Effec�ve Needle Free Delivery of Topicals Plus, Pain Management and, Lesion removal
All in one revolu�onary device! Introducing:
TargetCool is a breakthrough FDA/CE/ TGA ClassII medical device
Three interchangeable modes. One revolu�onary device. Cooling mode (Temperature Control : -10°C~5°C) · Reduce pain and discomfort
· Minimize inflammation and swelling
Boos�ng mode (Temperature : 2°C ~ 4°C) · Maximizes the absorption of solution into the dermis · Reduce pain and discomfort
Freezing mode (Temperature : -79°C) · Cryosurgery
· Remove lesions
Transforms the liquid substances into an aerosolized state via the high velocity and pressure of the CO 2 cooling. Carboxy therapy from CO 2 promotes faster recovery when paired with substance delivery.
Non-invasive skin booster TargetCool boosting mode offers a non-invasive method to maximize the absorption of solution into the dermis.
TargetCool Boosting Mode components :
Benefit using TargetCool boos�ng mode associated with Micro-Needling (MTS or Needle RF)
Conven�onal Protocols
STEP 1.
STEP 2.
STEP 3.
STEP 4.
MTS Needle RF
Apply exosomes
Massage Solution
LDM
STEP 1.
New Protocol withTargetCool
MTS Needle RF
STEP 2.
TargetCool Boosting Maximizes the absorption of solution
TargetCool boosting mode maximizes absorption of solution, such as exosomes, deep into the dermal layer with simple and effective procedures. CO 2 cooling effect will relieve the burning sensation.
Completion of Procedure
Cooling Therapy • Reduce pain and skin discomfort • Minimize swelling and inflammation • Help control irritationand allergic reactions CO 2 Effect •Antioxidant/ Blood circulation •Acne treatment
Completion of Procedure
Proven effect of TargetCool boos�ng mode The absorption level was more significant when using TargetCool boosting mode paired with MTS.
Exosome detection (In Vivo) using E-50
CTL
MTS
TargetCool
MTS+TargretCool (STEMON, 2022)
Controlled: Topical application MTStreatment: Topical application after MTSrolling TargetCool treatment: Application only with TC Boosting mode TargetCool treatment: Paired with MTStreatment
With single treatment of TargetCool boosting mode shows a significantly higher absorption level when compared, to massaging product in post MTS
Fluorescence Transillumina�on Imaging Results from Ex Vivo Human-Derived Skin Tissue
Proven effect of TargetCool’s skin drug delivery HA Only
The solu�on penetrated into the upper dermis(approx. 0.3m) and the drug con�nues to diffuse into the deep dermis layer and surrounding �ssues.
� Group 2 exhibited the highest level (215% increase )of fluorescence transmission compared to the untreated control group. � Group 3 showed a 165% increase in fluorescence transmission compared to Group 1(untreated control group).
HA + MTS + TargetCool Approx. 0.3mm
Fluorescence Intensity (Value) 500
250%
454 215%
400
381
200
200%
165%
300
150%
HA + TargetCool
100%
144
100
50%
0
0%
HA Only
HA + MTS + TargetCool Value
HA + TargetCool
Increase rate compare to HA Only
� � �
Group 1: Untreated Control Group : HA Only Group 2: HA + TargetCool paired with MTS Group 3: TargetCool only
1 <KINS, 2023>
Synergic effect with CO2 skin permea�on • Reduce inflammation: CO2 Regulates NF-kappa B, which induces the expression of genes that cause inflammation
• Improvement of blood circulation: CO2 induces vasodilation, providing nutrients and oxygen to the skin tissue
• Improving oxygen supply: CO2 lowers blood pH and induces The Bohr effect to supply oxygen to cell tissues
• VEGF induced Formation of blood vessels: increase vascular endothelial growth factor to form new blood vessels and promote blood circualtion
Synergis�c effects of Skin boosters, exosome or PRP when paired with TargetCool • Applying solutionsusing TargetCool Boosting mode after needling enhances the synthesis of collagen and elastic fibres below the DEJ, leading to improved dermal-epidermal adherance, dermal collagen and ECM contents • Skin Microcirculation: The application of CO2 to the skin induces vasodilation, leading to increased blood flow and microcirculation below the DEJ • Uptake and penetration of the solution: CO2 promotes cellular metabolism and enhances the uptake and penetration of the active ingredient
Image of 20MHz Sonogram
��More dense epidermis ��Con�nuous and well-defined, SLEB along the DEJ ��Dense echogenic image in upper dermis
Image 1: Before Treatment
Image 2 : After Treatment
The 20 MHz sonogram image provides a detailed view of the DEJ and its components, the epidermal entrance echo (E), and the Subepidermal low echogenic band (SLEB).
Your Partners in Aesthetic & Regenerative Medicine
Austramedex, also the Australian home to the Revolutionary E-50 exosomes.
To learn more about how Austramedex can help you deliver the best results for your patients, scan the QR code and get in touch.