SPONSORSHIP AVAILABLE FOR THE POST-DOCTORAL POSITION Our Lab would like to sponsor positions for the deserving Post Doctorate Fellows (Research Associate) who wish to apply in my lab. With me as a mentor, the project will be written by the candidate, assisted by me, for applying to the fellowships like DBT-RA, NPDF, WOS, UGCRA, ICMR-RA, INSA/. If and when the project is granted, I will be happy to accommodate the candidate in my Lab and extend all the facilities and knowledge in the fields of Molecular Biology, Protein Chemistry and Virology. Our Lab works on following four projects: 1. Development of in vitro HEV Culture system to establish the role of its enzymes and their inhibitors to study the replication cycle of the virus. (DST) 2. Biochemical and Biophysical characterization of the non-structural enzymes of HEV involving their crystallization to find out their inhibitors that may act as putative drug candidates. (DBT) 3. Study the mechanism of processing of HEV polyprotein leading to its cleavage into Nonstructural enzymes. (DST) 4. Modelling and simulation of the non-structural enzymes to predict the active site and its inhibitors using virtual screening ( WOSA) 5. Finding out cleavage sites on HEV polyprotein by mutagenizing Cysteine protease, the digesting enzyme, Desirable: Person desirous of getting sponsored and working with us should be well versed with techniques in the fields of Biochemistry /Recombinant DNA Technology/Virology as evident from their publications. Please send your CV and Research statement to deepak.sehgal@snu.edu.in If found suitable, I will get in touch subsequently for further discussion
Our 2020 publication: Published: Hepatitis E Virus Cysteine Protease has Papain like Properties Validated by insilico Modelling and Cell-free Inhibition Assays Shweta Saraswat1, Meenakshi Chaudhary1, Deepak Sehgal1* Frontiers in cellular and infection microbiology Communicated 2020: Development of BacMam Induced Hepatitis E Virus Replication Model in Hepatoma Cells to Study the Polyprotein Processing. Viruses: Manjeet Kumar1,Âś, Preeti Hooda1,Âś Madhu Khanna2, Utkarsh Patel1 and Deepak Sehgal1,* Communicated 2020 Insights in E64 induced structural changes in Hepatitis E virus protease Meenakshi Chaudhry and Deepak Sehgal