Southwestern Medical Perspectives Fall 2017

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DANIEL ROSENBAUM, PHD, Assistant Professor of Biophysics and Biochemistry, whose research involves G protein-coupled receptors, membrane protein structural biology, and molecular recognition.


IN JULY, Thomson Reuters reported that 10 of the most highly cited researchers in the world worked at UT Southwestern and were on its prestigious list of the “World’s Most Influential Scientific Minds.” These researchers were determined by analyzing citation data over the last 11 years and “are undoubtedly among the most influential scientific minds of our time.”

Professor of Internal Medicine and Cell Biology, whose research involves fat cells, blood vessel formation, insulin-secreting cells, breast cancer and intracellular protein trafficking.

JOSEPH TAKAHASHI, PHD, Chair of Neuroscience and a Howard Hughes Medical Institute Investigator, whose research involves circadian biology and the discovery of genes that influence behavior. CLINIC AL MEDICINE

ADI GAZDAR, MD, Professor of the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research and Pathology, whose research involves inactivation of tumor suppressor genes,


molecular pathogenesis of human cancers, and the role of DNA viruses in human cancers.

Immunology, whose research involves identifying the molecular machinery that mammals use to fight infections.

SCOTT GRUNDY, MD, PHD, Professor of Internal Medicine, whose research involves cholesterol metabolism, dietary fats, drugs affecting lipoprotein metabolism, human genetics and metabolic syndrome.

DAVID JOHNSON, MD, Chair of Internal Medicine, whose research involves the development of new therapies to treat lung cancer.

ERIC OLSON, PHD, Chair of Molecular Biology and Director of the Hamon Center for Regenerative Science and Medicine, whose research involves microRNAs, muscle development, stem cells and transcriptional regulation. IMM U NOLOGY

BRUCE BEUTLER, MD, Nobel Laureate, Director of the Center for the Genetics of Host Defense and Professor of


BETH LEVINE, MD, Professor of Internal Medicine and Microbiology, Director of the Center for Autophagy Research and Howard Hughes Medical Institute Investigator, whose research involves defining the role of autophagy in health and disease and its regulation at the molecular level. P S YC H I AT RY / PSYCHOLOGY

MADHUKAR TRIVEDI, MD, Professor of Psychiatry, whose research involves evidencebased psychopharmacology and treatment algorithms in mood disorders, functional brain imaging in major depressive and obsessive-compulsive disorders, and neurobiology and psychopharmacology of depression and bipolar disorder.

he fragile nature of the human population was again exposed. By mid-September,

the world’s first Ebola epidemic had spread rapidly through multiple countries in West Africa. The threat of a global epidemic generated panic, fear and misinformation around the world. According to the CDC, nearly 3,000 deaths had been confirmed and the number of Ebola cases in Liberia and Sierra Leone, the countries hardest hit, was predicted to rise to between 550,000 and 1.4 million by January 2015. Dr. Haley, along with members of the Dallas County Medical Society and others, Colorized transmission electron micrograph (TEM) of Ebola virus.



gave media interviews to help allay fears as to how the virus was spread. “The epidemic of fear was really rampant,” Dr. Haley recalled. PUBLIC HEALTH

ON SEPTEMBER 28, Thomas Eric


Duncan, a Liberian citizen, was admitted to Texas Health Presbyterian Hospital Dallas with symptoms of fever, vomiting and diarrhea. He tested positive for the virus days later, becoming the first Ebola patient diagnosed in the United States. On October 4, he began receiving treatments with the experimental drug brincidofovir, but he died on October 8. Two nurses who contracted Ebola from Duncan recovered, suggesting that early detection was critical in battling the disease.

Gov. Rick Perry announced the creation of a North Texas Ebola treatment and infectious disease biocontainment facility. UT Southwestern would provide overall leadership, physicians and nurses; Parkland would provide nurses and support staff; and Methodist Hospital System would provide the physical care facility in Richardson. “UT Southwestern is proud that its expert faculty physicians and nurses are ready to lead in providing the very best care possible while safeguarding the safety of staff and the public,” Dr. Podolsky said.

Dr. Podolsky speaks at a press conference to announce the Medical Center’s joining in a unified response for the care of future confirmed Ebola patients in Texas.