TargetCool - Introductory Presentation

A new standard of Comfort

TargetCool by CoolHealth

Company Overview

TO PROVIDE NOVEL THERAPY AND ENRICH TREATMENT ALTERNATIVES WITH INNOVATIVE PRECISION COOLING TECHNOLOGY

RecensMedical is a medical-technology company built upon an unprecedented precision tissue cooling technology, which provides novel treatments in the fields of ophthalmology, dermatology, orthopedics and physiotherapy for a safer and more pleasant patient experience. RecensMedical’s portfolio of clinical program includes ocular anesthesia, actinic keratosis, eczema, rosacea, prurigo nodularis, and atopic dermatitis.

Message from CEO

RecensMedical has the world’s top expertise in precision medical cooling which opens more novel treatment opportunities. Our firstof- its-kind ocular cooling anesthesia has demonstrated its unprecedented patient and physician experiences with its superb safety and efficacy. Our multiple clinical programs are elucidating novel therapeutic effects for various unmet-need diseases promising RecensMedical’s pioneer role in precision medical cooling.

CEO Gun-Ho Kim

Our History

202

2

Awarded the USD 5M export tower

Attracted total USD 50M amount in funding

Distributorship in South East Asia, Middle East and Europe.

201 9

OcuCool US phase 1 Clinical trial completed

TargetCool Development of precision cooling treatment device

Acquired GMP certification

Acquired medical device manufacturing license

Acquired ISO 13485 certification

202 1

Establishment US office in Austin, Texas, US

Attracted USD 30M amount in funding

TargetCool Acquired certificate of FDA, CE, KFDA

OcuCool US phase 3 Clinical trial completed

2018

Attracted USD 21M amount in funding

OcuCool Prototype of ophthalmic device

2020

OcuCool US phase 3 Clinical trial started

OcuCool US phase 2 Clinical trial completed

2016

Establishment of corporation

Our Product Regulatory Status

OcuCool

 Ongoing multiple site clinical

 trials in the US

 · FDA approval via de novo

 pathway in process

TargetCool

Cooling on target area with target temp and time

 · KFDA Class II,III medical device  · FDA Class II medical device

 · CE Class II medical device

Our Product Regulatory Status

10 seconds cooling anesthesia for painless intravitreal injection in 1 minute

Intravitreal injection (IVI) is the most common in-office procedure performed by retina specialists to treat various retinal conditions such as age-related macular degeneration (nAMD), diabetic retinopathy (DR) and retinal vein occlusion.

OcuCool

For ophthalmic cooling anesthesia

 Ongoing multiple site clinical

 trials in the US

 · FDA approval via de novo

 pathway in process

Before IVI is performed, anesthesia is applied to minimize injection-related pain and discomfort. Subconjunctival injection, topical anesthesia drops, and gel are commonly used with disadvantages:

· Long onset of anesthesia activation

3-10 mins (Take more than half of total IVI time)

· Physicians to make multiple visits to injection room to treat patients

· Patient’s poor recovery post-injection

· Patient’s anxiety leading to decreased appetite and sleep disorder

Our Product Regulatory Status

TargetCool™ technology is a cutting-edge solution for temperature regulation in various applications.

Precision Cooling

Fine Tuning

TargetCool's technology is versatile and can be used for numerous aesthetic procedures while also being suitable for all ages and skin types.

TargetCool

Cooling on target area with target temp and time

 · KFDA Class II,III medical device

 · FDA Class II medical device

 · CE Class II medical device

Leveraging breakthrough technology, TargetCool represents a leap forward in topical cooling. Compressed CO2 cryogen is modulated by digital controls, IR sensors, and a calibrated nozzle, delivering precise, controlled, rapid cooling to the skin.

Medical Aesthetic Market Now ?

Common Aesthetic

Complications

• Procedure Pain (injection, laser, micro-needling), anatomy dependent

• Substance pain/irritation after the procedure (boosters, fractional, specific meso…etc.)

• External bleeding and internal bleeding (may cause bruising)

• Inflammation (may cause edema & erythema)

Top 5 Concerns Of Aesthetic Patients

TheChina medical aesthetic market maintains a growth rate higher than the steadily growing mature global market

Limited impact of COVID 19 pandemic: The market for China medical aesthetic increased from RMB63.7 billion to MB154.9 billion between 2015 2020, and is projected to exceed RMB350 billion by 2025

Outpacing the global market: Although the growth rate this year will be limited due to the impact of pandemic, we believe that the demand of Chinese consumers is still sufficient and will be gradually released as the pandemic eases, and is expected to maintain a growth rate of more than 10% in the future

*Note: Market size and growth rate shown in the charts above are forecasted based on data as of fourth quarter 2021

Patients' criteria for choosing anti-aging procedure

Doctor ... is it painful?

 How many of your patients didn’t complete the session because of pain?

 How many of your patients didn’t show up for 2nd session because of pain?

 How many times did you reduce your optimal settings because of pain?

 How many times did you waste time waiting for topical anesthesia to work?

 Do we avoid pain by pain (Lidocaine injection)?

Rapid and precision temperature control 01. It

• If the body temperature is reduced instantaneously within a short period of time, the body's blood vessels expand to restore normal body temperature, thereby increasing the supply of oxygen and nutrients in the body. This promotes blood circulation and quickly removes fatigue substances. As a result, it is good for relieving muscle and fatigue, reducing inflammation and helping to heal. In addition, it reduces or blocks the speed

can reduce the pain.

Rapid and precision temperature control

0 No pain

1-3

Mild pain (very noticeable)

4-6

Moderate pain (Distressing to intense, bee sting)

7-9

Severe pain (Dominate senses, ex: migraine)

10

Intolerable/ Worst (Accidents)

01. Rapid and precision temperature control

Pain management by controlled cooling

• Safe prevents complications and damage of tissues

• Stable consistent temperature maintained throughout the treatment

• Standardized repeatable treatment with standardizing treatment protocols

TargetCool : Rapid & Accurate

Others: Slow & Inaccurate

When skin gets cold, it makes less insensitive to pain.

Frostbite temperature

Time (sec)

01. Rapid and precision temperature control

Treatments & Cases

24h after treatment_Lip filler (Juvéderm Ultra XC)

Still do invasive boosting Now ?

Revolutionizing Targeted Drug Delivery with Supersonic CO2 Jet

Real Non-Invasive 02.

A New Paradigm in Skin Drug Delivery System

 Supersonic DEJ delivery for ‘targeted’ penetration

 Non-invasive: No risk of skin infection or damage

 No heat to drug

DEJ- Dermal-Epidermal Junction, is a vital interface that connects lower part of the epidermis to the upper layer of the dermis.

Real Non-Invasive 02.

TargetCool’s

Targeted Drug Delivery with Supersonic CO2 Jet

 The solution is instantly cryo-frozen into microparticles and accelerated close to the speed of sound by a supersonic CO2 jet.

 Ultra high-speed cryo-frozen micro-particles penetrate through the outer layer of the skin (stratum corneum) and then dissolve due to the body heat

 This process allows for the drug to accumulate in extremely high concentrations at the DEJ (dermalepidermal junction) layer.

Proven effect of TargetCool’s skin

Group 3 showed a 215% increase in fluorescence transmission compared to Group 1(untreated control group).

Real Non-Invasive 02.

Proven effect of TargetCool’s skin drug delivery

 The absorption level was significant when using TargetCool boosting mode paired with MTS.

 With single treatment of TargetCool boosting mode shows a relatively high enough absorption level, compared to the ‘Single MTS rolling condition’.

Solution Detection Imaging Results from In Vivo Animal Skin Tissue

 Controlled: Topical application

 MTS treatment: Topical application after MTS rolling

 TargetCool treatment: Application only with TC Boosting mode

 TargetCool treatment: Paired with MTS treatment

MTS+TargretCool

Real Non-Invasive

&

Enhancement in Jawline Lifting

Enhancement in PIH from Acne

Enhancement in Infraorbital dark circles

Comparison Laser or Cryosurgery

Non anesthesia and Non post-operative care 03.

The advantages of using TargetCool

TargetCool is highly effective for removing lesions.

Benign lesions Precancerous lesions Malignant lesions

o Seborrheic Keratosis

o Viral warts

 The TargetCool FDA indication: The FDAapproved indication for The TargetCool™ in its Freezing mode is the surgical destruction of the target tissue by applying CO2 cryogen at extremely low temperatures(-79 ℃).

 TargetCoo will allow quick, effective, noninvasive procedures and requires no anesthesia or no post-operative care. Thus, a wonderful benefit for both providers and patients

o Skin tags

o Solar lentigo

o Melasma

o Freckles

o Genital Lesions

o Skin Tags

o Seborrheic Keratosis

o Lentigo

o Verruca Plana

o Verruca Vulgaris

o Etc.

o Actinic Keratosis

o Bowen’s disease

The only cutaneous malignant lesions that can be offered cryosurgery is the superficial type of basal cell carcinoma in a lowrisk area.

Non anesthesia and Non post-operative care 03.

Comparison Laser vs. Cryosurgery

 Cryosurgery can reduce patient discomfort compared to other surgical methods such as laser treatment and other electrocautery.

02. Rapid and precision temperature control

Treatments & Cases

Before After

Thick lesion, 3 seconds/cm2, 3pass, 2 sessions, every 3 weeks

Before After Thin lesion, 3 seconds/cm2, 2pass, 2 sessions, monthly

Before After Thin lesion, 2 seconds/cm2, 2 sessions

Source : KBSMC 23.03.16

Three. interchangeable modes.

One. revolutionary device.

TargetCool is compatible with three nozzle types configured to spray cryogen at a controlled temperature to the target area.

TargetCool Benefits

Create that elevated patient experience with a device that combats discomfort, unwanted side effects, and increased time.

TargetCool's ability to control the temperature of the skin at the injection point leads to creating a temporary an estheticeffect that leads to a more comfortable injection experience..

Dermal areas treated with TargetCool are much less susceptible to swelling, inflammation, and hematoma. For patients, this means less unsightly bruising after injections and also quicker, easier recoveries.

For patients anxious around needles, TargetCool’s refreshing pain reduction adds peace-ofmind. And TargetCool's ability to rapidly cool the skin also eliminates the wait-time associated with numbing creams.

Testimonials

“The TargetCool device is an easy-to-use system that has quickly become my goto for pain management for various cosmetic procedures. Having the option to minimize post-procedure bruising while increasing patient comfort has elevated the standard of carethat I am able to provide patients.”

Dr. Gary Goldenberg United States, New York

"We have this new device called TargetCool which allows us to do two things at once. lt allows us very quickly to help with the feeling of a negative sensation when we are injecting them with neurotoxins or filler or PRP. It allows my patients to feel much less discomfort, and what we have found in the long run is that it will lead to much less bruising.”

Dr. Mark Nestor United States, Florida. Aventura

""TargetCool's ability to precisely, accurately, and rapidly cool the skin allows providers to determine what cooling time and temperature is optimal for pain reduction, and to consistently use that time and temperature with most patients. There is no guesswork involved.”

Dr Elizabeth Geddes-Bruce United States, Texes, Austin

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