Issue 191 - Dr. Richard Downs

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DR. RICHARD DOWNS: A PIONEER IN DENTAL SLEEP MEDICINE AND THE REVOLUTIONARY POWER OF HYPOCHLOROUS ACID

PG 36

UNLOCKING HUMAN POTENTIAL: A CONVERSATION WITH MICK SAFRON, CEO & FOUNDER OF THE BIOHACKERS WORLD CONFERENCE & EXPO

PG 26

OPTIMIZING HEALTH THROUGH REGENERATIVE THERAPIES - DR. JOSEPH PURITA INTERVIEWED BY MICHELE HUGHES OF AGELESS AND TIMELESS

PG 76

"Ultimately, whether through the gentle yet powerful science of hypochlorous acid sprays like HypoNasal, or the innovative expansion of our airways, the goal remains the same: to empower individuals to breathe easier, sleep soundly, and live healthier, more vibrant lives. The journey is ongoing, but the potential to transform well-being is immense, and dentistry is poised to be a leading force in this vital evolution."

Publisher: John Highland

Editor In Chief: Hannah H.

Graphic Designer: Laura Poyner

Contributing Authors: Ocean Eagle, Evelyn Flaharty, Riley George, Michele Hughes, Julia Smila

PUBLICATION TEAM EXECUTIVE TEAM

Vice President of Development: Mark Carvalho

Business Director: Rob Fletcher

Fractional Marketing Officer: Craig Handley

Advisory Board: Dr. Ken Davis

Executive Assistant: Michelle Richardson

CONTRIBUTORS MAGAZINE

A LETTER FROM THE EDITOR

Our mission and purpose at TopDoctor Magazine is to foster connections within the health and wellness community and empower our readers to make wellinformed healthcare and lifestyle decisions. We pride ourselves on being the ultimate resource for interviews with health and wellness leaders, trending medical news, and healthy living topics.

We understand that choosing a healthcare provider is a crucial decision. Our in-depth interviews with esteemed doctors and medical professionals aim to bridge the gap between them and their clients. By providing our readers with personal insights, philosophies, and areas of expertise, we facilitate a deeper understanding of the individuals responsible for your health and well- being. We also strive to highlight our outstanding practitioners, showcasing their dedication to their patients and contributions to the medical community.

The field of medicine is constantly evolving, with new practices, therapies, and technologies emerging at a rapid pace. At TopDoctor Magazine, we strive to keep you updated on the latest advancements in the medical world. Our comprehensive coverage of trending medical news equips both doctors and patients with the knowledge they need to make informed choices about healthcare options.

Building strong connections within the medical community is essential for enhancing patient care and driving medical progress. Our magazine serves as a bridge, connecting medical companies with doctors and vice versa. By facilitating these connections, we aim to catalyze collaborations that can lead to innovative solutions and improved healthcare outcomes for everyone.

It is our firm belief that well-informed individuals make better decisions about their health. By providing you with insights into established and emerging medical trends and technologies, we empower you to take an active role in your healthcare choices. Whether you are a healthcare professional seeking to stay updated on the latest advancements or a patient eager to make informed decisions about your well-being, TopDoctor Magazine is here to support you.

In every issue, we strive to uphold the highest standards of journalistic integrity, accuracy, and relevance. Our dedicated team of writers, editors, and medical experts work tirelessly to bring you well-researched and compelling content that is both educational and engaging. Moreover, our graphic design team is committed to delivering an aesthetically pleasing reading experience where captivating design seamlessly merges with informative content, ensuring each issue becomes an engaging journey of discovery.

As we embark on this mission to serve as your trusted source of medical information and insights, we encourage you to join us on this exciting journey. Your feedback and suggestions are invaluable to us, and we look forward to hearing from you.

Thank you for being a part of the TopDoctor Magazine community. Together, let us embrace knowledge, forge connections, and make informed decisions to lead healthier lives.

With warmest regards, Hannah

TABLE OF CONTENTS

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HONORING THE RESILIENCE OF CANCER SURVIVORS IN NATIONAL CANCER SURVIVOR MONTH

TRAUMA IN THE WOMB AND EPIGENETICS

UNLOCKING HUMAN POTENTIAL: A CONVERSATION WITH MICK SAFRON, CEO & FOUNDER OF THE BIOHACKERS WORLD CONFERENCE & EXPO

DR. RICHARD DOWNS: A PIONEER IN DENTAL SLEEP MEDICINE AND THE REVOLUTIONARY POWER OF HYPOCHLOROUS ACID

STRESS AND ITS EFFECT ON AGING

WHERE SPIRIT LEADS AND SCIENCE ELEVATES: THE ULTIMATE WELLNESS™ CONFERENCE RETURNS TO THE ICONIC FAENA FORUM IN MIAMI BEACH ON SPETEMBER 2628, 2025

OPTIMIZING HEALTH THROUGH REGENERATIVE THERAPIES - DR. JOSEPH PURITA INTERVIEWED BY MICHELE HUGHES OF AGELESS AND TIMELESS

HONORING THE RESILIENCE OF CANCER SURVIVORS IN

NATIONAL CANCER SURVIVOR MONTH

June is a month marked not only by the arrival of summer but also by a powerful tribute to human strength, determination, and hope. It is National Cancer Survivor Month, a time dedicated to celebrating the millions of individuals who have faced a cancer diagnosis and come out the other side as survivors.

June holds even more profound meaning for me: it’s my birthday month. Each year, as I celebrate my birth, I also celebrate my rebirth as a thyroid cancer survivor. This personal connection makes National Cancer Survivor Month especially important to me, symbolizing resilience, renewal, and the gift of life.

As someone who has personally walked this path, I understand the deep impact cancer can have on every aspect of your life. As a thyroid cancer survivor, my journey, like so many others, was filled with fear, uncertainty, and ultimately, resilience. Sharing this from both a personal and broader perspective allows me to connect deeply with the stories of other survivors and to honor the incredible strength that defines us all.

THE MEANING OF SURVIVAL

Surviving cancer is far more than reaching remission or completing treatment. For many, survival begins the moment they hear the words, "You have cancer." From that point forward, every scan, treatment, side effect, and emotional hurdle becomes part of the survival story. Cancer doesn’t just affect the body; it impacts the mind, the emotions, and the spirit.

When I was diagnosed with thyroid cancer, my world changed in an instant. Suddenly, every plan, every dream, every routine was overshadowed by this new reality. The days that followed were a blur of doctor appointments, tests, and difficult conversations. And yet, within that chaos, a quiet resolve began to grow. I realized that surviving cancer wasn’t just about physical healing—it was about reclaiming my identity, my strength, and my voice.

Survivors often speak of life "before cancer" and "after cancer," recognizing the profound transformation the experience brings. Many reevaluate their priorities, careers, relationships, and purpose. Some discover new passions or reengage with old ones, driven by a fresh appreciation for life. But this transformation is rarely easy. It comes with physical pain, emotional strain, and an often-lonely road through uncertainty.

THE SILENT STRUGGLES

While survivors may outwardly seem strong and resilient—and indeed, they are—there are silent struggles many face long after the cancer is gone. Fatigue, chronic pain, and the long-term side effects of treatment can linger for years. Emotional tolls like anxiety, depression, and fear of recurrence are common, yet not always visible to the outside world.

I remember vividly the anxiety and stress that come with follow-up scans and waiting for test results—that pit in your stomach as you wonder if your body has betrayed you once again. I’ve also felt the dissonance between how others see me and how I feel inside. People often say, "You look great! You must be feeling better," not knowing the quiet battles I still face daily.

Many survivors speak of the anxiety and stress related to follow-up scans as a constant reminder that cancer could return. Others describe the challenge of reintegrating into everyday life, dealing with career interruptions, insurance hurdles, or even shifts in

how friends and family perceive them. For young survivors, the journey can include dealing with infertility, missed milestones, and the challenge of finding peers who truly understand.

STRENGTH THROUGH COMMUNITY

Despite these challenges, the cancer survivor community is a remarkable testament to human resilience. Support groups, survivor networks, and online communities have become lifelines for many. In these spaces, survivors share their stories, offer advice, and provide comfort to those just beginning their journey.

These connections often become powerful friendships built on empathy and shared experience. For many, helping others becomes a key part of their healing. Survivors often become advocates, fundraisers, and volunteers, determined to raise awareness and pave the road for those who follow.

I’ve found tremendous strength in connecting with others who understand this path. Whether through social media, support groups, or just one-on-one conversations, something is healing about sharing your truth and hearing someone else say, "Me too."

STORIES THAT INSPIRE

Note: The stories below are inspired by the real experiences of countless survivors I’ve read about, listened to, and connected with through survivor forums, documentaries, and support groups. While the individuals mentioned are fictional composites, their journeys reflect the authentic emotional and physical challenges many survivors face, including my own.

Take, for example, a mother of three who was diagnosed with breast cancer at 32. She endured chemotherapy, surgery, and radiation while still managing the daily needs of her young children. Today, she runs marathons, gives motivational talks, and mentors newly diagnosed patients.

Or consider the story of a teenager who faced leukemia just as he was preparing to graduate from high school. While his friends were picking out college dorms, he was learning about blood counts and bone marrow biopsies. Today, he is a doctor working in pediatric oncology, using his experience to help others.

Then there are countless others—fathers, daughters, grandparents, athletes, artists, business leaders, and teachers—who, despite the disruption cancer caused in their lives, continue to lead, inspire, and thrive.

And then there’s me. A survivor who never imagined cancer would be part of my story. But it is, and now I carry that title with pride—not as a label of what I endured, but as a badge of the strength I discovered within myself. I refer to my scar on my throat as my “badge of honor”.

LIFE AFTER TREATMENT

The end of treatment is often imagined as a finish line, but for survivors, it’s usually just another beginning. Adjusting to "the new normal" can be unexpectedly difficult. There is often an expectation, both internal and external, to "bounce back" quickly. But healing takes time.

Some survivors experience survivor’s guilt, wondering why they lived when others did not. Others feel pressure to be perpetually positive, even when they’re still dealing with real pain and fear. Raising awareness about these realities helps dismantle the stigma and opens the door to better mental health support and understanding.

Physical rehabilitation, ongoing screenings, and continued medication may become permanent parts of life. But so too does a renewed sense of purpose. Survivors frequently report living more intentionally, cherishing relationships, and savoring life’s small moments.

Personally, I came to see my cancer as a “blessing in disguise.” It gave me a deeper appreciation for life and inspired me to live with greater purpose and intention. Today, I’m in the best health of my life—because I made the decision to prioritize my well-being and take control of my healing journey.

THE ROLE OF CAREGIVERS AND FAMILIES

Behind every survivor is a network of supporters who also deserve recognition. Caregivers, whether spouses, parents, siblings, or friends, endure their own emotional and physical tolls. They provide comfort during chemotherapy sessions, keep track of medications, manage meals, and often put their own lives on hold.

Family members ride the rollercoaster of fear and hope alongside the patient. Their strength is vital to the healing process, yet their contributions can go unnoticed. National Cancer Survivor Month is also a time to thank and support these unsung heroes.

I was blessed with a circle of loved ones who stood by me through every step. Their faith, patience, and love were as crucial to my recovery as any medical treatment. They reminded me I was never alone.

MOVING FORWARD AS A SOCIETY

As we honor survivors, it’s crucial to remember the work that still lies ahead. Advances in treatment have significantly improved survival rates, but disparities in care persist. Access to early detection, cutting-edge therapies, and follow-up support varies based on geography, income, and race.

There is also a need for greater investment in survivorship care. Mental health support, vocational rehabilitation, and long-term medical monitoring must be recognized as essential components of post-cancer care. Employers, healthcare systems, and policymakers all have a role to play in ensuring that survivors are not forgotten after their last treatment.

RAISING AWARENESS AND INSPIRING ACTION

National Cancer Survivor Month is an opportunity not just to celebrate, but to educate. It is a time to elevate survivor voices, encourage screenings, and fund research. It’s a time to share stories on social media, participate in fundraising events, and reach out to loved ones affected by cancer.

As a thyroid cancer survivor, I’ve learned that sharing our stories is one of the most powerful things we can do—not only to heal ourselves but to uplift others. When I was first diagnosed, I felt a wave of isolation and fear that seemed insurmountable. But as I opened up about my journey—through the surgeries, the uncertainty, the slow climb back to wellness—I found connection, strength, and even purpose. Sharing my experience helped me reclaim power over a narrative I didn’t choose, and it reminded others that they’re not alone.

If you know someone who has faced cancer, I urge you to listen intently. Your presence can be a lifeline. And if you can contribute in any way—by advocating for better care, supporting research, or simply showing up—you’re not just helping one person. You’re helping all of us build a future filled with hope, compassion, and possibility.

CONCLUSION

As National Cancer Survivor Month, June stands as a beacon of hope and a call to action. It reminds us that while cancer may mark a chapter in someone’s life, it does not define their entire story. Survivors show us what it means to live fully, love deeply, and fight bravely. They teach us about the power of community, the importance of compassion, and the strength of the human spirit.

As a thyroid cancer survivor, I am living proof of that strength. And I carry with me the stories of others—those still fighting, those we’ve lost, and those thriving today. Let us honor them—not just this month, but always. Let us continue to build a world where cancer is not a death sentence, but a challenge that can be met with courage, support, and the unwavering belief in tomorrow.

TRAUMA IN THE WOMB EPIGENETICS AND

What if, while you were pregnant, you could see into the future of your unborn child? What if you recognized the pain and suffering you saw was your own, and they were carrying it forward? How guilty would you feel? What would you have done differently during your lifetime before you chose to bring a child into this world and during the pregnancy?

I believe we are genetically trauma hardwired. Depending on the origins of your genes, this hardwiring can dictate how you choose to respond to the world, culture, and daily circumstances. My awareness and interest in epigenetics were sparked during the pandemic. I could not understand how humans could not or would not see what was so crystal clear to me. Then it hit me, They Couldn’t! Genetically, they were responding to the fear being pushed into the hearts of humanity based on what their grandparents and their great-great-grandparents endured.

If your family history is rooted in a particular culture that was constantly at war, then fear, anxiety, suffering, and insecurity are your genetic normal. You may stay trapped in cyclical cycles of suffering and simply try to survive the day. If your family of origin was ruled by communist governments that ruled with an iron fist and constant threats to stay in line or face prison or death, you may not feel you have a voice to speak up or speak out against tyranny. Most people I work with or attend my retreats have closed Throat Chakras and feel they don’t have a voice that matters.

Maybe you have been very sensitive to loud noises your whole life. When you hear something loud, you actually get a cellular reaction that triggers a fear response. Where did that come from? If we can’t find the root cause, we remain a slave to that energy of Inner-Chi. If your distant relatives were constantly woken in the middle of the night by bombs exploding, you may have dreams that relate to this, and they wake you in the middle of the night, terrorized. My exwife would have night terrors, and she would wake up horrifically screaming. Nothing I know of happened to her in this lifetime, so she possibly brought it in genetically from many lives ago in her lineage.

One of my children began stealing at a very young age, and that went on into their teenage years. I gave my children a very abundant life and lacked nothing. My ex or I did not teach this behavior. It was brought into this lifetime organically. Maybe it’s a karmic thing on a soul level and part of what this being came to work on. I feel it’s genetic, though. My origins are based in poverty and struggle. My grandparents on both sides were impoverished and never had two nickels to rub together. Addiction ran deep on my father’s side, also. It takes a very strong person who is ready to be better than their genetic coding.

When children are in the womb, mothers and fathers have an opportunity to help their child heal their family lineage by creating safety within the union. Whether the parents are together or not, they have a great responsibility to ensure their unborn child will enter this world feeling emotionally supported and loved. When parents fight and argue during pregnancy, it creates hardwired issues that may stay with that child subconsciously for their entire life. It took me until the age of 50 to finally feel I was free from negative energies that didn’t belong to me. Both of my parents were slaves to their lineage, and my father died with that energy deeply rooted in his soul.

How do we break down our genetic coding and rebuild it in a healthier form? Awareness leads to preparedness. Researching family genealogy might be a good place to begin understanding patterns in your life because patterns don’t lie. Seeking guides to help us turn inward and see the unseen and buried disease can create opportunities to cut the cords of energy we have assigned to the old story. Until we begin this journey, our story keeps doing push-ups, waiting for us to slip up. This energy attacks us based on the triggers we see, smell, hear, taste, and feel by sending a shot of toxicity to the place in our body where it is stored. This shuts down our parasympathic and immune systems while disconnecting communication synapses between the brain and nervous systems.

We immediately get stuck in fight or flight cycles; if we do not understand why, we can get stuck in victim mode. We blame the world that surrounds us, but it’s our responsibility to choose to heal our lineage. Many end up turning to outside fixes, which become either bandaids they need to keep using or create new issues. Treating the symptom is Western medicine’s brainwashed programming. Big Pharma has been around for 150 years and has never cured anything. I feel we have everything within us to heal ourselves naturally. I do not support the psychedelic movement happening, as I think it just numbs the pain and treats the symptoms. It’s bypassing in my view.

I guide people in taking ownership of their energy or inner-Chi. As adults, we are responsible for the energy we choose to feed the beast within on a cellular level. We have to change one thing… Everything! Mentally, physically, emotionally, and spiritually, we must remove everything and everyone that does not feed our souls with healthy fuel. It takes courage and faith in the unknown to embark on a journey like this. Humans are deeply brainwashed to believe they need something to fix them.

It all begins with Self-Love. Changing your diet by researching all the food that enters your body will help detox you physically if you make the necessary changes. You must begin flooding the mind with healthy visions and teachings. Throwing away your television and deleting subscriptions is a good place to start. Learning how to use the breath to still yourself can help you tap into higher states of consciousness. Spirituality is not something you are, it’s something you do. Self-regulation through conscious breathing is the best form of self-control and self-mastery, in my opinion. We all have the ability to gain control of our emotions simply by learning how to become present. There is no foot in the past or the future; we are just completely living in the moment where everything exists.

Breaking the genetic chains programmed within us for generations is the basis of the work I do as I guide others to their truth hidden beneath trauma, abuse, abandonment, and neglect from both this lifetime and past lifetimes. You have to be ready to rectify stubborn patterns that keep you addicted to suffering. It won’t go away overnight, so be patient with yourself. But, stay the course and be willing to have your world get smaller until you feel empowered to play once again as the child plays.

AGELESS TIMELESS

UNLOCKING HUMAN POTENTIAL

A CONVERSATION WITH MICK SAFRON, CEO & FOUNDER OF THE BIOHACKERS WORLD CONFERENCE & EXPO AND

CEO Ageless and Timeless and host of the Ageless and Timeless podcast

At the forefront of human optimization and performance, Mick Safron—the visionary founder of Biohackers World—is building more than just conferences. He’s igniting a global movement. In this exclusive interview with TopDoctor Magazine, Mick shares his journey, daily habits, and bold vision for the future of biohacking.

Understanding Biohacking: Mick, can you share your personal journey into biohacking and what initially inspired you to delve into this field?

I was born and raised in Ukraine, in a family of entrepreneurs. From a young age, I was fascinated by technology and futuristic concepts. That passion followed me into adulthood and led me to Silicon Valley in 2013, where I immersed myself in the world of startups, innovation, and wellness. I saw clearly that our greatest wealth is our health—not just physical, but mental and emotional. Biohacking gave me a structured, evidence-based framework to take full ownership of my biology and life. And most importantly, I found support in a growing community of like-minded, health-conscious individuals—whether it's family, colleagues, or our thriving Biohackers World community. That sense of connection and shared mission continues to inspire me.

Defining Success in Biohacking: In your experience, how do you define success in biohacking? Is it solely about physical performance, or do mental and emotional aspects play a role too?

Biohacking is holistic. Success isn’t defined by a six-pack or faster reaction times—it’s about how aligned, present, and resilient you feel. Physical optimization is important, but mental clarity, emotional regulation, and even spiritual awareness are essential components. Community support is also a huge factor. When you surround yourself with others who are invested in their wellbeing, like in the Biohackers World network, it accelerates your own growth.

Personal Biohacks That Work: Biohacking is deeply personal. What is one powerful biohack that has had the most impact on your own well-being—and why?

One powerful combination that has transformed my life is intermittent fasting, daily breathwork, and sleep tracking. Fasting gives my body time to repair and keeps my mind sharp. Breathwork helps me reset my nervous system and enter each day with clarity. But perhaps the most underestimated hack is optimizing sleep—it's the foundation for everything. I track my sleep patterns religiously using wearable tech to improve sleep depth and quality. Deep rest equals peak performance.

Inside Their Daily Routine: Can you walk us through a typical day in your life? How do you integrate your favorite biohacks into your routine to stay energized, focused, and aligned?

My day starts with sunlight exposure, hydration, and light movement—usually walking and breathwork. I fast through the morning, block time for deep work, and use blue light blockers to protect my circadian rhythm when working on a screen. I rely on AI tools for time and focus management. In the evening, I unplug to be fully present with my loved ones. Every choice is intentional and based on tracking and feedback. That’s what keeps me aligned and high-performing.

Practical

Tips for Beginners: For someone new to biohacking, what are three simple, practical steps you would recommend they start with to enhance their health and wellbeing?

1. Get morning sunlight to reset your internal clock.

2. Remove processed sugar to balance your energy and mood.

3. Start tracking your sleep to understand your body’s recovery needs.

And most importantly—join the Biohackers World Conference & Expo. Surround yourself with healthy, successful people. That energy alone is transformative.

Myth Busting: There are many myths surrounding biohacking. What are some of the most common misconceptions you encounter, and how do you help people see beyond them?

The biggest myth is that biohacking is only for tech elites or requires expensive gear. That’s false. Some of the best hacks— sunlight, breathing, sleep optimization—are free. At Biohackers World, we share accessible tips daily on our Instagram and social media. Our community is here for anyone willing to take ownership of their health. You just have to start.

Integration of Science and Lifestyle: How do you see the integration of science and lifestyle changes evolving in the biohacking space, especially for people unfamiliar with the concept?

It’s evolving fast. At Biohackers World, we make this knowledge accessible by keeping our doors open with affordable entry prices and events, both in-person and digital. Our mission is to bring biohacking to every local community and make lifestyle optimization something everyone can achieve—not just scientists or wellness insiders. We simplify the science into actions anyone can adopt today.

Trends to Watch: What trends are you currently seeing in the biohacking community? Are there any emerging technologies or practices you believe will transform health and wellness in the next few years?

The future is incredibly exciting. We’re seeing huge momentum behind peptides, quantum energy devices, and hyper-personalized testing, covering everything from gut health to emotional state. Add to that AI-powered coaching and biological data integration, and you have a revolution in how people take care of themselves. We're no longer guessing—now we’re customizing every aspect of life optimization.

Aging and Longevity: With your strong focus on agelessness and vitality, how do you believe biohacking can help people not just live longer, but live better as they age?

We’re focused on healthy aging, not just longevity. That means preserving mental sharpness, physical vitality, emotional balance, and even deepening your spiritual consciousness. Biohacking tools—from red light therapy to sleep optimization and smart supplementation—help maintain youthfulness. But equally important is nurturing mental health and purpose. That’s how you thrive, not just survive.

Ethical Considerations: As biohacking becomes more mainstream, what ethical considerations do you believe are critical, particularly regarding safety, accessibility, and equitable access to tools?

Ethics are everything. We must prioritize safety, affordability, and transparency. Today, AI, influencers, and content creators shape a lot of the narrative in health. While that’s powerful, it’s also risky if driven purely by profit. Unfortunately, large corporations often lose sight of true preventive health. At Biohackers World, we strive to stay mission-driven, focused on education, not exploitation.

Building a Movement: Biohackers World is more than an event—it’s a thriving community. How do you cultivate a culture of inclusivity, collaboration, and innovation within this space?

Our secret is diversity of thought and openness of spirit. We welcome all backgrounds—scientists,

spiritual seekers, tech founders, first-timers. Everyone can find value if they come with an open mind and critical thinking. That’s true freedom: to learn, explore, and choose your path. It’s not just about tools— it’s about empowerment.

Community and Collaboration: Why is collaboration within the biohacking community so important, and how does it elevate the experience and outcomes for attendees and partners alike?

I've seen it firsthand: people who met at our events four or five years ago are now co-founders, showcasing their startups on our expo floors. That’s the power of a shared vision. Collaboration isn’t just networking—it’s about building new ecosystems that support both personal and economic growth. I’m deeply proud of that.

U.S. Cities & Community Energy: You’ve hosted events in cities like Los Angeles, Austin, and Miami. What makes each city unique, and how do you decide where to bring Biohackers World next?

Every city has its own health energy. LA is performance-focused. Miami is fast-growing and global. Now we’re pioneering Chicago on July 26–27, 2025, at Sofitel Magnificent Mile. And in 2026, we’re adding New York City to our series alongside LA, Chicago, and Miami. We go where the energy is strong and the communities are ready to evolve.

Why Biohackers World Stands Out: There are many health and wellness expos out there. What makes Biohackers World different—and why do so many thought leaders and practitioners keep coming back?

We’re a community-first event, not a personality-driven show. Our doors are open to everyone, not just celebrities or influencers. We focus on connection, education, and real transformation. That authenticity keeps people coming back—and building with us.

Beyond the Conference: Are there plans to expand your community through digital platforms, online education, or year-round programs beyond the live events?

Absolutely. Our vision is to bring Biohackers World to every continent, through digital platforms, local events, and hybrid models. We're expanding into online education, accelerator programs, and yearround challenges to keep people connected and growing no matter where they are.

Future Vision: Looking ahead, what is your vision for the future of biohacking? How do you see it evolving over the next 5 to 10 years, especially in relation to mainstream medicine and preventive health?

In the next decade, biohacking will evolve into a complete infrastructure. Picture local wellness centers, concierge practitioners, preventive health coaches, and AI-driven health guidance—all as accessible as Googling a recipe. Biohackers World is pioneering that shift. We're laying the groundwork for a proactive, personalized, and purpose-driven health system that empowers people to live longer, stronger, and more consciously.

ABOUT MICK SAFRON:

Mick Safron is the CEO and Founder of Biohackers World, a global conference and community platform advancing the frontiers of longevity, wellness, and human optimization. Originally from Ukraine, Mick was raised in a family of entrepreneurs and developed a deep interest in technology, health, and human potential from an early age.

In 2013, he moved to Silicon Valley, where he worked with companies like Google and Facebook. Those experiences shaped his vision of combining innovation, data, and community to drive meaningful health outcomes. Inspired by both personal curiosity and the growing global interest in biohacking, Mick launched Biohackers World to make advanced health tools and education accessible to everyone—not just elite circles.

Today, Biohackers World is more than a conference—it’s a movement. With events in cities like Los Angeles, Miami, Austin,

Chicago, and New York, it brings together scientists, startups, investors, and health enthusiasts to explore cutting-edge solutions for living longer and stronger.

ABOUT MICHELE HUGHES:

Michele Hughes is the visionary founder of Ageless and Timeless and the dynamic host of the Ageless and Timeless podcast. As a monthly contributor to Top Doctor Magazine, she offers powerful insights on wellness, longevity, and living fully at every stage of life. With a deep passion for health, vitality, and a role model for timeless elegance, Michele empowers audiences to embrace their highest potential and live with purpose and grace. Michele's podcast, Ageless and Timeless, was one of 20 Inaugural Podcasts selected for the Muscle and Fitness Plus platform that began in 2023.

For more information, please reach out to express interest in being a potential guest on the Ageless and Timeless podcast or to be featured in the Top Doctor Magazine Ageless and Timeless column with Michele Hughes. For podcast collaborations or to have Michele Hughes on your show, please contact her at:

Email: themichelehughescompany@gmail.com

Website: www.agelessandtimeless.com

Instagram: @agelessandimeless

LinkedIn: https://www.linkedin.com/in/michele-hughes-83a3b935/

Facebook: https://www.facebook.com/michele.hughes.186

Ageless and Timeless podcast, on YouTube, iTunes, Spotify, and wherever podcasts are available.

DR. RICHARD DOWNS

A PIONEER IN DENTAL SLEEP MEDICINE AND THE REVOLUTIONARY POWER OF HYPOCHLOROUS ACID

FROM IOWA ROOTS TO GLOBAL HEALTH INNOVATIONS

Dr. Richard Downs, DDS, FAGD, FICOI, D-GMDIA, D-ASBA, embodies a remarkable journey of dedication and innovation within the realm of dental health and beyond. In an insightful conversation, Dr. Downs shared his life trajectory, from his formative years in rural Iowa to his distinguished career as a practicing dentist and his current groundbreaking work in developing wellness solutions. His story is a testament to a relentless pursuit of knowledge and a profound commitment to improving the well-being of others.

Growing up in a small town, Dr. Downs experienced the close-knit fabric of a rural community.

"I grew up in a little town called Montour, Iowa, right next to a reservation. My dad was good friends with the Native Americans living there. Montour was a rural small town with approximately 200 people," he said.

This upbringing instilled in him a grounded perspective that would undoubtedly shape his interactions with patients and colleagues throughout his career.

His academic path led him through Montour Grade School and Marshalltown High School before he earned his Bachelor of Science and Doctor of Dental Surgery degrees from the University of Iowa.

Even in his early academic pursuits, a spark of innovation was evident. "I spent two years at the community college in Marshalltown with a Workship Scholarship in chemistry. That is how I got interested in developing products. My chemistry background from the Workship Scholarship ignited my interest in innovation."

Following dental school, Dr. Downs dedicated three years to serving as a Navy dental officer, an experience he recalls with pride.

"I practiced three years in the Navy, right after dental school. I enjoyed my stay there. It was a great experience that I would do all over again."

This period not only refined his dental expertise but also instilled a sense of discipline and self-assurance. Reflecting on his decision to establish his own private practice in Iowa in 1978, he stated, "I felt more confident than most people who just started their practice immediately after graduation from dental school.”

After a distinguished 42 years in private practice, Dr. Downs retired from clinical dentistry in 2020. However, his passion for enhancing health and well-being ignited a new chapter focused on product development.

FROM ORAL CARE FOUNDATIONS TO THE HYPOCHLOROUS ACID REVOLUTION

Dr. Downs began his work in healthcare product development in 2012 with the co-founding of OraCare, a dental products company.

"I co-founded the OraCare company along with Dr. Robert Martino and Dr. Berdj Kaladjian in 2012 before I retired," he clarified. He played a vital role in the company's early formulations and growth. "When we started that company, I was very involved in helping establish our investment base.”

He expressed satisfaction with OraCare's current success and hinted at an upcoming innovative toothpaste. "The company is doing really well, and we're planning to launch a toothpaste in June, which will be revolutionary."

Building on this foundation, the COVID-19 pandemic spurred Dr. Downs to embark on a new independent venture, leading to the creation of USA-Guard and the development of his key product, HypoNasal Spray & Rinse: https://www.hyponasal.com/.

"We launched the USA-Guard and the HypoNasal product line a little after the start of the pandemic around 2020. I'm incredibly pleased with HypoNasal’s results so far."

THE REMARKABLE POTENTIAL OF HYPOCHLOROUS ACID

At the heart of Dr. Downs' current product line lies hypochlorous acid (HOCl), a naturally produced molecule renowned for its powerful antimicrobial properties and remarkable safety

profile. He emphasized the unique advantages of his HOCl-based products. HypoNasal is the only non-electrolysis produced HOCL nasal spray using ion-exchange technology. This product has no salt flavor or contaminants like hydrogen peroxide and acetic acid. Dr. Downs has named this unique HOCL “IONOXX™”

"You can spray this on your skin and don't have to rinse it off. You can spray it in your nose. It’s so safe, you can technically eat it. For instance, spraying it on your fruit from the store will kill the bacteria,” Dr. Downs explained.

He further differentiated his products from conventional disinfectants, highlighting the gentleness of HypoNasal products.

"On the other hand, quaternary ammonium compound products like the wipes you find at the stores are unsafe to put on your hands and skin. The HypoNasal products are one hundred times stronger than products like bleach, yet remain safe to breathe in, consume, and put on your skin."

These facts underscore hypochlorous acid's exceptional combination of efficacy and safety.

THE HYPOCHLOROUS ACID NASAL SPRAY: AIDING NASAL HEALTH AND BREATHING

Dr. Downs' hypochlorous acid nasal spray stands as a primary product aimed at promoting nasal health and potentially improving respiratory function. While adhering to regulations against making definitive medical claims, he shared compelling anecdotal evidence of its positive impact.

"Encouraged by the impressive results our users report, we are moving forward with clinical studies. We’ve observed a reduction in the size of the nasal turbinates, effectively opening the airway and improving breathing. Remarkably, both allergy sufferers and non-allergic individuals are experiencing these benefits,” he said.

He recounted powerful testimonials, including one from a lifelong allergy sufferer who experienced significant relief for the first time.

"I recently received a testimonial from a young woman who has suffered from allergies since childhood. She said it was the first time in her life she's been able to breathe through her nose," he shared.

He also noted the immediate positive feedback from multiple individuals who typically use nasal dilators, seeing noticeable results.

EXPANDING THE ARSENAL: HAND AND SURFACE SANITIZER

Complementing the nasal spray, Dr. Downs has also developed a hypochlorous acid-based hand and surface cleanser under the USA-Guard brand. He reiterated its safety and versatility,

emphasizing its ability to sanitize effectively without the need for rinsing or concern about any toxic nature.

ADDRESSING THE SILENT EPIDEMIC: SLEEP-DISORDERED BREATHING

Drawing upon his extensive dental expertise, Dr. Downs addressed the critical issue of sleep-disordered breathing and its far-reaching health implications. He highlighted the often-underestimated prevalence of sleep apnea and the crucial role dentists can play in its management.

"The CDC has labeled poor sleep as an unrecognized epidemic. That's why I wrote the book ‘Beautiful Faces: The Architects of Enhanced Attractiveness and Improved Human Breathing,’ co-authored by Dr. Joseph Zelk, a sleep specialist, which discusses how we're now treating sleep. We're widening airways in the mouth and the nose. That is better explained in the book with several very nice illustrations of people who have had excellent results with our products," he said.

He discussed innovative solutions for sleep-disordered breathing, including the eXciteOSA, the first FDA-authorized daytime treatment for mild obstructive sleep apnea.

Dr. Downs also emphasized the often-overlooked issue of sleep apnea in children, frequently misdiagnosed or co-occurring with ADHD.

"The last Cleveland study I read claimed about fifty percent of children were misdiagnosed with ADHD. In reality, they just had trouble sleeping or staying asleep because of undiagnosed obstructive sleep apnea. They're putting these children on drugs that may not be necessary. Our products help address sleep apnea, which can lead to those children not needing to remain on their ADHD medications," he said.

THE IMPACT OF MODERN LIFE ON AIRWAY HEALTH AND THE DENTAL SOLUTION

Drawing from his book, ‘Beautiful Faces,’ Dr. Downs elucidated how modern diets have contributed to underdeveloped jaws and compromised airways.

"My book, ‘Beautiful Faces: The Architects of Enhanced Attractiveness and Improved Human Breathing,’ addresses how our modern bodies and faces are not like they used to be. We're supposed to have a fuller lower jaw base and wider noses than we have. They have been progressively getting smaller as modern diets have changed and unhealthy eating habits have become more widespread," he shared.

Dr. Downs highlighted the role of orthodontics in airway management, advocating for creating space rather than extracting teeth.

"I also address getting clear aligner orthodontics in ‘Beautiful Faces.’ It used to be that

orthodontists would take out teeth and make less space, narrowing your mouth. We don't recommend that anymore, if it's at all possible. Now we know it’s best to widen the dental arches," he expounded.

He also explained how oral appliances can help widen the nasal airway, particularly in children. Dr. Downs said oral appliances that widen the upper dental arch can expand the nasal passages simultaneously. This is because the roof of the mouth (palate) forms the floor of the nasal cavity. By widening the upper arch, particularly in children, it's possible to achieve permanent widening of both the mouth and the nasal airway, improving breathing.

SLEEP BALANCE ACADEMY

Sleep Balance Academy is a health education and service platform founded by Dr. Richard Downs to help individuals identify and treat sleep-related breathing disorders, especially undiagnosed obstructive sleep apnea, that often go unnoticed in both dental and medical settings.

Dr. Downs created Sleep Balance Academy out of a conviction that poor sleep quality, disrupted breathing, and airway health issues are root causes of chronic disease, fatigue, premature aging, and even impaired facial development. After years of clinical observation, he saw the need for a simple, accessible approach to home-based sleep screening, airway evaluation, and early intervention using dental and lifestyle therapies. You can learn more about the Sleep Balance Academy by visiting https://www.sleepbalanceacademy.com/.

A HOLISTIC APPROACH: LIFESTYLE, DIAGNOSIS, AND TREATMENT

Dr. Downs addressed the importance of lifestyle factors like weight loss in managing sleep apnea, but cautioned that it rarely provides a complete solution.

"We recommend a monitoring ring as a weight loss tool. What most people don’t know about weight loss is that losing weight can actually help improve your quality of sleep. However, it rarely gets you to the point where you don't need any other treatment," he said.

He emphasized the necessity of proper diagnosis through a sleep study, strongly advising against self-treatment. He advised against buying snoring remedies online based on selfdiagnosis, as well, warning that these products often don't work and could potentially worsen the underlying issue.

Dr. Downs outlined the process of obtaining a sleep study and emphasized the importance of a physician's prescription for insurance coverage. He also mentioned a convenient and affordable online option through onlinehomesleepstudy.com. This service includes a comprehensive evaluation and a prescription for various treatment modalities.

RECOGNITION FOR INNOVATION AND A VISION FOR A HEALTHIER FUTURE

Towards the conclusion of the conversation, Dr. Downs was informed of his nomination for TopDoctor Product of the Year by TopDoctor Magazine and the prestigious "Blind Faith" sculpture award, recognizing significant contributions to healthcare. The symbolism of the award resonated deeply with his patient-centered approach.

Dr. Richard Downs' journey, marked by a distinguished dental career and a pioneering spirit in developing innovative health solutions, stands as a powerful testament to the transformative potential of dedication, knowledge, and a genuine commitment to improving lives. His work with hypochlorous acid and his insights into dental sleep medicine position him as a true innovator in the pursuit of holistic well-being. Visit his website for more information at https:// www.usa-guard.com/.

"Ultimately," Dr. Downs concluded, "whether through the gentle yet powerful science of hypochlorous acid or the innovative expansion of our airways, the goal remains the same: to empower individuals to breathe easier, sleep soundly, and live healthier, more vibrant lives. The journey is ongoing, but the potential to transform well-being is immense, and dentistry is poised to be a leading force in this vital evolution."

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STRESS ITS EFFECT ON AGING AND

Aging is an inevitable process influenced by genetics, environment, and lifestyle factors. While some aspects of aging are beyond human control, research has shown that stress plays a significant role in accelerating aging at both cellular and physiological levels.

Stress can lead to unhealthy coping mechanisms such as poor diet, lack of exercise, smoking, and excessive alcohol consumption. These behaviors exacerbate health risks associated with aging, including obesity, hypertension, and cardiovascular diseases.

Chronic physical, emotional, or psychological stress contributes to premature aging, affecting overall health, cognitive function, and lifespan. Understanding how stress impacts aging can provide us with vital information on ways to mitigate its effects and promote longevity.

Not all stress is harmful; in fact, experiencing some stress is a natural part of life. Stress triggers the body’s “fight or flight” response, releasing stress hormones such as cortisol and adrenaline. While short-term stress can be beneficial, enhancing focus and reaction times, chronic stress leads to prolonged exposure to these hormones, negatively impacting various bodily systems.

One of the primary ways stress accelerates aging is through the shortening of telomeres, the protective caps at the ends of chromosomes. Telomeres naturally shorten as we age, but chronic stress hastens this process, leading to cellular dysfunction and increased susceptibility to age-related diseases such as cardiovascular disease, diabetes, and neurodegenerative disorders.

Stress and Its Impact on Aging

Prolonged exposure to stress accelerates the aging process. Understanding how stress contributes to aging is essential for developing strategies to manage it effectively and promote a healthier, longer life. So, what are the effects of stress on aging?

Skin Aging: Chronic stress affects skin health by increasing inflammation and reducing collagen production, leading to wrinkles, sagging, and a dull complexion. Collagen is the most abundant protein in the human body, playing a crucial role in maintaining the structural

integrity of various tissues, including skin, bones, muscles, tendons, and ligaments. It acts as a scaffold, providing strength and elasticity to the body’s connective tissues. Furthermore, stressinduced hormonal imbalances can contribute to acne and other dermatological issues. As a result, chronic stress can make us appear years older than our chronological age.

Weakens Immune System: Stress impairs immune factors, making individuals more susceptible to infections, chronic illnesses, and slower wound healing. Your immune system has white blood cells that fight off germs and infections. Chronic stress lowers the number of white blood cells, making it harder for your body to fight illnesses like colds, flu, and even more serious diseases.

Increases Inflammation: Stress causes your body to produce more inflammatory chemicals. While inflammation is a regular part of healing, too much of it over time can damage healthy cells and make you more vulnerable to chronic diseases like heart disease, diabetes, and arthritis.

Slows Healing: If you get a cut or an injury, your body needs to repair itself. When stress is high, your body takes longer to heal because the immune system isn’t working as efficiently.

More Frequent Illness: Because your immune system is weakened, you may find yourself getting sick more often and taking longer to recover from common illnesses.

Stress from Cardiovascular Health Issues: Contributes to high blood pressure, inflammation, and increased risk of heart disease, which are commonly associated with aging.

Metabolic Issues: Elevated cortisol levels can lead to weight gain, particularly around the abdomen, insulin resistance, and a higher risk of type 2 diabetes, conditions that are linked to aging.

Cognitive and Emotional Impact

Stress not only impacts our bodies physically but also our cognitive functions and emotional well-being. Chronic stress has a profound impact on both cognitive and emotional well-being, affecting memory, decision-making, and overall mental health. Prolonged stress exposure disrupts brain function, which is essential for memory, and the prefrontal cortex, which is responsible for reasoning and problem-solving. High levels of stress hormones, such as cortisol, can lead to difficulty concentrating, forgetfulness, and an increased risk of cognitive decline over time.

Emotionally, stress contributes to anxiety, depression, and mood swings by altering neurotransmitter levels in the brain, making it harder to regulate emotions effectively. Additionally, chronic stress can reduce resilience to everyday challenges, increasing feelings of overwhelm and emotional exhaustion. Managing stress through mindfulness, social support, and relaxation techniques is crucial for maintaining cognitive health and emotional balance.

Memory Decline: Have you ever noticed that when you’re under tremendous stress, you have difficulty remembering things or even focusing on the task at hand? Chronic stress has been linked to shrinkage of the hippocampus, a brain region critical for memory and learning. This

increases the risk of cognitive decline and even Alzheimer’s disease.

Mental Health Disorders: Prolonged stress is a major contributor to anxiety, depression, and mood disorders, which can affect overall well-being and quality of life as individuals age.

Sleep Disruptions: When our bodies are under stress, we experience difficulty relaxing or getting a good night’s rest. You feel like you’re up all night thinking and worrying about your problems, pressure at work, or family matters. Stress interferes with sleep patterns, leading to insomnia or poor sleep quality, which accelerates aging by impairing cellular repair and cognitive function.

The bottom line is that chronic stress weakens your body’s natural defenses, making it easier for illness to take hold and more complicated for you to stay healthy as you age. Managing stress through relaxation, exercise, and healthy habits can help keep your immune system strong.

How to Combat Stress-Induced Aging

While stress is unavoidable, adopting effective coping mechanisms can mitigate its aging effects. Studies have shown that regular mindfulness and meditation practices can improve concentration, lower blood pressure, and enhance overall well-being. By incorporating these techniques into our daily life, we can better manage stress, improve mental clarity, and promote a healthier, more balanced state of mind.

Mindfulness

Mindfulness is a powerful tool for reducing stress by promoting relaxation and emotional balance. This practice helps calm the mind, lowers cortisol levels, and reduces the body’s fight-or-flight response, which is often triggered by stress. Mindfulness encourages individuals to focus on the present moment without judgment, helping them become more aware of their thoughts and emotions without becoming overwhelmed by them.

You can incorporate mindfulness into your day in several ways, including deep breathing, mindful walking, gratitude journaling, gardening, tai chi, or even engaging in creative activities such as painting.

My personal favorite is mindful walking, sometimes referred to as walking meditation. During my daily walks, I completely disconnect from my phone and focus on my senses. This is a time to walk and take in the sounds of nature and the natural beauty of the world around me in silence, taking deep breaths and being present in the moment.

Meditation

This is another way to reduce stress, whether through deep breathing, guided visualization, or silent reflection, meditation fosters a sense of inner peace and enhances emotional resilience. If you’re new to meditation, be patient with yourself. Our minds are so accustomed to being active and prone to wandering that it’s challenging to sit still and quiet our minds. When I first tried meditation, I found it to be frustrating, but with practice, I am now able to relax and find my sense of calmness.

Physical Activity

Regular exercise or physical activity reduces cortisol levels, enhances mood, and promotes healthy aging by maintaining cardiovascular health and muscle strength. It can be overwhelming if you’re a beginner in the fitness world, but it doesn’t have to be. Start with a simple plan, a more balanced approach—a mix of light cardio and strength training, 3 to 5 times a week. Not a fan of the gym? No problem. You can work out from home by doing body weight exercises, like squats, lunges, and pushups. If you enjoy dancing, consider joining one of the many group classes offered at your local gym or community center. It’s a great way to get your body moving while socializing to boost your mood.

Balance Diet

Ever heard the expression, “you are what you eat”? A balanced diet rich in antioxidants, omega-3 fatty acids, and essential vitamins supports cellular health and combats oxidative stress. Eating a balanced diet plays a crucial role in reducing stress by providing the body with essential nutrients that support brain function, regulate hormones, and improve overall well-being. Nutrient-rich foods help stabilize blood sugar levels, preventing energy crashes and mood swings that can exacerbate stress. For example, complex carbohydrates found in whole grains and vegetables promote the production of serotonin, a neurotransmitter that enhances mood and relaxation.

Not all fat contained in foods we eat is bad. Healthy fats, such as avocados, nuts, and fish, support brain health and reduce inflammation, which can be triggered by chronic stress. Additionally, consuming protein-rich foods helps maintain steady levels of neurotransmitters like dopamine and norepinephrine, which contribute to focus and resilience against stress.

Vitamins and minerals, such as magnesium (found in leafy greens and nuts) and B vitamins (found in eggs, meat, and legumes), play a vital role in calming the nervous system and reducing anxiety. Staying hydrated and avoiding excessive caffeine and sugar prevent jitters and energy crashes that can worsen stress. Maintaining a well-balanced diet can enhance the body’s ability to cope with stress, improve mood stability, and support long-term mental and physical health.

Social Interaction

Did you know that loneliness contributes to stress? Well, it does. People who live alone or are lonely tend to have higher stress levels. Loneliness significantly contributes to stress and exacerbates the aging process. When people experience chronic loneliness, their bodies respond by increasing stress hormone levels, particularly cortisol, which can lead to inflammation, weakened immune function, and higher risks of chronic diseases such as heart disease and hypertension.

As human beings, we are made to be inherently social creatures. We are meant to live and interact with others and create social bonds, but what happens when we don’t have human connections with others? Social isolation can negatively impact mental health, increasing the likelihood of anxiety, depression, and cognitive decline. Additionally, the absence of meaningful social interaction can lead to poor lifestyle habits, such as unhealthy eating, lack of exercise, and disrupted sleep, further exacerbating stress and aging.

On the other hand, strong social connections, whether through family, friendships, or community

involvement, can help buffer against stress, promote emotional resilience, and contribute to overall longevity. Engaging in social activities, practicing gratitude, and fostering meaningful relationships can help counteract loneliness's adverse effects on stress and aging.

Good Night’s Rest

We spend about 1/3 of our lives sleeping, but it’s still something many people struggle with. Many of us are sleep deprived, surviving on maybe four to five hours of sleep. Others suffer from chronic insomnia. Prioritizing good sleep hygiene allows the body to repair itself. Getting quality sleep counteracts the effects of stress and promotes healthy aging.

Incorporating these habits into your routine can improve your sleep quality, reduce stress, and enhance your overall well-being.

Maintain a Consistent Sleep Schedule: Go to bed and wake up at the same time every day, even on the weekends, to regulate your body’s internal clock. You can’t catch up on the sleep you lost.

Create a Relaxing Bedtime Routine: Engage in calming activities before bed, such as reading, listening to soothing music, or taking a warm bath, to signal your body that it’s time to sleep.

Limit Screen Time Before Bed: Avoid phones, tablets, and computers at least an hour before sleep, as the blue light from the screen can disrupt melatonin production, making it harder to fall asleep.

Enhance Your Sleep Setting: Keep your bedroom cool, dark, and quiet. Use blackout curtains or shades, a white noise machine, or an eye mask if necessary.

Avoid Caffeine and Heavy Meals Late in the Day: Limit caffeine intake in the afternoon and avoid large, heavy meals before bedtime, as they can interfere with sleep quality.

Avoid Exercise Late at Night: Engaging in regular physical activity during the day is excellent, but try to finish intense workouts a few hours before bedtime to allow your body to wind down.

Limit Alcohol and Nicotine: While alcohol may initially make you drowsy, it can disrupt sleep later in the night. Nicotine is a stimulant that can make it harder to fall asleep.

Practice Relaxation Techniques: Try deep breathing, meditation, or progressive muscle relaxation to calm your mind and prepare for restful sleep.

Use Your Bed Only for Sleep and Rest: Avoid working, watching TV, or using electronic devices to strengthen the mental association between your bed and sleep. This one may strike a chord with some of you, but heed my advice if your goal is a good night’s sleep.

Get Natural Light Exposure: Spend time outside in natural daylight, especially in the morning, to help regulate your sleep-wake cycle. Vitamin D will be beneficial for you.

Conclusion

Stress is a silent accelerator of aging, impacting physical and mental health. By understanding its effects and implementing lifestyle changes, individuals can slow aging and improve their overall quality of life. We all want to live longer, healthier, and more fulfilling lives. Individuals can promote healthy aging and longevity by understanding the connection between stress and aging and then incorporating stress management techniques such as prioritizing self-care and leading a balanced lifestyle.

WHERE SPIRIT LEADS AND SCIENCE ELEVATES

ULTIMATE WELLNESS™ CONFERENCE RETURNS TO THE ICONIC FAENA FORUM IN MIAMI BEACH ON SEPT 26–28, 2025

“At Ultimate Wellness™, we begin with the spirit—honoring ancient healing wisdom while integrating the latest innovations in longevity science to create a truly holistic wellness experience,” said Julia Smila, visionary founder of the movement that’s redefining health for the modern age.

Back by popular demand, the Ultimate Wellness™ Conference returns to the iconic Faena Forum in Miami Beach from September 26 to 28, 2025. This extraordinary gathering of longevity leaders, spiritual guides, innovators in biotech and health tech, and wellness seekers

is more than a conference—it’s a full-spectrum immersion into holistic health and peak performance, driven by purpose.

Learn more: https://www.ultimatewellness.miami/forum

Longevity science is expanding rapidly, fueled by breakthroughs in biotechnology, artificial intelligence (AI), advanced diagnostics, and cutting-edge biohacking strategies. Researchers can now map the aging process at the molecular level—using genomic sequencing, epigenetic analysis, and biomarker tracking to detect early signs of disease and biological decline, often years before symptoms appear.

At Ultimate Wellness™, we are proud to be at the forefront of this movement, shifting the paradigm from reactive care to proactive, precision-guided longevity. Our expo showcases carefully selected, scientifically validated technologies designed to empower individuals in their pursuit of optimal health and extended vitality.

And yet, even with all this scientific advancement, one fundamental question remains: Longevity for what purpose?

If the spiritual layer is missing, we risk extending lifespan without expanding soul-span. Longevity becomes meaningful only when grounded in love, purpose, connection, and contribution. A 100-year life fueled by fear of death is not the same as one guided by joy, reverence, and deep inner peace.

Research supports this: spiritual well-being is correlated with lower mortality, better cardiovascular outcomes, and healthier lifestyle choices.

We see this connection clearly in the world’s Blue Zones—regions where people live significantly longer, healthier lives. What sets them apart isn’t only diet or activity levels, but deeply integrated spiritual and social practices. From Okinawa to Sardinia, elements such as purpose, spiritual community, rituals, and intergenerational care are at the heart of longevity.

The Ultimate Wellness™ Conference is a global destination where ancient healing meets modern innovation to shape a new vision for holistic longevity.

Held at the architecturally stunning Faena Forum—part of the Faena Hotel Miami Beach resort, widely recognized as Florida’s premier luxury spiritual destination—this venue elevates every moment with light, elegance, and intention.

WHAT TO EXPECT: A TRANSFORMATIVE WEEKEND

• 50+ Expert Speakers delivering keynotes and panel discussions on topics including reversing biological age, regenerative medicine, metabolic and hormonal balance, mental resilience, cellular health, the gut-brain connection, detox strategies, and more.

• 35+ Pioneering Exhibitors showcasing cutting-edge biotech, health tech, and ecoconscious products.

• 10+ Immersive Wellness Experiences and Workshops—from spiritual meditation and DNA awakening to sound healing and Qigong.

• 1,500+ Attendees will include scientists, holistic and functional medicine doctors, regenerative medicine experts, healers, spiritual teachers, wellness entrepreneurs, and conscious consumers.

SPOTLIGHT SESSIONS ON THE MAIN STAGE

Explore leading-edge ideas from the biggest names in wellness and longevity:

• "Biohacking Consciousness" – Dr. Kien Vuu

• "Meditation Reinvented" – Dr. Patrick Porter

• "Quantum Tech & Frequency Medicine" – Philipp Samor

• "Harnessing Healing Technologies" – Robby Besner

• "Biohacking and Beyond" – Leila Centner

• "Optimize Your Mouth, Optimize Your Health" – Maya Assi

• "Deuterium Depletion" – Victor Sagalovsky

• "Built to Last" – JJ Virgin

• "Sexual Optimization" – Dr. Amy B. Killen

• "Menopause, Hormones & the Microbiome" – Cynthia Thurlow, NP

• "Female Longevity and Lifestyle" – Dr. Vonda Wright

• "Bioregulators and Beyond" – Nathalie Niddam

WOMEN'S HEALTH TRACK: SUNDAY, SEPTEMBER 28

This year’s conference will include a full Women’s Health Track, featuring the signature panel: “She Who Heals: Bridging Ancient Wisdom and Modern Science for Radical Self-Care.”

Explore how women can thrive through perimenopause, menopause, and beyond. Can’t attend Friday or Saturday? A Sunday Pass is available.

Full agenda: https://www.ultimatewellness.miami/forum/agenda

BREAKTHROUGH BRANDS FEATURED AT THE EXPO

A sample of the 35+ companies shaping the future of wellness:

• Leela Quantum Tech – Natural energy wellness products

• BrainTap – Neurotechnology for cognitive enhancement

• Centner Wellness – Fusion of healing traditions and tech

• TruDiagnostic – Epigenetic testing and longevity research

• Litewater Scientific – Deuterium-depleted water

• CODE Health – Advanced therapeutic solutions

• Blushield – EMF protection technology

• Alpha Dental Practice & Implant Center – Integrative dental innovation

• Zero Gravity – Aesthetic anti-aging devices

• GutID – AI-powered microbiome analysis

• Iyashi DÔme – Infrared detox and recovery

• Therasage – Infrared healing devices

• NeuX – Physical and cognitive performance platform

• Aqua Cure - Biohacking skincare solutions

• BTT Brain Cooling Device - Non-invasive brain optimization

• Atlas Clinics - Upper cervical care

• KLOUD by Centropix - High-intensity frequency therapy

• Everyday Dose - Mushroom-based coffee alternatives

• Ascended Health - Scalar-infused botanicals

... and many more

Explore all exhibitors: https://www.ultimatewellness.miami/forum/expo

IMMERSIVE WELLNESS EXPERIENCES

This isn’t just about learning—it’s about embodiment and awakening. Experience:

• Twin Hearts Meditation – with Agustina Caminos

• Transformative Breathwork – with Daniel Silva

• Sound Healing – with Jared Bistrong & South Beach Sound Healing Orchestra

• DNA Awakening Meditation – with Sitara

• Kama Flight – Aerial healing movement

More experiences here: https://www.ultimatewellness.miami/forum/experiences

THE ULTIMATE VIP GATHERING OF 2025

The first-ever Lifespanning Award Ceremony will take place on Friday, September 26. Join us in honoring leaders advancing biotechnology, human optimization, and health tech. An exclusive VIP Dinner follows for networking and celebration.

VIP ticket includes:

• Full access to all conference events

• Admission to the Awards Ceremony & Dinner

• VIP Lounge access with complimentary IVs

• Premium Swag Bag with high-value wellness products

Tickets are limited: Reserve your VIP seat: https://www.ultimatewellness.miami/forum

A FAMILY-FRIENDLY WELLNESS RETREAT

The Ultimate Wellness™ Conference is also a family-friendly event. Our Kids Lounge, powered by Centner Academy, offers meaningful, educational activities for children while parents engage in the event.

Attendees will reconnect with their higher self through spiritual activations, ancient rituals, and transformative workshops designed to align mind, body, and soul.

RESERVE YOUR PLACE TODAY

This isn’t just another health event—it’s the ultimate experience in conscious living, science-based transformation, and soul-centered connection.

Use promo code TopDoctor for a special rate.

Reserve now: https://www.ultimatewellness.miami/forum

ABOUT THE FOUNDER

Julia Smila is the founder of Ultimate Wellness™, a Functional Diagnostic Nutrition Practitioner, Pranic Healer, Arhatic Yoga practitioner, and longevity expert. She integrates spiritual insight with cutting-edge health science to help others thrive.

With a background in venture capital—supporting biotech and health tech startups—Julia now focuses on merging ancient healing traditions with modern wellness strategies. She is the host of the annual Ultimate Wellness™ Conference and is cultivating a heart-centered, spiritually aligned global community.

Julia lives in Miami Beach with her daughter Alexa, who shares her passion for holistic health and wellness.

Meet Julia: https://www.ultimatewellness.miami

Join us in Miami Beach, where the future of health begins with the heart, honors the past, and embraces limitless living.

AGELESS TIMELESS

THERAPIES

DR. JOSEPH PURITA INTERVIEWED

BY

MICHELE HUGHES OF AGELESS AND TIMELESS AND OPTIMIZING HEALTH TH ROUGH REGENERATIVE

CEO Ageless and Timeless and host of the Ageless and Timeless podcast

WHAT INSPIRED YOU TO SPECIALIZE IN REGENERATIVE MEDICINE?

Early in my career as an orthopedic surgeon, I became fascinated with the body’s ability to heal itself. Traditional medicine often focuses on symptom management rather than true healing. Regenerative medicine offered an entirely different approach—one that enhances the body’s natural repair mechanisms. I saw firsthand how PRP, stem cell therapy, and other biologics could transform patient outcomes, and I knew this was the future of medicine.

HOW DID YOU FIRST GET INVOLVED WITH EBO2 THERAPY, AND WHAT DREW YOU TO THIS INNOVATIVE TREATMENT?

I got involved through a colleague in the Dominican Republic who was treating major league baseball players. I’ve always been drawn to therapies that enhance cellular function at the deepest level. EBO2 intrigued me because it optimizes oxygen utilization, removes toxins, and enhances immune function all at once. I started integrating it into my practice after seeing its incredible potential in improving vascular health, reducing inflammation, and enhancing recovery. Over time, I’ve refined its applications and combined it with other regenerative therapies to maximize its benefits.

CAN YOU EXPLAIN HOW EBO2 THERAPY WORKS AND HOW IT DIFFERS FROM TRADITIONAL OZONE THERAPY?

EBO2, or Extracorporeal Blood Oxygenation and Ozonation, is an advanced form of ozone therapy that goes beyond traditional methods. Unlike standard ozone therapy, which typically involves injecting or infusing ozone into the body, EBO2 filters the blood through a dialysis-like system, removing inflammatory proteins, heavy metals, and toxins while super-oxygenating the blood.

A key distinction is that no ozone directly enters the body. Instead, the blood and ozone mix within the dialysis filter, where the ozone is converted into beneficial compounds. This process enhances circulation, reduces inflammation, and supports immune function at a systemic level.

WHAT CONDITIONS OR DISEASES RESPOND BEST TO EBO2 THERAPY?

EBO2 is highly effective for conditions linked to chronic inflammation, poor circulation, and immune dysfunction. This includes cardiovascular disease, autoimmune disorders, Lyme disease, chronic fatigue syndrome, mold toxicity, and even neurodegenerative conditions. Athletes and biohackers also use it to optimize recovery and performance, as well as slow down the aging process.

ARE THERE ANY PARTICULAR PATIENT SUCCESS STORIES THAT STAND OUT IN YOUR EXPERIENCE WITH EBO2?

Absolutely. I’ve treated patients with chronic fatigue and autoimmune diseases who, after just a few sessions, experienced significant improvements in energy levels, cognitive function, and overall well-being. One patient with severe Lyme disease had tried nearly everything without success, but after undergoing EBO2 therapy, their symptoms improved dramatically. The ability of this therapy to restore health at a cellular level is truly remarkable.

HOW DOES EBO2 THERAPY COMPARE TO OTHER REGENERATIVE TREATMENTS LIKE STEM CELLS AND PRP (PLATELET-RICH PLASMA)?

EBO2 complements other regenerative therapies rather than replacing them. Stem cell therapy and PRP focus on tissue repair and regeneration, while EBO2 works at the systemic level to optimize cellular function, detoxify the body, and enhance circulation. They create a powerful synergy that accelerates healing and recovery when used together.

WHAT RECENT ADVANCEMENTS IN REGENERATIVE MEDICINE ARE YOU MOST EXCITED ABOUT?

One of the most exciting advancements is plasmapheresis, a cutting-edge therapy that helps reset the body at a cellular level by filtering and rejuvenating the blood. This process removes inflammatory proteins, toxins, and aged plasma components while replenishing the body with healthier plasma. It’s particularly promising in addressing age-related diseases, autoimmune conditions, and chronic inflammation.

Plasmapheresis is gaining traction as a powerful tool for longevity and regenerative medicine because it essentially “cleanses” the bloodstream, allowing cells to function more efficiently. When combined with other regenerative therapies like EBO2, stem cells, and peptides, it creates a comprehensive approach to cellular rejuvenation and optimal health. As research continues, I believe plasmapheresis will play a pivotal role in extending healthspan and improving recovery from chronic conditions.

HOW DO YOU ENSURE THE SAFETY AND EFFICACY OF EBO2 THERAPY FOR YOUR PATIENTS?

Patient safety is our highest priority. We utilize medical-grade ozone in precise, controlled doses, ensuring all treatments are conducted in a sterile, medically supervised environment under strict protocols. Each patient undergoes thorough screening to determine suitability, and we closely monitor their response to optimize therapy outcomes.

Beyond our own practice, we are leaders in EBO2 education and training, instructing medical professionals across the United States, the Caribbean, Europe, and Turkey. By establishing and upholding the highest standards in EBO2 therapy, we are shaping the future of this advanced treatment worldwide.

ARE THERE ANY MISCONCEPTIONS ABOUT EBO2 THERAPY THAT YOU’D LIKE TO ADDRESS?

One common misconception is the confusion between EBO2 and EBOO—many assume they are the same, but EBO2 is a more advanced and effective version of the therapy. While both involve extracorporeal blood oxygenation and ozonation, EBO2 offers several key advantages.

EBO2 uses a higher dose of ozone, allowing for greater oxygenation and detoxification benefits. It also filters a larger volume of blood, helping to remove more inflammatory

proteins, heavy metals, and other toxins. Additionally, EBO2 incorporates a more effective light device, enhancing blood purification and optimizing cellular function far beyond what standard EBOO systems achieve.

Another misconception is that ozone therapy is unsafe. When administered correctly in a controlled setting, EBO2 is a powerful, research-backed therapy that enhances immune function, reduces chronic inflammation, and supports overall longevity.

WHERE DO YOU SEE THE FIELD OF REGENERATIVE MEDICINE HEADING IN THE NEXT 5-10 YEARS?

Regenerative medicine will continue to shift from isolated treatments to a more holistic, systems-based approach. We’ll see more personalized therapies based on genetic and epigenetic profiling, allowing for highly targeted interventions. Integrating AI and machine learning will also enhance diagnostic accuracy and treatment efficacy.

ARE THERE ANY UPCOMING BREAKTHROUGHS OR TECHNOLOGIES THAT YOU BELIEVE WILL REVOLUTIONIZE THIS SPACE?

AI and CRISPR are transforming regenerative medicine. AI enables precision diagnostics and personalized treatment plans, optimizing therapies like stem cells and EBO2 for each patient. CRISPR gene-editing technology allows for DNA modifications, correcting mutations, enhancing cellular repair, and potentially reversing aging. Together, these advancements are shifting medicine from reactive treatments to proactive health optimization, paving the way for longer, healthier lives.

WHAT ADVICE WOULD YOU GIVE TO DOCTORS LOOKING TO INCORPORATE REGENERATIVE THERAPIES LIKE EBO2 INTO THEIR PRACTICE?

Start with a strong foundation in the science behind these therapies. Seek training from experts in the field, stay updated on the latest research, and integrate regenerative medicine in a way that complements existing treatments. Most importantly, focus on patient education—helping them understand how these therapies work will lead to better compliance and outcomes.

WHAT CHALLENGES HAVE YOU FACED IN PROMOTING REGENERATIVE MEDICINE, AND HOW HAVE YOU OVERCOME THEM?

One of the biggest challenges has been overcoming skepticism. Regenerative medicine often faces resistance because it challenges traditional medical paradigms. I’ve tackled this by focusing on education—lecturing globally, publishing research, and sharing real-world success stories. As more clinical evidence emerges, the acceptance of these therapies continues to grow.

HOW DO YOU BALANCE SCIENTIFIC RIGOR WITH INNOVATIVE, CUTTING-EDGE TREATMENTS?

The key is to remain open to new ideas while maintaining a strong commitment to evidencebased medicine. I always evaluate new treatments through the lens of science, clinical experience, and patient outcomes. Innovation is essential, but it must be backed by data and a clear understanding of the underlying mechanisms.

ABOUT DR. JOSEPH PURITA

Dr. Joseph Purita is a board-certified orthopedic surgeon and a global regenerative medicine leader specializing in cellular and anti-aging therapies. With over 20 years of experience, he has pioneered advancements in Ozone Therapy and EBO2 (Extracorporeal Blood Oxygenation & Ozonation), lecturing worldwide on cutting-edge treatments.

As the inaugural president of the American Academy and Board of Regenerative Medicine, Dr. Purita has played a key role in shaping the field. He currently serves as the medical director of PUR-FORM and sits on multiple scientific boards. Recently appointed as a Professor of Regenerative Medicine at the University of Max Planck in Brazil, he continues to drive innovation in the field.

ABOUT MICHELE HUGHES

Michele Hughes is the visionary founder of Ageless and Timeless and the dynamic host of the Ageless and Timeless podcast. As a monthly contributor to Top Doctor Magazine, she offers powerful insights on wellness, longevity, and living fully at every stage of life. With a deep passion for health, vitality, and a role model for timeless elegance, Michele empowers audiences to embrace their highest potential and live with purpose and grace. Michele's podcast, Ageless and Timeless, was one of 20 Inaugural Podcasts selected for the Muscle and Fitness Plus platform that began in 2023.

For more information, please reach out to express interest in being a potential guest on the Ageless and Timeless podcast or to be featured in the Top Doctor Magazine Ageless and Timeless column with Michele Hughes. For podcast collaborations or to have Michele Hughes on your show, please contact her at:

Email: themichelehughescompany@gmail.com

Website: www.agelessandtimeless.com

Instagram: @agelessandimeless

LinkedIn: https://www.linkedin.com/in/michele-hughes-83a3b935/

Facebook: https://www.facebook.com/michele.hughes.186

Ageless and Timeless podcast, on YouTube, iTunes, Spotify, and wherever podcasts are available.

REFERENCES AND RESOURCES

HONORING THE RESILIENCE OF CANCER SURVIVORS IN NATIONAL CANCER SURVIVOR MONTH

You can find more from Evelyn through her website or social media channels:

1. Website: EvelynFlaharty.com

2. YouTube: Evelyn Flaharty

3. YouTube: Workouts With Evelyn Flaharty

4. Instagram: ffmusclesandcurves

5. TikTok: @evelynifbbpro

6. Facebook: Evelyn Flaharty

TRAUMA IN THE WOMB AND EPIGENETICS

1. To learn more about events and retreats, or to schedule a call with Ocean Eagle, visit https://linktr. ee/oceaneagle1.

UNLOCKING HUMAN POTENTIAL:

A CONVERSATION WITH MICK SAFRON, CEO & FOUNDER OF THE BIOHACKERS WORLD CONFERENCE & EXPO

Join us at the Biohackers World Conference & Expo, taking place July 26–27, 2025, in Chicago, IL.

Tickets are available now at https://www.biohackers.world.

For more information, please reach out to express interest in being a potential guest on the Ageless and Timeless podcast or to be featured in the Top Doctor Magazine Ageless and Timeless column with Michele Hughes. For podcast collaborations or to have Michele Hughes on your show, please contact her at:

1. Email: themichelehughescompany@gmail.com

2. Website: www.agelessandtimeless.com

3. Instagram: @agelessandimeless

4. LinkedIn: https://www.linkedin.com/in/michele-hughes-83a3b935/

5. Facebook: https://www.facebook.com/michele.hughes.186

6. Ageless and Timeless podcast, on YouTube, iTunes, Spotify, and wherever podcasts are available.

DR. RICHARD DOWNS: A PIONEER IN DENTAL SLEEP MEDICINE AND THE REVOLUTIONARY POWER OF HYPOCHLOROUS ACID

1. Visit the OraCare website for more information at https://www.hyponasal.com/.

2. You can learn more about the Sleep Balance Academy by visiting https://www.sleepbalanceacademy. com/.

3. Read Beautiful Faces: The Architects of Enhanced Attractiveness and Improved Human Breathing through the link.

STRESS AND ITS EFFECT ON AGING

1. Discover articles from Evelyn and other contributing authors by visiting our website at topdoctormagazine.com.

WHERE SPIRIT LEADS AND SCIENCE ELEVATES:

THE ULTIMATE WELLNESS™ CONFERENCE RETURNS TO THE ICONIC FAENA FORUM IN MIAMI BEACH ON SEPTEMBER 26–28, 2025

1. Learn more: https://www.ultimatewellness.miami/forum

OPTIMIZING HEALTH THROUGH REGENERATIVE THERAPIES — DR. JOSEPH PURITA INTERVIEWED

BY MICHELE HUGHES OF AGELESS AND TIMELESS

Discover more about Dr. Purita and the Regenerative Medicine Training Institute by visiting https://www.rmtinstitute.com/online-curriculum/dr-joseph-purita-institute-of-regenerative-medicine.

For more information, please reach out to express interest in being a potential guest on the Ageless and Timeless podcast or to be featured in the Top Doctor Magazine Ageless and Timeless column with Michele Hughes. For podcast collaborations or to have Michele Hughes on your show, please contact her at:

1. Email: themichelehughescompany@gmail.com

2. Website: www.agelessandtimeless.com

3. Instagram: @agelessandimeless

4. LinkedIn: https://www.linkedin.com/in/michele-hughes-83a3b935/

5. Facebook: https://www.facebook.com/michele.hughes.186

6. Ageless and Timeless podcast, on YouTube, iTunes, Spotify, and wherever podcasts are available.

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