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(Ref-1) dependent activator protein-1 (AP-1) (a heterodimer of c-Fos and c-Jun), nuclear factor kappa B (NF-ÎşB), p53 activating transcription factor/cAMP-response elementbinding protein (ATF/CREB) and hypoxiainducible factor (HIF)-1.6 As a result of these changes, an increase is seen in cell proliferation and migration, and modulation in Robert Sullivan explores the positive effect that levels of transcription factor.2-5 non-thermal low level lasers can have on the body the These transcription factors then cause through fat cell management protein synthesis that triggers further effects; cytokines, growth factors, inflammatory Non-thermal low-level laser therapy (NTLLLT) has been in clinical mediators, and increased tissue oxygenation.2,3 Again, specific use since the late 1960s,1 and for many years its method of action wavelengths also results in the release of the pro-inflammatory was not fully understood or appreciated. NTLLLT covers a broad cytokine TNF-a from the cells.8 This leads to increased infiltration of medical spectrum which can be used to the benefit of our patients the tissues by leukocytes. NTLLLT also enhances the proliferation, and the expansion of our clinical practice. NTLLLT is also known maturation, and motility of fibroblasts, and increases the production simply as low-level laser, however the term NTLLLT will be used in of basic fibroblast growth factor.9,10 According to Chung et al., this article as not all low-level lasers are non-thermal and some are lymphocytes become activated and proliferate more rapidly and misleadingly labelled as so. Patients are not just looking for ways to epithelial cells become more motile, which allow wound sites aesthetically modify their appearance, but many are also looking for to close more quickly, plus the ability of macrophages to act as ways of restoring, re-energising and revitalising their cells. Current phagocytes is also enhanced under the application of NTLLLT.6 research, as presented in this article, suggests that beauty is no longer skin deep. This short article review demonstrates, in science, that Clinical studies NTLLLT possibly has the ability to restore, rejuvenate, revitalise, and A large number of animal model and clinical studies have re-energise the body, as well as being used for fat cell management. demonstrated highly beneficial NTLLLT effects on a variety of diseases and injuries, and it has been widely used in both chronic How NTLLLT works and acute conditions. NTLLLT may enhance neovascularisation, The biochemical mechanism underlying the therapeutic results of promote angiogenesis and increase collagen synthesis to NTLLLT has a wide range of effects at the molecular, cellular, and promote healing of acute and chronic wounds.11,12 NTLLLT provided tissue levels. There is strong evidence to suggest that within the acceleration of cutaneous wound healing with a biphasic dose cell, NTLLLT acts on the mitochondria via cytochrome-c (COX) to response favouring lower doses.13 It can also stimulate healing of increase adenosine triphosphate (ATP) production. This up-regulates deeper structures such as nerves, tendons, cartilage, bones, and mitochondrial respiration and is the energetic component that even internal organs,14-18 as well as reduce pain, inflammation and 2-5 produces an energy cascade and electron transport. swelling caused by injuries, degenerative diseases or autoimmune Immune cells, in particular, appear to be strongly affected diseases.19-21 There is an exponential increase in the numbers of by NTLLLT. Mast cells play a crucial role in the movement mitochondrial DNA, somatic stem cells and transcription factor as a of leukocytes and are of large importance in inflammation. result of the laser application, all of which decline in age.6,22-24 Specific wavelengths of light can trigger mast cell degranulation, modulation of reactive oxygen species (ROS) and free nitric Body contouring and fat cell management oxide (NO), and the induction of transcription factors. Numerous More recently NTLLLT is being used in body contouring and fat cell transcription factors are regulated by changes in cellular redox management because there is no damage to the fat cell.7 Because state. As described by Chung et al., among them are redox factor-1 fat cells are part of our endocrine system, the release of fat as
Treating the Body with Low Level Lasers
Case study
Before
The patient depicted in Figure 1 undertook a standard plan of nine treatments over 10 weeks (she was asked to maintain her current exercise and nutritional regiment), using a 532 nm non-thermal low-level green laser. It is important to say that this is a true laser, which is one that is collimated, monochromatic and unidirectional. It delivers a 532 nm linear rotating beam through six heads, four of which are moveable to achieve maximum area coverage. The laser was applied 11-15cm
After
Figure 1: A 47-year-old patient before and after eight sessions of NTLLLT treatment
from the skin surface. The heads were distributed to cover the stomach area and thighs, and after 20 minutes the
patient is turned over and the heads repositioned in order to continue the treatment; this is a 40-minute protocol. This was carried out the same way for each session and measurements were taken before and after each session with results filed. The picture shows the condition of the patient at the inception of the treatment. As can be seen, there was well dispersed cellulite deposits, large amounts of fat to the stomach, lateral flanks and mid torso. The after image shows improved skin tone, reduction in cellulite and fat.
Reproduced from Aesthetics | Volume 7/Issue 5 - April 2020
