Nicotinamide Riboside Chloride powder (23111-00-4)

www.wisepowder.com

wise12@wisepowder.com

Nicotinamide Riboside Chloride powder (23111-00-4) 01

Overview

Nicotinamide Riboside Chloride powder, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. NR blocks degeneration of surgically severed dorsal root ganglion neurons ex vivo and protects against noise-induced hearing loss in living mice. Nicotinamide riboside prevents muscle, neural and melanocyte stem cell senescence. Increased muscular regeneration in mice has been observed after treatment with nicotinamide riboside, leading to speculation that it might improve regeneration of organs such as the liver, kidney, and heart. Nicotinamide riboside also lowers blood glucose and fatty liver in prediabetic and type 2 diabetic models while preventing the development of diabetic peripheral neuropathy. Note: Nicotinamide Riboside chloride is a ι/β mixture

1/6

www.wisepowder.com

02

wise12@wisepowder.com

Nicotinamide Riboside Chloride powder

(23111-00-4) video 03

Nicotinamide Riboside Chloride (23111-00-4) Base

Information Name

Nicotinamide Riboside Chloride powder

CAS

23111-00-4

Purity

98%

Chemical name

3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tet rahydrofuran-2-yl)pyridin-1-ium chloride

Synonyms

Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, α/β mixture

Molecular Formula

C11H15ClN2O5

Molecular Weight

290.7 g/mol

Melting Point

115℃-125℃

InChI Key

YABIFCKURFRPPO-FSDYPCQHSA-N

Form

Solid

Appearance

Off White to Pale Yellow powder

Half Life

2.7 hours

Solubility

Soluble in DMSO

Storage Condition

Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

Application

Nicotinamide riboside is a pyridine-nucleoside form of vitamin B3 .Its Nootropics

Testing Document

Available

04

Nicotinamide Riboside Chloride (23111-00-4)

General Description Nicotinamide Riboside Chloride powder nucleosides are precursors of nicotinamide adenine dinucleotide (NAD) and represent a source of vitamin B3. Recent studies have shown that taking in a greater amount of nicotinamide nucleosides naturally present in foods can provide new health benefits. For example, nicotinamide nucleosides have been implicated in increasing tissue NAD concentration and 2/6

www.wisepowder.com

wise12@wisepowder.com

inducing insulin sensitivity as well as enhancing sirtuin function. Its ability to increase NAD production suggests that nicotinamide nucleosides can also improve mitochondrial health, stimulate mitochondrial function, and induce the production of new mitochondria. Other studies using nicotinamide nucleosides in the Alzheimer’s disease model have shown that the molecule is bioavailable to the brain and may provide neuroprotection by stimulating brain NAD synthesis..

05

Nicotinamide Riboside Chloride(23111-00-4)

History At the 2012 study observed that mice fed a high-fat diet supplemented with nicotinamide nucleosides had a 60% reduction in weight gain compared to mice fed the same high-fat diet without nicotinamide nucleoside.

As an anthracycline antibiotic, doxorubicin is one of the most effective and widely used chemotherapeutic drugs in the treatment of various types of solid tumors.

Unfortunately, for decades, its cardiotoxicity in the treatment of cancer has limited the drug’s Clinical use.

06

Nicotinamide Riboside Chloride (23111-00-4)

Mechanism Of Action Nicotinamide Riboside (NR) is a recently discovered form of vitamin B3 that can increase levels of Nicotinamide Adenine Dinucleotide (NAD+) levels in humans.

NAD+ is a key co-enzyme that the mitochondria in every cell of our bodies depend on to fuel all basic functions.

NAD+ levels drop as we age and when our bodies are stressed by disease or chronic inflammation.

Niacinamide is a component of coenzyme I and coenzyme II, becoming the coenzyme of many dehydrogenases.

In food processing, nicotinamide is used together with Vc as a color former Niacin is also called vitamin B3, or vitamin PP,Niacin is also known as nicotinic acid and niacin. The human body also includes its derivative nicotinamide or nicotinamide.

It is one of the 13 vitamins necessary for human body, is a water-soluble vitamin, belongs to the B family of vitamin B. Nicotinic acid in converted into niacinamide, nicotinamide coenzyme and part of coenzyme , participates in the metabolism of 3/6

www.wisepowder.com

wise12@wisepowder.com

lipids and tissue respiration of oxidation process and the process of anaerobic decomposition sugar.

07

Nicotinamide Riboside Chloride (23111-00-4)

Application Preclinical studies have shown that the addition of nicotinamide ribose can not only increase NAD+ levels safely, but also maximize the utilization of NAD+ in humans, which is not possible with other vitamin B3.Studies have shown that once nicotinamide ribose appears in the cell, the body rapidly transforms it into NAD+.

These NAD+ then stimulate the process of intracellular initiation of energy production by mitochondria Nicotinamide Riboside Chloride can enhance mitochondrial function, which is shown to enhance the expression of mitochondrial electron transport chain proteins, enhance mitochondrial membrane potential, and increase the rate of oxidative respiration and intracellular ATP levels. This may be accompanied by higher levels of mitochondrial regeneration. Mitochondrial function declines as we age, and this is the sign of the aging of stem cells that we find. NR can enhance the function of mitochondria and inhibit the senescence of stem cells.

08

Nicotinamide Riboside Chloride (23111-00-4)

More research Nicotinamide nucleosides are precursors of nicotinamide adenine dinucleotide (NAD) and represent a source of vitamin B3. Recent studies have shown that taking in a greater amount of nicotinamide nucleosides naturally present in foods can provide new health benefits. For example, nicotinamide nucleosides have been implicated in increasing tissue NAD concentration and inducing insulin sensitivity as well as enhancing sirtuin function. Its ability to increase NAD production suggests that nicotinamide nucleosides can also improve mitochondrial health, stimulate mitochondrial function, and induce the production of new mitochondria. Other studies using nicotinamide nucleosides in the Alzheimer’s disease model have shown that the molecule is bioavailable to the brain and may provide neuroprotection by stimulating brain NAD synthesis.

Nicotinamide Riboside Chloride also can Reduce weight: Studies have shown that by increasing energy metabolism, you can effectively reduce the high-fat diet induced weight gain. In order to evaluate the nicotinamide ribose mechanism of NR promoting weight loss, the researchers measured the liver mitochondrial function 4/6

www.wisepowder.com

wise12@wisepowder.com

associated with caloric intake, activity, calories, waist circumference, resting metabolic rate, body composition, glucose tolerance, insulin sensitivity and various biochemical and metabolomics parameters. These data and the new weight loss mechanism by malabsorption, excretion of biological markers for tracking. The researchers reported that mice fed nicotinamide nicotinamide supplements were significantly more likely to lose weight relative to mice that did not supplement nicotinamide

09

Nicotinamide Riboside Chloride (23111-00-4)

Document Download COA

10

Nicotinamide Riboside Chloride (23111-00-4)

Reference 

Chi Y, Sauve AA. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care.

2013 Nov;16(6):657-61. doi: 10.1097/MCO.0b013e32836510c0. Review. PubMed PMID: 24071780.



Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr.

2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443. Review. PubMed PMID: 18429699.



Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):561-74. doi: 10.3109/10409238.2013.838204. Review. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.



Yang Y, Sauve AA. NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy.

Biochim Biophys Acta.

2016 Dec;1864(12):1787-1800. doi: 10.1016/j.bbapap.2016.06.014. Review. PubMed PMID: 27374990.



Best Nootropic Stack Guide: Everything You Need To Know [5 Years Experience] Everything You Need to Know About Nicotinamide Riboside Chloride



5/6

www.wisepowder.com

wise12@wisepowder.com

PRECAUTION AND DISCLAIMER: This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

6/6