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DATA SCIENTISTS FOR LIFE - AROUND COVID-19 - AROUND MACHINE LEARNING
DISCOVER OUR TOOLS AND DATABASES
To unlock life’s mysteries, scientists rely on a range of resources. Among the 160 databases and software tools developed by SIB Groups, 11 have been identified by our Scientific Advisory Board as of particular importance for life science. These benefit from SIB’s specific support. Discover some stories that exemplify their impact.
Bgee
EPD Genes and genomes
Proteins and proteomes
Eukaryotic Promoter Database
Gene expression expertise
Knowledgebase with expert curation and software tools DESCRIPTION Quality-controlled information on experimentally defined promoters of higher organisms, as well as web-based tools for promoter analysis. HIGHLIGHT Over 190,000 promoters downloadable, analysable over a web interface and viewable in the UCSC genome browser.
Knowledgebase with expert curation and software tool DESCRIPTION Gene expression data including all types of transcriptomes, allowing retrieval and comparison of expression patterns between animals, human, model organisms and diverse species of evolutionary or agronomical relevance. HIGHLIGHT Only resource to provide homologous gene expression comparisons between species.
TYPE
STORY
Lipids
Using EPD to design a gene therapy to fight blindness in mice
Structural biology
By activating silent genes to compensate for defective ones using a CRISPR-Cas9 approach, scientists could improve retinal function and attenuate retinal degeneration in mice. EPD was used to identify relevant promoter regions in the DNA and to design the synthesis of the guiding element of the CRISPRCas9 system.
TYPE
STORY
Using Bgee to help identify clinically relevant variants in patients’ genomes In a recent study, Bgee was used to map conserved sequences across vertebrates, thereby hinting at their functional role: this will help to identify clinically relevant variants in patients’ genomes in the future. DOI: 10.1093/nar/gkz1199
DOI: 10.1126/sciadv.aba5614 BGEE IN A NUTSHELL? WATCH THE INTERVIEW