As the soft bloom of spring begins to awaken the world around us, I invite you to pause and breathe in the energy of renewal
This season reminds us that life is cyclical, fertile, and full of promise At The DNA Talks Digest, we believe that true wellness begins from within and that every woman deserves the knowledge and power to nurture her own rebirth, in body, mind, and spirit
That’s why I’m so proud to introduce this spring’s She Summit a transformative, three half-day event bringing together key opinion leaders in women’s health, fertility, and sexual wellness. Grounded in functional genomics, this summit is more than just a conversation—it’s a catalyst for a much needed change in women’s health. We’re unearthing truths, elevating science, and restoring agency to women through knowledge that’s as personalized as their DNA.
Fertility isn’t only about the ability to conceive; it’s about what you are creating in your life. What seeds are you planting this spring? A new wellness routine? A healthier relationship with your body? A deeper understanding of your genetic code?
This edition, we are putting a special spotlight on infertility a journey that too many walk through in silence We will address the emotional toll it can take, the mental health stigma that still surrounds it, and the deep, often invisible pain that comes with longing, loss, and uncertainty You are not alone Through raw conversations, expert insight, and community, we aim to bring light, healing, and hope to this important dialogue
This is your season to rise
Let us walk beside you with insights, inspiration, and the tools to help you grow—vibrantly, confidently, and in alignment with your most powerful self.
With purpose and gratitude,
Tr FGP CEO & Founder
The
DNA
Talks Digest
“Where Functional Genomics Meets Feminine Power”
THOUGHT LEADERS DRIVING THE CONVERSATION
DR KRISTA KOSTROMAN, ND, BCS, CFGP
Chief Science Officer The DNA Company
CEO, The DNA Company & Founder of DNA University
DR LACHLAN CRAWFORD, ND, CFGP
Associate Dean The DNA University
Certified Functional Genomics Practitioner
DR
Dean of Students The DNA University
Certified Functional Genomics Practitioner
DR TIFFANY SMITH, DNP, APRN, PMHNP-BC, MASTER AROMATHERAPIST
Certified Functional Genomics Practitioner
JUSTIN HARRIS, CFGP
LYNN ANGEL, CFGP
TRACY WOOD, CPC, ELI-MP, HHA, CFGP
LARA VARDEN, PHD, BCHHP, LEHP, CFGP, CFNC
DR GABRIELLE GUTIERREZ, PHARMD , CFGP
FELICIA BRUNO Program Coordinator The DNA Company Director for Genomic Fitness The DNA Company
Each contributor brings their unique expertise, from cutting-edge research to practical applications in genomics, offering readers valuable insights into the future of healthcare. Together, this diverse roster of experts provides actionable knowledge to help individuals optimize their health.
CANDICE BARLEY
SUE NORDEMO, RN, CI ASW
JESSICA HALPERN, DIPHIR, CCI, INHC, API
DR. MANDEEP JOHAL, DMD
DR BETTY MURRAY PHD, MS, CN, IFMC
MYRIAM LLANO
Author, The Explant Book Founder of Olistico Life Monarch Health Coaching and Hypnosis
Functional Dentist Founder of H E A L
CEO & Founder of Living Well Dallas Functional Medicine Center
My Journey with Functional Genomics and Breast Implant Illness
I never imagined that I could unlock the secrets of my health, not through guesswork, but with a personalized blueprint unique to me. This became my reality when I discovered The DNA Company and ventured into the world of functional genomics with the DNA 360 test. Here’s my story of transformation and how a simple saliva test became the missing piece in my health journey
Born Out of Balance
My health struggles began even before birth My mother, bedridden with strep throat during her pregnancy, had to take antibiotics that disrupted the balance of my beneficial bacteria Born via Cesarean section, I missed out on the natural microbial transfer crucial for a robust immune system My childhood, marked by recurrent infections and undiagnosed food intolerances, hinted at underlying genetic vulnerabilities that would become clear 45 years later
My grandmother, a pioneer in holistic health, introduced me to probiotics, instilling a belief in the body's ability to heal with the right support Her home remedies were my first glimpse into the power of natural healing, a necessity given my genetic predisposition for an imbalanced gut microbiome
Middle School and Body Image
Ballet was my world until a move to a new school shifted everything Despite becoming one of the youngest members of the Professional Ballet Company, I struggled with my undeveloped body Middle school brought harsh comments about my physique leaving me feeling inadequate My body's
Looking for Answers and Facing Medical Gaslighting
By 2018, my health was in crisis. Doctors dismissed my symptoms, attributing them to motherhood. Desperate for answers and through a divine intervention, I discovered breast implant illness (BII). Despite medical skepticism, I trusted my instincts and scheduled explant surgery to remove my breast implants.
From Patient to Advocate
Post-surgery, my symptoms began to slowly resolve My liver function improved, and I regained my energy I began sharing my story, connecting with women facing similar struggles As a patient advocate, I help others navigate the journey I once faced alone I have now helped thousands of women and even wrote a book called The Explant Book as a guide through BII and explant surgery
As I continued to explore why my body struggled with implants and other issues, I found another breakthrough with The DNA Company Taking this saliva test was revelatory suddenly, my lifelong health challenges all made sense. All four of my main immune detox pathways, vitamin D, methylation, antioxidant, and glutathione, are genetically suboptimal. I discovered a genetic predisposition for impaired detoxification, gut microbiome imbalances, estrogen dominance, non-celiac gluten sensitivity, and even the reason I felt unwell after cardio compared to weightlifting Everything became crystal clear!
I no longer guess which supplements to take Understanding my genetics has allowed me to restore my health to unprecedented levels Although I can't change my genetics, I can optimize them to function as if they were perfect This test is something I wish every woman, man, and child knew existed
“ ”
NERDS’ NOOK: HEAR ME ROAR
By Dr Krista Kostroman, ND, BCS, CFGP, Chief Science Officer | The DNA Company
Recently, scientists have expressed concern over new language restrictions in federally funded research Prompted by an executive order and reinforced through written memos and verbal directives, the National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC) are now assessing research proposals and health communications for flagged keywords to identify potential violations These flagged terms include fundamental scientific concepts like inclusion and exclusion, as well as essential human descriptors such as women, race, ethnicity, and LGBTQ and clinical concerns like mental health and trauma. Notably, man is absent from the list. Grants and information deemed non-compliant may be subject to modification, partial funding cuts, or elimination. The agencies have not publicly disclosed their review processes. These unprecedented restrictions threaten the integrity of scientific inquiry by limiting researchers’ ability to describe reality accurately, categorize data effectively, and follow evidence without political interference
Blunted by Censorship
The risk is clear: when science gets skewed or silenced, society misses out on valuable knowledge and innovations as a result When studies that include basic demographic information risk falling under censorship policies, researchers face uncertainty about what is permissible and how much critical information and perspective must be omitted to comply This distorts data collection and reporting, altering how knowledge is recorded, categorized, and shared with potentially severe consequences (two such examples are explored below).
The scientific community fears that these language restrictions will harm data integrity and limit funding in crucial areas If researchers cannot use terms like women, race, or trauma, they may be unable to accurately describe who is affected by a disease or health trend Words matter in science As one public health scientist noted, “If I can’t say the word women, I can’t tell you that an abortion ban is going to hurt women If I can’t say race and ethnicity, I can’t tell you that Hispanic communities are experiencing higher rates of a particular disease ” In other words, banning specific words prevents scientists from accurately describing the world, making it harder to address real problems
Additionally, the need to continually edit research to comply with restrictive policies can cause delays or even lead to the abandonment of important studies Some warn that such an environment may drive scientists away, resulting in a migration to countries without censorship policies, contributing to an American brain drain While the long-term effects of these policies remain unclear, the risks to scientific progress and innovation are substantial Let us explore why scientific liberty and accurate categorization of data are so critical
Misdiagnosis of Heart Attacks in Women
A key example of the importance of unbiased research is the history of heart disease treatment in women. For decades, cardiovascular research and diagnostic criteria were based mostly on studies of men, under the assumption that heart attacks presented similarly in all individuals. This flawed view had serious consequences for women
Women often experience different heart attack symptoms than men, such as nausea or fatigue rather than the classic chest pain Because early research focused on male patients, these atypical symptoms were frequently overlooked or misinterpreted As a result, women were 50% more likely than men to be misdiagnosed when experiencing a heart attack, leading to higher mortality rates due to delayed or incorrect treatment
These findings, as well as inclusive funding policies, prompted the medical community to change its approach Research in the early 2000s advocated for sex-specific clinical trials and guidelines, revealing crucial differences in how heart disease develops in women For example, women are less likely to receive certain diagnostic tests and treatments unless physicians know what to look for
This underscores the importance of scientific independence. If researchers ignore or downplay sex and gender differences, vital information is lost The misdiagnosis of heart attacks in women serves as a cautionary tale: science must be empowered to explore differences and question assumptions, or entire populations may be left at risk
Genetic Research Across Racial Groups
Another example highlighting the need for careful and inclusive scientific language comes from genetic research and personalized medicine With awareness race is a social construct and its impact and nuance yet to be fully appreciated in genetics, we’ve learned that who gets studied greatly influences what conclusions can be drawn. Genetic studies in past decades have not adequately represented the world’s racial and ethnic diversity. While this is changing, up until recently about 80% of participants in genomic research have been of European ancestry, even though Europe and its diaspora account for only about 16% of the global population.
This imbalance means that medical tools and risk calculators developed from these studies may be less effective for individuals from underrepresented groups For example, heart disease or diabetes risk calculators based on largely European datasets can be inaccurate for people of other backgrounds Important genetic markers may be overlooked in minority populations, leading to misdiagnoses or ineffective treatments, thereby widening health disparities
cou ag g d e s y esea c pa c pa s a d e g da a categorization improves the validity of findings However, this can only happen if research policies allow for honest discussions of race, ethnicity, and genetic variation
Empowered by Liberty
Both the historical biases in heart disease research and the gaps in genomic data highlight why scientific progress depends on freedom of inquiry and precise language When politics or fear prevent scientists from using terms like women or race, reality does not change only the ability to address critical issues does Liberty of language in research is essential Scientists must be able to name and analyze differences, whether identifying vulnerable populations or acknowledging variations among groups This transparency allows researchers to recognize problems such as misdiagnosed heart attacks or ineffective treatments and develop solutions that benefit everyone
The best scientific outcomes come from maintaining the independence and integrity of research. This means protecting scientists’ ability to gather data objectively, categorize it appropriately, and follow the evidence to logical conclusions. It also means encouraging diversity in research including diverse study participants, methodologies, and ideas so that findings are robust and applicable to all people. Science must be allowed to evolve based on evidence rather than being restricted by political constraints
By safeguarding scientific liberty, we empower experts to speak the truth about our world, even when it is complex or inconvenient
3
the Negative Results section J Cereb Blood Flow Metab 2010;30(7):1263-1264 doi:10 1038/jcbfm 2010 51 Gupta A Fraud and misconduct in clinical research: A concern Perspect Clin Res 2013;4(2):144-147 doi:10 4103/2229-3485 111800
4 Living With: a Family Member With Dementia. (n.d.). PsychGuides. Retrieved June 23, 2014, from http://www.psychguides.com/guides/living-with-a-familymember-with-dementia/.
Ioannidis JP Why most published research findings are false [published correction appears in PLoS Med 2022 Aug 25;19(8):e1004085 doi: 10 1371/journal pmed 1004085 ] PLoS Med 2005;2(8):e124 doi:10 1371/journal pmed 0020124
5. Prasad K. Publication bias perpetuates use of ineffective drugs in stroke. Int J Stroke. 2009;4(3):183-184. doi:10 1111/j 1747-4949 2009 00279 x
6. Responsible conduct of research: Conflicts of interest (n d ) Columbia University, Columbia Center for New Media Teaching and Learning Retrieved June 23, 2014, from http://ccnmtl columbia edu/projects/rcr/rcr conflicts/foundati on/
8
7 Reynolds T Eliminating publication bias: the effect of negative trial results J Natl Cancer Inst 2000;92(9):682 doi:10 1093/jnci/92 9 682
THE HEARTBREAK AND HOPE OF INFERTILITY: HOW GENETICS PLAY A ROLE
By Dr. Lara Varden, PhD, BCHHP, LEHP, CFGP, CFNC | The DNA Company
What can be more heartbreaking than desperately wanting a child but being unable to conceive? Or going through the joy of a positive pregnancy test only to lose the baby within the first trimester again and again? Not once, not twice, but four times This painful reality has touched the lives of so many women, including my own daughter
Another dear friend struggled with severe endometriosis and underwent multiple rounds of in vitro fertilization (IVF), spending thousands of dollars in the hopes of conceiving Yet another client of mine spent years trying, investing tens of thousands of dollars to fulfill the dream of holding a beautiful baby in her arms
But here’s the wonderful part these three women, despite their struggles, were able to have children Two of them had successful pregnancies through IVF, and my daughter, after years of heartbreak, is now 20 weeks pregnant with my grandson conceived naturally
So why is infertility becoming more common? Why are so many women struggling to conceive or maintain a pregnancy? Unfortunately, increased toxin exposure, nutrient deficiencies, and stress have a significant impact on the expression of our genes That’s why understanding our genetic makeup is so important Identifying genetic vulnerabilities allows us to take targeted steps to support fertility and increase the chances of a successful pregnancy
Many genes influence reproductive health, affecting hormone levels, egg and sperm quality, and the body's ability to detoxify harmful substances Below are some crucial genes that may contribute to infertility.
The Methylation Pathway is how our bodies make methyl groups and plays a critical role in folate metabolism, a process vital for DNA synthesis and repair Methyl groups are required for nucleotide synthesis in a developing baby [1], among other critical functions including detoxification
Variants in MTHFR, for example, like C677T and A1298C can reduce enzyme efficiency and along with variants in the MTR and MTRR genes, can lead to high homocysteine levels, which have been linked to recurrent pregnancy loss and male infertility [2,3]. The MTHFR C677T variant can affect IVF success rates, with women carrying two copies (TT genotype) facing more than double the risk of recurrent implantation failure and having fewer transferable embryos [4,5].
Women with MTHFR mutations often require higher folate and cobalamin intake along with the other B vitamins to support a healthy pregnancy Leafy green vegetables and legumes are wonderful sources of folate, and beef liver packs a ton of folate along with vitamin B12 If you are going to take supplements, be sure to check your SHMT1 and MTR genes to see which form of folate and cobalamin (B12) you should use, whether it’s the methylated or adenylated form
I intentionally use the term folate rather than folic acid because folic acid is a synthetic form of folate commonly found in fortified foods and many vitamin supplements in the United States However, for women with the MTHFR C677T mutation, excess folic acid may be harmful, as unmetabolized folic acid can accumulate and potentially cause adverse effects [6] If you are taking prenatal supplements, check the ingredient list and consult your fertility specialist if you have concerns
Methylfolate, the active form of folate, bypasses the need for the MTHFR enzyme, making it a more efficient option for those with this mutation Research on women undergoing infertility treatment found that those who took a B-complex with methylfolate had higher pregnancy and birth rates compared to those taking folic acid supplements [7]
Vitamin D, which is really a hormone, plays a vital role in sex hormone regulation and reproductive health There are three main genes we look at in our DNA360 reports for the vitamin D pathway, CYP2R1, GC/VDBP, and VDR Variations in these genes can lead to lower vitamin D levels and decreased availability and utilization of this vital hormone, which has been linked to infertility, polycystic ovary syndrome (PCOS), poor embryo implantation, and preeclampsia [8,9].
In the sex hormones pathway, CYP17A1 is essential for producing androgens, the precursors of sex hormones Overactive CYP17A1 variants may increase androgen levels, which can contribute to PCOS in women and potential sperm production issues in men [3] The CYP19A1 (aromatase) gene is responsible for converting testosterone into estrogen Variations in CYP19A1 have also been associated with PCOS, a condition that leads to irregular ovulation and infertility [3]
FOXO3, most notably associated with metabolism, protein stability, and aging, is a key regulator of the ovarian reserve [10] Mutations in FOXO3 can lead to premature ovarian failure, significantly reducing a woman’s egg supply and increasing the risk of early menopause [11]
Brain-derived neurotrophic factor (BDNF) is critical for follicle development in the ovaries A common variant (A allele) has been linked to an increased risk of endometriosis, a condition that can cause infertility and poor IVF success rates [12]
SOD2 protects reproductive cells from oxidative stress, which can harm sperm and egg quality Women with the CC allele of SOD2 have shown higher success rates with IVF, likely due to better mitochondrial function [13]
If infertility has impacted your life, you are not alone The genetic factors discussed above play a crucial role, but they do not determine your fate By understanding your genetics and making targeted lifestyle changes, you can take proactive steps toward improving your fertility.
Small but meaningful changes can make a big difference:
Optimize nutrition: Supporting methylation with active folate (5-MTHF), vitamin B12, vitamin D, and antioxidants can reduce genetic risks
Reduce toxin exposure: Avoiding endocrine disruptors, processed foods, and environmental toxins can ease the burden on detoxification pathways
Manage stress: Chronic stress suppresses reproductive hormones Practicing relaxation techniques such as meditation or acupuncture can help
Seek genetic testing: If you’ve struggled with infertility, genetic testing can provide valuable insights into potential underlying causes and guide a personalized plan
You are more than your genetics While your DNA provides a blueprint, it is your choices and actions that bring it to life Whether through lifestyle modifications, medical advancements, or sheer perseverance, your journey to parenthood is still possible Infertility can be painful and discouraging, but with the right support, knowledge, and intervention, the dream of holding your child can become a reality
References
1. Pietrzik KF, Thorand B. Folate economy in pregnancy. Nutrition. 1997;13(11-12):975-977. doi:10.1016/s08999007(97)00340-7 https://pubmed.ncbi.nlm.nih.gov/9433714/
2 Xu Y, Ban Y, Ran L, et al Relationship between unexplained recurrent pregnancy loss and 5,10-methylenetetrahydrofolate reductase) polymorphisms Fertil Steril 2019;111(3):597-603 doi:10 1016/j fertnstert 2018 11 011 https://pubmed.ncbi.nlm.nih.gov/30660395/
3 Heidarzadehpilehrood R, Pirhoushiaran M, Abdollahzadeh R, et al A Review on CYP11A1, CYP17A1, and CYP19A1 Polymorphism Studies: Candidate Susceptibility Genes for Polycystic Ovary Syndrome (PCOS) and Infertility Genes (Basel) 2022;13(2):302 Published 2022 Feb 5 doi:10 3390/genes13020302 https://pubmed ncbi nlm nih gov/35205347/
4 Zeng H, Liu Z, Zhang L, Liu N MTHFR 677TT is associated with decreased number of embryos and cumulative live birth rate in patients undergoing GnRHa short protocol: a retrospective study BMC Pregnancy Childbirth 2022;22(1):170 Published 2022 Mar 1 doi:10 1186/s12884-022-04506-4 https://pmc ncbi nlm nih gov/articles/PMC8887009/
6. Choi Y, Kim JO, Shim SH, et al. Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure PLoS One 2016;11(8):e0160884 Published 2016 Aug 25 doi:10 1371/journal pone 0160884 https://pmc ncbi nlm nih gov/articles/PMC4999086/
7. Christensen KE, Mikael LG, Leung KY, et al. High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. Am J Clin Nutr. 2015;101(3):646-658. doi:10.3945/ajcn.114.086603 https://pubmed.ncbi.nlm.nih.gov/25733650/
8 Cirillo M, Fucci R, Rubini S, Coccia ME, Fatini C 5Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology. Int J Environ Res Public Health. 2021;18(23):12280. Published 2021 Nov 23. doi:10.3390/ijerph182312280 https://pmc.ncbi.nlm.nih.gov/articles/PMC8657301/
9 Fernando M, Ellery SJ, Marquina C, Lim S, Naderpoor N, Mousa A Vitamin D-Binding Protein in Pregnancy and Reproductive Health Nutrients 2020;12(5):1489 Published 2020 May 20 doi:10 3390/nu12051489 https://pmc ncbi nlm nih gov/articles/PMC7285222/
10 Ma R, Gu Y, Zhao S, Sun J, Groome LJ, Wang Y Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies Am J Physiol Endocrinol Metab 2012;303(7):E928-E935 doi:10 1152/ajpendo 00279 2012 https://pmc ncbi nlm nih gov/articles/PMC3469619/
11 Pelosi E, Omari S, Michel M, et al Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice Nat Commun 2013;4:1843 doi:10 1038/ncomms2861 https://pmc ncbi nlm nih gov/articles/PMC4504230/
12 Meng X, Peng L, Wei X, Li S FOXO3 is a potential biomarker and therapeutic target for premature ovarian insufficiency (Review) Mol Med Rep 2023;27(2):34 doi:10 3892/mmr 2022 12921 https://pubmed ncbi nlm nih gov/36562359/
13 Zhang QY, Guan Q, Wang Y, et al BDNF Val66Met polymorphism is associated with Stage III-IV endometriosis and poor in vitro fertilization outcome Hum Reprod 2012;27(6):1668-1675 doi:10 1093/humrep/des094 https://pubmed ncbi nlm nih gov/22447624/
14 Ruiz-Sanz JI, Aurrekoetxea I, Matorras R, Ruiz-Larrea MB Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles Fertil Steril 2011;95(5):1601-1605 doi:10 1016/j fertnstert 2010 11 022 https://pubmed ncbi nlm nih gov/21130430/
HEALTH AND WELLNESS WITH THE POWER OF THE MIND
By Susan Nordemo, RN, CI ASW | Monarch Health Coaching and Hypnosis
A good meal plan, exercise, proper medical interventions, and accountability are very important, but the emotional component has a major impact on outcome when there are stressors such as financial instability, young children or elderly family members who require caregiving, and the list goes on Without proper support, the success rate can decrease dramatically in terms of empowering one's health
The success of a person's health plan depends on how you use your brain Research has shown that beliefs and attitudes can directly impact your physical health For instance, stress can trigger the release of hormones like cortisol If it's persistent, your immune system becomes weakened. This can raise blood pressure, and increase the risk of chronic conditions like heart disease and diabetes. On the other hand, it's important to realize a positive mindset has been linked to lower levels of inflammation, improved heart health, and even a longer lifespan.
Practicing mindfulness and meditation, using hypnosis or Reiki for those who want to try them, and following all types of holistic practices can be added to one’s medical treatment It’s necessary to find the right one or maybe two or three different types of holistic care that must be used in conjunction with whatever medical treatment is required, not in place of Visualization is so important, and the negative talk can literally SAP motivation and create anxiety, while positive affirmations build confidence and reinforce sense of control Ultimately, the mind is a powerful ally, and in the quest for well-being, the power of the mind is real and its influence on health and wellness is undeniable By acknowledging this connection and actively nurturing our mental well-being, we unlock a vital tool for leading healthier, happier lives.
Having your DNA tested can bring up emotions, especially if there is a problem The key here is to breathe, sit back, and listen; ask questions and educate yourself on the complementary tools that are out there This can help you follow the DNA plan for your health and wellness
A good example is irritable bowel syndrome (IBS) and other digestive issues Research, including randomized controlled trials, supports the use of hypnotherapy in treating IBS symptoms. The American College of Gastroenterology recommends gut-directed hypnotherapy for IBS management. This works for all types of digestive issues so when you combine hypnotherapy with a DNA plan, it will be much easier to use the plan and stay with it. I have seen this work. This also means possibly less medication, but that will depend on your individual case Also, be educated about what you choose when you pick a complementary therapy What works for one person may not work for another Also, there will be medical professionals who disagree with the complementary factor It will be up to you to educate yourself, talk with appropriate practitioners, and make a decision You want the best outcome for your DNA plan that will help you become and stay healthy
Hypnosis has demonstrated effectiveness comparable to cognitive-behavioral therapy in reducing anxiety disorders It has also been successful in addressing dental anxiety Everything that you see here is impacted by your emotions, which can mean the difference between success and failure.
Hypnosis has been effective in alleviating menopause-related symptoms, such as hot flashes. The North American Menopause Society endorses hypnotherapy for nonhormonal management of these vasomotor symptoms, assigning it the highest level of evidence.
The Arthritis Foundation has approved hypnosis as a viable treatment for pain Think about people with pain whether it be chronic or due to surgery Hypnosis is able to prevent the use of strong pain medications Again, you must be sure that your practitioner has the expertise to work with these conditions As for me, I think STRESS is the number one problem When that is taken care of you are on the beginning of a whole new journey We can’t always think our way out of every illness, but combining mental strategies with physical health practices creates a holistic approach to wellness
My very own quote is my favorite:
“Education is foremost in maintaining one’s health”
“Remember we are the sum of all choices that we make in this life ”
“To my own self be true” Hamlet
“There will be more articles forthcoming on Holistic Practices (so much to learn and enjoy)“
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By using the power of your genetic code, our DNABlueprint crafts completely personalized strategies that address specific health goals - from boosting energy levels to stress management and beyond. This tailored approach not only accelerates your progress but also provides a roadmap for sustained well-being. With DNABlueprint, experience the advantage of clinician support, empowering you to make informed decisions that contribute to a healthier and more fulfilling life. Elevate your wellness journey with science-backed insights and personalized strategies – unlock the full potential of your health with DNABlueprint.
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WHAT I WISH I HAD KNOWN ABOUT MY FERTILITY WHEN I WAS YOUNGER
By Dr Tracey Steady Hardcastle, DACM, MSTOM, CFGP | The DNA Company
My hormones have always rocked my world I struggled with painful, irregular periods in my teens (way back in the 20th century) My female relatives were sympathetic but told me it was “just how it is being a woman.” My doctor suggested I try birth control pills, which I kept trying on and off until my late 20s, despite being sensitive to their side effects. What I didn’t understand was the role my genetics were playing in my menstrual life, or how they would contribute to my infertility later in life. I am far from the only one.
According to the World Health Organization, 1 in 6 people globally are impacted by infertility, and it remains unexplained in many Even when there is a diagnosed cause, there can be very different outcomes from the same intervention due to barriers to care and genetic and epigenetic differences between individuals
Here are some things I learned about my own genetics that I wish I had understood and managed differently at a much younger age:
For starters, because my CYP17A1 gene is genotype GG, I convert progesterone into testosterone quickly, which can lead to a relative excess of testosterone, and sometimes even to premature ovarian failure. If I also metabolized androgens at an increased rate, this would have been less of an issue, but I do not. I have one copy of gene UGT2B17I, and am genotype GT for UGT2B15, so I clear them at a moderate rate. My doctors missed this because I didn’t have obvious signs of androgen dominance. I also convert testosterone into estrogen at a moderate rate because my CYP19A1 is genotype CT, but since my progesterone was being converted quickly into testosterone, and because I clear estrogen slowly because of other genetics, including CYP1A2, I ended up with too little progesterone relative to estrogen, and showed signs of estrogen dominance
My body was also more prone to inflammation from estrogen toxicity because it prefers to convert estrogen into 4-hydroxy
I was able to help myself with those symptoms in my late 20s and early 30s with the help of Traditional Chinese Medicine, but had I known that I was running out of time to have a child, I likely would have considered oocyte cryopreservation (freezing my eggs). I did not meet the right partner until I was in my late 30s, and we did not attempt to have children until my early 40s. By the time I fully understood my genetic picture, it was too late for me to have children using my own eggs, and the window for assisted reproductive technology had passed.
While I did not find out how my genes were affecting my hormones in time to help me maintain a healthy pregnancy, I did find out in time to help myself have a much easier perimenopause, and to optimize my health so that I can live a life free from the ailments that plagued the women on my mom’s side of my family from perimenopause on At the time of this writing, I am 49 and feeling more hormonally balanced than I did at any previous point in my life The self-knowledge I gained from finding out about my genes was empowering, and the selfacceptance I feel as a result of that knowledge helped bring me peace
References
1
World Health Organization 1 in 6 people globally affected by infertility: WHO (04/04/2023)
https://www who int/news/item/04-04-2023-1-in-6-peopleglobally-affected-by-infertility
2
Sadeghi MR Unexplained infertility, the controversial matter in management of infertile couples J Reprod Infertil 2015;16(1):1-
https://pmc ncbi nlm nih gov/articles/PMC4322174/
3
Pisarska MD, Chan JL, Lawrenson K, Gonzalez TL, Wang ET Genetics and Epigenetics of Infertility and Treatments on Outcomes J Clin Endocrinol Metab 2019;104(6):1871-1886
doi:10 1210/jc 2018-01869
DEPRESSION, ANXIETY, AND INFERTILITY: HOW TO REGAIN CONTROL OF YOUR REPRODUCTIVE HEALTH
How Mental Health Affects Fertility
Mental health influences fertility in multiple ways, primarily by disrupting hormone levels and altering physiological functions essential for conception.
Hormonal Disruptions and Ovulation Issues
Depression and anxiety can affect hormone production in ways that make conception more difficult Elevated prolactin levels, often seen in individuals with depression, can suppress ovulation and lead to irregular menstrual cycles [2] Additionally, disruptions in the hypothalamic-pituitary-adrenal (HPA) axis the system that manages stress response can interfere with reproductive hormones An imbalance in luteinizing hormone (LH) can cause irregular ovulation [3,4], while thyroid dysfunction, commonly linked to depression, may contribute to fertility issues by disrupting menstrual cycles [5]
The Role of Stress and Cortisol
Chronic anxiety can keep the body in a prolonged state of stress, leading to high cortisol levels, which interfere with reproductive hormones Stress also reduces blood flow to reproductive organs and shortens the luteal phase, increasing the risk of early miscarriage [6-8]
Poor sleep and nutrition: Inadequate rest and an unbalanced diet disrupt hormone production and ovulation, making conception more challenging.
How to Break the Cycle and Improve Fertility
The good news is that addressing mental health can significantly improve fertility outcomes Research indicates that women who engage in psychological counseling or stress reduction programs experience higher in vitro fertilization (IVF) success rates [9] Here are some practical steps to enhance mental well-being and fertility
1 Manage Stress for Better Hormonal Balance
Chronic stress disrupts hormone regulation, but managing it can restore balance Try: Mindfulness and meditation – Guided breathing exercises and visualization techniques can lower cortisol levels and reduce anxiety [10]
Cognitive-Behavioral Therapy (CBT) – CBT helps reframe negative thought patterns that contribute to stress and anxiety, improving emotional resilience [11]
Acupuncture – Some studies suggest that acupuncture may lower stress hormones and support reproductive health [12]
2 Optimize Lifestyle Choices for Reproductive Health
A healthy lifestyle significantly boosts fertility Consider: Regular exercise – Moderate activities like yoga and walking can lower stress and support reproductive hormone balance [13]
A nutrient-rich diet – Foods high in omega-3s, antioxidants, and B vitamins support both mental and reproductive health [14]
Consistent sleep schedule – Aim for 7-9 hours of quality sleep each night to regulate hormones and improve overall well-being [15]
3 Seek Professional Support
If stress and mental health struggles are impacting fertility, seeking professional support can help. Consider:
Fertility counseling – A counselor specializing in reproductive health can provide coping strategies and emotional support. Medical consultation – A doctor can evaluate stress-related hormonal imbalances and recommend therapies or medications as needed
Support groups – Connecting with others on the fertility journey can reduce feelings of isolation and provide valuable encouragement
Prioritizing Mental Well-Being for Fertility
Infertility isn’t just a physical condition it affects every part of life Addressing mental health can lead to better fertility outcomes and improved emotional well-being If you’re struggling, remember that you are not alone Taking care of your mental health is just as important as taking care of your body By implementing stress-reduction techniques, optimizing your lifestyle, and seeking support, you can improve your chances of
Disclaimer
This article is for informational purposes only and does not replace medical advice Always consult a healthcare professional before making any changes to your fertility or mental health treatment plan
References
1
Rooney KL, Domar AD The relationship between stress and infertility Dialogues Clin Neurosci 2018;20(1):41-47
doi:10 31887/DCNS 2018 20 1/klrooney
2
Miller AH, Maletic V, Raison CL Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression Biol Psychiatry 2009;65(9):732-741
doi:10 1016/j biopsych 2008 11 029
3
Chrousos GP Stress and disorders of the stress system Nat Rev Endocrinol 2009;5(7):374-381 doi:10 1038/nrendo 2009 106
4
5
6
Berga SL, Loucks TL The diagnosis and treatment of stressinduced anovulation Minerva Ginecol 2005;57(1):45-54
Poppe K, Velkeniers B Thyroid disorders in infertile women Ann Endocrinol (Paris) 2003;64(1):45-50
Nepomnaschy PA, Welch KB, McConnell DS, Low BS, Strassmann BI, England BG Cortisol levels and very early pregnancy loss in humans Proc Natl Acad Sci U S A 2006;103(10):3938-3942 doi:10 1073/pnas 0511183103
7
Gollenberg AL, Hediger ML, Mumford SL, et al Perceived stress and the incidence of infertility Epidemiology 2010;21(6):931-937 DOI:10 1097/EDE 0b013e3181f7ef96
8
Frederiksen Y, Farver-Vestergaard I, Skovgård NG, Ingerslev HJ, Zachariae R Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis. BMJ Open. 2015;5(1):e006592 Published 2015 Jan 28
BREAKING THE SILENCE: HOW MODERN LIVING IS FUELING THE ERECTILE DYSFUNCTION EPIDEMIC
By Justin Harris, CFGP | The DNA Company
Erectile dysfunction (ED) is becoming increasingly common, affecting men at younger ages than ever before According to the Journal of Sexual Medicine, one in five men experiencing ED is under 40 years old![1]
When examining the contributing factors to this often-overlooked epidemic, several aspects of modern living stand out as potential culprits
The Environmental and Hormonal Connection to ED
A key concept in understanding the environmental connection to ED is recognizing the environmental signals you provide to your body Are you sending signals that encourage vitality and procreation, or are you inadvertently discouraging them? Our genes are constantly expressing themselves in response to lifestyle inputs and stimuli
Consider a man trapped in a cubicle, spending his days under fluorescent lights, overusing stimulants to stay awake, barely moving his body, exhibiting poor posture with tight hip flexors, stressed, and consuming mostly processed carbohydrates Can you imagine how this lifestyle affects his gene expression? A study published in BMC Public Health on men aged 18-55 concluded that lifestyle significantly impacts men’s sexual health [2]
The above scenario is far from a recipe for vitality In response, his genes signal: “There is no reason for us to maintain a high sex drive We live in a toxic environment and have no need for strength or aggression since we do not engage in physical activity ”
Reversing the Trend: Androgen-Encouraging Lifestyle Changes
What if we changed his environmental signaling by introducing androgen-boosting lifestyle behaviors?
mple lifestyle interventions can significantly restore vitality and ctile function If this hypothetical man were to adopt a rning routine consisting of a few sets of kettlebell swings, namic stretching, breathwork, and a quick cold shower, he uld begin influencing his body's methylation patterns His ne expression would start reflecting his new approach to daily ng A study published by Oxford Academic identified how ch daily physical activity is needed to improve ED [3] his hormones, circulation, psychology, and body awareness prove, numerous health benefits will follow With consistent sitive changes, his baseline vitality will rise, and his sex drive d function will likely improve alongside it
e Role of Genetics in Erectile Function
derstanding one’s genetic profile is crucial for personalizing s process. For instance, if a man has a suboptimal NOS3 gene hich regulates endothelial nitric oxide production), his nitric oxide levels are likely to be low at baseline Since nitric oxide is essential for vasodilation and proper blood flow to the penis, he would benefit from nitric oxide-boosting interventions
One man may have a suboptimal NOS3 gene but an optimal androgen receptor, while another may have the opposite These differences greatly influence the personalized care plans our practitioners develop, setting The DNA Company apart in the functional health space
The Future of ED Treatment: Precision Healthcare
Precision healthcare offers groundbreaking solutions to this modern crisis Functional genomics allows us to pinpoint root causes rather than just treating symptoms
If you or someone you know is struggling with ED, you don’t have to navigate this journey alone By uncovering your unique genetic blueprint, you can take targeted action to restore your vitality, confidence, and overall well-being Reach out to learn how a personalized approach can transform your health because reclaiming your strength starts with understanding your body
References
1
Pozzi E, Capogrosso P, Fallara G, Boeri L, et al Still One Out of Five Men Presenting for Erectile Dysfunction are Young Than 40 Years of Age: Findings of a Real-Life Cross-Sectional Study Over Last Decade The Journal of Sexual Medicine 2022;19(Suppl 4):S83 https://doi org/10 1016/j jsxm 2022 10 030
2
Schlichthorst M, Sanci LA, Hocking JS Health and lifestyle factors associated with sexual difficulties in men - results from a study of Australian men aged 18 to 55 years BMC Public Health 2016;16(Suppl 3):1043 doi:10 1186/s12889-016-3705-6
3
Gerbild H, Larsen CM, Graugaard C, Areskoug Josefsson K Physical Activity to Improve Erectile Function: A Systematic Review of Intervention Studies Sex Med 2018;6(2):75-89
doi:10 1016/j esxm 2018 02 001
INFERTILITY ON THE RISE
By Dr Krista Kostroman, ND, BCS, CFGP, Chief Science Officer | The DNA Company
Infertility is becoming a growing concern, affecting 1 in 6 adults worldwide, according to the World Health Organization This isn’t a niche issue it’s a global reality Over the past few decades, infertility rates have steadily increased, and research shows that men’s average sperm counts have declined by more than 50% in the last 50 years. These numbers make it clear: fertility challenges are not just a personal struggle but a widespread trend that demands attention. So, what’s behind this shift, and how can we begin to address it?
The Numbers Tell a Story
Infertility has become significantly more common in recent generations Its prevalence has risen from about 3 5% to 16 7%, meaning what was once relatively rare is now an everyday concern Across the globe, independent of economic or development status, around 17 5% of adults about one in six will experience infertility at some point in their lives While highincome countries often have greater access to fertility treatments, they are not immune to rising infertility rates, with lifestyle factors, environmental exposures, and delayed childbearing playing significant roles
Male reproductive health has also changed dramatically Studies reveal that sperm concentrations have dropped by 51 6% globally in the past half-century To put it in perspective, today’s average man has less than half the sperm count his grandfather did at the same age Total sperm counts have declined even more over 60% in that same timeframe Clearly, something in our modern environment and lifestyle is having a profound impact on fertility for both men and women
Hidden Culprits: Environment, Lifestyle, and Diet
So what’s driving this rise in infertility? The answer isn’t simple, but we do know that multiple factors are at play Enviro toxins are a major contributor Endocrine-disrupting ch (EDCs), found in plastics, pesticides, and even perso products, can interfere with hormone function and ne affect fertility Heavy metals like lead and cadmium h been linked to hormonal imbalances and reproductive Even air pollution is suspected to play a role, with suggesting that long-term exposure to fine particulate m associated with higher infertility rates In short, many conveniences of modern life come with hidden repr costs
Lifestyle factors also have a significant impact. Age is on biggest considerations, particularly for women. Whi people are delaying parenthood into their 30s and 40s, hasn’t caught up with modern life Female fertility b decline around age 32 and drops more after 37 S another important factor Chronic stress can disr hormones that regulate ovulation and sperm production have found that higher stress levels are associated wit times to conception and an increased risk of infertility, cr cycle where infertility itself becomes an added stressor
Other lifestyle habits compound the issue Obesity is a welldocumented risk factor for infertility In women, excess weight can lead to hormonal imbalances and ovulation problems, with obese women having about three times the risk of infertility compared to those at a healthy weight Men are also affected obese men are significantly more likely to face fertility issues, likely due to lower testosterone levels and poorer sperm quality.
Smoking and alcohol use add to the problem. Smoking can accelerate egg loss, cause DNA damage to sperm, and increase miscarriage risk. Studies suggest that smokers are up to 60% more likely to experience infertility than non-smokers. Heavy alcohol consumption can also reduce fertility; research on couples undergoing in vitro fertilization (IVF) found that women who drank four or more alcoholic drinks per week had significantly lower pregnancy success rates And when both partners were heavy drinkers, the chances of a live birth dropped even further
Diet plays a crucial role as well Diets high in ultra-processed foods and low in nutrients have been linked to longer times to conception A large study found that women who ate fast food frequently and little fruit took longer to conceive and were more likely to struggle with infertility Simply put, the body thrives when given the right fuel, and fertility is no exception
A Holistic Approach to Fertility
Because infertility stems from multiple causes, it makes sense that there’s no single solution. We can’t turn back time or instantly rid the world of pollutants, but we can take steps to support reproductive health Experts emphasize a multifactorial approach addressing as many contributing factors as possible to improve fertility outcomes
On an individual level, small lifestyle changes can make a meaningful difference Research shows that weight loss and exercise can significantly improve fertility, with women in dietand-exercise programs nearly twice as likely to conceive compared to those who made no changes Reducing alcohol intake and quitting smoking can gradually reverse some of the damage these habits cause to reproductive cells. Managing stress through mindfulness, therapy, or support networks can also help restore hormonal balance. And focusing on a nutrientrich diet full of whole foods, antioxidants, and key fertilitysupporting nutrients can create a more favorable environment for conception.
Beyond lifestyle changes, medical science is evolving to offer more personalized fertility solutions Advances in genetic and metabolic testing are helping doctors tailor treatments to individual needs For example, some people are more sensitive to environmental toxins due to genetic variations, meaning targeted detox strategies could improve their fertility outcomes Fertility specialists are also using precision medicine to analyze hormone levels and optimize treatment plans, improving success rates for those undergoing fertility treatments like IVF
Ultimately, infertility is a complex challenge, but the good news is that we have more tools than ever to address it A combination of lifestyle adjustments, medical advancements, and a deeper understanding of environmental factors is giving many hopeful parents a better chance at conception While there’s no one-size-fits-all answer, each step taken whether it’s prioritizing nutrition, reducing stress, or seeking personalized medical care moves us closer to a solution By embracing a comprehensive approach, we can support fertility in a way that acknowledges both the challenges and the possibilities ahead
References
1.
Centers for Disease Control and Prevention. (2024). Infertility (FastStats). National Center for Health Statistics. https://www.cdc.gov/nchs/fastats/infertility.htm.
2.
Chandra A, Copen CE, Stephen EH. Infertility service use in the United States: data from the National Survey of Family Growth, 1982-2010. Natl Health Stat Report. 2014;(73):1-21. https://www cdc gov/nchs/data/nhsr/nhsr073 pdf
3
Leslie SW, Soon-Sutton TL, Khan MAB Male Infertility In: StatPearls Treasure Island (FL): StatPearls Publishing; February 25, 2024
4
Siegel DR, Sheeder J, Polotsky AJ Racial and Ethnic Disparities in Fertility Awareness Among Reproductive-Aged Women Womens Health Rep (New Rochelle) 2021;2(1):347354 Published 2021 Aug 19 doi:10 1089/whr 2021 0034
6
World Health Organization (2004) Infecundity, infertility, and childlessness in developing countries (DHS Comparative Reports No 9) Geneva, Switzerland: World Health Organization; Calverton, MD: ORC Macro https://dhsprogram com/pubs/pdf/CR9/CR9 pdf
5 World Health Organization (2023) Infertility prevalence estimates, 1990–2021 Geneva, Switzerland: World Health Organization https://iris who int/bitstream/handle/10665/366700/97892400 68315-eng pdf
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UNDERSTANDING GENETIC NOTATION: A BEGINNER'S GUIDE
By Dr Lara Varden, PhD, BCHHP, LEHP, CFGP, CFNC | The DNA Company
Genetics can seem complicated, but with a little practice, you can learn to read genetic notations like a scientist Whether you’re looking at single nucleotide polymorphisms (SNPs), copy number variations (CNVs), or insertions and deletions (Indels), these genetic markers can tell us a lot about health, traits, and even how our bodies process nutrients. Let’s break it down...
1. Single Nucleotide Polymorphisms (SNPs): The “Typos” in Your DNA
Imagine your DNA as a long book written with only four letters: A, T, C, and G A single nucleotide polymorphism (SNP) is like a small typo in the book where one letter is swapped for another These minor changes can sometimes alter the meaning of a word, and in genetics, they may change how a gene functions
This gene is responsible for an enzyme involved in folate metabolism and methylation processes
Reference SNP (rs) ID: rs1801133 – This is the unique identifier for this specific SNP in genetic databases Nucleotide Change (C677T): This refers to a specific point
How to Apply This to Other Gene Descriptions
When you see a description like rsXXXXX (A123G) or Met17Val, you can break it down using the same logic:
Gene Name (if provided): Identifies which gene the SNP is in. rs ID: A unique identifier for the SNP. Nucleotide Change (e.g., A123G):
The first letter (A) is the original (wild-type) nucleotide.
The number (123) is the position in the gene where the mutation occurs
The second letter (G) is the mutated (variant) nucleotide Amino Acid Change (e g , Met17Val (M17V)): Some SNPs result in an amino acid substitution, altering the protein's function (Psst amino acids are made up of combinations of three nucleotides, and proteins are made up of a string of amino acids):
The first amino acid (e g , Methionine, Met, M) is the original (wild-type) amino acid
The number (e g , 17) is the position in the protein where the change occurs
The second amino acid (e g , Valine, Val, V) is the variant amino acid
This can be written as Met17Val or M17V
THE FUTURE OF PERSONALIZED PSYCHIATRY: HOW PHARMACOGENETICS IS REVOLUTIONIZING DEPRESSION
Modern psychiatry has made tremendous advances and has saved countless lives But we can do better By leveraging cutting-edge science, we can ease the burden of treatment and improve outcomes through personalized medicine
The burgeoning field of pharmacogenetics the study of how genes affect an individual's response to medications offers a way forward Using genetic testing, along with other biomarkers and patient history, we can move beyond one-size-fits-all treatment We can tailor mental health interventions to the individual, increasing the likelihood of treatment success and reducing unnecessary suffering
The DNA Company’s PGx testing provides insights into gene variations affecting medication response, while the DNA 360 test offers information on genes that interact with nutritional, psychological, and other interventions. This is what genomics is meant to do, to help us understand a person on a deeper level to optimize their treatment plan.
Using depression treatment as an example, let's explore what the future of personalized psychiatry looks like by examining key genetic factors These are just a few of the many genetic insights available to guide mental health treatment
From Trial and Error to Tailored Treatment
Serotonin, a key neurotransmitter involved in mood regulation, plays a central role in depression treatment Selective serotonin reuptake inhibitors (SSRIs), which increase serotonin availability, are among the most commonly prescribed antidepressants However, response to these medications varies widely
The STAR*D study, a large-scale investigation into SSRI effectiveness published in the American Journal of Psychiatry (2006), found that about 70% of participants did not achieve remission with their first medication trial, and over 50% had no response at all Even after four treatment trials, only about 67% achieved remission and these numbers may be inflated due to statistical adjustments This highlights the limitations of traditional, trial-and-error psychiatry
Pharmacogenetics offers a way to shift this paradigm While genetic testing cannot guarantee the perfect treatment, it does increase the likelihood of a positive response, reduce the number of failed medication trials, and minimize side effects
The Role of the 5-HTTLPR Polymorphism in SSRI Response
The SLC6A4 gene encodes the serotonin transporter protein, which plays a crucial role in regulating serotonin levels. One well-studied variation in this gene, the 5-HTTLPR polymorphism, affects serotonin transporter efficiency.
The S/S genotype of this polymorphism is associated with lower serotonin transporter function, higher susceptibility to depression, and poorer SSRI response On the other hand, the L/L genotype is linked to higher serotonin transport efficiency and better SSRI response, with fewer side effects
For individuals with the S/S genotype, SSRIs may not be the best first-line treatment Instead, alternative medications targeting other neurotransmitters or non-pharmacological approaches may be more effective, reducing the frustration of ineffective treatment trials
The Role of Cytochrome P450 Enzymes in Medication Metabolism
Beyond neurotransmitter function, an individual’s ability to metabolize medications and supplements plays a crucial role in treatment success. The cytochrome P450 (CYP450) enzyme system, primarily found in the liver, is responsible for breaking down many psychiatric medications, including SSRIs
Variations in CYP450 genes, particularly CYP2C19, CYP2D6, and CYP3A4, determine how quickly a person processes medications Ultra-rapid metabolizers (UMs) break down SSRIs very quickly, leading to reduced drug effect and possibly low treatment response Whereas poor metabolizers (PMs) process SSRIs very slowly, resulting in higher drug levels, increased side effects, and potential toxicity
Expanding Personalized Treatment Options
Beyond 5-HTTLPR and CYP450, other genetic factors influence depression treatment response For example:
Brain-Derived Neurotrophic Factor (BDNF): The commonly studied single nucleotide polymorphism (SNP) in this gene, numbered rs6265, benefits from exercise or ketamine-based treatments
Tryptophan Hydroxylase 2 (TPH2): This gene plays a role in serotonin synthesis, with variations in this gene influencing baseline serotonin levels and antidepressant response
Epistatic (combined) Influence of TPH2 and BDNF: When both TPH2 and BDNF have the GG genotype, there can be an unexpected suppression effect on the GG BDNF genotype that we would normally consider to be optimal This means that we must read genes together and consider how they affect one another, not simply using single-gene analysis
Understanding these interactions allows for even more refined treatment decisions, highlighting the importance of a multi-gene approach in personalized psychiatry
By considering multiple genetic factors, we can refine treatment approaches, optimizing interventions beyond medication alone
The Future of Personalized Psychiatry
Psychiatry is entering a new era Pharmacogenetic and genomic testing allows us to move beyond symptom-based prescribing toward a science-driven, individualized approach to mental health care, and it's about time Rather than relying on trial and error, we can leverage genetic insights to guide treatment selection, improving response rates and reducing side effects
I'm imagining a future where a simple genetic test provides a roadmap to optimal treatment one that considers not only SSRIs but also alternative interventions like dietary modifications, exercise, and mind-body therapies This approach reduces suffering, shortens the treatment journey, and improves long-term outcomes.
The tools for this transformation already exist As more clinicians integrate pharmacogenetics into practice, we move closer to a psychiatry that truly meets patients where they are offering precision, effectiveness, and hope for those struggling with mental health conditions.
References
1 Pigott HE, Kim T, Xu C, Kirsch I, Amsterdam J What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study's patient-level data with fidelity to the original research protocol BMJ Open 2023;13(7):e063095 Published 2023 Jul 25 doi:10 1136/bmjopen-2022-063095
3
Jackson JL, Kuriyama A, Bernstein J, Demchuk C Depression in Primary Care, 2010-2018 Am J Med 2022;135(12):1505-1508 doi:10 1016/j amjmed 2022 06 022
2 Rush AJ, Trivedi MH, Wisniewski SR, et al Acute and longer-term outcomes in depressed outpatients requiring one or several treatment t STAR*D t A J P hi t 2006 163(11) 1905 1917
UNLOCK YOUR HEALTH POTENTIAL: THE DNA WAY
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Author and Co-Founder
“The
knowledge you need for your own longevity and vitality. ”
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THE HIDDEN CONNECTION: BONE HEALTH, THE MAXILLA, AND WOMEN’S WELLNESS
By Dr. Mandeep Johal, DMD, Functional Dentist | Founder of H.E.A.L
When we talk about women’s health, osteoporosis and bone strength often come up especially as we age But did you know one of the first bones to weaken isn’t in your spine or hips, but your face? It’s called the maxilla, and it’s not just your upper jaw This key bone reaches up to the lower part of your eyes and holds up your cheekbones, shaping your face As a functional dentist, I’ve seen how the maxilla’s health connects to how we look, breathe, and feel and it’s something women need to hear about
Bone Health Starts with Chewing
Here’s the exciting part: we can fight back Bone grows when it’s stressed, like how lifting weights builds your arms Chewing harder foods can strengthen your maxilla Research shows that consistent chewing boosts jawbone density over time (4) Try eating crunchy veggies and nuts or even chewing sugar-free gum it wakes up your jaw Yet, many women live on soft diets smoothies and processed snacks that don’t challenge their bones enough
The maxilla starts to resorb or shrink earlier than most bones, often in our 30s Research shows that facial bone loss, including the maxilla, can begin as early as this decade due to natural aging and hormonal shifts, especially in women (1) After menopause, dropping estrogen levels speed this up, since estrogen helps keep bones dense (2) But many of us start with weaker maxillae even before then Why? Modern habits like eating soft foods and chewing less have led to smaller, less developed facial bones over time Our ancestors chewed tough foods like roots and meat, giving them wider, stronger faces Today, softer diets mean smaller maxillae and weaker foundations.
A shrinking maxilla changes more than your smile As it resorbs, your cheekbones lose support, your eyes may sink, and your jawline softens How many women do you know who’ve gotten fillers or Botox to fix these changes, without knowing the real cause? It’s not just skin deep it’s the bones underneath Studies confirm that maxillary bone loss alters facial structure, often starting in the 30s and worsening with age (3)
k maxilla also narrows your airway, making breathing especially at night. Journalist James Nestor, in his book , shared how expanding his upper jaw widened his airway mproved his health (5) This method, called airway ontics, uses dental appliances to gently grow the maxilla in adults Better breathing means better sleep and more , which every woman deserves.
Women Need This Conversation
told to lift weights for osteoporosis, and that’s true bones are our structure But women often spend more on tics than gym memberships What if we focused on the beneath the surface instead? A healthy maxilla fights osteoporosis, keeps your airway open, and supports your e by aligning your head and neck Unlike fillers, these fixes
You Can Do Today
Start simple: swap soft snacks for carrots or apples Chew gum after meals to work your jaw If you snore or feel tired despite sleep, talk to a functional dentist about your airway. And keep lifting weights your whole skeleton will thank you Women deserve to know that bone health isn’t just about avoiding breaks It’s about breathing well, aging confidently, and feeling strong Let’s talk about the maxilla not just in dental chairs, but everywhere. When we support our bones, they support us back
References
1
2
Levine JP Identification, diagnosis, and prevention of osteoporosis
Am J Manag Care 2011;17 Suppl 6:S170-S176
Riggs BL, Khosla S, Melton LJ 3rd Sex steroids and the construction and conservation of the adult skeleton Endocr Rev 2002;23(3):279302 doi:10 1210/edrv 23 3 0465
3
Shaw RB Jr, Kahn DM Aging of the midface bony elements: a threedimensional computed tomographic study Plast Reconstr Surg 2007;119(2):675-683 doi:10 1097/01 prs 0000246596 79795 a8
4
Kiliaridis S, Bresin A, Holm J, Strid KG Effects of masticatory muscle function on bone mass in the mandible of the growing rat Acta Anat (Basel) 1996;155(3):200-205 doi:10 1159/000147805
5
Nestor J Breath : The New Science of a Lost Art Riverhead Books, an imprint of Penguin Random House LLC; 2020.
The Maxilla: Your Face’s Foundation
UNDERSTANDING BONE LOSS AND MENOPAUSE
By Myriam Llano | Founder of Divine Renewal
One of the more common yet non-symptomatic consequences of perimenopause and menopause is bone loss, which occurs when the body breaks down more bone than it produces. This process can lead to thinner, weaker bones and the disease known as osteoporosis. As a functional medicine nutritionist, menopause expert, and woman’s health coach and a woman in menopause I do a lot of research and consult with many women about this transitional time of life
Women at Risk of Bone Loss
Bone loss and osteoporosis are critically important to understand, as about one-third to one-half of women older than 50 will experience a broken bone associated with osteoporosis A woman’s risk of breaking her hip because of bone loss is the same as the combined risk of her risk of having breast, uterine, and ovarian cancer
The majority of symptoms and consequences of perimenopause and menopause are things we can feel, see, or experience We can identify hot flashes, headaches, mood swings, dry skin, tender breasts, urinary incontinence, and fatigue But we cannot see bone loss and osteoporosis unless we get our bone density tested and see the results, or we break or fracture a bone and a doctor makes the diagnosis So, for many women, bone loss and osteoporosis can be hidden conditions
When Does Bone Loss Begin?
What’s going on with a woman’s bones in menopause? The risk of bone loss and osteoporosis actually begins before perimenopause. Generally, women’s bones are smaller and thinner than men’s, and females who don’t follow a healthy diet (with sufficient calcium, vitamin D, and other essential nutrients for bone health), get regular exercise, and have minimal exposure to alcohol and nicotine throughout their lives run a greater chance of osteoporosis than their peers who have a healthier lifestyle Some other general risk factors for osteoporosis include low body mass, parental history of hip fracture, and being white Latina women have a lower risk, but it is still very significant
Declining levels of estrogen are associated with bone loss because this hormone is essential for bone health and maintaining bone density Women can lose up to 20% of their bone density within five to seven years after reaching menopause That’s one reason why it’s essential for women to have their bone density tested at least by age 65 The test is called a dual-energy X-ray absorptiometry (DEXA), and it is a painless imaging procedure that takes only a few minutes It can be performed in a doctor’s office, clinic, or outpatient facility and lets you and your doctor know if you are experiencing bone loss and how severe it may be
Ways to Prevent and Tackle Bone Loss
You can help prevent and slow bone loss by adopting some lifestyle changes When you combine these steps together, you can have a significant impact on your bone health For example:
Exercise regularly Before you begin, talk to your doctor about the exercises that are best suited for your needs and current health Three types of exercise can help promote and maintain bone health, and you don’t need to join a gym to do them You can follow videos online, exercise with friends or family, or work out alone
Strength training can help maintain bone density and strengthen your muscles All you need is your own body weight (by doing pull-ups, push-ups, planks), hand weights, and/or resistance bands Start with low weight and slowly increase it over time Do strength training for 20 minutes twice a week
Weight-bearing exercise, such as tennis, dancing, aerobics, Zumba, hiking, and walking Strive for 30 to 45 minutes four to five days a week Balance exercises, which can help prevent falls and broken bones, are highly recommended A physical therapist or nurse can demonstrate balance exercises for you Tai chi and yoga poses also can improve balance
Avoid alcohol, caffeine, and nicotine These can reduce bone density The more caffeine you consume, for example, the more calcium is leached from your bones
Focus on bone-healthy foods Foods rich in calcium (broccoli, leafy greens, chia seeds, dried figs, almonds, sardines, kale, sweet potatoes) are great examples If you take calcium supplements, you can optimize absorption if
Your bones need vitamin D to properly absorb calcium The best source is exposure to about 20 minutes of sunlight (without sunscreen) four to five days a week A vitamin D supplement is often recommended but have a simple blood test to determine your vitamin D level before you take a supplement Your healthcare provider can choose the best dose for you
Magnesium works closely with calcium Foods rich in this mineral include leafy greens, seeds, nuts, avocados, and bananas If you want to take a supplement, magnesium bisglycinate, chelate, and citrate are suggested
Limit your intake of phosphorus because it promotes bone loss. Soft drinks, red meat, dairy products, and beer are high in this mineral.
These lifestyle changes can help support bone density and ward off bone loss in the menopause years The best time to start these changes is today!
References
2
1 Sözen T, Özışık L, Başaran NÇ An overview and management of osteoporosis Eur J 2017;4(1):46-56 doi:10 5152/eurjrheum 2016 048
Bone Health & Osteoporosis Foundation What women need to know Accessed February 24, 2025 https://www bonehealthandosteoporosis org/preventingfractures/general-facts/what-women-need-to-know/
Visit: https://www linkedin com/in/myriamllano/
HOW DO YOU KNOW IF YOUR BIOIDENTICAL HORMONE THERAPY WILL PROTECT YOUR BONES
By Betty Murray, PhD, MS, IFMCP | Living Well Dallas
Sarah was like many women entering menopause – concerned about maintaining her health and preventing the bone loss that often accompanies this life transition Eight years ago, her dualenergy X-ray absorptiometry (DEXA) scan results were reassuring, showing adequate bone mineral density at the start of her menopause journey Wanting to take a proactive approach to her health, Sarah sought out a practitioner who prescribed bioidentical hormone replacement therapy (BHRT)
This should have been the beginning of a successful health maintenance strategy After all, estrogen replacement was approved for treating osteoporosis back in 1988, and Sarah was doing everything right She maintained a healthy diet with adequate protein, lifted weights regularly, and stayed physically active The bioidentical hormones should have provided protection for her bones
But there was a critical flaw in her treatment plan
A False Sense of Security
For seven years, Sarah's practitioner never checked her lab values She was simply told that as long as she wasn't experiencing hot flashes or night sweats, her hormone therapy was working properly Based on this advice, Sarah believed she was receiving optimal care and protection against bone loss When Sarah eventually came to our telemedicine practice, she wasn't experiencing obvious symptoms but wanted to confirm she was being treated properly What we discovered was alarming
The Shocking Discovery
When she started working with our practitioners at Menrva,we conducted comprehensive clinical testing, including a repeat DEXA scan The results were concerning – Sarah had developed osteoporosis despite being on hormone replacement therapy for seven years while also lifting weights, eating healthy, and taking the “right” supplements She had lost a significant amount of bone density, even though she had been following her prescribed treatment and maintaining healthy lifestyle habits How could this happen? The answer lay in the details that had been overlooked in her previous care
Understanding Bone Health and Hormones
To understand what went wrong in Sarah's case, we need to look at how hormones affect bone health.
Bones are constantly being remodeled through the activity of two main cell types: osteoblasts and osteoclasts Osteoblasts are bone-forming cells derived from mesenchymal stem cells They produce the organic components of bone matrix called osteoid (DeMartinis et al , 2021) Osteoclasts, conversely, are bone-resorbing cells that break down old or damaged bone (DeMartinis et al , 2021)
Estradiol, the primary form of estrogen, plays a crucial role in maintaining this delicate balance It inhibits bone resorption by reducing bone reabsorbing (osteoclast activity) and lifespan while promoting bone building (osteoblast function) (Väänänen and Härkönen, 1996) Estradiol also regulates bone remodeling by decreasing osteoblast death and increasing osteoclast death, essentially shortening the bone resorption period
In postmenopausal women, the sharp decline in estrogen levels significantly accelerates bone loss (Väänänen and Härkönen, 1996) This is why women typically experience a rapid increase in osteoporosis risk as they go through menopause (Väänänen and Härkönen, 1996) In fact, osteoporosis is approximately four times more common in women than in men, with about 80% of women over 65 affected compared to 50% of men in the same age group
Why Sarah's Hormone Therapy Failed
When we analyzed Sarah's bloodwork and hormone metabolism, we discovered two critical issues:
Inadequate estradiol levels: Despite being on bioidentical hormone therapy, Sarah's estradiol levels were too low to provide the bone protection she needed. Proper dosing is essential, as estradiol's bone-protective effects are dosedependent
Genetic factors affecting hormone metabolism: Sarah's genetic profile revealed variations that affected how her body processed and utilized hormones These genetic factors created gaps in her treatment and increased her risk for bone loss despite hormone therapy
The science is clear: estradiol protects bone by inhibiting bone resorption through multiple mechanisms It reduces bone reabsorption by blocking inflammatory activity that causes an acceleration of bone loss
However, these protective effects only occur when estradiol is present at physiologically appropriate levels In Sarah's case, her prescribed dose was simply insufficient to provide this protection
The Importance of Comprehensive Testing and Personalized Treatment
Sarah's case illustrates a critical lesson: simply being on hormone replacement therapy isn't enough Treatment must be personalized based on:
Regular lab testing: Monitoring hormone levels ensures that therapy is providing physiologically appropriate levels of hormones
Genetic testing: Understanding how an individual's genetic makeup affects hormone metabolism can reveal potential vulnerabilities and guide treatment adjustments
Bone density monitoring: Regular DEXA scans allow for early detection of bone loss and timely intervention
Comprehensive approach: Beyond hormones, addressing inflammation, ensuring adequate nutrition (especially protein, calcium, vitamin D, vitamin K), and maintaining appropriate exercise are all essential for bone health
Sarah's Path Forward
After identifying the gaps in Sarah's treatment, we developed a comprehensive plan to address her osteoporosis and prevent further bone loss:
Adjusted hormone therapy: We modified Sarah's bioidentical hormone replacement to achieve physiologically appropriate estradiol levels
Personalized supplementation: Based on her unique needs, we added key nutrients including:
Vitamin D3 for calcium absorption and bone mineralization (Elshaikh et al , 2020)
Vitamin K2 (MK-4 and MK-7) to support bone formation (Elshaikh et al , 2020)
Adequate protein to support muscle building and bone formation
Anti-inflammatory diet with optimal levels of antioxidants, fiber, phytonutrients, and anti-inflammatory omega3 fats to reduce bone resorption
Continued weight-bearing exercise: We encouraged Sarah to maintain her strength training routine, as mechanical loading is essential for bone formation
Regular monitoring: We implemented a schedule of regular lab testing and follow-up DEXA scans to track her progress and make adjustments as needed.
Dialed in protein intake We increased Sarah’s protein intake to 120g daily to ensure muscle building and bone building (Kędzia et al., 2023).
Insist on comprehensive testing: Regular lab work, more extensive genetic and hormone metabolism testing, and bone density scans are essential for monitoring treatment effectiveness
Consider genetic factors: How your body processes hormones can significantly impact treatment outcomes
Take a holistic approach: Hormones are just one piece of the bone health puzzle Nutrition, exercise, inflammation management, and stress reduction all play important roles
Conclusion
Sarah's case demonstrates why it's crucial not only to initiate bioidentical hormone replacement but to ensure the treatment is physiologically appropriate and biologically effective Regular testing and monitoring are essential to confirm that hormone therapy is providing the expected protection for bones, heart, and brain health
Unfortunately, Sarah's experience is not unique Many women receive hormone therapy without adequate monitoring, leaving them vulnerable to bone loss despite treatment By sharing Sarah's story, we hope to raise awareness about the importance of comprehensive, personalized care during menopause
With the right approach combining appropriate hormone therapy, targeted supplementation, regular exercise, and ongoing monitoring women like Sarah can protect their bone health and enjoy active, vibrant lives throughout menopause and beyond
If you’d like some additional support to assist you in understanding your hormones and the transition to menopause, check out my weekly podcast at Menopause Mastery Podcast (apple, spotify, and amazon music) on your favorite podcast app You can also explore comprehensive menopause care through my telemedicine company, Menrva
References
1
2
Alswat KA Gender Disparities in Osteoporosis 2017;9(5):382-387 doi:10 14740/jocmr2970w
De Martinis M, Sirufo MM, Polsinelli M, Placidi G, Di Silvestre D, Ginaldi L Gender Differences in Osteoporosis: A SingleCenter Observational Study World J Mens 2021;39(4):750759 doi:10 5534/wjmh 200099
3
Elshaikh AO, Shah L, Joy Mathew C, Lee R, Jose MT, Cancarevic I Influence of Vitamin K on Bone Mineral Density and Osteoporosis 2020;12(10):e10816 Published 2020 Oct 5 doi:10 7759/cureus 10816
Lessons for All Women in Menopause
Sarah's experience offers valuable lessons for women navigating menopause and hormone replacement therapy:
Don't rely solely on symptoms: The absence of hot flashes doesn't guarantee that hormone levels are optimal for bone protection, nor does it ensure that you are getting the optimal amounts for protecting the heart and brain
4
5
Väänänen HK, Härkönen PL Estrogen and bone metabolism 1996;23 Suppl:S65-S69 doi:10 1016/0378-5122(96)01015-8
Kędzia G, Woźniak M, Samborski W, Grygiel-Górniak B Impact of Dietary Protein on Osteoporosis Development 2023;15(21):4581 Published 2023 Oct 28 doi:10 3390/nu15214581
Visit: livingwelldallas com | getmenrva com Facebook: drbettymurray | Instagram @drbettymurray LinkedIn: betty murray | Blog: bettymurray com
EXERCISING AND BONE HEALTH: THE ROLE OF PHYSICAL ACTIVITY IN PREVENTING OSTEOPOROSIS
By Felicia Bruno, CFGP | The DNA Company
Bone health is an essential aspect of overall well-being, particularly as we age Bones provide structure and support for the body, protect internal organs, and enable mobility As people age, their bones may weaken, leading to conditions like osteoporosis Osteoporosis is a progressive condition characterized by brittle, fragile bones that are more prone to fractures Exercise plays a significant role in maintaining bone density and preventing the onset of osteoporosis
Osteoporosis leads to an increased risk of fractures, particularly in the hip, spine, and wrist The good news is that lifestyle factors, particularly physical activity, can help slow down the loss of bone mass This is crucial because, as a child, the body builds bone mass faster than it breaks down and this continues until we reach age 30 After that, the bone mass gradually decreases, but don’t be discouraged by this This is where we can take charge and take action to live the best life we can long into our elderly years, with confidence and great health
How do we achieve this: Through exercise and being active Examples of this are easily achievable; we just must do it Running, hiking, dancing, and climbing stairs are perfect for creating bone strength. These activities put stress on bones, helping to maintain and even build bone density over time.
Resistance training IS A MUST and my favorite You can change how you look and be stronger doing it Resistance or strength training exercises involve working against a force to strengthen muscles, ligaments, and bones While building muscle mass, resistance training also promotes bone strength Lifting weights, using resistance bands, or performing body-weight exercises (like squats or push-ups) challenge the bones by loading them with forces that promote the development of stronger bone tissue
For osteoporosis prevention, strength training is particularly beneficial because it targets the bones in the spine, hips, and wrists, areas most vulnerable to fractures in people with
How long do you do these exercises or how many days, you ask?? People over 65 need at least 2½ hours a week That’s not a lot, and I promise once you start, the stronger you will get Exercise affects your mood, mind, bones of course, and you will want to do more
Another great reminder about exercise is that it also helps regulate hormones, such as estrogen and testosterone, which play a role in bone health. For women, regular physical activity, especially weight-bearing and resistance exercises, can help mitigate the decline in estrogen levels that occur after menopause Since low estrogen levels are a significant contributor to osteoporosis in women, maintaining an active lifestyle can help protect bone health
Now, if you do have osteoporosis, I want you to be very aware of what not to do High impact activities such as jumping, running, or swinging a golf club can be bad due to their explosive motion and twisting of the body Instead, focus on the low impact activities I mentioned above like walking, bike riding, and weight lifting, being careful on sit-ups and using proper form during movements.
Again, weight-bearing exercises, resistance training, and balance activities help stimulate bone growth, maintain bone density, and reduce the risk of fractures By being active you can significantly improve your bone health and reduce your risk of osteoporosisrelated complications Regular exercise, along with a balanced diet rich in calcium and vitamin D, forms the foundation of a bone-healthy lifestyle
With all this said, I want to encourage you to just move your body, your bones will thank you, and your mind and happy thoughts will follow I’m always here to answer questions and happy to help in any way You can contact me at Felicia bruno@thednacompany com or via Instagram at @feliciafitsocial Let’s live the width of life and not just the length with strong happy bodies!!!!
SPRINGTIME SUPERFOODS: YOUR BONE-BUILDING BOUNTY
younger age and more rapid pace As women approach and transition through menopause, declining estrogen levels can dramatically accelerate bone loss, putting them at an alarmingly high risk of developing osteoporosis. I wrote down the names of 14 of my fabulous looking women friends and I was shocked to realize that eight of my friends has had a bone fracture after the age of 55. This stark reality underscores the critical importance of taking proactive steps to optimize bone health long before, and after, the onset of menopause.
You can support your bone health through the bioavailable bonebuilding nutrients found in food at any time By aligning your nutritional approach with the principles of Traditional Chinese Medicine, you can leverage your body’s own natural rhythms and seasonal cycles to optimize bone health in a way that goes beyond simply ensuring adequate calcium, protein, and Vitamin D intake This holistic framework, which prioritizes the health of the liver and gallbladder as the foundation for strong bones, represents an effective strategy for women seeking to maintain skeletal health as they age A well-functioning liver ensures the proper metabolism of minerals like calcium, magnesium, and phosphorus, which are vital for bone strength Supporting liver health in Spring with seasonal foods rich in vitamins, antioxidants, and alkalizing properties can optimize bone maintenance.
In Spring, an array of nutrient-dense foods that nourish bones while supporting liver function are abundant Whenever possible, choose organic fruits and vegetables to avoid the multitude of pesticides and herbicides that are sprayed on commercial crops
2 eggs scrambled in a bowl (or 1/2 block firm tofu, crumbled for vegan option)
1/4 tsp grapeseed oil
1/2 tsp garlic powder (optional)
1/4 tsp sea salt (avoid using table salt)
1/4 cup chopped spring onions
1/2 avocado
1 tbsp pumpkin seeds (dry roasted in a pan until they pop)
Directions:
Heat 1/4 tsp grapeseed oil in a pan on medium heat. After a minute, add the egg mixture (or the crumbled tofu)
Stir garlic powder and salt Cook, stirring for 2-4 minutes until cooked to your preference
Serve eggs over cooked quinoa, topped with spring onions, avocado slices, and pumpkin seeds.
2. Almond Flour Protein Pancakes (21g protein, 180mg calcium per serving)
Ingredients:
1 cup almond flour
2 eggs (or flax eggs for a vegan option)
1 tbsp chia seeds
1/2 tsp baking soda
1/2 tsp cinnamon
1/2 tsp vanilla extract
1/4 cup almond milk
1 tbsp maple syrup (optional)
Coconut oil for cooking
Directions:
Mix all ingredients in a bowl until a thick batter forms
Heat coconut oil in a pan and then pour small pancakesized portions of batter
Cook until golden brown, for 2-3 minutes per side
Serve with fresh berries, a handful of raw pistachio nuts, and a drizzle of maple syrup
PS: If your morning is off to a hectic start simply chuck 1 banana, 1 egg, and 1 tbs ground flaxseeds into a blender to create a pancake batter, then follow steps 2-4 above and enjoy
3 Sautéed Asparagus & Spring Onion with Sesame (5g protein, 120mg calcium per serving)
Ingredients:
1 bunch asparagus, trimmed and cut into pieces
2 spring onions, sliced
1/2 tsp grape seed oil
1 tbsp sesame seeds (dry roasted in a pan)
1 tbsp tamari or coconut aminos
1 tsp lemon zest
Directions:
Heat oil in a pan on medium heat.
Sauté asparagus and spring onions for 4-5 minutes.
Stir in sesame seeds and tamari, and finish with lemon zest before serving.
4. Kale & Strawberry Salad with Tahini Dressing (8g protein, 200mg calcium per serving)
Ingredients:
2 cups chopped kale (rinsed and dried)
1/2 cup sliced strawberries
2 tbsp pumpkin seeds (dry roasted in a pan)
1 tbsp tahini
1 tbsp lemon juice
1 tsp honey
1 tbsp spring water (to thin dressing)
Directions: Massage kale with a little lemon juice for 2 minutes 1 Then toss with strawberries and pumpkin seeds 2 Whisk tahini, honey, lemon juice, and water, then drizzle over salad.
Blend all ingredients in a food processor until a sticky dough forms
Then, roll into small balls and coat with extra sesame seeds
Store in the fridge for a calcium-rich, bone-supporting snack
So, what are you waiting for? Dive into these recipe ideas and start reaping the bone-building benefits of Spring's bounty today! Your skeleton and your taste buds are sure to be delighted
Are you settling for a health plan that doesn't actually work?
Too many men accept declining energy, chronic stress, and nagging health issues as "normal" while navigating a healthcare system designed for generalized solutions. But let’s face it traditional healthcare isn’t cutting it.
When was the last time your health provider dug deeper than surface-level symptoms?
If you’re ready to stop accepting subpar health and start thriving, the DNA4Men program is here to change the game. Tailored specifically to the unique challenges men face, DNA4Men doesn’t just react to illness; it equips you to take control, uncover hidden risks, and optimize your life.
Why DNA4Men is the program you’ve been waiting for:
Advanced Testing: Gain deep insights into your health with tools like DNAging PREMIUM, DNA Gut 360 PREMIUM, and full metabolic panels to uncover the root causes of your symptoms.
Personalized Care: Experience tailored solutions and comprehensive support with five clinical visits, two telemedicine follow-ups, and actionable strategies to address fatigue, mental fog, low testosterone, and more Targeted Results: Improve gut health, balance hormones, reduce inflammation, and enhance resilience to stress for sustainable, long-term vitality.
Ignoring your health doesn’t make the problems go away. It’s time to demand better DNA4Men offers a transformative, proactive approach to health— because one-size-fits-all is never good enough. Your future self will thank you.
DNA4MEN LEARN MORE
DNA4WOMEN
Why is women’s health still an afterthought in modern medicine?
For centuries, women’s unique health needs have been sidelined in a system built around male physiology. The result? Misdiagnoses, untreated conditions, and a reactive approach that leaves millions of women without the care they need.
It’s time to demand better. By combining advanced tools like the Dutch Complete hormone test, GUT 360 microbiome analysis, and full metabolic panels, this program doesn’t just identify symptoms it uncovers and addresses their root causes.
Why DNA4Women is the program you’ve been waiting for:
Comprehensive, Personalized Insights: Uncover the root causes of health issues with advanced testing tools like the Dutch Complete and GUT 360 tests, providing actionable insights into hormonal, metabolic, and gut health
Tailored Care and Expert Support: Receive personalized hormone treatments and actionable strategies with ongoing guidance through four clinical visits and two telemedicine follow-ups
Proactive Wellness for Lasting Results: Optimize hormonal balance, improve gut health, and reduce risks for chronic diseases with a precision approach designed to support your unique biology and long-term well-being
This is more than just a healthcare plan it’s a wake-up call Women deserve precision care that acknowledges their unique biology and empowers them to thrive DNA4Women is the solution to a system that’s failed women for too long Are you ready to be part of the revolution?
UNLOCKING THE BODY’S STORY THROUGH THE EYES
By Jessica Halpern, DipHIr, CCI, INHC, API
The eyes are far more than the windows to the soul they are powerful messengers of the body’s inner health The iris of the eye has a reflex connection to every organ and tissue of the body by way of the nervous system and can, therefore, serve as a direct reflection of the body’s internal condition
As an iridologist, I specialize in studying and analyzing the intricate patterns, colors, and structural markings of the iris, sclera, and pupils of the eye to gain insight into the body’s physical constitution, inherited traits, and potential areas of imbalance.
Through iris analysis, I can observe how various organs and their systems are inherently functioning, identify potential weaknesses, and uncover the influence of unresolved emotions that may be contributing to physical discomfort The eyes reveal where you have come from, where you are now, and where you may be headed in terms of overall health allowing us to get ahead of potential issues and foster long-term wellness
What makes iridology so remarkable is its ability to tap into your body’s unique genetic story The structure and color of your eyes can reveal tendencies that trace back as far as three generations, giving us powerful insight into your body’s natural strengths and nurture points
By analyzing the iris, I can help you understand areas of resilience within your body as well as the areas that may need additional care and support Iridology does not diagnose or treat diseases, but it serves as an invaluable assessment tool, helping to uncover underlying imbalances that may be impacting your well-being In addition to analyzing the physical body, the eyes also communicate messages about your emotions, personality, and overall vitality often shedding light on the connection between emotional health and physical health This holistic approach empowers you to be proactive about your wellness, encouraging lifestyle adjustments that align with your body’s natural needs
To provide the most comprehensive care, I combine my iridology assessments with cutting- edge genetic testing through The DNA Company. The DNA 360 test offers unparalleled insight into your genetic blueprint By merging the detailed story told through your eyes with the science-backed data from The DNA Company, I am able to create a highly personalized roadmap for optimal health
Your eyes hold the map and your DNA holds the key together this information can unlock the path to vibrant health, giving you the power to take charge of your wellness journey
Visit: https://myeyeread com/
TIMING IS EVERYTHING: A PHARMACIST’S GUIDE TO SAFELY COMBINING SUPPLEMENTS AND MEDICATIONS
By Dr. Gabrielle Gutierrez, PharmD, CFGP | The DNA Company
In the pursuit of optimal health, many individuals turn to dietary supplements alongside their prescription medications While supplements can be beneficial, they are not without risks especially when taken without regard for proper timing and potential interactions
As pharmacists, our job is ensuring medication safety, and believe it or not, that often means recommending fewer not more medications or supplements More substances in the body mean greater potential for interactions, metabolic overload, and even unintended health consequences
However, as a patient myself, I understand why many turn to supplements When you’re not feeling well and something natural seems to validate your struggle or provide symptom relief, it’s tempting to try it But more isn’t always better Instead, a personalized, functional genomics approach can help prioritize the right supplements at the right time for maximum safety and effectiveness
Understanding How Your Body Processes Supplements and Medications
Your liver plays a central role in processing both medications and supplements, primarily through detoxification pathways such as CYP450, CYP1A1, CYP3A4, GSTM1, COMT, and MTHFR. Genetic variations in these pathways determine how efficiently you metabolize toxins, hormones, and pharmaceuticals. Overloading these detox pathways especially with high-dose supplements can disrupt balance rather than enhance detoxification
For example, studies show that polymorphisms in the CYP450 enzyme family, which includes CYP1A1 and CYP3A4 significantly impact drug metabolism, which can lead to:
Reduced medication efficacy (if the drug is cleared too quickly)
Toxic accumulation (if clearance is impaired)
Unexpected interactions with dietary supplements that either induce or inhibit these enzymes
This is why precision medicine is so valuable Instead of guessing which supplements might work, genetic insights help us prioritize interventions that address root causes My approach? Low and slow introducing one targeted supplement at a time while ensuring it doesn’t interfere with essential medications
Common Supplement-Medication Interactions & Timing Considerations
St. John’s Wort & Prescription Medications
• Interaction: St. John’s Wort induces CYP450 enzymes, which can accelerate the breakdown of medications like antidepressants, birth control pills, and blood thinners, reducing their effectiveness
Source: https://pubmed ncbi nlm nih gov/18214849/
Safety Concern: Generally safe, but immunocompromised individuals should consult a healthcare provider before use due to potential risks
Interaction Concern:
Caution when taken with immunosuppressants (e g , corticosteroids, biologics, chemotherapy drugs)
May alter antibiotic efficacy, requiring adjustments in timing for co-administration
Source: PMC – Probiotics and Drug Interactions
CoQ10
Interaction Concern:
CoQ10 is chemically similar to vitamin K and may interfere with warfarin (blood thinner), potentially reducing its effectiveness and increasing the risk of clot formation
This interaction is reversible when CoQ10 supplementation is stopped
Source: NCBI – CoQ10 and Warfarin Interaction
Vitamin K & Warfarin
Interaction: Vitamin K directly opposes the effects of warfarin (Coumadin), increasing clot risk
Recommendation: Maintain a consistent intake of vitamin K while on warfarin and monitor international normalized ratio (INR) levels with your provider
Interaction: Iron supplements can interfere with levothyroxine (Synthroid) by binding to it in the stomach, making it harder for your body to absorb the medication. This can lead to poor thyroid regulation and less effective treatment for hypothyroidism
Source: https://pubmed ncbi nlm nih gov/25040647/
A Smarter, More Personalized Approach to Supplementation
Rather than self-medicating with multiple supplements, a functional genomics approach helps identify:
How your body metabolizes specific nutrients and medications
Which detox pathways need support and which don’t
The safest, most effective supplements based on your genetic profile
Pharmacogenomics test! Know which medications are safe for you!
By focusing on what your body truly needs, we can reduce supplement overload, minimize interactions, and ensure medications remain effective While supplements can be beneficial, they are not risk-free especially when combined with medications making proper timing and spacing crucial As both a pharmacist and functional genomics practitioner, I advocate for a less is more approach, using precision medicine to optimize wellness safely, maximizing benefits while avoiding unnecessary risks
References n G, Kumar DK, Adithan C Distribution of genetic of genes encoding drug metabolizing enzymes & drug a review with Indian perspective Indian J Med Res 65
ain A, Hubbard MA, et al Clinical assessment of ed herb-drug interactions in humans: effects of milk ohosh, goldenseal, kava kava, St John's wort, and Mol Nutr Food Res 2008;52(7):755-763 fr 200600300
man DR Risk and safety of probiotics Clin Infect Dis 2(Suppl 2):S129-S134 doi:10 1093/cid/civ085
P, Keenaghan M Coenzyme Q10 In: StatPearls (FL): StatPearls Publishing; January 30, 2024
tein R, Kurnik D, Almog S, Halkin H Warfarin and e in the era of pharmacogenetics Br J Clin Pharmacol 170 doi:10 1111/j 1365-2125 2010 03672 x
diveloo T, Leese GP Drugs that interact with n observational study from the Thyroid Epidemiology, esearch Study (TEARS) Clin Endocrinol (Oxf) 141 doi:10 1111/cen 12559
Our Provider Partnership Program sets practitioners and clinicians up with the education, tools, and VIP level support they need to successfully integrate functional genomics and our revolutionary suite of testing into their practice With a patient’s genetic blueprint and access to additional functional testing, you can offer a personalized precision approach to health and longevity for those you serve
In this program, we start with The DNA University (DNA-U) This fully accredited course, centered around the newly recognized area of functional genomics, helps providers uncover the individual blueprint of each treated patient
Upon successful completion of the course, you are assigned the Certified Functional Genomics Practitioner (CFGP) designation after your name for professional use. CFGP is the new and recognized standard for functional genomics. This sought after designation demonstrates both prestige and expertise in your clinical area of practice This commitment to your own continuing education proudly displays dedication to your field, and more importantly, to your clientele This can boost your reputation and exposure to new clients
At The DNA University, our founders, CSO, and other industry thought leaders cover the functional interpretation of genetics and genomics We know that genomics and its study is the new frontier and likely how all medicine will be practiced one day Because of that, and the constant need for science to be up to the moment accurate, we provide a lifetime access to The DNA University, and to our published papers and materials This gives you exclusive access to new training modules as they become available
To help you support your practice, and to assist in the expansion of your revenue, we create, develop, and update the libraries keeping you at the bleeding edge of functional genomics Achieving certification gives you confidence that your knowledge and abilities meet recognized standards With The DNA Company as your chosen partner, all DNA-U students have private access to monthly webinars, hosted by our faculty. A dedicated student inbox is monitored to ensure any questions you have throughout the process are answered by qualified medical professionals and scientists In addition to the phenomenal connective tissue to our community and faculty, we design and provide product brochures and information decks that are available in the student resources area so you can present professional materials for patients visiting your clinic or for use on social media or in email marketing campaigns Not only does DNA-U set you up for success, but it also provides continued access to grow your business and build your brand
HOW CAN YOU GET STARTED?
Links to get started on your path and enroll today: The DNA-U Certification & Mastery Bundle (thednacompany com) Only DNA-U graduates are invited to create a Wholesale Provider Account upon successful course completion This account is only available for medical and wellness professionals that are accredited through DNA-U or have a recognized designation or medical license qualifying them to provide our testing and lifestyle recommendations to patients
STEP 1: REGISTER FOR YOUR WHOLESALE PROVIDER ACCOUNT HERE
Answer YES or NO to the NPI # and then click "Get Started" at the bottom right and complete all forms We will send you a confirmation email of your registration
STEP 2: LOGIN TO MANAGE PATIENTS, ORDER TEST KITS, AND VIEW RESULTS.
Go to: https://clients thednacompany com/login aspx (your wholesale portal) and sign in with the username and password you created If you have set up multiple practitioners on the account, the PRACTICE access will be the primary access and the PHYSICIAN access will be used by each practitioner so that patient records can be separated as needed Go to "Orders" on the left side menu and “Submit New Order” to fill out the order form
You will receive a New Provider Welcome Email from our clinic support team once your account is approved. This email provides additional information about the products and services available through the account along with all pricing sheets You will have a dedicated support team who are available to answer questions, assist you with navigating your account, processing orders, or accessing testing results in the system.
Through your account, you will order testing and supplements at wholesale prices The account is intended to work best when you charge your patient the retail price and take payment directly from them, either through your online store or in person Once you’ve collected payment, you can generate a new order You can have the order shipped to your clinic or directly to your patient. You pay The DNA Company the wholesale price, giving you a margin on each product as profit Many providers also choose to stock kits if they are running a brick-and-mortar clinic or including testing in their packages and programs
MORE INFORMATION ABOUT THE WHOLESALE PROVIDER ACCOUNT:
WHOLESALE, SRP & SHIPPING INFORMATION
Link to view current tests and pricing: DNAco Products -Clinicians - August 2024.pdf Link to view current Black Label Supplements and pricing: Black Label Supplements Each test and supplement has a wholesale price and a suggested retail price, giving you a built-in profit margin
For example: Wholesale DNA kits are $349 USD, suggested retail is $499 USD, shipping within the United States is $29 USD per kit, which includes a return postage paid envelope to the lab.
For all addresses outside of the United States, you will see the shipping amount when an item is added to the cart. For international orders, one-way shipping is charged upfront, your patient is responsible for return postage back to the US-based lab along with any applicable duties and taxes We always recommend using a carrier that provides tracking on the return so that your patient has peace of mind knowing it is received by the lab
KIT REGISTRATION PAYMENTS
Each test will include a clear set of instructions so the patient can perform the test at home and register the kit ID to create an account. Please tell your patient that they must register their kit barcode and create an account prior to returning their sample to the lab A QR code is located inside the kit box and instruction card; it contains important information on the test ordered If you would like an electronic version of any of the test kit instruction manuals, we can provide it to you
All orders are paid in full at the time the order is placed and are non-refundable once shipping has taken place You can visit our website and review all our company policies.
LAB PROCESSING
We have multiple lab partners within the United States, depending on the test ordered, processing times vary Our lab address is printed on the instruction card enclosed in the kit and we have a dedicated clinic support team if you have any questions You can also monitor the status of the DNA 360 results from your portal
Now that your Provider Application and Training is complete, you are equipped to provide the highest level of patient care, our team is here to support you, and we wish you all the best in your future success!
A MASTERCLASS IN YOU
Are you tired of outdated advice and one-size-fits-all solutions when it comes to women’s health? DNA Talks SheSummits 2025 is here to change the game. This clinician-led education summit series is designed to tackle the real issues women face, from hormonal health to mental well-being, and empower you with evidence-based knowledge that truly makes a difference.
May 20 - 22, 2025
Nov 18 - 20, 2025
PRODUCTS & AFFILIATES
Your go-to page for discovering exclusive deals, discount, and the latest recommendations about health and wellness. This section connects you directly with trusted brands offering exceptional value.
Each link featured here has been carefully curated to provide our readers with meaningful benefits, unique discounts, and reliable products or services Explore, click, and enjoy the perks while supporting the magazine's mission to bring you quality content.
LIQUID B
DNA Liquid B is a breakthrough in the det management of cancer This innovative method cancer signals in the blood, offering professionals a powerful tool for early detection evaluation, and monitoring for potential recurrenc $22
PGX is a state-of-the-art DNA test that redefines how you approach healthcare With PGX, you'll confidently navigate the selection and dosage of medications, ensuring they align seamlessly with your genetic profile. No code required.
Our Longevity Bundle includes the DNA 360 Functional Genomics Test and the DNAging Epigenetic Test, providing a deep dive into your genetic and epigenetic makeup No code required
ARE YOU READY TO TAKE CONTROL OF YOUR BREAST HEALTH BEFORE IT’S TOO LATE?
Take charge of your health with $50 off the DNA Breast 360 testyour personalized guide to understanding breast cancer risk and prevention. Plus, gain exclusive access to a curated Women’s Health Content Playlist packed with expert insights on hormonal balance, breast health, and actionable strategies for long-term wellness No code required – discount automatically applied at check-out!
AFFILIATE LINKS
GOT MOLD
Breathe Better, Live Better - Discover the Power of the Got Mold? Test Kit
Your health starts with the air you breathe, and unseen mold could be silently compromising it. The Got Mold? Test Kit makes it easy to detect hidden mold problems in your home or workspace without expensive inspections In just a few simple steps, you’ll get lab-verified results that reveal exactly what’s in your air Armed with this information, you can take targeted action to create a safer, healthier environment for you and your family
Use code DNACO10 for 10% OFF your purchase
RADICAL ROOTS
Complete Spectrum Support for Inflammation and Pain
Relief by Radical Roots is more than just CBD - it’s a complete spectrum hemp formula designed to address inflammation, pain, and overall recovery at the root. Powered by premium hemp, traditional Chinese herbs, and a full cannabinoid profile, this blend works synergistically to calm the nervous system and restore balance. Unlike isolated CBD products, Relief harnesses the full therapeutic potential of the hemp plant, amplifying absorption and results Whether you’re dealing with chronic inflammation, soreness, or everyday aches, this formula helps you move, feel, and live better
Use code DNACO for 15% OFF your order
HYPOAIR
Breathe Easier and Safer with Mold Guard™
Mold Guard™ is your proactive defense against hidden mold and bacteria giving you cleaner, safer air where you live and work Using a powerful blend of natural botanicals and cuttingedge technology, it helps prevent mold growth on surfaces and in the air before it becomes a problem. Unlike typical sprays or treatments, Mold Guard™ works continuously, helping to maintain a healthier indoor environment without harsh chemicals. It’s simple to use, safe for your home, and effective for those who care about respiratory health and long-term air quality
Use code DNACO for 10% OFF your order
JOOVV
Unlock Your Body’s Natural Power with the Joovv Solo 3.0
The Joovv Solo 3 0 delivers advanced red and near-infrared light therapy designed to boost cellular energy, improve recovery, and enhance overall well-being. Clinically studied wavelengths help optimize mitochondrial function, leading to better performance, healthier skin, and reduced inflammation. Whether you're looking to recover faster, sleep better, or simply feel more vibrant, the Joovv Solo brings professional-grade light therapy right into your home Its modular design fits seamlessly into any space, allowing you to customize treatments for your needs
