TargetCool - Topical Delivery System

Effec�ve Needle Free Delivery of Topicals Plus, Pain Management and, Lesion removal

All in one revolu�onary device!

Introducing:

TargetCool is a breakthrough FDA/CE/ TGA ClassII medical device

Three interchangeable modes.

One revolu�onary device.

Cooling mode (Temperature Control : -10°C~5°C) · Reduce pain and discomfort

· Minimize inflammation and swelling

Boos�ng mode (Temperature : 2°C ~ 4°C) · Maximizes the absorption of solution into the dermis · Reduce pain and discomfort

Freezing mode (Temperature : -79°C) · Cryosurgery

· Remove lesions

Transforms the liquid substances into an aerosolized state via the high velocity and pressure of the CO 2 cooling.

Carboxy therapy from CO 2 promotes faster recovery when paired with substance delivery.

Non-invasive skin booster TargetCool boosting mode offers a non-invasive method to maximize the absorption of solution into the dermis.

TargetCool Boosting Mode components :

Benefit using TargetCool boos�ng mode associated with Micro-Needling (MTS or Needle RF)

Conven�onal Protocols

STEP 1.

STEP 2.

STEP 3.

STEP 4.

MTS Needle RF

Apply exosomes

Massage Solution

LDM

STEP 1.

New Protocol withTargetCool

MTS Needle RF

STEP 2.

TargetCool Boosting Maximizes the absorption of solution

TargetCool boosting mode maximizes absorption of solution, such as exosomes, deep into the dermal layer with simple and effective procedures.

CO 2 cooling effect will relieve the burning sensation.

Completion of Procedure

Cooling Therapy • Reduce pain and skin discomfort • Minimize swelling and inflammation • Help control irritationand allergic reactions CO 2 Effect •Antioxidant/ Blood circulation •Acne treatment

Completion of Procedure

Proven effect of TargetCool boos�ng mode The absorption level was more significant when using TargetCool boosting mode paired with MTS.

Exosome detection (In Vivo) using E-50

CTL

MTS

TargetCool

MTS+TargretCool (STEMON, 2022)

Controlled: Topical application MTStreatment: Topical application after MTSrolling TargetCool treatment: Application only with TC Boosting mode TargetCool treatment: Paired with MTStreatment

With single treatment of TargetCool boosting mode shows a significantly higher absorption level when compared, to massaging product in post MTS

Fluorescence Transillumina�on Imaging Results from Ex Vivo Human-Derived Skin Tissue

Proven effect of TargetCool’s skin drug delivery HA Only

The solu�on penetrated into the upper dermis(approx. 0.3m) and the drug con�nues to diffuse into the deep dermis layer and surrounding �ssues.

� Group 2 exhibited the highest level (215% increase )of fluorescence transmission compared to the untreated control group. � Group 3 showed a 165% increase in fluorescence transmission compared to Group 1(untreated control group).

HA + MTS + TargetCool Approx. 0.3mm

Fluorescence Intensity (Value) 500

250%

454 215%

400

381

200

200%

165%

300

150%

HA + TargetCool

100%

144

100

50%

0

0%

HA Only

HA + MTS + TargetCool Value

HA + TargetCool

Increase rate compare to HA Only

� � �

Group 1: Untreated Control Group : HA Only Group 2: HA + TargetCool paired with MTS Group 3: TargetCool only

1 <KINS, 2023>

Synergic effect with CO2 skin permea�on • Reduce inflammation: CO2 Regulates NF-kappa B, which induces the expression of genes that cause inflammation

• Improvement of blood circulation: CO2 induces vasodilation, providing nutrients and oxygen to the skin tissue

• Improving oxygen supply: CO2 lowers blood pH and induces The Bohr effect to supply oxygen to cell tissues

• VEGF induced Formation of blood vessels: increase vascular endothelial growth factor to form new blood vessels and promote blood circualtion

Synergis�c effects of Skin boosters, exosome or PRP when paired with TargetCool • Applying solutionsusing TargetCool Boosting mode after needling enhances the synthesis of collagen and elastic fibres below the DEJ, leading to improved dermal-epidermal adherance, dermal collagen and ECM contents • Skin Microcirculation: The application of CO2 to the skin induces vasodilation, leading to increased blood flow and microcirculation below the DEJ • Uptake and penetration of the solution: CO2 promotes cellular metabolism and enhances the uptake and penetration of the active ingredient

Image of 20MHz Sonogram

��More dense epidermis ��Con�nuous and well-defined, SLEB along the DEJ ��Dense echogenic image in upper dermis

Image 1: Before Treatment

Image 2 : After Treatment

The 20 MHz sonogram image provides a detailed view of the DEJ and its components, the epidermal entrance echo (E), and the Subepidermal low echogenic band (SLEB).

Your Partners in Aesthetic & Regenerative Medicine

Austramedex, also the Australian home to the Revolutionary E-50 exosomes.

To learn more about how Austramedex can help you deliver the best results for your patients, scan the QR code and get in touch.