Issue 9 Year in Review by OU-Surgery

DEPARTMENT OF SURGERY

2024YEAR INREVIEW

Address

DepartmentofSurgery

AndrewsAcademicTower

800StantonL YoungBlvd #9000 OklahomaCity,OK73104

Letter from the Chair

WelcometotheDepartmentofSurgeryNewsletter!

Thisissuescovers2024aswesharetheincrediblebasicscience, translational science, and clinical innovation our department faculty are contributing to academic surgery. As the field of surgery evolves, so does our department and we highlight the amazingaccomplishments.During2024,wecontinuedtoexcel with our missions, grew as a department, and added to our individualaccomplishments.

(405)271-7912Office (405)271-3919Fax

Phone Email

barish-edil@ou.edu

Finance | Administration

JessicaCapetillo

ExecutiveAssistant/ SeniorAdministrativeManager

KatherineWhite ExecutiveAssistantII

AmberRice DepartmentSurgeryScheduler

MarlowBrooks OUHSCITAnalyst

LisaSuriano SeniorClinicalBusiness Administrator

HeatherDees AccountantManager

MarySheets SeniorAccountant

MarloSoutherland,SHRM-CP LeadAdministrative/Finance Coordinator

Weareconstantlystrivingtoimproveandinnovatewhichkeeps usattheforefrontintheworldofsurgicaladvancements.Ihope that you enjoy looking through all the events, but, most importantly,takepride,asIdid,inourmanyaccomplishments in2024.

I would like to thank the entire department for your poise, patience, and perseverance as our academic landscape is continually shifting. I am extremely proud of your leadership, academicvigor,anddedicationtoourstudentsandresidents.

Finally, I would like to congratulate our graduates who will continue OU Surgery’s legacy as they begin their fellowships andpractices

Thank you for your interest in our newsletter and I hope you finditinfor

Sincerely, BarishH.Edil,MD Professor&Chair

Whenthemissionispure,itmakestheworkeasier

Mission

Toimprovethehealthofallpeople,to deliver excellent, innovative patient care, advance the science of surgery and to educate health professionals, physicians, and surgeons for the future.

Vision

Leadingthenationasa

TopTierDepartmentofSurgery

Values

Excellence,Integrity, Collegiality,Compassion

JasonT.Cheng,MD AssistantProfessor TransplantHepatologist

ArthurGrimes,MD AssistantProfessor AcuteSurgeryCare&Burns

ShinobuItagaki,MD AssistantProfessor Cardiac,Thoracic&VascularSurgery

2024NewFaculty

PauloMartins,MD AssociateProfessor TransplantSurgery

TaylorMartin,MD AssistantProfessor AcuteSurgeryCare&Burns

PaulMcGaha,MD AssistantProfessor PediatricSurgery

MuhammadPanezai,MD TransplantNephrologist

BradleyPhillips,MD AssistantProfessor AcuteSurgeryCare&Burns

NanaToyoda,MD AssistantProfessor Cardiac,Thoracic&VascularSurgery

NeilM.Venardos,MD AssistantProfessor Cardiac,Thoracic&VascularSurgery

JasonS Lees,MD,FACS

RobertD Gordon,Jr ProfessorofSurgery SectionChiefAcuteCareSurgery&Burns AssociateDeanofGraduateMedical Education-DesignatedInstitutionalOfficial ViceChairofEducation OUCollegeofMedicine|OUHealth DepartmentofSurgery

AcademicFaculty

ScottBlair,DO AssistantProfessor

MorganBonds,MD AssistantProfessor

AlisaCross,MD AssociateProfessor

ArthurGrimes,MD AssistantProfessor

TaylorMartin,MD AssistantProfessor

ChanceNichols,MD AssistantProfessor

BradleyPhillips,MD AssociateProfessor

CeliaQuang-Blair, MD AssistantProfessor

EmilySwitzer,MD AssistantProfessor

FrankWood,MD AssistantProfessor

***Emeritus***

RoxieAlbrecht,MD TenuredProfessor

AdministrativeStaff

JessicaCapetillo Sr AdministrativeManager

LeslieMasse AdministrativeAssistant

A C U T E C A R E S U R G E R Y & B U R N S

Aftertheretirementofourlong-timetraumaleader-Dr.RoxieAlbrecht,Dr.AlisaCross has dutifully served as the interim Trauma Medical Director for our state’s only ACS VerifiedAdultLevelITraumaCenter.Sincethen,Dr.Crosshassuccessfullyledour2023 re-verificationreview,forwhichwewerecommendedforourcomplianceandqualityby the ACS. Additionally, she has begun to position our program strategically to improve ourquality,increaseeducationandoutreachinitiatives,andgrowourclinicalvolume.

Please congratulate Dr. Alisa Cross as our new Adult Trauma Medical Director. In this role, she will continue this work while collaborating with our growing core of clinical leadersandtriadpartners.

Dr Cross is a native of Tulsa, Oklahoma She graduated AOA from the OU College of Medicinein2006,completedherresidencyingeneralsurgeryatEmoryUniversityand GradyMemorialHospital,followedbyatrauma/CCfellowshipunderDr DavidFeliciano atthesameinstitution.FollowingabriefstintinPittsburgatAlleganyHealthwhereshe

servedasassociateresidencydirector,wewerefortunatetorecruithertotheDepartmentofSurgerywhereshequickly established herself with her dedication to education, interest in health systems care delivery, and clinical excellence During this time she started our surgical initiative care service line which supports the surgical care of all surgical departments and carries one of the highest case mix indices of any of our patient care units She has published and writtenchaptersaroundallfacetsofacutecaresurgeryandisactiveintheWesternTraumaAssociation.Educationally, shehasmentoreddozensofmedicalstudentsandresidentstosuccessfullyreachthenextphaseoftheirprofessional development, served nationally on the American Board of Surgery’s SCORE steering committee, and contributed to many peer reviewed trauma references and chapters. Within our state, she serves on the Oklahoma’s Trauma and Emergency Response Advisory Council and is Vice Chair of Oklahoma’s American College of Surgeons Committee on Trauma. Most importantly amongst all mentioned, she is a dedicated mother to sons Levi and Benjamin. CongratulationsDr.Crossaswelookforwardtothenextleaderintraumasurgeryinourstate!

EmilySwitzer,MD

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The OU Health Way Champion Award is a prestigious accolade that celebrates exceptionalcontributionsofourphysiciansandteammembers.

We want to celebrate those who embody the essence of the OU Health Way uphold our core values: Patients First, Relentless Excellence, Integrity, Inclu Teamwork,andLearning.

It'sanopportunityforustoacknowledgeandappreciatethosewhoplayapiv roleinfosteringaculturethatalignswithourvisionandpositivelyimpactsthe ofourpatientsandfellowteammembers

The OU Health Way Champion Award was introduced in October 2023 and received83nominations!

PhysicianOUHealthWayChampion:EmilySwitzer,M.D.

EmilySwitzer,M.D.,isatraumasurgeonatOUHealth.Hernominationsaidshedisplaysrelentlessexcellenceeachand everydaybybringingapositiveattitudeandadesiretochangeourprogramandpoliciesforthebetter.

Dr.Switzer“isconstantlyworkingonwaystoimprovepatientsafetyandhasspearheadedmanynecessarychangesin ourICUsthathavealreadyhadpositivepatientoutcomes.Sheiscollaborativeandvaluesothers’ideasonprojects.Dr. SwitzeristrulyanassettoourinstitutionandembodiesallofthevaluesoftheOUHealthWay,”thenominationread.

Congratulations,Dr.Switzer!Thankyouforallyoudoforyourpatients,team,andcommunity.You’re anoutstandingexampleoftheOUHealthWayandourcorevalues.

CITATION:

EmilySwitzer,MD

HaroldM.Burkhart,MD ProfessorandChief

DivisionofCardiac,Thoracic&VascularSurgery

PaulH.andDorisEatonTravisChair OUCollegeofMedicine|OUHealth DepartmentofSurgery

ChiefofPediatricCardiothoracicSurgery

CMRIBrandonWeedenChair Surgeon-in-Chief,OCH SurgicalDirector,CICU OkalhomaCHildren’sHosptial

AcademicFaculty

BenjaminChou,DO AssistantProfessor

JoshuaGierman,MD AssociateProfessor

BenjaminGreif,MD AssociateProfessor

ShinobuItagaki,MD AssistantProfessor

J.MatthewReinersman,MD AssociateProfessor

JessSchwartz,MD AssociateProfessor

NanaToyoda,MD AssistantProfessor

NeilVenardos,MD AssistantProfessor

AdministrativeStaff

JenniferBurks AdministrativeManager

ShellyJones AdministrativeCoordinator

NashonaRagland, AdministrativeManager PediatricCardiothoracicSurgery

C A R D I A C , T H O R A C I C & V A S C U L A R S U R G E R Y

PredictHeartValveLeakageinChildren

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Aninnovativenewfieldofresearchholdsthepromiseforpediatriccardiologistsandheartsurgeonstopredictthefuture structuralintegrityofachild’sheartvalvessotheycanperformthebestpossiblesurgerytoday.

AttheUniversityofOklahoma,apediatricheartsurgeonandcardiologistare collaboratingwithabiomedicalengineerinatypeofresearchthatfewinthenati aredoing.Byleveragingtheexpertiseand technologyoftheirrespectivefields,th arecreatingcomputationalmodelstohelpthemmorefullyunderstandthe intricaciesofindividualhearts.Whereastraditional imagingtechniqueslike echocardiogramprovideapictureoftheheartinmotion,acomputationalmodel offersasimulatedviewoftheshapeofthevalves,possibleweakspots,theblood movingthroughthevalves,andpotentialsurgicalstepstopreventfutureproblem

“Thisistrulytranslationalmedicine,”saidOUHealthpediatricheartsurgeonHaro Burkhart,MD,whoisalsoaprofessorandchiefofcardiovascularandthoracic surgeryintheOUCollegeofMedicine

“Becauseofourmultidisciplinarycollaboration,wehavetheknowledgetogetherto createacomputationalmodelthatgoesbeyondwhatweareabletoseewithboth 2Dand3Dechocardiogram.Itallowsustogoastepfurtherandvisualizetheheartasitwouldbeinreallifewiththe characteristicsofeachindividual,”Burkhartsaid.“Withthatunderstanding,wecantestwhatwouldhappenifweputa stitchhereortightenavalvethere doesitputtoomuchstressonthevalve,ordoesitaddresstheproblem?Itcan potentiallygiveusalotmoredirectionbeforeweevengointotheoperatingroom.”

Theresearchgroupbegantheirstudieswithhypoplasticleftheartsyndrome,aseverebirthdefectinwhichtheleftside ofababy’sheartdoesnotformcorrectlyandcannotpumpbloodwell,leavingtherightsideofthehearttopumpblood tothelungsandtherestofthebody.Withoutasetofthreeofopen-heartsurgeriestorepairthedefect,theconditionis often fatal. While continuing those studies, they are now developing computational models for atrioventricular canal defect, sometimes called a hole in the heart, because the baby is born with a hole in the wall separating the heart’s chambers.

While surgeries for both conditions are often successful, children sometimes face a risk of re-operation in the future becauseofleakyvalves,Burkhartsaid Inhypoplasticleftheartsyndrome,about25%ofpatientshaveleakyvalvesby thetimetheyareinpreschool Babieswithatrioventricularcanaldefectsometimesexperiencevalveleakagesixmonths totwoyearsaftertheinitialsurgicalrepair,forreasonsthatarenotyetunderstood Follow-upsurgeriesareabouthalf assuccessfulastheoriginalprocedure,andiftherepaircan’tbemade,thechildmayneedamechanicalheartvalve, whichcomeswithitsownsetofrisksandcomplications.

Duringsurgery,whentheheartisstoppedandonabypassmachine,itlaysflatanddoesn’tmaintainitsstructureasit would if it were pumping blood. Surgeons employ techniques to inflate the valves to improve their view, but heart surgeryistime-limitedandallowsfornotrialanderror.Ifacomputationalmodelcanpredictwhichareasoftheheart valvescouldbecomeproblematic,surgeonsmaybeabletotakestepstopreventthatleakageinthefuture.

HaroldBurkhart,MD

“Evenwith3Dechocardiogram,it’shardtoseethefinerdetailsofthevalves,”saidOUHealthcardiologistArshidMir, M.D.,anassociateprofessorofpediatriccardiologyintheOUCollegeofMedicine.“MostheartvalvesarelikePringle chips theyaremoreangularandhavehighandlowpoints.Wewanttolearnaboutthesevalvesandtrytopredict whichvalves,rightatbirth,wouldhaveariskofbecomingleakywhenthechildisbetween1and5yearsold,sothatwe cantrytoaddressthemsurgicallyatthetimeofthefirstrepair.

“Whatwearedoingismovingtowardpersonalizedmedic thinkabouteachpatientdifferentlyratherthanthinking disease?Whatisuniqueaboutthischild’sanatomythatm re-operations?Thisisthewaywewillbethinkingaboutt thefuture.”

BurkhartandMirworkwithChung-HaoLee,PhD,aform researchernowattheUniversityofCalifornia,Riverside modelsthatdrawfromthefieldsofphysics,fluiddynami bioengineeringtocreatesomethingthathasn’texistedbe provide2Dand3Dechocardiogramsofpatientsenrolledinthestudiesforthe calibrationofthemodelsandformodelprediction.Theywillcontinuetogatherdata frompatientsatmultipletimepointsoverthenextseveralyears.

“Through this image-based computational model, we want to provide the missing information which patients will have valve dysfunction,” Lee said. “If we can better understand which valves have weak spots and may start leaking, surgeonsmayplantheirsurgeriesdifferentlyandcardiologistsmaywanttomonitororfollowthepatientmoreclosely aftersurgery.”

Thusfar,theresearchteamhaspublishedabout10papersontheircomputationalmodelingforhypoplasticleftheart syndromeandrecentlypublishedapaperonatrioventricularcanaldefectintheAnnalsofBiomedicalEngineering. Abouttheproject

The research team’s latest paper, “Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular HeartValves,”isatTheresearchteam’slatestpaper,“BayesianOptimization-BasedInverseFiniteElementAnalysisfor AtrioventricularHeartValves,”isat

The research has been supported by the Presbyterian Health Foundation in Oklahoma City, the American Heart Association, the Oklahoma Center for the Advancement of Science and Technology, and the National Institutes of Health.

CITATION:

Multidisciplinary Research Team Creates Computational Models to Predict Heart Valve Leakage in Children (April 16, 2024). OU Medicine A bold step forward Winter 2024- 2025 Newsletter, pg 27 https://www ou edu/news/articles/2024/april/research-team-creates-computationalmodels-to-predict-heart-valve-leakage-in-children

ArshidMir,MD

forLungCancerSurgery

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OUHealthhasbecomethefirsthealthsysteminOklahomatoutilizeaninnovative newimagingagentthatcauseslungcancercellstoglowduringsurgery.Thismarksa significantadvancementinlungcancertreatmentforthestate,withthepotentialto improvesurgicaloutcomesandrecoverytimesforpatients.

Thefluorescentimagingtechnology,calledCytalux,bindstocanceroustissuewhen administered prior to surgery, making it easier for surgeons to completely remove tumorswhilesparinghealthytissue.

"This technology allows us to visualize cancer that might otherwise be difficult to detect. For lung cancer patients, it means we can perform less invasive surgerie with more precision, potentially leading to faster recoveries and better outcomes, said thoracic surgeon Dr. J. Matthew Reinersman, M.D., FACS, Chief of Section o Thoracic and Foregut Surgery in the Department of Surgery at the University of OklahomaCollegeofMedicine

MatthewJ Reinersman,MD

A69-year-oldpatient,whohadasmalllungnodulediscoveredduringimagingforashoulderinjury,underwentthe proceduresuccessfullyinSeptember2024."Histumorwascompletelyremovedwithnegativemargins,andnolymph nodeswereinvolved Heiscancer-freeandwillnotrequireanyothertreatmentsuchaschemotherapyorradiation," Dr Reinersmansaid

Morethan130,000Americansdieoflungcancereachyear,makingittheleadingcauseofcancerdeathintheUnited States. Lung cancer is often diagnosed late, when it has already begun to spread. In Oklahoma, more than 3,200 people are diagnosed with lung cancer each year, and nearly 16% of those patients will undergo surgery as a first courseoftreatment,accordingtotheAmericanLungAssociation.

"Thistechnologynotonlyhelpsuswithprimarylungcancersbutalsowithidentifyingspreadofcancerfromother sitestothelung,"Dr.Reinersmanadded."It'sagame-changerforhowweapproachcertaincancersurgeries."

On Target Laboratories, Inc., a privately held biotechnology company based in West Lafayette, Indiana received approvalforCytaluxinNovember2021byTheU.S.FoodandDrugAdministration(FDA)foruseinadultpatientswith ovarian cancer. In December 2022, the FDA expanded its approval to include use in adult patients with known or suspectedlungcancer.

CITATION: OUHealth 14Nov2024,https://wwwouhealthcom/blog/2024/november/ou-health-surgeons-first-in-oklahoma-to-use-glow/ #~ce56ae54-eaa4-4ba0-9077-6aeccd154a2b

CatherineJ.Hunter,MD,FAAP,FACS

ProfessorofSurgery

ChiefofPediatricSurgery

ProgramDirectorofPediatricSurgery

EdithKinneyGaylordPresidentialProfessor

PaulaMilburnMillerChairinPediatric Surgery

OklahomaChilren’sHospital

OUCollegeofMedicine|OUHealth DepartmentofSurgery

AcademicFaculty

CatherineHunter,MD Professor/SectionChief

JeremyJohnson,MD AssociateProfessor

AlessandraLandmann,MD AssistantProfessor

PaulMcGaha,MD AssistantProfessor

AdministrativeStaff

SusanCloer Finance/Administrative Coordinator

P E D I A T R I C S U R G E R Y

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Inthepastyear,threeresearchersattheUniversityofOklahomaCollegeofMedicine at OU Health Sciences have earned more than $5 million in grant money to study causes and potential treatments for necrotizing enterocolitis, a deadly intestinal diseasethatprimarilyaffectsinfantsbornprematurely BecauseNECoccurssuddenly andprogressesrapidly,researchiscrucialforgivingthemostfragilebabiesachance atlife.

About7%ofallpretermbabiesarediagnosedwithNEC,whichoccurswhenthe baby’sunderdevelopedsmallintestineshaveanexcessivereactiontonaturally changingbacteria.UnlessNECcanbestopped,theliningoftheintestinalwall becomesnflamed,andtheintestinescanruptureordie.Inabout30%ofcases, theinfantdies,oftenhoursordaysafterdiagnosis.Forpretermbabieswhoare bornweighing2poundsorless,theriskofdeathwithNECisashighas50%.The babieswhosurviveoftenfaceproblemswithgrowth,nutrition,walkingand cognitivedevelopment.ThegrowingNECresearchprogramattheOUCollegeof MedicineistacklingNECfrommultipleangles.

“ThisisanexcitingtimeforNECresearchintheOUCollegeofMedicinebecauseweareincreasing thenumberofinvestigatorsfocusedonthedisease,andourprojectsrepresentseveraldisciplines in pediatrics,” said Hala Chaaban, M.D., director of clinical and translational research in the college’sDepartmentofPediatrics,Sectionof Neonatal-PerinatalMedicine.

Chaaban,aneonatologist,isoneofthethreeresearchersintheOUCollegeofMedicinewho recentlyearnedlocal,stateandfederalfundingtostudyNEC Theothertwoarepediatricsurgeon CatherineHunter,MD,SectionChiefofPediatricSurgery,andscientistKathrynBurge,PhD, intheSectionofNeonatal-PerinatalMedicine.Eachleveragesheruniquevantagepointinavariety ofinnovativeresearchprojects.

CreatineSupplementation

Burge’slatestgrantsfundherfocusoncreatine.Thisnaturalcompoundisknownforitsability tostrengthentheintestinalbarriersothatbacteriacan’tcrossiteasily,aswellasforsupplying energytointestinalcells.Becausecreatineaccumulatesinthefetusduringthethirdtrimester ofpregnancy,babiesbornprematurelydon’treceiveenoughofthenutrientfromtheirmothers. Andinfantsarenotabletoreplenishtheirsupply,eventhoughcreatineispresentinbreastmilk inlowlevels.Inherlaboratory,Burgeistestingtissuestodeterminewhethercreatinelevelsare lowordropsuddenlybeforeNECdevelops.

“We will also be treating our cell-based models with creatine to see whether they are more resilienttoNEC,”Burgesaid “NECdoesn’tusuallyaffectbabiesrightafterbirth;itoccursseveral weeks later So, we are studying the possibility of supplementing with creatine in the window before NEC develops Can we give creatine and build it up to the level it should have been and thereforepreventNEC?”

CatherineHunter,MD

HalaChaaban,MD

KathrynBurge,PhD

Burge’s research is funded by the National Institutes of Health and the Oklahoma City-based Presbyterian Health Foundation.HernewestNIHgrantestablishesherasanindependentresearcher.

ProtectingtheBarrier

Asapediatricsurgeon,Huntermayremovedeadportionsoftheintestineifantibioticsandnutritionfailtohelpababy withNEC.Surgeryistricky shemustdeterminethebesttimetooperatetopreserveasmuchintestineasshecan,yet notperformunnecessarysurgeriesonsmallandfragilebabies.

“Unfortunately, many babies with NEC require surgery, and after surgery, mortality rates are very high. If they do survive,theirchancesofneedinganintestinaltransplantdowntheroadarehigh,andthatisnotideal,”Huntersaid.“As ascientist,IwanttodevelopstrategiestopreventNEC.I’dratherbabiesnotevergettothepointwheretheyneedme asasurgeon.”

Hunter’sresearchcentersontheintestinalbarrier,whichkeepsbacteriafromenteringthebloodstream Inparticular, sheisstudyingaspecificsignalingpathwaycalledROCKthatactslikeazippertokeeptheintestinalbarrierstrong In thedevelopmentofNEC,somethinghappensintheROCKpathwaytoweakentheintestinalbarrier

“In our lab, we have discovered that ROCK is activated during the development of NEC and that inhibiting ROCK appears to protect some of the intestinal barrier function,” Hunter said. “This new grant will allow us to continue studyingthispathwaytobetterunderstanditspotentialinpreventingNEC.NoteveryprematurebabydevelopsNEC, butthisresearchmayhelpusbetterunderstandwhysomearemoresusceptibletothecondition.”

HunterhasreceivedfundingfromtheNIHandtheOklahomaCenterforAdultStemCellResearch.Sheisamongasmall groupofsurgeonsnationwidetoreceiveanNIHR01grant,consideredthegoldstandardinresearchfunding.

HyaluronicAcidandProteins

One of Chaaban’s longtime research areas is hyaluronic acid in human breast milk, which is beneficial for the development of a baby’s intestines. Because preterm babies begin their lives with underdeveloped intestines, they don’treceivethesamebenefitsfromhyaluronicacidastermbabiesdo Chaaban’sresearchhasshownthatadditional doses of hyaluronic acid in mice help the intestines mature more rapidly and protect from intestinal injury like NEC wouldcause

Chaaban’snewR01grantfromtheNIHwillallowhertocontinuestudyingtheroleofhyaluronicacidinhumanbreast milkandwhethersupplementationinpretermbabiesmightonedaybepossibletopreventNEC.

An additional research focus, funded by a subcontract through the federal government’s Small Business Innovation Researchprogram,isagroupofproteinsmadeinthebodycalledinter-alphainhibitorproteins,orIAIP,whichprotect againstinflammation.BabieswithNEChavelowerlevelsofIAIP,puttingthematriskforproblems.Chaabanistesting whethergivingadditionalIALPreducesinflammationandthechanceofmulti-organfailureinmouseresearchmodels.

“IAIPappearstocalmdownthebody,”shesaid.“InbabieswithNEC,theirbodiesaretryingtoprotectthemselves,but theyarenotmatureenoughtodifferentiatebetweenwhatisbadandwhatisgood,sotheirimmunesystembasically killsallthecells,andtheirorgansbegintofail.GivingIAIPappearstobeawaytoquietdownthebody’sinflammation.”

Chaaban and fellow OU College of Medicine neonatologist Birju Shah, MD, are working with a company called ProThera Biologics to test a rapid diagnostic tool that can be used at the bedside to measure levels of IAIP Results would be available within 10 minutes, allowing doctors to act quickly. After Phase 1 and 2 clinical trials testing the device,itappearspromising.

Because Oklahoma Children’s Hospital OU Health offers the highest level of neonatal intensive care and around-theclock surgical coverage, it treats most babies in the state with NEC. Complementing that expertise with research will improvethecarethatbabiesreceive.

“Ilovetakingcareofpatientsandfamiliesandhavingthoseindividualrelationships,”Huntersaid,“butsciencegivesus theopportunitytohaveawiderimpactandmaybeevenmakeapositivechangeforanentirepopulationofpatients. Researchisincrediblyimportant.”

CITATION:

OU College of Medicine Researchers Earn Over $5 Million to Study Deadly Disease That Affects Premature Babies (2024, January). https:// www ouhsc edu/news/details/ou-college-of-medicine-researchers-earn-over-5-million-to-study-deadly-disease-that-affects-prematurebabies

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WhenVivianBodenhamerwasbornfull-termin2014,herparentshadnoideaofthemedicaljourneyahead Atjust6 weeksold,Vivianwasn’teatinglikeatypicalinfant Hermother,MirandaBodenhamerofNorman,noticedsomething wasn'tright

"Shewasvomitingwhenevershewouldeat,like,projectilevomiting,"Mirandasaid."Iwouldbebreastfeedingher,and shewouldvomit,anditwouldhitthewallbehindme.Ihadthreeotherkids,threeolderboys,andnoneofthemdid that,soIreallyknewsomethingwasnotright.”

Afterinitialtestsatalocalhospital,VivianwasquicklytransferredtoOklahomaChildren'sHospitalOUHealthformore complex tests. Doctors discovered she had a severe urinary tract infection (UTI) and neurogenic bladder, a condition wherethebladderdoesn'temptyproperly.

Butthevomitingpersisted,leadingdoctorstosuspectabowelobstruction.Herdoctors,Dr.M.AdnanAltaf,M.D.,FAAP,a pediatricgastroenterologistwithOklahomaChildren'sHospitalandChiefoftheDivisionofPediatricGastroenterology, HepatologyandNutritionattheUniversityofOklahomaCollegeofMedicine,andDr.JeremyJohnson,M.D.,apediatric surgeon at Oklahoma Children's Hospital and Associate Professor in the Department of Surgery at the OU College of Medicine,foundnophysicalobstruction

"Theywerelike,‘She'samedicalmystery,'"Mirandasaid

RareDiagnosis:ChronicIntestinalPseudo-Obstruction

Afterweeksoftestingandobservation,VivianwasdiagnosedinOctober2014 withchronicintestinalpseudo-obstruction.Thiscomplexdisorderaffectsthe movementoffoodthroughthedigestivesystem,mimickingthesymptomsofa physicalobstructionwithoutanyactualblockage.Intestinalpseudo-obstruction presentsuniquechallengesindiagnosisandtreatment,aseachcasecanvary significantly.

"Basically,theentireGItractdoesn'tworkforprocessingfood.Normally,your stomachandintestinessqueezeinacoordinatedwaysothatfoodgoesthrough, andyoudigestit,”Dr.Johnsonsaid.“Butforher,itdoesnothappen,which preventsherfrombeingabletoeat."

JeremyJohnson,MD

To ensure Vivian received proper nutrition, her care team at Oklahoma Children's Hospital implemented a crucial intervention "The only way for her to grow and get nutrition was IV nutrition, so she had to have a special catheter placedtoreceiveIVnutritionathome,"Dr Johnsonsaid

ThismethodofnutritionhasbeenaconstantinVivian'slifesinceinfancy.Overtheyears,Vivian'scaserequiredmultiple interventionsandcarefulmanagement.InJanuary2023,Vivian'sconditionworsened,andsheunderwentasignificant surgicalinterventionintheformofadivertingileostomy.

"Thinkoftheintestinesaslikeagardenhosethatgoesfromoneendtotheother,”saidDr.Johnson.“Whenyoumake anostomy,youcutthatgardenhoseinhalfandbringtheendthatwaterisflowingthrough–inthiscase,it'swaste–up totheskin,throughtheabdominalwall.Thebagisjusttheretocatchit,soyoudon'tmakeamess."

Four days after the surgery, however, Vivian’s bowel perforated, and she went septic. Dr. Johnson came in on his weekend off to do the surgery She stayed for three weeks in the ICU while her health team remained unwaveringly involvedinherrecovery

"TheICUdoctorswereamazing Dr JohnsonwouldcomebyandcheckonusasdidDr Atlafandeverybody,"Miranda said.Despitethesechallenges,Vivianapproacheslifewithremarkablespirit.

"She's just your typical 10-year-old," Miranda said. "She does ballet, and she does virtual school. She has three older brothersandgivesthemheck."

Vivianreferstohermedicaldevicesasher"accessories,"andherresilienceallowsherandherfamilytoenjoylife,even takingacruisetoHondurasandMexicorecently.Hervivaciousnatureimpressesherdoctorsaswell.

"She doesn't really have any limitations,” said Dr. Johnson. “She can still be whatever she wants to be. I think she’s amazingbecauseshekeepssuchapositiveattitudeandhasanamazingsenseofhumorthatmakeseverythingeasier. TheImportanceofSpecializedCare

Dr AtlafemphasizestheuniquenatureofVivian'scase,notingthatthecomplexityofherconditionrequiresconstant reevaluationandpersonalizedcare WhileVivian'sconditionpresentsongoingchallenges,herfamilyremainshopeful "It'samultidisciplinarydisorderthatneedsmultidisciplinarymanagementwiththeinvolvementofvariousspecialists, includingsurgeons,urologists,radiologists,andGIspecialists,”saidDr Atlaf “OklahomaChildren'sHospitalstandsout asoneofthefewcentersequippedtohandlesuchcomplexcases.”

Fornow,ViviancontinuestothrivewiththesupportofherfamilyandtheOklahomaChildren’sHospitalteam. "She'sspunkyandspicyandsassy,"Mirandasaysproudly."Ifyousawheronthestreet,youwouldn'tknowanything waswrongwithher."

FromspecializedGIcaretodedicatedICUteams,OklahomaChildren’sHospitalhandlescomplex,long-termpediatric caseswithexpertiseandcompassion.FortheBodenhamerfamily,theshort30-minutedrivefromNormanmadeseeing thespecialistseveneasier.

"EverybodyatChildren'sissoamazing,"Mirandasaid."Whenyou'rethereforsixweeks,yougettoknowthenurses, and you develop relationships that are just super special. One of the nurses even named her new baby Viviana after Vivian.YoujustgetsoclosetoallthedoctorsandnursesatOklahomaChildren’sHospital."

CITATION:

Vivian’s Gastrointestinal Issues Don’t Slow Her Down Thanks to Complex, Ongoing Care. (2024, November). https://www.ouhealth.com/ blog/2024/november/no-limitations-vivian-s-gi-issues-don-t-slow-her/# ce56ae54-eaa4-4ba0-9077-6aeccd154a2b

SuhairMaqusi,MD,MSs AssociateProfessorofSurgery SectionChiefofPlasticand ReconstructiveSurgery

Plastic&ReconstructiveSurgery FellowshipDirector

OUCollegeofMedicine|OUHealth DepartmentofSurgery

AcademicFaculty

GuilhermeBarreiro,MD AssistantProfessor

ChristianElAmm,MD Professor

MarkMims,MD AssistantProfessor

AdministrativeStaff

MagaliOchoa AdministrativeAssistant

P L A S T I C & R E C O N S T R U C T I V E S U R G E R Y

OUHealthHelpsWomanRecoverAfterExplosiveCrash

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A Blanchard couple, Joey and Dustin Pettijohn, are recovering at home after a distracted driver hit their Jeep, causing severeburnsthatrequiredmultiplesurgeriesandamonth-longhospitalstay.JoeyPettijohnwastreatedbytheskilled team at OU Health, including plastic surgeon Dr. Guilherme Barreiro, M.D., and trauma burn coordinator Denni WilsonLowber,whohavebeeninstrumentalinherrecovery,addressingboththephysicalandpsychologicaltollofherinjuries. Despite the severity of her burns, Joey is grateful to be alive and is slowly resuming normal activities, cherishing momentswithherhusbandandfamily.

PlasticsurgeonsatOUHealthworkonsomeofthemostpainfulandd Theystrivetorestoresomeaspectsofnormalcytopatients’liveswhile senseofhope

Aroutineaction,likeawalkintheparkwiththegrandkids,canfeellik severalweeksinsideahospital JoeyPettijohnandherhusbandDusti momentandeveryrayofsunlightbecauseeverythingnearlywentdar

“It’sverynicetogetout,”saidJoeyPettijohn,walkingwithherfamilya Blanchard. LastMay,nearBlanchard,adistracteddriverhitPettijohn’ exploded.

“Wehadsloweddowntoturn,andsomekidjustwasn’tpayingattenti said. Fewwordscandescribetheirinjuries.ThePettijohn’swereleftwiththird-degree burnsthatrequiredseveralsurgeriesandaboutamonthinthehospital.

“That’stheworstpart–theafter,”DustinPettijohnsaid.OUHealthtraumaburncoordinatorDenniWilson-Lowber'steam treats complex injuries. “Probably the most painful thing you would endure,” Wilson-Lowber said. Joey Pettijohn’s injurieslandedheratOUHealth–alevelonetraumacenter–wherePlasticSurgeonDr GuilhermeBarreirowenttowork

“Theresponsibilityissomethingthatactuallytouchesyou,”Barreirosaid “Youfeellikeyouaregivingback”

Thesedoctorsandnurseshelphealthebodyandthemind.Wilson-Lowbersaidthepsychologicaltollfromburninjuries can be just as detrimental to a patient. “It’s very emotional,” Wilson-Lowber said. Their efforts brought the Pettijohn familybacktogether. “We’velearnedhowtohelpeachotherout,”Pettijohnsaid. Lifemovesslower,butthey’regrateful they’relivinglifeagain.Pettijohnrefusedtoliveinfearso,sheboughtanotherJeep.

“If you ride a horse and you fall off, you get right back on,” she said. “We’re gonna keep going.” Pettijohn said she has shiftedherperspectivesoshecouldseethemiraclesallaroundher.“Don’ttakethingsforgranted,”Pettijohnsaid.

ThePettijohnshavealongrecoveryaheadwiththeseverityoftheirinjuries,buttheyhavehealedthewaydoctorshoped sofar.Pettijohnsaidsheencouragesotherdriverstobemindfulontheroadandpayattention.

CITATION:

9News, Jordan Fremstad, OU Health Burn Unit Helps Blanchard Couple Recover After Explosive Crash (2024, July) https://www.news9.com/story/66a0fa920eabe0b734e6fe42/ou-health-burn-unit-helps-blanchard-couple-recover-after-explosive-crash

GuilhermeBarreiro,MD

-StoryprovidedbyOUHealth|OUDivisionofMarketingandCommunications

OU Health recently welcomed its fourth cohort of Ukrainian physicia week surgical training program. The program aims to equip these ph advancedtechniquestotreatseverewar-relatedinjuries,particularlyt the head and neck. Led by Mark Mims, M.D., the program has expand neurosurgeonsandaneurologist.Thevisitingphysicianssharedthech faceinUkraineduetowar-relatedinjuries,andtheinitiativeaimsto expertiseandprovideunwaveringsupport.

Duringtheprogram,theUkrainiansurgeonsobservedandrefinedthe the guidance of OU Health’s expert team. An important aspect of involved using technologically advanced glasses donated by Ohana allowU.S.-basedphysiciansto"see"intotheoperatingroomswiththe they return to Ukraine This innovative approach enables remote a collaborationbetweenthesurgeons

MarkMims,MD

Dubbed"OperationUkraine,"thisprogramispartofOUHealth'songoingcollaborationwiththeAmericanAcademyof Facial Plastic and Reconstructive Surgery It is supported by organizations such as Razom for Ukraine, INGenuis, and SoonerHopeforUkraine Theprogramaimstoenhancemedicalknowledgeandskillsthroughinternationalexchange andcontinuestohaveasignificantimpactonmedicalcareinUkraine.

"MultipleroundsofsurgeonshavecometoOUHealthatregularintervals.Thisisourfourthgrouptovisit,andweaimto ensuretheavailabilityoftheseadvancedtechniquesacrossUkraineandcontributetothedevelopmentofasustainable modelofcareforheadandnecktrauma."

CITATION: Fourth Cohort of Ukrainian Physicians Visit Oklahoma to Train at OU Health (2024, October) https://hub.ouhealth.com/ce/pulse/user/content/search? search page=beta search home page&keyword=mark+mims&isSearchFullNetwork=true

AjayJain,MD,FACS

ProfessorandChief,DivisionofSurgicalOncology

TheG.RaineyWilliamsChairinSurgicalResearch ProgramDirector,GeneralSurgicalResidency OklahomaStateChair

AmericanCollegeofSurgeonsCommissiononCancer OUCollegeofMedicine|OUHealthDepartmentof Surgery DepartmentofSurgery

AcademicFaculty

KristinaBooth,MD AssociateProfessor

StevenCarter,MD AssistantProfessor

JuanClaros-Sorto,MD AssistantProfessor

FernandoMier,MD AssistantProfessor

AlexanderRaines,MD AssociateProfessor

TeresaShavney,MD AssistantProfessor

BarishEdil,MD Professor ***Emeritus*** RonaldSquires,MD TenuredProfessor

AdministrativeStaff

JessicaCapetillo Sr.AdministrativeManager

LeslieMasse AdministrativeAssistant

BrookeTheriault AdministrativeAssistant

S U R G I C A L O N C O L O G Y

FirstLiverTransplantforAggressiveCancerAchievedatOUHealth

OU Health Becomes Only Center in Oklahoma to Offer Liver Transplants for Bile Duct Cancer -StoryprovidedbyOUHealth|OUDivisionofMarketingandCommunications

In May, experts at OU Health completed the state's first liver transplant for a particularly challenging and oftentimes deadlyformofabileductcancerknownascholangiocarcinoma.ThisachievementnotonlyplacesOUHealthamong thefeweliteprogramsinthecountrythattreatbileductcancerswithtransplantation,butalsobringsimmensereliefto Oklahomanswhonolongermustleavethestatetoreceivelife-savingtreatment.

BeforethefirsttransplantatOUHealth,patientstraveledtocentersseveralhundred milesawayforatransplanttoaddresshilarcholangiocarcinoma.Hilar cholangiocarcinoma–bileductcancerthatoccurswheretheductsexittheliver–isone ofthemostlethalcancersandamongthehardesttotreat.Theoverallfive-yearsurvival forthosediagnosedwiththisdiseaseislessthan10%.Historically,theonlychanceata cureistosurgicallyremovepartoftheorgan.

Only20to30%ofpatientsareeligibleforasurgicaloptionduetohowaggressiveand advancedthecancercanbeatthetimeofdiagnosis Forthefewpatientswhoare candidatesforsurgery,thecomplexoperationrequiresremovingupto70%oftheliver, resultinginahighriskofmorbidityandmortality Theprocedureisonlyperformedata fewhigh-volumecenterswithexpertiseandresourcesforcomplexhepatobiliarysurgery, whichnowincludesOUHealth.

ThepatientatOUHealthwasfirsttreatedwithacomplexregimenofpreoperativechemotherapyandradiation,saidOU Health Stephenson Cancer Center surgical oncologist Dr. Ajay Jain M.D., FACS, core medical director for Stephenson CancerCenterandprofessorofsurgeryandchiefoftheDivisionofSurgicalOncologyintheDepartmentofSurgeryat TheUniversityofOklahomaCollegeofMedicine.Dr.JainalsoservesasOklahomaStateChairfortheAmericanCollege ofSurgeonsCommissiononCancer.

However,Dr.JainrecognizedthatalivertransplantwouldofferthehighestchanceofsuccessandthankstoOUHealth's ability to perform a liver transplant for this complicated disease, the patient now has a higher chance of long-term survival.

TheMostChallengingofAllCancers

Cholangiocarcinoma is a type of cancer affecting the bile ducts carrying the digestive fluid bile from the liver to the gallbladderandsmallintestine Ittypicallyoccursinindividualsovertheageof50,thoughitcanoccuratanyage

Because of its aggressive nature, cholangiocarcinoma is often diagnosed when the cancer is advanced, making successfultreatmentdifficulttoachieve.

“Only 20 to 30% of patients with this cancer will be able to receive surgical treatment options because the disease is silent,andwhenitgetsdiagnosed,mostpatientswillbeatanadvancedstatewheresurgicalresectionsortransplants are not possible,” said OU Health Transplant Institute surgeon Dr. Narendra Reddy Battula, MBBS, MRCS, M.D., FRCS, assistantprofessorintheDivisionofTransplantSurgeryintheDepartmentofSurgeryatOUCollegeofMedicine.

AjayJain,MD

The transplant technique for bile duct cancers differs from liver transplant done for liver failure or liver cell-based cancer.Whenwedoroutinelivertransplants,wedisconnectthebileducts.Butwhenwetreatbileductcancer,weneed todoanextensiveremovalofthebileduct,whichjoinsthelivertothebowelsnearthepancreas.Wemustmakesureno cancerhasspreadbeyondtheliver.”

Inthelate1990s,MayoClinicbeganthefirstclinicaltrialstoassesstheuseoflivertransplantationasatreatmentfor hilar cholangiocarcinoma. Over several years and multiple clinical trials, data has shown that patients who undergo successful transplants have five-year survival rates of 65 to 68%, and 10-year survival rates reaching up to 60%. This marksasignificantimprovementcomparedtotheusual10%five-yearsurvivalrateassociatedwiththediagnosis.

Despitetheimprovedsurvivalrates,onlyroughly20programsinthecountryoffer transplantationforcholangiocarcinoma Thislimitationstemsfromthedemanding natureoftheprocedurewhichrequiresspecialized,multidisciplinaryexpertisefrom variousfields,includinginterventionalradiology,advancedgastrointestinal,medical oncology,radiationoncology,hepatobiliarysurgery,transplantsurgery,andtransplan medicine,tonameafew.

OUHealthMakesHistoryinOklahoma

“OUHealthnowperformsmorethan50traditionallivertransplantsayear,and becauseoftheexpertiseatStephensonCancerCenterandouroutstandingtransplant programatOUHealthalreadydoingsomeofthemostcomplicatedtransplantsinthe country,wefeltwecouldstartdoinglivertransplantsforcholangiocarcinoma,”said Dr.Jain.“Thistransplantwasthefirstoneofitskinddoneinthestate.”

NarendraBattula,MD

Dr. Battula and his colleague, transplant surgeon Dr. Maheswaran Pitchaimuthu, MBBS, MRCS (Edin.), FRCS (Eng.), assistant professor in the Division of Transplant Surgery in the Department of Surgery at OU College of Medicine, worked alongside a team of medical oncologists, radiation oncologists and transplant hepatologists to implement diagnostic,chemotherapyandradiationprotocolsneededforthisinnovativetreatment

OtherkeymedicalprofessionsincludedStephensonCancerCenteroncologistsDr HassanHatoum,MD,Dr RyanNipp, MD,MPH,andDr SusannaUlahannan,MD,MMed,aswellasradiationoncologistsDr AndreaJohnston,MD,andDr Christopher Bozarth, M.D.; advanced endoscopy specialist Dr. Amir Rumman, M.D., and transplant hepatologists Dr. AbdulM.Oseini,M.D.,MScandDr.SidraAhsan,M.D.

“All these patients were being referred to other centers out of state to be considered for transplant, and we had to question ourselves as to why we weren’t offering this,” Dr. Battula said. “We have an amazing cancer center and an amazing transplant center here. It’s a huge emotional burden for the patient and their families to be far away in an unfamiliar environment. We have all the components, and now we are the only center in the state who can offer this typeoflivertransplant.”

CITATION:

First Liver Transplant for Aggressive Cancer Achieved at OU Health (2024, November) https://www ouhealth com/blog/2024/june/firstevidence-based-liver-transplant-for-aggres/#~ce56ae54-eaa4-4ba0-9077-6aeccd154a2b

-StoryprovidedbyOUHealth|OUDivisionofMarketingandCommunications

OUHealthStephensonCancerCenterattheUniversityofOklahomaHealthSciences has earned a three-year accreditation from the National Accreditation Program for RectalCancer(NAPRC),makingittheonlyaccreditedprograminOklahomaandone of only three other accredited programs within a 500-mile radius to receive the accreditationfromthequalityprogramoftheAmericanCollegeofSurgeons.

NAPRCaccreditationreinforcesOUHealth’scommitmenttoexcellenceinrectalcancer care. Treatment approaches will align with the latest evidence-based care and best practices. Patients treated at NAPRC- accredited centers can expect improved outcomes,includinghighersurvivalratesandbetterpreservationofbodilyfunction.

“The NAPRC accreditation is a monumental win for Oklahoma,” said OU Health surgicaloncologist,BarishEdil,M.D.FACS,professorandChairoftheDepartmentof SurgeryattheOUCollegeofMedicineattheUniversityofOklahomaHealthSciences

“With this accreditation we can continue to provide world-class treatment for Oklahomans with rectal cancer, while furthering research, and care options I am proud of what we are accomplishing as a patient-centered, multidisciplinary cancer team”

ToachieveNAPRCaccreditation,arectalcancercentermustdemonstratecompliance with the NAPRC standards addressing program management, clinical services, and qualityimprovementforpatients.Centersarerequiredtoestablishamultidisciplinary rectal cancer team that includes clinical representatives from surgery, pathology, radiology,radiationoncology,andmedicaloncology.Onlytheprogramscommittedto providing the best care possible to patients with rectal cancer are granted accreditationbytheNAPRC.

Additionally, the team demonstrated an adherence to standards addressing clinical servicessetfortherectalcancerprogram.Thisaccomplishmentensuresthatpatients receive consistent and high-quality care, including essential clinical services such as Carcinoembryonic Antigen (CEA) testing, Magnetic Resonance Imaging (MRI), and Computerized Tomography (CT) imaging for accurate cancer staging Importantly, patients can start their treatment within a defined timeframe, leading to better outcomesandimprovedwell-being CenterofExcellenceforRectalCancerAccreditationEarnedbyOUHealth

StevenCarter,MD

KristinaBooth,MD

“Thisisamajorachievementforourorganization,”saidOUHealthsurgicaloncologist,AjayJain,MD FACS,professorand DivisionChiefofSurgicalOncologyattheOUCollegeofMedicineattheUniversityofOklahomaHealthSciences “This achievementistheculminationofmorethanfiveyearsofeffortthatstartedinJuly2019 Membersoftheprogramputin tremendoustimeandefforttooptimizequality,communication,andrapidcareforrectalcancerpatientsasmandatedby over 20 rigorous NAPRC standards. This even included photo documentation of all rectal cancer specimens in order to ensureadequatesurgicaltechniquewasappliedandthemesorectalexcisionwascomplete.”

TheNAPRCaccreditationisarecognitionofStephensonCancerCenter’scommitmenttoprovidinghigh-quality,patientcentric, and multidisciplinary approach to care. As the state’s only NCI-designated Cancer Center, the accreditation underscoresthecommitmentofStephensonCancerCenterasthelargestandmostcomprehensiveoncologypracticein Oklahoma,highlightingthecollaborativeeffortsofspecialistsfromvariousfieldsundertheoneroof.

“Rectalcancerisuniquelychallengingtotreatduetoitslocation,”saidOUHealthcolonandrectalcancersurgeon,Steven N. Carter, M.D., FACS, FASCRS, Rectal Cancer Center Program Director. “Adherence to proper surgical techniques has shown a 75% decrease in local cancer recurrence. OU Health has policies and procedures to continually evaluate our performanceandtoensurethebestpossibleoutcomesforpatientswithrectalcancer.Itrequiresateameffort,andthis designationwithitsstandardsensureswearegivingOklahomansthecaretheydeserve.”

InOklahoma,colonandrectalcancersare19%higherthanthenationalaverage TheAmericanCancerSocietyreports that the number of people getting diagnosed with colon cancer has doubled since 1995, yet, more than one in three Oklahoma adults ages 50 and older are not getting tested as recommended Screening for colon and rectal cancers should start at 45-years-old. Statistics show that 90% percent of all individuals diagnosed with colorectal cancer, at an earlyorlocalstage,arestillalivefiveyearslater.OUHealthsurgeonsofferpatientsthebestchancetoavoidstomas,cure stage4disease,andgetbacktowhattheyenjoymost.

CITATION: Center of Excellence for Rectal Cancer Accreditation Earned by OU Health Stephenson Cancer Center (2024, February) https:// www.ouhealth.com/blog/2024/february/center-of-excellence-for-rectal-cancer-accredita/#~ce56ae54-eaa4-4ba0-9077-6aeccd154a2b

NarendraR.Battula,MD,FRCS AssociateProfessor

SectionChiefofTransplant

DirectorOUHealthTransplantInstitute TransplantSurgeon

OUCollegeofMedicine|OUHealth DepartmentofSurgery

AcademicFaculty

Surgeons

PauloMartins,MD AssistantProfessor

MaheswaranPitchaimuthu,MD AssistantProfessor

Hepatologist

JasonCheng,MD AssistantProfessor

AbdulOseini,MD AssistantProfessor

HarlanWright,MD AssistantProfessor

Nephrologist

AhmedQudaih,MD AssistantProfessor

MuhammedPanezai,MD AssistantProfessor

ElzbietaRybicka,MD AssistantProfessor

AdministrativeStaff

AmandaGillum AdministrativeAssistant

T R A N S P L A N T S U R G E R Y

Message from Dr. Jain

~OU

DearAll:

Health Joins an Elite Group of Cancer Transplant Programs - First Liver Bile Duct Cancer in Oklahoma~

ItismyhonorandpleasuretoannounceamajormilestonefortheTransplantDivisionintheDepartmentofSurgery,the multidisciplinaryGIoncologyprogramsattheStephensonCancerCenter,andthecitizensofOklahoma.Thetransplant programrecentlycompletedthefirsteverlivertransplantforcholangiocarcinomainthestate.Thismeansourtransplant oncology program has entered the ranks of a few elite programs in the country that treat bile duct cancers with transplantation.

Hilarcholangiocarcinoma(bileductcancerthatoccurswheretheductsexittheliver)isoneofthemostlethalcancers, and amongst the hardest to treat. Overall 5 year survival for those diagnosed with this disease is less than 10%. Historically, surgical resection offers the only chance of cure, but only 30% of patients are even eligible for surgery becausethediseaseisusuallytooadvancedatthetimeofdiagnosis Forthefewpatientswhoarecandidatesforsurgery, thecomplexoperationrequiresremoving75%oftheliver Itcarriesahighriskofmorbidityandmortality Theprocedure isonlydoneatafew,highvolumecenterswithexpertiseandresourcesforcomplexhepatobiliarysurgery,includingOU. Eveninpatientswhoundergosuccessfulsurgerytoremovethecancer,5yearsurvivalisonlyaround30%.Noneofthe patientsIhaveoperatedoninthe17yearsIhavepracticedhavebeenlongtermsurvivors.

Inthelate1990s,Mayoclinicbeganthefirstclinicaltrialstoassesstheuseoflivertransplantationasatreatmentforhilar cholangiocarcinoma Over several years and a series of clinical trials, resultant data show that patients who are successfully transplanted have five year survival rates of 65-68%, and 10 year survival rates of up to 60% This was a miraculousadvance.However,only20programsinthecountryoffertransplantationforcholangiocarcinoma.Thereason is that cholangiocarcinoma transplant requires specialized, highly-skilled, multidisciplinary expertise (interventional radiology,advancedGI,medicaloncology,radiationoncology,hepatobiliarysurgery,transplantsurgery,andtransplant medicine,tonameafew).

Overthelastfewyears,ourtransplantsurgeryprogram,comprisedofourcurrentProgramLeader,Dr NarendraBattula, andhiscolleagueDr.MaheswaranPitchaimuthu,hasbecomeafixtureintheSCCGImultidisciplinarytumorboard.They and the medical oncologists (Drs. Hatoum, Nipp, George, and Ulahannan), radiation oncologists (Drs. Johnson and Bozarth), and transplant hepatologists (Drs. Oseini and Ahsan) worked together to implement the perioperative diagnostic,chemotherapy,andradiationprotocolsneededforthiscuttingedgetreatment.Beforethisfirsttransplantat OU,thesepatientswouldneedtoleavethestateofOklahomatocentersseveralhundredmilesaway.

Ourpatientreceivedacomplexregimenofpreoperativechemotherapyandradiation,followedbyalivertransplant Final pathology in the removed liver showed that the tumor showed near complete regression after the preoperative chemotherapy and radiation. Based on the data we have, the patient should have a favorable prognosis with a 60% chanceoflongtermsurvival.

WhenIarrivedherein2019,theprogramwasaveragingonlyonelivertransplantperyear.SinceDr.Edilintegratedthe transplantsurgeryprogramintotheDepartmentofSurgerywithnewfacultyandleadershipin2021,thevolumeshave increased tremendously. In 2023, Drs. Battula and Pitchaimuthu set the all-time annual record, completing 53 liver transplants.Thisexpertiseandvolumeallowedthemtoexpandroleoflivertransplantationintocancercare.

Again, this was an amazing team effort that was self-initiated by a group of physicians and staff (from multiple DepartmentsintheSCCandHospital,includingmanyothersnotnamedhere),whoweresolelymotivatedtoprovidethe bestcareforthepeopleofOklahoma

CongratulationsandWellDone!

Ajay

‘A Special Angel in Live’ - OUHealthTransplantInstituteSavesLives

-StoryprovidedbyOUHealth|OUDivisionofMarketingandCommunications

Timeisoftheessenceforpatientswaitingfororgantransplants.Organdonorsaredesperatelyneededastheaverage waitforakidneytransplantisfouryears.

“It takes 10 to 12 years to be on a list to get a kidney on the East and West Coasts,” said Pam Toho, RN, kidney and pancreascoordinatorforpediatricsandadultsattheOUHealthTransplantInstitute,locatedinOklahomaCity.“Andin theBibleBelthere,ourwaittimeisfourtosixyearsforthemtogetakidney.So,allthepeoplethatcanareflyinginto OklahomaandtheBibleBelt.

It’severyone’srighttomulti-listinmanystatestogetakidney,liver,orapancreasquicker,Tohosaid TheOUHealth TransplantInstitutehasa275-mileradiusoflocalorganoffersthattheyreceivefirst Ifthereisnotalocalorganmatch, thenthesearchgoesnational

“WewantthemtostayhereatOU,butourwholemindsetistobeanadvocateforthepatient,”Tohosaid.

Oneofherfavoritethingsaboutbeinganurseiscallingsomeonetosay,“Hey,wehaveapotentialorganofferforyou. Todaycouldbeyourday.”

Thereremainafewhurdlestoovercomebeforetheygettothefinalfinishlineforanorganthatmatchesthem.

“Wehavetoseeiftheyhavetobedialyzed.Whenwetaketheirblood,wemakesurethereisnoinfectionintheirbodies becauseifwe’regoingtotransplantsomeoneintheOR,wewipetheirimmunesystemout.”

Ittakesthreemonthsfortheimmunesystemtorebound,sothereshouldbenoopenwoundsorsorespresentonthe patient.Harmcouldbedoneifinfectionsarepresent.

AnadultmalerecentlyflewinfromCaliforniawherehehadbeenonawaitlistforfiveyears Theoperatingroomwasset forhimafterthecrossmatchwasdone Bloodwasflowninduringthemiddleofthenight Themedicalstaffobserve patientscloselytoensuretheirimmunesystemishealthy

“It’salmostlikeaseesawwithdoctorsbalancingtheirmedications,lookingatpeaksandthroughstogetatherapeutic level,”Tohoexplained.“That’swhatwelookfor,soyourbodydoesn’tattackthekidneyandrejectit.”

Organ recipients continue to be monitored for three to five years, getting them evaluated and keeping them healthy. Onceatransplantiscompleted,thepatientisseentwiceaweekforthefirstthreemonths;thenonceeverytwoweeks foracoupleofmonths,followedbyonce-a-monthevaluationsforayearortwo.

“Thenwereferthembacktotheirnephrologistandseethemonceayeartokeeptabsontheorganitself.Wehavea relationshiptoseeiftheyneedakidneyagain,”shecontinued.

“Then we refer them back to their nephrologist and see them once a year to keep tabs on the organ itself We have a relationshiptoseeiftheyneedakidneyagain,”shecontinued

TheOUHealthTransplantInstituteaverages40-50pediatricandadultkidneytransplantsayear,involvingbothlivingand deceasedkidneydonors.Eachyear,thatincludes7-10pediatrickidneytransplants.

“That’sexciting.It’sbeenawhilesincewe’vehadparentsthatwereabletodonate,”Tohosaid.

However, it looks like two pediatric donations will be processed. Toho said these donations will give children the best long-lastingkidneystheOUHealthTransplantInstitutecanoffer.

“A living donor related kidney is the very best kidney,” Toho said. “The length of time that it lasts we’ve seen some peoplekeeptheirkidneysaslongas30yearsforalivingdonorrelated.Foranormallifespanofatransplantedkidney fromadeceaseddonor,whichisanamazinggiftoflifeaswell,theaverageissevento10years.Andtheywilllikelyneed anotherkidney.”

Toho said it is her greatest privilege to work with a 38-person team to save lives. According to the United Network of Organ Sharing, the OU Health Transplant Institute has a 100 percent, 3-year-patient survival rate for living donor and deceased donor transplants at Oklahoma Children’s Hospital OU Health, Toho said and the publicly reported SRTR website

It’shardforTohotoexplainthejoythatbeingpartofanorgantransplantteamhasbroughttoherlife.

“Ihavearelationshipwithallofthesekids.Youjustformrelationshipswiththemforever,”shesaid.“Youfeellikeyouare aspecialangelintheirlife.Theyjusthaveabondwithyou.”

CITATION:

A Special Angel in Life - OU Health Transplant Institute Saves Lives (2024, January) https://oknursingtimes com/02-12-24/a-special-angel-inlife-ou-health-transplant-institute-saves-lives/

JasonS.Lees,MD,FACS

RobertD.Gordon,Jr.ProfessorofSurgery SectionChiefAcuteCareSurgery&Burns AssociateDeanofGraduateMedical Education-DesignatedInstitutionalOfficial ViceChairofEducation OUCollegeofMedicine|OUHealth DepartmentofSurgery

Coordinators

BertaOrta

LeadResidencyProgramCoordinator GeneralSurgeryResidency

KaraMcCroskey EducationProgramCoordinator GeneralSurgeryResidency

RavenNelson

LeadEducationProgramCoordinator PediatricSurgery&SurgicalCriticalCareFellowships

MagaliOchoa

PlasticSurgeryFacultyAssistant SeniorEducationProgramCoordinator

AcademicFaculty

AjayJain,MD ProgramSiteDirector, GeneralSurgeryResidency

KristinaBooth,MD AssociateProgram Director,GeneralSurgery Residency

FrankWood,MD AssistantProgram Director,GeneralSurgery Residency

CatherineHunter,MD PediatricSurgery Fellowship ProgramDirector

SuhairMaqusi,MD Plastic&Reconstructive SurgeryFellowship ProgramDirector

AlexanderRaines,MD Co-DirectorofSurgical ClerkshipResidency ProgramSiteDirector-OU Edmond

JeremyJohnson,MD Co-Director,ThirdYear Clerkship

AlessandraLandmann,MD FourthYearSurgery ClerkshipDirectorSurgical CriticalCareFellowship ProgramDirector

JasonLees,MD AssociateDeanofGraduate MedicalEducation-Designated InstitutionalOfficial

MorganBonds,MD AssistantDeanofAdmissions CollegeofMedicine

E D U C A T I O N

LeesNamedAssociateDeanofGraduateMedicalEducation

-StorybyOUDivisionofMarketingandCommunications

In May 2024, the College of Medicine announced the appointment Jason S. Lees, M.D. as the new associate dean of Graduate Medical Education (GME) and the college’s Designated Institutional Official (DIO). Lees brings a wealth of experienceandacommitmenttoexcellenceinmedicaleducation,clinicalpractice,andresearchtothisrole.

“IamtrilledtowelcomeDr.JasonLeesastheAssociateDeanofGraduateMedical Education,”saidIanF.Dunn,M.D.,FACS,FAANS,executivedeanofthecollege.“His unwaveringdedicationtoeducation,research,clinicalexcellence,andleadership madehimtheidealchoicetoleadourgraduatemedicaleducationprogramsintothe future.”

AnativeofEdmond,LeesisdeeplyrootedinthestateofOklahomaandhasan impressiveacademicbackground hegraduatedMagnaCumLaudewithaBachelor ofScienceinZoologyfromtheUniversityofOklahomabeforeearninghisDoctorof MedicinedegreefromtheOUCollegeofMedicine Followinghismedicaleducation, LeescompletedhisresidencyinGeneralSurgeryatOU,wherehewashonoredasthe LloydRaderOutstandingGraduatingResident.

LeesfurtheredhistrainingwithafellowshipintraumaandsurgicalcriticalcareatJacksonmemorialHospitalandthe University of Miami. He then pursued a surgical education research fellowship through the Association of Surgical Education.

Throughouthiscareer,Leeshasdemonstratedacommitmenttoadvancingmedicaleducationandclinicalcare.Hehas servedastheprogramdirectoroftheGeneralSurgeryResidencyprogramsince2012,overseeingitssignificantgrowth and achieving outstanding board passage rates. According to Dunn, Lees’ leadership has been instrumental in the successoftheprogram,whichhasgarnerednationalrecognition.

“IamhonoredtohavebeennamedtheassociatedeanofGraduateMedicalEducationattheOUCollegeofMedicine,“ said Lees “I am deeply committed to fostering a supportive learning environment where residents and fellows can thrive,andIlookforwardtoworkingcollaborativelywithcolleaguestoupholdthehigheststandardsofclinicalmedical education”

Lees’appointmentcomesatapivotaltimeformedicaleducation,andhisexpertisewillbeinvaluableastheCollegeof Medicinecontinuestoinnovateandadapttotheevolvingneedsofhealthcareprofessionalsandpatients.

“I am confident that in his new role, Dr. Lees will continue to champion excellence in graduate medical education, mentorship,andprofessionaldevelopmentforourresidentsandfellows.Hewillworkcloselywithleadersacrossthe College of Medicine to ensure the highest standard of training, equipping the next generation of physicians for unparalleledsuccess,“saidDunn.

CITATION:

Lees

OUCollegeofMedicineAppointsNewAssistantDeanstoLeadGraduate MedicalEducationProgram

-StorybyOUDivisionofMarketingandCommunications

TheUniversityofOklahomaCollegeofMedicinehasappointedKristinaBooth,ChristinaHensonandMubeenShakiras assistant deans in its Graduate Medical Education program. The expansion of the leadership team will support advancementsinprogrammanagement,learnerassessmentandwellnessinitiativesforresidentsandfellows. WithnewAccreditationCouncilforGraduateMedicalEducation(ACGME)requirements onthehorizon,theOUCollegeofMedicineisstrengtheningtheconnectionbetweenthe sponsoringinstitutionanditscoreclinicalsites,saysJasonLees,MD,FACS,associate deanofgraduatemedicaleducationandageneralandtraumasurgeonatOUHealth. “Theroleisbecomingmoreexpansive,requiringabroaderskillsetandoffering significantopportunitiesforprogramdevelopment Wearefocusedonhelpingdirectors andcoordinatorslearnbestpracticesfromeachotherandonsettinghighstandards inprogramquality,”Leessaid

ThenewassistantdeanswillhelpleadtheGraduateMedicalEducationprogram, supportingtheOUCollegeofMedicine.

KristinaBooth,MD,FACS,willserveasassistantdeanforprogramdevelopment, learnerassessmentandwellness.AnassociateprofessorintheOUDepartmentof Surgery,shehasbeenassociateprogramdirectorforthegeneralsurgeryresidencyfor six years, where she launched a well-being curriculum that includes policies for lactating residents, resident competitions and social activities. She has led faculty development efforts, introducing innovative evaluation techniquesandisnationallyrecognizedforadvancingcompetency-basededucationthroughtheSocietyforImproving MedicalProfessionalLearningandtheAmericanBoardofSurgery’sEntrustableProfessionalActivitiesinitiative.Shehas alsocontributedtonationaleducationprojects,presentednationallyandmentoredassociateprogramdirectors.Within the OU College of Medicine, she serves on the Academy of Teaching Scholars Executive Committee, is a Student Learning Community Mentor and received the Dewayne Andrews Excellence in GME Teaching award A native Oklahoman,sheearnedabachelor’sdegreeatOklahomaBaptistUniversity,amedicaldegreeandsurgicaltrainingat OUCollegeofMedicineandafellowshipincolorectalsurgeryatTexasHealthPresbyterian/UTSouthwestern Inthenew role,shewillpromoteGMEbestpractices,supportprogramdevelopmentandenhanceresidentwellnessinitiatives

CITATION:

OU College of Medicine Appoints New Assistant Deans to Lead Graduate Medical Education Program (2024, November) https://www ouhsc/ news/details/ou-college-of-medicine-appoints-new-assistant-deans-to-lead-graduate-medical-education-program.

AcademyofTeachingScholars

LaceyMcNally,PhD TenuredProfessorofSurgery ViceChairofResearchAdvancement OUCollegeofMedicine|OUHealth DepartmentofSurgery

AcademicFaculty

WilliamBerry,Ph.D. AssistantProfessor

TabithaGarwe,Ph.D. AssociateProfessor

MinLi,Ph.D. Professor

KennethStewart,Ph.D. AssistantProfessor

https://redcap.ouhsc.edu/redcap/surveys/?s=8DCMJAC488representsaone-stop shopforcontactingtheOUCARESteamforassistancewithbiostatistics,IRBsubmissions, StudyCoordinator/ResearchNurse,andresearchtissueprocessing/staining

R E S E A R C H

PancreaticCancer

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ResearchersatOUHealthStephensonCancerCenterattheUniversityofOklahomaHealthScienceshaveembarkedon a revolutionary new research study that could improve the detection of a deadly disease pancreatic cancer and givepatientsachancetolivelonger,healthierlives.

Theresearchfocusesonaninnovativecombinationofimagingtechniques:anewly createdcontrastagentthatrecognizespancreaticcancercells,pairedwithMultispectra OptoacousticTomography,orMSOT.Together,theapproachcandetectpancreatic cancercellsthewidthofaneyelash approximately10timesmoremagnitudethan whatiscurrentlypossible.TheresearchisledbyLaceyMcNally,Ph.D.,and AjayJain,MD,whoareprofessorsofsurgeryattheOUCollegeofMedicine Theyreceiveda$3milliongrantfromtheNationalCancerInstituteoftheNational InstitutesofHealthforthisproject,whichisbelievedtobeamongthefirstofitskind intheworld

“Pancreaticcancerisoneofthehardestcancerstocurebecauseitisdifficulttodetect cancercellsatthemicroscopiclevel,”Jainsaid.“Becausethereareusuallynoearly symptomsofpancreaticcancer,itistypicallynotdiagnoseduntilafterithasspread, andoutcomesareverypoor abouta9%overallchanceofsurvival.Surgeryand chemotherapyofferthepatientsthebestchance,butforsurgerytowork,wehaveto removeallthecancer,andthatisdifficulttodo.”

Thenewimagingapproachaimstoimprovethedetectionofpancreaticcancercellsatthemicroscopiclevel,orabout 200 microns, about as thin as an eyelash. Current imaging options like the CT scan only detect cancer when it grows larger,aboutacentimeterinsize.

Thepromiseofthenewimagingapproachisinthecombinedstreng elements Inthelaboratory,McNallydevisedacontrastagentuniqu cancercells WhentheagentisdeliveredviaanIV,itcandifferentiat cancercellsfromothercellsbecausetheenvironmentofpancreatic Whenthecontrastagentencountersthatacidity,itsdyeessentially

Theothercomponent,theMSOTdevice,worksinconcertwiththec TheMSOTdeliversinfraredlightintothebody,whichstimulatesthe agent.Thatstimulationcreatessoundwaves,whichtheMSOTdevic convertsintocolors.Theresultisanimagesodetailedthatitcaptur thatotherwisewouldevadedetection.

“This is a hybrid approach that accomplishes what a CT cannot,” McNally said “Pancreatic cancer often creates tentaclesthatspreadoutbeyondtheprimarytumor Currently,thereisnowayforthesurgeontoknowwheretheyare ButifthesurgeryteamcanusethisMSOTapproachintheoperatingroom,itcantelltheminrealtimewherethecancer hasmetastasizedsotheycanremoveit.”

Thatcapabilitywouldbeagame-changerforpancreaticcancersurgeons.Pancreaticcancerdisproportionatelyaffects people 60 and older, who face greater risks from a major operation than younger patients do and usually cannot withstandasecondsurgery.

“Thefirstquestionspatientsaskmeare,‘Willthesurgerybeworthit?Whatarethechancesthatyou’llgetitall?’This approach,ataverymicroscopiclevel,appearsabletoinformuswhetherwearegettingallthecancer,”Jainsaid.

Thenewimagingtechniquecouldalsohelpsurgeonsplanthesurgicalapproachtheywanttotake.IftheMSOTdevice reveals,forexample,thatcancerhasinvadedthetwocriticalbloodvesselsthathugtheheadofthepancreas,surgeons wouldconducttheproceduredifferentlythaniftheydidn’tknow.Ifchemotherapyisgivenbeforesurgery,theimaging couldtellwhethercancerouscellsonthebloodvesselsaredeadorifmicroscopiccancerisstillpresent

Ultimately,thenewimagingapproachcouldbeusedasascreeningtoolinpatientswhofaceahighriskofpancreatic cancer,suchasthosewhohaveafamilyhistoryorhaveageneticpredisposition “Earlydetectionofpancreaticcancer offers the best chance of a cure,” Jain said. “If we could detect the cancer at an early, microscopic stage, it could be curable.”

Thegrant'sfundingwillallowMcNallyandJaintocontinuetestingtheimagingtechnique.McNallyisaninternational leaderforherresearchexpertiseinusingtheMSOTdevicewithcontrastagentsshehasdevelopedforvariouscancers. SheistestingtheimagingapproachinseveralotherclinicaltrialsatOUHealthSciences,includingarecentlycompleted studyinbreastcancer.WhileMSOTtechnologyisnotnew,itisnovelinmedicine,andfundingagenciesliketheNIHare increasinglysupportingstudiesinthefield.McNallyandJain’sgrantscoredinthefirstpercentileoutofapproximately 55,000grantssubmittedlastyeartotheNationalCancerInstitute,whichpointstothestrengthoftheresearch.

“Thistypeofresearchcollaborationbetweenatranslationalscientistandasurgeonisextremelyunusual,”McNallysaid.

“We have the opportunity to improve a surgical technique. The scientific and medical communities have made great stridesintreatingsometypesofcancer,butpancreaticcancerpatientshavethepoorestsurvival Theoutcomeofthis researchcouldfundamentallychangepeople’slives”

The University of Oklahoma and Georgia State University jointly own pending patent applications on contrast agents andusingtheMSOTdevicewithcontrastagents.

Research reported in this press release is supported by the National Cancer Institute, a component of the National Institutes of Health, under award number 1R01CA281098-01A1 CITATION:

LiservesasPresidentofAmericanPancreaticAssociation

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MinLi,Ph.D.,aGeorgeLynnCrossProfessorofMedicine,SurgeryandCellBiologyattheUniversityofOklahomaCollege ofMedicineandAssociateDirectorforGlobalOncologyatOUHealthStephensonCancerCenter,willreceivethe2024 PaladePrizefromtheInternationalAssociationofPancreatology

ThePaladePrize,theIAP’smostdistinguishedawardf recognizesLi’scontributionstothefieldofpancreatol discoveringnewmethodsofidentifying,diagnosinga pancreassuchaspancreaticcancer.Theawardisnam whowontheNobelPrizein1974forhispioneeringwo pancreaticcelltype Liwillreceivetheprizeduringthe andhewillgivealectureoncancercachexiaandmeta

LihasbeencontinuouslyfundedbytheNationalCanc theNationalInstitutesofHealth,forthepast15years, grants.Hiscontributionstosciencefocusonthreeare

Development of a combination therapy for pancreatic cancer using a novel surgical mouse model. As part of this work,hislaboratorywasthefirsttodiscovertheroleofazinctransportercalledZIP4inbothpancreaticcancerand cachexia,amuscle-wastingconditionthatoftenoccursintandemwithpancreaticcancer.

Metabolic reprogramming and muscle wasting in pancreatic cancer. In this area, Li searches for a method of controllingtherapidweightlossofcachexia,whichhasnotreatment.Heiscurrentlyfocusedontheroleofseveral enzymesandgrowthfactorsintheprogressionofcachexia.

Immunotherapy of pancreatic cancer. Because most immunotherapy drugs alone are not effective against pancreatic cancer, Li’s team developed a phototherapy/immunotherapy combination treatment that has been highlyeffectiveinmicewithmetastaticpancreaticcancer

Lihaspublished216articlesinhigh-impactpeer-reviewedjournalsandhasgivenpresentationsonhisresearcharound the world He has also mentored more than 30 graduate students and postdoctoral fellows, who have gone on to researchcareersinacademiaandindustry,aswellasjuniorfacultymemberswhoarebeginningtheircareers.

Li is immediate past president of the American Pancreatic Association and is a standing member of the NIH Developmental Therapeutics study section and an ad hoc member of many other NIH study sections. He is editor-inchief for the journal Cancer Letters and is an editorial board member for several other prestigious journals, including ClinicalCancerResearchandBMCMedicine.HeisalsoamemberoftheAmericanAssociationforCancerResearchand theAssociationforAcademicSurgeons.

HeholdsseveralothertitlesatOUHealthSciences,includingAssistantDeanforInternationalResearchCollaborationin theOUCollegeofMedicine;ViceChairmanforResearchintheDepartmentofMedicineandDepartmentofSurgery,OU College of Medicine; and co-leader of the Cancer Biology Program at OU Health Stephenson Cancer Center. He also holdstheVirginiaKerleyCadeEndowedChairinCancerTreatment.

CITATION: Li serves as President of American Pancreatic Association (2024, December) OU Medicine A Bold Step Forward Winter 2024-2025 Newsletter, pg 47

ResearchersDiscoverCell‘Crosstalk’ThatTriggersCancerCachexia

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NewresearchfromtheUniversityofOklahomarevealsapreviouslyunknownchainofeventssparkingthedevelopment of cancer cachexia, a debilitating muscle-wasting condition that almost always occurs in people diagnosed with pancreaticcancer.

Theresearch,ledbyMinLi,Ph.D.,aprofessorintheOUCollegeofMedicine,ispublishedinthejournalCancerCell.The studyisacollaborationwithresearchersfromJohnsHopkinsSchoolofMedicine,theUniversityofTexasHealthScience Center andYaleSchoolofMedicine.

In the study, researchers discovered that “crosstalk” between pancreatic cancer cells and macrophages (a type of immunecell)isthefirststeptowardtheonsetofcachexia.Macrophagesusuallyprotectthebodyfrominfection,butin thiscase,thepancreaticcancercellsrecruitthemtodoharm.Theirconversationinturnprompts increasedsecretionof TWEAK(TNF-likeweakinducerofapoptosis),aproteinknowntoplayaroleincachexiabybindingtoreceptorsonthe surfaceofmusclecellsandcausinginflammation Thatsequencetriggersthedevelopmentofcachexia

“Cancercachexiaisanunderstudieddisease,andtherearenogoodtreatments,nordoesnutritionalsupporthelpwith the symptoms,” Li said “People lose their appetite and lose weight quickly, and because of that, they are weak and muchlessabletotolerateaggressivetreatmentforpancreaticcancer.Thesignificanceofthisstudyisthatitprovides evidenceofanunderlyingmechanismofcachexia.Itisnotthecancercellsaloneormacrophagesalonethatstartthe processofcachexia,butthefactthattheyaretalkingtoeachother.”

Cancercachexiaisn’tagivenwitheverycancer itrarelyoccurswithbreastcancerorbraincancer,forexample butit ismostprevalentinpancreaticcancer,Lisaid.Thestudy’sfindingsareimportantbecausebybetterunderstandinghow cachexia begins, researchers can potentially develop a way to stop the cascade of events. “It gives us a therapeutic window to intervene and potentially stop or reduce cachexia, thereby giving patients a better chance of fighting pancreaticcancer,”Lisaid.“Ournextstepistotrytodevelopadrug,possiblyonethatblocksthecrosstalkbetweenthe cancercellsandthemacrophages.

“This is a paradigm-shifting research publication because it represents a new way of understanding how cancer cachexia begins,” he added “The combination of pancreatic cancer and cancer cachexia significantly diminishes a person’squalityoflife Ifwecandetermineawaytoreducetheburdenofcachexia,peoplemayhaveabetterprognosis in their fight against pancreatic cancer, which now has a five-year survival rate of only 13% and is the third-leading causeofcancer-associateddeathsintheUnitedStates”

Pancreaticcancerisnotoriouslydifficulttofindinitsearlystages;over80%ofpatientswiththediseasearediagnosed when the cancer is advanced and treatment options are limited. In addition to providing a potential target for treatment, Li’s research may contribute to the ongoing search for a means of diagnosing pancreatic cancer earlier. Previousclinicalstudieshavesuggestedthatsixtoninemonthsbeforeadiagnosisofpancreaticcancer,peoplebegin losingfatthenmuscle.

“If a person loses more than 5% of their body weight in a six-month period for no reason, it could be a cause for concern,” he said. “Perhaps at some point, changes in a person’s body composition could help clinicians to diagnose canceratanearlierstagebeforeithasmetastasized.”

CITATION:

Researchers Discover Cell ‘Crosstalk” That Triggers Cancer Cachexia (2024, April) https://www ouhsc edu/news/details/researchers-discovercell-crosstalk-that-triggers-cancer-cachexia

Awards/Honors

Guilherme Barreiro,MD

ASPSTopPosterAwardAmericanSocietyof PlasticSurgery

OutstandingTeacherAwardOUHSC ASRM2024"Top24in2024"Poster-SensatePedicled AnterolateralThigh(ALT)FlapforReconstructionof Pelvi-PerinealandKneeRegionDefects

NarendraBattula,MD

SectionChiefofTransplantSurgery

MorganBonds,MD OklahomaUniversity405TopDoctors2024

KristinaBooth,MD OklahomaUniversity405TopDoctors2024 2024CastleConnollyTopDoctor

HaroldBurkhart,MD AlphaOmegaAlphaHonorSocietyFacultyMember 2024CastleConnollyTopDoctor Dean'sAwardforDistinguishedMedicalService,OUHSC OklahomaUniversity405TopDocs2024

NamedSeniorMedicalDirectorsforChildren’sServices ChairAdHocTenureReviewCommittee

StevenCarter,MD RussellPostierAwardforExcellenceinResident Teaching,OUHSC OklahomaUniversity405TopDocs2024

JuanCarlosClaros-Sorto,MD OklahomaUniversity405TopDocs2024

AlisaCross,MD

InauguralMemberofOUCollegeofMedicineAcademy ofTeachingScholars OklahomaUniversity405TopDocs2024 NamedSeniorMedicalDirectorforER/Trauma FacultyBoardMember

WilliamDooley,MD America’sTopDoctorsinCancer OklahomaUniversity405TopDocs2024

BarishEdilMD

2024CastleConnollyTopDoctor OklahomaUniversity405TopDoctors2024

ChristianElAmm,MD

2024CastleConnollyTopDoctor OklahomaUniversity405TopDoctors2024

JoshuaGierman,MD OklahomaUniversity405TopDoctors2024 StudentPromotionsCommitteeMember TheHarrisFoundationProfessorship

CatherineHunter,MD OklahomaUniversity405TopDoctors2024 OUHSCDepartmentofPediatricsMentorshipAward RosalindFranklinSocietySpecialAwardinScience Top50WomenLeadersofOklahomafor2024by WomenWeAdmireMagazine PresidentialProfessorshipAwardee

AjayJain,MD

AssociationofAcademySurgeryBasicScience TranslationalResearchAward OklahomaUniversity405TopDoctors2024 PromotionandTenureCommitteeoftheCollegeof MedicineMember TheG RaineyWilliamsResearchProfessorship

JeremyJohnson,MD 2023-2024OutstandingTeacherAwardOUHSC OklahomaUniversity405TopDoctors2024

AlessandraLandmann,MD OklahomaUniversity405TopDoctors2024

JasonLees,MD

OklahomaUniversity405TopDoctors2024 OKCThunderHealthcareChampionoftheGame SectionChiefofAcuteCriticalSurgery&Burns

MinLi,PhD

OUHSCProvostSeniorResearchAward VirginiaKerleyCadeEndowedChairinCancer Treatment

SuhairMaqusi,MD OklahomaUniversity405TopDoctors2024

LaceyMcNally,PhD

AssociationforAcademicSurgery’sBasicScience/ TranslationalResearchAwardOUHSC

FernandoMier-Giraud,MD

SAGESRecognitionofExcellence-CommunityPractice Committee 2023-2024OutstandingTeacherAwardOUHSC 2024CastleConnollyTopDoctor

MarkMims,MD OklahomaUniversity405TopDoctors2024

ChanceNichols,MD AesculapianAwardClinicalSciencesFacultyNomineeOUHSC

CeliaQuang,MD FrankA.ClinganSurgeryAward,OUHSC

AlexanderRaines,MD

OklahomaUniversity405TopDoctors2024 2024CastleConnollyTopDoc

MatthewReinersman,MD OklahomaUniversity405TopDoctors2024

EmilySwitzer,MD OklahomaUniversity405TopDoctors2024 PhysicianOUHealthWayChampionAward NamedSeniorMedicalDirectorofCriticalCare

FrankWood,MD

RussellG.PostierAwardforExcellenceinResident Education DewayneAndrews,MDAwardfor Excellencein TeachingGraduateMedicalEducation OklahomaUniversity405TopDoctors2024

Grants/Research

BarreiroGuilherme,MD

Developmentandstudyofalternativevascularsupply fordifferentflapconfigurations:PrincipalInvestigator (non-funded)

DevelopmentofanewstitchtechniqueDevelopmentof newneedleconfigurations:PrincipalInvestigator(nonfunded)

Developmentofsurgicaltechniquesandreconstructive alternativeswiththeaidoftherobot:Principal Investigator(non-funded)

Newarterialmechanicalcoupler:PrincipalInvestigator (non-funded)

Studyofalternativepainlessdonorsiteoptionsforskin grafts:PrincipalInvestigator(non-funded)

Studytheeffectsofdifferentnippleareolarpediclefor longerlastingresultsinbreastreductionsurgeries: PrincipalInvestigator(non-funded)

Thechallengetoovercometheripplingandthesilicon footprint:PrincipleInvestigator(non-funded)

NarendraBattula,MD

GrantASTSCareDxFacultyResearchGrantAmerican SocietyofTransplantSurgeons:Federal:Principal Investigator-100%-$100,000Current GrantResearchCareerDevelopmentAwardInnovative TechniquesforOrganPreservation,Repairand ReconditioningDepartmentofSurgery,Collegeof Medicine,UniversityofFlorida:State:Principal Investigator-100% -$25,000Closed IntramuralResearchResearchCareerDevelopment AwardUniversityofFlorida,DepartmentofSurgery: State:Yes:PrincipalInvestigator-100%-$2,5000Closed

WilliamBerry,PhD

ROCK,tightjunctionsandprematurityinthe pathogenesisofnecrotizingenterocolitisandneonatal sepsis:NIH/NDDK:Federal:5%-$1,600,000Current PDGFRBsignalinginprogressiveskindisease:NIH/ NIAMS:Federal:10%-$1,023,842Current Mechanismsdrivingtheformationofpost-operative peritonealadhesions:NIH/NIGMS:Federal-Other Investigator-55%-$1,250,000Current USPatent11,655,307Anti-Doublecortin-LikeKinase1 AntibodiesandMethodsofUse

JPPatent7366755Anti-Doublecortin-LikeKinase1 AntibodiesandMethodsofUse

HKPatent620200176845Anti-Doublecortin-LikeKinase

1AntibodiesandMethodsofUse

CNPatentCN111010867Anti-Doublecortin-LikeKinase1

AntibodiesandMethodsofUse

ScottBlair,DO

Serumidentificationandphenotypeassessmentof traumaticbraininjuryandassociatedconcussion disordersECMOSuccessAfterandElectrifyingNearDrowing;OUCares:$6,500Awarded ECMOsuccessafteranelectrifyingNearDrowning: PrincipleInvestigator-underreview TraumaticBrainInjury:MortalityandFunctional Outcomes/PrincipleInvestigator

BiomarkersinAcuteRespiratoryDistressSyndrome: DoesECMOalterRageandAng-2?PrincipleInvestigator$5,000Awarded

MorganBonds,MD

PancreasCancerSpecificPancreasCancerProbefor ImageProbeforImageGuidedResection:NCI:Federal: PrincipleInvestigator-$375,000Current

HaroldBurkhart,MD

TobaccoTreatmentPartnership:Co-Investigator$44,000Awarded

AProspectiveStudyofPatientswithHypoplasticLeft HeartSyndromeFollowingStageIISurgicalPaliation: MayoClinic:PrincipleInvestigator-Awarded Phase1SafetyStudyofAutologousUmbilicalCord BloodDerivedMononuclearCellsDuringSurgicalStage IIPalliationofHypoplasticLeftHeartSyndrome:Mayo Clinic:PrincipleInvestigator-Awarded “Riskstratificationandpredictivemodelingenabled personalizedmanagementoftricuspidregurgitationin hypoplasticleftheartsyndrome”:OCAST:Principle Investigator:$134,880Awarded

JuanClaros-Sorto,MD

AcquisitionofInvasivephenotypeinBiopsiedBreast TumorInflammationandBiopsy-Site-MarkerinBreast Cancer(MOSAIC):Co-Investigator-Awarded Developmentofanapoptosisbiosensorformonitoring ofbreastcancer:NIH:Federal-Co-InvestigatorAwarded

AlisaCross,MD

TransfusionandProthrombinComplexConcentrate Study:SitePrincipleInvestigator-Awarded DailyversusBIDDosingforLovenoxinSurgical Patients:OUCares:PrincipleInvestigator-$2,000 Awarded

ResidentConfidenceandOperativePerformance: TranslatingProceduralWorkshopsintothe‘RealLife’ OperatingRoom:PrincipleInvestigator-$3,500 Awarded

WilliamDooley,MD

ASafetyandEfficacyStudyofIntra-Operative RadiationTherapy(lORT)UsingtheXoftAxxentebx SystematthetimeofBreastConservationKomenFlax SeedLigninasaPreventionStrategyfor premenopausalwomenathighriskfordevelopmentof breastcancer:$139,000-Awarded SiteInitiationofNovilaseILTBreastCancerStudy ProtocolBR-002:$30,550-Awarded ARandomizedPivotalTrialtoassesstheSafetyand EfficacyofPreoperativeFocusMicrowavePlus Preoperative ChemotherapyvsPreoperative ChemotherapyaloneforCytoreductionofLargeBreast cancerinfemalepathiswithintactbreast:$85,000 Awarded

KomenFlaxSeedLigninasaPreventionStrategyfor postmenopausalwomenathighriskfordevelopment ofbreastcancer.$295,000Awarded. ASBrSNipplesparingMastectomyregistry:Awarded Kansas-BreastCancerPreventionbyLetrozoleinHigh RiskWomen:NCIRO1CA122577-01 Awarded ExcelPreventionStudy.APhase3randomizedstudyof ExemestancevsPlaceboinpostmenopausalwomenat increasedriskofdevelopingbreastcancer:NCICCTG TrialMap3 Awarded

Grants/Research

WilliamDooley,MD(cont’d)

ARandomizedPhaseIIIcomparing16to18weeksof NeoadjuvantExemestance(25mgdaily)Letrozole (2.5mg)orAnastrozole(1mhinpost-menopausal WomenwithClinicalStageIIandStageIIIEstrogen ReceptorPositiveBreastCancer.Z1031:Awarded PredictionofresponsetoNeoadjuventchemotherapyin womenwithoperablebreastcancer(PT304) $42,000 Awarded

BarishEdil,MD

NovelImagingTechniquesintheDiagnosisand TreatmentofPancreaticCancer PrincipleInvestigator

$30,000 Awarded

ChristianElAmm,MD

NeurodevelopmentaloutcomesofCraniosynostosis Surgery:PrincipleInvestigator Awarded

JoshuaGierman,MD

TREOAbdominalStent-GraftSystem:Principal Investigator:Awarded ExtremityVascularTraumawithSoftTissueLoss(non funded)

ManagementofExtracranialCerebrovascularInjury(non funded)

EndovascularAorticAneurysmRepairattheOklahoma CityVA:A10YearExperience(nonfunded)

CatherineHunter,MD

Redoxregulationofcellularpathologiesinnecrotizing enterocolitis:Federal-PrincipalInvestigatorAwarded ROCK,Tightjunctionsandprematurityinthe pathogenesisofnecrotizingenterocolitisandneonatal sepsis:Federal-PrincipalInvestigator-RO1 $3,400,000 Awarded

RoleofCreatineMetabolisminNecrotizingEnterocolitis: Federal-Co-Investigator$398,750Awarded

AjayJain,MD

RandomizedPhase0PilotStudyofHighDose OmeprazoleinPatientswithPancreaticCancerPlanning toUndergoSurgicalTherapyforEvaluatingChangesof Biomarkers:PrincipalInvestigatorAwarded IdentificationofmicroRNAsinCachexiainAfrican AmericanswithPancreaticCarcinoma:Principal InvestigatorAwarded Investigatingwhetherhighdoseomeprazolecanmake pancreascancerssusceptibletocelldeaththrough alterationoftumorpHandsuppressionofautophagy: Co-InvestigatorAwarded Multicenterstudyinvestigatinghowpathologiccomplete responsetochemotherapycorrelateswithoutcomesin pancreascancerpatients:Co-InvestigatorAwarded Assessinghownutritionaloptimizationand preconditioningcanimproveoutcomesinpatients undergoingapancreaticduodenectomy:Awarded Assessmentoffrailtyinhepatobiliarypatients(non funded)

DevelopmentofContrastAgentstoFacilitateImageGuidedSurgery:NCI-PrincipalInvestigator:R01100%pending

TranslationalResearchAward:Foundation-Supporting Investigator-$35,000Awarded

JeremyJohnson,MD

EffectsofanExclusiveHumanMilkDiet(EHMD)on EnteralFeedingOutcomesofNeonateswithCongenital GastrointestinalDisorders(GCD):Supporting InvestigatorAwarded

BluntCerebrovascularInjuryinPediatricTrauma Patients:Co-InvestigatorAwarded TheAssociationofEssentialFattyAcidStatuswith SurgicalWoundComplications:Co-Investigator Awarded

TraumaandMildTBIinPediatricPopulation:APilot LongitudinalDescriptiveStudyAssessingPostConcussiveSymptoms,FunctionalandQualityofLife Outcomes:Co-InvestigatorAwarded Myofibroblastfunctionininfantperitonealadhesions: PHF-SupportingInvestigatorAwarded

JasonLees,MD

SplittingHairs-HowtoDifferentiateSternotomy PerformanceAmongSurgicalResidentsUsingaNovel TrainingProgram:PrincipalInvestigator$1,146 awarded

MechanismsDrivingtheFormationofPost-Operative PeritonealAdhesions:Foundation$250,000Awarded TheRollofPDGFSignalingMechanotransduction NexusIntheDevelopmentofPeritonealAdhesions: State:$45,000Awarded

GRITanditsassociationwithmedicalstudentspecialty choice:(non-funded)

SIMPLanalysisforcomplexityofcaseentry(nonfunded)

OfficeofTechnologyDevelopmentGrowthFund(nonfunded)

USPatent11,744,565SurgicalEvaluationApparatus andMethod

MeganLerner,HT(ASCP)

HistologyServicesforNecrotizingEnterocolitis; SupportingInvestigator

HistologyServicesforNeurosurgery/OUEngineering TBI:SupportingInvestgator

HistologyServicesforPancreaticCancer:Supporting Investigator

HistologyServicesforWoundHealing:Supporting Investigator

MinLi,PhD

LysinemethylationpromotesNFAT5activationand predictstheefficacyoftemozolomideuponEGFR activation:Pending Genisteinsuppressesgallbladdercancertumorigenesis andprogressionviadownregulatingERBB2mediated PTK6/AKT/MCMpathway:pending Developmentofcontrastagentstofacilitateimageguidedsurgery:Federal-NIHRO1$1,250,000Awarded MolecularMechanismofPancreaticCancer Oncogenesis(12thpercentile,pendingcouncilreview): PrincipalInvestigator-$1,250,000Awarded Pancreaticcancertrainingprogram:Federal-Principal Investigator$1,319,129

Prognosticmarkersforpancreaticcancermetastasis andresponsetotherapy(20 percentileoninitial submission,revised,pendingforreview) th Pancreaticcancercachexia:Federal-NIH/NCIPrincipal Investigator$7,500,000Awarded

Grants/Research

MinLi,PhD(cont’d)

Potentiatingasystemicantitumorresponseby interstitiallocalizedablativeimmunotherapyto synergizewithimmunecheckpointtherapyfor metastaticpancreatictumors;Federal-NIH1RO1

$1,991,744Awarded

RoleofZincDependentEMT-TranscriptionFactors(EMTTF)inPancreaticCancerMetastasis:Federal-NIH1RO1

$1,250,000Awarded

LaceyMcNally,PhD

OptoacousticDetectionofInflammationUsingMSOT Device:PrincipalInvestigator:Awarded PilottrialtoidentifymicroRNAsincachexiapatientswith pancreaticcarcinoma:Co-PrincipalInvestigator: Awarded

ARandomizedPhase0StudyofHighDoseOmeprazole inPatientswithPancreaticCancerPlanningtoUndergo SurgicalTherapyforEvaluatingChangesofBiomarkers: Co-PrincipalInvestigator:Awarded Ahybriddrugdeliverysystemfortargetingthethree hallmarksofpancreaticcancer:NationalCancerInstitute (NCI):SupportingInvestigator:R01CA292822-01 AssessmentofFLT-PETandMSOTforGVHD:National CancerInstitute(NCI):PrincipalInvestigator: R01CA289758-01:Pending

Developmentofahybridintraoperativeimagingprobe: NationalCancerInstitute(NCI):PrincipalInvestigator: R01CA285427-A1:Pending

Developmentofsmallmoleculedyes(COP)fordetection ofpancreaticcancerusingMSOT:NationalCancer Institute(NCI):PrincipalInvestigator: 2R01CA205941-07A1:Pending

Developmentofcontrastagentstofacilitateimageguidedsurgery:NationalInstituteofHealth(NIH), NationalCancelInstitute(NCI),OklahomaUniversity HealthSciencesCenterTheUniversityofOklahoma: PrincipalInvestigator:R01CA281098-01A1:20% $2928601:Awarded

Developmentofanapoptosisbiosensorformonitoring ofbreastcancer:NationalInstitutesofHealth(NIH)& NationalInstituteofBiomedicalImagingand Bioengineering(NIBIB):PrincipalInvestigator: R01EB034731-01:20%$2075527:Awarded BioengineeringProbioticBacteriumContrastAgentsfor MonitoringofInflammationAssociatedColitisUsing MultispectralOptoacousticTomography:National InstituteofBiomedicalImagingandBioengineering (NIBIB):Federal:(Co-Investigator):R01EB033919-01A1: 12%$766689:Awarded

Detectionofinflammationusingnoninvasive optoacouticimagingandartificialintelligence:National InstituteofDiabetesandDigestiveandKidneyDiseases: R01DK131750-01A1:Pending DevelopmentofaMini-probeforoptoacousticimaging: NationalCancerInstitute:Federal:R01CA268593

ActivelytargetednanocontrastagentsfacilitateimageguidedresectionofpancreaticcancerNationalCancer Institute:PrincipalInvestigator:2R01CA257862:Pending Monitoringneo-adjuvanttreatmentofbreastcancer: NationalCancerInstitute:Federal:PrincipalInvestigator: R01CA268375-A1:Pending Optoacoustic-GuidedSurgicalResection:National CancerInstitute:PrincipalInvestigator:R01CA271584: Pending

LaceyMcNally,PhD(cont’d)

PancreaticCancerTrainingProgram:NationalCancer Institute:T32CA258060-A1

TargetedNanocontrastFacilitatesImage-Guided Resection:NationalCancerInstitute:Principal Investigator:R01CA268989Pending

Non-invasiveassessmentofgraftvshostdiseaseusing optoacousticimaging:NIH:Co-PrincipalInvestigator: R21CA27121815%$352495:Awarded Multispectraloptoacoustictomographyforthe detectionofextranodalextensioninheadandneck cancer:NationalCancerInstitute(NCI):Supporting Investigator:R21CA286276-01

Non-invasiveassessmentofgraftvshostdiseaseusing optoacousticimaging:NIH:PrincipalInvestigator: R21CA27121815%$169469$116875:Awarded Tumor-SpecificNanocontrastAgentsforImproved DetectionofPancreaticCancer:Supporting Investigator:F31CA261044-01A1:Awarded Stromatargetedtheranosticnanoparticlesfor pancreaticcancer:NationalInstitutesofHealth/ NationalInstituteofBiomedicalImagingand Bioengineering:R01CA2123505%$228750$1694349: Awarded

FernandoMier-Giraud,MD

EffectofPsychotropicMedicationsonBariatricSurgery Outcomes:PrincipalInvestigatorAwarded FacilitatorsandBarriersRelatedtoStartingaCareerin AcademicSurgery:PrincipalInvestigatorAwarded 1-YearBariactricSurgeryOutcomesinNative AmericansComparedtoCaucasians:Principal InvestigatorAwarded Enterra®TherapyGastricStimulationSystemHDE Number:H990014:PrincipalInvestigatorAwarded

AlexanderRaines,MD

HeartRateVariabilityasaMeasureofStressandEEGdirectedMeditativePracticesinMedicalStudents ParticipatinginaStressManagementTrainingProgram AcademyofTeacherScholarsTheUniversityof Oklahoma:PrincipalInvestigator100%$5000Awarded

MatthewJ.Reinersman,MD

CHIO3Trial:ChemotherapyCombinedwithlmmune CheckpointlnhibitorforOperableStagelllA/BNonSmallCellLungCancer,SCCOklahomaTribalRural, UrbanCancerScreening:PrincipalInvestigator$59,010 Awarded

ChemotherapyCombinedwithlmmuneCheckpoint lnhibitorforOperableStagelllA/BNon-SmallCellLung Cancer:PrincipalInvestigatorAwarded TSETforMobileLungCancerScreening:CoInvestigatorAwarded

Grants/Research

FrankWood,MD

DoesParticipationDuringResidencyinUniversity-Wide LeadershipCouncilsPredictGraduateRetention?: PrincipalInvestigatorPrincipalInvestigator(nonfunded)

EffectsofHistoricalRedliningandGunViolencein OklahomaCity,Oklahoma:PrincipalInvestigator(nonfunded)

PenetratingTraumainChildrenDuringtheCovid-19 Era:PrincipalInvestigator(non-funded)

DoesResidencyMatchRankOrderPredictGraduate SurgeryResidentPerformance?:PrincipalInvestigator (non-funded)

UtilizationofCardiopulmonaryBypassinTrauma Patients:SitePI(Non-Funded)

CharacterizingPatternsofInjuryandAssessing OutcomesAssociatedwithBurnsSustainedWhile SmokingonHomeOxygen.SupportingInvestigator (non-funded)

Presentations

GuilhermeBarreiro,MD

Local-Lecture:IntroductiontoPlasticandReconstructive Surgery:PlasticSurgeryInterestGroupAnnual Conference:SectionofPlasticSurgery,Collegeof Medicine,UniversityofOklahoma:OklahomaCity,OK 1/1/24

International-Poster:SensatePedicledAnterolateral Thigh(ALT)FlapforReconstructionofPelvi-Perinealand KneeRegionDefects:AmericanSocietyfor ReconstructiveMicrosurgery:Nassau,BS:1/1/24

International-Poster:SuperficialSuperiorEpigasticFlap: AmericanSocietyforReconstructiveMicrosurgery: Nassau,BS:1/1/24

KristinaBooth,MD

National-GrandRounds:EntrustableProfessional Activities:why,what,howandsowhat?:EPAGrand Rounds,SurgicalResidencyProgramInvitedGuest Lecture:KaiserPermanenteLAMC:LosAngeles,CAVirtualGrandRounds:11/12/24

National:Panel:ColonandRectalSurgeons:TheBottom LineforEmergencyColonSurgery: AmericanCollegeof Surgeons(ACS)ClinicalCongress2024:AmericanCollege ofSurgeons(ACS):SanFrancisco,CA:10/1/24

National:OralPresentation:ComparingLevelof Autonomy&PerformanceAmongstSurgicalResidents AcrossResidenciesNationwide:AssociationofProgram DirectorsinSurgery(APDS)-SurgicalEducationWeekPaperSessionIII-EntrustableProfessionalActivities (EPA)andCompetencyBasedMedicalEducation(CBME) AssociationofProgramDirectorsinSurgery(APDS)SurgicalEducationWeek:HyattRegencyOrlando,FL: 4/26/24

National:Workshop:AmericanBoardofSurgery, EntrustableProfessionalActivites(EPAs):Departmentof Surgery,IndianaUniversity,SchoolofMedicine: Indianapolis,IN:4/26/24

National:Workshop:EPAsAreHere:Strategiesfor IncreasingEngagementandMeaningfulUseatYour Institution:AssociationofProgramDirectorsinSurgery (APDS)EntrustableProfessionalActivities(EPA): Workshop:TheAmericanBoardofSurgery(ABS):School ofMedicine,IndianaUniversity:4/26/24

HaroldBurkhart,MD

National:OralPresentation:RepairofaComplex UnicuspidAorticValveusingGeometricRing Annuloplasty:STS2024The60thAnnualMeeting:The SocietyofThoracicSurgeons:SanAntonio,Texas: 1/28/24

JuanClaros-Sorto,MD

Regional:Lecture:JourneyfromDiagnosisto Survivorship:Project31SurvivorsExpo:P31:Oklahoma City:6/22/24

AlisaCross,MD

National:OralPresentation:Pediatricbluntthoracic aorticinjuries:shouldmanagementbedrivenbypatient sizeorpatientage?:AnnualPediatricTraumaSociety: PediatricTraumaSociety:Charlotte,NC:11/8/24

Local:OralPresentation:OrthopedicsGeriatricHip FractureProtocol:OrthopedicDepartmentLecture: OklahomaUniversityHealthSciencesCenter,Collegeof Medicine,DepartmentofOrthopedicSurgery:Oklahoma City:7/15/24

Presentations

AlisaCross,MD(cont’d)

Local:Panel:SchwartzRounds:TheImpactofTrauma onCaregivers:SchwartzRounds:OUHealth:5/17/24

National:OralPresentation:RiskFactorsforIn-Hospital ComplicationsinIsolatedGeriatricHipFractures: SouthwestSurgicalCongress:4/24/24

International:Lecture:NutritionintheSurgicalPatient: AmericanCollegeofSurgeonsHealthOutreach: ProgramforEquity:AmericanCollegeofSurgeons HealthOutreachProgramforEquity’s(HOPE)/NGOHMARIACyberLectureProgramPuertoRicoMedical Schools:Cyber/PuertoRicoMedicalSchool:1/30/24

ChristianElAmm,MD

International:Poster:Lengtheningthehardpalate EuropeanCleftPalateCraniofacialAssociation:ECPCA: Milan,Italy:6/25/24

International:OralPresentation:Simulation,Virtual Reality(VR)andAugmentedReality(AR)inCleftand CraniofacialCare–StateoftheArtandtheRoadAhead: AmericanCleftPalateCraniofacialAssociationAnnual Meeting:ACPA:Denver,CO:4/11/24

BenjaminGreif,MD

National:OralPresentation:Pediatricbluntthoracic aorticinjuries:shouldmanagementbedrivenby patientsizeorpatientage?:PediatricTraumaSociety, AnnualMeeting:PediatricTraumaSociety:Charlotte, NC:11/8/24

CatherineHunter,MD

National:Paper:ImprovingSurvivalatQuaternaryCare NICUsFollowingNecrotizingEnterocolitisTotalis,a ConditionPreviouslyConsidered100%Lethal: InternationalPediatricIntestinalFailureand RehabilitationSymposium:Pittsburg,PA:9/27/24

Regional:Keynote/PlenaryAddress:Necrotizing Enterocolitis:StridesinScienceandSurgery:Groff Lectureship:UniversityofLouisville/NortonChildren's Hospital:Louisville,Kentucky:6/7/24

International:Poster:ImprovingSurvivalatQuaternary CareNICUsFollowingNecrotizingEnterocolitisTotalis, aConditionPreviouslyConsidered100%Lethal: PediatricAcademicSocieties(PAS)2024:Pediatric AcademicSocieties(PAS):Toronto,Canada:5/1/24

National:OralPresentation:HyperinflammatoryState SeeninActiveNecrotizingEnterocolitisRemainsEven PostRecovery:AmericanPediatricSurgicalAssociation AnnualMeeting:AmericanPediatricSurgical Association:Phoenix,AZ:5/16/24

Local:OralPresentation:NasogastricTubes:An OpportunityforImprovedUnderstandingand Education:PartnersinQualityConference:Partnersin Quality:OklahomaCity,OK:3/12/24

Local:Poster:RandomizedcontroltrialoftheThopaz+ digitalchesttubedrainagesystemversusanalogin pediatricpatients:PartnersinQualityConference: PartnersinQualitiy,OklahomaUniversityHealth SciencesCenter:Virtual/DigitalPresentation:3/12/24

National:Accepted:OralPresentation:Caveolin-1 DeficiencyEffectsonTightJunctionsandApoptosisin NecrotizingEnterocolitis:AcademicSurgicalCongress SUS:Washington,DC:2/8/24

National:OralPresentation:Retained HyperinflammatoryStatePostRecoveryfrom NecrotizingEnterocolitis:AcademicSurgicalCongress: AcademicSurgicalCongress:Washington,DC:2/7/24

CatherineHunter,MD(cont’d)

National:Poster:TheRoleofNADPHOxidase'sandtheir ContributiontoCellDeathinNecrotizingEnterocolitis: AcademicSurgicalCongress:AcademicSurgical Congress:Washington,DC:2/7/24

National:OralPresentation:GlutathionePeroxidase TwoGeneExpressionisUpregulatedinActive NecrotizingEnterocolitis:AcademicSurgicalCongress: AcademicSurgicalCongress:Washington,DC:2/6/24

Local:OralPresentation:Caveolin-1asaRegulatorof TightJunctionsandApoptosisinNecrotizing Enterocolitis:TheDepartmentofPediatricsAnnual ResearchSymposium:UniversityofOklahoma: OklahomaCity,OK:2/2/24

Local:Poster:GlutathionePeroxidaseTwoExpressionis UpregulatedinNecrotizingEnterocolitis:The DepartmentofPediatricsAnnualResearchSymposium: UniversityofOklahoma,DepartmentofPediatrics: OklahomaCity,OK:2/2/24

Local:Poster:MaternalWesternDietIncreases InflammatoryMarkersInBaboonOffspring:The DepartmentofPediatricsAnnualResearchSymposium: UniversityofOklahoma,DepartmentofPediatrics: OklahomaCity,OK:2/2/24

JeremyJohnson,MD

National:OralPresentation:Pediatricbluntthoracic aorticinjuries:shouldmanagementbedrivenbypatient sizeorpatientage?:PediatricTraumaSocietyAnnual Meeting:PediatricTraumaSociety:Charlotte,NC: 11/8/24

National:OralPresentation:TheATOMACcriteriafor pediatricbluntcerebrovascularinjury:anATOMAC multicenterstudy:PediatricTraumaSocietyAnnual Meeting:PediatricTraumaSociety:Charlotte,NC: 11/8/24

National:Abstract:AnA+PTRNprospective/retrospective studyofhypotensivechildrenwithbluntliverorspleen injury:WesternPediatricTraumaConference:Sundance, UT:7/14/24

AlessandraLandmann,MD

National:OralPresentation:Pediatricbluntthoracic aorticinjuries:shouldmanagementbedrivenbypatient sizeorpatientage?:PediatricTraumaSocietyAnnual Meeting:PediatricTraumaSociety:Charlotte,NC: 11/8/24

JasonLees,MD

National:OralPresentation:ComparingLevelof Autonomy&PerformanceAmongstSurgicalResidents AcrossResidenciesNationwide:APDS-Surgical EducationWeek-PaperSessionIII-EPAandCBME APDS-SurgicalEducationWeek:HyattRegencyOrlando, FL:4/26/24

PaulMcGahaII,MD

National:OralPresentation:Pediatricbluntthoracic aorticinjuries:shouldmanagementbedrivenbypatient sizeorpatientage?:PediatricTraumaSocietyAnnual Meeting:PediatricTraumaSociety:Charlotte,NC: 11/8/24

Presentations

FernandoMier-Giraud,MD

National:OralPresentation:StateofBariatricsand WeightLossMedicine:AmericanCollegeofSurgeons (ACS)OklahomaChapter:AmericanCollegeof Surgeons(ACS)OklahomaChapter:OklahomaCity,OK andVirtually:5/22/24

National:FridaySAGESVideoReel(NonCME)/Oral Presentation:RoboticSleeveGastrectomywithRepair ofMorgagniHernia:2024SocietyofAmerican GastrointestinalandEndoscopicSurgeons(SAGES) AnnualMeeting:SocietyofAmericanGastrointestinal andEndoscopicSurgeons(SAGES):Cleveland,OH: 4/19/24

ChanceNichols,MD

Local:OralPresentation:"PenetratingNeckTrauma": TraumaGrandRounds:UniversityofOklahomaHealth SciencesCenter:OklahomaCity,Oklahoma:10/10/24

National:OralPresentation:NotsoFAST:Changesin theDiagnosticYieldofeFASTbyResidentsoverthe AcademicYear:ACSQualityandSafetyConference: DenverColorado:7/20/24

MaheswaranPitchaimuthu,MD

International:Lecture:BasicsinLiver&Renal Transplant:DhanalakshmiSrinivasanUniversity SrinivasanMedicalCollegeandHospital:TamilNadu, India:1/1/24

FrankWood,MD

Local:Lecture:BallisticsandtheTraumaPatient: SeparatingFactfromFiction:OSUParamedicProgram: OklahomaStateUniversity:OklahomaStateUniversity -OKCHealthSciencesCenter:10/23/24

Local:Panel:ProgramDirectorPanelonResidency Interviews:CollegeofMedicine,Universityof Oklahoma:OklahomaCity,OK:10/23/24

National:Lecture:APainintheNeck:Quail,Crush Syndrome,andtheTreatmentofRhabdomyolysis: AmericanSocietyofAnesthesiaTechnologistsand Technicians2024AnnualMeeting:OklahomaCity, Oklahoma:9/26/24

State:Panel:ManagingSubspecialtyEmergencies: Trauma:OklahomaChapteroftheAmericanCollegeof Surgeons2024AnnualMeeting:OklahomaCity, Oklahoma:8/3/24

Local:Lecture:Fasciotomy-PearlsandPitfalls:Trauma GrandRounds:SectionofAcuteCareSurgery, DepartmentofSurgery,CollegeofMedicine,University ofOklahoma:OklahomaCity,OK:7/10/24

Publications& IntellectualContributions

NarendraBattula,MD

39056458/101177/00031348241268273/Pardue,K, Timmerman,M,Elgenaid,S,Hassell,L A,Battula,N R,Pitchaimuthu,M (2024) SuccessfulLiverTransplant FromaDonorWithSickleCellDisease TheAmerican surgeon,31348241268273

WilliamBerry,PhD

38613944/PMC11097602/101016/jmolimm202404002 Ramakrishnan,G.S.,Berry,W.L.,Pacherille,A.,Kerr,W. G,Chisholm,J D,Pedicone,C,Humphrey,M B (2024) SHIPinhibitionmediatesselectTREM2-induced microglialfunctions Molecularimmunology,170,35-45

ScottBlair,DO

39079438/101016/jamjsurg2024115858

Snyder,K B,Gushing,J,Quang,C Y,Stewart,K E, Sarwar,Z,Albrecht,R,Blair,S G (2024) Propofol administrationforinductionisassociatedwithperiintubationinstabilityintraumacriticalcareunit patients Americanjournalofsurgery,238,115858

KristinaBooth,MD

Booth,K K (2024) SCOREQuestionBank ThisWeekin SCORES'sAppendicicitisandDiverculitisQuiz. Booth,K K (2024) ThisWeekinSCORE’sAppendicitis andDiverticulitisquiz."ThisWeekinSCORE"Item Writer

HaroldBurkhart,MD

38196381/10.1017/S1047951123004432/Loeffler,K.A., Behere,S P,Williams,P K,Nakamura,Y,Burkhart,H M,Campbell,M D (2024) Reducedmorbiditywithearly surgicalligationofpatentductusarteriosusinextremely lowbirthweightinfants:aretrospectivesingle-centre study Cardiologyintheyoung,1-6

AlisaCross,MD

Martin,W T,Snyder,K B,Stewart,K E,Sarwar,Z, Starr,W.,Grady,A.,Ball,J.,Raines,A.R.,Cross,A.M. (2024) Title:BridgingtheGap:Comparisonof OutpatientClinicandEDPatientsUndergoing Cholecystectomy JournalofSurgicalResearch,300, 183-90.

WilliamDooley,MD

101158/1538-7445sabcs23-po2-22-04/Schwartzberg, B,Syed,A N,Bhatnagar,A,Rahman,S,Jones,V, Chang,A,Cockerham,T,Osborn,V,Cohen,R,Hodge, C,Lopez-Penalver,C,Chakravarthy,B,Dooley,W C, Madu,C,Okabe,A,Farha,M,Madrigrano,A,Morrison, C,Neuner,G,Wengler,C,David,S,Toosie,K, Stephens,B (2024) AbstractPO2-22-04:MedianFiveYearFollow-UpResultsfromtheMulti-InstitutionTrial fortheTreatmentofEarly-StageBreastCancerUsing Intra-OperativeElectronicBrachytherapy Cancer Research,84(9 Supplement),PO2-22-04-PO2-22-04. http://dxdoiorg/101158/1538-7445sabcs23-po2-22-04 38659868/PMC11042396/10.21203/rs.3.rs-4171651/v1/ Leslie,M,Pathak,R,Dooley,W C,Squires,R A,Rui,H, Chervoneva,I.,Tanaka,T.(2024).SurgicalDelayAssociatedMortalityRiskVariesbySubtypeinLocoRegionalBreastCancerPatientsinSEER-Medicare Researchsquare

Publications&IntellectualContributions

BarishEdil,MD

38429478/101038/s41556-024-01372-4/Murthy,D, Attri,K S,Shukla,S K,Thakur,R,Chaika,N V,He,C, Wang,D.,Jha,K.,Dasgupta,A.,King,R.J.,Mulder,S.E., Souchek,J,Gebregiworgis,T,Rai,V,Patel,R J,Hu, T.,Rana,S.,Kollala,S.S.,Pacheco,C.,Grandgenett,P. M,Yu,F,Kumar,V,Lazenby,A J,Black,A R, Ulhannan,S.,Jain,A.,Edil,B.H.,Klinkebiel,D.L., Powers,R,Natarajan,A,Hollingsworth,M A,Mehla, K.,Ly,Q.,Chaudhary,S.,Hwang,R.F.,Wellen,K.E., Singh,P K (2024) Cancer-associatedfibroblastderivedacetatepromotespancreaticcancer developmentbyalteringpolyaminemetabolismvia theACSS2-SP1-SAT1axis Naturecellbiology

ChristianElAmm,MD

ElAmm,C A (2024) HowIDoIt:LateralCanthopexy ISCFSNewsletter

ElAmm,C.A.(2024).NewTechnologies:Preoperative MarkingGetsaTechnologicalBoost ISCFSNewsletter

JoshuaGierman,MD

39650167/PMC11624567/10.1177/2050313X241297217/ Evans,A R,Kharbat,A F,Gierman,J L,Shakir,H J (2024).Intravascularlithotripsypriortotranscarotid arterialrevascularization:Atechnicaltaleoftwocases

SAGEopenmedicalcasereports,12, 2050313X241297217

https://wwwavensonlineorg/wp-content/uploads/ JSUR-2332-4139-12-0058pdf/Snyder,K B,Farnell,C, Buonpane,C (2024) OpenRepairofPediatric AortoentericFistulafromARemoteGastric TranspositioninCongenitalEsophagealAtresia:A MultidisciplinaryApproach.JournalofSurgery,12(1), 1-3 https://wwwavensonlineorg/wp-content/ uploads/JSUR-2332-4139-12-0058.pdf

BenjaminGreif,MD

38544967/PMC10965468/101016/jjvscit2024101463/ AbouAyash,J.,Greif,B.A.,Salzler,G.,Ryer,E.,Garvin,R. (2024) Transcervicalapproachtodistalextracranial internalcarotidaneurysm.(3rded.,vol.10,pp. 101463) Journalofvascularsurgerycasesand innovativetechniques

38510087/PMC10950828/101016/jjvscit2024101456/ Kerr,J P,Greif,B A,Salzler,G G,Ryer,E J,Garvin,R P (2024) Coronarystentmigrationtoaortawith successfulrecoveryduringaortobifemoralbypass (3rd ed,vol 10,pp 101456) Journalofvascularsurgery casesandinnovativetechniques

ArthurGrimes,MD 10.1007/s40137-024-00414-y/Follette,C.J.,Grimes,A., Detelich,D M,Martin,R S (2024) FindingValuein EmergencyGeneralSurgery.CurrentSurgeryReports, 12(8),245-251 https://apielseviercom/content/ abstract/scopus id/85195907098

ArthurGrimes,MD(cont’d) 101177/00031348241227195/Harrell,K N,Grimes,A, Gill,H,Reynolds,J K,Ueland,W R,Sciarretta,J D, Todd,S.R.,Trust,M.D.,Ngoue,M.,Thomas,B.W., Ayuso,S A,LaRiccia,A,Spalding,C M,Collins,M J, Collier,B.R.,Karam,B.S.,deMoya,M.A.,Lieser,M.J., Chipko,J M,Haan,J M,Lightwine,K L,Cullinane,D C.,Falank,C.R.,Phillips,R.C.,Kemp,M.T.,Alam,H.B., Udekwu,P O,Sanin,G D,Hildreth,A N,Biffl,W L, Schaffer,K.B.,Marshall,G.,Muttalib,O.,Nahmias,J., Shahi,N,Moulton,S L,Maxwell,R A (2024) Bone AnchorFixationintheRepairofBluntTraumatic AbdominalWallHernias:AWesternTraumaAssociation MulticenterStudy AmericanSurgeon,90(6),1161-1166 https://apielseviercom/content/abstract/ scopus id/85182213207 101093/jscr/rjae296/Blum,B,Grimes,A,Carroll,H L, Stettler,G R (2024) Cecalvolvulussecondaryto mesodiverticularband.JournalofSurgicalCase Reports,2024(5) https://apielseviercom/content/ abstract/scopus id/85192708820 101136/tsaco-2024-001394/Grimes,A,Stettler,G R, Nunn,A.M.(2024).Immediatechestwallstabilization followingthoracotomyforhemorrhageinsevereblunt thoracictrauma(1sted.,vol.9).TraumaSurgeryand AcuteCareOpen https://apielseviercom/content/ abstract/scopus id/85186962557

CatherineHunter,MD 101089/sur202454642rfs2023

Hunter,C J (2024) RosalindFranklinSocietyProudly Announcesthe2023AwardRecipientforSurgical Infections SurgicalInfections,25(7),477-477 https:// doi.org/10.1089/sur.2024.54642.rfs2023 39125983/103390/ijms25158416/Gershner,G H, Hunter,C.J.(2024).RedoxChemistry:Implicationsin NecrotizingEnterocolitis InternationalJournalof MolecularSciences,25(15),8416.https:// doiorg/103390/ijms25158416 10.1007/s43681-024-00525-3/Snyder,K.B.,Stewart,R. A,Hunter,C J (2024) Ethicalconsiderationsforthe applicationofartificialintelligenceinpediatricsurgery. AIandEthics https://doiorg/101007/ s43681-024-00525-3

https://doiorg/1021037/pm-22-41/Snyder,K B, Hunter,C J (2024) Theleakygut:anarrativeontherole ofepithelialpermeabilityinnecrotizingenterocolitis PediatricMedicine,7 38653916/DOI:101007/s40272-024-00630-0 Snyder,K B,Hunter,C J,Buonpane,C (2024) PerforatedAppendicitisinChildren:Management, MicrobiologyandAntibioticStewardship Paediatric Drugs,3,277-286. 38284399/10823418/Hunter,C J,Naumann,D (2024) NovelTextbookOutcomesforemergencylaparotomyin bothtraumaandnon-traumasettings:aDelphiexercise BritishJournalofSurgery. https://wwwavensonlineorg/wp-content/uploads/ JSUR-2332-4139-12-0058pdf/Snyder,K B,Farnell,C, Buonpane,C (2024) OpenRepairofPediatric AortoentericFistulafromARemoteGastricTransposition inCongenitalEsophagealAtresia:AMultidisciplinary Approach JournalofSurgery,Volume12(Issue1),1-3 https://wwwavensonlineorg/wp-content/uploads/ JSUR-2332-4139-12-0058pdf

Publications&IntellectualContributions

CatherineHunter,MD(cont’d)

38295192/101097/PEC0000000000003116/Leiva,T, Golubkova,A.,Snyder,K.,Johnson,J.J.,Hunter,C.J. (2024) PediatricTraumaticLumbarHerniasand AssociatedInjuries:ACaseSeries Pediatricemergency care,40(2),103-107 38250141/Snyder,K,Calkins,C,Golubkova,A,Leiva, T,Schlegel,C,Hunter,C J (2024) DespiteRecovery fromNecrotizingEnterocolitisInfantsRetaina HyperinflammatoryResponsetoInjury JInflammRes 101093/bjsopen/zrad145/Naumann,D N,Bhangu,A,Brooks,A, Martin,M,Cotton,B A,Khan,M,Midwinter,M J,Pearce,L,Bowley, D M,Holcomb,J B,Griffiths,E A,Abu-Abeid,A,Brooks,A, Peckham-Cooper,A,Dyas,A R,Adeyeye,A,Dogjani,A,Ball,A C, Wolthuis,A M,Quiroga-Garza,A,Karamarkovic,A R,Giordano,A, Fuchs,A,Julianov,A,Phillips,A W,Zimmermann,A, Charalabopoulos,A,Birkun,A A,Narvaez-Rojas,A R,Guner,A, Davis,A L,Vereczkei,A,Balla,A,Celotti,A,Romanzi,A,Trombetta, A,Beggs,A D,Robertson,A G,Petrosoniak,A,Davies,A R, Becerra-Bolaños,Á,Loria,A,Brillantino,A,Athanasiou,A,Isik,A, Ioannidis,A,Santos,A P,Saha,A K,Vilches-Moraga,A,Choudhry, A J,Tsuchiya,A,Smithers,B M,Wijnhoven,B P,Keeler,B D,De Simone,B,Birla,R,Mitra,B,Atanasov,B C,Badgwell,B,Nolan,B, Cotton,B A,Kang,B H,Duffy,C C,Ordoñez,C A,Gomes,C A, Mueller,C L,Reinke,C E,Lebares,C C,Hunter,C J,Villodre,C, Guldogan,C E,Seretis,C,Adams,C A,Pilgrim,C H,Varghese,C, Owoo,C,Meyhoff,C S,Fleming,C A,Stuart,C M,Lewis-Lloyd,C A,McLaughlin,C J,Stevens,C L,Graham,C A,Magee,C, Saunders,D I,Yeh,D D,Chan,D L,Felsenreich,D M,Holena,D N, Bawa,D,Bowrey,D J,Naumann,D N,Liu,D S,Chan,D S,Nag,D S,Haddad,D N,Corallino,D,Damaskos,D,Moris,D,Schizas,D, Korkolis,D.P.,Bagaria,D.K.,Adamovich,D.M.,Colquhoun,D.A., Bowley,D M,Singhal,D,Siddaiah-Subramanya,M,Kapoor,R, Wyncoll,D,Hai,D V,Avest,E T,Muttillo,E M,Picetti,E,Kelly,E, Baili,E,Pinto,E,Colak,E,Dixon,E,Reitano,E,Sultana,E,Mills,E C,Ley,E J,Osterman,E,Pivalizza,E G,Tokidis,E,Griffiths,E A, Ezanno,A-C,Catena,F,Pederiva,F,Coccolini,F,Nickel,F,Agresta, F,Tovar,FN,Abu-Zidan,FM,Brzeszczyński,F,ElBoghdady,M, Takeda,FR,Fleres,F,Pecchini,F,Carrano,FM,Pata,F,Mulita,F, Klevebro,F,Rodrigues,G,Gallo,G,Poillucci,G,Bass,G A, Aggarwal,G,Perrone,G,Roberts,G,Koukoulis,G,Zacharis,G, Baiocchi,G L,Pellino,G,Lisi,G,Dapri,G,Brisinda,G,Augustin,G, Christodoulidis,G,Imbriaco,G,Ducarme,G,Rasa,H K,Hamer,P W,Lederhuber,H,Plaudis,H,Uchino,H,Beji,H,Ferguson,H J, Cohen,H M,Wilson,I,Kryvoruchko,I A,Kuitunen,I,Benzoni,I, Merlini,I,Ose,I,Wani,I,Gockel,I,Negoi,I,Gribovskaja-Rupp,I, Tomasi,I,Olaoye,I O,Kenington,J C,Roth,J S,Rosenberg,J, Viganò,J,Williamson,J M,DeWaele,J J,Smith,J E,Nahmias,J, Stevens,J L,Rickard,J,Mah,J J,Waalwijk,J F,Yuval,J B, Kauppila,J H,Cuschieri,J,Brown,J B,Rivas,J G,Emamaullee,J, Lasithiotakis,K,McKenzie,K,Matsushima,K,Koivusalo,A I, Almond,L M,Konge,L,Jorgensen,L N,Genser,L,Napolitano,L M,Brown,L R,Kaplan,L J,Degrate,L,Bonavina,L,Moore,L, Gachabayov,M,Dornseifer,M D,Siddaiah-Subramanya,M, Abdulshafea,M,RibeiroJunior,M A,Migliore,M,Ceresoli,M, Clementi,M,Scarpa,M,Olausson,M,Sousa,M R,Giuffrida,M, D'Oria,M,Pacilli,M,Czerny,M,Reichert,M,Rutegård,M,Bahreini, M,Lee,M J,Martin,M J,Tolonen,M,Fehervari,M,Rho,M,Podda, M,Léger,M,Frountzas,M,Chisthi,M M,Lewis,M R,Bérubé,M, Oliveira-Cunha,M,Marsden,M E,Tez,M,Piccoli,M,Bath,M F, Flanagan,M,Gottlieb,M,Pearl,M L,Achiam,M P,Swart,M, Ukkonen,M,Bala,M,Ebrahim,M,AlAli,M N,Ortenzi,M,Ghalleb, M,HylanderMøller,M,Iqbal,M R,Ali,M A,Tarazi,M,Newton,N J, Hanna,N M,Henriksen,N A,Blencowe,N S,Merrett,N,Welch,N T,Colucci,N,de'Angelis,N,Latronico,N,Werner,N L,Martin,N D, Machairas,N,Bugaev,N,Pang,N Q,Obinwa,O,Akanji,O O, Kapsampelis,P,DeNardi,P,Vincenzi,P,Kohan,PL,Pucher,PH, Herrod,PJ,CHIU,PW,Marzuillo,P,Sileri,P,Fransvea,P,Navsaria, PH,Valentin,PD,Bakx,R,Choron,R L,Gupta,R,Ivatury,R R, Diaz,R,Bradley,R A,Elisa,R,PalaciosHuatuco,R M,Shahriarirad, R,Rattan,R,Karmy-Jones,R,Sawyer,R G,Coelen,R J,Cirocchi,R, Gelbard,R B,Zakeri,R,Farinha,R,Schols,R M,Dumas,R P, Saverio,S D,Bandyopadhyay,S K,Delibegovic,S,Stevens,S, Navarro,S M,Chatterjee,S,Petousis,S,Gourgiotis,S,Streit,S M, Baral,S,Karna,S T,Moug,S,Yoong,S,Gisbertz,S S,Kheirbek,T, Jeremy,TY-C,Duane,TM,Jensen,TK,Bright,T,Hardcastle,TC, Tania,T,Nikolian,VC,Bianchi,V,Kong,V,Trapani,V,Shelat,VG, Mani,VR,Khokha,VM,Yang,W,Al-Khyatt,W,Lam,YH,Kijima,Y, Cui,Y,Perkins,Z B,Demetrashvili,Z,Ng,Z Q (2024) Novel TextbookOutcomesfollowingemergencylaparotomy:Delphi exercise BJSOpen,8(1) https://doiorg/101093/bjsopen/zrad145

AjayJain,MD 38429478/101038/s41556-024-01372-4/Murthy,D,Attri, K S,Shukla,S K,Thakur,R,Chaika,N V,He,C,Wang, D,Jha,K,Dasgupta,A,King,R J,Mulder,S E, Souchek,J,Gebregiworgis,T,Rai,V,Patel,R J,Hu,T, Rana,S,Kollala,S S,Pacheco,C,Grandgenett,P M, Yu,F,Kumar,V,Lazenby,A J,Black,A R,Ulhannan, S.,Jain,A.,Edil,B.H.,Klinkebiel,D.L.,Powers,R., Natarajan,A,Hollingsworth,M A,Mehla,K,Ly,Q, Chaudhary,S.,Hwang,R.F.,Wellen,K.E.,Singh,P.K. (2024) Cancer-associatedfibroblast-derivedacetate promotespancreaticcancerdevelopmentbyaltering polyaminemetabolismviatheACSS2-SP1-SAT1axis Naturecellbiology.

JeremyJohnson,MD

38295192/101097/PEC0000000000003116/Leiva,T, Golubkova,A,Snyder,K,Johnson,J J,Hunter,C J (2024) PediatricTraumaticLumbarHerniasand AssociatedInjuries:ACaseSeries Pediatricemergency care,40(2),103-107 38189680/101097/TA0000000000004228/Naiditch,J A, Notrica,D.M.,Sayrs,L.W.,Linnaus,M.,Stottlemyre,R., Garcia,N M,Lawson,K A,Cohen,A S,Letton,R W, Johnson,J.J.,Maxson,R.T.,Eubanks,3rd,J.W.,Ryan, M,Alder,A,Ponsky,T A,StPeter,S D,Bhatia,A M, Leys,C.M.(2024).Theuseandtimingofangioembolizationinpediatricbluntliverandspleeninjury Thejournaloftraumaandacutecaresurgery.

AlessandraLandmann,MD 101016/jjpedsurg2024161997/Snyder,K B,Phillips, R,Stewart,K E,Sarwar,Z,Hunter,C J,Landmann,A, Albrecht,R,Johnson,J J (2024) SIPAPoorlyPredicts OutcomesinYoungPediatricTraumaPatients Journal ofPediatricSurgery,161997 http://dxdoiorg/101016/ jjpedsurg2024161997 https://www.avensonline.org/wp-content/uploads/ JSUR-2332-4139-12-0058pdf/Snyder,K B,Farnell,C, Buonpane,C.(2024).OpenRepairofPediatric AortoentericFistulafromARemoteGastricTransposition inCongenitalEsophagealAtresia:AMultidisciplinary Approach JournalofSurgery,12(1),1-3 https:// www.avensonline.org/wp-content/uploads/ JSUR-2332-4139-12-0058pd

MinLi,PhD 101002/adfm202410079/Hoover,A,Liu,K,Furrer,C, Lam,S,Anderson,D,Zhou,Z,Yang,J,Wong,C, Medcalf,A,Sun,X,Hode,T,Alleruzzo,L,Delawder,A, Raker,J,Abousleiman,G,Valerio,T,Sun,Y,Papin,J, Li,M,Chen,W (2024) N-DihydrogalactochitosanDrives ConventionalandAlternativeActivationsofSTINGto SynergizeTypeIIFNandIL-1βProductionsforAntitumor Immunity.ADVANCEDFUNCTIONALMATERIALS. 39688909/101172/jciinsight186565/Fu,H,Cai,Q, Zhou,Z.,He,Y.,Li,M.,Yang,D.(2024).Orthotopicgastric cancermousemodelidentifiestrajectoryoflymphatic metastasis.JCIinsight. 39307410/PMC11471373/101016/jcanlet2024217267/ Liu,K.,Hoover,A.R.,Wang,L.,Sun,Y.,Valerio,T.I., Furrer,C,Adams,J,Yang,J,Li,M,Chen,W R (2024) Localizedablativeimmunotherapyenhancesantitumor immunitybymodulatingthetranscriptomeoftumorinfiltratingGammadeltaTcells Cancerletters,604, 217267

Publications&IntellectualContributions

MinLi,PhD(cont’d)

39217610/PMC11403044/10.1016/j.xpro.2024.103281/ Zhou,Z,Yang,J,Liu,M,Ren,Y,Shi,X,Cai,Y,Arreola, A X,Li,Y P,Zhang,Y,Li,M (2024) Protocolfor establishingandevaluatingacancercachexiamouse model STARprotocols,5(3),103281 38608702/PMC11162958/10.1016/j.ccell.2024.03.009/ Liu,M,Ren,Y,Zhou,Z,Yang,J,Shi,X,Cai,Y,Arreola, A X,Luo,W,Fung,K-M,Xu,C,Nipp,R D,Bronze,M, Zheng,L,Li,Y P,Houchen,C W,Zhang,Y,Li,M (2024) Thecrosstalkbetweenmacrophagesand cancercellspotentiatespancreaticcancercachexia. Cancercell,42(5),885-903e4

38341126/101016/jcanlet2024216722/Li,M (2024) Halfcenturyofcancerresearch:InhonorofDrrernat ManfredSchwab,theformerEditor-in-ChiefofCancer Letters.(vol.585,pp.216722).Cancerletters.

SuhairMaqusi,MD

39220674/PMC11364467/101055/a-2376-7197/ Stevens,B E,Bialek,S,Zhao,K,Maqusi,S,Rassi,E E,Tan,J,Graffeo,C (2024) Profound PneumocephalusandLow-PressureHydrocephalus TriggeredbyVentriculoperitonealShuntPlacement afterResection,FatGraftReconstruction,and RadiotherapyforaMalignantSkullBaseSchwannoma Journalofneurologicalsurgeryreports,85(3),e138e143

LaceyMcNally,PhD

Holter,J.L.(2024).18F-FLTPETandBlood-based BiomarkersforIdentifyingGastrointestinalGraftversus HostDiseaseafterAllogeneicCellTransplantation RadiologyImagingCancer,7,e240096

MacCuaig,W M,McNally,L R (2024) Influenceof structuralmoietiesinsquarainedyesonoptoacoustic signalshapeandintensity Chem,10(2),713-729 Agarwal,H,McNally,L R (2024) Theranostic nanoparticlesfordetectionandtreatmentof pancreaticcancer WileyInterdisciplinaryReviews: NanomedicineandNanobiotechnology,16,e1983.

FernandoMier-Giraud,MD

38869833/101007/s11695-024-07296-0/Martinino,A, NanayakkaraKDL,Madhok,B,WongGYM,Abouelazayem, M,PereiraJPS,Wazir,I,Balasubaramaniam,V,Said,A, Marques,C,Abdelbaeth,A,Al-Shami,K,Albashari,M, Alkaseek,A.,Almayouf,M.A.,Aloulou,M.,Alqahtan,A.R., Askari,A,AttiaMFA,Awad,A K,Aykota,M R,Bacalbasa, N,Barrera-Rodriguez,F J,Benavoli,D,Billa,S,Borrelli, V.,Çalıkoğlu,İ.,Campanelli,M.,Carbajo,M.A.,Chowdhury, S,Cristin,L,Dapri,G,Dong,Z,Elfawal,M H,Elgazar,A, Elhadi,M,Gentileschi,P,Graham,Y,Haj,B,Johnson,J A,Kalmoush,A M,Kamal,A,Kamocka,A,Khamees,A, Lisi,G,HernandezEEL,Marinari,G M,Martines,G,Meric, S.,Mier,F.,Ali,A.M.,Mohammed,D.,Mohamed,K.M., Mulita,F,Musella,M,O'Malley,W E,Olmi,S,Omarov,T, Osama,O,Perera,H R,Piscitelli,G,Poghosyan,T, Ramírez,D.,Rezvani,M.,Ribeiro,R.,Sabbota,A.,Sakran,N., Sawaftah,K A,Schiavone,K,Şen,O,Sotiropoulou,M, Tartaglia,N,Tokocin,M,Trotta,M,Türkçapar,A G, Uccelli,M,Vargas,C,Verras,G,Wang,C,Wei,Z,Yang,W, Zerrweck,C,Owen,E,Gkoutos,G V,Cardoso,V R, Singhal,R.,Mahawar,K.(2024).Global30-DayMorbidity andMortalityofPrimaryBariatricSurgeryCombinedwith AnotherProcedure:TheBLENDStudy Obesitysurgery

MaheswaranPitchaimuthu,MD 39056458/101177/00031348241268273/Pardue,K, Timmerman,M,Elgenaid,S,Hassell,L A,Battula,N R,Pitchaimuthu,M (2024) SuccessfulLiverTransplant FromaDonorWithSickleCellDisease.TheAmerican surgeon,31348241268273

CeliaQuang,MD 10.1016/j.amjsurg.2024.115858/Snyder,K.,Gushing,J., Quang,C,Stewart,K E,Sarwar,Z,Albrecht,R,Blair,S (2024).Propofoladministrationforinductionis associatedwithperi-intubationinstabilityintrauma criticalcareunitpatients AMERICANJOURNALOF SURGERY,238

MatthewJ.Reinersman,MD 38564059/101007/s11701-024-01898-7/Trimble,E J, Stewart,K E,Reinersman,J M (2024) Early comparisonroboticbronchoscopyversus electromagneticnavigationalbronchoscopyforbiopsy ofpulmonarynodulesinathoracicsurgerypractice Journalofroboticsurgery,18(1),149.

JessSchwartz,MD

101201/9781003526384-4/Parasher,G,Schwartz,J D (2024).ComplicationsofEsophagealStentsandTheir Management Self-ExpandingStentsinGastrointestinal Endoscopy(pp.59-76).CRCPress.https:// doiorg/101201/9781003526384-4

KennethStewart.PhD. 101016/jamjsurg2024115858/Snyder,K B,Gushing, J,Quang,C Y,Stewart,K E,Sarwar,Z,Albrecht,R, Blair,S G (2024) Propofoladministrationforinduction isassociatedwithperi-intubationinstabilityintrauma criticalcareunitpatients AmericanJournalofSurgery, 238.https://api.elsevier.com/content/abstract/ scopus id/85199778088

EmilySwitzer,MD

10.1177/00031348241256084/Sullivan,B.G.,Delaplain, P T,Manasa,M,Tay-Lasso,E,Biffl,W L,Schaffer,K B, Sundel,M.,Behdin,S.,Ghneim,M.,Costantini,T.W., Santorelli,J E,Switzer,E E,Schellenberg,M,Keeley,J A,Kim,D Y,Wang,A,Dhillon,N K,Patel,D,Campion, E M,Robinson,C K,Kartiko,S,Quintana,M T,Estroff, J M,Kirby,K A,Nahmias,J (2024) AnAbdominalSeat BeltSignisAssociatedWithSimilarIncidenceofHollow ViscusInjurybutIncreasedIn-HospitalMortalityinOlder AdultTraumaPatients:APCSAMulticenterStudy The Americansurgeon,90(11),2840-2847 https:// api.elsevier.com/content/abstract/ scopus id/85206018200

FrankWood,MD

Wood,F.C.(2024).SCORESchool:AirwayAccess, Intubation,andSurgicalAirways TheSCOREPortal http://www.surgicalcore.org

Events

2024ChiefResidentFarewellBreakfast

ChristopherJeffery,MD

PlasticSurgeryFellowship UniversityofOklahoma OklahomaCity,OK

ConnorWilkinson,MD PrivatePractice

GeneralSurgery ComancheCounty MemorialHospital Lawton,OK

TaylorWilkinson,MD ColorectalSurgery Fellowship UniversityofTennessee Chattanooga,TN

LilyNguyen,MD PrivatePractice

GeneralSurgery CollegeStation,TX

SamaraLewis,MD

PrivatePractice

GeneralSurgery Topeka,KS

2024ChiefSurgicalResidents&Fellows

GraduationBanquet

2024ChiefSurgicalResidents&Fellows

GraduationBanquet

2024 StaffCelebrations

2024Christmas

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Issue 9 Year in Review

DEPARTMENT OF SURGERY

2024YEAR INREVIEW

Letter from the Chair

TABLEOFCONTENTS

Whenthemissionispure,itmakestheworkeasier

2024NewFaculty

AcademicFaculty

AdministrativeStaff

AcademicFaculty

PredictHeartValveLeakageinChildren

forLungCancerSurgery

CreatineSupplementation

ProtectingtheBarrier

HyaluronicAcidandProteins

OUHealthHelpsWomanRecoverAfterExplosiveCrash

FirstLiverTransplantforAggressiveCancerAchievedatOUHealth

TheMostChallengingofAllCancers

OUHealthMakesHistoryinOklahoma

Message from Dr. Jain

Health Joins an Elite Group of Cancer Transplant Programs - First Liver Bile Duct Cancer in Oklahoma~

‘A Special Angel in Live’ - OUHealthTransplantInstituteSavesLives

Coordinators

AcademicFaculty

LeesNamedAssociateDeanofGraduateMedicalEducation

OUCollegeofMedicineAppointsNewAssistantDeanstoLeadGraduate MedicalEducationProgram

AcademyofTeachingScholars

PancreaticCancer

LiservesasPresidentofAmericanPancreaticAssociation

ResearchersDiscoverCell‘Crosstalk’ThatTriggersCancerCachexia

Awards/Honors

Grants/Research

Grants/Research

Grants/Research

Grants/Research

Presentations

Presentations

Presentations

Publications& IntellectualContributions

Publications&IntellectualContributions

Publications&IntellectualContributions

Publications&IntellectualContributions

Events

2024ChiefResidentFarewellBreakfast

2024ChiefSurgicalResidents&Fellows

GraduationBanquet

2024ChiefSurgicalResidents&Fellows

GraduationBanquet

2024 StaffCelebrations

2024Christmas