0 pactalab 2017 lab of the future

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LAB-of-our-FUTURE

Client first

Prepared for ROCHE, July 2017 UNIQUE – COMPACT - MODULAR

www.PACTALAB.com


Esben Vognsen Jensen

PACTALAB

• +4 years as contractor and developer of cabinets & modular labs [PACTALAB] Own products. Products licensed to partners. Partner portfolios Lab Design & Lab Engineering, 3D space management, EPCM services. Development. Experienced in roles as landlord, EPCM contractor, designer, engineering, developer, manufacturer • +8 years as R&D Lab Capacity Supply Responsible [Novo Nordisk, worldwide] Supporting scientific advancement with Project Governance, Facility Management Services & Asset Management • Greenfield and Rebuild Projects: Cost drivers were standards, repetition, flexibility, adaptability • Tools: Master planning, design guides, applied standards in DK, US and China • Operational: more productive science, technological and innovative ideas brought in play • +1.000.000 sqft unified labs with modularity in floor plans, in labs, in interiors • Key words: Unification, simplifications, competition, red carpet policy: spend where value for money • Corporate results: investments reduced, few greenfield, predictability (in-budget on-time), agility (adaption to R&D needs as capacities, products, regulations and technologies) • The “then-lab-of-the-future”: smaller, unified, simplified MEP, tech-enabled, business focused, proximity oriented, uncompromised focus on COHS, high focus on energy w. equipment farming and milk run lab supplies and unified commodities • Ideas, not realized: modularity in MEP, functional ballroom labs, flex labs, convertible office-into-lab-v.v., 100% milk run lab supplies • +15 years in EPCM execution of production, lab and pilot plants [NNE]

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Martin Singers

PACTALAB

• New contractor and developer of cabinets [PACTALAB] Lab Design & Lab Engineering, 3D space management, EPCM services. Development. • +10 years as Project Manager and Design Manager [Labflex] Supporting scientific advancement with Facility Management Services & Asset Management • +15 years in lab design and project execution: planning, design, supply, installation, commissioning • Experienced in roles as manufacturer, EPCM contractor, designer, developer • Project experience from US, Europe, Africa, Russia, India, China • +500.000 sqft labs and interiors

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www.PACTALAB.com


PACTALAB INC

PACTALAB Inc.

• History

Founded 2017, privately owned Owners: PACTALAB DK (2014), US investors HQ: North Carolina, US.

• Business segments

Laboratory Projects – EPCM, D&E Manufacture and Supply of Casework and Cabinets, Alu/Steel & Wood Pharma, Healthcare, Education, Industry

• Competence map

Lab Design & Lab Engineering, 3D space management, EPCM services GMO, Clean rooms, Reconfigurable laboratories, Innovation Safety, Reliability, Quality, Functionality, Cleanliness, Ergonomics Collaboration. Professionalism in all phases. On-time. In-budget.

• PACTA® [Alu/Steel] PACTA®

FLEXdance™ LC

• Zystm®

[Alu/Steel, Wood] Zystm® LAB: Zystm® CARE:

Flexible adaptable lab benches and utility carts Cabinets for UHPLC Z3 [Free] Z5 [Cantilever], Z7 [Plinth], Fumehoods, Accessories Cabinets, Special products, Accessories

• mattteo® [Alu/steel]

MODU-FLEX ® : Flexible adaptable procedure and supply carts

• Brochures

Corporate Onepager. PACTA-LC. PACTA FLEXdance. Zystm 3 5 7. matteo procedure and supply carts. PACTA TRACKlog

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AIM

PACTALAB

• Client first

• Result • Innovation • Create LAB-of-our-FUTURE

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LAB of the FUTURE

PACTALAB

• Lab of the Future • Always spoken about • Modularity, Flexibility, Adaptability, Collaboration, Simplicity …

• The PACTALAB response is FLEXdance. In combination with facility design, that reflects the ideas behind • With FLEXdance, the MEP will decide the use of the lab. • Distributed MEP • Focused PoU utility outlets • New mobile carts for local supply of low volume utilities • The outcome can be a facility, ultimately flexible and adaptable, with significantly reduced MEP costs. • A Lab-of-the-Future.

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OPERATIVE FACILITY MANAGEMENT

PACTALAB

• Capacity will always be key. Functional capacity = Supply. • Cost will always be key – “the money for the science” must be and will be the driver • Lifetime costs are associated with lifetime operation. Therefore lifetime cost must be key. However we all know, that installed cost may count a bit more in the beginning. • Lifetime cost includes installation, operation, and rebuilds, renovations and modifications. • To assure control over lifetime cost, one team must keep track of the utilization, operation and maintenance of facilities and equipment: the Operative Facility Management Team, OFMT • OFMT continuously aims to increase productivity in all aspects of the lab life • OFMT governance must be accepted by all stakeholders in the organization (owners, scientists, technicians, maintenance staff) • OFMT governs the priorities provided in the management policy, in planning, in realization. Strategies, master plans, design guides and approved supplier lists must be in place. Tools and solutions must be applicable for both greenfield and rebuild projects, as well as for minor retrofits and for daily operation. OFMT must be able to act ultra short term as supply is key. • OFMT, Investment Management, R&D Management and Site Management must be closely tied in a collaboration.

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FACILITY INSTALL

PACTALAB

• Lab space is expensive to install. • The average cost is about €1,000 per sqft for new lab space, which is 100-150% above best-case. • The potential must be revealed by OFMT at time of install. Costs are mainly • • • • • • • •

EPCM Services Site Facilities Landscaping Core & Shell MEP Interiors, fit out Casework Commissioning

6-8% 3-8% 0-2% 35% with variations due to facades and seismic 35% with variations due to kind of operation 15-20% 3-8% 3-5%

• Priorities are 1. EPCM; Apply design guide, assure constructability, assure commissioning in phases 2. Modularity in facility design, repetitive solutions 3. MEP routing 4. OFMT knowledge about solutions that work; bring them in play

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FACILITY OPERATE

PACTALAB

• Lab space is expensive to operate • Facility related costs are mostly (financing not taken into account) • energy, and maintenance • Science related costs are many • Priorities are 1. Hours spent

Lean work procedures Minimum commuting time (work flows, proximities) Minimum waiting time (overview, resource availability, decision power) Predictability (planning, overview, resource availability, decision power) Organizational readiness and agility

2. Acquisition

Apparatus & Instruments “As few instruments as possible, but not fewer” Minimum down/idle time (overview, resource availability, decision power)

3. No redo’s

Errors are costly. Most errors are due to manual handling, or lack of same. Transparency, planning, focus.

4. OFMT knowledge about solutions that work; bring them in play

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FACILITY DESIGN

PACTALAB

• Lab of the future is space designed in accordance to the listed priorities, using solutions that work

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LAB of our FUTURE

PACTALAB

• Grip: • Apply standards. Modularity, in floor plan, in MEP. 80% is standard, 20% not. Planners and architects must be guided in the user processes. Prioritize MEP routing • Grip focus • Space Utilization; driven by code and by COHS, helped by proximity studies and repetitions. Space is the biggest cost driver in design • Proximities in MEP-types; unnecessary MEP-routing is easy-to-pick-low-hanging-fruit • Proximities in function; equipment farming can be applied, shared facilities and ballroom play in combination with a timeslot system can be applied • Four bullets above automatically impact energy consumption • Energy consumption; HVAC and heating cooling are immense cost drivers. Consider sunshine impact, balance unified solutions with excess of install, ceiling heights (as suspended ceilings reduce air change) • Work flows. Material workflow, and personal workflow. Related to proximities, however a single topic: storage space; the more mobile, the more just-in-time, the more space is saved. Milk run procedures will increase in the future, possibly provided by third parties.

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LAB of our FUTURE

PACTALAB

• Grip: • Apply standards. Modularity, in floor plan, in MEP. 80% is standard, 20% not. Planners and architects must be guided in the user processes. Prioritize MEP routing • Grip focus (cont’d) • Flexibility: • flexibility is key, no doubt. But before going too far: • flexibility is very expensive when not applied the right way: Unified repeated installations, with no frequent use. Expensive grid systems covering entire ceilings, where less could work. Steam on all floors, purified water loops on all floors, if not frequently used. • routing is expensive, heat transfer losses are big, maintenance costs are significant. Sometimes skilled labor must be called-in to adapt the flexibility • Adaptability: • Modular zoning and modular MEP allows switching functions, change in use from write-up to lab, from meeting room to control space for ballroom pilot space. • Zoning and local utility supply must become key: • roll-in roll-out less used gasses, water and waste. • wet zones can be omitted, or significantly reduced in numbers

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LAB of our FUTURE

PACTALAB

• Time to market / Speed to market will always be crucial • Time counts from decision taken, to facility taken into use. Facilities and organizations must be prepared for change. • Time is a significant cost driver. Hours to be paid for, postponed income, postponed lessons learned, yes. But also because time calls for changes, for new ideas, for innovations. Not all change is innovative! • Design tools must be applied: • Design guides • Simulation of workflows (personal, material) • Virtual Design & Construction, 3D Modelling, BIM • Simulation of construction processes • Use of PAU, pre-assembled units • Use of modular solutions • Use of laboratory casework as plug-and-play, with no installation time, using flex hoses and quick connects • The biggest cost driver is lack of timely decisions!!!

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LAB of our FUTURE

PACTALAB

• Branding will be key. • as talent may become a short supply • as trustworthy and seamless cooperation with authorities and legal parties become central for realization of rapid changes and adaptions • Branding includes working conditions • COHS, Corporate Health and Safety • Appearance, look and feel • Social factors as cooperation, flexible work hours, openness and transparency become more important • Brand will influence facility design and the use of technologies • The trends are pointing towards more generic and shared laboratory facilities compared to todays’ dedicated and tailor made laboratories - from ‘my’ lab to ‘our’ lab • There will be a need for a successful twist: to “personalize the generic”, as the new generation of scientists are more individually AND socially oriented • Key will be safety, ergonomics, look and feel – and to some degree personalization

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LAB types

PACTALAB

Type of Lab

Description

Lab

Typically 1 or 2 modules wide, 18-30 ft deep. Fixed furniture, wall & island. Hood far from door. Few hoods. The smaller lab is suitable for noisy apparatus, hazardous works etc. Traditional MEP

Open Lab Lab with more fumehoods

The bigger lab is suitable for collaboration, simultaneous operations by same staff, multi operations of same kind, overviewed by small staff. Requires convenient accessibility, transparency, windows to corridor Fumehoods cause big air changes. Use bigger rooms to reduce air velocities. Traditional MEP

Ballroom Flex Lab

Typically 3-5 modules wide, 18-30 ft deep. Mobile furniture, flexible & adaptable. Requires convenient accessibility, transparency, windows to corridor MEP: Few PoU in ceiling, and normal outlets along one wall

Ballroom suitable f. mini pilot Flex Lab Extended

Typically 3-5 modules wide, 18-30 ft deep. As ballroom, but neighboring room must be convertible to control room, with direct access and look-in When high equipment may be in use, suspended ceiling should not be used. MEP: Few PoU in ceiling, and normal outlets along one wall.

Ballroom convertible (Flex) Flex Lab Convertible

Typically 3 modules wide, 30 ft deep. Ideal for 12 write-ups modern standard, or ball room. Not suitable for lab use with high air rates due to risk for draft when used as office MEP: Few PoU in ceiling, and normal outlets along one wall.

Core Labe Equipment farm

Lab for noise and heating equipment. Sizing is mostly limited due to risks: handling of hazardous materials and fire rules. Not suitable for long-term work and therefore preferably located away from attractive areas (center of building, basement)

Collaborative Lab

The collaborative lab is an open lab with convenient accessibility, inside transparency, windows to corridor. Like the ballroom lab, or the open lab; dependent on the needs for furniture and cabinets.

• It all leads to the need for a new solution, mobile adaptable, that also serves as traditional lab furniture. • The PACTALAB response is FLEXdance. • With FLEXdance, the MEP will decide the use of the lab. Distributed MEP, focused PoU utility outlets, and/or new mobile carts for local supply of low volume utilities • The outcome can be a facility, ultimately flexible and adaptable, with significantly reduced MEP costs. 15

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NEXT STEP: LAB of our FUTURE

PACTALAB

• The call for flexibility and adaptability is not new • The call for standards, for modularity, for simplicity is not new • One solution is new • FLEXdance cabinets and carts • FLEXdance utility PoU • Ultimate flexibility and adaptability • One approach is new: • Client first • PACTALAB thinks as a client, because that is where we come from • We will be happy to do a personal presentation • Please visit our brochures, provided on this link:

https://pactalab-my.sharepoint.com/personal/esben_vognsen_pactalab_com/Documents/PACTA%207%20SALESMARKET%20INC/7Q%20US%20Corp%20Transfers/PACTA%20ROCHE

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