beta-Nicotinamide mononucleotide (1094-61-7)

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beta-Nicotinamide mononucleotide (1094-61-7) Overview Nicotinamide mononucleotide ("NMN", "NAMN", and "β-NMN") is a nucleotide derived from ribose and nicotinamide.Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH).

Chemical Base Information Name

beta-Nicotinamide mononucleotide

CAS

1094-61-7

Purity

98%

Chemical name

beta-Nicotinamide mononucleotide nicotinamide mononucleotide 1/4

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1094-61-7 beta-NMN nicotinamide ribonucleotide

Synonyms

3-Carbamoyl-1-[5-O-(hydroxyphosphinato)-β-D-ribofuran osyl]pyridinium

Molecular Formula

C11H15N2O8P

Molecular Weight

334.221 g/mol

Melting Point

>96°C

InChI Key

DAYLJWODMCOQEW-TURQNECASA-N

Form

Solid

Appearance

White to Yellow Solid

Half Life Solubility

Methanol (Slightly), Water (Slightly)

Storage Condition

Hygroscopic, -20˚C Freezer, Under Inert Atmosphere

Application

Nicotinamide mononucleotide (“NMN”, “NAMN”, and “β-NMN”) is a nucleotide derived from ribose and nicotinamide.

Testing Document

Available

(1094-61-7) General Description beta-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice.

It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

(1094-61-7) History Beta-Nicotinamide mononucleotide (NMN) is an intermediate of NAD+ biosynthesis produced from nicotinamide through nicotinamide phosphoribosyltransferase (NAMPT) and also referred to as NMN or nicotinamide ribotide. In recent studies of NMN applications to prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc., it has become one of hottest biomarkers on discussion for anti-aging, lately.

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(1094-61-7) Mechanism Of Action beta-Nicotinamide mononucleotide (β-NMN) is a biosynthetic precursor of nicotinamide adenine dinucleotide (NAD+) known to promote cellular NAD+ production and counteract age-associated pathologies associated with a decline in tissue NAD+ levels.

(1094-61-7) Application Aging cells. Indeed, past work in Imai’s lab has shown that giving beta-Nicotinamide mononucleotide to older mice has beneficial effects on metabolism throughout the body, including positive effects in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight, and activity levels.

(1094-61-7) More research Aging cells. Indeed, past work in Imai’s lab has shown that giving beta-Nicotinamide mononucleotide to older mice has beneficial effects on metabolism throughout the body, including positive effects in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight, and activity levels.

(1094-61-7) Document Download COA

(1094-61-7) Reference 1, Bogan, KL; Brenner, C (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition”.

Annual Review of Nutrition. 28: 115–30. doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.

2, Brazill, JM; Li, C; Zhu, Y; Zhai, RG (June 2017). “NMNAT: It’s an NAD+ synthase… It’s a chaperone… It’s a neuroprotector”. Current Opinion in Genetics & Development.

44: 156–162. doi:10.1016/j.gde.2017.03.014. PMC 5515290. PMID 28445802.

3, “Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice”. Cell Metabolism. 13 December 2016.

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4, Stipp, David (March 11, 2015). “Beyond Resveratrol: The Anti-Aging NAD Fad”.

Scientific American Blog Network.

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