Leiden Amsterdam Center for Drug Research The Leiden Amsterdam Center for Drug Research (LACDR) was founded in 1985 as a co-operation between the Faculties of Science of Leiden University and of the VU University Amsterdam. The LACDR is specialised in innovative drug research including target finding for the development of drugs for various diseases using genomic and metabolomic approaches. The focus lies on increasing knowledge and expertise that is crucial for drug discovery. In collaboration with the Leiden University Medical Center newly discovered drugs are evaluated. Understanding of drug action as the basis for efficacy and safety of drugs is an important issue.
The LACDR collaborates intensively with the industry, in par-
Internationally, the LACDR has a good reputation, being one of
ticular in the framework of the Top Institute Pharma.
the few institutes covering the whole range of drug research.
A Scientific Advisory Board, with members from industrial com-
The LACDR has three research clusters in Amsterdam and the
panies and other academia, advises the LACDR about its strategy
following six clusters in Leiden.
Graduate School of Science P.O. Box 9502 2300 RA Leiden www.science.leidenuniv.nl/graduateschool
and new research possibilities. This approach has contributed to the high societal relevance of the research in the LACDR, which
has resulted in the remarkable fact that 50% of the organizationâ€™s
Developing novel analytical technologies to study biological sys-
budget is externally funded. Intensive collaboration with the
tems, such as metabolomics, identifying pathways and networks
Medical Centers means that the research at the LACDR covers
at the cellular, tissue and organ level, is the aim of Analytical
the whole path from target finding, to synthesis and testing of
Biosciences. These technologies lead to a better understanding
possible new drugs.
of health and disease and provide new insights as a basis for the development of intervention strategies.
Graduate School of Science
Leiden Amsterdam Center for Drug Researsh Gorlaeus Laboratorium Einsteinweg 55 2333 CC Leiden www.lacdr.nl
The study of heart disease, in particular on the mechanisms of
This research division focuses on ‘systems pharmacology’ with
atherosclerosis is the focus of Bio Pharmaceutics. By identifying
the aim to predict in vivo drug effects in man. To this end
genes and proteins involved in atherosclerosis, new targets for
mathematical models are developed which describe the actions of
the delivery of drugs and new techniques like gene therapy or
the drug in and on the integral biological system. These models
vaccination for preventing or treating cardiovascular disease can
constitute the scientific basis for the design of novel biologically
active compounds and their development into drugs. The interaction between small molecules (hormones,
neurotransmitters, medicines) and proteins (recep-
Understanding of the interaction between a drug and its recep-
Important in drug development are the mechanisms of apoptosis
tors, transport proteins, etc) is the basis of life and
tor at the atomic level is the ultimate goal of the research in this
and cellular signal transduction. The research group Toxicology
disease in every organism. It is now emerging that,
cluster. The adenosine receptor plays a central role in many of the
identifies potential new targets that can be used to pharmacologi-
next to ‘traditional’ receptor affinity, the total duration
projects. When such receptors bind adenosine, they can become
cally modulate wanted and unwanted cytotoxity.
of this interaction, the so-called residence time, can
involved in muscle contraction and the demand for oxygen.
have a crucial impact on the effectiveness and selectivity of a drug molecule. Dynamic flow and metabo-
Drug Delivery Technology
lism in the human body often prevent drug molecules
Finding new strategies for the delivery of biologically active
from reaching equilibrium conditions that are readily
compounds in the right dosage, at the right time and to the right
attained in the test tube (in vitro). The compounds’
place is the main topic of Drug Delivery Technology. The interac-
kinetic behaviour might in fact be the guiding principle
tions of these new strategies with biological systems, such as skin,
to obtain a desired and durable effect in vivo. Dr.
are also tested.
Laura Heitman investigates this, i.e., the kinetics of drug-receptor interactions to increase the effectiveness of future therapies. Ultimately, she thinks this will result in a higher success rate of drug candidates in clinical trials, which, for sure, will benefit patients.
Graduate School of Science