Nigella Sativa Seeds Extract (490-91-5)

www.wisepowder.com

wise12@wisepowder.com

Nigella Sativa Seeds Extract (490-91-5) 01

Overview

Nigella sativa seeds extract as one of the most amazing and unique herbal extract, helps lower blood pressure, anti-inflammatory, anti-bacterial, anti-viral, anti-fungal, anti-ulcer and anti-cancer, but also can protect the kidneys, increase insulin sensitivity.

02

Contact Us 1/5

www.wisepowder.com

wise12@wisepowder.com

No. 668, Xiangyin Road, Yangpu District, 200433, Shanghai, China +86 （1392）6572370 09:00 – 18:00 weekdays info@wisepowder.com

03

Nigella Sativa Seeds (490-91-5) video

04

Nigella Sativa Seeds Base Information

Name

Nigella Sativa Seeds Extract

CAS

490-91-5

Purity

Thymoquinone: 5%,10%,98%

Chemical name

THYMOQUINONE

Synonyms

NSC 2228;Thymoquinon;THYMOQUINONE; thymolquinone; Semen Nigellae; AURORA KA-6714; Nigellae Semen; Thymoquinone,99%; Black seed extract; p-Cymene-2,5-dione

Molecular Formula

C10H12O2

Molecular Weight

164.204

Melting Point

45-47 °C(lit.)

InChI Key

KEQHJBNSCLWCAE-UHFFFAOYSA-N

Form

Solid

Appearance

Yellow Brown to Brown Powder

Half Life

/

Solubility

solubility in water, and good biological activity

Storage Condition

Store in Cool & Dry Places.Please Keep Away From Strong Light

Application

Anti-aging, Anti-fatigue, Anti-inflammatory

Testing Document

Available

05

Nigella Sativa Seeds Extract 490-91-5 General

Description 2/5

www.wisepowder.com

wise12@wisepowder.com

Black cumin seeds are native to southwest Asia. They are commonly used for culinary purposes in candy making and preparation of liquors due to their pungent bitter smell and taste. Black cumin seeds have been used for centuries for medical purposes. A study in the August 2000 “Phytotherapy Research” confirms the presence of chemicals in black cumin seeds that offer antioxidant benefits, primarily the chemical thymoquinone. Antioxidants rid the body of free radicals that cause cell damage and promote disease. Consumption of black cumin seeds is considered an herbal, alternative treatment and should be taken under the direction of a physician

06

Nigella Sativa Seeds Extract 490-91-5 History

Nigella sativa seeds extract is mentioned in an Old Testament, that Black Seed can cure every sickness except death.

Nigella sativa seeds, also named black cumin seeds or black seeds, have been used to make medicine for over 2000 years.

The FDA approved Black Seed several years ago.

07

Nigella Sativa Seeds Extract 490-91-5 Mechanism

Of Action The Mechanism Of Action of Nigella Sativa Seeds Extract is unsure now, it has the Health Benefit, such as Anti-cancer ， cholesterol levels Control, Anti-fatigue, Anti-inflammatory, etc.

08

Nigella Sativa Seeds Extract 490-91-5 Application

Thymoquinone is a phytochemical compound found in the plant Nigella sativa.

Thymoquinone has antioxidant effects and has been shown to protect against heart, liver and kidney damage in animal studies, as well as having possible anti-cancer effects. Thymoquinone also has analgesic and anticonvulsant effects in animal models. Thymoquinone is an angiogenesis inhibitor.

09

Nigella Sativa Seeds Extract 490-91-5 More

research Anticancer Research 3/5

www.wisepowder.com

wise12@wisepowder.com

The black cumin (Nigella sativa) that has a long history of medicinal use contains aphytochemical called thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone)(Padhye et al. 2008; Khan et al. 2011). In the regions of Southeastern Asia, Africa,Arab and the Mediterranean, the black cumin seeds have a notable history in traditionalmedicine practices. In ancient Egypt, Greece and Turkey, black cumin seedswere often used to treat many diseases and ailments (Padhye et al. 2008; Salih et al.2009; Khan et al. 2011; Ahmad et al. 2013).

The Nigella sativa plant seeds and oilare used for medicinal purposes, and they are known for their hepatoprotective,renal-protective, antimicrobial, antidiabetic, anticancer, antihypertensive, analgesic,anti-inflammatory, immunomodulatory, spasmolytic, gastro-protective, bronchodilativeand antioxidant activities (Salih et al.

2009; Khan et al. 2011; Ahmad et al.2013). Recently, Barkat et al. (2017) reported that administration of thymoquinoneto MDA-MB-231 acts on cell cycle and inhibits progression from G1 to S phase bytargeting the cell cycle-related proteins such as cyclin D1, cyclin E and p27. It alsoexhibits histone deacetylase (HDAC) inhibitory effects, targets p21 and Maspin andinduces pro-apoptotic gene, Bax, and downregulates anti-apoptotic gene Bcl-2(Barkat et al. 2017).

Thymoquinone is the primary bioactive constituent of seed oil of Nigella sativa. It is a chemopreventiveagent and suppresses the proliferation of breast, colorectal, leukemia, osteosarcoma,ovarian, and pancreatic cancer cells. It suppresses TNF-inducedactivationof NF-κB in a time- and dose-dependent manner and the subsequent inhibition ofIκBα kinase activation, IκBα degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It specifically suppresses the nuclear p65 and recombinantp65 direct binding to DNA. It also downregulates the expression ofNF-κB-regulated antiapoptotic (survivin, IAP1, Bcl-xL, XIAP IAP2, Bcl-2), proliferative(cyclin D1, c-myc, and COX-2), and angiogenic (VEGF and MMP-9) geneproducts. It suppresses the activation of ERK and AKT pathways and blocks in vitroand in vivo angiogenesis (Aggarwal et al. 2008).

10

Nigella Sativa Seeds Document Download

COA

11

Nigella Sativa Seeds Extract 490-91-5 Reference

[1] Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line.

Khurshid Y, Syed B, Simjee SU, Beg O, Ahmed A. BMC Complement Med Ther. 2020 Jan 13;20(1):5. doi: 10.1186/s12906-019-2804-1.

4/5

www.wisepowder.com

wise12@wisepowder.com

[2] Antifungal potency of Nigella sativa seeds extract against Rhizopus stolonifer and their effect of immunomodulatory against aflatoxin-fed mice.

Othman GA, Alghamdi HA, Ahmed DAEM, Radwan AM. Pak J Pharm Sci. 2019 Jul;32(4(Supplementary)):1849-1854.

[3] AgNPs from Nigella sativa Control Breast Cancer: An In Vitro Study.

Rohini B, Akther T, Waseem M, Khan J, Kashif M, Hemalatha S. J Environ Pathol Toxicol Oncol. 2019;38(2):185-194. doi: 10.1615/JEnvironPatholToxicolOncol.2019027318.

12

PRECAUTION AND DISCLAIMER:

PRECAUTION AND DISCLAIMER: This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

5/5