What is Galantamine Hydrobromide used for?

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What is Galantamine Hydrobromide used for?

With all the clinical trials done on this nootropic, it is evident that Galantamine Hydrobromide powder (1953-04-4) could help you in very many ways. Here are ways on how it could improve your health; 

It is an antioxidant

When the body suffers from oxidative stress, there could be more health issues coming up, e.g., diabetes, cancer, Down’s syndrome, Huntington’s, Parkinson’s, and Alzheimer’s disease. Luckily, Galantamine Hydrobromide acts as an antioxidant by protecting the cells from oxidative cells.

It also protects the human brain from neuronal damage caused by reactive oxygen species (ROS). It does this through the activation of NRF2 and by protecting the mitochondria. 

It offers protection against toxins

We always hear about air pollution and toxins in the drinks and food that we consume. Such contaminants affect the way our body function and could even lead to illnesses. As much as our body has some in-born protection, it is never enough. No wonder nature has gifted us with 1/7

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the Galantamine nootropic to give protection against toxic chemicals and elements.

In a study done on rats, Galantamine supplement showed that it could protect against the effects brought about by toxic poisoning caused by diisopropylfluorophosphate.

It also proved that it could filter out endotoxins from the rat’s blood by lowering the pro-inflammatory cytokine levels as well as reducing the MPO activity. 

May help in the treatment of diabetes

One way of fighting diabetes is by improving insulin signaling pathways, i.e., GLUT2 and GLUT4 receptors, p-Akt, p-insulin.

In mice suffering from type-1 diabetes, Galantamine Hydrobromide reduced the immune cell action, delayed high blood sugar, and reduced the production of anti-insulin antibodies.

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It aids in the treatment of obesity

Obesity is one of the conditions that a third of the world’s population is suffering from. Taking Galantamine Hydrobromide is one of the effective ways that you could counter obesity.

When administered to rodents with high fat diet-induced obesity, it was observed that it helped lower insulin resistance, cholesterol levels, body weight as well as inflammation. 

It reduces inflammation 3/7

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There are very many influences that contribute to the body experiencing inflammation. Whether it is tissue damage, infections, diet or germs, Galantamine Hydrobromide (1953-04-4) is one of the effective ways you could reverse it. It does this through the modification of adiponectin, visfatin, NF-κB, and TNF-α. Also, Galantamine Hydrobromide decreases brain inflammation.

Other than that, Galantamine Hydrobromide also works through the activation of the cholinergic anti-inflammatory pathway, which is one of the vital anti-inflammatory pathways whose function is to guard the body against prolonged exposure to systemic inflammation. The cholinergic anti-inflammatory pathway is activated by the α7 nicotinic acetylcholine receptors (α7 nAChR).

This activation that is brought about by Galantamine Hydrobromide could also help reduce the pro-inflammatory production of cytokine by a range of fifty to seventy-five percentages.

Additionally, Galantamine Hydrobromide suppresses systemic inflammation by reducing the breakdown of acetylcholine by inhibiting acetylcholinesterase. 

Improves cognitive function

You have probably heard of if not suffered from mild cognitive impairment (MCI). It is a stage whereby one undergoes a decline in one’s cognitive performance. Often, it leads to problems with language, memory, judgment, and thinking which are not as a result of healthy aging.

If you are suffering from this, then you may experience changes in your daily life as well as your usual activities. Fortunately, research done on Galantamine Hydrobromide confirms that at a Galantamine dosage of 4mg twice a day, it could help in increasing one’s performance in memory tasks. That includes working memory tasks and episodic face encoding.

Another study done on the same demonstrated that this nootropic supplement assisted patients with mild cognitive impairment by reducing reaction times and improving episodic memory.

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What makes Galantamine very effective in improving one’s brain function is because it is a nicotinic acetylcholine receptors modulator and an acetylcholinesterase inhibitor. That makes it able to counter-memory impairment in MCI subjects which could be as a result of the cholinergic malfunction.

Also, Galantamine enhances brain growth by activating the α7 nicotinic acetylcholine and M1 muscarinic receptors. In rats, administration with Galantamine led to an increase in brain IGF-2 levels at 0.3-3mg/kg. That indicates that this nootropic could increase the growth of a new brain.

Another Galantamine use is in the treatment of dementia which could be caused by Alzheimer’s disease and vascular dementia. If used during the early stage and continued for at least a year, it could help counter the loss of remembering, thinking, and reasoning skills.

If used for at least three years, it helps in limiting the cognitive decline caused by Alzheimer’s disease. It also increases the connectivity between neurons in the brains of Alzheimer’s patients. That contributes to the stabilization of cognitive performance. All these suggest that there is a long term potential in using Galantamine.

By increasing the action and concentration of acetylcholine in the brain, Galantamine is beneficial in relieving some of the Alzheimer’s disease symptoms. One of the signs is the decrease in hippocampal episodic memory function caused by the β-amyloid plaques builds up, thus leading to the breakdown of cholinergic signaling.

As an Alzheimer’s disease treatment, Galantamine increases the hippocampal function (part of the brain that aids in memory and learning) by improving the cholinergic neurotransmitter function.

Galantamine could also help in reducing the amount of beta-amyloid plaques and decrease the action of astrocytes. Dementia patients could also benefit from the antidepressant effects and the quality sleep that this supplement gives.

In matters of effectiveness, Galantamine is as potent as donepezil, a cognition enhancer used in the treatment of Alzheimer’s disease.

However, Galantamine is much more cost-friendly compared to other Alzheimer’s disease medications. That makes it a good option for those who want an effective and affordable drug for the treatment of this condition.

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Induces lucid dreaming

Each one of us has had a lucid dream; it is a dream whereby you are aware that you are dreaming and maybe have some control over it.

Galantamine enhances this through the alteration of the cholinergic system and the increase of acetylcholine levels in the brain. 

May reduce symptoms of autism

When Galantamine was administered alongside Risperidone to autistic children, it was observed that it improved autism symptoms, including social withdrawal, lethargy, and irritability.

It also enhances expressive language and communication in adults with autism through the stimulation of the serotonergic subsystem situated in the central nervous system (CNS). 

May aid in the treatment of schizophrenia

Increased levels of kynurenic acid are to blame for the cognitive problems associated with schizophrenia. Galantamine works by neutralizing the damaging effects caused by high kynurenic acid levels. It also improves the AMPA-mediated signaling pathway, thus protecting the brain and enhancing schizophrenics’ memory. 

Helps reduce smoking addiction

Quitting smoking is one of the problematic things smokers undergo due to the addiction it causes. One weapon that has in the past helped people beat this type of addiction is the use of Galantamine Hydrobromide powder (1953-04-4).

Smokers who were administered with Galantamine daily reported that they smoked on fewer days and their total cigarettes reduced in number compared to those that were on a placebo. That proved to be a powerful way of fighting addiction as it reduced it without combining it with any other initiatives.

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Relieves arthritis

A study done on rats with low testosterone attested that Galantamine suppresses arthritic inflammation. During Galantamine treatment, there is the appearance of dopamine in the spleen; hence substantiating claims that it provides protective action under androgen-deficient conditions. 

Protects against brain trauma

Psychotic patients who are not responding to drugs undergo electroconvulsive therapy (ECT). This treatment, however, leads to cognitive impairment which could affect one’s quality of life. In the past, using the Galantamine supplement has helped protect against the loss of learning abilities when administered during and after treatment with ECT.

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