUPPORT

More than a joint supplement, Steadfast Equine More than a joint supplement, Steadfast Equine offers complete structural support for all horses. offers complete structural support for all horses.

The patented formula contains Natural Eggshell The patented formula contains Natural Eggshell Membrane (NEM ) and TêlaFIRM. Membrane (NEM ) and TêlaFIRM. ® ®

These proprietary ingredients combine to These proprietary ingredients combine to provide your horse with a bioavailable source of provide your horse with a bioavailable source of glucosamine, chondroitin, collagen, hyaluronic acid glucosamine, chondroitin, collagen, hyaluronic acid and chelated minerals for maximum joint and soft and chelated minerals for maximum joint and soft tissue support and performance recovery. tissue support and performance recovery.

IMPROVED MOTION AND FLEXIBILITY: Horses with stiff, painful movement need total structural support for relief and Horses stiff, need total structural support for relief and IMPROVED MOTION AND FLEXIBILITY: comfort. Steadfast Equine works fast to make your horse feel with better for painful a longermovement stride length and more fluid motion. comfort. Steadfast Equine works fast to make your horse feel better for a longer stride length and more fluid motion.

REPAIR AND PREVENTION: Horses on Steadfast Equine have the structural support to avoid time consuming and costly soft REPAIR AND PREVENTION: Steadfast Equine strength have theand structural support to avoid time consuming tissue injuries.

Increased bone density,Horses tendonon strength, ligament healthier soft tissues help prevent injury.and costly soft tissue injuries. Increased bone density, tendon strength, ligament strength and healthier soft tissues help prevent injury.

ACTIVE HORSE SUPPORT: The lifestyle of a performance horse is stressful on joints, soft tissue and bone. Preserve your The lifestyle of them a performance horse is stressful joints, soft tissue and bone. Preserve your ACTIVE horse’s jointHORSE health to SUPPORT: extend their career and keep comfortable in training andon competition. horse’s joint health to extend their career and keep them comfortable in training and competition.

SENIOR SUPPORT: Horses of all ages benefit from structural support maintenance. Arthritic and aging horses have additional SENIOR SUPPORT: Horsessupport of all ages structural support maintenance. andyounger aging horses have agile. additional stress on their joints that require for benefit optimalfrom health.

Steadfast Equine helps seniorArthritic horses feel and more stress on their joints that require support for optimal health. Steadfast Equine helps senior horses feel younger and more agile.

PRE-MEASURED POUCHES: Convenient, daily dose pouches come pre-measured for easy feeding and storage.

PRE-MEASURED POUCHES: Convenient, daily dose pouches come pre-measured for easy feeding and storage.

TOTAL STRUCTURAL AID: Complete structural support. No other equine joint supplement available offers the unique TOTAL STRUCTURAL AID:ofComplete formulation and scientific backing Steadfaststructural Equine. support. No other equine joint supplement available offers the unique formulation and scientific backing of Steadfast Equine.

RESEARCH PROVEN RESEARCH PROVEN

16 mature horses with OA were fed STEADFAST® Equine or a placebo for 42 days. Blood was collected every two weeks and levels of the biomarkers 16 mature horses with OA were fedmeasured.

STEADFAST® Equine or aisplacebo for 42ofdays.

Blood was collected every weeks and levels of theand biomarkers CTXII, PIIANP , and osteocalcin were CTXII collagen a byproduct cartilage breakdown, PIIANP is atwo protein found in cartilage blood CTXII, PIIANP , and cartilage osteocalcin were measured.

CTXII collagen is a byproduct of cartilage breakdown, PIIANP isincreases a protein suggest found inchondromodulation. cartilage and blood increases indicate regeneration while the protein osteocalcin is important in bone mineralization and increases indicate cartilage regeneration while the protein osteocalcin is important in bone mineralization and increases suggest chondromodulation.

The decrease in serum CTXII and increase in serum PIIANP and The decrease in serum CTXII of and increase in serum PIIANP and osteocalcin suggest slowing cartilage loss and rebuilding of osteocalcin slowing of cartilage loss and rebuilding cartilage andsuggest bone tissue in horses fed STEADFAST® Equine.of cartilage and bone tissue in horses fed STEADFAST® Equine.

References: [1] Wedekind KJ, Coverdale JA, Hampton, TR, Atwell CA, Sorbet RH, Lunnemann J, Harrell RJ, Greiner References: L, Keith NK, Evans [1] Wedekind KJ, Coverdale JA, Hampton, TR, Atwell CA, Sorbet RH, Lunnemann J, Harrell RJ, Greiner [2] JL, Zhao J, Knight CD. Efficacy of an equine joint supplement, and the synergistic effect of its active L, Keith NK, Evans ingredients minerals naturaljoint eggshell membrane), as demonstrated in equine, [2] JL, Zhao (chelated J, Knight trace CD. Efficacy of and an equine supplement, and the synergistic effect of its active swine and an osteoarthritis rat model.

Animal Physiology.

2015; 7: 13-27. ingredients (chelated trace minerals and natural eggshell membrane), as demonstrated in equine, swine and an osteoarthritis rat model. Animal Physiology. 2015; 7: 13-27.

PROVEN PAIN RELIEF

SORE NO-MORE

SNM RESE

SNM RESEARCH-BACKED PAIN RELIEF

STUDY OV

STUDY OVERVIEW

This study w available, he reducing pain Truman State to either a So Back pain sco pressure forc

This study was designed to evaluate the effectiveness of a commercially available, herbal, nonheating liniment, Sore No-More Performance Ultra, in reducing pain and inflammation in horses with mild back pain. Conducted at Truman State University, 18 university-owned horses were randomly assigned to either a Sore No-More Performance Ultra treatment group or control group.

Back pain scores in both groups were evaluated regularly over 44 days with a pressure force gauge.

Average Pain Score for Area Treated with Sore No-More® Performance Ultra on Right Side

Average Pain Score for Area Treated with Sore No-More® Performance Ultra on Left Side

Sore No-More® Performance Ultra

Sore No-More® Performance Ultra

Control

Control 4.0

4.0

#

3.5

3.0

Average Pain Score (0 to 13 Scale)

Average Pain Score (0 to 13 Scale)

3.5

2.5 2.0

*

1.5

3.0 2.5 2.0 1.5 1.0

1.0

0.5

0.5 0.0

PROVE

0.0 2

9

16

23

30

Day of Treatment

37

44

2

9

16

23

30

37

44

Day of Treatment

A As published in the Journal of Animal Science

RESULT

RESULTS

Overa the tri

Overall, horses in the treatment group had a statistically significant decrease in pain score from the beginning to the end of the trial (44 days total).

Horses in the treatment group had a 2.87 decrease in pain score compared to a 0.72 decrease in pain score in the control group.

Therm exerci

Thermal imaging also demonstrated a significant impact on temperature readings both at the time of the trial as well as after exercise and application of Performance Ultra.

Near t

Near the end of 30 days, horses in the treatment group had a lower average back temperature.

TAKE H

TAKE HOME

Horses tr

Horses treated with Sore-No-More Performance Ultra showed decreased back pain scores within the first two days of treatment.

Reference: Walter, K.W., Altman

Reference: Walter, K.W., Altman, J. & Haussler, K.(2023) Reducing chronic back pain and inflammation in horses using a commercial herbal liniment. Equine Veterinary Education, 35, e499-e506.

Horse

PROVEN PROVEN PAIN PAIN RELIEF RELIEF

SORE SORE NO-MORE NO-MORE

SNM SNM RESEARCH-BACKED RESEARCH-BACKED PAIN PAIN RELIEF RELIEF For over 25 years, SNM has been the trusted For overof25 years, SNM has been theequine trusted source pain relief for professional source of pain relief for professional equine athletes, trainers, therapists, and veterinarians. athletes, trainers, therapists, and veterinarians.

PERFORMANCE PERFORMANCE

SNM provides potent pain relief, targeting inflammation at the SNM pain relief, inflammation at the sourceprovides with its potent proprietary blend targeting of all natural herbs. source with its proprietary blend of all natural herbs.

Daily use formulation Daily use formulation Soothing antiSoothing antiinflammatory inflammatory Use before and after rides Use beforeprevention and after rides for injury for injury prevention FEI compliant FEI compliant

Our herbs are carefully chosen, extracted and monitored for purity Our are No carefully extracted monitored for purity and herbs strength. harsh chosen, chemicals such as and menthol or capsaicin andused strength.

No harsh chemicals such as menthol or capsaicin are in our formula. are used in our formula.

SNM can help put a stop to the never-ending cycle of soreness, SNM can help a stop to the cycleon of soreness, tiredness, and put inflammation thatnever-ending can wreak havoc muscles, tiredness, that can wreak havoc on muscles, ligaments,and andinflammation other soft tissue. ligaments, and other soft tissue.

PERFORMANCE ULTRA PERFORMANCE ULTRA Clinical strength version of Clinical strength version of SNM SNM Most powerful & fastestMost & fastestactingpowerful SNM product acting SNM product Soothing long lasting antiSoothing long lasting antiinflammatory inflammatory FEI compliant FEI compliant “My 8 year-old gelding slipped real bad at a barrel race “My 8 ayear-old gelding real area bad at barrel about month ago andslipped his lumbar in ahis backrace got real abouttoatouch monthand agothe and his lumbar area in hisgot back real sore points of his shoulders biggot knots sore to touch points of adjust his shoulders big knots in them.

I hadand my the chiropractor him andgot I started in them. had my chiropractor adjust him and I started using theI SNM Performance Ultra Gelotion daily after using the and SNMwithin Performance Ultra muscles Gelotionbegan daily after workouts 3 days those to soften. workouts and made withinit3adays began”to soften.

I’ve since just part those of my muscles daily regimen.

I’ve since just made it a part of my daily regimen.”

Lynnzie Lindstrom, Arenus Ambassador, Lynnzie Lindstrom, Arenus Ambassador, World Champion Barrel Racer World Champion Barrel Racer

“I like to use the SNM Gelotion on all of my horses after a “I likeday to use thearena.

SNM SNM Gelotion ongo-to all offavorite my horses after a long in the is my because long daytoinrelax the arena.

SNM sore is mymuscles go-to favorite because it helps and relieve and fatigue.

The it helps towith relax relieve sore muscles fatigue.

Gelotion itsand thicker consistency helpsand to keep theThe back Gelotion nice withand its thicker consistency helpsmy to horses keep the back muscles soft. Using SNM keeps musclesgood!” nice and soft. Using SNM keeps my horses feeling feeling good!”

Shawn Flarida, Arenus Ambassador, NRHA Reiner Shawn Flarida, Arenus Ambassador, NRHA Reiner

-David Ziegler, Professional Dressage Rider

-David Ziegler, Professional Dressage Rider

“Every horse I own, or train uses SNM products daily, “Every because horse I own, or train uses SNM daily, simply there’s no question theyproducts work and are simply noon question they We work areour the bestbecause linimentthere’s product the market. alland want the bestnice liniment product themuscles market.and We all want ourme horses and supple in on their SNM helps horses and supple in their muscles and SNM helps get that.nice A horse that feels good will give you his all andme get that.

A horse that feels goodbest. will”give you his all and SNM makes sure they feel their SNM makes sure they feel their best.”

David Ziegler, Arenus Ambassador David Ziegler,Dressage Arenus Ambassador Professional Rider Professional Dressage Rider

USING THE PRODUCTS USING THE PRODUCTS LINIMENT LINIMENT

· Great for sensitive skin · Great for sensitive skin · Can be sprayed on or rubbed in · Can be sprayed on or rubbed in · Safe to use on entire body ·· Safe to diluted use on entire bodybrace Can be for a body · Can be diluted for a body brace

GELOTION GELOTION

· Slightly thicker consistency to make it easy · to Slightly consistency to make it easy apply thicker to hard-to-reach areas to apply to hard-to-reach areas · Safe to use on entire body · Safe to use on entire body

POULTICE POULTICE

· Ideal for use on lower limbs · Ideal for use on lower limbs · Pair with or without wraps, paper or plastic · Pair with or without wraps, paper or plastic · Effective at pulling out heat and swelling · Effective at pulling out heat and swelling

ARENUS ANIMAL HEALTH ARENUS ANIMAL HEALTH

Order directly from ARENUS.CA or call us at: 866-791-3344.

Order directly from ARENUS.CA or call us at: 866-791-3344.