SOUTH AFRICAN PHARMACEUTICAL & COSMETIC REVIEW
July 2018 | Volume 45 | Number 7
www.pharmacos.co.za
Nutritional supplements redeveloped with compliance and
consumer safety in mind
SUN CARE: The protection and prevention ingredients Manufacturing tech enables factories of the future
Weighing in on the power of preservatives
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Contents SOUTH AFRICAN PHARMACEUTICAL & COSMETIC REVIEW
July 2018 | Volume 45 | Number 7
w w w.pharmacos.co. za
20
6 NEWS
Novartis tables major GDP contributions in SA
A strong start to 2018 for Evonik
Symrise stays on track with sustainability targets
9 PRODUCTS NEWS
during pneumatic screening
What’s new in South Africa
10 EVENTS
Ensure operator safety
Attend Afriplex’s technical symposium
16 PROCESS & MANUFACTURING TECHNOLOGY
Unilever installs R50 million biomass boiler
New off-site warehouse for Aerosol & Cosmetics Works
Optimise production with Artificial Intelligence
How to ensure operator safety during API screening
Afrox Hi-Q gases for specialised applications
More 26 than routine protection is needed for sun care in Africa
22 SUN CARE
Nimue reveals industry first with Micah technology
Kalichem offers a clear alternative to TiO2
Category insight and formulation solutions
Millennials and sun protection
New polymer increases SPF efficiency
38 PHARMA FOCUS: CAMs & HEALTH PRODUCTS
UV, blue light and IR protection from Lipotec
Improve metabolic syndrome with Metabolaid
Stabil-Lab: a new, independent stability storage facility
34 PRESERVATIVES CPC from Vertellus – an ideal alternative to MIT
Bridge the gap between natural and allopathic medicine
Chemyunion expands Hebeatol range of antimicrobials
A united focus on safe and appropriate regulations
43 The third gREVIEW degree on label Packagin W hat’s hot Volum July 2018 |
e 44 | Number
7
RICAN SOUTH AF
coverage
cos.co.za www.pharma
46
in inks tive and decora finishes
45 Inks & Print Finishes
Solutions to transform ordinary packaging
46 Labelling:
Shrink Sleeves
ISW leads the 360° revolution
48 ASSOCIATION NEWS
sleeves: Shrinrk360 ˚ shelf You shout solution
ay Bosch steps aw g from packagin
The latest news from GBMSA, MCA, Coschem and the HPA
P C Review | JULY 2018 |
3
SOUTH AFRICAN PHARMACEUTICAL & COSMETIC REVIEW
From the editor
THE TEAM
Time to
EDITORIAL Editor: Abby Vorster +27 (0)11 877 6038 abby.vorster@newmediapub.co.za
integrate
T
he global healthcare, beauty
Assistant Editor: Aarifah Nosarka +27 (0)11 877 6209 aarifah.nosarka@newmediapub.co.za Layout & Design: Kirsty Thomas Contributors: Jessica Byrd, Jon Fedders, Jill Gardiner, Kinjal Joshi, Raj Naidoo ADVERTISING
While we’re experiencing a truly cold winter,
and food markets are converging
we cannot forget about sun protection and
into a new consumer products
the newer concept of blue light protection.
category identified as ‘wellcare’
Innovation is a major driver of the new
by PwC’s strategy consulting team. This
technologies featured in our bumper sun
category focuses on a combination of
care feature on page 22. These include
aspects from wellness and fitness to beauty
Hallstar’s Micah, which offers a novel path
and environmental sustainability. It also
to protection; Croda’s Solaveil Clarus
encompasses a broad range of brands
range of UV filters for transparent sunscreen
and manufacturers from various industries,
products for the African market; and DSM’s
such as consumer healthcare, FMCG,
drive to improve sun protection awareness
biopharmaceuticals and medical devices.
among millennials.
Through collaboration these industries are
In our preservatives feature on page 34,
Sales Executive: Carla Melless +27 (0)83 260 6060 carla.melless@newmediapub.co.za Sales Executive: Anita Raath +27 (0)82 976 6541 anita.raath@newmediapub.co.za Sales Executive: Candida Giambo-Kruger +27 (0)71 438 1918 candida.giambo-kruger@newmediapub.co.za INTERNATIONAL SALES Germany/Austria/Switzerland: Eisenacher Medien Erhardt Eisenacher +49 228 249 9860 info@eisenacher-medien.de Italy: Ngcombroker Giacomo Rotunno +39 370 101 4694 g.rotunno@ngcombroker.com
well positioned to offer consumers integrative
we introduce you to two new antimicrobials
Taiwan: Ringier Trade Media Sydney Lai +886 4 2329 7318 sydneylai@ringier.com.hk
beauty and healthcare solutions, yet a
recently launched on the global market. CPC,
CIRCULATION
tendency to operate in silos still exists in
part of the Freshstat family of ingredients from
South Africa.
Vertellus offers an ideal alternative to MIT,
Integrated healthcare is the underlying
while Chemyunion’s Hebeatol CG broadens
theme in this edition’s pharma focus. On
the palette of preservatives available
page 38, we look at how the CAMs and
to formulators.
Circulation Manager: Felicity Garbers +27 (0)21 701 1566 felicity.garbers@newmediapub.co.za PUBLISHING TEAM General Manager: Dev Naidoo
Bosch’s breaking news to step away from
Publishing Manager: Natalie Da Silva +27 (0)11 877 6281 natalie.dasilva@newmediapub.co.za
to enhance healthy living with safe and
selling packaging machinery and equipment
Production Controller: Rae Morrison
effective products. Yet ongoing regulatory
is featured in our regular Packaging
Art Director: David Kyslinger
challenges are stifling innovation.
Review section on 43. Aarifah Nosarka also
JOHANNESBURG OFFICE
discusses new inks and finishes to take your
New Media Publishing, Ground floor, Media Park, 69 Kingsway Avenue, Auckland Park, 2092 Tel: +27 (0)11 877 6111, Fax: +27 (0)11 877 6198 POSTAL ADDRESS PO Box 784698, Sandton, Johannesburg, 2146
health supplements industry is well positioned
If you’re looking for new technology for your manufacturing plant or are interested in
packaging from mainstream to luxurious
the developments at some of the industry’s
and how shrink sleeves offer so much more
leading personal care manufacturers, our
than straightforward self-
process and manufacturing technology
adhesive labels.
feature has all the inside info. Turn to page 16 now to read about Unilever’s new biomass
Published on behalf of Media24 by New Media Publishing (PTY) Ltd. MANAGING DIRECTOR Aileen Lamb
Enjoy the read.
boiler, Aerosol & Cosmetics Works’ recent
CHIEF EXECUTIVE OFFICER
purchase of an off-site warehouse and high
Bridget McCarney
containment pharma screening solutions.
EXECUTIVE DIRECTOR John Psillos NON-EXECUTIVE DIRECTOR Irna van Zyl
EDITORIAL ADVISORY BOARD
HEAD OFFICE New Media House, 19 Bree Street, Cape Town 8001 Tel: +27 (0)21 417 1111, Fax: +27 (0)21 417 1112 Email: newmedia@newmediapub.co.za PO Box 440, Green Point, Cape Town 8051
Consultant, drbaileys.com
Dr Trevor Baillie
Past-President, Society of Cosmetic Chemists SA
Prof Dr Aubrey Parsons
John Knowlton
CEO of the Generic and Biosimilar Medicines of Southern Africa
Professor Emeritus, Faculty of Health Sciences, Nelson Mandela University
Vivian Frittelli
Prof N T (Raj) Naidoo
P C Review is the official journal of: CTFA - The Cosmetic, Toiletry & Frangrance Association of South Africa GBM - Generic and Biosimilar Medicines of Southern Africa
4
Consultant, Cosmetic Solutions
| JULY 2018 | P C Review
COSCHEM - The Society of Cosmetic Chemists of South Africa HPA - The Health Products Association of Southern Africa AMA - The Aerosol Manufacturers’ Association of South Africa
Pharmaceutical Cosmetic Review is published by New Media Publishing 11 times a year and circulates to manufacturers, packers and distributors of pharmaceuticals, health products, cosmetics, detergents, soaps, toiletries and allied products. The journal is an up-to-date source of reference for company directors, factory and production managers, marketing executives, engineers, import agents, buyers and research personnel. While precautions have been taken to ensure the accuracy of its contents and information given to readers, neither the editor, publisher, or its agents can accept responsibility for damages or injury which may arise therefrom. All rights reserved. © Pharmaceutical Cosmetic Review. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, photocopying, electronic, mechanical or otherwise without the prior written permission of the copyright owners. Pharmaceutical Cosmetic Review is printed and bound by CTP Printers - Cape Town. Copyright: all rights reserved. ISSN 0257-8719
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T O G E T H E R, W E G R O W
NEWS
NEW R1 BILLION HIGH CONTAINMENT FACILITY FOR ASPEN
NOVARTIS PUMPS MILLIONS INTO SA’S GDP ALREADY HEAVILY INVESTED in science and healthcare development partnerships across the continent, Novartis contributes around US$150 million to South African GDP each year. This is according to the company’s new CEO, Vasant (Vas) Narasimhan. During his first visit to Ghana, Kenya and South Africa in his new role, Narasimhan outlined financial, environmental and social (FES) impact valuation results for South Africa based on 2017 data. The evaluation indicated a total GDP contribution of US$149 million, with a US$67 direct and US$37 million indirect
s along side Minister Davie and Aspen’s ad Sa en ph Ste nager, capability ma an at the Branson Bosm launch in Aspen facilit y Port E lizabeth
GDP contribution including purchases from vendors along the entire supply chain. The company’s total employment impact exceeds 5 900 jobs in South Africa, with an indirect employment impact of 1 600 jobs. It also delivers a significant positive human capital impact, enhancing the skills and knowledge of healthcare professionals, as well as multiple programmes to build medical research capacity in South Africa. These initiatives include
THE MINISTER OF Trade and
contributes about 0.48 percent
Industry, Dr Rob Davies recently
to the GDP, playing a small
launched Aspen’s high containment
part in the economy and
facility in Port Elizabeth, Eastern
providing employment for about
Cape. Apart from welcoming a new
9 600 people.
era in pharma manufacturing in
‘When we look at global
South Africa, the plant will create an
manufacturing value chains, South
additional 240 jobs.
Africa will be better off if we are
The High Containment Suite
involved in the production of value
(HCS) Unit 4, together with the
added products, even if it is just
investment in a sterile facility,
basic manufacturing rather than
stemmed from a partnership
simply importing,’ he added.
between the Department of
Apsen group chief executive,
Trade and Industry (dti) and
Stephen Saad said Aspen is a
Apsen. The multinational pharma
serial investor in the South African
manufacturer benefitted from
pharmaceutical industry. The
the dti 12i tax incentive with a tax
company is particularly pleased
credit of about R209 million.
that its Capex investment into the
Speaking at the launch, Minister
South African market over the past
Davies said the new plant was a
two years has out-stripped the
significant investment that creates
investments made into the industry
the necessary jobs South Africa
over the past decade.
needs in the manufacturing sector. ‘If we look at the
‘We are pleased that over 90 percent of the jobs that will
pharmaceutical industry, South
be created in the new facility will
Africa’s population is the largest
be local jobs, mostly drawn from
consumer of pharmaceutical
surrounding communities such
products. When we look at some
as New Brighton Township. These
of these statistics, I think we can
employees will go on to become
see there are huge challenges
world class, highly skilled people,
in that we have a huge trade
who can hold their own anywhere
deficit of around R20 billion. This
and, in most facilities, globally.
means we import R20 billion of
A further aspect of our DNA,
pharmaceutical products than we
particularly in pursuit of creating
export,’ said Davies.
a better country, is partnering
The pharma industry from a manufacturing perspective
6
| JULY 2018 | P C Review
with government where possible,’ Saad concluded.
the young physicians’ skills development programme, funding post-graduate studies in clinical epidemiology at Stellenbosch University; the Next Generation Scientist programme at the University of KwaZulu-Natal; partnering on the MSc. in regulatory sciences at the University of the Western Cape and Hibernia College; clinical trials capability building with the University of Cape Town; young scientist training in genetic research in collaboration with Wits University and drug discovery and clinical trials. These clinical trials amount to 28 and involve 1 602 patients across 163 trial sites in the private and public sector. Novartis reached over 667 000 patients in 2017 through its 18 innovative medicines brands and over 5.4 million patients through the nine Sandoz brands, which deliver trusted and affordable products in key treatment areas. The environmental and social return on investment of all Novartis FES initiatives is approximately 300 percent. ‘Over the years in South Africa, Novartis has illustrated its commitment to benefiting patients, the healthcare sector and the economy as a whole,’ says Narasimhan. These efforts are being stepped up on an ongoing basis. According to Novartis South Africa’s country president, Dr Thomas Kowallik, with its three divisions across innovative medicines for pharma and oncology, Sandoz and Alcon, the company has been active in South Africa for over 70 years. Within that time, it has developed a strong clinical trial footprint in the country. Boipelo Mothupi, Novartis SA’s medical sales rep, public sector, public affairs; Vas Narasimhan and Mandla Magwaza, Novartis SA’s business admin learner, human resources
NEWS
Givaudan Active Beauty has created a range of fine fragrances formulated with Revivyl to protect skin microflora
Sweet-Orr launches local protective clothing showroom A MARKET LEADER in protective clothing,
quality and innovative workwear. It ranges
Sweet-Orr has opened a first of its kind
extend from utility casual and denim to essential
showroom in Boksburg, Gauteng, at the Terminal
and highly specialised protective wear. Sweet-
Lifestyle Centre.
Orr has truly made a name for itself with its
Sweet-Orr believes that everyone should be
acid repellent, flame retardant and flame acid
and protective clothing, which is the inspiration
garments, specially developed for low, medium
behind the launch of the local showroom. It
and high risk environments.
will stock Sweet-Orr’s specialised range and its essential and utility workwear. ‘We are passionate about ensuring individual
CUSTOMISED FINE FRAGRANCES PROTECT SKIN MICROFLORA
innovative specialised range, which includes
able to easily access superior quality workwear
‘We’re looking forward to building a closer relationship with the people who wear our garments. Our new showroom gives us the
tradesmen and artisans have access to the
opportunity to do just that. Our motto is “we will
necessary garments and advice from expert
never let you down”, and we work hard to live up
staff. We believe that everyone deserves to
to it”,’ Jacobs adds.
be able to do their best work without putting
The showroom will be open between 08h30
themselves at risk,’ says John Jacobs, MD,
and 16h30 from Monday to Friday and 08h30 to
Sweet-Orr South Africa.
12h30 on Saturdays.
The 150m2 showroom has a fresh, modern appeal that combines Sweet-Orr’s African
Sweet-Orr’s new showroom in Boksburg has a modern look and feel
and American heritage and is centrally located for easy private and industrial sector
A RANGE OF new fine fragrances crafted with
to access. ‘We’ve worked hard to create an
Givaudan Active Beauty’s award-winning
environment and experience that is premium
microbiome protecting ingredient, Revivyl, allows
and professional but also warm and welcoming,’
customers to express and protect their uniqueness.
says Denver Berman-Jacob, executive director,
We are all unique – it’s in our DNA. The
Sweet-Orr South Africa.
same applies to the skin microbiome. This
The company boasts one of the industry’s
is the inspiration behind Givaudan Active
most extensive and diverse selection of high
Beauty’s fine fragrance concept called [Yu], for ‘your uniqueness’. The company randomly selected 10 customers
fragrances based on the olfactive preferences of
Evonik reports a good start to 2018
each winner. These were then expertly combined
THE COMPANY’S ADJUSTED EBITDA
Free cash flow increased to €84 million (prior-
with Revivyl.
increased to €679 million in the first quarter,
year quarter: €57 million) as a result of lower
marking a significant increase of 14 percent
outflows for capital expenditures.
at the Givaudan Active Beauty 2017 VIP party to receive a unique gift – a customised fine fragrance that also protects their skin’s uniqueness. Givaudan Fine Fragrance perfumers crafted these
Each winner received their active perfume in personalised packaging along with their unique
year on year. All three chemicals segments
skin microbiome map.
contributed to the gain in earnings.
Fabrice Lefèvre, the company’s marketing and
‘We are consistently implementing our new
‘In the first quarter of 2018, business in the Middle East and Africa witnessed double digit growth compared to Q1 of the previous year.
innovation director, comments: ‘Givaudan Active
strategy,’ says Christian Kullmann, chairman
That is quite a good achievement, so a good
Beauty is constantly striving to combine active
of the executive board at Evonik. ‘With our
start into the year with enough room to improve
ingredients in revolutionary concepts. Beyond the
focus on innovation and performance oriented
further,’ comments Hendrik Schoenfelder,
concept of “exclusive skin microbiome protecting
corporate culture, we are consistently striving
president of Evonik Middle East and Africa.
fragrances”, we are creating new sources of
for profitable growth. Our goal is a balanced
inspiration for our industry. What if you could
portfolio focused on speciality chemicals.’
express how special you are by your fragrance
Sales grew one percent to €3.68 billion
Despite an increasingly negative currency effect, Evonik is reiterating its forecast and expects to grow sales and operating earnings
and protect your intrinsic uniqueness? These 10
in the first quarter, driven mainly by slightly
this year. Adjusted EBITDA is expected
perfumes are a perfect example of how we create
higher sales volumes as well as increased
to increase to between €2.4 billion and
solutions using the synergies between fragrances
selling prices. Currency effects, especially the
€2.6 billion (2017: €2.36 billion). Thanks
and Active Beauty.’
weaker US dollar, had a counter effect.
to its strong market positions and strategic
Givaudan is the first fragrance house to create
The adjusted EBITDA margin improved to
focus on its four growth engines: healthcare;
a personalised perfume that protects the skin
18.5 percent (prior-year quarter: 16.4 percent).
speciality additives; animal nutrition and smart
microbiota. In South Africa, The Care Co. is
Adjusted net income increased to €333 million
materials, Evonik anticipates demand will
Givaudan Active Beauty’s designated agent.
and adjusted earnings per share rose to €0.71.
remain high.
P C Review | JULY 2018 |
7
NEWS CO M PLIAN CE CO LU M N
Claims – the devil is in the detail Another climate protection first for Symrise THE NUMBER OF companies with scientifically recognised climate targets exceeded 100 for the first time this year. The global Science Based Targets initiative (SBT) certifies the climate targets of interested market participants according to whether they are in line with current research and working to reduce CO2 emissions on par with the standards of the Paris Climate Agreement. Symrise is one of 12 German companies that have participated so far. The Holzminden-based business is ahead of its own schedule when it comes to implementation. In order to have their scientifically based climate targets recognised, the companies submit their plans to the SBT initiative, whose experts examine them in detail. So far, 389 large companies have undergone this test, including many worldrenowned brands. Companies from 23 countries are now pursuing science based climate protection targets. To be approved, interested parties must show their goals correspond to the current state of research. They must also realise the minimum savings necessary (relative to their sector and size) to meet the global objectives of the Paris Agreement. The initiative is supported by the WWF, the UN Global Compact, the Carbon Disclosure Project and the World Resource Institute – an organisation dedicated to environmental protection and resource conservation. A total of 57 of the 103 companies verified so far are from Europe. Only a few German companies can be found on this list. Just 12 companies from Germany have submitted their plans to the initiative and only three of them have received confirmation that their goals meet the SBT’s strict requirements. Symrise’s goals were approved in July 2017 as the 61st company worldwide. By 2030, it plans to reduce its own CO2 emissions by 18 percent. The calculation is based on the values from 2016. The obligation includes Scopes 1 and 2, i.e., the CO2 emissions generated within the company for energy production, as well as those resulting from the purchase of electricity. To achieve the targeted CO2 reduction, Symrise had to reduce annual emissions by five percent. Yet a much larger step was taken in 2017 with the company’s sustainability report showing a decrease of 7.8 percent. The next interim goal is to halve CO2 emissions in relation to value added by 2030, based on the figures from 2016.
8
| JULY 2018 | P C Review
In the March column, Jill Gardiner looked at general criteria for ensuring claims are made in a cosmetic and not a medicinal sense. Now Gardiner tackles specific problem areas where competitors often tend to walk the fine line between acceptable and unacceptable claims.
A
nti-dandruff claims are one of those areas that can leave you with more than a sprinkling of dry skin on your shoulders if you err on the side of unacceptable claims. An advertisement shall not claim or imply a cosmetic product can cure or permanently prevent a specific condition that is the symptom of a disease. The advertisement shall state the condition can be alleviated by regular use of the product. Cellulite claims are another bumpy road to navigate. Claims that make reference to the removal of cellulite, weight loss or slimming are not allowed. Skin lightening claims are not permitted. A product may not claim to bleach, whiten or lighten the skin. For claims of this nature, using the term ‘even tone’ could be a good option. Sunscreen products come with their own burning issues. Claims for UV protection must be qualified with reference to UVA or UVB protection or both. Claims shall not be made or imply 100 percent protection from UV radiation e.g. block, sun blocker or total protection. The claims ‘waterproof’ and/ or ‘sweat resistant’ are not permitted. Pixie dust quantities provide no fairy tale ending when claims are made for ingredients. Mention of ingredients may be made but if specific claims for such ingredients are made, adequate and verifiable evidence, such as by demonstrating the presence of the ingredient at an effective concentration, must be provided to prove the product itself has those properties. Non-content claims are a ‘much ado about nothing’, though punting the fact a product does not contain an ingredient is tricky business. Non-content claims should be allowed as long as the following key criteria are respected: • It is not the main argument of the product but provides additional information to consumers. • It is fair and not misleading, especially with respect to the ingredient or ingredients that are the subject of the claim being made. • It is relevant for the product category (any XXX-free claim is not acceptable when XXX is either forbidden or would not form part of a relevant cosmetic product. So, the devil really is in the detail unless you are highly versed regarding unacceptable claims for specific categories. •
STREET The essence of men
Rain Africa has diversified into male grooming with an extensive series of products. The shaving milk has jojoba and marula oil, the aftershave gel includes skin soothing aloe ferox and there is a refreshing aftershave spritz. Additional offerings include a beard oil, deeply hydrating body butter, hand and body lotion, face cream, olive oil soap on a rope, hair and body wash, fragrant shower gel, shaving cream and olive oil shaving soap, and an eau de toilette. The packaging was designed to reflect the natural origins of the range and is masculine and sophisticated to resonate with the male consumer.
Soothing micellar cleanser Vichy’s new Pureté Thermale three-in-one micellar solution. This time saving cleanser purifies and soothes the skin while removing makeup and pollution particles in one simple step. It offers an effective, quick and gentle way to cleanse skin without rubbing and rinsing. This refreshing ultra gentle cleanser has a waterlike texture. The formulation is non-sticky, non-oily, suitable for sensitive skin and enriched with
Anti-inflammatory gel
hydrating pro-vitamin B5 and mineral water.
Adding to South Africa’s most prescribed muscle relaxant brand, Norflex, by iNova Pharmaceuticals has launched an antiinflammatory Benzydamine Hydrochloride topical gel. Norflex Gel is the first of its kind in South Africa and provides patients with symptomatic and topical relief associated with painful inflammatory conditions. The gel has anti-inflammatory, analgesic and local anaesthetic properties and is available from leading pharmacies in 30 and 75g pack sizes.
New from Phyto Pro A three in one Energiser and Nitro Blast are the two new additions to the Phyto Pro line-up of sports nutrition products. The simple yet effective three in one Energiser is based on plant-derived ingredients such as whole-fruit powdered mango; rhodiola, green tea and green coffee bean extracts; potassium; magnesium; calcium; vitamin C;
Keep skin hydrated Celltone has launched a range of tissue oil body lotions and body butters in three unique scents. The coco butter lotion
malic acid and stevia. Nitro Blast is a strawberry flavoured nitric oxide boosting product in a powdered drink format. Its key ingredient is Shilajit, an ancient Ayurvedic superfood with highly concentrated, bioavailable antioxidants, minerals and phytonutrients. Phyto Pro products are sold in Dischem stores nationwide.
and body butter are richly nourishing and smells great. The camphor variant is not only comforting but also nourishes, hydrates, protects and repairs dry
and damaged skin. There is also an original tissue oil body lotion and body butter, which are both based on Celltone’s popular tissue oil product. These products are available at independent pharmacies and major retailers such as Dischem, Clicks, Pick ‘n Pay, Game, RED Square and Edgars.
P C Review | JULY 2018 |
9
EVENTS
Harness nature’s best at
Afriplex’s technical symposium Back by popular demand, Afriplex will be hosting another one of its sought after one day technical symposiums at the JSE Conference Centre in Sandton, Johannesburg, on 12 September.
based clients. The international and
• an update on current regulations
local speakers have been carefully
and legislation
selected to ensure delegates receive
• innovation regarding APIs
maximum benefit from their insights into the trends and opportunities in today’s challenging market.’
• latest developments in CBD
DID YOU KNOW?
(Cannabidiol) legislation and how to incorporate this ‘controversial’ ingredient
TBuyer’sguide into a final product.
ingredients, taking us back to
regulatory and active
THE
will explore the benefits of natural
Afriplex is a South African company Afriplex looks forward rooted in the development and to spending the manufacture of botanical extracts, CAMs and food and beverage product The programme will day with its clients solutions. The company’s manufacturing cater for all existing and partners and to plant is based in Paarl, in the and potential clients share its experience Western Cape, with a newly and partners in the and knowledge about established regional office CAMs, health supplement, current and relevant in Johannesburg.
he theme for this year’s symposium is ‘Harnessing Nature’s Best’ and
Symposium highlights
the efficacious preventative care that
pharmaceutical ingredient
nature offers.
(API) categories of the pharma and
Wayne Robinson, Afriplex’s director of
business bevelopment, says: ‘This year, we are thrilled to be able to showcase our technical symposium to our Gauteng
nutraceutical industries.
The following topics will be covered: • local and international trends in the CAMs and health supplements
topics, providing an
2017/2018
opportunity for the industry to
learn together.
If you would like to attend this event,
please send an e-mail confirming your interest to LaurenM@afriplex.co.za to be shortlisted for an invitation. •
THE
Buyer’sguide 2018/2019
The directory for manufacturers of food, beverages, pharmaceuticals, cosmetics, toiletries, packaging and the printing industry
Available online: www.thebuyersguide.co.za 10
Buyers Guide 2018.indd 1
| JULY 2018 | P C Review
2018/05/07 3:09 PM
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Full Name:........................................................................................... Designation: ........................................................................................ Company: ........................................................................................... Postal Address:................................................................................... .................................................................Code:................................. Country: .............................................................................................. Tel: (
)....................................... Fax: (
) ..................................
Coschem Scientific Conference: Beauty in HD
E-mail:.................................................................................................
5 to 6 September Bytes Conference Centre, Midrand, Gauteng www.coschem.co.za
Approximate number of employees: ..................................................
IFSCC 2018 Congress 18 to 21 September The Dolce Munich, Germany www.ifscc2018.com
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AMA Golf Day
Bank:
19 September Glendower Golf Club, Johannesburg www.aerosol.co.za
Africa Home and Personal Care Markets
Acc No:
CPhI Worldwide
9 to 11 October IFEMA, Feria de Madrid, Spain www.cphi.com
New Media Publishing (Pty) Ltd .
Nedbank Seapoint
1069321540
Branch Code: 10-69-09-00
❑
Credit Card (Mastercard & Visa only) Name of card: ............................................................................. Expiry Date: ................................................................................
26 to 27 September JHB venue TBC www.bit.ly/2GaAUHI
October
Direct Deposit (Fax this form together with a copy of your deposit slip to: +27 086 529 6468
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TAX INVOICE REQUIRED Note: The above prices are applicable to South Africa only. International rates available on request.
P C Review | JULY 2018 |
11
COMPANY FOCUS
A powerful rebrand
with complete compliance in mind Sometimes an older, established brand needs rejuvenation to reinvent itself for renewed success in the market. Assisted by Hersol Manufacturing Laboratories and select packaging and ingredients suppliers, Rejuvenesse, an established line of CAMs and healthcare products, recently rebranded. Abby Vorster shares Claudi Ten Cate’s story about how she brought new life to this old brand.
R
ejuvenesse has been on the market for the past 25 years. This well-respected and successful healthcare brand originally consisted of 24 diverse products focused on stomach concerns, joint and bone health,
cholesterol and feminine health to name a few. In February, the brand officially changed ownership, yet Ten Cate stepped in as brand manager over a year ago to rejuvenate Rejuvenesse, bringing this well-known brand back to its former glory while moving with the times. ‘We’ve rationalised the brand down to 18 products to retain listings at various retailers and returned to Hersol as the original manufacturer,’ she explains. ‘As a contract manufacturer, the company played a significant role in the rebrand, appointing key suppliers to support my vision for the changes.’ Ten Cate has a strong background in consumer science and nutritional and functional food. She is also passionate about health and wellbeing, which is evident in the new range of Rejuvenesse products. ‘The changes essentially focused on patient care, consumer safety and regulatory compliance. While certain products were reformulated, raw material substitutions were required on others as a result of dwindling supply and quality issues,’ she adds. ‘Thanks to Hersol’s extensive expertise in the changing regulations and what will be required of CAMs and health products going forward, the company guided the brand on how to be compliant.’ Rejuvenesse products are based on supportive healthcare so there are no claims on the packaging. Another key compliancy change was the updated patient information leaflets (PILs) with the necessary disclaimers and font sizes now required by the South African Health Products Regulatory Authority (SAHPRA). Also a SAHPRA requirement, all of the products include a description of the key active pharmaceutical ingredients (APIs) on the packaging to educate the consumer on why it’s been included in the product. ‘Ultimately, we’re empowering the consumer to make an informed choice about what they are purchasing.’
Packs with a punch Rebranding is a slippery slope so Ten Cate opted for a complete brand overhaul, changing the product’s packaging and labelling with the help of trusted and reliable suppliers. She developed the new identity for Rejuvenesse and turned to graphic designer, Janine Terblanche of the Little Blue Owl House, to bring her ideas for attractive, bold and unmistakable packaging to life. Ten Cate hand-drew the logo, based on the unfurling of a koru fern, which was then refined by Terblanche. The circular
12
| JULY 2018 | P C Review
COMPANY FOCUS
DID YOU KNOW?
shape of the koru, a leafy plant native to New Zealand and a traditional Mauri symbol, conveys the idea of perpetual movement and is symbolic of change. The logo
The South African CAMs and health as well as the logo supplement market continues to grow, that appears on the fuelled by higher levels of consumer awareness side of the pack. about well-being and preventative healthcare. There are 10 Immune boosting supplements and probiotics have gained massive popularity because product families boosted immunity and good digestive in the range of 18 health remain high on consumers’ products and each health ‘wish list’. Source: is colour coded. This is www.insightsurvey.co.za carried throughout each
symbolises the brand’s payoff
product from the secondary
line – ‘as life unfolds’ – ensuring
carton and labelling of the primary pack right to the actual tablet, capsule or effervescent tablet that is ingested. The unique colour coded tablet coatings are achieved using the innovative FlexiCoat technology from Sensient Colors. The FlexiCoat formulation is spray dried onto the tablets in a single application in Hersol’s state of the art coating equipment that delivers fast, flexible and consistent coating performance. FlexiCoat matches
A pink FlexiCoat from Sensient Technologies is used on the Menosure tablets for colour coding consistency within the Feminesse product family
the brand promise is aligned with the brand delivery, which Ten Cate says is to ‘support consumers throughout life as it unfolds and brings with it some surprises’.
packaging colours and appearance and improves consumer appeal. For the products packed in capsule format, the various colour coded capsules
The labels are printed with a gloss
are supplied by Solo Chemicals. This
varnish by Java Print. Britepak, a
Johannesburg based company also
specialist in producing packaging for
supplies pharma APIs, antioxidants,
pharma and CAMs applications, prints
ingredients for sports and animal nutrition,
the cartons and PILs. The cartons are
probiotics and prebiotics, nutritional lipids
interior printed with a series of luxury
and oils and herbal extracts.
finishes on the exterior to create shelf appeal. These include a matte laminate
With compliance comes trust
on the white and a UV varnish on the
Though Rejuvenesse products like the
colour, as well as a debossed logo to
Serenex and Cholesterex ranges and
add texture to the packaging. To grab
Spirulina already have a notable support
consumers’ attention, the brand name Print Ad.pdf 1 foiled 2018/06/26 on the frontSolo of the pack has been
base amongst consumers and healthcare 09:51
professionals, Ten Cate wanted to offer
Rejuvinate your brand Solo is a niche ingredient supplier who collaborates with manufacturers to ensure the best products and services to our customers. C
M
Y
CM
MY
CY
CMY
K
www.sologroup.co.za
P C Review | JULY 2018 |
13
Hersol has invested heavily in its laboratory facilities. This is the manufacturer’s second instrument lab
COMPANY FOCUS
more in terms of safe, quality and effective products. This is the main reason why the manufacturing of Rejuvenesse has returned to Hersol to be produced in line with Good Manufacturing Practices (GMP). Hersol’s bid to obtain full GMP-accreditation is ongoing while still holding onto its CAMs GMP status from the MCC. The company has developed a strategy to become the best contract manufacturer in the market in terms of service delivery, quality and its ability to develop effective products from concept to market in a short space of time. In addition to extensive manufacturing capacity enhancements, Hersol installed a world class microbiological laboratory in 2017 for analytical development and validation, including stability studies. This is also where all raw materials and ingredients, such as those supplied by Enna Industrial Ingredients (Enna II), are tested to validate their quality and efficacy. An example is Pomanox from Probeltebio which Enna II supplies to Rejuvenesse. This patented natural extract obtained from fresh pomegranate grown in Spain has proven cardiovascular health benefits. With vertical integration, quality control and full traceability at the heart of how Pomanox is produced, Enna guarantees Probeltebio’s product is of a high quality and free from organic solvents, synthetic chemicals and radiation. This strict protocol doesn’t only apply to Hersol’s suppliers – it applies to all its customers too because the company insists everything it manufactures is done according to legislation and within the standards prescribed. Ten Cate says this disciplined focus helps Rejuvenesse keep its promise to the consumer that all its products are compliant. ‘With Hersol’s guidance, we have gone above and beyond to ensure the safety, quality and efficacy of Rejuvenesse which includes stability testing the products for two years. We want consumers to trust the brand because it offers safe and effective products and we want to ensure these products remain on shelf once the regulations have been promulgated,’ she concludes. There is no official date for the Rejuvenesse relaunch, yet phase one of swapping out old stock for new commenced on 1 June. This means you can already see the first 13 products of this rejuvenated CAMs brand on shelf in major retail pharmacy outlets and other pharmacy and wellness stores nationwide. •
Britepak – www.britepak.co.za Enna Industrial Ingredients – www.ennaii.co.za Hersol Manufacturing Laboratories – www.hersol.co.za Sensient Colors – www.sensient.com Solo Chemicals – www.solochem.co.za
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| JULY 2018 | P C Review
ADVERTORIAL
J
Introducing the Povidone Family product line from JRS PHARMA
RS PHARMA has announced the worldwide release of the Povidone Family product line, the latest addition to its excipients portfolio. This product line consists of three offerings: 1. V IVAPHARM PVP (Povidone), the classic wet binder with optimal balance between adhesive strength and ease of handling 2. V IVAPHARM PVP/ VA 64 (Copovidone), the ultimate tablet binder for all processing technologies 3. VIVAPHARM PVPP (Crospovidone), offering unsurpassed disintegration performance and versatility.
“A significant emphasis has been placed on stringent quality control” Dr Gernot Warnke, JRS PHARMA’s global director of R&D, comments: ‘I am excited about the addition of povidones to the portfolio, which strengthen our offering in the field of tablet binding and disintegration. The Povidone Family significantly
contributes to building the most comprehensive range of solid dosage form excipients on the market.’
QUALITY ASSURANCE AND SPECIFICATIONS Manufactured in a state-of-the-art GMP and ISO 9001 compliant/certified production facility, the VIVAPHARM Povidone range complies with the current Povidone, Copovidone, and Crospovidone monographs in Ph. Eur. 9.0, USP39/NF34 and JP17/ JPE, respectively. The specifications for the VIVAPHARM Povidone range are set tighter than compendial limits to better meet customers’ requirements. A significant emphasis has also been placed on stringent quality control. In addition to on-site quality checks, VIVAPHARM Povidone products will go through final quality control and release in the newly established Analytical Competence Centre at the JRS PHARMA facility in Germany. The Povidone Family product line is available locally from Rettenmaier South Africa, JRS PHARMA’s local office responsible for subSaharan Africa.
PRODUCTS AND SERVICES TO BRING HEALTH SCIENCE TO LIFE JRS PHARMA is a leading manufacturer of excipients, offering a complete portfolio of solutions for the global health science industry. Its excipients portfolio includes high functionality excipients, binders, disintegrants, lubricants, functional fillers, thickeners, stabilisers, carriers and coatings. JRS PHARMA also offers excellent technical support and biopharma services to address the needs and formulation challenges of its customers.
RETTENMAIER SOUTH AFRICA
(Pty.) Ltd.
Fibers designed by Nature A Member of the JRS Group
Rettenmaier South Africa Phone: +27 (0)11 534 8619 E-mail: Sales@Rettenmaier.co.za www.jrspharma.com
P C Review | JULY 2018 |
15
PROCESS & MANUFACTURING TECHNOLOGY
FMCG manufacturer makes a
major switch to renewable energy On 5 June, World Environment Day, Unilever South Africa unveiled a R50 million biomass boiler installation at its historic Maydon Wharf Factory in Durban. This marks another significant step in the multinational’s journey to change the way the world does business.
and total plant control
T
commissioning,’ says Phahle
and automation. ‘We had the full support of a Vyncke mechanical engineer during the installation and a dedicated Vyncke software engineer was on site during
he unveiling was attended
leading commitment to ensure all our
Phalane, Unilever South Africa’s
by deputy minister of
plastic packaging is designed to be fully
sourcing unit director: Maydon
Environmental Affairs, Barbara
reusable, recyclable, or compostable by
Wharf and Phoenix.
Thomson; the KwaZulu-Natal
2025. We will also increase the recycled
Because a biomass boiler
MEC for Economic Development,
plastic content in our packaging to 25
is very large equipment,
Tourism & Environmental Affairs,
percent by 2025,’ he adds.
he says work had to be
Sihle Zikalala; and Unilever South
done by qualified riggers
Safety and sustainability
Africa’s executive vice president, Luc-
The new biomass boiler is illustrative
Olivier Marquet. ‘The biomass boiler will reduce CO2 emissions, waste to landfill and ultimately the amount of electricity used in production at Maydon Wharf,’ Marquet explains. He also signed the company’s global commitment to ensure all of its plastic packaging will
DID YOU KNOW?
of the seriousness of Unilever
‘Safety and quality are an important and integral
South Africa’s commitment
part of our manufacturing
to sustainable living. ‘The
standards. A safety officer,
Unilever Sustainable The new biomass boiler Living Plan (USLP), which at Unilever’s Maydon Wharf Factory will consume on average commits to reducing our 940t biomass per month – environmental impact roughly the weight of 375 by half by 2020, has medium sized African already been unveiled,’ says elephants.
be fully reusable, recyclable, or
to maintain safety on site.
Marquet. ‘This goal can only be
achieved by putting sustainability
construction supervisor and project technician were on site for the duration of contract,’ Phalane explains. Daily safety talks were conducted and focused on the work planned, risks evaluated and method agreed.
at the core of our strategy. An important
This resulted in zero safety
part of this is to manage our electricity
incidents for the duration of
of growing concerns about plastic
and water use and to ensure no non-
the construction, installation
pollution – and because it is the right
hazardous waste goes to landfill. The
and commissioning of the
thing to do. In 2017, we made an industry
biomass boiler is our latest step on
biomass boiler.
compostable by 2025. ‘We have undertaken this because
this journey.’ Vyncke supplied and
‘Our service provider, AESAfrica was also instrumental
installed the biomass boiler.
in commissioning the boiler
This global company designs
to ensure its efficiency and
and builds green energy
compliance with air emission
plants. Its solutions span
standards,’ he adds.
fuel storage, chimneys,
AES-Africa operates,
combustion and boiler
maintains and manages
technology, flue gas
energy and utility plants
cleaning, power generation
throughout South Africa on behalf of
Deputy Minister Barbara Thompson, MEC Sihle Zikalala, Unilever’s LucOlivier Marquet and Phahle Phalane at the unveiling of the environmentally friendly biomass boiler
16
| JULY 2018 | P C Review
industrial users across various industries. Its outsourced operations include the
PROCESS & MANUFACTURING TECHNOLOGY
While the boiler cost R50 million to install, we estimate it will provide a saving of around R17 million per year
Phahle Phalane, deputy minister Barbara Thompson and Luc-Olivier Marquet outside Unilever South Africa’s soap factory at Maydon Wharf, Durban
to have”, but rather as essential to our social impact as a purpose led business,’ says Marquet. The success of the biomass boiler will not be the end of Unilever South Africa’s environmental efforts at Maydon Wharf. The company is actively looking at how to
takeover of existing energy and utility
reuse condensate, heat, water waste and
operations, as well as upgrades to or new
flash steam within its factories, as well as a
build energy plant operations.
new soap-making technology that use less
The boiler is fuelled by wooden pallets, waste wood and off-cuts from local furniture and door manufacturers, reducing the amount of wooden waste traditionally sent to landfill. Wooden pallets used as part of ‘business as usual’ by Unilever South Africa are reused and do not form parts of the biomass feed.
energy in production. It is also examining the feasibility of a new drier vacuum and solar power. ‘While the boiler cost R50 million to install, we estimate it will provide a saving of around R17 million per year. This figure factors in fuel savings and will reduce the facility’s carbon footprint. The boiler will lead to a reduction of over 30 percent in CO2
Leading by example ‘If sustainability is integrated into the very core of Unilever South Africa’s business, it’s far more likely it will have a successful impact on the company’s plans to make changes. ‘We don’t view it as a “nice
emissions and is projected to save 14 000t of CO2 every year,’ Marquet concludes. •
AES – www.aes-africa.com Vyncke – www.vyncke.com
Aerosol & Cosmetics Works, your private label personal care manufacturer, is growing! We have just moved into our new warehouse and training facility, so our customers can grow with us.
Two premises – one goal: exceeding customer satisfaction! Phone: +27 21 933 2600/8/9 | Fax: +27 21 933 8818 Email: info@aerosolcosmetics.co.za | www.aerosolcosmetics.co.za Aerosol & Cosmetics Works.indd 1
2018/07/04 10:29 AM
P C Review | JULY 2018 |
17
PROCESS & MANUFACTURING TECHNOLOGY
Aerosol & Cosmetics Works
spreads its wings
A leading South African private label manufacturer, Aerosol & Cosmetics Works, is expanding at a notable rate. The company recently purchased a new off-site warehouse and streamlined its manufacturing facility for improved productivity.
O
n 1 June, Aerosol & Cosmetics
development to services and administration. Of
Works inaugurated its new 2 000m2
the current 173-employee workforce, 169 are of
warehouse and training facility,
previously disadvantaged designated groups.
equipping its employees to apply
and improve the company’s just in time stock system as well as unique SKU location processes. The new warehouse is
DID YOU KNOW?
company is a leading producer of aerosols. Aerosol manufacturing requires a semi-skilled to technically
With its streamlined manufacturing plant and new off-site warehouse, Aerosol & Cosmetics Works is expected to increase its annual manufacturing and distribution capacity of 12 million units of personal care products.
located about 150m from the manufacturing plant in Beaconvale in the Western Cape. This means the company will now have two centres, each focused on a different requirement yet
and professionally qualified workforce. Comprehensive training is a key component of ensuring the company’s systems and procedures stay relevant to international trends. ‘Our supplier relationships, their support and commitment enable us to constantly
aligned to one goal of exceeding customer satisfaction.
improve the status quo,’ says Mark Woods, director at Aerosol & Cosmetics Works. ‘It is in
Aerosol & Cosmetics Works’
Mark Woods and Terrence Fillies, owners of Aerosol & Cosmetics Works
Apart from personal care products, the
my nature to always want to create something
manufacturing plant will continue to address
new out of nothing. Without research and long
and serve the cosmetics, personal care and
hard hours of effort, there is no such thing as a
aerosol product needs of customers, while
quantum leap – no matter how great the talent
its warehouse will ensure on time deliveries.
or efforts of our employees, some things, like targeted growth, do take time.’
An empowered workforce Works’ first focussed manufacturing plant
Solid investments and sustained growth
since the business opened its doors in 1990.
Since 2012, the company has seen an
It represents the company’s economic
annual increase in its product ranges and
commitment to the Western Cape economy,
sustained volume growth is predicted for its
where it has created 173 semi-skilled, skilled and
product offering.
The Beaconvale facility is Aerosol & Cosmetics
technical jobs for people from the region. Their positions range from manufacturing
Each and every employee of Aerosol & Cosmetics Works is proud and excited to celebrate its growth with the opening of the new facility. ‘We are continuing our growth in South
operations
Africa as well as developing our footprint into
and product
Africa. We know and trust that our services and contribution make a difference. We have invested significant time and resources in our people, facilities and procedures and we look forward to developing our business and creating increased value to our customers for decades to come,’ Woods concludes. •
Aerosol & Cosmetics Works – www.aerosolcosmetics.co.za
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| JULY 2018 | P C Review
PROCESS & MANUFACTURING TECHNOLOGY
How adaptive algorithms create new ways to optimise production Artificial Intelligence (AI) in the engineering sector is gaining momentum. This is owing to increased processing power and the availability of increasing volumes of data. Omron offers innovative solutions to automate factories.
I
n the case of the advancements
Overall Equipment Effectiveness (OEE). This
AI algorithms is underdetermined. A reliable
results in combined reduced costs with
operation can only be confirmed through
increased productivity.
testing, optimisation and over dimensioning.
Many of the AI solutions advertised on have significant requirements in terms of
HOW TO DESIGN AND INTEGRATE AI
infrastructure and IT. These solutions also
According to Omron, algorithms integrated
work with an overwhelming amount of
in the machine’s control system create the
data that is laborious and time-consuming
framework for real-time optimisation, at
to prepare and process. The question of
the machine, for the machine. In contrast
added value often remains somewhat
to edge computing, where individual
murky for providers, who cannot determine
manufacturing lines or sites are analysed
whether and how the investment in AI will
using limited processing power, the AI
provide a return.
controller used by Omron, features adaptive
the market, which are often cloud-based,
System designs for the engineering
intelligence. It is closer to the action and
predictive maintenance and networked
sector are generally both complex and
learns to distinguish normal patterns from
efficient production, the use of adaptive
unique. As a result, it is not a matter of
abnormal ones for the individual machine.
required for Industry 4.0, such as
algorithms offers enormous potential. Many manufacturing companies realise AI presents an opportunity to increase
simply transferring learnt experiences
The AI controller integrated in the Sysmac
from other machinery as may be the
platform, which is a complete solution
case for mass-produced products in the
for factory automation, features modules
consumer goods industry. The majority of
for control, motion and robotics, image
systems are generally so complex that it is
processing and machine safety. These
not possible to map out the entire system
are primarily used in the manufacturing
mathematically and maintain costs at an
process at the points where the customer
acceptable level. It is Omron’s view that a
is experiencing the greatest efficiency
‘black-box approach’ is more common. The
problems such as bottlenecks. The
available data in these systems for typical
processes gain intelligence based on
Single solution
previous findings and improvements that have been made and subsequently drive holistic optimisation of the entire manufacturing process. •
The guiding principle behind the Sysmac automation platform is the use of one controller for the entire machine.
Omron – www.industrial.omron.co.za
Superior image sensing speed and precision FH Series
• High-precision object detection • Ultra-high-speed searching • Flexible functionalities to provide high compatibility with manufacturing machines
Would you like to know more? +27 (0)11 579 2600 info.sa@eu.omron.com industrial.omron.co.za fh_series_177x65_ad_enza_01.indd 1
11-06-18 09:42
P C Review | JULY 2018 |
19
PROCESS & MANUFACTURING TECHNOLOGY
Ensure operator safety during pneumatic screening Howorth Air Technology collaborated with Russell Finex to provide a contained pharma screening solution to an international manufacturer. Together they produced a customised solution that prioritises operator safety.
S
ince traditional powder screening machines often don’t provide the levels of containment required to ensure operator safety, the pharma manufacturer previously had concerns about operator exposure during the processing of APIs. Two systems for pneumatic screening and
NEW TO THE AFRICAN MARKET HOWORTH IS BASED in the UK with offices in the USA and representation in Europe and Asia. The company is customer focused, providing bespoke products and turnkey systems to meet the requirements of cleanrooms, R&D and testing laboratories, pharma manufacturing facilities and operating theatres. The company is interested in growth in the African market and recently sold some of its Biogen decontamination equipment in South Africa, through
conveying of pharma powders were required to guarantee containment during
the World Health Organization, to the Desmond Tutu HIV
sieving in two key production areas.
Centre – based at the University of Cape Town’s faculty of
Paul Stanway, business development manager at Howorth comments: ‘The
health sciences.
customer required a DownFlow containment booth, incorporating blending, weighing and sieving. A containment isolator, also known as a glove box, was also required to sieve and weigh APIs in a fully contained environment.’ Howorth’s Worksafe containment booths provide high levels of operator
This custom-built containment powder screener provides all the benefits of vacuum-conveying
protection. They are ergonomically and hygienically designed to allow for multiple
sieve technology with the patented twist, lock and
process operations. For this specific process, pharma powders would be pre-
inflate (TLI) airlock clamping system – ideal for
weighed, transferred into a hopper then vacuum-conveyed into an IBC via a
pharmaceutical sieving in a glove box. An additional
sieving system, ensuring the product is screened to guarantee a consistent particle
inlet was incorporated to allow for manual scoop-
size and remove oversize and foreign contamination. An interior view shows the access point via the glove box in the background with the Russell Compact Airswept Sieve in the foreground
feeding of powders on a smaller scale. To further improve usability, Howorth’s glove boxes have an
Integrated systems
integrated clean-in-place system with hygienic spray
For over 150 years, the Howorth name has been
balls and a wash hose to allow easy wash-down of
synonymous with creating safe and clean working
equipment after use.
environments. The company has a wealth of experience in combining containment
A reliable partner
technology with specialist equipment. For
The Russell Compact Airlock Sieve TLI clamping
this installation, a Russell Compact Airswept
system provides effortless operation whilst maximising
Sieve was specified as the integrated system
screening performance. It requires significantly
of choice. This sieve combines industry
less space than alternative clamping methods.
proven Russell Compact Sieve technology
The operator simply places the component parts
with vacuum conveying lines, ensuring
into the base and locates them by twisting and
powders can be check-screened in one
locking the lid. An inflatable seal then locks the
dust-tight operation. The unit is also quick
components in place. This reduces the dust and
and easy to dismantle, reducing downtime
improves the operator’s health and safety, providing
between processes.
OEL 5 containment (less than one microgram per
Howorth also engineers high containment isolators to provide fully contained
cubic meter). Stanway adds: ‘We chose to work with Russell
environments for API handling. These systems
Finex on this project because of its wide range of
combine containment to nanogram levels with
compact pharma screening equipment. Russell
integrated equipment to provide maximum
Finex also provided invaluable support during
production, ergonomic and maintenance
the design and mock-up phase. When providing
efficiency. For the containment isolator process,
premium custom-built solutions, it is imperative the
APIs would be loaded into the isolator utilising
integrated equipment is of a high quality, operator
a drum-loading chamber with the product
friendly and versatile to meet specific functions and
vacuum-conveyed and sieved, then deposited
environmental demands.’ •
into the same IBC. For this project, a hybrid sieving system was engineered, combining a Russell Compact Airswept Sieve with the Russell Compact Airlock Sieve clamping system.
20
| JULY 2018 | P C Review
Howorth Air Technology – www.howorthgroup.com Russell Finex – www.russellfinex.com
PROCESS & MANUFACTURING TECHNOLOGY
HiQ – the high value
industrial safety offering Precision matters at Afrox. Hans Strydom, the company’s technical services manager for special products and chemicals, talks to P C Review about its meticulous HiQ range of innovative solutions and how they are tailored to suit customers’ speciality gas and equipment requirements.
A
t Afrox and all other Linde
gas utilised must accurately mimic the
companies around the world,
polluting gas the instrument needs to
HiQ is the global brand for
monitor. Getting the measurement wrong
a specific range of made-
can be costly, with potential fines. Low
for-purpose gases, gas mixtures and
ppm HiQ calibration gas mixes, many of
associated products that comply with very
which are manufactured at Afrox’s state
high purity and quality standards.
of the art gas operations centre (GOC)
Afrox HiQ speciality gases include pure
A gas chromatography-mass spectrometry instrument, which is used in a laboratory or testing facility
facility located in Germiston, South Africa,
scientific gases, made-to-order scientific
offer customers legislative compliance,
carrier gases and mixtures and calibration
consistency, accuracy and cost savings.
mixtures for certifying the accuracy of instruments. They also cover a host of special purpose mixtures for safety, R&D at scientific laboratories and health facilities and are used in the petrochemical, energy and mining industries. Argon, carbon dioxide, helium, nitrogen and oxygen are the high purity atmospheric gases that feature at the starting point of the HiQ product range. For use in HiQ gas formulations, each of the source gases must be of exceptionally high purity. ‘We talk about gas purity levels
Afrox HiQ gases are widely used as carrier gases for gas chromatographymass spectrometry instruments
in terms of a number of nines. A five nines
In the petrochemical industry, samples of a fraction from the distillation of crude oil, such as diesel, petrol or natural gas, are analysed. The chosen fraction gets vapourised and separated on a chromatography column. It then goes into
(N5) purity for example is 99.999 percent
In addition to the calibration gases
the mass spectrometer, which produces a
pure, which means it has an impurity level
for environmental and safety monitors,
of less than 0.001 percent or 10 parts per
chromatogram from which every constituent
Afrox HiQ gases are widely used as carrier
million,’ Strydom explains.
element of the sample, including all of the
gases for gas chromatography-mass
impurities, can be identified and quantified.
For modern HiQ gases, Afrox now offers
spectrometry (GC-MS) instruments. These
The result is automatically compared
six nines (N6) purity levels, which contain
are used in laboratories and testing facilities
less than 1.0 ppm of contamination. This is
to a database of substances, so all the
to determine the exact constituents and
the basis for the HiQ 60 range. These gas
constituents and their percentages are
contamination levels of substances.
immediately identified. If the instrument is
mixtures are designed to have a shelf life of up to 60 months, as opposed
Applications include drug detection, environmental analysis, fire
calibrated for a particular substance mix, then tiny quantities of the contaminant of
to previous generation mixtures
and explosion
that could only be guaranteed
interest can be found. In this instance, Afrox
investigations and the
for 36 months.
is currently working on a very toxic benzene/
identification of unknown
toluene/xylene calibration gas.
substance samples.
‘We thrive in situations where researchers
Why calibration is critical
HiQ helium for GC-MS
When it comes to the
for African conditions, for dealing with
instruments. While the purity
calibration of safety critical
mosquitoes and malaria, for example,
of the carrier gas is crucial
measuring equipment, the
as well as for a host of biochemical and
to the accuracy of the result,
purity level of the calibration
health applications, such as IVF treatment,’
the instruments themselves
mix represents true value.
Strydom reveals. •
are also very sensitive to
The company offers
To calibrate these instruments, the calibration
oxygen, moisture and any Hans Strydom
hydrocarbon contaminants.
are looking for solutions tailor made
Afrox – www.afrox.co.za
P C Review | JULY 2018 |
21
SUN CARE
Stop skin ageing,
safely and effectively Micah from Hallstar is a revolutionary and safe way to stop the ageing process in its tracks. It’s neither a filter nor an antioxidant but a new chemistry based on fused-ring cyanoacrylates, offering a novel path to skin protection.
P
roducts aimed at the prevention of
toxicity, placing yet another obstacle in the path
ageing have progressed at a fast
to create advanced anti-ageing sun protection
pace. Innovative stabilisation
products. With its breakthrough Micah
chemistry has enabled
authentic, effective protection from direct damage by the most penetrating, longer wavelength
Free-radical damage is the leading cause of premature ageing and a primary skin care concern worldwide
(340 and 400nm) UVA-I rays. However, even some stable chemical sunscreen agents are capable of transferring
DID YOU KNOW?
chemistry, Hallstar, represented in South Africa by Millchem, offers a solution to these challenges which
stops the photo-ageing process Micah is a great example of Hallstar’s world-class capabilities. before it starts. The Micah chemistry received a Silver award in the functional category Innovative technology during the 2017 in-cosmetics Unlike sunscreens or antioxidants, Global Innovation Zone Best independent clinical research shows Ingredient Awards.
the energy they absorb into molecular oxygen and causing
a mere 0.2 percent of Micah in a skin care product prevents 100 percent of free
damage to the skin’s DNA, protein and
radicals, ROS, inflammation and DNA damage
lipids. Antioxidants are often added to sun
from UVA and visible light.
care products to scavenge and quench
Micah has been proven to eliminate one of
resulting free radicals and oxidation, yet
the key causes of UV-related ageing by stopping
their neutralisation capability is limited
the formation of damaging light-induced ROS
and complicated by their strong colour,
and free radicals. By acting directly on skin’s
even at low concentrations.
photosensitisers, such as the endogenous
Even with highly advanced formulations
poryphyrins, the chemistry stabilises and
and ideal usage, the effects of the UVA-I region
balances energy conditions within the skin, with
of the light spectrum can never be completely
the potential to stabilise skin’s own retinol.
blocked or absorbed. UV photons will always take
The fused-ring cyanoacrylates quench the
some kind of toll on the skin whenever exposure
excited photosensitisers by accepting the
occurs. This is coupled with consumers’ concerns
energy transfer. The quenching then returns the
about synthetic ingredients and their perceived
photosensitiser to its original state, eliminating
• Contract manufacture of bath/body/beauty/anti-ageing products • We have no brands of our own and therefore do not compete with our customers • Offer a turnkey operation from concept to launch of all products • Formulation development for local and international markets • Perform stability/micro testing for all products • Source new packaging locally and internationally • Sun protection
Tel: +27 (0)12 803 7999/+27 (0)12 803 0761/+27 (0)83 285 8830 Email: andre@serendipitytoiletries.com/ madelein@serendipitytoiletries.com | www.serendipitytoiletries.co.za
Serendipity.indd 1
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SUN CARE the possibility for a singlet oxygen molecule and
were treated with four different Micah dosages
subsequent ROS and free radicals to be generated.
from 0.02 to 0.20 percent and exposed to UVA
Despite its advanced mode of activity, Micah does
irradiation between 320 to 400nm. The results
not result in any structural or functional changes
showed 0.20 percent Micah effectively prevented
within the extracellular matrix.
UVA-induced ROS and was even more effective than two percent tocopherol.
A first for SA
Because free-radical damage is the leading
Driven to innovate, Nimue Skin Technology is the first
cause of premature ageing and a primary skin care
skin care brand in the world to launch a product
concern worldwide, Hallstar’s Micah presented the
formulated with Hallstar’s Micah (Polycyclic Diester).
right technology and consumer perceivable benefits
The South African specialist in derma-cosmeceutical
for Nimue’s latest sun care innovation.
skin care says its Environmental Shield SPF50 ‘is the
Independent clinical test results show Nimue’s
most advanced SPF ever’. This is because it offers
Environmental Shield SPF50 ‘presents a good photo
high protection against the full electromagnetic
protective activity against IR and UV light’, ‘a good
light spectrum, including UVA and UVB rays and HEV,
protection against the increase of skin colour
also known as blue light. A lightweight texture and
induced by blue light irradiation’ and ‘a good
non-whitening finish are additional product claims
activity against modifications induced by the mix of
and because of its mattifying effect, Environmental
pollutants on human living skin explants’. The results
Shield SPF50 is ideal for oily and problematic skins.
also concluded it ‘totally inhibits an increase in the Nrf2 inflammatory pathway induced by the mix of
Proven results
pollutants’ and ‘totally inhibits lipid peroxidation
To understand the impact of Micah on UVA-
induced by the mix of pollutants’. These findings
induced ROS, inflammatory cytokines and DNA
prove Nimue’s Environmental Shield SPF50 is a good
damage, Hallstar commissioned an independent
product to protect against pollution. •
study at the Dead Sea & Arava Science Centre at Israel’s Ben Gurion University. Ex vivo human skin explants (0.64cm2) harvested from female patients who had undergone abdominal surgery
Hallstar – www.hallstar.com Millchem – www.millchem.co.za
P C Review | JULY 2018 |
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SUN CARE
A natural alternative for sunscreens
Calcium hydroxyapatite, a mineral commonly found in our bodies, is an ideal alternative to UV filters that could cause skin irritations. Through extensive R&D using this mineral, Kalichem has produced a physical filter called Apalight, which also improves the performance of sunscreens. skin friendly filter
about 18 percent and the SPF50 around
helps formulators
two percent.
develop products
Along with its comparable sunscreen
with enhanced
efficacy to micronised TiO 2, Apalight offers
sun protection.
the interesting advantage of complete physiological compatibility. The ions are
Increased SPF
slowly incorporated into skin’s structure,
Although TiO 2 is
leaving skin’s surface free from solid
one of the most
residues in the long run.
widely used UV filters
C
in sun protection
Turn back time
products, it can easily
Apalight is perfect for use in an anti-
be replaced with
ageing day cream that offers added
Apalight. Kalichem
sun protection. Several in vivo tests were
determined this
done to prove its anti-ageing benefits.
through in vivo SPF
A sensory evaluation revealed Apalight
alcium hydroxyapatite is
tests on two sets of three formulations,
provides a statistically significant soft
essential for our physical
one with Apalight and the other, TiO 2.
focus effect with six out of 10 volunteers
and mental well-being.
The formulations included the Colipa
noting a decrease in fine lines and three
This nutritious element
Standard P3 and SPF30 and SPF50
out of 10 noting a decrease in deep
W/O emulsions.
wrinkle volume. Cutometer measurements
found for instance in bones and teeth, is important in the maintenance of all
Six percent Apalight was included in
revealed an increase in skin’s elasticity and a decrease in the visco-elastic ratio.
physiological processes and strengthens
the Colipa Standard P3, four percent in
bone structure by catalysing several
the SPF30 and five percent in the SPF50.
Kalichem’s products and innovative
biochemical reactions.
Respective quantities of TiO 2 were used
technologies for the personal care and
in the second set of formulations. In
cosmetics industry are available in South
significance in the sun care category.
all cases, the evaluations showed an
Africa from Orkila. •
Kalichem’s calcium hydroxyapatite
increase in the SPF values, with Apalight
innovation, Apalight provides a physical
being notably higher TiO 2. The SPF
alternative to chemical sunscreen filters.
in the Colipa Standard increased by
As a micro-dispersed, solid active, this
approximately nine percent, the SPF30 by
It’s also been found to be of
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| JULY 2018 | P C Review
Kalichem – www.kalichem.it Orkila – www.orkila.com
SUN CARE
More than routine protection
is needed for sun care in Africa ‘Favourable colour, good complexion’ – Motshidisi Thoko, 31
‘A perfect skin is smooth, even toned with no dark spots, no pimples, not flakey and no enlarged pores’ – Thando Zuma, 25
‘No black spots, no blemishes; don’t want to have to cover up with makeup’ – Zinzi, 29
The concept of sun care is uncommon among black consumers, yet they demand an even skin tone. Croda reveals insight into the sun care category and the solutions available to formulators to overcome a variety of challenges when producing sunscreens.
C
aggravates melanin production and causes further dark spots. Acne scars are also more susceptible to the sun, further emphasising the need for a sun care product.
Inorganic sunscreens roda South Africa conducted a recent
Formulated with mineral UV filters, such as titanium
consumer study where 72 black South
dioxide (TiO2) and zinc oxide (Z nO), inorganic
African women were interviewed.
sunscreens have long been regarded as safe
Results show 79 percent recognised
and effective.1 They are preferred by individuals
the need for sunscreen to prevent their skin from
with a high propensity for skin irritation instead of
becoming darker. It was also evident most of the
sunscreens containing organic UV filters. Recent
women did not understand the effects of sun on
studies on the environmental impact of sunscreen
black skin.
actives have seen inorganics favoured by consumers
Whilst black skin does not necessarily ‘burn’ due
seeking marine-safe sunscreens. In the US, Hawaii
‘Flawless, no marks’
to its high levels of melanin, other negative effects
became the first state to pass a bill banning the
can occur. These include short term effects like pain,
sale of sunscreens containing organic UV filters
tightness and sensitivity, to longer term adverse
Benzophenone-3 and Octyl Methoxycinnamate,
– Boitumelo Molapo, 26
effects as shown in Table 1. Darkening of the skin
which are believed to harm coral reefs.2
caused by UVA can lead to hyperpigmentation, which results in dark patches and uneven skin tone.
‘Bright and glowing’ – Moipone, 26
The desire for an even skin tone was evident in the women’s responses in the consumer study. The strong desire for an even skin tone is further complicated as African skin is generally quite oily. Excessive sebum can lead to acne, which
Organic or ‘chemical’ sunscreens, such as Butyl Methoxydibenzoylmethane and Benzophenone-3, absorb high intensity UV rays, whereas inorganic or ‘physical’ sunscreens, attenuate UV by three mechanisms: absorption; reflection and scattering. Because of these different mechanisms, inorganic sunscreens attenuate UV over a broader wavelength range, which is one of
Table 1
‘My skin should glow’
Region
UVB
Wavelength Range (nm)
280 to 320
– Thembi Baloyi, 45
HEV (Near-UV)
320 to 400
380 to 500
– Ellen More, 48
Epidermis to basal cell
Dermis
Dermis to blood cells
• reddening • blistering • pain/sensitivity • skin cancer
• tanning/darkening of skin • f ree radical formation • s kin ageing • vascular and lymphatic damage • DNA damage
• degrades elastin and collagen • f ormation of glycation wrinkles •p remature ageing
A summary of how UV light can be categorised according to wavelength and the corresponding potential damaging effects on skin
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| JULY 2018 | P C Review
of these materials. Despite these traditional inorganic
Increasing penetration
Damage caused to skin
the many advantages
benefits, the use of
Decreasing energy Penetration
‘Velvet like, smooth and no pigmentation’
UVA
UV filters was limited because of poor aesthetics – the large particle sizes of TiO2 and Z nO left a white film on the skin. To overcome these limitations, patented
SUN CARE 70
sun care technologies
UVB
have been
Visible
UVA
60
developed. Croda, a leader in inorganic sunscreen
50
dispersions, has a wealth of
Attenuation
expertise in sun care and was the first supplier to develop and market TiO 2 dispersion technology. This
40
30
20
technology improved product performance, enhanced product stability and promoted ease of use.
10
Solaveil Clarus was the breakthrough in terms of product aesthetics offering true
0 290 310 330 350 370 390 410 430 450 470 490 510 530 550
transparency on skin, comparable to an organic sunscreen. Ensuring the aesthetic performance
Wavelength (nm)
of Solaveil Clarus on black skin has been a key objective of Croda’s Technical Centre of Excellence in Africa. Studies have been undertaken which show
In terms of their UV performance, the absorption
Solaveil Clarus did not lead to ‘ashing’ or whitening
profiles of TiO 2 and Z nO are largely dependent on
on black skin. The study compared a conventional
the particle size of the metal oxides. SPF varies
TiO2 suspension to a Solaveil Clarus TiO2 dispersion,
significantly if sunscreen formulations are made
as well as finished formulations with an SPF15.
with the same concentration of inorganic particles
Figure 2 shows just how transparent the formulation
and if the sizes of the particles in the formulation
containing Solaveil Clarus (D) is on dark skin.
vary. In contrast, the UV absorption profiles of
Figure 1: UV visible attenuation versus wavelength for titanium dioxide of varying particle size. Blue line, 20nm; green line, 50nm; and red line, 100nm
High-performing UVA Filter
TC-UV TDSA TINCI is proud to announce the launch of a new water soluble, photostable UVA filter called Terephthalylidene Dicamphor Sulfonic Acid. The product is a broad-spectrum sunscreen which offer a fresh skin feel. The product has excellent compatibility in formulations, is colorless and safe. Dosage recommendations will range from 0,5% - 5.0% and can be used in lotions, sprays and creams.
UV Feature UV Feature 600
UVA
UVB
500
E(1%/cm)
400
300
• λmax
345nm ( aq)
• λc (critical wavelength)
373nm ( aq)
• UVA/UVB
200
• E(1%,1cm)
1.29 513(345nm)
100
0 300
320
340
360
380
400
Wavelength/cm
Tel: +27 (0)11-965-1508 Email: Clive Gouws – clive@acaciachem.com www.acaciachem.com
Acacia Chemicals.indd 1
2018/05/15 8:25 AM
P C Review | JULY 2018 |
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SUN CARE requires sun protection products sold in America meet this critical wavelength. 4 Asia meanwhile uses an in vivo persistent pigment darkening (PPD) method to assign a PA label to a product, based on its UVAPF.
Formulation approaches Sunscreen formulators also face challenges in terms of which approved UV filters to use. There are a number of approaches to overcome this, such as using organic or chemical, UVA and UVB filters to provide high SPF broad spectrum protection. Yet this type of system cannot be labelled ‘natural’. Chemicals and the perception that these sunscreens can Figure 2: Comparison between a conventional TiO2 neat suspension (A), Solaveil Clarus neat dispersion (B), conventional TiO2 SPF15 formulation (C) and Solaveil Clarus SPF15 Formulation (D) on dark skin, using 10 rub-outs
organic UV filters are more closely related
lead to skin irritation, or are harmful to marine
to the concentration of the filters. Figure 1
life, present limitations in the market. The
shows the UV-visible properties of TiO 2 for three
regulatory limits on the quantity of organic
Sunscreen claims Cosmetics industry regulatory classed as effective and sufficient protection against both UVA and UVB radiation. Yet creating
The simplest option from a regulatory point of view is to use inorganic actives only
globally approved UV protection products can be a challenge, since
requirements differ from one continent
is to select a range of organic and inorganic UV filters. However, incompatibilities between ingredients and the global IP status of some UV filter combinations can complicate the
The final and simplest option from a regulatory point of view is to use inorganic
to the next.
actives only. Formulations based on these
In Europe, the European Commission recommends the
actives ensure a ‘natural’, mild and safe
UVA Protection Factor (UVAPF) of a
product can be produced, although care
sunscreen should be at least one
is required to ensure the aesthetics appeal
third of the labelled SPF. The critical
to consumers.
3
A high SPF and a high degree of sensory
wavelength of the product should be at least 370nm. These regulatory
elegance can be achieved when Solaveil
requirements have been harmonised
Clarus TiO 2 is combined with Solaveil Clarus
in Australia. For the US, the FDA
Z nO. The formulation in Table 2 is a Skin
3
Crodamol DA (Diisopropyl Adipate)
Protecting UV Fluid SPF50. Inspired by trends in Asia, this anhydrous system is an unusual Functionality
% w/w
Light emollient
31.00
Crodamol GTCC (Caprylic/Capric Triglyceride) Light emollient
6.40
Silsoft 034 (Caprylyl Methicone)
Silicone emollient
5.50
Crodamol EO (Ethyl Oleate)
Light emollient
2.50
Cromollient DP3A (Di-PPG-3 Myristyl Ether Adipate)
Rich emollient
1.80
Span 120 (Sorbitan Isostearate)
Dispersing agent
1.80
B
Aerosil R 972 (Silica Dimethyl Silylate)
Bodying agent
3.50
C
Solaveil CZ-100 (Zinc Oxide (and) C12-15 Alkyl Benzoate (and) Polyhydroxystearic Acid (and) Isostearic Acid)
Inorganic UVA filter
40.00
Solaveil CT-100 (C12-15 Alkyl Benzoate (and) Titanium Dioxide (and) Aluminium Stearate (and) Polyhydroxystearic Acid (and) Alumina)
Inorganic UVB filter
4.50
Renovage (Caprylic/Capric Triglyceride (and) Teprenone)2
Anti-ageing active
3.00
alternative to a traditional emulsion. This ultra-low viscosity fluid combines Solaveil CT-100 and Solaveil CZ-100 to produce a mineral sunscreen that meets global regulatory requirements. •
Croda – www.crodapersonalcare.com REFERENCES: 1. N ohynek GJ, Dufour EK, Arch. Toxicol. 86(7):1063-1075, 2012 2. https://www.nytimes.com/2018/05/03/travel/hawaii-sunscreenban.html
A novel approach to incorporating Z nO and TiO 2 in a formulation, which offers high SPF and broad spectrum skin protection
| JULY 2018 | P C Review
especially for high SPF claims,
formulation process.
UVA protection and labelling
Phase Ingredient/INCI Name
28
Another common solution used by global formulators,
In South Africa, the sun care category witnessed some cannibalisation and loss of sales from skin care and colour cosmetics that offer higher SPF.
Table 2: Skin Protecting UV Fluid SPF50
D
difficult to achieve high SPF claims.
DID YOU KNOW?
requirements dictate what is
A
sunscreens permitted for use also make it
different aggregate sizes.
3. European Commission Recommendation of 22 September 2006, on the efficacy of sunscreen products and the claims made relating thereto; Official Journal of the European Union, p L 265/39L265/43, 26 (Sep 2006) 4. F ood and Drug Administration, Final rule: Labelling and Effectiveness Testing; Sunscreen Drug Products for Over-theCounter Human Use, Federal Register, Vol. 76, No. 117 (June 2011)
SUN CARE
How to
better protect millennials
DSM is targeting millennials as an untapped consumer group in the sun care category. Its South African agent, Chempure shares insight into this strategy, based on the results of a recent sun survey of various consumer groups.
T
he global producer of personal care ingredients and nutritional
portfolio of sun care ingredients. Two examples are the No Fomo sun stick SPF50 that blurs pores and imperfections and a UV Flash Tone Fluid SPF30. The opaque sun stick helps the user protect all areas of the face, including the eye, mouth and nose areas. Its fun format fulfils millennials’ aspiration for packaging allowing total flexibility for reapplication. The UV Flash Tone Fluid is a transparent yet corrective face product that plays with light to provide a glass skin effect. This is perceived by millennials as a smooth, flawless, pore-less skin with a beautiful, almost ethereal sheen. UVB and UVA protection across the full
products conducted a consumer
Break protection boundaries
proprietary sun survey on 5 600
A key ingredient in both these formulations
concentration. It demonstrates excellent
consumers from various global locations.
is Parsol Shield. This photostable broad
compatibility with organic and inorganic
A total of 1 172 respondents were
spectrum filter from DSM efficiently boosts
UV filters and is readily compatible with
range of applications and is used at a low
millennials, which revealed 83 percent of
other Parsol products, in particular
them use more sun protection that other
Parsol 1789.
consumer groups surveyed (74 percent). However, only 23 percent of millennials reapply sunscreen throughout the day and only 15 percent apply sunscreen to
BARRIERS TO ALL ROUND USAGE
Parsol Shield, available in South Africa from Chempure, delivers outstanding performance that breaks through the boundaries of UVB and UVA exposure to continue into the blue light spectrum to
their back and torso when at the beach.
protect skin.
Most millennials also only consider sun
RESULTS FROM DSM’S sun survey show the
protection necessary on sunny days and
following factors hinder thorough use of sun
during summer/warm months. However,
care products:
Shield supports high levels of water
year-round sun protection is essential for
1. R espondents haven’t been to places where
resistance due to its good solubility in
all consumer groups. To overcome these barriers and
it’s sunny enough 2. T hey found it hasn’t been sunny this year
encourage more millennials to use sun
3. They covered up instead
care products consistently throughout
4. Sun care products are too oily or greasy
the year, DSM developed a range of
5. I ts inconvenient to carry around a sunscreen.
innovative formulations using its Parsol
As part of a holistic formulation, Parsol
organic oils. It also meets the highest standards for safety and quality. •
Chempure – www.chempure.co.za DSM – www.dsm.com
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SUN CARE
Increase SPF efficiency and enable better aesthetics Dow Home & Personal Care’s senior scientist, Kinjal Joshi and global strategic marketer for skin and baby care, Jon Fedders discuss the benefits of a new polymer technology for sunscreen and SPFenabled skin care products.
T
he sun and skin care categories are trend driven and meet consumers’ needs from Durban and Denver to Dublin, Delhi and beyond. According to Mintel GNDP, since
2009 until now UV protection has been the number one product claim among global foundation and sun care brands.1 SPF claims have been trending upward for many years, which is reflected in the steady growth of the sun care market. This growth can be partially attributed to rising awareness that UV exposure causes premature ageing and is associated with heightened health risks. Concerns about the increased risk of skin cancer have placed an even greater focus on the SPF performance of skin and sun care products. Consumers expect higher SPF claims from their sun and skin care products with reliable, even skin coverage, plus water and rub-off resistance to ensure these benefits are locked in place. Yet, incorporating a higher SPF into a formulation can easily compromise a product’s aesthetic properties. For sun care products to remain competitive, they can no longer have a white film or tacky, greasy finish. The key to providing consumers with the best of both worlds is to tap into the benefits of new polymer technologies.
Balance SPF with aesthetics Micronised titanium dioxide (TiO2) is widely used as an inorganic UV absorber to formulate high SPF
Sun care products that leave a white film or greasy finish on skin are losing consumer appeal over those with appealing sensory benefits
sunscreens. Yet it tends to flocculate partially, either in the formulation or on skin, to the extent that its UV filter efficiency is reduced. This causes undesirable skin whitening, which compromises the user’s sensory experience. Soltex INO polymer was developed by Dow to boost the efficiency of inorganic UV absorbers for sun and skin care applications. This innovative material provides a new approach to enhance the performance of inorganic based sunscreens, including TiO2, zinc oxide (ZnO) and other iron oxides. It is a functionalised acrylic polymer designed as an additive to sunscreen formulations made with TiO2 powders or dispersions. It allows formulators to access various coated TiO2 filters in their formulation basket and to rapidly create new products that balance consumer demand for high SPF performance with desirable sensory benefits.
How it works Soltex INO polymer is designed to increase the spacing between clusters of TiO2 particles in the sunscreen once dry on the skin surface, which
Figure 1: SEM imagery of a TiO2 dispersion without (left) and without (right) Soltex INO polymer
minimises flocculation. It works by attaching to the TiO2 molecule surface, which provides and maintains more uniform spacing among the TiO2 particles. This increases SPF performance by improving the overall dispersion of inorganic particles – including TiO2 and ZnO – in the formulation. Figure 1 shows SEM images of how Soltex INO polymer improves the dispersion of TiO2 in a sunscreen formulation in comparison to a control. The improvement of the inorganic particulate dispersion is dependent on the formulation type, the TiO2 particle size and its surface treatment. However, Soltex INO polymer boosts SPF consistently well across different types of TiO2. In all cases, skin whitening and unevenness caused by agglomerated TiO2 particles are suppressed for sunscreen formulations containing
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| JULY 2018 | P C Review
SUN CARE the new functionalised
Figure 2: In vivo test results for the O/W emulsion with TiO2 sunscreen prototype
acrylic polymer versus TiO2 alone. The polymer significantly improves sensory performance by reducing the amount of TiO2 needed to achieve the targeted SPF. Compatible with multiple formulation types and grades of TiO2, the polymer also improves ZnO dispersion for better UVA coverage.
Performance tested
Many additional in vivo SPF studies
Numerous in vivo SPF studies were conducted on inorganic oil in water
DID YOU KNOW?
(O/W) and water in oil (W/O) emulsion sunscreens with various grades of hydrophobically coated TiO2 powders with different surface treatments. The formulations were prepared with TiO2 and Soltex INO polymer versus the equivalent dosage of TiO2 alone. The in vivo SPF results were measured via Static SPF FDA 2011
of formulations. Results indicate the polymer is compatible with
multiple formulation types Synthetic polymers with multiple and grades of TiO2 and it functions and benefits, such as film formers for better UV and pollution improves ZnO dispersion protection and water and sand resistance, for better UVA coverage. are expected to grow by 1 000t in the Soltex INO polymer global sun protection market between overcomes the shortfalls 2015 and 2020. Source: Evolving Trends of standalone TiO2 and ZnO and Hottest Ingredients in Sun formulations by reducing Protection posted on blog. euromonitor.com particle agglomeration to create a more even, long lasting particle
technique on seven subjects. The polymer nearly doubled SPF performance in O/W emulsion formulations (see Figure 2). Achieving the same level of SPF performance in this formulation required slightly more than double the amount of TiO2. In vivo SPF studies were also conducted on inorganic-based O/W emulsion sunscreens using ZnO as the SPF ingredient. Results of this formula clearly indicate Soltex INO polymer provides a significant SPF boost to ZnO formulations with only a slight impact on sensory aesthetics (see Figure 3).
were conducted on a wide range
distribution on skin. This new polymer technology delivers long lasting, even coverage and enables the use of less mineral based material to achieve an
Soltex INO polymer boosts SPF consistently well across different types of TiO2
equivalent or better SPF protection. Soltex INO polymer also helps skin and sun care brand owners meet consumer demand for aesthetically pleasing sun and skin care products that deliver high SPF protection. •
Dow Home & Personal Care – www.consumer.dow.com
Stability Testing Services, a division of Botanichem, offers a well equipped onsite laboratory for independent stability testing for the cosmetic industry. Stability testing is vital to ensure your product maintains its intended physical, chemical & microbiological quality. We offer: • Stability Testing • Regulatory Labelling • Formulation • Product Information Files for Export FOR MORE INFORMATION CONTACT ROBYN OR LINA. 011 425 2206 OR 011 425 2648 info@botanichem.co.za / lina@botanichem.co.za
P C Review | JULY 2018 |
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SUN CARE
Prepare skin for
life in the light
While UV radiation is known as a primary aggressor of skin damage and premature ageing, blue light is just as harmful. Because it’s almost impossible to escape the sun and electronic devices, Lipotec has come to consumers’ rescue with Lumicease blue ingredient to repair damage induced by solar and artificial blue light.
O
verexposure to the sun is believed
Opsins detected in human skin are the main
to cause up to 90 percent of the
photoreceptors of the eye and play a significant role
signs of skin ageing such as wrinkles,
in light perception. They are believed to help skin act
roughness, sagginess, skin thickening
as a sensory system for light, increasing its alertness
and dark spots. The sun also emits infrared (IR) and
and protection. Humans and animals’ ability to adapt
blue light, which are more harmful than UV rays and
was a key focal point for Lipotec’s development team,
penetrate deeper into the dermis. Blue light can
which set out to produce an active ingredient that
also be found indoors, since it is artificially produced
could effectively mimic this process.
by electronic devices such as computers, TVs,
Giving back to Mother Nature
smartphones and tablets. Unfortunately, regular
Tucked away in a waterfall in the Eastern Pyrenees,
sunscreens do not provide
in Northern Spain, the team found its answer in a
protection against blue light and
microorganism that is highly resistant to radiation.
IR. So, smartphone dependency,
Exiguobacterium was isolated in line with Lubrizol’s
Lipotec has taken its commitment
the selfie boom and extended
sustainability policy, which prevents large amounts
to preserving the environment a
periods spent in front of computer
of materials being harvested from nature and
step further, by pledging to donate a
screens can negatively impact
ensures sustainable practices are maintained
percentage of the sales of Lumicease
skin’s appearance.
throughout the process.
blue ingredient to Paisatges Vius,
To protect itself from light-
Using biotechnology, Lumicease blue ingredient
a non-profit organisation. Based in
induced damage, human skin
was developed to protect and repair skin, ultimately
Northern Spain, the organisation is
adapts by developing biological
minimising the main signs of photoageing.
dedicated to conserving the aquatic
mechanisms that increase its
The ingredient activates opsins on the skin and
ecosystem of the Pyrenean area
resistance to light. This occurs
promotes adaptive responses, which help prepare
where the isolation of the microorganism
in the same way animals
skin for future exposure to light.
took place.
camouflage themselves to adapt to an environment.
32
Sustainability first
| JULY 2018 | P C Review
In vitro test results show that, in addition to activating opsins – which are considered as the eyes
SUN CARE of the skin – Lumicease blue ingredient helps induce
a 13.2 percent reduction in average roughness
skin’s adaptive responses against light damage.
observed after 56 days of treatment.
An increase of cell survival and improvement
Lipotec’s Lumicease blue ingredient, available
and protection of the extracellular matrix were
in South Africa from Savannah Fine Chemicals,
also observed.
prepares, protects and repairs the skin from solar and artificial blue light. These mechanisms of
Effective in skin repair
action help minimise the main signs of digital and
A clinical test was performed on women who
photoageing so consumers can enjoy their lives in
applied a cream with two percent Lumicease blue
the light. •
ingredient on half of their face and a placebo cream on the other. The test took place during the
Lipotec – www.lipotec.com Savannah Fine Chemicals – www.savannah.co.za
summer and the women were exposed daily to artificial blue light. At the end of the study, the number of brown
Lumicease blue ingredient helps induce skin’s adaptive responses against light damage
spots decreased by 11.7 percent. The amount of UV spots, which
Figure 1: Lumicease blue ingredient has a protective effect against the appearance of future brown spots. Changes in the UV spots were assessed by the Visia complexion analysis system
were not yet visible, were also reduced by 14.1 percent (see Figure 1). These positive results suggest Lumicease blue ingredient is effective in skin repair. Its anti-ageing benefits were proven too with a
0 Days
in wrinkle volume and
MAXIMUM SUN PROTECTION WITHOUT STICKY SKIN. WHY NOT? Building sand castles or splashing around in the sea: children love everything about the beach – except for those annoying breaks to put on more sun cream and the sticky hands and itchy skin that may go with it. Fortunately, our water based film former Baycusan® C1004 allows for very waterresistant emulsions with a sand resistance effect. It combines safe and easy application with no sticky skin and outstanding long-term protection – for the delicate skin of children who like enjoying the sunshine, sand and sea all day long.
56 Days
Covestro Deutschland AG, D-51365 Leverkusen · COV00084965
21.5 percent reduction
Beauty Made Possible.
Y) LTD CHEMICALS (PT h.co.za SAVANNAH FINE .za | www.savanna info@savannah.co
Distributed by
baycusan.com COV00084965_Baycusan_Kids_130x177mm_0618.indd 1
26.06.18 15:24
P C Review | JULY 2018 |
33
PRESERVATIVES
Consider CPC as an alternative from Vertellus looks at the changing regulatory landscape and how consumer preferences cast a spotlight on the need for alternative preservatives. Jessica Byrd
I
of respondents were hesitant to purchase personal care items when confused about the ingredients1. A total of 51 percent said they would be willing to switch to another brand if they better understood the ingredients in the product and 48 percent said they would be willing to pay more for a personal care
ngredient manufacturers can tell a lot about the issues on formulators’ minds through
product formulated with recognisable ingredients. Today’s consumers also pay more attention to
engagement at industry trade shows. Concerns
their environmental footprint. Eventually, personal
about ingredients in personal care products
care products and cosmetics get washed off and
was a significant topic of discussion at in-cosmetics
end up in the water supply. In today’s eco-conscious
Global in Amsterdam. Much of the conversation
world, there is growing recognition that consumers
focused on the safety, efficacy and environmental
should be more aware of the environmental impact
profile of these ingredients and whether there are
of the products they use.
alternatives available to address regulatory and consumer concerns.
The MIT ban Ingredients used in deodorants, shampoos and cosmetics are coming under global scrutiny from regulatory bodies. In 2016, the European Commission (EC) banned the use of
There is also the issue of resistance. The longer a preservative is used, the greater its potential to
TRUSTED PERFORMANCE ATTRIBUTES
methylisothiazsolinone (MIT) as an ingredient in leave-on products. The EC ban of MIT followed
APART FROM THE consumer appeal of CPC, the ingredient
public consultation on the substance, organised
has a trusted history. CPC has been used for more than 40
subsequent to a 2013 assessment by the
years as a US FDA-approved anti-gingivitis ingredient in oral
Commission’s Scientific Committee on Consumer
health products.
Safety (SCCS). The SCCS assessment concluded
The legacy of trust in the oral care category and unique
the use of MIT in leave-on products was unsafe
performance attributes of CPC make it attractive for new
due to its sensitising potential. Used as a
formulation applications in the personal care space. Some
preservative in products such as body lotions,
of its key performance benefits include:
cosmetics and deodorant, MIT has been linked to
• a strong efficacy against a wide range of gram positive
an increasing number of allergy incidences. Consumer surveys also show increased
and gram negative bacteria and fungi • its ability to effectively reduce odour-causing
awareness in the safety of
bacteria, making it suitable for a wide variety of
ingredients. The 2017 Label Insight Ingredient Confusion Stud1
deodorant applications • it is biodegradable and does not persist in
conducted among American
the environment.
consumers found 31 percent
The main challenge of mild, “Free Of” preservatives is microbial contamination. Sharon is offering a new preservative solution, with amplified efficacy. The range offers broad spectrum, superior activity, allowing a significantly lower level of use in finished product.
less preservative delivers more protection. +27 11 494 6700 | info@cjpchemicals.co.za | www.cjpchemicals.co.za CJP Chemicals.indd 1
34
| JULY 2018 | P C Review
2018/06/29 2:37 PM
PRESERVATIVES become ineffective against microorganisms
in the personal care space for more than four
like bacteria, which adapt to the preservative
decades. CPC is approved for use in personal
ingredient. With this in mind, formulators like to
care preservation in Japan and European
mix up their preservative options to stay ahead
authorities are currently reviewing CPC for
of resistance.
Annex V approval.
Whether ingredient concerns stem from
In response to the increased demand from
regulatory bodies or consumers, the
regulatory bodies and consumers for
message for formulators and personal ingredients used in personal care products are under scrutiny.
A trusted solution with CPC Faced with this dilemma, one approach might be to identify a ‘silver
alternative preservatives in body washes
DID YOU KNOW?
care manufacturers is clear:
and other personal care products, Vertellus identified CPC as a
Freshstat is an excellent replacement for triclosan, triclocarban, MIT, benzethonium chloride, formaldehyde-donors and parabens in leave on and rinse off products.
bullet’ – a solution that delivers safety,
logical solution. The Freshstat and Freshstat Plus blends are specifically formulated to help formulators address the safety, efficacy and environmental concerns of regulators and consumers.
Free of parabens, phthalates,
efficacy, reduced environmental impact and
isothiazolinone and formaldehyde,
Good for your formulations
cost-effectiveness. To overcome the challenge,
Freshstat and Freshstat Plus provide
global manufacturer of fine and speciality
a broad spectrum of efficacy against
The Freshstat family of
chemicals, Vertellus focused on cetylpyridinium
bacteria, yeast and mould.
products are effective at very low concentrations and can
chloride (CPC) to develop the Freshstat family with several attributes that address the needs of
Cationic and anionic formulations
personal care formulators.
Even the most attractive preservative
and Freshstat Plus are also
won’t be effective if it is not compatible
compatible with a wide
to personal care, CPC is not new in the chemical
with a formulation’s system. Because
variety of raw materials.
industry. Vertellus has been working with CPC
anionic systems contain a high
of preservatives. CPC is a long-trusted chemical
Although the Freshstat family is relatively new
Better together with
be formulated to work across a broad pH range. Freshstat
Personal Care
Our task is to help unveil beauty
PRESERVATIVES: Below is a selection of a wide range products for preservation and also some for natural antimicrobial solutions that we offer. AMTicide® Coconut From fermenting coconut fruit with Lactobacillus to deliver a non-irritating, anti-fungal and effective multifunctional product Leucidal® Liquid SF From the fermentation of Lactobacillus in a defined growth medium, this yields a unique peptide and broad spectrum, antimicrobial and conditioning properties. This ferment filtrate is salysalicylate free Leucidal® Liquid PT Fermented from Lactobacillus acidophilus in the presence of sustainable castor oil. Has enhanced antifungal activity. The result is a broad spectrum antimicrobial product with probiotic and conditioning properties.
KATHON™ CG Preservative • An aqueous mixture of methylchloroisothiazolinone and methylisothiazolinone primarily used in rinse-off products such as shampoos, conditioners, body washes and liquid soaps. • Excellent broad-spectrum activity against bacteria, yeasts and moulds. Globally approved, Eco-friendly profile • Suitable alternative to parabens and formaldehyde releasers NEOLONE 950 Preservative • Single active preservative methylisothiazolinone chemistry • Effective broad-spectrum preservative • Compatible with a variety fungicides and bactericides • Simple, water-based formulation for ease of use • Effective alternative to formaldehyde releasers
Contact us: Johannesburg (011) 254 3300 | Cape Town (021) 534 3140 | Durban (031) 902 5324 East London (043) 726 8713 | Port Elizabeth (041) 453 1981
Crest Chemicals.indd 1
2017/01/31 11:13 AM
P C Review | JULY 2018 |
35
PRESERVATIVES
GLOBALLY APPROVED CPC APPEALS TO regulatory bodies and
Regulation. CPC is currently undergoing risk
consumers around the globe. From a
review as a new cosmetics preservative by the
regulatory perspective, the components of
European Scientific Committee on Consumer
Freshstat preservative options have been
Safety and is already approved as a personal
registered under the European Union’s REACH
care preservative ingredient in Japan.
a broad-spectrum preservative is ideal. Another consideration is the consistency of the formulation. Formulators must evaluate the impact a preservative may have on product separation, thus affecting its texture or thickness. There are also cultural and religious requirements worth considering. Freshstat is manufactured within Kosher and Halal certified conditions.
percentage of water they require preservatives,
For environmentally conscious consumers, CPC
like Freshstat Plus, which are highly effective
doesn’t persist in the environment. Paraben-free,
against mould.
phthalate-free, and eco-friendly, CPC addresses
Freshstat Plus is a proprietary mixture of CPC and benzoic acid in propylene
many considerations that may be on consumers’ minds as they evaluate and compare products.
glycol especially designed for use in
Formulators don’t need to worry about how CPC-
anionic surfactant systems, which
based ingredients will affect the appearance or the
need added preservation against mould and fungus. A dilemma
texture of the end-product because it is colourless, odourless and offers a neutral pH. These aspects
faced by many formulators
make it easy for a formulator to introduce CPC into
seeking to reduce or eliminate
an existing formulation.
traditional preservatives is finding a natural, paraben-free option
The Freshstat family of preservatives is available in South Africa from Millchem. •
with demonstrated effectiveness against an array of microbes that particularly threaten anionic
Millchem – www.millchem.co.za Vertellus – www.vertellus.com/freshstat
formulas. These threats include not only especially hardy species of mould, but also yeast, bacteria and fungi. To address the challenge,
REFERENCE: 1. The 2017 Label Insight Ingredient Confusion Study, https://www.labelinsight. com/ingredient-confusion-study
Shonna Twynham | Tel: 27 (0)11 922 1830 | Mobile: +27(0)79 372 0761 | Fax: +27(0) 11 976 1706 Email: Shonna.Twynham@chemsystems.co.za | www.chemsystems.co.za
36
| JULY 2018 | P C Review
Natural protection
PRESERVATIVES
for your formulations
Chemyunion, represented in South Africa by Chemgrit Cosmetics, has launched a new antimicrobial that broadens preservation possibilities in cosmetics products. Hebeatol CG is a bioactive molecule proven to prevent or delay microorganism growth. Figure 1: Challenge test results for Hebeatol CG in micellar water, wet wipes and mascara formulations
A
ccording to Chemyunion,
it is difficult to reduce allergic reactions
Hebeatol CG’s ability to prevent microbial
preservatives are frequently
and contact dermatitis in the medium and
contamination in micellar water, wet wipes
associated with contact allergies
long term with the current shrunken palette
and mascara formulations.
in cosmetics. Quaternium-15
of preservatives.
Developed by Chemyunion, Hebeatol
and formaldehyde are among the top 10
There are a few safe alternatives
allergens, based on the prevalence rate
on the market. Recent developments
antimicrobials, which includes Hebeatol Plus,
and clinical significance, listed in 2013 by
include sugar, fatty acid and amino
Hebeatol BA and Hebeatol PS VG.
the North American Contact Dermatitis
acid-derived ingredients, with excellent
Group (NACDG). In addition, Diazolidinyl
biological compatibility.
Urea (DIAZ), parabens, Imidazolidinyl Urea,
CG complements the Hebeatol range of
Hebeatol CG was developed using a green molecule obtained from a renewable resource. It is not only safe
Methylchloroisothiazolinone (CMIT) or
Safe and effective
and effective but also 100 percent
Methylisothiazolinone (MIT) are among the
Hebeatol CG is a functional ingredient that
biodegradable. As a functional ingredient
top 20 allergens listed by NACDG, which
acts as a broad-spectrum antimicrobial
it repairs skin’s barrier function, reducing
results in global restrictions imposed by
agent, providing formulators with a greater
transepidermal water loss by 21.
regulatory authorities.
opportunity to diversify their choice of
Hebeatol CG is ideal for skin care
preservatives. With a great synergetic
formulations and approved for use in a
list of preservative substances can result in
combination of xylitol esters and caprylyl
variety of countries. •
a higher incidence of primary sensitisation,
glycol, Hebeatol CG is compatible with a
because the same preservative is used in
variety of formulations and particularly great
a wide range of products concomitantly.
for micellar waters, wet wipes and mascaras.
This creates a paradox for formulators, as
See Figure 1 for challenge tests results of
Indeed, consumer exposure to a reduced
Chemgrit Cosmetics – www.chemgritcosmetics.co.za Chemyunion – www.chemyunion.com
P C Review | JULY 2018 |
37
PHARMA FOCUS//CAMs & Health Products
Natural remedy with
proven health improvement benefits
While healthy eating and increased physical activity are the keys to avoid or overcome problems related to metabolic syndrome, Metabolaid from Monteloeder has been proven to prevent and improve this condition.
M
chromatography coupled with mass spectrometry detection. Both plants have been readily used for centuries in traditional medicine to treat various illnesses or conditions. This unique, synergistic combination of ingredients results in a product that helps individuals with metabolic syndrome improve their state of health state. Metabolaid acts upon various tissues (adipose tissue, liver and muscles) by activating
etabolic syndrome consists of a
AMPK, which acts as a master metabolic
group of risk factors that affect the
switch. In the muscles, the phosphorylated
normal metabolic functioning of
form of AMPK (pAMPK) activates mechanisms
the body. It is not a disease, but a
to increase glucose and fatty acid uptake from the bloodstream, due to increased
series of unhealthy habits, or in some cases a hereditary metabolic condition, which, if not corrected, can eventually become irreversible. Its prevalence is growing
DID YOU KNOW?
mitochondrial biogenesis. Overall, Metabolaid favours the use of its own energy reservoirs
over other sources, making it an The prevalence of metabolic efficient fat burner. to increased physical inactivity, syndrome is increasing in African populations and is particularly high unhealthy eating habits, and among Black South African women Proven effective alcohol/tobacco consumption, (42 percent) versus women in the Clinical studies have among other reasons. With United Kingdom (23 percent) and demonstrated Metabolaid is an time, these conditions can the United States of America ideal product for individuals with become chronic and give rise to (36 percent). Source: excess weight, hypercholesterolemia/ https://bit.ly/2zapIg7 cardiovascular disease, diabetes, liver at an alarming rate worldwide due
hypertriglyceridemia, and/or
damage and cancer. Experts say one of the most effective ways
hyperglycemia, who wish to improve their
to turnaround this pandemic is through self-
health and quality of life. Clinical studies showed
care and not purely medical care. Metabolaid
Metabolaid helped volunteers:
from Monteloeder, available in South Africa
• lose weight (twice that of placebo group)
from Enna Industrial Ingredients (Enna II), is an
• reduce their waistline (-6.5cm)
active ingredient proven to prevent and improve
• reduce their body fat percentage (-2.0%)
metabolic syndrome.
• lower total cholesterol levels, especially
Metabolaid is the result of more than seven
LDL (-19.6%)
years’ scientific research in both animal models
• lower fasting blood glucose (-3.5%)
and clinical studies. These studies were performed
• lower heart rate (-8.4bpm)
in collaboration with renown experts, the Molecular and Cellular Biology Institute and Applied Biology Department of
• lower blood pressure (-14.6%) An increased satiety effect was observed in the volunteers taking Metabolaid, which was
Miguel Hernandez University (UMH),
perceived as early as 15 days after consuming the
Analytical Chemistry Department
ingredient (analysed using the VAS questionnaire).
of the University of Granada, the
In this manner, volunteers could more easily follow
Biomedical Research Unit of the University Hospital of Sant Joan and University Rovira i Virgili.
the diet plan, without feeling hungry and with a more positive attitude. Metabolaid can help with weight loss and to normalise cholesterol/triglyceride/glucose levels
A good combination
and blood pressure, while helping the user feel less
Metabolaid contains an
hungry. In this manner, it helps consumers follow
optimised combination of
a diet plan and increase their motivation and
polyphenolic extracts from Hibiscus sabdariffa (hibiscus) and
adherence to improve their health and quality of life. •
Lippia citriodora (lemon verbena), with a final content of 3.5 percent anthocyanins and 15 percent verbascoside as measured by high performance liquid
38
| JULY 2018 | P C Review
Enna II – www.ennaii.co.za Monteloeder – www.monteloeder.com/en/metabolaid
PHARMA FOCUS//CAMs & Health Products
New stability storage facility for CAMs and pharma products Stability programmes are fundamental in providing evidence of product quality after exposure to temperature and humidity variances. Stabil-Lab reveals why these programmes are essential.
G
lobal regulatory
So, it’s important to select an experienced
requirements necessitate
partner that offers efficient programme
the provision of evidence
management and flexible environmental
to support product shelf
condition capabilities that satisfy
life, recommended storage conditions
regulatory criteria for real time and
and ongoing stability programmes. This
accelerated stability studies.
ensures the product remains and, can be
The environmental chambers at Stabil-Lab’s facility are fully controlled and monitored
and technical expertise. ‘We also offer
expected to remain, within specifications
A trusted expert
under the storage conditions on the
Stabil-Lab is a dedicated facility, situated in
contingency and disaster recovery service
label. Stability programmes are used to
Boksburg, Gauteng, providing a one-stop
to help you mitigate the risks associated
demonstrate short and long term stability
stability solution. This includes:
with valuable stability trials,’ explains
of products including pharmaceuticals,
• development and management of
Dr. Herman Julsing, owner of Stabil- Lab.
a responsive and bespoke stability
complementary medicines or CAMs, active
stability programmes that meet the
pharmaceutical ingredients, bulk products,
regulatory requirements of the South
capacity and environmental chambers
finished products and cosmetics.
African Health Products Regulatory
qualified to a range of climatic zones, with
Authority, World Health Organization
back-up facilities and an uninterrupted
a stability programme is multifaceted; it
and the International Council for
power supply. ‘With the principles of
includes the preparation, implementation
Harmonisation of Technical Requirements
data integrity at the core of our data
and management of an appropriate
for Pharmaceuticals for Human Use
management system, Stabil-Lab provides a
The development and maintenance of
stability protocol, continued maintenance of qualified environmental chambers
• s torage of product samples in qualified environmental chambers
and constant monitoring and analysis
complete data dossier at the end of each storage interval. This gives an analysis of the
• continuous online monitoring of
of environmental conditions. These
The company has adequate sample
temperature and humidity data recorded
environmental conditions
throughout the entire storage period,’ he
programmes inherently demand
• collection and delivery of samples
comments. ‘We apply our comprehensive
considerable time and scientific expertise.
• an assortment of climatic zones.
understanding of the latest regulatory and
Table 1: Climatic zones
Temperature (°C) Humidity (% RH)
Zone II Long Term
Accelerated
Zone IV A
ZONE IV B
25 °C
40 °C
30 °C
30 °C
60%
75%
65%
75%
Stabil-Lab offers stability programmes for a range of climatic zones
Contact details: Dr. Herman Julsing 0824970250 support@stabillab.com
Stabil-Lab.indd 1
The Stabil-Lab team
technological developments. This offers a
provides professionally
responsive partnership with an integrated
managed cGMP
storage capability, allowing clients to focus
compliant stability
on their core business objectives.’ •
programmes, for all products, supported by years of scientific
A pharmaceutical stability storage facility to monitor all types of pharmaceutical dosage forms.
Stabil-Lab – www.stabillab.com
Stabil-Lab now offers a complete stability storage service to take the headache out of your stability programme. Monthly billing that can easily be accommodated, complete data dossier to fully comply with SAHPRA requirements. Building of stability chambers. No problem with power outages. Off site storage for better thermal and security control. Peace of mind with your stability programme.
2018/07/04 11:27 AM
P C Review | JULY 2018 |
39
PHARMA FOCUS//CAMs & Health Products
The green revolution in integrative healthcare
It’s going to take strategic efforts of government, industry and healthcare practitioners to achieve an integrative system of complementary and allopathic medicine. Raj Naidoo, professor emeritus of Nelson Mandela University, discusses the growing trend in natural healthcare and how all industry role players are responsible for meeting consumers’ needs with safe and effective products.
C
mutually equitable partnerships that adopt jointly accountable, ethical and holistic approaches to patient care.
Role players in safety and patient care The pharmaceutical interface at points of manufacture and sales, particularly manufacturing, can become an
omplementary and
or even alternative, mostly off-the shelf
instrument for facilitating integrative
alternative medicine (CAMs)
therapeutic products, have evolved.
healthcare practices for patient care.
is becoming recognised
Yet, the potential for their integration into
As noble as it may seem to conjoin
nowadays as complementary
mainstream healthcare services raises some
a diverse range of allopathic and
challenging issues.
alternative therapeutic products, safety,
and integrative medicine (CIM) or, more appropriately, as ‘complementary and
efficacy and quality issues need to be
integrative healthcare’. It has been well-
Challenges to integration
considered. Plant derived herbals and
positioned globally in an out of the box,
Our current terminology, which alludes
homeopathic remedies are no different
natural health solution seeking world. This
to alternative products or services,
to chemical agents that undergo
growing trend occurs against a backdrop
has become politically inclusive by
scientific and regulatory scrutiny. Since
of globalisation, legislation and migrating
describing them as ‘complementary’.
the health and safety of the patient/
cultures with diverse cultural traditions in
Alternative treatment modalities hopeful
consumer is paramount, in this regard
tow. Besides a host of alternative treatment
of becoming mutually inclusive and thus
industry has a meaningful role to play.
applications and services, the commodity
complementary and integrated with that
By providing the assurance required by
applications of natural, complementary
of the more mainstream sector have a
health professionals, quality assured
gap to bridge through scientific scrutiny
products instil a level of confidence
and validity.
in all stakeholders. Assuring quality
THE RISE OF WELLCARE
With traditional and deeply entrenched
standards in regulatory submissions
belief systems, popular alternative
and standard operating procedures
treatments face their share of challenges
for Good Manufacturing Practice,
for an acceptable level of integration into
mitigates the risk to manufacturer and
THE INCREASING DEMAND for preventive
mainstream allopathy. One of which is
patient. Inter-professional confidence
health measures and general well-being has
mainly due to inter-disciplinary practice
can be instilled between alternative and
led to the emergence of a new market PwC
logistics and professional silos with their
allopathic sectors. This would enable
defines as ‘wellcare’. Products in this new health
scopes of practice that dictate the terms
the discovery and development of a
economy encompass a wider range of both
of association. For now, this precludes a
balanced relationship through confident
pharma and non-prescription consumer offerings
true, fully integrative healthcare solution
partnerships via products that could
aimed largely at preventive care, nutrition, fitness
on a broader scale between practitioners
safely benefit the end-user. Of course,
and cosmetic enhancement. PwC estimates
registered across the various professional
this is dependent upon a fluid regulatory
the total global value of the wellcare market is
boards of allopathy and alternative
system that meets on-time demands of
US$674 billion, with many product categories
systems. To each his or her own, an
manufacturers and a respectful willingness
expected to grow at a rate of double digits.
integrated working relationship implies
amongst healthcare practitioners to
an ‘under one roof’ establishment, with
merge their respective domains.
40
| JULY 2018 | P C Review
PHARMA FOCUS//CAMs & Health Products The growing natural
extraction and purification
healthcare trend is evidenced
processes, and insight into
by consumers’ greater need to
stability profiles become
court nature, especially for oral
crucial areas of control
consumption, in the hope that
compared to consistently
all will be better organically. This implicit
derived chemical
trust in nature has led to a common
synthetics. Implicit trust in
belief that natural is organically good
the integrity of suppliers’
and relatively safer than synthetic
certificates of analysis
medicines. However, this notion needs
may not be so reliant
tempering. Because of its flip side,
these days and visits to
so-called natural products
the source of supply could
carry inherent risks of safety and
be necessary for further
potential untoward reactions
authentication. During
if not clinically understood, nor
transportation, sensitive
fully evaluated and classified for safety, efficacy and quality. This includes the potential risk of drug-
materials require suitable
The emergence of the herbal renaissance has necessitated careful scrutiny of raw materials
storage areas away
seen as self-help wellness commodities by consumers and marketers. Pharmacists, as stockists of these products, require in-depth nutritional insight in relation to drug therapy. This is especially so as nutritional supplements in combination with herbal ingredients are often encountered in proprietary formulations. Such insight needs bolstering through
from volatiles and fluorescent lighting or
relevant education programmes and
where they may be exposed to undue
consultation with dieticians, the latter
vibration. This may even go as far as the
being a prime example of integration
stipulation wooden shelving as opposed
within the mainstream sectors. Such
Alternative medicinal products, from a
to metal, particularly for the stability of
primary integration is complementary in
purely pharmaceutical perspective, as
homeopathic preparations.
the broader sense and does not involve
herb interactions.
Regulatory perspective
well as homeopathic remedies and others
alternative modalities of treatment
of plant, mineral and animal origin, require
More in the mix
unless nutritional therapy supersedes
the best in the business of scientific scrutiny
The South African healthcare scene
drug therapy.
for assured safety, efficacy and quality.
cannot ignore the vast pool of traditional
This is backed by regulatory demand
healers, who practise African traditional
into healthcare scenarios has
and evidenced by the number of quality
medicine, serving a prominent sector of
brought about a paradigm shift in the
control services in product development
the population through their cultural rituals
consumer mind set, as well as patients’
and manufacture, advertised in P C
and indigenous ‘muti’. A deep-set belief
requirements and expectations. The
Review. This shows industry is staying
in ancestral heritage and causality by
natural trend in therapeutics and even
ahead of the pack and cognisant of the
practitioner and patient alike, necessitates
skin care presents new challenges both
need to be proactive, even to the point of
a closer look at an Afro-centric expression
for the practitioner and manufacture
self-regulation. If the South African Health
of holism and indigenous knowledge of
and brand owner. Perhaps these
Products Regulatory Authority (SAHPRA)
medicinal substances inherent in plant
parties need to embrace and
means business as usual with the growing
and animal tissue. Match this with modern
complement each other synergistically,
backlog, then self-regulation on the part of
science and the beating of the drums
thereby enabling holistically safe
manufacturers, becomes ever so critical.
sound numerous challenges.
and effective integrative healthcare
Yet it is hoped SAHPRA, with its intended
The Traditional Health Practitioners Act
The advent of the green revolution
prospects for the South African market,
fast track system, would expedite matters
2007 (Act No 22 of 2007) literally expresses
healthcare practitioners
more effectively in the future.
the spirit of intent by the Department
and patients
of Health, which made provision for a
or consumers. •
The days of pharmacognosy, which vintage pharmacists
Traditional Health Practitioners Council to
would recognise, have
regulate practice, as it also recognises
been replaced by pharmacognisance, of safety, efficacy
the material worth and economic impact of African traditional healers and their medicines. With
and quality, to which
an estimated 200 000+
one should also
African traditional
add value in terms of
healers in South
pharmacoeconomics. On
Africa, the concept of
two fronts, manufacturing
registration to many who
and distribution, including
operate in the informal
the retail sector, the emergence of the herbal renaissance has
sector, appears foreign. Nutritional
necessitated careful scrutiny
supplementation products
of raw materials. Plant source
have also ventured into
variability, cultivation consistency,
the CAMs or CIM domain.
traceability, handling and storage,
More often these are
ABOUT Raj Naidoo is professor emeritus at Nelson Mandela University (NMU), faculty of health sciences, department of pharmacy, based in Port Elizabeth. He conducts teaching and research in an elective programme on complementary and alternative medicine for pharmacy students. Previously, Naidoo taught pharmaceutics and pharma technology. He is also a member of the editorial advisory board of P C Review.
P C Review | JULY 2018 |
41
PHARMA FOCUS//CAMs & Health Products
UNITED IN THE DRIVE for preventative healthcare The HPA has not rested its efforts to find a practical and workable solution for regulating the CAMs and health supplements industry. It continues to lobby with government and, at the same time, is educating the public on the benefits of preventative healthcare. By Abby Vorster
With the hope of bringing this approach to South Africa, Ascencao says the HPA will continue its high level collaborative efforts with the Department of Health and SAHPRA to strengthen their understanding of CAMs and health supplements. These efforts include the HPA’s listing system, which has been revised to incorporate an electronic notification and registration system used internationally by the
C
association’s peers. onsumer awareness about
‘We have also upscaled our communications
well-being and preventative
strategy around the benefits of our industry, both
healthcare has evolved. This
through civil and government campaigns detailing
is particularly true among an
how the HPA helps people stay healthy and
ageing population, where people need
contributes to lowered healthcare costs,’ she adds.
to maintain their health for longer with the help of preventative products. Preventative
Collaboration continues
healthcare could play a significant
Wayne Robinson, HPA’s director of scientific and
role in minimising individual demands
regulatory affairs, has been engaging with the ITG,
on South Africa’s public healthcare
which he says is in favour of the HPA’s suggested
system, which caters for 84 percent of the population. It could contribute to keeping the system efficient, affordable and
listing system. ‘Yet there is serious concern regarding the enormous backlog of dossiers both in the pharma and CAMs industries. There is also concern
functioning smoothly yet preventative healthcare
that many registrations will not be assessed in the
products such as complementary medicines (CAMs),
sequence of submission of dates,’ he comments.
vitamins and nutritional supplements continue to be
‘Added to this, SAHPRA has admitted that there is a
misunderstood from a regulatory perspective.
resource constraint within the authority which further
According to the Health Products Association of South Africa (HPA), the proposed regulations are
compounds the situation.’ As noted at the recent CEO meetings with SAHPRA,
untenable for all CAMs and health supplement companies. Yet the HPA is positive that the current situation can be rectified through the CAMs Industry Task Group (ITG) and a collaborative approach with South African Health Products Regulatory Authority (SAHPRA) to determine the best compromises in order to have safe and appropriate Maria Ascencao
the HPA is positive the authority is
HPA is positive the authority is open to fresh ideas
regulations for CAMS and health/ nutritional supplements.
open to fresh ideas to overcome these issues. ‘HPA has requested follow-up engagements directly with SAHPRA to ensure we keep the momentum high,’ adds Robinson. Ultimately, it will require industry involvement, insight into international standards and processes, recognition of foreign registrations in certain jurisdictions
and improved communication between SAHPRA and the industry to find a workable solution for the
Essential for a healthy nation
efficient, appropriate, transparent and cost-effective
Worldwide, there is a category called dietary/food
registration and listing process for CAMs and
supplements or natural health products, which falls
health supplements.
completely outside of the category for medicines.
Wayne Robinson
42
Time is of the essence, as new product innovation
Maria Ascencao, chairperson of the HPA, says: ‘The
has come to a virtual standstill, as a result of the
European Food Safety Authority (EFSA) is an example
continued regulatory sagas. ‘By stifling future
of a regulator that has developed an excellent system
discoveries and innovations, the regulators are
with the help of scientists and industry stakeholders,
exerting control over South African consumers’ health
to categorise a nutritional or health supplement and
options and preventing an untold number of CAMs
develop guidelines for the associated functional
and nutritional supplement benefits from reaching
claims and permitted substances etc. all focused on
the public, promoting wellness and driving down
bringing health to the nation.’
healthcare costs,’ Ascencao concludes. •
| JULY 2018 | P C Review
PackagingREVIEW SOUTH AFRICAN
www.pharmacos.co.za
July 2018 | Volume 44 | Number 7
What’s hot in inks
and decorative finishes
Shrink sleeves: Your 360˚ shelf shout solution
Bosch steps away from packaging
NEWS
Your link to the best in ink WITH SO MANY products on the market, each pack has a few seconds to create a lasting impression. Primarily, ‘shelf shout’ is what packaging is about. Striking bold colours, designs, icons and typography must work in harmony to inspire purchases. As easy as it seems, getting the colour right and producing a pack that lives up to a product’s desired intent can be quite a challenge for designers and converters. The process of specifying a colour with a spectral value is easy, the trick lies in the end result. The selection process can be completely overwhelming given the variety of available substrates and decorative finishes. Albeit familiar techniques, embossing, debossing, die-cutting, spot varnishes and more, combined with high quality special effect inks can create unique impactful
BOPP film on wet wipes
secondary packaging. UV paste and flexographic and screen inks remain largely popular owing to their fast curing process. This means printers save energy whilst simultaneously reaching high throughputs. Turn to page 45 for more insight into the latest inks trends and decorative effects. Until next month! Assistant Editor Aarifah.Nosarka@newmediapub.co.za
A ROBUST FILM FOR RE-SEALABLE APPLICATIONS INNOVIA FILMS IS set to launch a new
BOSCH TO SELL ITS PACKAGING BUSINESS THE COMPANY RECENTLY announced
‘This decision will allow Bosch
a decision to sell its pharma and
to narrow its focus on issues of
food unit’s Packaging Technology
importance for its future. These will
division (PA). This follows intensive and
include the transformation of the Bosch
thorough considerations by the group.
Group and its future digitalisation
It has decided packaging technology
strategy. This extends to the internet
is not part of its core business. PA is
of things and pooling of its resources
involved in project business relating
accordingly,’ says Dr Stefan Hartung,
to specialised areas of the packaging
the Bosch board of management
industry. The company also operates
member responsible for the energy
in a competitive environment in which
and building technology and industrial
the players are small and medium-
technology business sectors.
sized enterprises (SMEs) with a structural advantage. Bosch believes its packaging
He explains Bosch and the PA division will benefit from this decision. ‘A reorganised packaging
technology operations must be
technology business will be able to
placed on a different footing to allow
adapt more flexibly to the diverse
it to react flexibly to the specific
requirements of this typically SME
requirements of the packaging
market. This, while Bosch is able
machinery market. Its special-purpose
to focus its attention entirely on
machinery manufacturer, Robert Bosch
the group’s impending profound
Manufacturing Solutions is a separate
transformation,’ Hartung adds.
entity in Germany and will remain part of the Bosch Group.
The group’s strategy is to structure its operations competitively.
biaxially oriented polypropylene (BOPP) Rayoface facestock film specifically designed for wet wipes applications. This strength of this clear films is derived from its thickness, which is 92 microns. The film has exceptional clarity despite its thickness. It also has a special print and adhesive receptive coating to ensure high quality print performance. The company’s global product manager for labels, Richard Southward says the market for wet wipes has grown considerably over the last few years. ‘Brand managers have tried a number of options to improve consumers’ experience when opening and reclosing packs. We have taken on board the various requirements shared with us and are confident that our strong recloseable film is ideal for large and small packs alike,’ he comments. The film is robust, which allows packs to be easily opened and re-sealed without the loss of stiffness. ‘The fact this performance can be achieved with a mono film eliminates the need to laminate several layers together, which reduces costs and resources,’ says Southward. A variety of print processes, including offset, screen, letterpress and flexography
A Bosch packaging system
can be used to print this particular film. BOPP’s natural resistance to moisture ensures it will perform on a wide range of pack sizes across different applications such as home and personal care products. The company’s sales agent, Jan van Heule provides services to clients in Africa and the South African region.
44
| JULY 2018 | Packaging Review
INKS & PRINT FINISHES
Fashion packs your way Beauty brands rely on high quality inks, coatings and finishes to transform ordinary packaging into extraordinary packs with strong shelf appeal. Scratch and chemical abrasion resistance also needs to be taken into consideration when specifying a finish.
T
he market for print finishes
only enhancing a brand but also the
on cosmetics packaging is
consumer’s experience.
becoming more high end. This is
soft satin feel making them feel and
ColorGen, who says this is especially the
look high value,’ Rodway comments.
case when a finish represents a brand
Its major advantage is the matte
or product.
effect, which prevents finger marks on
a coating or a laminate,’ he explains.
on regulatory compliance when it comes to labelling, which must be attached to the
The technology can be printed economically on individual packs, vials and syringes. CTI’s capability embeds the technology into an ink system that can be incorporated into the existing packaging printing process. This also guarantees billions of packs of vaccines can be individually inspected for quality and safety.
and overprinting.
soft touch feel, achieved using
there is more emphasis
product wastages.
packaging and allows for hot stamping
has moved towards a matte or
For pharma packaging,
It also helps brands save money by lowering
‘It gives all cosmetics products a
according to Quinten Rodway, GM at
‘A big part of the cosmetics market
healthcare products and medical supplies.
DID YOU KNOW?
In printing, soft touch is a generic reference to any finishing method that adds a velvety soft feel to the print material.
He says the company has witnessed significant growth in high end products with value add
‘Every packaging company in the world
in terms of aesthetics and
that supports pharma and healthcare
tactile effects. It is also
clients just received access to a new
advantageous to have
pipeline of innovation. This will help their
migration compliant inks.
clients improve quality and safety while
product for extended information purposes. Over printable varnishes have
NEW FREEZE-WARNING TECHNOLOGY
been used for variable information,
Biopharmaceutical products are
coding, batch numbering and expiry
temperature sensitive and any exposure
dates etc.
to temp variances in the cold chain can
‘Most big brand owners use
result in their loss of efficacy. To counter
fluorescent varnishes and foiling for
this issue, Chromatic Technologies
identification and anti-counterfeit
(CTI) introduced a new freeze-warning
purposes,’ Rodway adds.
ink technology. The BlindSpotz ink was
There is also a trend towards using
developed in partnership with the
high end inks and coatings with added
American Thermal Instruments (ATI) to
value laminate and compliant products
help protect brands and consumers of
with low volatile organic compounds. ‘There has been a massive focus on UV inks and coatings where low migration products have been specified. A unique offering is soft touch varnish, which can be applied to most print processes.’ One benefit of soft touch varnish is its strong scuff resistant property. It’s
Soft touch varnish gives all cosmetics products a soft satin feel, making them feel and look high value
creating a better consumer experience. It just requires one print station and the technology can be implemented,’ says Patrick Edson, CTI’s chief marketing officer. The ability to now record data and inspect at packaging level is an economical, dramatic improvement in monitoring and reporting. BlindSpotz is available in UV and water-based flexo, water-based gravure, wet offset, UV wet offset ink formulas and finished devices. Additional technology for devices and on-pack printing is available to alert the user or supplier of thawing, the product warming outside of refrigeration specifications, high-heat damage and tampering. •
ColorGen – www.colorgen.co.za Chromatic Ink Technologies – www. www.ctiinks.com
a great tool for emotional marketing and a way of distinguishing a brand or a product from competitor offerings. This water based FDA approved technology is migration compliant, not
The bottle on the left shows the product is safe for use whilst the bottle on the right indicates exposure to temperature variances which has resulted in the loss of product efficacy. This is when the ‘frozen, do not use’ inked text appears.
Packaging Review | JULY 2018 |
45
LABELLING
The third degree on 360° label coverage Innovation Shrink and Wrap is pushing boundaries in decorative finishes. Aarifah Nosarka looks at what makes this company a one-stop shrink sleeve and label design shop.
T
he Edenvale based company has
is texture to impart luxury
been working on domed varnish
and create a more visceral
finishes and silkscreen printing,
connection between brand
which is a unique way to add elegance
and consumer.
to products. Daniel Hanson, co-owner of Innovation Shrink and Wrap (ISW),
MORE THAN DECORATIVE
says the company provides excellent
‘Holographic shrink sleeves
decorative finishes. ‘This is proof we strive
are a reliable security solution
to supply the best to our clients and
to protect branded products
are prepared to take on any complex
against counterfeiting. Our
challenge regardless of quantity.’
sleeves can be engineered
The domed varnish finish is an
to incorporate a tamper-
example. By manipulating PE or metallic
evident holographic strip safely
foil substrates then printing using silk-
attached to the product,’
screening, varnish, and other embossing
Hanson explains.
processes, ISW creates products that
The impressions of holograms on
outshine all others and ensure clients’
hot stamping foils are embossed on a
products stand out.
lacquered, metallised polyester film.
The competition for shelf space has
dergoing Products un rough a th ing am ste el nn tu am ste
A special adhesive coating is used
become more aggressive than ever. This
on the foil, which enables the transfer
is evident in the increasingly advanced
of the holographic image onto the
label decorations used by many
substrate using the company’s adapted
brands. Shrink sleeves create maximum
foiling process.
graphic appeal, allowing the use of custom package shapes and 360° graphic coverage of the container. Many brand managers want a metallic look, and/ or textured feel on their packaging because it gives a more luxurious finish. ISW
The company uses the services
DID YOU KNOW?
A shrink film can be made to shrink in one direction, unidirectional, monodirectionally or bidirectional.
continues to achieve this whilst delivering the ‘what’s next’, which
of Revolution Rapid Shrink Application (Revo) for its R&D of sleeves, which are applied to uniquely shaped containers. These sleeves incorporate complex decorative designs. Hanson says it is pertinent a beautifully designed and
produced sleeve is not ruined during the final step of application as a result
Shrink sleeve films and on products
of poor R&D. ‘This can ultimately have a
and share the technical knowledge each organisation has. When ISW develops a new sleeve for a customer, this is done in conjunction with Revo to ensure when the sleeve is applied, everything is perfect. Packology in partnership with Revo specialises in short run shrink sleeve applications. ‘This challenges our packing lines because of artwork demands and the primary packaging shapes and gauges requested,’ says Brett Collett, MD of Packology, which has a unique approach to the contract application of shrink sleeves. Customers can enjoy the attention of ISW and Revo’s teams. ‘Our services are ideal for SMEs and start-ups looking to gain market share and brand acceptance. Their challenge is the greatest. They look at ways to launch premium packs without the volumes. It
negative effect on the finished product.’
is assumed low volumes demand basic
A PERFECT FIT
required to launch of a premium product.
Revo and ISW have fostered a mutually beneficial relationship, which is reaping the rewards for their shared customers. When the directors of both companies met, they quickly discovered
packaging or high volumes of capital are This is not so as there are affordable options in the market. A professionally decorated product can be produced. This can then be done in short runs to the market,’ says Collett. •
that there was a shared belief that the South African packaging industry should foster a culture of collaboration
46
| JULY 2018 | Packaging Review
Innovation Shrink and Wrap – www.iswshrink.co.za Packology – www.shrink-sleeve-labels.co.za
ASSOCIATION NEWS//
First lady chair
for GBMSA in four decades
L
orraine Keyser is the first female
She explains: ‘In the USA and Europe,
elected as chairperson of GBMSA
generics account for about 80 percent
since its inception 41 years ago.
of all medicines dispensed. For every one
Keyser is known in the industry for her
percent increase in generics usage in
role as country manager at Dr Reddy’s.
South Africa there is an annual saving of
She brings over 20 years’ experience in
R30 million for patients or payers. These
pharma manufacturing to this role.
funds could be ploughed back into the
‘I am excited at the prospect of
threaten to undermine health budgets within the private and public sectors.
It is going to be up to the GBMSA board to support manufacturers
health system to assist in the quest for
leading the GBMSA. I look forward
universal healthcare.’
to the opportunities
‘Just as generics have made traditional medicines more affordable, biosimilar
to drive increased
ADVOCATE FOR INDUSTRY
medicines offer the potential for patients
access to healthcare
Keyser’s appointment
to enjoy access to life saving bio-therapies
for more South Africans
comes at a critical time in
at a fraction of the cost of their branded
through greater use
our country’s healthcare
counterparts. It’s going to be up to the
of generic medicines,’
lifecycle. On the one hand
GBMSA board to support manufacturers
she comments.
there is a need for increased
of these medicines and to advocate for
savings and efficiencies
the timeous registration of these products,’
in South Africa has risen to
in order to implement a
she concludes. •
an impressive 64 percent,
sustainable NHI. On the
While the use of generics
Keyser believes there is still significant room for growth.
Lorraine Ke
other, biomedicine and
yser
technology advances
GBMSA – www.gbmsa.org
MCA’s new website guided by updated code An updated code, new branding and fresh website were introduced at the MCA’s AGM on 21 June at the Johannesburg Country Club, in Woodmead, Gauteng.
T
he adoption of the Marketing Code Authority’s
on complaints and any party can lodge a complaint
(MCA) Code v11 and Guidelines v9 was
against one of its member companies. Sanctions and
unanimous at the AGM. This latest version of the
fines may be issued.
code takes into account the global landscape, looking at ethical marketing trends in the US, Europe and the
PLATFORM FOR DIALOGUE
UK, to ensure South Africa is relevant.
One of goals of the refreshed business to business
Wayne McDuling, chairperson of the MCA, explained
MCA website will be to enable communication between
there is a paradigm shift in the market so Code v11 has
government; medical device, pharma and CAMs
advanced from being rules based to a principles based
businesses; healthcare professionals and consumers. It
system. ‘The rules won’t disappear as they are the
will open up access to healthcare practitioners and the
foundation. Yet ethical marketing needs to be taken to
public to lay complaints in terms of the Code.
a completely new level, which sits within the principles of this practice.’ The MCA Code sets the rules of engagement between the supplier and the healthcare professional
The homepage will feature a detailed infographic with each section hyperlinked to content on the MCA, to provide an easy to use public interface with the authority.
for marketing and selling activities and sponsorship for
All customer facing company staff are expected
educational meetings. It applies to healthcare products
to be certified as competent in the application of the
only and not cosmetics, and disallows funding of any
Code and the new website will continue to provide
entertainment or sporting events. The MCA adjudicates
this functionality.
48
| JULY 2018 | P C Review
Val Beaumont, MCA’s executive director; Griffith Molewa, head of law enforcement at SAHPRA; and Wayne McDuling, MCA’s chairperson shake hands, showing the industry body and SAHPRA’s willingness to work together to enforce ethical marketing and promotional activities
Company signatories of the MCA’s Code of Marketing Practice are committed to marketing their products to healthcare professionals, patients and consumers in an ethical manner and in line with international best practice. The best interests of the patient or consumer should come first in health product selection. Healthcare professionals should not be incentivised to select any health product, be it medical device, IVD or medicine. The support the industry brings in terms of healthcare education is highly valued and makes a significant contribution to the continuing professional development of healthcare practitioners. •
Marketing Code Authority – www.marketingcode.co.za
ASSOCIATION NEWS//
The world of fragrance explored Coschem hosted a creative morning refresher on 13 June with a host of young and passionate presenters who covered everything related to fragrances.
IADSA honours Bruce Dennison
P
resident of the Health Products Association of South Africa (HPA), Bruce Dennison has
been honoured for his contribution to the International Alliance of Dietary/ Food Supplement Association (IADSA). The association celebrated its 20 th anniversary in June, in London, UK, where the honorary mention of Dennison’s contribution to the global health and wellness industry occurred, much to his surprise. Dennison was on the board of IADSA and previously held the position of vice chair. ‘It is through his auspices that IADSA has been very loyal and helpful to the HPA over these many years,’ says
Delegates, presenters and members of the seminar committee who attended Coschem’s morning refresher on fragrances
M
the HPA’s Deirdre Allen. ‘This is a very well deserved and an appropriate
arie Aoun of Saint d’Ici,
as customisation, where consumers
honour to Bruce. Congratulations;
the natural and limited
create their own fragrance of choice at
here’s to another 20 years’ service and
edition parfumerie based in
specialised outlets.
dedication to our industry!’
Johannesburg, shared insight into local
Fragrance translation – from mind to
and international natural perfumers
market was the focus of Givaudan’s Vipul
and perfumery brands. She also looked
Suri and Ofentse Tsipa, who discussed
at what constitutes a natural perfume;
the structure and composition of a
discussed isolates, niche markets and
fragrance and the olfactive families.
suppliers and shared industry challenges and opportunities for growth. Fragrance and its application for
INFLUENTIAL MILLENNIALS
Bruce Dennison and IADSA’s outgoing chairman, Ric Hobby of Herbalife
Tiffany de Astui of Carst & Walker
innovation were highlighted by Kelefang
showcased a variety of new fragrances
Mofokeng of Sensory FX. She provided
aimed at the millennial generation.
answers to questions such as what drives
‘Representing over a quarter of the
innovation and why it is crucial to the
global population, millennials are
fragrance industry’s continuing success.
the most influential consumers yet
Mofokeng also revealed how the history of
difficult to define due to their multiple
perfume and fragrance profiles, methods
contradictions,’ explained De Astui.
of production and historical consumption
‘The fragrance wardrobe concept has
set the stage for today’s innovation in
become very popular with millennials
the industry.
because they can personalise and match their scent to their mood,
TRENDS AND TRANSLATION
style and way of life. Their preferred
Zodwa Ndebele of Orkila covered latest
fragrances are often freedom-loving,
fragrance trends. ‘We are seeing more
elegant and playful with fresh, youthful
products on the market formulated with
and sparkling facets that please the
natural ingredients and an increasing
millennial generation.’ •
need for fragrances to support this trend,’ she commented. Genderless fragrances are also on the rise as well
Coschem – www.coschem.co.za
Dennison was given the honour of cutting the cake at IADSA’s 20 th anniversary
P C Review | JULY 2018 |
49
Tea time TO ADVERTISE IN Anita Raath Sales executive
+27 (0)82 976 6541
Solution 6
3
8
1
3
4
5
2
7
6
2
9
1
5
5 2 9 6 7 4 8 3
7 1 2 9 8 5 4 6
4 5 6 7 1 8 3 2
2 8 3 5 4 1 7 9
6 7 5 8 3 9 1 4
3 9 4 1 6 2 5 7
1 4 7 2 9 3 6 8
ADVERTISERS' INDEX
9
8
5
| JULY 2018 | P C Review
8
50
2
Acacia Chemicals....................................27.........www.acaciachem.co.za Aerosol & Cosmetic Works....................... 17.........www.serosolcosmetics.co.za Amchem............................................... OBC.........www.amchem.co.za Botanichem.............................................31.........www.botanichem.co.za Britepak................................................... 12.........www.britepak.co.za Chem Systems.........................................36.........www.chemsystems.co.za Chempure...............................................29.........www.chempure.co.za CJP Chemicals........................................34.........www.cjpchemicals.co.za Crest Chemicals......................................35.........www.crestchemicals.co.za Croda......................................................25.........www.crodapersonalcare.com Enna........................................................ 15.........www.ennaii.co.za Evonik......................................................37.........www.evonik.com
6
+27 (0)71 438 1918
9
Sales executive
3
Candida Giambo-Kruger
1
+27 (0)83 260 6060
4
Sales executive
7
Carla Melless
Hersol Manufacturing Laboratories....... OFC.........www.hersol.co.za ISW Shrink...............................................47.........www.iswshrink.co.za Millchem.................................................23.........www.millchem.co.za Omron..................................................... 19.........www.industrial.omron.co.za Orkila.......................................................24.........www.orkila.com Pyrotec......................................................5.........www.packmark.co.za Savannah Fine Chemicals........................33.........www.savannah.co.za Sensient Colors....................................... 14.........www.sensientpharma.com Serendipity Toiletries................................22.........www.serendipitytoiletries.co.za Solo Chem............................................... 13.........www.sologroup.co.za Stabil-Lab................................................39.........www.stabilab.com Stone Hard Projects................................ IFC.........www.stonehardprojects.co.za
Online
INDUSTRY WEB REVIEW ESSENTIAL SPECIALISED PRODUCTS
COSCHEM
Supplier of cosmetic and personal care ingredients.
Visitors to the Society of
Ingredients include; Bioferments, Botanical Extracts, Delivery
Cosmetic Chemists’ website will
Systems, Enzymes, Functional Actives, Silicones, Emollients,
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Emulsifiers, Meadowfoam Seed Oil & Derivatives, Abyssinian and
educational programmes
other Oils, Shea and other Butters, Aliphatic Hydrocarbons, Lanolin
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& Derivatives
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www.coschem.co.za
M&L LABORATORY M&L Laboratory Services (Pty) Ltd, provides clients with an extensive array of analytical capabilities. M&L renders testing services to the Food & Beverage, Mining, Environmental, Water &
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closures. We are official distributors for Consol Glass. Dalgen is
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LOOK GOOD FEEL BETTER
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Your No. 1 industry leader
offers support to cancer patients focusing on emotional and social
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At 2 hour interactive workshops held in oncology units across
natural colours – used in food,
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Tablet coatings – manufactured,
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