The DNA Talks Digest 2024 - Winter Edition by The DNA Company - US

CARBON 60: THE MIGHTY MOLECULE THAT MAY TRANSFORM YOUR ENERGY AND OVERALL WELL-BEING

DECODING BEAUTYSPAN: THE SCIENCE OF AGING BEAUTIFULLY

Ken Swartz, MS

Jennifer Pearlman, MD, CCFP, NCMP, FAARM, ABAARM, CFA

Dr Lara Varden, PhD, BCHHP, LEHP, CFGP, CFNC

Exclusive interview with Kashif Khan by Tracy Wood

Maryon Stewart, BEM

Welcome to the newest edition of the DNA Talks Digest.

We are thrilled by the outpouring of positive feedback from you, our valued community, to our inaugural edition! Our goal in sharing all of this information through the DNA Talks Digest, is for us to provide you with a gateway to understanding how the power of genetic science and personalized medicine is transforming and extending lives We are thrilled to have you embark on this exciting journey with us, month after month a journey into the intricate world of Functional Genomics where we help you weaponize your individual DNA Functional Genomics really is the future of health and provides remarkable insights into the potential of customized care

In an era where one-size-fits-all approaches are rapidly becoming relics of the past, personalized medicine offers hope, precision, and empowerment. Each of us carries a unique genetic blueprint, and within it lies the key to unlocking optimal health, tailored therapies, and proactive wellness strategies. Whether you are passionate about the latest breakthroughs in genome editing, curious about how genetics influences lifestyle choices, or seeking answers to personal health challenges, this magazine is designed to inform, inspire, and empower you

The recent election has brought concerns for many in the Women’s Health space For us at The DNA Company – US, we have renewed hope for women's healthcare Our mission will be to focus on advancing equitable, accessible, and personalized care With The DNA Company’s leadership, we will be active in executing policies aimed at prioritizing women's health. Our growing commitment to addressing longstanding disparities and expanding research into conditions that disproportionately affect women, will be actioned through new and specific testing to come in the New Year. This moment represents a promising step forward, as our enlightened community and our functional practitioners work together to ensure that every woman has access to the care she needs to thrive.

Our pages are filled with insightful features from Key Opinion Leaders and experts, compelling patient stories, and cutting-edge testing This issue spotlights the transformative impact of genetic testing, the role of lifestyle modifications in epigenetics, and ethical discussions that will shape the future of personalized care We also offer practical advice on integrating genetic insights into your daily life from diet and fitness to mental health and beyond

At DNA Talks Digest, we believe knowledge is power. By understanding your genetic blueprint, you can make informed decisions that align with your unique biology and aspirations. Our mission is to bridge the gap between groundbreaking science and everyday life, making the tools and knowledge of the genomic revolution accessible to everyone.

Thank you for joining us in this groundbreaking exploration Together, let us decode the mysteries of our DNA, embrace the possibilities of personalized medicine, and chart a healthier future one individual at a time

Here is to discovering the unique blueprint of you!

CEO, The DNA Company & Founder of DNA University

THOUGHT LEADERS DRIVING THE CONVERSATION

DR KRISTA KOSTROMAN, ND, BCS, CFGP

Chief Science Officer The DNA Company

DR LARA VARDEN, PHD, BCHHP, LEHP, CFGP, CFNC

Dean of Students The DNA University

Certified Functional Genomics Practitioner

Co-Founder & CINO The DNA Company

Chief Medical Officer The DNA Company

BHRT Specialist and Autoimmune Specialist

Co-Founder The DNA Company

BRYCE WYLDE, BSC (HONS), RNC, DHMHS

DR. BOYCE BERKEL, MD

KASHIF KHAN

JUSTIN HARRIS, CFGP

DR STEPHANIE NIELSEN, PHARM D , CCN, CFGP

LYNN ANGEL, CFGP

FELICIA BRUNO Certified Functional Genomics Practitioner Director for Genomic Fitness The DNA Company

Each contributor brings their unique expertise, from cutting-edge research to practical applications in genomics, offering readers valuable insights into the future of healthcare. Together, this diverse roster of experts provides actionable knowledge to help individuals optimize their health.

Ken Swartz, MS

DR JENNIFER PEARLMAN, MD, CCFP, NCMP, FAARM, ABAARM, CFA

MARYON STEWART, BEM

BARBARA BATES, MASC, RNCP, ROHP

DR TRACEY STEADY HARDCASTLE, DACM, MSTOM, CFGP

AMANDA-JO WILT, CFGP

DR TIM JACKSON, DPT, CFGP

DR ADILIA SAPP, ND

DR TIFFANY SMITH, DNP, APRN, PMHNP-BC, MASTER AROMATHERAPIST Founder and Chief Science Officer of C60 Purple Power Regenerative Aesthetic Medicine and Women’s Health Expert CEO and Founder of Femmar

Certified Functional Genomics Practitioner

Director for Black Label The DNA Company

Certified Functional Genomics Practitioner

BRAIN DETOX

By Bryce Wylde BSc (hons) RNC DHMHS | The DNA Company

of us hardly dreamed of them ourselves. But what we once suspected or heard rumored, we now know for certain: our air, our water, our food, and many of the everyday objects we employ are a constant threat to our health and safety A few decades ago, you rarely heard the word toxin If something could poison you, you called it poison Everyone knew what poisons were They were the products labeled with a skull and crossbones: the caustic lye in the garage, the bleach in the laundry room, the bottle of iodine in the medicine cabinet, and maybe even DDT pesticide, and the once frequently discussed topic of acid rain (why is that no longer a thing?) Today, toxins are becoming famous in their own right, hitting the six o'clock news on a regular basis: bisphenol A (BPA) in plastics, radiation from phone cell towers, radon gas seeping into your basement, and pharmaceuticals and radionuclides in our drinking water just to name a few

It’s no wonder that late-night infomercials deliver urgent, lowbudget warnings about toxins and then offer us the miracle of detoxification. Most of us at least nod in recognition when toxins are mentioned and now most are quite familiar with the concept of detoxification being good for us. Detox, as a natural health practitioner may refer to it, is the latest fad Even top celebrities are big advocates of it It’s a painless process normally requiring little more than following the product directions on a bottle and eating, say, beet and carrot juice, for a month That is a tremendous value at $299 99 plus local taxes where applicable Actually, most of those don’t work sorry

We’ve all splashed ourselves a few times with a corrosive cleaner while cleaning the toilet, and some may share their neighborhood with a nuclear reactor, while still others drink municipal tap water all our lives, and yet somehow we’re all still here So, why do we need to consider detoxification? At the end of the day, it is easy for the topic of toxins and detoxification to sound like new-age vagary. The concept is often elevated to news status by a hungry media; bowel flushes and lymph cleanses seem like the brain hatchlings of tree-hugging vegans and fringe health fanatics. In the face of this flood of information, what are we supposed to do, put on a radiation suit when someone walks into the office eating a non-organic apple? The idea is not to panic or become fanatical The best reason I can give you to consider a valid detoxification prescribed by a clinician who knows what they’re talking about (or at the very least a health food store clerk with some credentials) is based on what I refer to as “the human health threshold ”

It’s simple Although you’ll be happy to learn that most of us detoxify every second of every day – and quite well on our own, thanks to our liver, kidneys, and bowels – some of us do a far better job than others What is the difference? It’s a combination of our individual, personal threshold Let me explain

My experience with my patients has brought home to me that human health consists of an interplay of variables that include our genetics, our environment, our toxic load, our stress accumulation, our nutritional and emotional states, our exposure to microbes, our level of fitness, and a plethora of other factors Each of us has an individual ability to cope with these factors The limit of that ability – the point at which, if we exceed it, our health fails – is our human health threshold

If we imagine a thermometer that registers the sum of all these interacting factors, our health threshold is the boiling point. By analogy then, like water, think of the human health threshold as 100 degrees Celsius But the capacity for managing the various influences that affect our health is different for each of us because for some, stress, for example, accounts for 20 degrees, where for others, it may account for 50 degrees For some, diet may account for 30 degrees, and for others, it may be 70 degrees due to a genetic predisposition for poor carbohydrate metabolism Nonetheless, when we are pushed past our individual thresholds, we are no more able to remain healthy than water can prevent itself from boiling when it’s heated to the boiling point Today, many of us run so dangerously close to that threshold that we increase the probability of an early decline in the functioning of our bodies We may be living longer than the generations who came before us, but we are living longer with chronic disease and discomfort We are becoming toxic Our health “temperature” constantly rises with our increasing levels of stress, poor diet, environmental burdens, and exposure to toxins, just as the mercury in a thermometer slides up in response to an increase in temperature

Since the Second World War, an estimated 85,000 synthetic chemicals have been registered in North America Toxicological screening data are available for just 7% of these chemicals This means that testing on humans can detect only one in 14 chemicals Some studies on toxins found in the umbilical cord blood of 10 newborns discovered 200 trace chemicals Translation: we actually may be looking at 2,800 synthetic chemicals in one small body before it’s even born Right from the get-go, we’re born into a toxic world already full of toxins Shampoo, shaving cream, lip gloss, hand soap, dish detergents, laundry detergents, moisturizing creams, perfumes, air fresheners, cosmetics, and deodorants – in our heart of hearts, we know these useful little additions to our daily lives start out as nasty raw materials, but we don’t like to think about it Dyes and pigments, rubber, the fabrics that make up our clothing, the paint on our houses, the tube of glue in the kitchen drawer – we know they started out in places with chimneys belching sulphur oxides, nitrogen oxides, volatile organic compounds, particulate matter, carbon monoxide, sulphuric acid, carbon dioxide, and dioxins We know – but we don’t want to know But what is the organ most vulnerable to all these toxins? Your brain!

Cerebrospinal fluid is a clear liquid surrounding your brain and spinal cord and it moves through a series of channels that surround blood vessels managed by specialized cells in your brain called glial cells These cells don’t think, they detoxify This is called the glymphatic system If toxins accumulate faster than the glymphatic system can rid of them, they can damage and even kill brain cells

The best way to manage neuron depleting toxins – like solvents, drugs, radiation, paints, industrial chemicals, and heavy metals –is to avoid them in the first place, if possible

Lifespan is the length of time you’ll spend on this earth regardless of how healthy you’ll be And we all want to live longer, but we all want to age slower We all want to live as healthy a life as possible This is known as healthspan – your longest life spent in optimal health Brainspan, however, is living your longest life spent in optimal health with the best brain possible One way to optimize brainspan is to better manage glymphatics and brain detoxification

Detoxification, or detox, refers to your body’s ability to neutralize the harmful effects of synthetic chemicals in the environment, metabolize prescription medication, or even manage cellular debris as a consequence of day-to-day life Detoxification is like dealing with the trash in your home The first step is usually to discard it in the waste bin under your sink The second step is to store it in your garage until collection day Step three is to place it curbside for the city garbage truck to come by for the “waste disposal technicians” to pick up

Phase I of our body’s detoxification process is the first-line of defense against all environmental toxins, including pesticides, herbicides, pollutants, solvents, pharmaceuticals, and even processing certain natural medicines and supplements. In this phase, our liver makes specific enzymes that “take the garbage to the garage” for our body. Even naturally occurring chemicals that our own body creates – such as waste products and end metabolites as a result of hormone formation – get detoxified in Phase 1

A key point is reached between Phase I and II, where harmful free radicals are formed as a result of Phase I activity but are transformed to harmless water by antioxidants ingested in our diet It is important to note that increased Phase I detoxification without increased detoxification in Phase II can lead to the formation of intermediates that may be more toxic than the original toxin! To use a trash example, you might be great at putting the garbage in the garage, but if you regularly forget to put the trash at the curb, you’ll soon be facing a major contamination issue in your home

Phase II detoxification follows phase I Toxins are transformed into water-soluble substances that the body is then able to eliminate through the urine or in the feces through the bile Phase II enzymes of detoxification are involved in what is known as the conjugation or binding of toxins, which makes them more extractable from your body

Being an optimal detoxifier requires a great glymphatic system in your brain and a balance in Phase I and II liver detox systems More often than not, detox pathways need help In this article, you’ll learn how to support detox and avoid toxin exposure

Science has discovered that one of the advantages centenarians have is that they are super detoxifiers

A family of genes known as the glutathione s-transferase (GST) family of genes is responsible for making glutathione the antioxidant that is paramount in your ability to detoxify.

The GST family detoxifies many environmental toxins. The list is long and includes volatile solvents like glues, aerosol, paints, industrial solvents, and gasoline, as well as cleaning fluids, herbicides, fungicides, and heavy metals such as mercury, cadmium and lead. The GST family is also responsible for detoxifying endogenous toxins that are produced by the body as a response to stress, exercise, hormone metabolism, and a variety of health disorders

Some of us detoxify much more ineffectively than others Where you can’t change your DNA, the great news is that you can modify your genetic expression This means there are things you can do to support detoxification once you understand your DNA A healthier tomorrow starts with a DNA360 test today and you can learn more about this at www thednacompany com

Unless you want to be the filter, put filter technologies to work The number one way to reduce toxic exposures in your home is to have a good water filter City water may be safe, but it isn’t pure Throughout North America, there is a relaxing of regulations on pesticides and industrial toxins that run off into the water supply Sadly, this has led to a huge rise in exposure to all kinds of toxic chemicals that harm your brain Reverse osmosis is the best water filtration system, removing everything and leaving virtually nothing behind but pure H2O

Filter the air you breathe Furniture is loaded with flame retardants, household items such as shower curtains emit volatile organic compounds (VOCs), and plastics leach phthalates Replacing all these items with chemical-free replacements may not be practical A high efficiency particulate air (HEPA) filter can significantly minimize the toxic load on your brain from these common household items If you can afford it, also consider a HEPA vacuum Just like with water, you can be the filter or you can choose to have technology do it for you

Reduce your exposure to mercury. If you have silver fillings in your mouth, remove them! These are amalgams and are made up of 25% silver; 25-35% blend of copper, zinc, and tin; and shockingly 40-50% mercury! When you grind your teeth in the process of chewing your food, mercury is being released into your system.

A less common way you get exposed to mercury is breathing mercury vapor This can happen when mercury is released from a container, or from a product or device containing mercury that breaks If the mercury is not immediately contained or cleaned up, it can evaporate, becoming an invisible, odorless, incredibly toxic vapor

The good news is that a potent antioxidant naturally found in your liver called glutathione helps to clear brain toxic mercury By supplementing with alpha lipoic acid, N-acetyl cysteine, and selenium, you can help your body make more glutathione to deal with mercury as well as a whole host of other toxins

As I’ve mentioned above, detox is as much about avoiding toxins in the first place Organics is a $50 billon industry We are spending up to 60% more for things we believe are healthier and less toxic And for good reason Buying organic in many cases will minimize the brain toxic effects of pesticides, fertilizers, hormones, antibiotics, dyes, solvents, irradiation, and genetically modified organisms (GMOs)

Not to mention, organic farming is more sustainable for the environment. Fewer pesticides are released into the environment. Some of those pesticides can taint local water sources or harm local aquatic wildlife. Studies also show that organic farms produce less waste and use less energy.

But here’s the deal not all organic is equal Look at your labels 100% certified organic indicates the product contains 100% organic ingredients The use of the term certified organic indicates the product contains a minimum of 95% organic ingredients and up to 5% of ingredients may be nonorganic agricultural products The use of the term certified natural indicates the product likely doesn’t contain artificial ingredients or added color, but the product may contain antibiotics, pesticides, or other similar chemicals This is basically a bogus and meaningless claim

Eating lots of fruits and veggies daily will support your brain and help it detoxify When it comes to protecting your brain from the toxins found in some non-organics, here is a list that clarifies what you really should buy organic and where you can save some money on conventional produce

Strawberries are one of the most susceptible fruits to bugs and pests, making them prime targets for high pesticide treatment. They are highly sprayed with pesticides. BUY ORGANIC.

Potatoes that are grown above ground are sprayed with pesticides, and the soil they’re grown in is treated with fungicide By buying organic varieties, you avoid both these threats In case you can’t find organic potatoes, try s potatoes; they are usually grown with far less pesticides

When pierced, onions deploy a natural defense system results in a harsh, sulfuric odor and pungent flavor Insects to stay away, which means less of a need for pesticides can safely buy conventional onions

Peppers react to pesticides like a sponge, absorbing chemicals through the skin. Because of this, you won’t be to reduce chemical ingestion by washing or peeling them. organic!

The environmental working group found that 80% o pineapples were completely free of pesticide residues That surprising when you consider the pineapple’s impres defense system: a spiny shell of armor that protects precious, juicy fruit inside Feel good about buying conventio

The avocado’s tough, fortifying skin protects the soft, cre flesh on the inside Thanks to this impressive natural def system, the avocado ranks #1 as the “cleanest” fruit you can conventionally

Leafy green veggies are doused in pesticides to ward off insects Organic growers use methods like non-toxic repellents to keep these vegetables free of pests Definitely buy your salad organic!

Animal products like meat and dairy have high amounts of toxins because of bioaccumulation This refers to the accumulation of larger amounts of hormones, pesticides, and antibiotics that are given to non-organic animals – not to mention conventionally raised livestock have living conditions that are far worse Nonorganic animal products are also from animals fed a diet of genetically modified food Not to mention, pasture-raised cows take up more room and they aren't fattened up with grains, so the process costs a lot more When it comes to any and all animal products, purchase organic only!

Fish grow in the ocean, where it's impossible to know what (if any) pesticides they've encountered, so there are no guidelines for certifying organic seafood – although it is not illegal to use the certification in some cases, there is little control. Because of this, perhaps save your money and buy conventionally raised fish

I would be remiss if I didn’t remind you at this point how important sleep is to detoxification It turns out that glymphatic activity is dramatically enhanced during sleep, while its function is suppressed during wakefulness What’s more, when you optimize sleep hygiene your glymphatics work better

You can’t manage what you don’t measure So, know your numbers!

Look at the environmental working group’s healthy home tips to determine where in your home you may be able to lessen the toxic burden.

When it comes to mercury, look for a test that uses combined samples of hair, blood, and urine to assess the body’s total mercury burden as well as its ability to eliminate it Testing this way helps your clinician to understand the magnitude and source of mercury exposure, as well as if additional support is needed in the process of mercury detoxification

Here’s to a healthier, sharper, cleaner brain!

BOOSTING YOUR MEMORY

By Maryon Stewart, BEM | Femmar

Do you forget what you are saying in midsentence, what you went into a room for, or where you put your car keys? You are not alone It’s one of the commonest symptoms of menopause

Feeling like you are losing your memory at midlife can be very frightening, especially if you think it’s permanent. Many women secretly wonder if these “senior moments” are the beginning of early-onset Alzheimer’s disease or dementia and are truly freaked out

As well as hot flashes and a whole host of other symptoms, many women experience brain fog during menopause, impacting their daily lives and overall well-being But the good news is that it can be reversed

What Is Brain Fog?

Brain fog refers to a state of cognitive confusion, difficulty concentrating, and memory lapses It is characterized by a sense of mental cloudiness, making it challenging to think clearly, stay focused, and retain information. Women going through menopause often describe it as feeling spaced out or having a fuzzy brain

Causes of Brain Fog during Menopause

Hormonal Changes: The primary cause of brain fog during menopause is fluctuating hormone levels, particularly estrogen, which plays a vital role in cognitive function As estrogen levels, decline women commonly experience memory lapses and reduced mental clarity.

Sleep Disturbances: Menopause is often accompanied by sleep disturbances, such as insomnia or night sweats Poor sleep quality and insufficient rest can directly contribute to cognitive impairment and exacerbate brain fog symptoms.

Stress and Anxiety: Menopause can be stressful for women, as it involves significant hormonal and physical changes. Stress and anxiety profoundly impact cognitive function and can intensify brain fog symptoms

Tips on How to Manage Brain Fog

Healthy Lifestyle Habits: Adopting a healthy lifestyle can positively impact brain function Regular exercise, a balanced diet, and sufficient sleep optimize cognitive performance Exercise promotes blood flow to the brain and releases endorphins that enhance mood and mental clarity.

Replace Estrogen: Replacing depleting levels of naturally occurring estrogen by adding phytoestrogens into your diet is key. Phytoestrogens can be found in food containing soy, such as edamame, tofu, soy milk and yogurt, and organic flaxseeds There are also medically researched supplements that are phytoestrogen rich The trick is to include small amounts of phytoestrogens throughout the day as the receptor sites don’t stay full for very long

Cognitive Exercises: Engaging in mentally stimulating activities, such as doing puzzles, reading, and learning new skills, can help sharpen cognitive abilities These exercises challenge the brain and improve memory, concentration, and problem-solving skills.

Stress Management: Incorporating stress management techniques into daily life can alleviate brain fog symptoms Practices like meditation, deep breathing exercises, and mindfulness can reduce stress and promote mental clarity.

Prioritize Self-Care: Menopause is a time of transition that requires self-care and self-compassion Listening to your body, taking breaks, and engaging in activities that bring joy and relaxation can alleviate brain fog and improve overall well-being.

PBS is currently broadcasting Maryon’s Menopause Moments – short mini-programs about different aspects of menopause – here is the link to the one on Brain Fog

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ENCODED GUT-FEELINGS

By Dr. Krista Kostroman, ND, BCS, CFGP | The DNA Company

As the holiday season unfolds with festive meals and family gatherings, it’s not just the decorations that bring joy Our brain-gut connection plays a key role in influencing both mood and digestion, especially with serotonin, affectionately known as the “cozy” neurotransmitter Interestingly, most of our serotonin is produced in the gut, meaning that while serotonin supports holiday cheer, it also helps your body manage that extra serving of turkey

The human body is a delightfully interconnected set of systems, where each system influences the others in ways that researchers are only beginning to fully understand. Among the many connections being explored is the gutbrain axis While many people intuitively knew this axis existed some may call it a gut feeling it was not until the 1990s that science understood that gut feeling to be the enteric nervous system (ENS) The ENS is a bidirectional communication network between the gut and the brain, influencing both physical and mental health. Key to this conversation is the serotonin transporter (SERT) and how its polymorphism 5-HTTLPR (serotonin transporter-linked polymorphic region) influences serotonin This polymorphism not only affects serotonin levels in the brain, which has long been associated with mood regulation, but also plays a role in gut health.

Serotonin is crucial for regulating mood, fine-tuning attention, and supporting healthy appetite It is produced predominantly in the gut, with approximately 90% of the body's serotonin synthesized in the digestive system, and the remaining 10% in the brain. SERT, a protein expressed by the SLC6A4 gene, helps keep serotonin levels balanced in both the brain and the gut The 5-HTTLPR is a genetic variation that influences how efficiently serotonin is recycled People can inherit either short (S) or long (L) alleles, or a combination of both, affecting how well their body handles serotonin. The short allele doesn’t recycle serotonin as efficiently, leaving more serotonin floating around but less available for reuse The long allele works more efficiently like a recycling machine Your ability to recycle serotonin has profound effects on both the brain and the gut

The influence of the 5-HTTLPR polymorphism in the brain has been extensively studied in relation to mood disorders, stress sensitivity, and emotional regulation

Individuals carrying the short (S) allele are more prone to anxiety, depression, and stress-related disorders compared to those with the long (L) allele This is thought to be due to the decreased ability to recycle serotonin efficiently, leading to altered serotonergic signaling in regions of the brain responsible for emotion regulation, such as the amygdala and prefrontal cortex

Research shows that individuals with the SS genotype may exhibit heightened emotional reactivity and a more pronounced response to negative environmental stimuli (like that one family member you dread seeing every year) In contrast, those with the LL genotype tend to have more resilient emotional responses Moreover, the SS genotype has been linked to differences in neural connectivity Brain imaging studies suggest that those with the short allele have greater amygdala activation when exposed to negative stimuli, alongside weaker communication between the amygdala and the prefrontal cortex, which can hinder effective emotional regulation This may imply that the 5HTTLPR polymorphism not only influences serotonin reuptake but also affects broader neural networks involved in processing emotions and stress

While serotonin’s role in the brain is well known, its lesserknown function in the gut is important In the digestive system, serotonin regulates gut motility, secretion, and sensation A dysregulation in serotonin levels in the gut is now being associated with gastrointestinal disorders such as irritable bowel syndrome (IBS), constipation, and diarrhea Just as individuals with the SS genotype may experience heightened emotional responses to stress, they may also experience gastrointestinal symptoms in response to stress, including bloating, abdominal pain, and altered bowel movements This is partly because stress triggers the release of serotonin in the gut, which affects motility and visceral sensitivity In people with the SS genotype, this can lead to an exaggerated gut response, potentially worsening conditions like IBS

Interestingly, the gut microbiota may also interact with serotonin pathways influenced by the 5-HTTLPR polymorphism Our gut bacteria do not just break down food; they also help regulate serotonin If you have the SS genotype, this interaction might mean that your gut and brain are extra sensitive to both holiday indulgences and stress.

What is the takeaway from this? Better self knowledge so you can better be ready for and more importantly enjoy this holiday season. If you have ever felt emotionally overwhelmed during the holidays whether it’s due to a packed house or that one family member who always pushes your buttons it could be your SS genotype at work Being mindful of your limits and practicing self-care can help you manage those feelings And while sweet treats may feel good in the moment (literally, complex carbohydrates lead to serotonin production) the seesawing of sugar levels can further agitate mood. Grow awareness of what you are eating not only for the sake of your belt, but also how it impacts your mood and ability to enjoy the festivities. For individuals prone to mental health challenges, support from loved ones or professionals can be invaluable during this time

On the digestive front, regardless of your 5-HTTLPR status, overindulgence and absence of regular exercise and sleep can make you more prone to indigestion, overeating, or aggravation of preexisting conditions like IBS Those with an SS or SL presentation may be at greater risk At holiday meals, pacing yourself is key Consider mindful eating practices slowing down between courses or taking a few moments to breathe before diving into dessert Consider front-loading your meals with protein and fiber that will support not only digestion but feelings of satiety You may also want to discuss digestive supports with your doctor Ginger and mint are incredible herbs that support digestive function. Full-spectrum digestive enzymes can support digesting large meals or novel foods Gentle physical activity like post-meal walks can also aid in better digestion, reducing the chances of discomfort.

While we cannot change our genes, we can understand and work with them to improve our well-being By recognizing how your genetic makeup, especially the 5-HTTLPR polymorphism, influences your mood and digestion, you can navigate the holiday season with greater ease Prioritize self-care, stay mindful of how you respond to stress and food, and embrace your delightfully interconnected systems to enjoy the holidays with balance and resilience

References:

1 Hariri AR, Mattay VS, Tessitore A, et al Serotonin transporter genetic variation and the response of the human amygdala Science 2002;297(5580):400-403

Caspi A, Sugden K, Moffitt TE, et al Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386-389. doi:10 1126/science 1083968

2 Canli T, Qiu M, Omura K, et al Neural correlates of epigenesis Proc Natl Acad Sci U S A 2006;103(43):1603316038 doi:10 1073/pnas 0601674103

doi:10 1126/science 1071829

Gershon MD Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans Am Clin Climatol Assoc 2012;123:268-280

Mayer EA, Savidge T, Shulman RJ Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology 2014;146(6):1500-1512

doi:10 1053/j gastro 2014 02 037

Fond G, Hamdani N, Kapczinski F, et al Effectiveness and tolerance of probiotics, prebiotics, synbiotics, and psychobiotics in psychiatric diseases: A systematic review European Psychiatry 2023;30(2):300-309 PMID: 38732599

Yano JM, Yu K, Donaldson GP, et al Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis [published correction appears in Cell 2015 Sep 24;163:258]. Cell. 2015;161(2):264-276. doi:10 1016/j cell 2015 02 047

DECODING BEAUTYSPAN: THE SCIENCE OF AGING BEAUTIFULLY

By Dr Jennifer Pearlman, MD, CCFP, NCMP, FAARM, ABAARM, CFA | PearlMD Rejuvenation

The science of aging is unfolding rapidly Most longevity experts believe that within 15 years we will reach human escape velocity, a time when scientific advancements keeping us young outpace the rate of our aging

The Hallmarks of Aging

The emerging field of longevity has positioned 12 hallmarks of aging, these are both markers and drivers of advancement in age and decline in health Less than 20% of our ageing is hardwired Rather, many hallmarks such as epigenomic alterations, telomere loss, stem cell depletion, mitochondrial exhaustion, inflammation, and nutrient sensing impairment are under the influence of our life choices and habits Factors that ward off these hallmarks hold the promise of extending the years of healthy living or lifespan and are considered geroprotective

Beautyspan and BioAge

It turns out that looking young may be a predictor of living long. There are several important facial features that serve as phenotypic biomarkers of age. The downward descent of the lateral canthus and lateral commissure, the increase in nasal tip to lip height and the appearance of the jowl with sagging submaxillary tissue below the level of the mandible all serve to predict biological age Skin aging is marked by wrinkles, furrows, increased laxity, and dyschromia

Hormones and the Skin

Accelerated skin aging, especially in the peri-oral region, accompanies the menopause transition in woman and is associated with hypoestrogenemia. Estrogen is geroprotective and upholds most hallmarks of aging With menopausal estrogen loss, rapid skin and facial aging often ensues with sudden appearance of peri-oral rhytids, lip aging with volume loss, dryness, pallor, and deep furrows in the marionette area or prejowl sulcus.

A proactive approach to hormonal health including testing and treatment throughout the midlife transition, especially in women, can help to mitigate the rapid age acceleration that otherwise coincides with menopause Systemic bioidentical estrogen prescribed as either transvaginal or transdermal therapy in combination with progesterone is a safe and appropriate option for most low-risk women during this phase Additional consideration to skin health and the role of estrogen or estrogen modulators can boost skin health and rejuvenating effects

A Beauty Diet

Nutritional deficiencies leave telltale signs on the skin and affect our physical appearance From redness to dryness to dark undereye circles, the adage that we are what we eat rings true on our skin. The skin is supplied with as much as 15% of our blood flow with each heartbeat. With increased age, our ability to extract and utilize nutrients from our diet declines, making targeted nutraceutical supplementation an important step to optimizing health beyond our 40s Cosmeceuticals refer to supplements taken to enhance beautyspan and include the following top picks: vitamin D, omega 3, magnesium, vitamin C, beta-carotene, amino acids, and marine collagen

Aging is not inevitable Our hardware can be reprogrammed to be young again Akin to a software update for an old computer, rebooting our system by addressing the hallmarks of aging affords the opportunity to live longer younger As we consider the impact of inflammation, hormones, and nutrition on our skin we can develop a beauty from within approach Healthy beautiful aging defines our beautyspan And the science of longevity is decoding the secrets to achieve this goal.

MANAGING HOT FLASHES NATURALLY

By Maryon Stewart, BEM | Femmar

Heat waves are bad enough when we can control our thermostat. Add hot flashes and night sweats to the mix and it can become impossible to function It is estimated that over 80% of women experience hot flashes at some point in their lives They can occur even before our periods end, and persist for several years after menopause While the exact cause of hot flashes is still unknown, experts believe that the decrease in estrogen levels may impact the hypothalamus, the part of the brain responsible for regulating body temperature

Hot flashes frequency, duration, and intensity vary significantly from person to person. Some individuals may experience several hot flashes throughout the day, while others may suffer from continuous episodes that disrupt both day and night These episodes typically last from a few seconds to several minutes In addition to the sudden sensation of heat, individuals may also experience a racing heart, dizziness, anxiety, and irritability

Night sweats, which are severe versions of hot flashes during the night, can be particularly distressing They can cause individuals to wake up drenched in perspiration, often necessitating a change of pajamas and bed sheets The lack of sleep due to night sweats can lead to chronic exhaustion. Furthermore, many women avoid physical contact with their partners, as it can trigger a hot flash, resulting in feelings of rejection and relationship problems

To alleviate the discomfort caused by hot flashes and night sweats, try these strategies:

When you feel a hot flash coming on, pause your activities and take slow, deep breaths to promote relaxation, which may help reduce the severity of the episode.

Drink a glass of cold water and sit calmly until the hot flash subsides

Consume small, frequent meals instead of large ones, as the heat generated during digestion can trigger hot flashes

Include plenty of phytoestrogens in your diet, including soy and flaxseeds as they fool the brain into believing we have normal circulating estrogen, helping to alleviate symptoms

Wear layered clothing that can be easily removed when you feel overheated. Opt for natural fiber fabrics like cotton to allow your skin to breathe

Keep your bedroom cool at night and have a fan, wet wipes, and a cold beverage readily available by your bedside

Maintain a regular exercise routine, as being physically fit can reduce the frequency and intensity of hot flashes. Refrain from smoking, as research indicates that smoking increases the risk of overheating

Consider using scientifically based supplements such Femmenessence MacaPause, which has been shown to reduce or eliminate hot flashes and night sweats effectively.

And last but certainly not least, tech comes to our rescue Clinical research has shown that wearing the Embr Wave wristband gives you immediate relief from hot flashes and improves the quality of your sleep At the touch of a button, get precisely calibrated cooling sensations to help you find relief and have more control over your hot flashes and related menopause symptoms like night sweats, chills, and disrupted sleep.

You don’t need to suffer from hot flashes or night sweats

The answers to eradicating hot flashes do not happen overnight, but with work they will reduce and stop eventually. It takes some perseverance, but it will be worth it in the end – keep the end goal in sight

Check out my PBS Menopause Moment on hot flashes

Maryon Stewart is often referred to as the pioneer of the natural menopause movement as she and her team have helped hundreds of thousands of women to reclaim their well-being She is the author of Manage Your Menopause Naturally as well as 27 other self-help books Plus, she runs a virtual 6-week online Natural Menopause Solution teaching women how to manage menopause symptoms and reclaim their well-being We are offering a discount of $100 for all readers – use the Discount Code PROAGE100

HOLIDAY STRESS AND THE POWER OF VITAMIN G (GRATITUDE)

By Dr Lara Varden, PhD, BCHHP, LEHP, CFGP, CFNC | The DNA Company

As the holiday season approaches, many of us are filled with anticipation, joy, and excitement However, it’s also a time when stress can bubble to the surface From the pressures of planning and family gatherings to the added financial strain, the holiday season can often feel more overwhelming than merry. One antidote to this stress that has gained attention from both scientists and wellness experts alike is something called "Vitamin G" – better known as Gratitude

Improve

mood and emotional well-being:

Gratitude increases the production of dopamine and serotonin, the brain’s natural feel-good chemicals This helps create a positive feedback loop in our minds, where the more we practice gratitude, the better we feel.

Understanding Holiday Stress: A Genetic Perspective

Before diving into the power of gratitude, it’s essential to recognize that not all of us experience holiday stress in the same way Our Mood and Behavior genetic profiles play a significant role in how we process information, experience and remember events, and cope with stress. For example, genes like BDNF, DRD2, TPH2, and 5HTTLPR can influence neurotransmitters in our brains, affecting how we regulate our mood and respond to stressors

People with specific variants in these genes might be more prone to anxiety, emotional sensitivity, or even difficulty finding joy in situations that others might breeze through with ease Understanding that our response to stress has a genetic component can be empowering It allows us to approach self-care and stress management with more compassion, knowing that our reactions aren't just "all in our heads" – they're also in our DNA.

The Science of Gratitude and Stress Reduction

Gratitude is more than just saying "thank you." It’s a deeprooted feeling of appreciation that can profoundly affect how we experience life’s ups and downs When practiced regularly, gratitude has been shown to:

Reduce cortisol levels: Cortisol is often called the “stress hormone,” and its levels can spike during the holiday season Practicing gratitude has been linked to lower cortisol levels, which means a more relaxed and balanced emotional state

Enhance resilience: Gratitude shifts our focus from what we lack to what we have, fostering a sense of abundance and resilience that makes it easier to handle stressful situations

Actionable Gratitude Practices for Stress Relief

Practicing gratitude doesn’t have to be complicated Even small acts of gratitude can create significant shifts in our mindset and emotional well-being Here are a few ways to incorporate Vitamin G into your daily routine, especially during the holidays:

Gratitude Journaling: Start each morning or end each day by writing down three things you’re grateful for These can be simple things like a warm cup of tea, a good conversation with a friend, or even the crisp air of a winter morning The act of writing them down reinforces positive thinking and helps you focus on the good

Gratitude Walks: Take a walk and use the time to reflect on what you’re grateful for Being in nature or even walking around your neighborhood while focusing on positive thoughts can amplify feelings of well-being and reduce stress This is especially helpful during the holidays when our minds can become cluttered with todo lists and obligations

Mindful Gratitude Practice: Before bed, take a few minutes to reflect on the day’s events. Think of one or two moments that made you feel grateful Even if the day was difficult, try to find a silver lining, something that went right, or a lesson learned This practice can shift your perspective, allowing you to sleep more peacefully Express Gratitude to Others: Don’t keep your gratitude to yourself – share it with others Telling someone why you appreciate them, whether in person, through a message, or a handwritten note, strengthens your connections and boosts your mood During the holidays, expressing gratitude can also deepen your bonds with family and friends, easing tension and creating a more positive atmosphere

Gratitude Reminders: Set reminders on your phone or place sticky notes in your home to remind yourself to be grateful throughout the day A simple prompt like "What am I thankful for right now?" can help break the cycle of stress and redirect your mind toward positivity

The Connection Between Gratitude and Holiday Stress

The holiday season can be emotionally charged, often triggering memories and reactions that vary based on our genetic tendencies Some of us may find ourselves overwhelmed by sensory overload at family gatherings or fixated on negative thoughts due to our brain's wiring. This is where gratitude can play a pivotal role Gratitude helps us reframe our experiences, guiding us to focus on what’s going right rather than what’s going wrong. For those genetically predisposed to mood imbalances or heightened stress responses, this shift in focus can be incredibly beneficial. Instead of getting caught up in the chaos or the unmet expectations of the holidays, gratitude allows us to center ourselves and see the beauty in imperfection

Making Gratitude a Daily Habit

Like any powerful vitamin, consistency is key with Vitamin G Incorporating gratitude into your daily life, not just during the holiday season, creates a foundation of positivity that can buffer the impact of future stressors This practice is not about ignoring life's difficulties but about building resilience and finding moments of peace even in challenging times By acknowledging that our genetic makeup might make us more sensitive to stress and by adopting a daily gratitude practice, we give ourselves the gift of self-compassion and healing Gratitude is a way to transform the holiday season from a time of anxiety and overwhelm into one of reflection, connection, and joy.

As you navigate this holiday season, remember that your genetic profile may influence how you experience stress, but gratitude has the power to transform how you respond to it Embrace Vitamin G, and let it nourish your mind and spirit, guiding you to a holiday filled with more joy, love, and inner peace

References:

The BDNF val66met Polymorphism Affects ActivityDependent Secretion of BDNF and Human Memory and Hippocampal Function: Cell

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene | Science

Dopamine Receptor D2 Gene (DRD2) Polymorphisms, Job Stress, and Their Interaction on Sleep Dysfunction (mdpi com)

Effects of gratitude meditation on neural network functional connectivity and brain-heart coupling | Scientific Reports (nature com)

Practicing Gratitude for Better Health and Well-Being |

MISE EN PLACE:

THE SECRET MISE EN PLACE: THE SECRET

INGREDIENT FOR EFFICIENT, RELAXED INGREDIENT FOR EFFICIENT, RELAXED COOKING COOKING

By Lynn Angel, CFGP | The DNA Company

In this episode of The Secret Language of Cooking, I’ll discuss the most important secret of cooking Mise en place (pronounced “meez-awn-plahs”) is the technique that will transform your food preparation and cooking experience, regardless of the ingredients, style, ethnicity, or type of cooking

Imagine a frantic kitchen with pots and pans as you search for the right tool The staccato rhythm of your knife hacking a tomato, juices spraying everywhere Flour billows in a white cloud as you measure it straight into the mixing bowl The acrid smell of burning in the pan because you were searching for an ingredient in the back of the cupboard All while your heart races and your forehead glistens with stress-induced sweat It's a chaotic symphony of disorganization that leaves you feeling frazzled and frustrated, your appetite for cooking quickly souring Welcome to the chaos kitchen!

Mise en place has origins in French culinary traditions Professional chefs use this technique to create order in the kitchen for efficient, high-quality cooking. The concept of mise en place, a French term meaning "everything in its place," can significantly improve your cooking experience. In many cultures, food preparation is a communal activity Mise en place supports this by encouraging shared tasks among family or friends, turning cooking into a bonding experience In Mediterranean cultures, meal prep involves the entire family, fostering connection and tradition

Functional genomics has shown that our gene versions aren’t disease deterministic Changes in lifestyle, dietary choices, and minimizing exposure to environmental toxins can improve or downregulate gene expression Make mise en place your routine You’ll see the kitchen as a place where cooking meets your genetic influences Certain genes, like 5HTTLPR, TPH, COMT, and ADRA2B, affect mood and behavior, while FTO and MC4R influence appetite and snacking 5HTTLPR and TPH relate to serotonin and can impact mood and anxiety ADRA2B affects stress, and FTO and C4R manage appetite If these aren’t optimal, staying positive or resisting unhealthy foods can be difficult, leading to poor eating and emotional stress

Imagine coming home after a long day Instead of diving into a chaotic cooking session, you’ve set up your kitchen using mise en place You’ve prepped all your ingredients, arranged your utensils, and created a calm environment This organized approach streamlines cooking and lowers stress levels, crucial for those with genetic predispositions

By reducing anxiety and creating a serene atmosphere, you can enjoy cooking, making healthier choices feel accessible and enjoyable.

When you’re organized, it’s easier to prepare nutritious meals that cater to your dietary needs With less distraction and stress, you can focus on the flavors, textures, and nutritional value of your ingredients that will engage your senses rather than resorting to store-bought options that may not align with your health goals

This shift can enhance your relationship with food Cooking becomes a mindful practice, allowing you to appreciate what you eat and the effort you put into making it

Preparing meals with the mise en place technique can impact your mood and emotional well-being For those with suboptimal presentation of 5HTTLPR and TPH gene variations, creating a calming cooking environment can help mitigate anxiety and overwhelm Engaging in the sensory aspects of cooking like chopping vegetables or stirring a pot can be meditative, focusing your thoughts and fostering a positive emotional state This mindfulness can encourage healthier eating behaviors, as you’re more likely to choose nourishing ingredients when you’re in a good headspace.

Individuals with variations in the FTO and MC4R genes, which influence appetite and weight regulation, can benefit from the mise en place technique By preparing meals in advance and keeping everything organized, you’re less likely to reach for unhealthy snacks or processed foods Instead, you can focus on wholesome ingredients that satisfy your hunger and nourish your body Cooking becomes an intentional choice rather than a response to cravings or stress, reinforcing positive behaviors to counteract genetic predispositions

Incorporating the mise en place technique into your cooking routine nurtures a sense of accomplishment Seeing your arranged ingredients and the delicious meal you’ve created boosts your selfesteem and reinforces your ability to make healthy choices This positive reinforcement is beneficial for those struggling with emotional challenges related to their genetics Feeling empowered in the kitchen can lead to a more optimistic outlook, encouraging you to experiment with new recipes and ingredients that align with your health goals

Mise en place supports healthier eating and emotional well-being

It helps to organize your kitchen, making it easier to prepare and enjoy homemade meals, and engage all your senses This technique promotes mindfulness and counters negative gene influences. By adopting it, you can transform your cooking experience and relationship with food, impacting your mood and overall well-being. Give it a try!

Why Mise en Place Matters

Efficiency: Mise en place streamlines the process by preparing all ingredients before cooking. When everything is premeasured and arranged, you can focus on technique instead of searching for ingredients. This efficiency is crucial for those with limited time to prepare meals

Stress Reduction: Cooking can become overwhelming when managing multiple tasks Having everything ready and organized reduces anxiety, allowing for a more enjoyable experience This is important for health-conscious individuals trying new recipes or techniques

Improved Focus: When your ingredients are prepped and ready, you can concentrate fully on the cooking process This focus leads to better execution, ensuring meals turn out as intended

Better Time Management: Implementing mise en place in your kitchen routine allows efficient meal planning and execution This is vital when balancing work, family, and health commitments, fitting preparation into a busy schedule.

Enhances Creativity: A well-organized setup encourages improvisation and experimentation. You might discover new ingredient combinations that wouldn't have emerged in a rushed or chaotic cooking environment

Consequences of Skipping Mise en Place

Diving into cooking without mise en place can lead to challenges:

Increased Cooking Time: Searching for ingredients mid-recipe can slow down the process, making a quick meal take longer Mistakes and Waste: Without proper organization, it's easy to overlook or mismeasure ingredients This can lead to disappointing meals or the need to start over This is frustrating when you're mindful of waste and managing your food budget amidst soaring costs

Heightened Stress: An unorganized kitchen can quickly escalate stress levels, making cooking less enjoyable and discouraging you from preparing healthy meals

Mise en place is more than a culinary technique; it's a lifestyle choice supporting efficiency, organization, and health-conscious cooking Embracing this principle simplifies meal prep, reduces stress, and ensures you enjoy creating healthy, delicious food In our fast-paced world, adopting it transforms the kitchen into a calm, creative space.

A kitchen with mise en place exudes calm, focused efficiency Ingredients stand at attention in their prep bowls, like a culinary army awaiting your command Your knife glides through vegetables with smooth, practiced strokes, no wasted motion. The thwackthwack-thwack of dicing fills the air, a soothing rhythm that lulls you into a mindful presence. When it's time to cook, you move with the confidence and poise of a dancer, each step and addition carefully planned There's no last-minute panic, no thoughts racing ahead just the quiet, immersive flow of the process It's a meditative experience that nourishes both body and soul

Steps to achieve Mise

Steps to achieve Mise en place

Build a selection of small, medium, and large glass dishes in various sizes for chopped, diced, sliced, and measured ingredients

Ensure your chef’s knife is sharp and ready. Next episode, we’ll focus on kitchen knives: choosing, using, maintaining, and caring for them

Before cooking, read the recipe carefully First, read it once to understand the dish’s stages, then read it again to list all the equipment and ingredients

Clean your work surface and clear out any countertop clutter

Then, replace it with the items for the recipe

Accurate measurements are essential for consistent recipe results Use either metric or imperial, but stick to one set; never mix both

The most accurate way to measure dry ingredients is with a kitchen scale When following a recipe, use proper cook’s measuring spoons the dessert spoon isn’t an accurate tablespoon, nor is the teaspoon

All spoon levels should be level unless stated. For maximum accuracy with graduated measuring cups, spoon the ingredient loosely into the required cup, mound it slightly, then level the surface with a straight-bladed knife

Never measure ingredients over the mixing bowl We all remember when too much salt, flour, or seasoning spilled into the bowl

Preheat your oven for 15-20 minutes to reach the required temperature

Remember, higher temperatures mean longer preheating Most domestic ovens have hot spots, so rotate dishes from top to bottom or front to back during cooking for even results Adjust the cooking time for fan-assisted ovens

Invest in a good oven thermometer and use it to check your oven temperature regularly A faulty one often causes a failed dish, not you or the recipe.

I wish you Happy Holidays and stress-free cooking from my mise en place to yours!

YOUR HOME IS YOUR HEALTH

Mold is nothing to sneeze at

The Mayo Clinic reports that nearly all 37 million chronic sinusitis cases are mold-related. Additionally, the EPA found that 25% of asthma cases are tied to moldy and damp environments, impacting upwards of five million Americans annually

But mold's effects run deeper than respiratory issues.

A large Brown University study linked mold exposure to depression

Mold often triggers inflammation, a key factor in many chronic health conditions.

Emerging research suggests mold can cause or aggravate numerous diseases, especially autoimmune conditions

For immunocompromised individuals, mold can lead to potentially deadly fungal infections

My Wake-Up Call

When I was four and living in rural New Jersey, my asthma and allergies were so bad that I was falsely diagnosed with cystic fibrosis. What I was actually suffering from was asthma compounded by pneumonia, and allergies to nearly everything When my folks divorced and I moved out of our musty farmhouse, all my symptoms and allergies disappeared Back then it was simply chalked up to “spontaneous adolescent remission.”

It has become my life s mission to empower people with the tools and knowledge to make better decisions about the air they breathe, and the GOT MOLD? Test Kit is a big part of that.

Common Symptoms to Watch For

Mold is an equal opportunity pollutant. It affects some more than others, but nobody is 100% immune. Given enough time, it will bring the hardiest of us to our knees

Symptoms can be subtle and easily overlooked:

Sinus problems

Unexplained fatigue

Brain fog or memory problems

Persistent headaches or dizziness

Respiratory issues like coughing, sneezing and wheezing

Emotional shifts such as depression, anxiety, or irritability

Emergence or aggravation of autoimmune diseases

Hormonal imbalances

For women in midlife, these symptoms can overlap with natural hormonal changes, making mold a commonly overlooked factor

Taking Control: What You Can Do About Mold

We breathe about 20,000 times a day and spend nearly 90% of our time indoors, so the quality of the air we breathe is critical The good news is, unlike many environmental factors, indoor air quality is something you can control

Prevention Strategies

Moisture Control: Fix and clean up leaks promptly

Use dehumidifiers in damp areas

Maintenance: Check roofs, gutters, windows and siding to prevent water intrusion

Ventilate: Open windows regularly and use exhaust fans while bathing and cooking.

Keep It Clean: Household dust is often the first thing that mold colonizes upon

Monitor Humidity: Keep indoor levels between RH 40-60%

Materials: Choose moisture-resistant materials in moisture-prone areas like bathrooms and basements

Inspect Regularly: Check hidden areas closets, crawlspaces, attics, basements, under sinks, etc

A Holistic View

You can't exercise, meditate, or nourish your way out of a mold problem In fact, a mold problem will undermine all your well-intended efforts It’s that fundamental

What Can You Do Right Now?

1 Tune into your senses, and your environment Do you see something, smell something or feel something?

Do you notice signs of dampness or water damage? Look for stains, discolorations, condensation, water bugs, and of course, visible mold

Musty odors? The telltale smell is often the first clue, but it’s also a health hazard So if you catch a whiff, it’s time to take action

Do your symptoms improve when you leave the building?

2 If you say yes to any of the above questions:

If expense is not a factor, look into hiring a professional inspector

Avoid "free" inspections, which are often sales calls for mold remediators.

Consider the GOT MOLD? Test Kit for affordable, unbiased, professional-grade air testing

3. Act quickly: Mold grows fast, so early detection is key. The longer it goes, the more it grows, the more you’re exposed, and the more expensive it is to remove

Don't let poor indoor air quality be the weak link in your wellness chain. By taking charge of your home's air, you're making a powerful investment in your health and longevity. It's time to breathe easy

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Want more? Grab our free ebook, "How To Find Mold," filled with inspection checklists, FAQs, and more. [https://www.gotmold.com/ebook-landing-page/] And save 10% on all GOT MOLD? Kits using DNACO10 at checkout [ https://www gotmold com/shop]

10 THINGS YOU SHOULD KNOW BEFORE BUYING C60

By Ken Swartz, MS | C60 Purple Power

If you appreciate science, you’re probably aware that carbon is found in practically all organic and inorganic things It also plays a significant role in our daily lives Carbon is a component of our foods and is required for essential functions including metabolism and respiration

However, just when you thought you knew everything about the science of simple elements like carbon, there was a remarkable discovery of a powerful antioxidant called Carbon 60 (C60) In this article, we will look at this incredible carbon molecule, its benefits, and what you should know to guarantee you are buying C60 from a reputable company.

Carbon 60 Comes To Light

If you haven’t heard of Carbon 60, you’re certainly not alone The discovery of this complex carbon molecule in the mid1980s by a team of scientists took the science world by surprise and earned them the Nobel Prize

The C60 molecule has a unique structure consisting of 60 carbon atoms linked together This molecule resembles something that looks like a hollow soccer ball and is known as buckminsterfullerene, commonly referred to as the “buckyball” due to its shape, which was named after Buckminster Fuller Richard Buckminster Fuller, an architect and futurist, saw this shape before it was discovered and is credited with its association with the Carbon 60 molecule

Super Antioxidant — Carbon 60

Carbon 60 is considered to be a potent antioxidant and is sometimes referred to as a “free radical sponge ”1 Research has demonstrated that C60’s antioxidant capacity is several hundred times greater compared to standard antioxidants 1 What an amazing reason to explore more about how C60 may support your health.

Since oxidative stress can be harmful to the body, affecting all cells, C60 may help clean up the damaging free radicals by neutralizing them, thereby providing a cellular environment that supports the body to heal itself. You may easily imagine C60 working like a large broom, sweeping away the unwanted debris and remnants that cause your body to age

The importance of maintaining our cellular health is vital since every cell requires energy, and we want to ensure that oxidative stress is halted before any damage occurs As you may recall from your science classes in elementary school, cells get energy from a molecule known as adenosine triphosphate or, as you may remember it best, ATP The mitochondria are where the cell’s ATP is made and are the cell’s energy hub and C60 may help to support this function!

Research continues to unfold other benefits from C60 that may help to support optimal health such as supporting a balanced immune response It may also play a role in modulating allergyrelated conditions

Keep in mind that one of the most important things you should do before purchasing a Carbon 60 supplement is conduct your own research and learn more about the company that produces it Look for transparency in how they share ingredient information with their customers. Are they willing to provide you with third-party testing information, ingredient sourcing information, and any other product information you may require, such as a certificate of analysis? But there’s more, so let’s look at some other essential areas to look out for when you’re shopping around

Be Informed: 10 Things to Consider When Buying C60

Be aware of “special” names and marketing gimmicks It is important to note that there is only one C60 molecule provided by nature So despite what marketing campaigns companies use to try to sell you with overinflated promises of features and benefits, like saying their C60 is “supercharged” know that is not true!

Choose only 99 99%, pure, sublimated C60 What distinguishes some C60 manufacturing processes from others is the method to purify the C60 Not all companies use high-quality C60 purification processes In fact, the majority of corporations use the “vacuum oven-baked” process, which employs dangerous solvents like toluene, also known as methylbenzene – yikes!

This is key:

Look for sublimated C60 instead. Though it may be a bit more costly, sublimation produces a significantly cleaner result since it does not use solvents in the purifying process.

Only purchase 99 99% pure C60 because it is the highest grade C60 available

Read carefully and be aware of any company that touts that their C60 is 99 9%, or 99 95%, since that is regarded as a lower-grade C60 that has not been fully purified, meaning that there is a good chance that solvents are still in the C60

Choose organic products We know that your health is a top priority for you and your family and it is for us too. So, use 99 99% pure, sublimated C60 manufactured from organic oil rather than an oil containing glyphosate or other harmful compounds

Third-party verification and testing is a must This is simple If a company claims something – then they should be transparent and share that product information with you Look for third-party testing and ask to see the results of testing on your C60 product If they state that they cannot provide this, then you should consider purchasing from a credible source

Say NO to seed oils Not all oils are created equal! A quick rule of thumb is to look for oils such as organic extra virgin olive oil, organic coconut oil, and organic avocado oil, which may be associated with health benefits Avoid oils including sunflower, soy, vegetable, canola, sesame, and even blends of olive oil that are mixed with canola oil Also, be certain to steer clear of C60 oils that contain sunflower oil.

Look for FDA compliance and cGMP manufacturing standards This should be visible on the website and packaging If it’s not, this is a warning sign that you may not be purchasing from a reputable company.

Do your own research. We believe that you should always conduct your own research, trust your gut, and keep researching and asking questions

Ask your healthcare provider It is important to speak with your healthcare provider (HCP) about any questions you may have about C60 supplements and how they can benefit your health It is also critical to check with the company from which you wish to purchase C60 that it has credible scientifically supported information and references on their website that you can share with your HCP If you do not see any credible information or the company is unwilling to share any studies or reference materials with you, then you may want to look elsewhere

Trust Your Gut Your intuition and ability to research can arm you with the knowledge to be able to stay clear of fraudulent products. Tapping into how you feel and honoring those internal cues are instrumental in making d d i i R b h i d bt j t

Company information Check out the history of the company and the backgrounds of the members of the team and board. It’s a red flag to move on if you can’t find out who owns the company or who’s funding it

Stay Connected

If you are interested in starting a Carbon 60 supplement or any supplement, always check with your HCP. Feel free to share information on our page with your HCP and know that we proudly serve our customers with C60 products that are made with 99 99% pure, sublimated Carbon 60 that is never exposed to solvents

And a good to know all of C60 Power’s products are also third-party tested for purity, quality, concentration, and bioavailability If you have any product-related questions, we encourage you to give our awesome customer service team a call

These statements have not been evaluated by the US Food and Drug Administration These products are not intended to diagnose, treat, cure, mitigate, or prevent any disease Individual results may vary The information provided in this blog is for educational and informational purposes only and should not be construed as medical advice.

Ken Swartz, MS, is the founder and chairman of C60 Power, a health and wellness company committed to delivering the highest quality Carbon 60 products available Ken earned a Master of Science degree from the University of Colorado at Denver and a Bachelor of Science in Economics from Arizona State University

References

Liu Q, Cui Q, Li XJ, Jin L. The applications of buckminsterfullerene C60 and derivatives in orthopaedic research Connect Tissue Res 2014;55(2):71-79 doi:10.3109/03008207.2013.877894.

Liu Y, Jiao F, Qiu Y, et al Immunostimulatory properties and enhanced TNF- alpha mediated cellular immunity for tumor therapy by C60(OH)20 nanoparticles Nanotechnology 2009;20(41):415102 doi:10 1088/0957-4484/20/41/415102

Ryan JJ, Bateman HR, Stover A, et al Fullerene nanomaterials inhibit the allergic response J Immunol 2007;179(1):665-672 doi:10.4049/jimmunol.179.1.665.

CARBON 60: THE MIGHTY MOLECULE

about the Carbon 60 antioxidant Carbon 60 Overview

Before anything else, let’s dive into what C60 is and why it's the number one antioxidant you need to incorporate into your health and wellness tool kit this year Carbon 60 is a naturally occurring molecule that was discovered by scientists Robert Curl, Harold Kroto, and Richard Smalley in 1985 This monumental discovery is what earned them the Nobel Prize in Chemistry more than a decade later in 1996 as their study gave the scientific community one of the most effective antioxidants in nature.

It is worth mentioning here that C60 gets its name from the 60 carbon atoms that comprise this particular molecule These atoms form a hollow sphere that closely resembles a soccer ball.

Much of C60’s success as an antioxidant stems from the way its atoms are arranged This hollow molecular structure, also sometimes described as a cage, enables C60 to absorb and donate electrons from free radicals - thus effectively neutralizing them

What Does the C60 Antioxidant Do for the Body?

For those unfamiliar with the meaning of antioxidants, they are naturally occurring and serve to protect your cells and tissues from damage. Free radicals, on the other hand, are unstable molecules that wreak havoc on our bodies Excessive free radical buildup causes a process called oxidative stress This has been linked to adverse health effects that include premature aging and a long list of potentially life-threatening diseases Needless to say, antioxidants like C60 can aid our body in combating these conditions and promote general wellness

Why Should You Take C60?

C60’s application as a super antioxidant has major implications when it comes to one’s health and wellness By neutralizing toxic free radicals, C60 promotes a healthy inflammatory response and promotes a balanced immune response

Listed here are just some of the reasons why you should seriously consider taking C60

Boosts Energy Levels - One of the effects that people notice when they first start taking C60 antioxidants is the marked improvement in their energy levels This is because C60 promotes mitochondrial efficiency and increases adenosine triphosphate (ATP) production at a cellular level They may experience a stimulating effect and better energy levels throughout the day

Neural Protection - Studies have shown that nerves can suffer from oxidative stress and overstimulation. C60 helps protect nerves from overwork and stress

Supports Healthy Immune Response - C60 helps increase white blood cell production and supports the body’s ability to heal itself naturally Moreover, C60 helps optimize the body’s inflammatory response and exhibits antiinflammatory properties

Promotes a Youthful Appearance - It may come as a surprise, but C60 also has cosmetic benefits Specifically, C60 may lessen the appearance of fine lines and wrinkles. C60 may help protect the skin from oxidative damage caused by harmful ultraviolet (UV) rays Moreover, studies have shown that topical use of C60 may help support hair growth and wound healing.

Is it Safe to Take Carbon 60?

C60 has been found in scientific studies to be safe at even 10,000 times the standard dose. This is because C60 does not interfere with any of the body’s signaling molecules like other antioxidants do 7 C60 is beneficial and safe to use, provided you are consuming high-quality C60 from a trusted C60 manufacturer All C60 and all C60 products are not the same

Seek out C60 from a source that offers 99 99% pure, sublimated Carbon 60 Don’t settle for 99 9% or 99 95% C60, seek out the purest form of singly dissolved molecules of C60, and confirm that your C60 is human-grade and human-safe

The process of purifying and formulating C60 products can greatly affect their potency, quality, and effectiveness Look for C60 that has been purified through sublimation Sublimated C60 is produced without the use of solvents, whereas vacuumoven baked C60 contains solvents like toluene

Also pay close attention to the concentration of C60 per serving Some products may contain little to no C60 at all Any reputable C60 company will provide third-party testing to ensure you can see, with your own eyes, evidence that their products are safe and contain the C60 that they claim they do Moreover, do not be fooled by marketing gimmicks - fancy alternative names for C60, like “ESS60” or “Super-Charged C60 ” Companies that change the name of C60 are skilled marketers who are attempting to hide the toxic solvents they use in their C60

Next, it's critical to consume C60 in healthy oil This means avoiding C60 products made with oils that cause inflammation For instance, seed-based oils like sunflower oil are often cleverly marketed as health products, but they are considered allergenic and can be highly inflammatory for some people Companies will resort to using cheap, inflammatory oils to save a buck Do not fall for these tricks Do your research and educate yourself to ensure that you are only consuming oils that help the human body perform at its best That said, it is best to stick to non-allergenic, easy to digest oils like organic extra virgin olive oil, organic MCT coconut oil, and organic avocado oil

One thing has been made clear: when it is 99 99% pure, sublimated C60 in healthy organic oils, C60 is safe for human consumption Carbon 60 is significantly beneficial when it comes to ensuring your health and wellness Interestingly, if you have existing medical conditions, it is still safe to take C60. This is because the C60 antioxidant does not have any adverse effects on other medications, vitamins, or supplements

However, there are a couple of contraindications for C60 For instance, pregnant and breastfeeding women are dissuaded from using the antioxidant as there are no known human studies conducted to account for its effects on their condition The other contraindication is blood thinners. C60 may help to balance your blood density, so if you take C60, you will need to work with your healthcare provider to get your blood tested more frequently Taking all of this into account, it is completely safe to take C60 daily Adding C60 to your morning routine is an easy way to address oxidative stress and free radical buildup while also supporting your mitochondria and cellular health.

Conclusion

If you are looking for an effective way to protect your health, then Carbon 60 is certainly worth looking into. C60’s unparalleled ability to combat free radicals and oxidative stress, not to mention the additional health benefits you may notice, makes Carbon 60 a worthwhile investment in your wellbeing

References

1 Ali SS, Hardt JI, Quick KL, et al A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties Free Radic Biol Med 2004;37(8):11911202 doi:10 1016/j freeradbiomed 2004 07 002 https://pubmed.ncbi.nlm.nih.gov/15451059/.

Liu Q, Cui Q, Li XJ, Jin L The applications of buckminsterfullerene C60 and derivatives in orthopaedic research. Connect Tissue Res. 2014;55(2):71-79. doi:10 3109/03008207 2013 877894 https://pubmed ncbi nlm nih gov/24409811/

2 Dugan LL, Gabrielsen JK, Yu SP, Lin TS, Choi DW Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons Neurobiol Dis 1996;3(2):129-135 doi:10 1006/nbdi 1996 0013 https://pubmed.ncbi.nlm.nih.gov/9173920/.

https://pubmed ncbi nlm nih gov/19755733/

4 Ryan JJ, Bateman HR, Stover A, et al. Fullerene nanomaterials inhibit the allergic response J Immunol 2007;179(1):665-672 doi:10 4049/jimmunol 179 1 665 https://www.jimmunol.org/content/179/1/665.short.

5. Fullerene is effective against wrinkles Journal of the American Academy of Dermatology 2010;62(3 Suppl 1):AB22. https://www.jaad.org/article/S01909622(09)01600-4/fulltext

6 Merry TL, Ristow M Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J Physiol 2016;594(18):5135-5147 doi:10 1113/JP270654 https://www ncbi nlm nih gov/pmc/articles/PMC5023714/

7 What Is C60? WhatisC60 org https://whatisc60 org/ 8 C60 Health Benefits Backed by Scientific Research C60 Shop, Inc 2024 https://shopc60 com/pages/research

Ken Swartz is a biogeochemist and Chairman at C60 Power (shopc60 com), a health and wellness company committed to delivering the highest quality Carbon 60 products available Ken earned a Master of Science degree from the University of Colorado at Denver and a Bachelor of Science in Economics from Arizona State University

A WHOLE NEW BEGINNING AT MENOPAUSE

By Maryon Stewart, BEM | Femmar

Imagine feeling full of energy and like your former sexy self, loving your reflection in the mirror Well, I’m here to tell you it’s possible to get back to feeling even better than you can remember. Instead of getting caught feeling like menopause is the beginning of the end, you get to realize that it can be a whole new beginning As well as the negative aspects of midlife that we so often focus upon, there are many positives that this life stage brings despite the fact there are massive knowledge gaps

According to a recent survey, two-thirds of women admit to being completely unprepared for menopause They have negative views on their well-being prospects once they hit perimenopause, and two-thirds report they feel scared stiff that it’s the beginning of the end of life as they knew it What they fail to understand, because no one is actually telling them, is that, with a little sound knowledge, menopause can be the beginning of a whole new positive and exiting chapter in life

Most women are so consumed by hype of the downside of menopause, they forget to look for the gifts that Mother Nature brings at midlife.

First, and most obviously, women no longer have to deal with their periods each month Once you learn how to correct nutritional deficiencies, get your nutrients into an optimum range (as research shows that billions of women have low levels of important nutrients), and get hormones back into balance, every day of the month can be a level playing field with no premenstrual mood swings

An added bonus of making the dietary and lifestyle changes shown by researchers to help us control menopause symptoms is that we are also “future proofing” our health. Learning to meet our needs at midlife helps prevent serious diseases that we are at greater risk for once our ovaries cease functioning These include the silent bone thinning disease osteoporosis, which in itself can be crippling; heart disease, including high cholesterol and high blood pressure; and the brain wiping condition dementia. Although it takes a few months to reap the benefits of dietary and lifestyle changes, it’s well worth the wait Over 90% of women who go through my program report feeling better than they can remember Their thermostat works normally instead of having overwhelming thermal surges, they have peaceful sleep for the first time in living memory, and clarity of mind replaces their scary brain fog. They experience renewed energy instead of feeling tired all the time, swap apathy for enthusiasm, and even get playful in the bedroom instead of feeling switched off from the waist down Plus, their skin and hair once again glow and people comment about how much younger they look

Once women have reclaimed their well-being at midlife, they have so many choices as their wiser selves Some continue to confidently climb the corporate ladder, others decide to retrain, gaining new skills that offer them new opportunities, or make the most of their leisure time. With their children often having flown the nest, they have more time to focus on adventures and rekindling loving relationships with themselves as well as their partner

Maryon Stewart is the author of Manage Your Menopause Naturally and 27 other books. A worldrenowned healthcare expert, she has helped tens of thousands of women around the world overcome menopause symptoms without using drugs or hormones She is the host of the new PBS TV series Maryon Stewart’s Menopause Makeover Watch the show and join her community at https://naturalmenopause.tv. Details of her program can be found at https://femmar com

DNA University, known as DNA-U, is a premier educational platform, focused on genetic expression and understanding, designed for health and wellness professionals and business leaders who are eager to excel in the rapidly growing field of Precision Wellness. The DNA-U delivers bleeding-edge material and science courses in genetics, epigenetics, metagenetic studies, and functional medicine. DNA-U equips their students with the knowledge and skills needed to stay ahead in an evolving industry

By focusing on the integration of genetic insights into clinical practice, DNA-U empowers its students to transform patient care, enhance business growth, and lead the future of Precision Wellness Whether you are looking to elevate your practice, improve client outcomes, or explore the latest advancements in science and healthcare, DNA-U provides the resources and support to help you achieve your professional goals

An

exclusive interview with Kashif Khan, Co-founder of The DNA Company by Tracy Wood, CEO of The DNA Company

TW: Hey Kash! Thanks for stopping by to share some of your story with our readers in the DNA Talks Digest.

KKO: No problem I’m excited to do it!

TW: You know, I want people to kind of understand how The DNA Company emerged, right, and how we became a leader in the genetic interpretation and biohacking space and what specifically drove you into making the decision that DNA biohacking was what you wanted to do I mean, you were a very successful businessman. I want to just kind of paint that picture of what that passion was that made you feel compelled to go into this space

KKO: So, there were a couple things First, I was sick

TW: Okay, so tell me a little bit about that, because I don't know a lot about that

KKO: So, a few years prior to The DNA Company, I met Bryce [Dr Bryce Wylde, Co-Founder] through the business I used to run, which was a marketing company I helped technology start-ups grow, right, everything that they didn't know that they needed to know, I provided

And one of the start-ups was a health tech company that took blood work and helped people better understand their own health. I had never been sick, never needed a doctor I didn't know what the health care system was, right, and while building that company with Bryce, I actually got sick I got eczema all over my face I got psoriasis all over my body I got horrible gut issues, and I didn’t want to leave home because I couldn’t predict what it was going to be like I had depression and didn’t want to get out of bed Finally, what drove me to the doctor was I got migraines I would vomit and the pain was brutal, all I could do was sleep My instinct was to go to the doctor, and I had a friend who ran the hospital in Toronto, so he got me MRIs and all this stuff very quickly and the answer was “you're fine ” I said, “No, I’m not fine ” Eventually I had multiple different doctors giving me multiple different pills

TW: How long ago was this?

KKO: This was like 2015-16 around there So, I started to question - just straight logic, right? What did I do? I've never been sick, but now, I have five chronic conditions all at the same time, actually six, including after reflux And that was the first time that I realized that fixing sick people is not what doctors do I actually had no clue I was naive, right?

And then when I learned that I started to dig So, I went back to Bryce and said, “What do you do? Please explain it to me ” And then he started introducing me to functional medicine and naturopathy and homeopathy and I started diving deep I started using traditional Chinese medicine and homeopathy And then I remembered when I was young, my dad used to take me to a traditional Chinese medicine healer and a naturopath It was something that he really loved, but he didn't have money to pay for, right? He just knew I was learning and I completely forgot because I got busy working And it reminded me of all this stuff my dad taught me And so, then the big AHA moment was, I did a genetic test.

TW: What test did you do?

KKO: It was through Dr Mansoor Mohammed So, at that time, I was already halfway there using what I learned from Bryce I was much better because I started to learn all this stuff and apply it I got rid of my reflux, my eczema, etc And then I met with Mansoor and Bryce, learned about a few broken genes and started to hyperprioritize working on that, especially my gut, which I had no clue was involved in any of this And that was the first time that I realized that systems are interconnected The problem doesn’t always come from where the symptom arises There are things deeper, right? I started to fix my gut and learned that functional medicine was a much better source of healing for me. And then came the bigger AHA moments I got better at the root I actually started to fund research Bryce and Mansoor literally sat at my dining room table for months, building this algorithm because I said there's so much more here than you guys think there is It should be easy and accessible and Mansoor as a scientist, you know, just like any other scientist didn't believe that was true Right, you need a PhD to understand the reports and results I knew we could do it I said, “Let me make it easy, right?” And they sat at my table teaching me and I started to understand it. I could see the patterns and see how it could be easy and recognizable and built into algorithms that were repeatable and trainable, right? So, my job then and there was to understand and make it relatable for others who didn’t study genetics We had no idea what we were even doing other than I saw the world needed this root level of understanding I didn't know what to deliver, but I knew we were onto something that had to make it to the public domain I actually raised the money and started building a lab I was funding the other side of the research, which was supplements, and how to actually fix these problems

And while they were building the lab I got sick again because these guys were building the lab using toxic epoxy glues, which I didn't realize I had a problem with So, once again I dug into my DNA and found out that there’s answers there But this time, I figured it out myself for the first time, right? And that was the moment where I realized I can build a tool that I can take out to the world That's when I decided to raise money and fund the science, and The DNA Company was formed

TW: Okay, so when you said you fixed your gut and you fixed your eczema, what did you do? What supplements did you use? What did you physically do that took you from where you were to where you said you were cured of these things?

KKO: What did I do? So, there were a few things Everything I told you happened over period of like one and a half years, right? So, I built a custom cocktail of supplements that supported my broken biology What I realized is once you discover in your DNA that there's a job that your body doesn't do well, you have two choices You remove the thing that is the threat, or you add something to support your biology so it can handle the threat. And I did a little bit of both, which was I understood how I was burdening myself with stress I understood that I was, you know, in control of my stress, and I got to repair using what I understood with certain nutrients Like for example, glutathione, I realized that I need two very specific forms of vitamin B. I realized that my hormones were imbalanced I realized that I needed to train differently than I was training My training was actually making me sick And I actually started exercising less and feeling better, right? So it was a combination of those two things, kind of a blueprint for me of here’s everything that’s a threat and get it out of my life I understood, here’s everything that my body doesn’t do right Here is how I become the best version of myself That’s kind of what I did

TW: That’s amazing, Kash! So how long did it take you once you kind of started to figure out genetically where the challenge was? Now you didn't have a DNA 360 test, you had just your gene information. I mean, what kind of information did you glean from that test that you did with Mansoor?

KKO: It was not quite the full DNA 360, but it was about 70% of the way there

TW: Interesting

KKO: Yeah, it was most of it And then the DNA 360 was developed, I would say in 2020, I think, around there And most of the holes and gaps were filled. Then there were a few more things we knew we needed to know, so those got added And I don't think that I'll ever stop Like you're now adding more, right?

TW: Exactly, genetics and science evolve. We are always learning and validating

KKO: What I also learned, the first step for me when I first did a genetic test, it also sucked These tests pull a bunch of useless data, right? I was like, this is useless information and it wasn’t until I saw the functional side where it started to look at a lot less raw data, but in a functional view, we dived deeper within that less useless information Only then was I actually able to do something with it So that was where the 360 came from, which was sort of cherry-picking the information that people actually need, not chasing big data because I'm trying to sell data to big pharma on the back end Like 23 and Me, which is why they failed because they don't actually help people, they help big pharma, right?

TW: Right So, their goal essentially was to chase all of that shotgun blast data and create drugs from that data, but it still comes back to the same challenge, right? If you don't have something that was specifically created for you based on your genetics, that drug is really a blanket on a bullet wound, right?

KKO: Yep, first of all, their belief was wrong, that genes equal disease So they were looking for all these needles in all these haystacks, but that’s not how the body works The body works with combinations of bad biology plus your habits, and because they ignored the epigenetics, they didn’t, you know, deal with people, they only dealt with genes, and they didn’t solve any problems And, if you’re a drug company, that’s what you want to do, right? You want to create the magic bullet for the problem, but there is no magic bullet, you have to understand everything about environment, lifestyle, etc So, they have to integrate all of that into an integrative view And they didn’t

TW: Potentially, the failure to do that by their CEO [Anne Wojcicki], it is now evident, right? They almost got delisted [from the stock market] just a week or so ago and [their stock has] gone back up to four or five dollars. I haven't checked it this morning, but while they've gone back up, they still have the same core problem She’s still looking to be a drug manufacturer or even creator, right? She’s still looking to do that rather than finding a wellness and holistic wellness solution for people who are fundamentally sick.

KKO: So, a big part of 23 and Me’s origin story is she chose to take $300 million from Glaxo Where is that money going to go? It’s never going to go back to research for genes and gene expression to solve chronic illnesses, right? So, we chose to stay private. I actually sat down in a meeting with a venture capital firm here in Toronto that gave me paperwork agreeing to fund us, right? But when I received that paperwork, I had to make a choice Do I sell our soul? Or do I do what I think is possible and actually change health care? And I didn’t sell out And so, instead I grinded and broke my body raising money by knocking on doors, right? That’s why we’re on the path we are, not like her tied down to Glaxo If they gave us $300 million, who would our vision and mission belong to?

TW: Exactly She’s stuck

KKO: Exactly

TW: Kash, you know, a lot has happened since the company came out with DNA360 We now have five tests that we do They are for a multitude of things not the least of which, of course, is cancer. And we know 70% of all cancers diagnosed in America are never tested for until they are discovered whether it be mass, pain, or symptomology Since I became CEO, we’ve decided to continue on the path of more testing, better testing, always developing another view at another part of the human body. This is all part of your vision.

KKO: Right

TW: What do you think will be your legacy at The DNA Company? Maybe it’s how you took us out of no one knowing who we were to making us a globally recognized brand?

KKO: Yeah, I think it’s that the brand exists so people have a place to go and that was step one to actually help people and solve their problems Now it’s the global community and beyond to the health and wellness industry itself and we’re seeing that tipping point now where the clinical community is now coming and learning from us to better facilitate their own patients with extreme precision Many of these doctors and clinicians are saying, I’m sick of what I do. I’m jaded I don’t want to guess to help people anymore And can I please learn? Right? I think it’s to the point where they have the comfort in knowing that we have helped so many people that they don’t need to be living in uncertainty, which is what they’re wired for They’re indoctrinated to believe that unless it came from a government source, it’s not true Right? That’s why I think the next step is consumers made a choice Now the industry is going to make a choice And my job is to keep advocating, keep making sure that people know about it. Now with the changing government and Robert Kennedy talking about changing the health care system, there’s momentum there, right? And a lot of the stuff that we’ve been saying and doing when people said that we’re woo woo and conspiracy theorists is now exactly what these guys are talking about.

TW: Well, yeah, but let’s get what Robert Kennedy says all through the election, he was saying how he was going to come down on and maybe even get rid of the vaccine And then the day after the election, he says, oh, I’m not touching anybody's vaccines From what I am reading, he has he done the same thing as everybody else. Has he said whatever it took to get into a position of power. These politicians turn around and do kind of like what we say these other DNA companies did, take the drug money, take the insurance money, and now they’re owned by them. So, the jury is definitely out for me, so far.

KKO: Yeah, well, that’s why we can’t stop what we’re doing because we can’t rely on these guys where we don’t have a government, we have an oligarchy, we have a bunch of companies that push buttons, right? So we can’t stop

TW: Right, yeah, I agree, Kash And I think one of the things that, to speak to your point earlier, it’s retraining these people

KKO: These doctors have absolute fatigue

TW: These practitioners are so sick and tired of their patients being sick and tired that creating The DNA University content like we did and making this now an accredited course, that's accepted in the United States and respected in the United States by the American Association of Natural Wellness Practitioners, I think that that’s a huge step forward, don’t you?

KKO: Yeah, I think that it’s what’s needed because they want it So, post COVID all these clinicians learned how broken their system was and how close everybody is to poor health, right? Most people didn't know how little it took to push them to the other side of health and so clinicians realized that they don’t know genetics, root cause, nor were they taught it at any depth in many cases They don’t have control over the functional side and so they want the training, they want the knowledge, they want the tools, right? They don’t even have the tool kit, that’s another big challenge So that tool kit is going to come from outside of their world, which is what The DNA Company is doing

TW: Yeah, you know, during the convention this past month, we were in Miami together And I talked to a lot of doctors after your presentation. I talked to quite a few of them, and the same recurring conversation: We [doctors] go through medical school, we’re taught to memorize everything from the 40s and the 50s and the 60s, very seldom do we get to be a part of the evolution of medicine, the evolution of this change in medicine And, you know, I think that that’s what we’re seeing.

So many companies for the longest time didn’t even speak to the genetics of a patient. When I was younger, we heard, “Well, diabetes, cancer, heart attacks, runs in the family ” Well, if they knew that back in the 70s, why in the hell didn’t somebody sit down like you and say, I want to look at this biology, I want to look at these gene sets. And I want to figure out how I can use environment and supplementation and lifestyle to alter these things, to alter this symptomology

KKO: There's a very simple reason why, because researchers research, whoever's funding the research, right? So, if there’s no funding, the researchers aren't business people. They don’t have the cojones, let’s say, to go out there and do it themselves We had to self-fund this, literally it was me and our private money investors paying out pocket for guys sitting at my dining room table, right? Researchers don’t want to do that unless they know they can get, you know $67 per pill and a recommendation of 18 months on a course of medication

TW: I appreciate you sharing all this information with me. I want to close it out with what do you see for the next five years? What do you see in our space? What do you see in our education contribution? What do you see The DNA Company doing for its community over the next five years?

KKO: I see a couple things. I see that The DNA Company has the understanding of root cause, meaning there’s plenty of guys out there building widgets and tools, but they still are somewhat in the dark in trial and erroring things, right? The DNA Company offers to academia and innovation is precision Name the disease and our reverse engineer functional training will tell you why it happens So, if we know that, now we can start building the right tools, right? As opposed to pills and even the biohacking world, a little bit of the one-size-fits-all, right? Right I see it going from testing to education to eventually integration, like helping the industry do a better job And that’s where it ends up going to a lot more people because now the tools get better The tools actually solve the right problem That’s what I see coming

TW: Love it, love it. And of course we’ve got our app coming, right? So, people will be able to take their gene data from 23 and Me, drop it into the app, and see what’s missing so that they can still look at solutions and a plan for longevity and optimal health. So that’s going to be fun and exciting. All right, Kash, well, I appreciate you spending this time with me Thank you for sharing your insights, and we’ll get this into the magazine for the end of the year

UNLOCK YOUR HEALTH POTENTIAL: THE DNA WAY

“Your DNA can empower to make life choices that lead to a happier, healthier life The DNA Way is a preventive guide to various health issues and their link to an individual’s DNA.”

KASHIF KHAN

Author and Co-Founder

“The

knowledge you need for your own longevity and vitality. ”

STEVEN R. GUNDRY, M.D.

“The ultimate life hack to take control of your health, performance and longevity”

Our Provider Partnership Program sets practitioners and clinicians up with the education, tools, and VIP level support they need to successfully integrate functional genomics and our revolutionary suite of testing into their practice With a patient’s genetic blueprint and access to additional functional testing, you can offer a personalized precision approach to health and longevity for those you serve

In this program, we start with The DNA University (DNA-U) This fully accredited course, centered around the newly recognized area of functional genomics, helps providers uncover the individual blueprint of each treated patient

Upon successful completion of the course, you are assigned the Certified Functional Genomics Practitioner (CFGP) designation after your name for professional use. CFGP is the new and recognized standard for functional genomics. This sought after designation demonstrates both prestige and expertise in your clinical area of practice This commitment to your own continuing education proudly displays dedication to your field, and more importantly, to your clientele This can boost your reputation and exposure to new clients

At The DNA University, our founders, CSO, and other industry thought leaders cover the functional interpretation of genetics and genomics We know that genomics and its study is the new frontier and likely how all medicine will be practiced one day Because of that, and the constant need for science to be up to the moment accurate, we provide a lifetime access to The DNA University, and to our published papers and materials This gives you exclusive access to new training modules as they become available

To help you support your practice, and to assist in the expansion of your revenue, we create, develop, and update the libraries keeping you at the bleeding edge of functional genomics Achieving certification gives you confidence that your knowledge and abilities meet recognized standards With The DNA Company as your chosen partner, all DNA-U students have private access to monthly webinars, hosted by our faculty. A dedicated student inbox is monitored to ensure any questions you have throughout the process are answered by qualified medical professionals and scientists In addition to the phenomenal connective tissue to our community and faculty, we design and provide product brochures and information decks that are available in the student resources area so you can present professional materials for patients visiting your clinic or for use on social media or in email marketing campaigns Not only does DNA-U set you up for success, but it also provides continued access to grow your business and build your brand

HOW CAN YOU GET STARTED?

Links to get started on your path and enroll today: The DNA-U Certification & Mastery Bundle (thednacompany com) Only DNA-U graduates are invited to create a Wholesale Provider Account upon successful course completion This account is only available for medical and wellness professionals that are accredited through DNA-U or have a recognized designation or medical license qualifying them to provide our testing and lifestyle recommendations to patients

STEP 1: REGISTER FOR YOUR WHOLESALE PROVIDER ACCOUNT HERE

Answer YES or NO to the NPI # and then click "Get Started" at the bottom right and complete all forms We will send you a confirmation email of your registration

STEP 2: LOGIN TO MANAGE PATIENTS, ORDER TEST KITS, AND VIEW RESULTS.

Go to: https://clients thednacompany com/login aspx (your wholesale portal) and sign in with the username and password you created If you have set up multiple practitioners on the account, the PRACTICE access will be the primary access and the PHYSICIAN access will be used by each practitioner so that patient records can be separated as needed Go to "Orders" on the left side menu and “Submit New Order” to fill out the order form

You will receive a New Provider Welcome Email from our clinic support team once your account is approved. This email provides additional information about the products and services available through the account along with all pricing sheets You will have a dedicated support team who are available to answer questions, assist you with navigating your account, processing orders, or accessing testing results in the system.

Through your account, you will order testing and supplements at wholesale prices The account is intended to work best when you charge your patient the retail price and take payment directly from them, either through your online store or in person Once you’ve collected payment, you can generate a new order You can have the order shipped to your clinic or directly to your patient. You pay The DNA Company the wholesale price, giving you a margin on each product as profit Many providers also choose to stock kits if they are running a brick-and-mortar clinic or including testing in their packages and programs

MORE INFORMATION ABOUT THE WHOLESALE PROVIDER ACCOUNT:

WHOLESALE, SRP & SHIPPING INFORMATION

Link to view current tests and pricing: DNAco Products -Clinicians - August 2024.pdf Link to view current Black Label Supplements and pricing: Black Label Supplements Each test and supplement has a wholesale price and a suggested retail price, giving you a built-in profit margin

For example: Wholesale DNA kits are $349 USD, suggested retail is $499 USD, shipping within the United States is $22 50 USD per kit, which includes a return postage paid envelope to the lab.

For all addresses outside of the United States, you will see the shipping amount when an item is added to the cart. For international orders, one-way shipping is charged upfront, your patient is responsible for return postage back to the US-based lab along with any applicable duties and taxes We always recommend using a carrier that provides tracking on the return so that your patient has peace of mind knowing it is received by the lab

KIT REGISTRATION PAYMENTS

Each test will include a clear set of instructions so the patient can perform the test at home and register the kit ID to create an account. Please tell your patient that they must register their kit barcode and create an account prior to returning their sample to the lab A QR code is located inside the kit box and instruction card; it contains important information on the test ordered If you would like an electronic version of any of the test kit instruction manuals, we can provide it to you

All orders are paid in full at the time the order is placed and are non-refundable once shipping has taken place You can visit our website and review all our company policies.

LAB PROCESSING

We have multiple lab partners within the United States, depending on the test ordered, processing times vary Our lab address is printed on the instruction card enclosed in the kit and we have a dedicated clinic support team if you have any questions You can also monitor the status of the DNA 360 results from your portal

Now that your Provider Application and Training is complete, you are equipped to provide the highest level of patient care, our team is here to support you, and we wish you all the best in your future success!

The DNA Breast 360 is a groundbreaking, non-invasive breast cancer screening test that analyzes specific proteins in tears to detect early signs of breast cancer. Designed to complement traditional methods like mammography, this innovative test provides an additional layer of insight into breast health, particularly benefiting younger women under 50 and those in rural or underserved areas who may face barriers to regular screening.

HOLIDAY GIFT GUIDE

Welcome to The DNA Company Gift Guide! We’re thrilled to present an exclusive selection of products from our valued partners who are as passionate about health and longevity as we are

This carefully curated guide is here to help you discover incredible products dedicated to enhancing wellness, making it easier to find meaningful gifts for loved ones or start your own health journey in 2025

With fantastic Black Friday/Cyber Monday and holiday offers, you’ll get early access to the best in wellness and longevity solutions an unbeatable way to set yourself and those you care about on the path to a vibrant new year!

RADICAL ROOTS

BEAM MINERALS

Gift Vitality This Season with BEAM MineralsLasting Energy, Clarity, and Wellness.

This holiday season, give the gift of lasting energy, enhanced focus, and overall wellness with the BEAM Minerals Advanced Set! Designed as a powerful duo, this set includes bioavailable liquid minerals that deliver essential nutrients directly to the cells, supporting balanced energy levels, mental clarity, and optimal health BEAM Minerals are formulated for quick absorption, so the body can efficiently utilize these vital nutrients without the strain of digestion It’s the perfect gift to keep your loved ones feeling vibrant, grounded, and ready to take on each day with renewed vitality and resilience. Make wellness the most meaningful gift you share this season!

USE CODE DNACO FOR 20% OFF AT BEAMMINERALS.COM AND MAKE HOLIDAY WELLNESS A BREEZE!

Rediscover Calm & Deep Sleep Naturally with Rest and Relax by Radical Roots

Introducing Rest and Relax by Radical Roots: a blend of full-spectrum hemp and classical Chinese herbs designed to help you unwind. Rooted in Suan Zao Ren Tang, this formula combines ancient herbal wisdom with modern insights into hemp's calming effects Key ingredients like Suan Zao Ren, Ye Jiao Teng, and He Huan Pi nourish the heart, blood, and yin, while CBD eases anxiety and balances your nervous system Quiet your racing thoughts, release tension, and let your body relax naturally Rest and Relax helps you reclaim restful sleep and find the tranquility you deserve

USE CODE DNACO35 FOR THE 35% OFF THE REST & RELAX TINCTURE UNTIL THE NEW YEAR

PLUCK

Pluck transforms any meal into a nutrient-rich dish with its blend of grass-fed organ meats.

Pluck is the simplest way to add nutrient-dense, flavor-packed seasoning to any dish Crafted with freeze-dried, grass-fed organ meats and organic spices, Pluck enhances both taste and nutrition, making healthy eating effortless

BLACK FRIDAY -

CODE: BF25 = 25% OFF + FREE SHIPPING

DATES: NOVEMBER 25TH TO DECEMBER 1ST

CYBER MONDAY -

NO CODE NEEDED: BUY 2 GET 1 FREE DATES: DECEMBER 2ND TO DECEMBER 3RD

BRAINTAP

Enhance Your Mind, Transform Your Life: BrainTap for Effortless Focus, Sleep & Stress Relief

Unlock the power of your mind with BrainTap, the revolutionary brain fitness company that offers an all-in-one solution for better sleep, less stress, and increased focus Our cutting-edge app and accompanying headset deliver leading-edge brainwave training technology and guided visualization techniques to optimize your brain's performance, resulting in an average 38 5% improvement on the stress index scale after just one session The best part? It's effortless! Simply put on the headset, kick back, close your eyes, and listen to one of over 2,000 audio visualizations on BrainTap’s mobile app, then enjoy the results If you are looking to enhance your brain fitness, rekindle your creativity, reach peak performance, or triumph on the field and in life, BrainTap is for you In today's fast-paced and stressful world, BrainTap is on a mission to better a billion brains, empowering people just like you to take control of their mental and emotional well-being in just 20 minutes a day

POWER PLATE

OFFER: BLACK FRIDAY/CYBER MONDAY -

$697 POWER BUNDLE REGULARLY PRICED AT $907

$597 HEADSET REGULARLY PRIECD AT $797

$180 1 YEAR OF ACCESS SUBSCRIPTION REGULARLY PRICED AT $260

SALE DATES WILL RUN - NOVEMBER 29-30 FOR BLACK FRIDAY AND DECEMBER 2-3 FOR CYBER MONDAY THE ABOVE PRICING WILL ONLY BE VALID ON THOSE DATES

The Smart Way to Keep Moving and Aging Well

As we age, maintaining physical health becomes increasingly important Power Plate offers a proactive way to invest in your long-term well-being Utilizing whole-body vibration technology, it sends gentle vibrations throughout your body, triggering natural responses that enhance muscle strength, bone density, circulation, balance, and flexibility This technology acts like a mini-workout for your body, helping you stay strong and active

Trusted by celebrities like Mark Wahlberg and Serena Williams and used by professional sports teams across the NBA, NFL, and MLB, Power Plate is backed by over 40 scientific studies demonstrating its effectiveness in promoting health and longevity

ENJOY 25% OFF SITEWIDE PLUS RECEIVE A FREE PULSE MASSAGE GUN WITH YOUR PURCHASE UNTIL DECEMBER 2ND

VIVA RAYS

VivaRays is dedicated to restoring balance to your life through the science of light exposure In a world filled with unbalanced artificial lighting, VivaRays provides all-day circadian glasses designed to reset your body’s natural rhythms, harmonize hormone regulation, and support overall wellbeing Guided by a deep respect for nature and backed by research, VivaRays empowers individuals to reconnect with the natural cycles that enhance health and vitality.

20% OFF CIRCADIAN GLASSES: OUR CIRCADIAN GLASSES HELP YOU REALIGN YOUR LIGHT EXPOSURE, BRINGING YOUR HORMONES, ENERGY, AND SLEEP INTO BALANCE

FREE EARPLUGS: ENJOY A PEACEFUL NIGHT’S SLEEP FREE FROM BACKGROUND NOISE AND DISRUPTIONS. THESE HIGH-QUALITY EARPLUGS, VALUED AT $27, ARE DESIGNED TO PROMOTE DEEP, UNDISTURBED REST

FREE ACCESS TO THE WINTER COURSE: WITH THIS $297 COURSE, LEARN HOW TO EMBRACE WINTER AS A SEASON OF REST AND RENEWAL. GAIN INSIGHTS ON WORKING WITH NATURAL CYCLES TO SUPPORT YOUR WELLNESS.

MARA LABS

3RD ROCK ESSENTIALS

3rd Rock Essentials is a Virginia Beach-based team dedicated to bringing you the safest, toxin-free personal care products Founded in 2003 by a renowned chemist and natural products activist, 3rd Rock has consistently grown and continues to formulate innovative products using the science of nature Their patented chelated silver and chelated zinc oxide formulations are not found in ANY other products.

Common ingredients found in many personal products you use every day can be harmful These include endocrine disruptors, parabens and petroleum 3rd Rock products completely avoid these toxins and use only natural, food-grade ingredients to provide the most effective results

Since your best health is their goal, the team at 3rd Rock Essentials have now included chelated D3K2 and chelated zinc oxide supplements as an easy to take liquid that provides optimum absorption and function All 3rd Rock products are manufactured and packaged in the USA and are never tested on animals Pure, Potent, and Proven Supplements for a Healthier You

33% OFF UNTIL DEC 31, 2024 (INCLUDES SINGLE AND 3-PACK) COUPON CODE NEEDED AFTER DEC. 4 TO CONTINUE THE BFCM SALE: BESTHEALTH

BrocElite® Plus: Defend Your Cells with Stabilized Sulforaphane

Every day, we're exposed to environmental toxins like glyphosate a pervasive chemical found in our air, water, and food (and the main active ingredient in the herbicide Roundup) BrocElite® Plus by Mara Labs provides a powerful defense with stabilized sulforaphane, the only known molecule that can protect your cells from glyphosate's harmful effects Sulforaphane activates the Nrf2 pathway, supporting your body's natural detoxification processes and promoting cellular health

Backed by over 2,000 peer-reviewed studies, sulforaphane has been shown to aid in detoxification, reduce inflammation, boost brain function, and support healthy aging Unlike other supplements that offer precursors, BrocElite® Plus delivers the actual stabilized sulforaphane molecule, ensuring you receive its full benefits

SAVE UP TO 28% OFF ON YOUR ORDER

OJAI ENERGETICS

Energetics Full Spectrum Hemp Elixir: Fast-Acting, Highly Absorbable CBD

Discover the next level of CBD supplementation with Ojai Energetics' Full Spectrum Hemp Elixir Utilizing advanced water-soluble technology, this elixir is 20 times more absorbable than traditional oil-based CBD products and works in just 30 seconds By encapsulating CBD-rich hemp oil in a nano-sized water molecule, it bypasses the digestive system for immediate absorption and effectiveness

This full-spectrum, organic hemp elixir is free of pesticides and toxins, ensuring you get a pure product that supports your endocannabinoid system Whether you're looking to manage stress, enhance recovery, improve sleep, or support overall wellness, Ojai Energetics offers a superior CBD experience.

RECEIVE A FREE BOTTLE OF CBD SPORTS GEL ($47 VALUE) WHEN YOU ORDER 3 OR MORE BOTTLES, SAVING UP TO $64 ON YOUR ORDER ALL WITH FREE SHIPPING!

C60 PURPLE POWER

Fuel Your Body, Protect Your Cells: Unlock Vitality with C60

C60, also known as Carbon 60, is a groundbreaking antioxidant that supports your body’s energy production and cellular health Designed to neutralize harmful free radicals, C60 enhances mitochondrial function, helping your cells produce energy more efficiently

With benefits ranging from increased vitality and mental clarity to reduced inflammation and cellular aging, C60 is your ultimate ally in achieving optimal health and longevity Backed by scientific research and trusted by health professionals, C60 empowers you to perform at your best, no matter what life throws your way.

READY TO EXPERIENCE THE POWER OF C60? USE CODE DNACO10 AT CHECKOUT TO SAVE 10% ON YOUR ORDER START YOUR JOURNEY TOWARD VIBRANT HEALTH TODAY DON’T WAIT, YOUR BEST SELF IS JUST ONE STEP AWAY!