Sulforaphane Bulk Powder (142825-10-3)

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Sulforaphane Bulk Powder (142825-10-3) 01

Overview

Sulforaphane powder is a cruciferous vegetable-derived isothiocyanate with promising antitumor, chemopreventive and therapeutic activities, it inhibits TPA-induced NF-κB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKα and NAK-IKKβ.

Sulforaphane powder may exert a significant neuroprotective effect on cholinergic deficit and cognitive impairment, it also has anti-inflammatory effect, at least ,in part,associated with interfering with the NF-κB pathway.

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Sulforaphane Powder (142825-10-3) video

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Sulforaphane Powder Base Information

Name

Sulforaphane Powder

CAS

142825-10-3

Purity

0.1-98%

Chemical name

D,L-Sulforaphane

Synonyms

sulforafan; sulforaphan; sulforaphane; R-SULFORAPHANE; R,S-SULFORAPHANE; SULFORAPHANE, L-; SULFORAPHANE, DL-; SULFORAPHANE, D-

Molecular Formula

C6H11NOS2

Molecular Weight

177.3

Melting Point

68.93° C (Predicted)

InChI Key

SUVMJBTUFCVSAD-UHFFFAOYSA-N

Form

Powder

Appearance

Colourless to Yellow

Half Life

/

Solubility

Chloroform (Sparingly), Methanol (Slightly)

Storage Condition

−20°C

Application

Potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Occurs naturally in broccoli.

It was found to inhibit chemically induced mammary tumor 1/5

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formation in rats. Antitumor agent.

Sulforaphane is reported to a small study to alleviate the symptoms associated with autism.

Testing Document

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Available

Sulforaphane Powder General Description

Sulforaphane, that is isolated from the seeds of Brassica oleracea L. var. botrytis L, is a cruciferous vegetable-derived isothiocyanate with promising chemopreventive and therapeutic activities. Sulforaphane powder has antitumor effects against bladder cancer cells through an ROS-mediated intrinsic apoptotic pathway, and suggest that ER stress and Nrf2 may represent strategic targets for Sulforaphane-induced apoptosis. Sulforaphane might exert a significant neuroprotective effect on cholinergic deficit and cognitive impairment. Broccoli sprouts contain large amounts 2/5

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of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale.

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Sulforaphane Powder (142825-10-3) History

Sulforaphane powder is an isothiocyanate present naturally in widely consumed vegetables; has shown anticancer and cardioprotective activities.

In Vitro:Sulforaphane induces a cell cycle arrest in a dose-dependent manner, followed by cell death. This sulforaphane-induced cell cycle arrest was correlated with an increased expression of cyclins A and B1. Sulforaphane induces cell death via an apoptotic process. Sulforaphane inhibits the reinitiation of growth and diminishes cellular viability in quiescent colon carcinoma cells (HT29) and has a lower toxicity on differentiated CaCo2 cells. Pre-treatment of H9c2 rat myoblasts with sulforaphane decreases the apoptotic cell number and the expression of pro-apoptotic proteins (Bax, caspase-3 and cytochrome c), as well as the doxorubicin-induced increase in mitochondrial membrane potential. Furthermore, sulforaphane increases the mRNA and protein expression of heme oxygenase-1, which consequently reduces the levels of reactive oxygen species (ROS, measured using MitoSOX Red reagent) in the mitochondria which are induced by doxorubicin.

In Vivo:Sulforaphane can block the formation of ammary tumors in Sprague-Dawley rats treated with single doses of 9,10-dimethyl-1,2-benzanthracene. Administration of sulforaphane reduces the incidence, multiplicity, and weights and delays the development of the mammary tumors evoked by a single dose of DMBA in female Sprague-Dawley rats.

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Sulforaphane Powder Mechanism Of Action

Biochem/physiol Actions Selective inducer of phase II detoxification enzymes with anticarcinogenic properties.

Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-ι.

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Sulforaphane Powder (142825-10-3) Application 3/5

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Sulforaphane can prevent skin cancer when applied directly to the skin.

Sulforaphane is a Potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Occurs naturally in broccoli. It was found to inhibit chemically induced mammary tumor formation in rats. Antitumor agent.

Sulforaphane is reported to a small study to alleviate the symptoms associated with autism.

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Sulforaphane Powder (142825-10-3) More

research Sulforaphane exhibits anticancer, antidiabetic, and antimicrobial properties in experimental models. It is obtained from cruciferous vegetables such as broccoli, Brussels sprouts or cabbages. The enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing).

Young sprouts of broccoli and cauliflower are particularly rich in glucoraphanin.

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Sulforaphane Powder (142825-10-3) Document

Download COA

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Sulforaphane Powder (142825-10-3) Reference Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.

J Pharmacol Exp Ther.

2018 Mar;364(3):377-389. doi: 10.1124/jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.

Zhang, Y., et al.: Proc. Natl. Acad. Sci. USA, 89, 2399 (1992), Shikita, M., et al.: Biochem. J., 341, 725 (1999), Wittich, S., et al.: J. Med. Chem., 45, 3296 (2002), Lee, J., et al.: Cancer Lett., 224, 171 (2005); Chem. and Eng. News, p 11, Oct. 20 (2014) Gamet-Payrastre L, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 2000 Mar 1;60(5):1426-33.

Li B, et al. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int J Mol Med. 2015 Jul;36(1):53-64. [3]. Zhang Y, et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornylisothiocyanates.

Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50.

2020 Glucoraphanin Vs. Sulforaphane: The Best Antioxidant and Key Nutrient In Broccoli

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PRECAUTION AND DISCLAIMER: This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

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