Treatment of MS in children Management of relapses • i.v. methylprednisolone, 20mg/kg/day to 30mg/kg/day (maximum 1g) for 3 to 5 days • Oral methylprednisolone at a dose of 500 mg for 5 days
Disease-modifying therapy Treatment goal • reduce relapses • disability progression, •
accrual of new MRI lesions
• no evidence of disease activity /NEDA
DMT approved for adult MS are applied in POMS Evidence on effectiveness and safety from observational studies
Le Page E, et al. Lancet. 2015 Sep 5;386(9997):974-81
DMT: disease-modifying therapy; MRI: magnetic resonance imaging; NEDA: no evidence of disease activity; POMS: pediatric onset MS Ziemssen T, et al. J Neurol. 2016 Jun;263(6):1053-65; Bevan CJ, Cree BA. JAMA Neurol. 2014 Mar;71(3):269-70
