High Purity beta carboline powder (244-63-3) from Wisepowder

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High Purity beta carboline powder (244-63-3) from Wisepowder Overview Norharmane acts powder as a co-mutagen. Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family. It is a heterocyclic amine (HCA) that may also be found in fried meats, tobacco smoke, and coffee. Harman and norharmane are aminocarbolines known as “co-mutagens” because they do not show mutagenicity to Salmonella serovar typhimurium.

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beta carboline powder (244-63-3) video beta carboline powder Base Information Name

beta carboline powder

CAS

244-63-3

Purity

98%

Chemical name

9H-pyrido[3,4-b]indole

Synonyms

Norharmane; β-Carboline; 2-Azacarbazole.

Molecular Formula

C11H8N2

Molecular Weight

168.2 g/mol

Melting Point

200.0 to 203.0 deg-C

InChI Key

AIFRHYZBTHREPW-UHFFFAOYSA-N

Form

Solid

Appearance

light yellow

Half Life Solubility

Soluble in DMSO, not in water

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Application

The compund has cytotoxic effects.

Testing Document

Available

beta carboline powder General Description Norharmane powder is a β-Carboline alkaloid that is widespread in plants and animals, and frequently act as benzodiazepine inverse agonists. Norharmane showed a potent inhibition against α-glucosidase enzyme in a concentration dependent manner with an IC50 value of 0.27 mM for maltase and 0.41 mM for sucrase, respectively. A Lineweaver-Burk plot revealed that norharman inhibited α-glucosidase enzyme uncompetitively, with a Ki value of 0.13 mM.

beta carboline powder (244-63-3) History Norharmane powder is an inhibitor of indoleamine 2,3-dioxygenase. Norharmane is a heterocylce that can be used as a matrix for analysis cyclodextrins. Has cytotoxic effects.also known as norharmane, is a nitrogen containing heterocycle. It is also the prototype of a class of compounds known as β-carbolines.

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Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family. It is a heterocyclic amine that may also be found in fried meats, tobacco smoke, and coffee.1,2 While not mutagenic by itself, norharmane is described as a co-mutagen, as it induces or enhances the mutagenicity of other compounds, commonly forming DNA adducts.

beta carboline (244-63-3) Mechanism Of Action A natural β-carboline that may be found in fried meats, cigarette smoke, and coffee; described as a co-mutagen, as it induces or enhances the mutagenicity of other compounds Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family. It is a heterocyclic amine that may also be found in fried meats, tobacco smoke, and coffee. While not mutagenic by itself, norharmane is described as a co-mutagen, as it induces or enhances the mutagenicity of other compounds, commonly forming DNA adducts.

beta carboline (244-63-3) Application Beta-carboline is the parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring. It has a role as a marine metabolite and a fungal metabolite. It is a member of beta-carbolines and a mancude organic heterotricyclic parent.

Harman and norharmane with concentrations of 0.275 uM and 0.9 uM respectively might inhibited MAO-A and MAO-B. In adult male rats, a novel cocktail of cigarette smoke constituents, containing five minor alkaloids (nornicotine, cotinine, myosmine, anatabine, and anabasine), two β-carbolines (harman and norharmane), and acetaldehyde, did not significantly enhance nicotine self-administration.

beta carboline (244-63-3) More research Norharmane matrix enhances detection of endotoxin ， by MALDI-MS for simultaneous profiling of pathogen,for host–pathogen interaction studies by mass spectrometry imaging; we emphasize the improved detection of pathogen-specific lipids (endotoxin) achievable only with norharmane (NRM), an underutilized matrix substance facilitating，The discovery of novel pathogenic mechanisms engaged during bacterial infections requires the evolution of advanced 3/5

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techniques. Here, we evaluate the dual polarity matrix norharmane (NRM) to improve detection of bacterial lipid A (endotoxin), from host and vector tissues infected with Francisella novicida (Fn).

beta carboline (244-63-3) Document Download COA

beta carboline (244-63-3) Reference 1: Wojtowicz E, Zawirska-Wojtasiak R, Przygoński K, Mildner-Szkudlarz S. Bioactive β-carbolines norharman and harman in traditional and novel raw materials for chicory coffee.

Food Chem.

2015 May 15;175:280-3. doi: 10.1016/j.foodchem.2014.11.143. Epub 2014 Nov 29. PubMed PMID: 25577081.

2: Wabaidur SM, Lee SH, Alothman ZA, Siddiqui MR, Alam SM. Second derivative synchronous fluorimetric method for simultaneous determination of harman and norharman in coffee samples. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Jun;110:179-84. doi: 10.1016/j.saa.2013.03.045. Epub 2013 Mar 16. PubMed PMID: 23563636.

3: Esmaeili MH, Movahedi M, Faraji A, Haghdoost-Yazdi H. Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat. Neurotoxicol Teratol. 2012 Sep-Oct;34(5):489-94. doi: 10.1016/j.ntt.2012.07.001. Epub 2012 Jul 9. PubMed PMID: 22789434.

4: Tan C, Wu S, Lai S, Wang M, Chen Y, Zhou L, Zhu Y, Lian W, Peng W, Ji L, Xu A. Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes. Dalton Trans. 2011 Sep 14;40(34):8611-21. doi: 10.1039/c1dt10084j. Epub 2011 Jul 29. PubMed PMID: 21804968.

5: Thatcher RJ, Douthwaite RE. β-Carboline (norharman). Acta Crystallogr C. 2011 Jul;67(Pt 7):o241-3. doi: 10.1107/S0108270111021706. Epub 2011 Jun 23. PubMed PMID: 21727633.

6: Haghdoost-Yazdi H, Hosseini SS, Faraji A, Nahid D, Jahanihashemi H. Long term exposure to norharman exacerbates 6-hydroxydopamine-induced parkinsonism: possible involvement of L-type Ca2+ channels. Behav Brain Res. 2010 Dec 20;215(1):136-40. doi: 10.1016/j.bbr.2010.07.011. Epub 2010 Jul 16. PubMed PMID: 20638417.

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