Flibanserin Hydrochloride powder (147359-76-0)HPLC≥98%

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Flibanserin Hydrochloride powder (147359-76-0)HPLC≼98% 01

Overview

Flibanserin powder is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin Hydrochloride has been associated with a low rate of minor serum aminotransferase elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.

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Flibanserin Hydrochloride powder (147359-76-0)

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Flibanserin Hydrochloride powder (147359-76-0)

Base Information Name

Flibanserin Hydrochloride powder

CAS

147359-76-0

Purity

98%

Chemical name

Flibanserin Hydrochloride

Synonyms

BIMT 17 Hydrochloride; BIMT 17BS Hydrochloride; 1-(2-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benz o[d]imidazol-2(3H)-one Hydrochloride

Molecular Formula C20H21F3N4O.ClH Molecular Weight

426.863

Melting Point

>225°C

InChI Key

XGAGFLQFMFCIHZ-UHFFFAOYSA-N

Form

Solid

Appearance

White to Pale Yellow

Half Life

≈11 hours

Solubility

DMSO (Slightly), Methanol (Slightly)

Storage Condition

Room Temperature

Application

Flibanserin Hydrochloride is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women (1,2).

Testing Document Available

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Flibanserin Hydrochloride powder (147359-76-0)

General Description Flibansetrin Hydrochloride powder has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin Hydrochloride binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), flibanserin Hydrochloride may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also 2/4

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moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing. Flibanserin Hydrochloride is sold under the trade name Addyi and indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty

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Flibanserin Hydrochloride powder powder

(147359-76-0) History Flibanserin powder is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder drug by Sprout Pharmaceuticals.

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Flibanserin Hydrochloride powder (147359-76-0)

Mechanism Of Action Flibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), flibanserin may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing.

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Flibanserin Hydrochloride powder (147359-76-0)

Application For the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women.

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Flibanserin Hydrochloride powder (147359-76-0)

More research 3/4

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Adverse events are more common among women taking flibanserin. The majority of adverse events were mild to moderate. The most commonly reported adverse events included dizziness, nausea, feeling tired, sleepiness, and trouble sleeping.

Drinking alcohol while on flibanserin may result in severely low blood pressure (low blood pressure that produced symptoms after 2 glasses of wine occurred in 17%).

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Flibanserin Hydrochloride powder (147359-76-0)

Document Download COA

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Flibanserin Hydrochloride powder (147359-76-0)

Reference 1.

2.

3.

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Gelez, H., et. al.: (2013) Psychopharmacology 230 :639-52.

Katz, M., et. al.: (2013) J. Sex. Med. 10, 1807-15 Flibanserin (Addyi): Is It Female Viagra?

Product Catalog

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