Issue 9 Year in Review

DEPARTMENT OF SURGERY

2024 YEAR IN REVIEW

ISSUE 9

Letter from the Chair Welcome to the Department of Surgery Newsletter!

This issues covers 2024 as we share the incredible basic science, translational science, and clinical innovation our department Address

faculty are contributing to academic surgery. As the field of surgery evolves, so does our department and we highlight the

Department of Surgery Andrews Academic Tower 800 Stanton L. Young Blvd #9000 Oklahoma City, OK 73104

amazing accomplishments. During 2024, we continued to excel with our missions, grew as a department, and added to our individual accomplishments.

Phone

We are constantly striving to improve and innovate which keeps us at the forefront in the world of surgical advancements. I hope that you enjoy looking through all the events, but, most importantly, take pride, as I did, in our many accomplishments in 2024.

(405) 271-7912 Office (405) 271-3919 Fax

Email barish-edil@ou.edu

Finance | Administration Jessica Capetillo Executive Assistant / Senior Administrative Manager Katherine White Executive Assistant II Amber Rice Department Surgery Scheduler Marlow Brooks OUHSC IT Analyst Lisa Suriano Senior Clinical Business Administrator

I would like to thank the entire department for your poise, patience, and perseverance as our academic landscape is continually shifting. I am extremely proud of your leadership, academic vigor, and dedication to our students and residents.

Finally, I would like to congratulate our graduates who will continue OU Surgery’s legacy as they begin their fellowships and practices.

Thank you for your interest in our newsletter and I hope you find it informative.

Sincerely,

Heather Dees Accountant Manager Mary Sheets Senior Accountant Marlo Southerland, SHRM-CP Lead Administrative/Finance Coordinator

Barish H. Edil, MD Professor & Chair

https://medicine.ouhsc.edu/academic-departments/surgery

TABLE OF CONTENTS

ACUTE CARE SURGERY & BURNS CARDIAC, THORACIC & VASCULAR SURGERY GENERAL SURGERY PEDIATRIC SURGERY PLASTIC & RECONSTRUCTIVE SURGERY SURGICAL ONCOLOGY TRANSPLANT SURGERY EDUCATION RESEARCH

When the mission is pure, it makes the work easier -Barish Edil

Mission To improve the health of all people, to deliver excellent, innovative patient care, advance the science of surgery and to educate health professionals, physicians, and surgeons for the future.

Vision

Values

Leading the nation as a Top Tier Department of Surgery

Excellence, Integrity, Collegiality, Compassion

2024 New Faculty

Paulo Martins, MD Associate Professor Transplant Surgery

Jason T. Cheng, MD Assistant Professor Transplant Hepatologist

Bradley Phillips, MD Assistant Professor Acute Surgery Care & Burns

Taylor Martin, MD Assistant Professor Acute Surgery Care & Burns

Arthur Grimes, MD Assistant Professor Acute Surgery Care & Burns

Nana Toyoda, MD Assistant Professor Cardiac, Thoracic & Vascular Surgery

Paul McGaha, MD Assistant Professor Pediatric Surgery

Shinobu Itagaki, MD Assistant Professor Cardiac, Thoracic & Vascular Surgery

Neil M. Venardos, MD Assistant Professor Cardiac, Thoracic & Vascular Surgery Muhammad Panezai, MD Transplant Nephrologist

Academic Faculty Scott Blair, DO Assistant Professor

Bradley Phillips, MD Associate Professor

Morgan Bonds, MD Assistant Professor

Celia Quang-Blair, MD Assistant Professor

Alisa Cross, MD Associate Professor Arthur Grimes, MD Assistant Professor

Emily Switzer, MD Assistant Professor Frank Wood, MD Assistant Professor

Taylor Martin, MD Assistant Professor Chance Nichols, MD Assistant Professor

***Emeritus*** Roxie Albrecht, MD Tenured Professor

Administrative Staff Jessica Capetillo Sr. Administrative Manager Leslie Masse Administrative Assistant

ACUTE CARE SURGERY & BURNS

Jason S. Lees, MD, FACS Robert D. Gordon, Jr. Professor of Surgery Section Chief Acute Care Surgery & Burns Associate Dean of Graduate Medical Education-Designated Institutional Official Vice Chair of Education OU College of Medicine | OU Health Department of Surgery

New Adult Trauma Medical Director - Dr. Alisa Cross

After the retirement of our long-time trauma leader - Dr. Roxie Albrecht, Dr. Alisa Cross has dutifully served as the interim Trauma Medical Director for our state’s only ACS Verified Adult Level I Trauma Center. Since then, Dr. Cross has successfully led our 2023 re-verification review, for which we were commended for our compliance and quality by the ACS. Additionally, she has begun to position our program strategically to improve our quality, increase education and outreach initiatives, and grow our clinical volume.

Please congratulate Dr. Alisa Cross as our new Adult Trauma Medical Director. In this role, she will continue this work while collaborating with our growing core of clinical leaders and triad partners.

Dr. Cross is a native of Tulsa, Oklahoma. She graduated AOA from the OU College of Medicine in 2006, completed her residency in general surgery at Emory University and Grady Memorial Hospital, followed by a trauma/CC fellowship under Dr. David Feliciano at the same institution. Following a brief stint in Pittsburg at Allegany Health where she

Emily Switzer, MD

served as associate residency director, we were fortunate to recruit her to the Department of Surgery where she quickly established herself with her dedication to education, interest in health systems care delivery, and clinical excellence.

During this time she started our surgical initiative care service line which supports the surgical care of all surgical departments and carries one of the highest case mix indices of any of our patient care units. She has published and written chapters around all facets of acute care surgery and is active in the Western Trauma Association. Educationally, she has mentored dozens of medical students and residents to successfully reach the next phase of their professional development, served nationally on the American Board of Surgery’s SCORE steering committee, and contributed to many peer reviewed trauma references and chapters. Within our state, she serves on the Oklahoma’s Trauma and Emergency Response Advisory Council and is Vice Chair of Oklahoma’s American College of Surgeons Committee on Trauma. Most importantly amongst all mentioned, she is a dedicated mother to sons Levi and Benjamin.

Congratulations Dr. Cross as we look forward to the next leader in trauma surgery in our state!

Announcing the First OU Health Way Champion Award Winners -Story provided by OU Health | OU Division of Marketing and Communications

The OU Health Way Champion Award is a prestigious accolade that celebrates the exceptional contributions of our physicians and team members.

We want to celebrate those who embody the essence of the OU Health Way and uphold our core values: Patients First, Relentless Excellence, Integrity, Inclusion, Teamwork, and Learning.

It's an opportunity for us to acknowledge and appreciate those who play a pivotal role in fostering a culture that aligns with our vision and positively impacts the lives of our patients and fellow team members.

The OU Health Way Champion Award was introduced in October 2023 and we received 83 nominations!

Emily Switzer, MD

Physician OU Health Way Champion: Emily Switzer, M.D. Emily Switzer, M.D., is a trauma surgeon at OU Health. Her nomination said she displays relentless excellence each and every day by bringing a positive attitude and a desire to change our program and policies for the better.

Dr. Switzer “is constantly working on ways to improve patient safety and has spearheaded many necessary changes in our ICUs that have already had positive patient outcomes. She is collaborative and values others’ ideas on projects. Dr. Switzer is truly an asset to our institution and embodies all of the values of the OU Health Way,” the nomination read.

Congratulations, Dr. Switzer! Thank you for all you do for your patients, team, and community. You’re an outstanding example of the OU Health Way and our core values.

CITATION: Announcing the First OU Health Way Champion Award Winners (2023, November). https://hub.ouhealth.com/ce/pulse/user/content/search? search_page=beta_search_home_page&keyword=switzer&isSearchFullNetwork=true

Chief of Pediatric Cardiothoracic Surgery CMRI Brandon Weeden Chair Surgeon-in-Chief, OCH Surgical Director,CICU Okalhoma CHildren’s Hosptial

Academic Faculty Benjamin Chou, DO Assistant Professor

J. Matthew Reinersman, MD Associate Professor

Joshua Gierman, MD Associate Professor

Jess Schwartz, MD Associate Professor

Benjamin Greif, MD Associate Professor

Nana Toyoda, MD Assistant Professor

Shinobu Itagaki, MD Assistant Professor

Neil Venardos, MD Assistant Professor

Administrative Staff Jennifer Burks Administrative Manager Shelly Jones Administrative Coordinator Nashona Ragland, Administrative Manager Pediatric Cardiothoracic Surgery

CARDIAC, THORACIC & VASCULAR SURGERY

Harold M. Burkhart, MD Professor and Chief Division of Cardiac, Thoracic & Vascular Surgery Paul H. and Doris Eaton Travis Chair OU College of Medicine | OU Health Department of Surgery

Multidisciplinary Research Team Creates Computational Models to Predict Heart Valve Leakage in Children -Story provided by OU Health | OU Division of Marketing and Communications

An innovative new field of research holds the promise for pediatric cardiologists and heart surgeons to predict the future structural integrity of a child’s heart valves so they can perform the best possible surgery today.

At the University of Oklahoma, a pediatric heart surgeon and cardiologist are collaborating with a biomedical engineer in a type of research that few in the nation are doing. By leveraging the expertise and technology of their respective fields, they are creating computational models to help them more fully understand the intricacies of individual hearts. Whereas traditional imaging techniques like echocardiogram provide a picture of the heart in motion, a computational model offers a simulated view of the shape of the valves, possible weak spots, the blood moving through the valves, and potential surgical steps to prevent future problems.

“This is truly translational medicine,” said OU Health pediatric heart surgeon Harold Burkhart, M.D., who is also a professor and chief of cardiovascular and thoracic surgery in the OU College of Medicine.

“Because of our multidisciplinary collaboration, we have the knowledge together to Harold Burkhart, MD create a computational model that goes beyond what we are able to see with both 2D and 3D echocardiogram. It allows us to go a step further and visualize the heart as it would be in real life with the characteristics of each individual,” Burkhart said. “With that understanding, we can test what would happen if we put a stitch here or tighten a valve there — does it put too much stress on the valve, or does it address the problem? It can potentially give us a lot more direction before we even go into the operating room.”

The research group began their studies with hypoplastic left heart syndrome, a severe birth defect in which the left side of a baby’s heart does not form correctly and cannot pump blood well, leaving the right side of the heart to pump blood to the lungs and the rest of the body. Without a set of three of open-heart surgeries to repair the defect, the condition is often fatal. While continuing those studies, they are now developing computational models for atrioventricular canal defect, sometimes called a hole in the heart, because the baby is born with a hole in the wall separating the heart’s chambers.

While surgeries for both conditions are often successful, children sometimes face a risk of re-operation in the future because of leaky valves, Burkhart said. In hypoplastic left heart syndrome, about 25% of patients have leaky valves by the time they are in preschool. Babies with atrioventricular canal defect sometimes experience valve leakage six months to two years after the initial surgical repair, for reasons that are not yet understood. Follow-up surgeries are about half as successful as the original procedure, and if the repair can’t be made, the child may need a mechanical heart valve, which comes with its own set of risks and complications.

During surgery, when the heart is stopped and on a bypass machine, it lays flat and doesn’t maintain its structure as it would if it were pumping blood. Surgeons employ techniques to inflate the valves to improve their view, but heart surgery is time-limited and allows for no trial and error. If a computational model can predict which areas of the heart valves could become problematic, surgeons may be able to take steps to prevent that leakage in the future.

“Even with 3D echocardiogram, it’s hard to see the finer details of the valves,” said OU Health cardiologist Arshid Mir, M.D., an associate professor of pediatric cardiology in the OU College of Medicine. “Most heart valves are like Pringle chips — they are more angular and have high and low points. We want to learn about these valves and try to predict which valves, right at birth, would have a risk of becoming leaky when the child is between 1 and 5 years old, so that we can try to address them surgically at the time of the first repair.

“What we are doing is moving toward personalized medicine,” Mir added. “How do we think about each patient differently rather than thinking of a condition as a single disease? What is unique about this child’s anatomy that makes him at higher risk for re-operations? This is the way we will be thinking about these diseases as we head into the future.”

Burkhart and Mir work with Chung-Hao Lee, Ph.D., a former OU biomedical engineering researcher now at the University of California, Riverside. He builds computational models that draw from the fields of physics, fluid dynamics, geometry and bioengineering to create something that hasn’t existed before. Burkhart and Mir provide 2D and 3D echocardiograms of patients enrolled in the studies for the calibration of the models and for model prediction. They will continue to gather data from patients at multiple time points over the next several years.

Arshid Mir, MD

“Through this image-based computational model, we want to provide the missing information — which patients will have valve dysfunction,” Lee said. “If we can better understand which valves have weak spots and may start leaking, surgeons may plan their surgeries differently and cardiologists may want to monitor or follow the patient more closely after surgery.”

Thus far, the research team has published about 10 papers on their computational modeling for hypoplastic left heart syndrome and recently published a paper on atrioventricular canal defect in the Annals of Biomedical Engineering.

About the project The research team’s latest paper, “Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves,” is at The research team’s latest paper, “Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves,” is at .

The research has been supported by the Presbyterian Health Foundation in Oklahoma City, the American Heart Association, the Oklahoma Center for the Advancement of Science and Technology, and the National Institutes of Health.

CITATION: Multidisciplinary Research Team Creates Computational Models to Predict Heart Valve Leakage in Children (April 16, 2024). OU Medicine A bold step forward Winter 2024- 2025 Newsletter, pg 27. https://www.ou.edu/news/articles/2024/april/research-team-creates-computationalmodels-to-predict-heart-valve-leakage-in-children

OU Health Surgeons First in Oklahoma to Use ‘Glowing’ Imaging Agent for Lung Cancer Surgery -Story provided by OU Health | OU Division of Marketing and Communications

OU Health has become the first health system in Oklahoma to utilize an innovative new imaging agent that causes lung cancer cells to glow during surgery. This marks a significant advancement in lung cancer treatment for the state, with the potential to improve surgical outcomes and recovery times for patients.

The fluorescent imaging technology, called Cytalux, binds to cancerous tissue when administered prior to surgery, making it easier for surgeons to completely remove tumors while sparing healthy tissue.

"This technology allows us to visualize cancer that might otherwise be difficult to detect. For lung cancer patients, it means we can perform less invasive surgeries with more precision, potentially leading to faster recoveries and better outcomes,” said thoracic surgeon Dr. J. Matthew Reinersman, M.D., FACS, Chief of Section of Thoracic and Foregut Surgery in the Department of Surgery at the University of Oklahoma College of Medicine.

Matthew J. Reinersman, MD

A 69-year-old patient, who had a small lung nodule discovered during imaging for a shoulder injury, underwent the procedure successfully in September 2024. "His tumor was completely removed with negative margins, and no lymph nodes were involved. He is cancer-free and will not require any other treatment such as chemotherapy or radiation," Dr. Reinersman said.

More than 130,000 Americans die of lung cancer each year, making it the leading cause of cancer death in the United States. Lung cancer is often diagnosed late, when it has already begun to spread. In Oklahoma, more than 3,200 people are diagnosed with lung cancer each year, and nearly 16% of those patients will undergo surgery as a first course of treatment, according to the American Lung Association.

"This technology not only helps us with primary lung cancers but also with identifying spread of cancer from other sites to the lung," Dr. Reinersman added. "It's a game-changer for how we approach certain cancer surgeries."

On Target Laboratories, Inc., a privately held biotechnology company based in West Lafayette, Indiana received approval for Cytalux in November 2021 by The U.S. Food and Drug Administration (FDA) for use in adult patients with ovarian cancer. In December 2022, the FDA expanded its approval to include use in adult patients with known or suspected lung cancer.

CITATION: OU Health. 14 Nov 2024, https://www.ouhealth.com/blog/2024/november/ou-health-surgeons-first-in-oklahoma-to-use-glow/ #~ce56ae54-eaa4-4ba0-9077-6aeccd154a2b

Academic Faculty Catherine Hunter, MD Professor / Section Chief Jeremy Johnson, MD Associate Professor Alessandra Landmann, MD Assistant Professor Paul McGaha, MD Assistant Professor

Administrative Staff Susan Cloer Finance/Administrative Coordinator

PEDIATRIC SURGERY

Catherine J. Hunter, MD, FAAP, FACS Professor of Surgery Chief of Pediatric Surgery Program Director of Pediatric Surgery Edith Kinney Gaylord Presidential Professor Paula Milburn Miller Chair in Pediatric Surgery Oklahoma Chilren’s Hospital OU College of Medicine | OU Health Department of Surgery

Multidisciplinary Research Team Creates Computational Models to Predict Heart Valve Leakage in Children -Story provided by OU Health | OU Division of Marketing and Communications

In the past year, three researchers at the University of Oklahoma College of Medicine at OU Health Sciences have earned more than $5 million in grant money to study causes and potential treatments for necrotizing enterocolitis, a deadly intestinal disease that primarily affects infants born prematurely. Because NEC occurs suddenly and progresses rapidly, research is crucial for giving the most fragile babies a chance at life.

About 7% of all preterm babies are diagnosed with NEC, which occurs when the baby’s underdeveloped small intestines have an excessive reaction to naturally changing bacteria. Unless NEC can be stopped, the lining of the intestinal wall becomes nflamed, and the intestines can rupture or die. In about 30% of cases, the infant dies, often hours or days after diagnosis. For preterm babies who are born weighing 2 pounds or less, the risk of death with NEC is as high as 50%. The babies who survive often face problems with growth, nutrition, walking and cognitive development. The growing NEC research program at the OU College of Medicine is tackling NEC from multiple angles.

Catherine Hunter, MD

“This is an exciting time for NEC research in the OU College of Medicine because we are increasing the number of investigators focused on the disease, and our projects represent several disciplines in pediatrics,” said Hala Chaaban, M.D., director of clinical and translational research in the college’s Department of Pediatrics, Section of Neonatal-Perinatal Medicine.

Chaaban, a neonatologist, is one of the three researchers in the OU College of Medicine who recently earned local, state and federal funding to study NEC. The other two are pediatric surgeon Catherine Hunter, M.D., Section Chief of Pediatric Surgery, and scientist Kathryn Burge, Ph.D., in the Section of Neonatal-Perinatal Medicine. Each leverages her unique vantage point in a variety of innovative research projects.

Hala Chaaban, MD

Creatine Supplementation Burge’s latest grants fund her focus on creatine. This natural compound is known for its ability to strengthen the intestinal barrier so that bacteria can’t cross it easily, as well as for supplying energy to intestinal cells. Because creatine accumulates in the fetus during the third trimester of pregnancy, babies born prematurely don’t receive enough of the nutrient from their mothers.

And infants are not able to replenish their supply, even though creatine is present in breast milk in low levels. In her laboratory, Burge is testing tissues to determine whether creatine levels are low or drop suddenly before NEC develops.

“We will also be treating our cell-based models with creatine to see whether they are more resilient to NEC,” Burge said. “NEC doesn’t usually affect babies right after birth; it occurs several weeks later. So, we are studying the possibility of supplementing with creatine in the window before NEC develops. Can we give creatine and build it up to the level it should have been and therefore prevent NEC?”

Kathryn Burge, PhD

Burge’s research is funded by the National Institutes of Health and the Oklahoma City-based Presbyterian Health Foundation. Her newest NIH grant establishes her as an independent researcher.

Protecting the Barrier As a pediatric surgeon, Hunter may remove dead portions of the intestine if antibiotics and nutrition fail to help a baby with NEC. Surgery is tricky — she must determine the best time to operate to preserve as much intestine as she can, yet not perform unnecessary surgeries on small and fragile babies.

“Unfortunately, many babies with NEC require surgery, and after surgery, mortality rates are very high. If they do survive, their chances of needing an intestinal transplant down the road are high, and that is not ideal,” Hunter said. “As a scientist, I want to develop strategies to prevent NEC. I’d rather babies not ever get to the point where they need me as a surgeon.”

Hunter’s research centers on the intestinal barrier, which keeps bacteria from entering the bloodstream. In particular, she is studying a specific signaling pathway called ROCK that acts like a zipper to keep the intestinal barrier strong. In the development of NEC, something happens in the ROCK pathway to weaken the intestinal barrier.

“In our lab, we have discovered that ROCK is activated during the development of NEC and that inhibiting ROCK appears to protect some of the intestinal barrier function,” Hunter said. “This new grant will allow us to continue studying this pathway to better understand its potential in preventing NEC. Not every premature baby develops NEC, but this research may help us better understand why some are more susceptible to the condition.”

Hunter has received funding from the NIH and the Oklahoma Center for Adult Stem Cell Research. She is among a small group of surgeons nationwide to receive an NIH R01 grant, considered the gold standard in research funding.

Hyaluronic Acid and Proteins One of Chaaban’s longtime research areas is hyaluronic acid in human breast milk, which is beneficial for the development of a baby’s intestines. Because preterm babies begin their lives with underdeveloped intestines, they don’t receive the same benefits from hyaluronic acid as term babies do. Chaaban’s research has shown that additional doses of hyaluronic acid in mice help the intestines mature more rapidly and protect from intestinal injury like NEC would cause.

Chaaban’s new R01 grant from the NIH will allow her to continue studying the role of hyaluronic acid in human breast milk and whether supplementation in preterm babies might one day be possible to prevent NEC. An additional research focus, funded by a subcontract through the federal government’s Small Business Innovation Research program, is a group of proteins made in the body called inter-alpha inhibitor proteins, or IAIP, which protect against inflammation. Babies with NEC have lower levels of IAIP, putting them at risk for problems. Chaaban is testing whether giving additional IALP reduces inflammation and the chance of multi-organ failure in mouse research models.

“IAIP appears to calm down the body,” she said. “In babies with NEC, their bodies are trying to protect themselves, but they are not mature enough to differentiate between what is bad and what is good, so their immune system basically kills all the cells, and their organs begin to fail. Giving IAIP appears to be a way to quiet down the body’s inflammation.”

Chaaban and fellow OU College of Medicine neonatologist Birju Shah, M.D., are working with a company called ProThera Biologics to test a rapid diagnostic tool that can be used at the bedside to measure levels of IAIP. Results would be available within 10 minutes, allowing doctors to act quickly. After Phase 1 and 2 clinical trials testing the device, it appears promising.

Because Oklahoma Children’s Hospital OU Health offers the highest level of neonatal intensive care and around-theclock surgical coverage, it treats most babies in the state with NEC. Complementing that expertise with research will improve the care that babies receive.

“I love taking care of patients and families and having those individual relationships,” Hunter said, “but science gives us the opportunity to have a wider impact and maybe even make a positive change for an entire population of patients.

Research is incredibly important.”

CITATION: OU College of Medicine Researchers Earn Over $5 Million to Study Deadly Disease That Affects Premature Babies (2024, January). https:// www.ouhsc.edu/news/details/ou-college-of-medicine-researchers-earn-over-5-million-to-study-deadly-disease-that-affects-prematurebabies

Vivian’s Gastrointestinal Issues Don’t Slow Her Down Thanks to Complex, Ongoing Care -Story provided by OU Health | OU Division of Marketing and Communications

When Vivian Bodenhamer was born full-term in 2014, her parents had no idea of the medical journey ahead. At just 6 weeks old, Vivian wasn’t eating like a typical infant. Her mother, Miranda Bodenhamer of Norman, noticed something wasn't right.

"She was vomiting whenever she would eat, like, projectile vomiting," Miranda said. "I would be breastfeeding her, and she would vomit, and it would hit the wall behind me. I had three other kids, three older boys, and none of them did that, so I really knew something was not right.”

After initial tests at a local hospital, Vivian was quickly transferred to Oklahoma Children's Hospital OU Health for more complex tests. Doctors discovered she had a severe urinary tract infection (UTI) and neurogenic bladder, a condition where the bladder doesn't empty properly.

But the vomiting persisted, leading doctors to suspect a bowel obstruction. Her doctors, Dr. M. Adnan Altaf, M.D., FAAP, a pediatric gastroenterologist with Oklahoma Children's Hospital and Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition at the University of Oklahoma College of Medicine, and Dr. Jeremy Johnson, M.D., a pediatric surgeon at Oklahoma Children's Hospital and Associate Professor in the Department of Surgery at the OU College of Medicine, found no physical obstruction.

"They were like, ‘She's a medical mystery,'" Miranda said.

Rare Diagnosis: Chronic Intestinal Pseudo-Obstruction After weeks of testing and observation, Vivian was diagnosed in October 2014 with chronic intestinal pseudo-obstruction. This complex disorder affects the movement of food through the digestive system, mimicking the symptoms of a physical obstruction without any actual blockage. Intestinal pseudo-obstruction presents unique challenges in diagnosis and treatment, as each case can vary significantly.

"Basically, the entire GI tract doesn't work for processing food. Normally, your stomach and intestines squeeze in a coordinated way so that food goes through, and you digest it,” Dr. Johnson said. “But for her, it does not happen, which prevents her from being able to eat."

Jeremy Johnson, MD

To ensure Vivian received proper nutrition, her care team at Oklahoma Children's Hospital implemented a crucial intervention. "The only way for her to grow and get nutrition was IV nutrition, so she had to have a special catheter placed to receive IV nutrition at home," Dr. Johnson said.

This method of nutrition has been a constant in Vivian's life since infancy. Over the years, Vivian's case required multiple interventions and careful management. In January 2023, Vivian's condition worsened, and she underwent a significant surgical intervention in the form of a diverting ileostomy.

"Think of the intestines as like a garden hose that goes from one end to the other,” said Dr. Johnson. “When you make an ostomy, you cut that garden hose in half and bring the end that water is flowing through – in this case, it's waste – up to the skin, through the abdominal wall. The bag is just there to catch it, so you don't make a mess."

Four days after the surgery, however, Vivian’s bowel perforated, and she went septic. Dr. Johnson came in on his weekend off to do the surgery. She stayed for three weeks in the ICU while her health team remained unwaveringly involved in her recovery.

"The ICU doctors were amazing. Dr. Johnson would come by and check on us as did Dr. Atlaf and everybody," Miranda said. Despite these challenges, Vivian approaches life with remarkable spirit.

"She's just your typical 10-year-old," Miranda said. "She does ballet, and she does virtual school. She has three older brothers and gives them heck."

Vivian refers to her medical devices as her "accessories," and her resilience allows her and her family to enjoy life, even taking a cruise to Honduras and Mexico recently. Her vivacious nature impresses her doctors as well.

"She doesn't really have any limitations,” said Dr. Johnson. “She can still be whatever she wants to be. I think she’s amazing because she keeps such a positive attitude and has an amazing sense of humor that makes everything easier.

The Importance of Specialized Care Dr. Atlaf emphasizes the unique nature of Vivian's case, noting that the complexity of her condition requires constant reevaluation and personalized care. While Vivian's condition presents ongoing challenges, her family remains hopeful.

"It's a multidisciplinary disorder that needs multidisciplinary management with the involvement of various specialists, including surgeons, urologists, radiologists, and GI specialists,” said Dr. Atlaf. “Oklahoma Children's Hospital stands out as one of the few centers equipped to handle such complex cases.”

For now, Vivian continues to thrive with the support of her family and the Oklahoma Children’s Hospital team.

"She's spunky and spicy and sassy," Miranda says proudly. "If you saw her on the street, you wouldn't know anything was wrong with her."

From specialized GI care to dedicated ICU teams, Oklahoma Children’s Hospital handles complex, long-term pediatric cases with expertise and compassion. For the Bodenhamer family, the short 30-minute drive from Norman made seeing the specialists even easier.

"Everybody at Children's is so amazing," Miranda said. "When you're there for six weeks, you get to know the nurses, and you develop relationships that are just super special. One of the nurses even named her new baby Viviana after Vivian. You just get so close to all the doctors and nurses at Oklahoma Children’s Hospital."

CITATION: Vivian’s Gastrointestinal Issues Don’t Slow Her Down Thanks to Complex, Ongoing Care. (2024, November). https://www.ouhealth.com/ blog/2024/november/no-limitations-vivian-s-gi-issues-don-t-slow-her/#~ce56ae54-eaa4-4ba0-9077-6aeccd154a2b

Academic Faculty

Administrative Staff

Guilherme Barreiro, MD Assistant Professor

Magali Ochoa Administrative Assistant

Christian El Amm, MD Professor Mark Mims, MD Assistant Professor

PLASTIC & RECONSTRUCTIVE SURGERY

Suhair Maqusi, MD, MSs Associate Professor of Surgery Section Chief of Plastic and Reconstructive Surgery Plastic & Reconstructive Surgery Fellowship Director OU College of Medicine | OU Health Department of Surgery

OU Health Helps Woman Recover After Explosive Crash -Story provided by OU Health | OU Division of Marketing and Communications

A Blanchard couple, Joey and Dustin Pettijohn, are recovering at home after a distracted driver hit their Jeep, causing severe burns that required multiple surgeries and a month-long hospital stay. Joey Pettijohn was treated by the skilled team at OU Health, including plastic surgeon Dr. Guilherme Barreiro, M.D., and trauma burn coordinator Denni WilsonLowber, who have been instrumental in her recovery, addressing both the physical and psychological toll of her injuries.

Despite the severity of her burns, Joey is grateful to be alive and is slowly resuming normal activities, cherishing moments with her husband and family.

Plastic surgeons at OU Health work on some of the most painful and damaging injuries.

They strive to restore some aspects of normalcy to patients’ lives while healing their sense of hope.

A routine action, like a walk in the park with the grandkids, can feel like a miracle after several weeks inside a hospital. Joey Pettijohn and her husband Dustin absorbed every moment and every ray of sunlight because everything nearly went dark.

“It’s very nice to get out,” said Joey Pettijohn, walking with her family at Lions Park in Blanchard. Last May, near Blanchard, a distracted driver hit Pettijohn’s Jeep and it exploded.

“We had slowed down to turn, and some kid just wasn’t paying attention,” Pettijohn said. Few words can describe their injuries. The Pettijohn’s were left with third-degree burns that required several surgeries and about a month in the hospital.

Guilherme Barreiro, MD

“That’s the worst part – the after,” Dustin Pettijohn said. OU Health trauma burn coordinator Denni Wilson-Lowber's team treats complex injuries. “Probably the most painful thing you would endure,” Wilson-Lowber said. Joey Pettijohn’s injuries landed her at OU Health – a level one trauma center – where Plastic Surgeon Dr. Guilherme Barreiro went to work.

“The responsibility is something that actually touches you,” Barreiro said. “You feel like you are giving back.”

These doctors and nurses help heal the body and the mind. Wilson-Lowber said the psychological toll from burn injuries can be just as detrimental to a patient. “It’s very emotional,” Wilson-Lowber said. Their efforts brought the Pettijohn family back together. “We’ve learned how to help each other out,” Pettijohn said. Life moves slower, but they’re grateful they’re living life again. Pettijohn refused to live in fear so, she bought another Jeep.

“If you ride a horse and you fall off, you get right back on,” she said. “We’re gonna keep going.” Pettijohn said she has shifted her perspective so she could see the miracles all around her. “Don’t take things for granted,” Pettijohn said.

The Pettijohns have a long recovery ahead with the severity of their injuries, but they have healed the way doctors hoped so far. Pettijohn said she encourages other drivers to be mindful on the road and pay attention.

CITATION: 9News, Jordan Fremstad, OU Health Burn Unit Helps Blanchard Couple Recover After Explosive Crash. (2024, July). https://www.news9.com/story/66a0fa920eabe0b734e6fe42/ou-health-burn-unit-helps-blanchard-couple-recover-after-explosive-crash

Fourth Cohort of Ukrainian Physicians Visit Oklahoma to Train -Story provided by OU Health | OU Division of Marketing and Communications

OU Health recently welcomed its fourth cohort of Ukrainian physicians for a fourweek surgical training program. The program aims to equip these physicians with advanced techniques to treat severe war-related injuries, particularly those affecting the head and neck. Led by Mark Mims, M.D., the program has expanded to include neurosurgeons and a neurologist. The visiting physicians shared the challenges they face in Ukraine due to war-related injuries, and the initiative aims to enhance their expertise and provide unwavering support.

During the program, the Ukrainian surgeons observed and refined their skills under the guidance of OU Health’s expert team. An important aspect of the training involved using technologically advanced glasses donated by Ohana One, which allow U.S.-based physicians to "see" into the operating rooms with the cohort when they return to Ukraine. This innovative approach enables remote assistance and collaboration between the surgeons.

Mark Mims, MD

Dubbed "Operation Ukraine," this program is part of OU Health's ongoing collaboration with the American Academy of Facial Plastic and Reconstructive Surgery. It is supported by organizations such as Razom for Ukraine, INGenuis, and Sooner Hope for Ukraine. The program aims to enhance medical knowledge and skills through international exchange and continues to have a significant impact on medical care in Ukraine.

"Multiple rounds of surgeons have come to OU Health at regular intervals. This is our fourth group to visit, and we aim to ensure the availability of these advanced techniques across Ukraine and contribute to the development of a sustainable model of care for head and neck trauma."

CITATION: Fourth Cohort of Ukrainian Physicians Visit Oklahoma to Train at OU Health (2024, October). https://hub.ouhealth.com/ce/pulse/user/content/search? search_page=beta_search_home_page&keyword=mark+mims&isSearchFullNetwork=true

Academic Faculty Kristina Booth, MD Associate Professor

Fernando Mier, MD Assistant Professor

Steven Carter, MD Assistant Professor

Alexander Raines, MD Associate Professor

Juan Claros-Sorto, MD Assistant Professor

Teresa Shavney, MD Assistant Professor

Barish Edil, MD Professor

***Emeritus*** Ronald Squires, MD Tenured Professor

Administrative Staff Jessica Capetillo Sr. Administrative Manager Leslie Masse Administrative Assistant Brooke Theriault Administrative Assistant

SURGICAL ONCOLOGY

Ajay Jain, MD, FACS Professor and Chief, Division of Surgical Oncology The G. Rainey Williams Chair in Surgical Research Program Director, General Surgical Residency Oklahoma State Chair American College of Surgeons Commission on Cancer OU College of Medicine | OU Health Department of Surgery Department of Surgery

First Liver Transplant for Aggressive Cancer Achieved at OU Health OU Health Becomes Only Center in Oklahoma to Offer Liver Transplants for Bile Duct Cancer -Story provided by OU Health | OU Division of Marketing and Communications

In May, experts at OU Health completed the state's first liver transplant for a particularly challenging and oftentimes deadly form of a bile duct cancer known as cholangiocarcinoma. This achievement not only places OU Health among the few elite programs in the country that treat bile duct cancers with transplantation, but also brings immense relief to Oklahomans who no longer must leave the state to receive life-saving treatment.

Before the first transplant at OU Health, patients traveled to centers several hundred miles away for a transplant to address hilar cholangiocarcinoma. Hilar cholangiocarcinoma – bile duct cancer that occurs where the ducts exit the liver – is one of the most lethal cancers and among the hardest to treat. The overall five-year survival for those diagnosed with this disease is less than 10%. Historically, the only chance at a cure is to surgically remove part of the organ.

Only 20 to 30% of patients are eligible for a surgical option due to how aggressive and advanced the cancer can be at the time of diagnosis. For the few patients who are candidates for surgery, the complex operation requires removing up to 70% of the liver, resulting in a high risk of morbidity and mortality. The procedure is only performed at a few high-volume centers with expertise and resources for complex hepatobiliary surgery, which now includes OU Health.

Ajay Jain, MD

The patient at OU Health was first treated with a complex regimen of preoperative chemotherapy and radiation, said OU Health Stephenson Cancer Center surgical oncologist Dr. Ajay Jain M.D., FACS, core medical director for Stephenson Cancer Center and professor of surgery and chief of the Division of Surgical Oncology in the Department of Surgery at The University of Oklahoma College of Medicine. Dr. Jain also serves as Oklahoma State Chair for the American College of Surgeons Commission on Cancer.

However, Dr. Jain recognized that a liver transplant would offer the highest chance of success and thanks to OU Health's ability to perform a liver transplant for this complicated disease, the patient now has a higher chance of long-term survival.

The Most Challenging of All Cancers Cholangiocarcinoma is a type of cancer affecting the bile ducts carrying the digestive fluid bile from the liver to the gallbladder and small intestine. It typically occurs in individuals over the age of 50, though it can occur at any age.

Because of its aggressive nature, cholangiocarcinoma is often diagnosed when the cancer is advanced, making successful treatment difficult to achieve.

“Only 20 to 30% of patients with this cancer will be able to receive surgical treatment options because the disease is silent, and when it gets diagnosed, most patients will be at an advanced state where surgical resections or transplants are not possible,” said OU Health Transplant Institute surgeon Dr. Narendra Reddy Battula, MBBS, MRCS, M.D., FRCS, assistant professor in the Division of Transplant Surgery in the Department of Surgery at OU College of Medicine.

The transplant technique for bile duct cancers differs from liver transplant done for liver failure or liver cell-based cancer. When we do routine liver transplants, we disconnect the bile ducts. But when we treat bile duct cancer, we need to do an extensive removal of the bile duct, which joins the liver to the bowels near the pancreas. We must make sure no cancer has spread beyond the liver.”

In the late 1990s, Mayo Clinic began the first clinical trials to assess the use of liver transplantation as a treatment for hilar cholangiocarcinoma. Over several years and multiple clinical trials, data has shown that patients who undergo successful transplants have five-year survival rates of 65 to 68%, and 10-year survival rates reaching up to 60%. This marks a significant improvement compared to the usual 10% five-year survival rate associated with the diagnosis.

Despite the improved survival rates, only roughly 20 programs in the country offer transplantation for cholangiocarcinoma. This limitation stems from the demanding nature of the procedure which requires specialized, multidisciplinary expertise from various fields, including interventional radiology, advanced gastrointestinal, medical oncology, radiation oncology, hepatobiliary surgery, transplant surgery, and transplant medicine, to name a few.

OU Health Makes History in Oklahoma “OU Health now performs more than 50 traditional liver transplants a year, and because of the expertise at Stephenson Cancer Center and our outstanding transplant program at OU Health already doing some of the most complicated transplants in the country, we felt we could start doing liver transplants for cholangiocarcinoma,” said Dr. Jain. “This transplant was the first one of its kind done in the state.”

Narendra Battula, MD

Dr. Battula and his colleague, transplant surgeon Dr. Maheswaran Pitchaimuthu, MBBS, MRCS (Edin.), FRCS (Eng.), assistant professor in the Division of Transplant Surgery in the Department of Surgery at OU College of Medicine, worked alongside a team of medical oncologists, radiation oncologists and transplant hepatologists to implement diagnostic, chemotherapy and radiation protocols needed for this innovative treatment.

Other key medical professions included Stephenson Cancer Center oncologists Dr. Hassan Hatoum, M.D., Dr. Ryan Nipp, M.D., MPH, and Dr. Susanna Ulahannan, M.D., MMed, as well as radiation oncologists Dr. Andrea Johnston, M.D., and Dr. Christopher Bozarth, M.D.; advanced endoscopy specialist Dr. Amir Rumman, M.D., and transplant hepatologists Dr. Abdul M. Oseini, M.D., MSc and Dr. Sidra Ahsan, M.D. “All these patients were being referred to other centers out of state to be considered for transplant, and we had to question ourselves as to why we weren’t offering this,” Dr. Battula said. “We have an amazing cancer center and an amazing transplant center here. It’s a huge emotional burden for the patient and their families to be far away in an unfamiliar environment. We have all the components, and now we are the only center in the state who can offer this type of liver transplant.”

CITATION: First Liver Transplant for Aggressive Cancer Achieved at OU Health. (2024, November). https://www.ouhealth.com/blog/2024/june/firstevidence-based-liver-transplant-for-aggres/#~ce56ae54-eaa4-4ba0-9077-6aeccd154a2b

Center of Excellence for Rectal Cancer Accreditation Earned by OU Health Stephenson Cancer Center -Story provided by OU Health | OU Division of Marketing and Communications

OU Health Stephenson Cancer Center at the University of Oklahoma Health Sciences has earned a three-year accreditation from the National Accreditation Program for Rectal Cancer (NAPRC), making it the only accredited program in Oklahoma and one of only three other accredited programs within a 500-mile radius to receive the accreditation from the quality program of the American College of Surgeons.

NAPRC accreditation reinforces OU Health’s commitment to excellence in rectal cancer care. Treatment approaches will align with the latest evidence-based care and best practices. Patients treated at NAPRC- accredited centers can expect improved outcomes, including higher survival rates and better preservation of bodily function.

“The NAPRC accreditation is a monumental win for Oklahoma,” said OU Health surgical oncologist, Barish Edil, M.D. FACS, professor and Chair of the Department of Surgery at the OU College of Medicine at the University of Oklahoma Health Sciences.

“With this accreditation we can continue to provide world-class treatment for Oklahomans with rectal cancer, while furthering research, and care options. I am proud of what we are accomplishing as a patient-centered, multidisciplinary cancer team.”

Steven Carter, MD

To achieve NAPRC accreditation, a rectal cancer center must demonstrate compliance with the NAPRC standards addressing program management, clinical services, and quality improvement for patients. Centers are required to establish a multidisciplinary rectal cancer team that includes clinical representatives from surgery, pathology, radiology, radiation oncology, and medical oncology. Only the programs committed to providing the best care possible to patients with rectal cancer are granted accreditation by the NAPRC. Additionally, the team demonstrated an adherence to standards addressing clinical services set for the rectal cancer program. This accomplishment ensures that patients receive consistent and high-quality care, including essential clinical services such as Carcinoembryonic Antigen (CEA) testing, Magnetic Resonance Imaging (MRI), and Computerized Tomography (CT) imaging for accurate cancer staging. Importantly, patients can start their treatment within a defined timeframe, leading to better outcomes and improved well-being.

Kristina Booth, MD

“This is a major achievement for our organization,” said OU Health surgical oncologist, Ajay Jain, M.D. FACS, professor and Division Chief of Surgical Oncology at the OU College of Medicine at the University of Oklahoma Health Sciences. “This achievement is the culmination of more than five years of effort that started in July 2019. Members of the program put in tremendous time and effort to optimize quality, communication, and rapid care for rectal cancer patients as mandated by over 20 rigorous NAPRC standards. This even included photo documentation of all rectal cancer specimens in order to ensure adequate surgical technique was applied and the mesorectal excision was complete.”

The NAPRC accreditation is a recognition of Stephenson Cancer Center’s commitment to providing high-quality, patientcentric, and multidisciplinary approach to care. As the state’s only NCI-designated Cancer Center, the accreditation underscores the commitment of Stephenson Cancer Center as the largest and most comprehensive oncology practice in Oklahoma, highlighting the collaborative efforts of specialists from various fields under the one roof.

“Rectal cancer is uniquely challenging to treat due to its location,” said OU Health colon and rectal cancer surgeon, Steven N. Carter, M.D., FACS, FASCRS, Rectal Cancer Center Program Director. “Adherence to proper surgical techniques has shown a 75% decrease in local cancer recurrence. OU Health has policies and procedures to continually evaluate our performance and to ensure the best possible outcomes for patients with rectal cancer. It requires a team effort, and this designation with its standards ensures we are giving Oklahomans the care they deserve.”

In Oklahoma, colon and rectal cancers are 19% higher than the national average. The American Cancer Society reports that the number of people getting diagnosed with colon cancer has doubled since 1995, yet, more than one in three Oklahoma adults ages 50 and older are not getting tested as recommended. Screening for colon and rectal cancers should start at 45-years-old. Statistics show that 90% percent of all individuals diagnosed with colorectal cancer, at an early or local stage, are still alive five years later. OU Health surgeons offer patients the best chance to avoid stomas, cure stage 4 disease, and get back to what they enjoy most.

CITATION: Center of Excellence for Rectal Cancer Accreditation Earned by OU Health Stephenson Cancer Center (2024, February). https:// www.ouhealth.com/blog/2024/february/center-of-excellence-for-rectal-cancer-accredita/#~ce56ae54-eaa4-4ba0-9077-6aeccd154a2b

Academic Faculty

Administrative Staff Amanda Gillum Administrative Assistant

Surgeons Paulo Martins, MD Assistant Professor Maheswaran Pitchaimuthu, MD Assistant Professor

Hepatologist

Nephrologist

Jason Cheng, MD Assistant Professor

Ahmed Qudaih, MD Assistant Professor

Abdul Oseini, MD Assistant Professor

Muhammed Panezai, MD Assistant Professor

Harlan Wright, MD Assistant Professor

Elzbieta Rybicka, MD Assistant Professor

TRANSPLANT SURGERY

Narendra R. Battula, MD, FRCS Associate Professor Section Chief of Transplant Director OU Health Transplant Institute Transplant Surgeon OU College of Medicine | OU Health Department of Surgery

Message from Dr. Jain ~OU Health Joins an Elite Group of Cancer Transplant Programs - First Liver Bile Duct Cancer in Oklahoma~ Dear All: It is my honor and pleasure to announce a major milestone for the Transplant Division in the Department of Surgery, the multidisciplinary GI oncology programs at the Stephenson Cancer Center, and the citizens of Oklahoma. The transplant program recently completed the first ever liver transplant for cholangiocarcinoma in the state. This means our transplant oncology program has entered the ranks of a few elite programs in the country that treat bile duct cancers with transplantation.

Hilar cholangiocarcinoma (bile duct cancer that occurs where the ducts exit the liver) is one of the most lethal cancers, and amongst the hardest to treat. Overall 5 year survival for those diagnosed with this disease is less than 10%.

Historically, surgical resection offers the only chance of cure, but only 30% of patients are even eligible for surgery because the disease is usually too advanced at the time of diagnosis. For the few patients who are candidates for surgery, the complex operation requires removing 75% of the liver. It carries a high risk of morbidity and mortality. The procedure is only done at a few, high volume centers with expertise and resources for complex hepatobiliary surgery, including OU. Even in patients who undergo successful surgery to remove the cancer, 5 year survival is only around 30%. None of the patients I have operated on in the 17 years I have practiced have been long term survivors.

In the late 1990s, Mayo clinic began the first clinical trials to assess the use of liver transplantation as a treatment for hilar cholangiocarcinoma. Over several years and a series of clinical trials, resultant data show that patients who are successfully transplanted have five year survival rates of 65-68%, and 10 year survival rates of up to 60%. This was a miraculous advance. However, only 20 programs in the country offer transplantation for cholangiocarcinoma. The reason is that cholangiocarcinoma transplant requires specialized, highly-skilled, multidisciplinary expertise (interventional radiology, advanced GI, medical oncology, radiation oncology, hepatobiliary surgery, transplant surgery, and transplant medicine, to name a few).

Over the last few years, our transplant surgery program, comprised of our current Program Leader, Dr. Narendra Battula, and his colleague Dr. Maheswaran Pitchaimuthu, has become a fixture in the SCC GI multidisciplinary tumor board. They and the medical oncologists (Drs. Hatoum, Nipp, George, and Ulahannan), radiation oncologists (Drs. Johnson and Bozarth), and transplant hepatologists (Drs. Oseini and Ahsan) worked together to implement the perioperative diagnostic, chemotherapy, and radiation protocols needed for this cutting edge treatment. Before this first transplant at OU, these patients would need to leave the state of Oklahoma to centers several hundred miles away.

Our patient received a complex regimen of preoperative chemotherapy and radiation, followed by a liver transplant. Final pathology in the removed liver showed that the tumor showed near complete regression after the preoperative chemotherapy and radiation. Based on the data we have, the patient should have a favorable prognosis with a 60% chance of long term survival.

When I arrived here in 2019, the program was averaging only one liver transplant per year. Since Dr. Edil integrated the transplant surgery program into the Department of Surgery with new faculty and leadership in 2021, the volumes have increased tremendously. In 2023, Drs. Battula and Pitchaimuthu set the all-time annual record, completing 53 liver transplants. This expertise and volume allowed them to expand role of liver transplantation into cancer care.

Again, this was an amazing team effort that was self-initiated by a group of physicians and staff (from multiple Departments in the SCC and Hospital, including many others not named here), who were solely motivated to provide the best care for the people of Oklahoma.

Congratulations and Well Done!

Ajay

‘A Special Angel in Live’ - OU Health Transplant Institute Saves Lives -Story provided by OU Health | OU Division of Marketing and Communications

Time is of the essence for patients waiting for organ transplants. Organ donors are desperately needed as the average wait for a kidney transplant is four years.

“It takes 10 to 12 years to be on a list to get a kidney on the East and West Coasts,” said Pam Toho, RN, kidney and pancreas coordinator for pediatrics and adults at the OU Health Transplant Institute, located in Oklahoma City. “And in the Bible Belt here, our wait time is four to six years for them to get a kidney. So, all the people that can are flying into Oklahoma and the Bible Belt.

It’s everyone’s right to multi-list in many states to get a kidney, liver, or a pancreas quicker, Toho said. The OU Health Transplant Institute has a 275-mile radius of local organ offers that they receive first. If there is not a local organ match, then the search goes national.

“We want them to stay here at OU, but our whole mindset is to be an advocate for the patient,” Toho said.

One of her favorite things about being a nurse is calling someone to say, “Hey, we have a potential organ offer for you.

Today could be your day.”

There remain a few hurdles to overcome before they get to the final finish line for an organ that matches them.

“We have to see if they have to be dialyzed. When we take their blood, we make sure there is no infection in their bodies because if we’re going to transplant someone in the OR, we wipe their immune system out.”

It takes three months for the immune system to rebound, so there should be no open wounds or sores present on the patient. Harm could be done if infections are present.

An adult male recently flew in from California where he had been on a waitlist for five years. The operating room was set for him after the crossmatch was done. Blood was flown in during the middle of the night. The medical staff observe patients closely to ensure their immune system is healthy.

“It’s almost like a seesaw with doctors balancing their medications, looking at peaks and throughs to get a therapeutic level,” Toho explained. “That’s what we look for, so your body doesn’t attack the kidney and reject it.”

Organ recipients continue to be monitored for three to five years, getting them evaluated and keeping them healthy.

Once a transplant is completed, the patient is seen twice a week for the first three months; then once every two weeks for a couple of months, followed by once-a-month evaluations for a year or two.

“Then we refer them back to their nephrologist and see them once a year to keep tabs on the organ itself. We have a relationship to see if they need a kidney again,” she continued.

“Then we refer them back to their nephrologist and see them once a year to keep tabs on the organ itself. We have a relationship to see if they need a kidney again,” she continued.

The OU Health Transplant Institute averages 40-50 pediatric and adult kidney transplants a year, involving both living and deceased kidney donors. Each year, that includes 7-10 pediatric kidney transplants.

“That’s exciting. It’s been a while since we’ve had parents that were able to donate,” Toho said.

However, it looks like two pediatric donations will be processed. Toho said these donations will give children the best long-lasting kidneys the OU Health Transplant Institute can offer.

“A living donor related kidney is the very best kidney,” Toho said. “The length of time that it lasts — we’ve seen some people keep their kidneys as long as 30 years for a living donor related. For a normal lifespan of a transplanted kidney from a deceased donor, which is an amazing gift of life as well, the average is seven to 10 years. And they will likely need another kidney.”

Toho said it is her greatest privilege to work with a 38-person team to save lives. According to the United Network of Organ Sharing, the OU Health Transplant Institute has a 100 percent, 3-year-patient survival rate for living donor and deceased donor transplants at Oklahoma Children’s Hospital OU Health, Toho said and the publicly reported SRTR website.

It’s hard for Toho to explain the joy that being part of an organ transplant team has brought to her life.

“I have a relationship with all of these kids. You just form relationships with them forever,” she said. “You feel like you are a special angel in their life. They just have a bond with you.”

CITATION: A Special Angel in Life - OU Health Transplant Institute Saves Lives (2024, January). https://oknursingtimes.com/02-12-24/a-special-angel-inlife-ou-health-transplant-institute-saves-lives/

Academic Faculty Ajay Jain, MD Program Site Director, General Surgery Residency Kristina Booth, MD Associate Program Director, General Surgery Residency Frank Wood, MD Assistant Program Director, General Surgery Residency

Coordinators Berta Orta Lead Residency Program Coordinator General Surgery Residency Kara McCroskey Education Program Coordinator General Surgery Residency

Suhair Maqusi, MD Plastic & Reconstructive Surgery Fellowship Program Director Alexander Raines, MD Co-Director of Surgical Clerkship Residency Program Site Director - OU Edmond Jeremy Johnson, MD Co-Director, Third Year Clerkship Alessandra Landmann, MD Fourth Year Surgery Clerkship Director Surgical Critical Care Fellowship Program Director

Raven Nelson Lead Education Program Coordinator Pediatric Surgery & Surgical Critical Care Fellowships

Jason Lees, MD Associate Dean of Graduate Medical Education-Designated Institutional Official

Magali Ochoa Plastic Surgery Faculty Assistant Senior Education Program Coordinator

Morgan Bonds, MD Assistant Dean of Admissions College of Medicine

EDUCATION

Jason S. Lees, MD, FACS Robert D. Gordon, Jr. Professor of Surgery Section Chief Acute Care Surgery & Burns Associate Dean of Graduate Medical Education-Designated Institutional Official Vice Chair of Education OU College of Medicine | OU Health Department of Surgery

Catherine Hunter, MD Pediatric Surgery Fellowship Program Director

Lees Named Associate Dean of Graduate Medical Education -Story by OU Division of Marketing and Communications

In May 2024, the College of Medicine announced the appointment Jason S. Lees, M.D. as the new associate dean of Graduate Medical Education (GME) and the college’s Designated Institutional Official (DIO). Lees brings a wealth of experience and a commitment to excellence in medical education, clinical practice, and research to this role.

“I am trilled to welcome Dr. Jason Lees as the Associate Dean of Graduate Medical Education,” said Ian F. Dunn, M.D., FACS, FAANS, executive dean of the college. “His unwavering dedication to education, research, clinical excellence, and leadership made him the ideal choice to lead our graduate medical education programs into the future.”

A native of Edmond, Lees is deeply rooted in the state of Oklahoma and has an impressive academic background. he graduated Magna Cum Laude with a Bachelor of Science in Zoology from the University of Oklahoma before earning his Doctor of Medicine degree from the OU College of Medicine. Following his medical education, Lees completed his residency in General Surgery at OU, where he was honored as the Lloyd Rader Outstanding Graduating Resident.

Lees furthered his training with a fellowship in trauma and surgical critical care at Jackson memorial Hospital and the University of Miami. He then pursued a surgical education research fellowship through the Association of Surgical Education.

Throughout his career, Lees has demonstrated a commitment to advancing medical education and clinical care. He has served as the program director of the General Surgery Residency program since 2012, overseeing its significant growth and achieving outstanding board passage rates. According to Dunn, Lees’ leadership has been instrumental in the success of the program, which has garnered national recognition.

“I am honored to have been named the associate dean of Graduate Medical Education at the OU College of Medicine, “ said Lees. “I am deeply committed to fostering a supportive learning environment where residents and fellows can thrive, and I look forward to working collaboratively with colleagues to uphold the highest standards of clinical medical education.”

Lees’ appointment comes at a pivotal time for medical education, and his expertise will be invaluable as the College of Medicine continues to innovate and adapt to the evolving needs of healthcare professionals and patients.

“I am confident that in his new role, Dr. Lees will continue to champion excellence in graduate medical education, mentorship, and professional development for our residents and fellows. He will work closely with leaders across the College of Medicine to ensure the highest standard of training, equipping the next generation of physicians for unparalleled success, “ said Dunn.

CITATION: Lees Names Associate Dean of Graduate Medical Education (2024, May). OU Medicine A Bold Step Forward Winter 2024-2025 Newsletter, pg 8

OU College of Medicine Appoints New Assistant Deans to Lead Graduate Medical Education Program -Story by OU Division of Marketing and Communications

The University of Oklahoma College of Medicine has appointed Kristina Booth, Christina Henson and Mubeen Shakir as assistant deans in its Graduate Medical Education program. The expansion of the leadership team will support advancements in program management, learner assessment and wellness initiatives for residents and fellows.

With new Accreditation Council for Graduate Medical Education (ACGME) requirements on the horizon, the OU College of Medicine is strengthening the connection between the sponsoring institution and its core clinical sites, says Jason Lees, MD, FACS, associate dean of graduate medical education and a general and trauma surgeon at OU Health.

“The role is becoming more expansive, requiring a broader skill set and offering significant opportunities for program development. We are focused on helping directors and coordinators learn best practices from each other and on setting high standards in program quality,” Lees said.

The new assistant deans will help lead the Graduate Medical Education program, supporting the OU College of Medicine.

Kristina Booth, MD, FACS, will serve as assistant dean for program development, learner assessment and wellness. An associate professor in the OU Department of Surgery, she has been associate program director for the general surgery residency for six years, where she launched a well-being curriculum that includes policies for lactating residents, resident competitions and social activities. She has led faculty development efforts, introducing innovative evaluation techniques and is nationally recognized for advancing competency-based education through the Society for Improving Medical Professional Learning and the American Board of Surgery’s Entrustable Professional Activities initiative. She has also contributed to national education projects, presented nationally and mentored associate program directors. Within the OU College of Medicine, she serves on the Academy of Teaching Scholars Executive Committee, is a Student Learning Community Mentor and received the Dewayne Andrews Excellence in GME Teaching award. A native Oklahoman, she earned a bachelor’s degree at Oklahoma Baptist University, a medical degree and surgical training at OU College of Medicine and a fellowship in colorectal surgery at Texas Health Presbyterian/UT Southwestern. In the new role, she will promote GME best practices, support program development and enhance resident wellness initiatives.

CITATION: OU College of Medicine Appoints New Assistant Deans to Lead Graduate Medical Education Program. (2024, November). https://www.ouhsc/ news/details/ou-college-of-medicine-appoints-new-assistant-deans-to-lead-graduate-medical-education-program.

Academy of Teaching Scholars Dr. Kristina Booth - Co-Chair of Recognition & Awards Committee Dr. Frank Wood - Academy of Teaching Scholars Dewayne Andrews, MD Excellence in Teaching Award Recipient

Academic Faculty William Berry, Ph.D. Assistant Professor Tabitha Garwe, Ph.D. Associate Professor Min Li, Ph.D. Professor Kenneth Stewart, Ph.D. Assistant Professor

https://redcap.ouhsc.edu/redcap/surveys/?s=8DCMJAC488 represents a one-stop shop for contacting the OUCARES team for assistance with biostatistics, IRB submissions, Study Coordinator/Research Nurse, and research tissue processing/staining.

RESEARCH

Lacey McNally, PhD Tenured Professor of Surgery Vice Chair of Research Advancement OU College of Medicine | OU Health Department of Surgery

OU Health Sciences Tests Revolutionary Imaging Technique for Pancreatic Cancer -Story provided by OU Health | OU Division of Marketing and Communications

Researchers at OU Health Stephenson Cancer Center at the University of Oklahoma Health Sciences have embarked on a revolutionary new research study that could improve the detection of a deadly disease — pancreatic cancer — and give patients a chance to live longer, healthier lives.

The research focuses on an innovative combination of imaging techniques: a newly created contrast agent that recognizes pancreatic cancer cells, paired with Multispectral Optoacoustic Tomography, or MSOT. Together, the approach can detect pancreatic cancer cells the width of an eyelash — approximately 10 times more magnitude than what is currently possible. The research is led by Lacey McNally, Ph.D., and Ajay Jain, M.D., who are professors of surgery at the OU College of Medicine.

They received a $3 million grant from the National Cancer Institute of the National Institutes of Health for this project, which is believed to be among the first of its kind in the world.

“Pancreatic cancer is one of the hardest cancers to cure because it is difficult to detect cancer cells at the microscopic level,” Jain said. “Because there are usually no early symptoms of pancreatic cancer, it is typically not diagnosed until after it has spread, and outcomes are very poor — about a 9% overall chance of survival. Surgery and chemotherapy offer the patients the best chance, but for surgery to work, we have to remove all the cancer, and that is difficult to do.”

The new imaging approach aims to improve the detection of pancreatic cancer cells at the microscopic level, or about 200 microns, about as thin as an eyelash. Current imaging options like the CT scan only detect cancer when it grows larger, about a centimeter in size.

The promise of the new imaging approach is in the combined strength of its two elements. In the laboratory, McNally devised a contrast agent unique to pancreatic cancer cells. When the agent is delivered via an IV, it can differentiate pancreatic cancer cells from other cells because the environment of pancreatic cancer is acidic.

When the contrast agent encounters that acidity, its dye essentially “turns on.”

The other component, the MSOT device, works in concert with the contrast agent.

The MSOT delivers infrared light into the body, which stimulates the dye of the contrast agent. That stimulation creates sound waves, which the MSOT device picks up and converts into colors. The result is an image so detailed that it captures cancer cells that otherwise would evade detection.

“This is a hybrid approach that accomplishes what a CT cannot,” McNally said. “Pancreatic cancer often creates tentacles that spread out beyond the primary tumor. Currently, there is no way for the surgeon to know where they are.

But if the surgery team can use this MSOT approach in the operating room, it can tell them in real time where the cancer has metastasized so they can remove it.”

That capability would be a game-changer for pancreatic cancer surgeons. Pancreatic cancer disproportionately affects people 60 and older, who face greater risks from a major operation than younger patients do and usually cannot withstand a second surgery.

“The first questions patients ask me are, ‘Will the surgery be worth it? What are the chances that you’ll get it all?’ This approach, at a very microscopic level, appears able to inform us whether we are getting all the cancer,” Jain said.

The new imaging technique could also help surgeons plan the surgical approach they want to take. If the MSOT device reveals, for example, that cancer has invaded the two critical blood vessels that hug the head of the pancreas, surgeons would conduct the procedure differently than if they didn’t know. If chemotherapy is given before surgery, the imaging could tell whether cancerous cells on the blood vessels are dead or if microscopic cancer is still present.

Ultimately, the new imaging approach could be used as a screening tool in patients who face a high risk of pancreatic cancer, such as those who have a family history or have a genetic predisposition. “Early detection of pancreatic cancer offers the best chance of a cure,” Jain said. “If we could detect the cancer at an early, microscopic stage, it could be curable.”

The grant's funding will allow McNally and Jain to continue testing the imaging technique. McNally is an international leader for her research expertise in using the MSOT device with contrast agents she has developed for various cancers.

She is testing the imaging approach in several other clinical trials at OU Health Sciences, including a recently completed study in breast cancer. While MSOT technology is not new, it is novel in medicine, and funding agencies like the NIH are increasingly supporting studies in the field. McNally and Jain’s grant scored in the first percentile out of approximately 55,000 grants submitted last year to the National Cancer Institute, which points to the strength of the research.

“This type of research collaboration between a translational scientist and a surgeon is extremely unusual,” McNally said.

“We have the opportunity to improve a surgical technique. The scientific and medical communities have made great strides in treating some types of cancer, but pancreatic cancer patients have the poorest survival. The outcome of this research could fundamentally change people’s lives.”

The University of Oklahoma and Georgia State University jointly own pending patent applications on contrast agents and using the MSOT device with contrast agents.

Research reported in this press release is supported by the National Cancer Institute, a component of the National Institutes of Health, under award number 1R01CA281098-01A1.

CITATION: OU Health Sciences Tests Revolutionary Imaging Technique for Pancreatic Cancer (2024, January).https://inside.ouhsc.edu/news/article/ouhealth-sciences-tests-revolutionary-imaging-technique-for-pancreatic-cancer

Li serves as President of American Pancreatic Association -Story provided by OU Health | OU Division of Marketing and Communications

Min Li, Ph.D., a George Lynn Cross Professor of Medicine, Surgery and Cell Biology at the University of Oklahoma College of Medicine and Associate Director for Global Oncology at OU Health Stephenson Cancer Center, will receive the 2024 Palade Prize from the International Association of Pancreatology.

The Palade Prize, the IAP’s most distinguished award for research excellence, recognizes Li’s contributions to the field of pancreatology, which is dedicated to discovering new methods of identifying, diagnosing and treating diseases of the pancreas such as pancreatic cancer. The award is named after George E. Palade, who won the Nobel Prize in 1974 for his pioneering work involving a specialized pancreatic cell type. Li will receive the prize during the IAP annual meeting Dec. 9-12, and he will give a lecture on cancer cachexia and metabolic reprogramming.

Li has been continuously funded by the National Cancer Institute, a component of the National Institutes of Health, for the past 15 years, including three active R01 grants. His contributions to science focus on three areas: Development of a combination therapy for pancreatic cancer using a novel surgical mouse model. As part of this work, his laboratory was the first to discover the role of a zinc transporter called ZIP4 in both pancreatic cancer and cachexia, a muscle-wasting condition that often occurs in tandem with pancreatic cancer.

Metabolic reprogramming and muscle wasting in pancreatic cancer. In this area, Li searches for a method of controlling the rapid weight loss of cachexia, which has no treatment. He is currently focused on the role of several enzymes and growth factors in the progression of cachexia.

Immunotherapy of pancreatic cancer. Because most immunotherapy drugs alone are not effective against pancreatic cancer, Li’s team developed a phototherapy/immunotherapy combination treatment that has been highly effective in mice with metastatic pancreatic cancer.

Li has published 216 articles in high-impact peer-reviewed journals and has given presentations on his research around the world. He has also mentored more than 30 graduate students and postdoctoral fellows, who have gone on to research careers in academia and industry, as well as junior faculty members who are beginning their careers.

Li is immediate past president of the American Pancreatic Association and is a standing member of the NIH Developmental Therapeutics study section and an ad hoc member of many other NIH study sections. He is editor-inchief for the journal Cancer Letters and is an editorial board member for several other prestigious journals, including Clinical Cancer Research and BMC Medicine. He is also a member of the American Association for Cancer Research and the Association for Academic Surgeons.

He holds several other titles at OU Health Sciences, including Assistant Dean for International Research Collaboration in the OU College of Medicine; Vice Chairman for Research in the Department of Medicine and Department of Surgery, OU College of Medicine; and co-leader of the Cancer Biology Program at OU Health Stephenson Cancer Center. He also holds the Virginia Kerley Cade Endowed Chair in Cancer Treatment.

CITATION: Li serves as President of American Pancreatic Association (2024, December). OU Medicine A Bold Step Forward Winter 2024-2025 Newsletter, pg 47

Researchers Discover Cell ‘Crosstalk’ That Triggers Cancer Cachexia -Story provided by OU Health | OU Division of Marketing and Communications

New research from the University of Oklahoma reveals a previously unknown chain of events sparking the development of cancer cachexia, a debilitating muscle-wasting condition that almost always occurs in people diagnosed with pancreatic cancer.

The research, led by Min Li, Ph.D., a professor in the OU College of Medicine, is published in the journal Cancer Cell. The study is a collaboration with researchers from Johns Hopkins School of Medicine, the University of Texas Health Science Center and Yale School of Medicine.

In the study, researchers discovered that “crosstalk” between pancreatic cancer cells and macrophages (a type of immune cell) is the first step toward the onset of cachexia. Macrophages usually protect the body from infection, but in this case, the pancreatic cancer cells recruit them to do harm. Their conversation in turn prompts increased secretion of TWEAK (TNF-like weak inducer of apoptosis), a protein known to play a role in cachexia by binding to receptors on the surface of muscle cells and causing inflammation. That sequence triggers the development of cachexia.

“Cancer cachexia is an understudied disease, and there are no good treatments, nor does nutritional support help with the symptoms,” Li said. “People lose their appetite and lose weight quickly, and because of that, they are weak and much less able to tolerate aggressive treatment for pancreatic cancer. The significance of this study is that it provides evidence of an underlying mechanism of cachexia. It is not the cancer cells alone or macrophages alone that start the process of cachexia, but the fact that they are talking to each other.”

Cancer cachexia isn’t a given with every cancer — it rarely occurs with breast cancer or brain cancer, for example — but it is most prevalent in pancreatic cancer, Li said. The study’s findings are important because by better understanding how cachexia begins, researchers can potentially develop a way to stop the cascade of events. “It gives us a therapeutic window to intervene and potentially stop or reduce cachexia, thereby giving patients a better chance of fighting pancreatic cancer,” Li said. “Our next step is to try to develop a drug, possibly one that blocks the crosstalk between the cancer cells and the macrophages.

“This is a paradigm-shifting research publication because it represents a new way of understanding how cancer cachexia begins,” he added. “The combination of pancreatic cancer and cancer cachexia significantly diminishes a person’s quality of life. If we can determine a way to reduce the burden of cachexia, people may have a better prognosis in their fight against pancreatic cancer, which now has a five-year survival rate of only 13% and is the third-leading cause of cancer-associated deaths in the United States.”

Pancreatic cancer is notoriously difficult to find in its early stages; over 80% of patients with the disease are diagnosed when the cancer is advanced and treatment options are limited. In addition to providing a potential target for treatment, Li’s research may contribute to the ongoing search for a means of diagnosing pancreatic cancer earlier.

Previous clinical studies have suggested that six to nine months before a diagnosis of pancreatic cancer, people begin losing fat then muscle.

“If a person loses more than 5% of their body weight in a six-month period for no reason, it could be a cause for concern,” he said. “Perhaps at some point, changes in a person’s body composition could help clinicians to diagnose cancer at an earlier stage before it has metastasized.”

CITATION: Researchers Discover Cell ‘Crosstalk” That Triggers Cancer Cachexia (2024, April). https://www.ouhsc.edu/news/details/researchers-discovercell-crosstalk-that-triggers-cancer-cachexia

Awards/Honors Ajay Jain, MD Association of Academy Surgery Basic Science Translational Research Award Oklahoma University 405 Top Doctors 2024 Promotion and Tenure Committee of the College of Medicine Member The G. Rainey Williams Research Professorship

Narendra Battula, MD Section Chief of Transplant Surgery

Jeremy Johnson, MD 2023-2024 Outstanding Teacher Award OUHSC Oklahoma University 405 Top Doctors 2024

Morgan Bonds, MD Oklahoma University 405 Top Doctors 2024 Kristina Booth, MD Oklahoma University 405 Top Doctors 2024 2024 Castle Connolly Top Doctor Harold Burkhart, MD Alpha Omega Alpha Honor Society Faculty Member 2024 Castle Connolly Top Doctor Dean's Award for Distinguished Medical Service, OUHSC Oklahoma University 405 Top Docs 2024 Named Senior Medical Directors for Children’s Services Chair Ad Hoc Tenure Review Committee Steven Carter, MD Russell Postier Award for Excellence in Resident Teaching, OUHSC Oklahoma University 405 Top Docs 2024 Juan Carlos Claros-Sorto, MD Oklahoma University 405 Top Docs 2024 Alisa Cross, MD Inaugural Member of OU College of Medicine Academy of Teaching Scholars Oklahoma University 405 Top Docs 2024 Named Senior Medical Director for ER/Trauma Faculty Board Member

Alessandra Landmann, MD Oklahoma University 405 Top Doctors 2024 Jason Lees, MD Oklahoma University 405 Top Doctors 2024 OKC Thunder Healthcare Champion of the Game Section Chief of Acute Critical Surgery & Burns Min Li, PhD OUHSC Provost Senior Research Award Virginia Kerley Cade Endowed Chair in Cancer Treatment Suhair Maqusi, MD Oklahoma University 405 Top Doctors 2024 Lacey McNally, PhD Association for Academic Surgery’s Basic Science/ Translational Research Award OUHSC Fernando Mier-Giraud, MD SAGES Recognition of Excellence-Community Practice Committee 2023-2024 Outstanding Teacher Award OUHSC 2024 Castle Connolly Top Doctor Mark Mims, MD Oklahoma University 405 Top Doctors 2024

William Dooley, MD America’s Top Doctors in Cancer Oklahoma University 405 Top Docs 2024

Chance Nichols, MD Aesculapian Award Clinical Sciences Faculty Nominee OUHSC

Barish Edil MD 2024 Castle Connolly Top Doctor Oklahoma University 405 Top Doctors 2024

Celia Quang, MD Frank A. Clingan Surgery Award, OUHSC

Christian El Amm, MD 2024 Castle Connolly Top Doctor Oklahoma University 405 Top Doctors 2024 Joshua Gierman, MD Oklahoma University 405 Top Doctors 2024 Student Promotions Committee Member The Harris Foundation Professorship Catherine Hunter, MD Oklahoma University 405 Top Doctors 2024 OUHSC Department of Pediatrics Mentorship Award Rosalind Franklin Society Special Award in Science Top 50 Women Leaders of Oklahoma for 2024 by Women We Admire Magazine Presidential Professorship Awardee

Alexander Raines, MD Oklahoma University 405 Top Doctors 2024 2024 Castle Connolly Top Doc Matthew Reinersman, MD Oklahoma University 405 Top Doctors 2024 Emily Switzer, MD Oklahoma University 405 Top Doctors 2024 Physician OU Health Way Champion Award Named Senior Medical Director of Critical Care Frank Wood, MD Russell G. Postier Award for Excellence in Resident Education Dewayne Andrews, MD Award for Excellence in Teaching Graduate Medical Education Oklahoma University 405 Top Doctors 2024

Awards | Research | Grants | Publications | Presentations

Guilherme Barreiro, MD ASPS Top Poster Award American Society of Plastic Surgery Outstanding Teacher Award OUHSC ASRM 2024 "Top 24 in 2024" Poster - Sensate Pedicled Anterolateral Thigh (ALT) Flap for Reconstruction of Pelvi- Perineal and Knee Region Defects

Grants/Research Morgan Bonds, MD Pancreas Cancer Specific Pancreas Cancer Probe for Image Probe for Image Guided Resection: NCI: Federal: Principle Investigator - $375,000 Current

Narendra Battula, MD Grant ASTS CareDx Faculty Research Grant American Society of Transplant Surgeons: Federal: Principal Investigator - 100% - $100,000 Current Grant Research Career Development Award Innovative Techniques for Organ Preservation, Repair and Reconditioning Department of Surgery, College of Medicine, University of Florida: State: Principal Investigator - 100% - $25,000 Closed Intramural Research Research Career Development Award University of Florida, Department of Surgery: State: Yes: Principal Investigator - 100% - $2,5000 Closed

Juan Claros-Sorto, MD Acquisition of Invasive phenotype in Biopsied Breast Tumor Inflammation and Biopsy-Site-Marker in Breast Cancer (MOSAIC): Co-Investigator- Awarded Development of an apoptosis biosensor for monitoring of breast cancer: NIH: Federal - Co-InvestigatorAwarded

William Berry, PhD ROCK, tight junctions and prematurity in the pathogenesis of necrotizing enterocolitis and neonatal sepsis: NIH/NDDK: Federal: 5% - $1,600,000 Current PDGFRB signaling in progressive skin disease: NIH/ NIAMS: Federal: 10% - $1,023,842 Current Mechanisms driving the formation of post-operative peritoneal adhesions: NIH/NIGMS: Federal - Other Investigator - 55% - $1,250, 000 Current US Patent 11,655,307 Anti-Doublecortin-Like Kinase 1 Antibodies and Methods of Use JP Patent 7366755 Anti-Doublecortin-Like Kinase 1 Antibodies and Methods of Use HK Patent 62020017684.5 Anti-Doublecortin-Like Kinase 1 Antibodies and Methods of Use CN Patent CN111010867 Anti-Doublecortin-Like Kinase 1 Antibodies and Methods of Use Scott Blair, DO Serum identification and phenotype assessment of traumatic brain injury and associated concussion disorders ECMO Success After and Electrifying NearDrowing; OU Cares: $6,500 Awarded ECMO success after an electrifying Near Drowning: Principle Investigator - under review Traumatic Brain Injury: Mortality and Functional Outcomes/Principle Investigator Biomarkers in Acute Respiratory Distress Syndrome: Does ECMO alter Rage and Ang-2? Principle Investigator $5,000 Awarded

Harold Burkhart, MD Tobacco Treatment Partnership: Co-Investigator $44,000 Awarded A Prospective Study of Patients with Hypoplastic Left Heart Syndrome Following StageII Surgical Paliation: Mayo Clinic: Principle Investigator - Awarded Phase 1 Safety Study of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Stage II Palliation of Hypoplastic Left Heart Syndrome: Mayo Clinic: Principle Investigator-Awarded “Risk stratification and predictive modeling enabled personalized management of tricuspid regurgitation in hypoplastic left heart syndrome”: OCAST: Principle Investigator: $134,880 Awarded

Alisa Cross, MD Transfusion and Prothrombin Complex Concentrate Study: Site Principle Investigator- Awarded Daily versus BID Dosing for Lovenox in Surgical Patients: OU Cares: Principle Investigator - $2,000 Awarded Resident Confidence and Operative Performance: Translating Procedural Workshops into the ‘Real Life’ Operating Room: Principle Investigator- $3,500 Awarded William Dooley, MD A Safety and Efficacy Study of Intra-Operative Radiation Therapy (lORT) Using the Xoft Axxent ebx System at the time of Breast Conservation Komen Flax Seed Lignin as a Prevention Strategy for premenopausal women at high risk for development of breast cancer: $139,000- Awarded Site Initiation of Novilase ILT Breast Cancer Study Protocol BR-002: $30,550- Awarded A Randomized Pivotal Trial to assess the Safety and Efficacy of Preoperative Focus Microwave Plus Preoperative Chemotherapy vs Preoperative Chemotherapy alone for Cytoreduction of Large Breast cancer in female pathis with intact breast.: $85,000.

Awarded Komen Flax Seed Lignin as a Prevention Strategy for postmenopausal women at high risk for development of breast cancer. $295,000 Awarded.

ASBrS Nipple sparing Mastectomy registry: Awarded Kansas-Breast Cancer Prevention by Letrozole in High Risk Women: NCI RO1 CA122577-01. Awarded Excel Prevention Study. A Phase 3 randomized study of Exemestance vs Placebo in post menopausal women at increased risk of developing breast cancer: NCIC CTG Trial Map 3. Awarded

Awards | Research | Grants | Publications | Presentations

Barreiro Guilherme, MD Development and study of alternative vascular supply for different flap configurations: Principal Investigator (non-funded) Development of a new stitch technique Development of new needle configurations: Principal Investigator (nonfunded) Development of surgical techniques and reconstructive alternatives with the aid of the robot: Principal Investigator (non-funded) New arterial mechanical coupler: Principal Investigator (non-funded) Study of alternative painless donor site options for skin grafts: Principal Investigator (non-funded) Study the effects of different nipple areolar pedicle for longer lasting results in breast reduction surgeries: Principal Investigator (non-funded) The challenge to overcome the rippling and the silicon footprint: Principle Investigator (non-funded)

Grants/Research William Dooley, MD (cont’d) A Randomized Phase III comparing 16 to 18 weeks of Neoadjuvant Exemestance (25mg daily) Letrozole (2.5mg) or Anastrozole (1mh in post-menopausal Women with Clinical Stage II and Stage III Estrogen Receptor Positive Breast Cancer. Z1031: Awarded Prediction of response to Neoadjuvent chemotherapy in women with operable breast cancer (PT304). $42,000.

Awarded

Christian El Amm, MD Neurodevelopmental outcomes of Craniosynostosis Surgery: Principle Investigator. Awarded Joshua Gierman, MD TREO Abdominal Stent-Graft System: Principal Investigator: Awarded Extremity Vascular Trauma with Soft Tissue Loss (non funded) Management of Extracranial Cerebrovascular Injury (non funded) Endovascular Aortic Aneurysm Repair at the Oklahoma City VA: A 10 Year Experience (non funded) Catherine Hunter, MD Redox regulation of cellular pathologies in necrotizing enterocolitis: Federal- Principal Investigator Awarded ROCK, Tight junctions and prematurity in the pathogenesis of necrotizing enterocolitis and neonatal sepsis: Federal- Principal Investigator - RO1 $3,400,000 Awarded Role of Creatine Metabolism in Necrotizing Enterocolitis: Federal- Co-Investigator $398,750 Awarded Ajay Jain, MD Randomized Phase 0 Pilot Study of High Dose Omeprazole in Patients with Pancreatic Cancer Planning to Undergo Surgical Therapy for Evaluating Changes of Biomarkers: Principal Investigator Awarded Identification of microRNAs in Cachexia in African Americans with Pancreatic Carcinoma: Principal Investigator Awarded Investigating whether high dose omeprazole can make pancreas cancers susceptible to cell death through alteration of tumor pH and suppression of autophagy: Co-Investigator Awarded Multicenter study investigating how pathologic complete response to chemotherapy correlates with outcomes in pancreas cancer patients: Co-Investigator Awarded Assessing how nutritional optimization and preconditioning can improve outcomes in patients undergoing a pancreaticduodenectomy: Awarded Assessment of frailty in hepatobiliary patients (non funded) Development of Contrast Agents to Facilitate ImageGuided Surgery: NCI - Principal Investigator: R01 100%pending Translational Research Award: Foundation- Supporting Investigator - $35,000 Awarded

Jason Lees, MD Splitting Hairs- How to Differentiate Sternotomy Performance Among Surgical Residents Using a Novel Training Program: Principal Investigator $1,146 awarded Mechanisms Driving the Formation of Post-Operative Peritoneal Adhesions:Foundation $250,000 Awarded The Roll of PDGF Signaling Mechanotransduction Nexus In the Development of Peritoneal Adhesions: State: $45,000 Awarded GRIT and its association with medical student specialty choice: (non-funded) SIMPL analysis for complexity of case entry (nonfunded) Office of Technology Development Growth Fund (nonfunded) US Patent 11,744,565 Surgical Evaluation Apparatus and Method Megan Lerner, HT (ASCP) Histology Services for Necrotizing Enterocolitis; Supporting Investigator Histology Services for Neurosurgery/OU Engineering TBI: Supporting Investgator Histology Services for Pancreatic Cancer: Supporting Investigator Histology Services for Wound Healing: Supporting Investigator Min Li, PhD Lysine methylation promotes NFAT5 activation and predicts the efficacy of temozolomide upon EGFR activation: Pending Genistein suppresses gallbladder cancer tumorigenesis and progression via downregulating ERBB2 mediated PTK6/AKT/MCM pathway: pending Development of contrast agents to facilitate imageguided surgery: Federal-NIH RO1 $1,250,000 Awarded Molecular Mechanism of Pancreatic Cancer Oncogenesis (12th percentile, pending council review): Principal Investigator - $1,250,000 Awarded Pancreatic cancer training program: Federal - Principal Investigator $1,319,129 Prognostic markers for pancreatic cancer metastasis and response to therapy (20th percentile on initial submission, revised, pending for review) Pancreatic cancer cachexia: Federal- NIH/NCI Principal Investigator $7,500,000 Awarded

Awards | Research | Grants | Publications | Presentations

Barish Edil, MD Novel Imaging Techniques in the Diagnosis and Treatment of Pancreatic Cancer. Principle Investigator. $30,000. Awarded

Jeremy Johnson, MD Effects of an Exclusive Human Milk Diet (EHMD) on Enteral Feeding Outcomes of Neonates with Congenital Gastrointestinal Disorders (GCD): Supporting Investigator Awarded Blunt Cerebrovascular Injury in Pediatric Trauma Patients: Co-Investigator Awarded The Association of Essential Fatty Acid Status with Surgical Wound Complications: Co-Investigator Awarded Trauma and Mild TBI in Pediatric Population: A Pilot Longitudinal Descriptive Study Assessing PostConcussive Symptoms, Functional and Quality of Life Outcomes: Co-Investigator Awarded Myofibroblast function in infant peritoneal adhesions: PHF-Supporting Investigator Awarded

Grants/Research Min Li, PhD (cont’d) Potentiating a systemic antitumor response by interstitial localized ablative immunotherapy to synergize with immune checkpoint therapy for metastatic pancreatic tumors; Federal-NIH 1 RO1 $1,991,744 Awarded Role of Zinc Dependent EMT-Transcription Factors (EMTTF) in Pancreatic Cancer Metastasis: Federal-NIH 1 RO1 $1,250,000 Awarded

Fernando Mier-Giraud, MD Effect of Psychotropic Medications on Bariatric Surgery Outcomes: Principal Investigator Awarded Facilitators and Barriers Related to Starting a Career in Academic Surgery: Principal Investigator Awarded 1-Year Bariactric Surgery Outcomes in Native Americans Compared to Caucasians: Principal Investigator Awarded Enterra® Therapy Gastric Stimulation System HDE Number: H990014: Principal Investigator Awarded Alexander Raines, MD Heart Rate Variability as a Measure of Stress and EEGdirected Meditative Practices in Medical Students Participating in a Stress Management Training Program Academy of Teacher Scholars The University of Oklahoma: Principal Investigator 100% $5000 Awarded Matthew J. Reinersman, MD CHIO3 Trial: Chemotherapy Combined with lmmune Checkpoint lnhibitor for Operable Stage lllA/B NonSmall Cell Lung Cancer, SCC Oklahoma Tribal Rural, Urban Cancer Screening: Principal Investigator $59,010 Awarded Chemotherapy Combined with lmmune Checkpoint lnhibitor for Operable Stage lllA/B Non-Small Cell Lung Cancer: Principal Investigator Awarded TSET for Mobile Lung Cancer Screening: CoInvestigator Awarded

Awards | Research | Grants | Publications | Presentations

Lacey McNally, PhD Optoacoustic Detection of Inflammation Using MSOT Device: Principal Investigator: Awarded Pilot trial to identify microRNAs in cachexia patients with pancreatic carcinoma: Co-Principal Investigator: Awarded A Randomized Phase 0 Study of High Dose Omeprazole in Patients with Pancreatic Cancer Planning to Undergo Surgical Therapy for Evaluating Changes of Biomarkers: Co-Principal Investigator: Awarded A hybrid drug delivery system for targeting the three hallmarks of pancreatic cancer: National Cancer Institute (NCI): Supporting Investigator: R01 CA292822-01 Assessment of FLT-PET and MSOT for GVHD: National Cancer Institute (NCI): Principal Investigator: R01CA289758-01:Pending Development of a hybrid intraoperative imaging probe: National Cancer Institute (NCI): Principal Investigator: R01 CA285427-A1: Pending Development of small molecule dyes (COP) for detection of pancreatic cancer using MSOT: National Cancer Institute (NCI): Principal Investigator: 2R01CA205941-07A1: Pending Development of contrast agents to facilitate imageguided surgery: National Institute of Health (NIH), National Cancel Institute (NCI), Oklahoma University Health Sciences Center The University of Oklahoma: Principal Investigator: R01CA281098-01A1: 20% $2928601: Awarded Development of an apoptosis biosensor for monitoring of breast cancer: National Institutes of Health (NIH) & National Institute of Biomedical Imaging and Bioengineering (NIBIB): Principal Investigator: R01EB034731-01: 20% $2075527: Awarded Bioengineering Probiotic Bacterium Contrast Agents for Monitoring of Inflammation Associated Colitis Using Multispectral Optoacoustic Tomography: National Institute of Biomedical Imaging and Bioengineering (NIBIB): Federal: (Co-Investigator): R01 EB033919-01A1: 12% $766689: Awarded Detection of inflammation using noninvasive optoacoutic imaging and artificial intelligence: National Institute of Diabetes and Digestive and Kidney Diseases: R01DK131750-01A1: Pending Development of a Mini-probe for optoacoustic imaging: National Cancer Institute: Federal: R01CA268593 Actively targeted nanocontrast agents facilitate imageguided resection of pancreatic cancer National Cancer Institute: Principal Investigator: 2R01CA257862: Pending Monitoring neo-adjuvant treatment of breast cancer: National Cancer Institute: Federal: Principal Investigator: R01CA268375-A1: Pending Optoacoustic-Guided Surgical Resection: National Cancer Institute: Principal Investigator: R01CA271584: Pending

Lacey McNally, PhD (cont’d) Pancreatic Cancer Training Program: National Cancer Institute: T32CA258060- A1 Targeted Nanocontrast Facilitates Image-Guided Resection: National Cancer Institute: Principal Investigator: R01CA268989 Pending Non-invasive assessment of graft vs host disease using optoacoustic imaging: NIH: Co-Principal Investigator: R21CA271218 15% $352495: Awarded Multispectral optoacoustic tomography for the detection of extranodal extension in head and neck cancer: National Cancer Institute (NCI): Supporting Investigator: R21CA286276-01 Non-invasive assessment of graft vs host disease using optoacoustic imaging: NIH: Principal Investigator: R21CA271218 15% $169469 $116875: Awarded Tumor-Specific Nanocontrast Agents for Improved Detection of Pancreatic Cancer: Supporting Investigator: F31CA261044-01A1: Awarded Stroma targeted theranostic nanoparticles for pancreatic cancer: National Institutes of Health/ National Institute of Biomedical Imaging and Bioengineering: R01CA212350 5% $228750 $1694349: Awarded

Presentations

Frank Wood, MD Does Participation During Residency in University-Wide Leadership Councils Predict Graduate Retention?: Principal Investigator Principal Investigator (nonfunded) Effects of Historical Redlining and Gun Violence in Oklahoma City, Oklahoma: Principal Investigator (nonfunded) Penetrating Trauma in Children During the Covid-19 Era: Principal Investigator(non-funded) Does Residency Match Rank Order Predict Graduate Surgery Resident Performance?: Principal Investigator (non-funded) Utilization of Cardiopulmonary Bypass in Trauma Patients: Site PI (Non-Funded) Characterizing Patterns of Injury and Assessing Outcomes Associated with Burns Sustained While Smoking on Home Oxygen. Supporting Investigator (non-funded)

Guilherme Barreiro, MD Local-Lecture: Introduction to Plastic and Reconstructive Surgery: Plastic Surgery Interest Group Annual Conference: Section of Plastic Surgery, College of Medicine, University of Oklahoma: Oklahoma City, OK 1/1/24 International-Poster:Sensate Pedicled Anterolateral Thigh (ALT) Flap for Reconstruction of Pelvi-Perineal and Knee Region Defects: American Society for Reconstructive Microsurgery: Nassau, BS: 1/1/24 International-Poster: Superficial Superior Epigastic Flap: American Society for Reconstructive Microsurgery: Nassau, BS: 1/1/24 Kristina Booth, MD National-Grand Rounds: Entrustable Professional Activities: why, what, how and so what?: EPA Grand Rounds, Surgical Residency Program Invited Guest Lecture : Kaiser Permanente LAMC: Los Angeles, CA Virtual Grand Rounds: 11/12/24 National: Panel: Colon and Rectal Surgeons: The Bottom Line for Emergency Colon Surgery: American College of Surgeons (ACS) Clinical Congress 2024: American College of Surgeons (ACS): San Francisco, CA: 10/1/24 National: Oral Presentation: Comparing Level of Autonomy & Performance Amongst Surgical Residents Across Residencies Nationwide: Association of Program Directors in Surgery (APDS) - Surgical Education Week Paper Session III- Entrustable Professional Activities (EPA) and Competency Based Medical Education (CBME) Association of Program Directors in Surgery (APDS) Surgical Education Week: Hyatt Regency Orlando, FL: 4/26/24 National: Workshop: American Board of Surgery, Entrustable Professional Activites (EPAs): Department of Surgery, Indiana University, School of Medicine: Indianapolis, IN: 4/26/24 National: Workshop: EPAs Are Here: Strategies for Increasing Engagement and Meaningful Use at Your Institution: Association of Program Directors in Surgery (APDS) Entrustable Professional Activities (EPA): Workshop: The American Board of Surgery (ABS): School of Medicine, Indiana University: 4/26/24 Harold Burkhart, MD National: Oral Presentation: Repair of a Complex Unicuspid Aortic Valve using Geometric Ring Annuloplasty: STS2024 The 60th Annual Meeting: The Society of Thoracic Surgeons: San Antonio, Texas: 1/28/24 Juan Claros-Sorto, MD Regional: Lecture: Journey from Diagnosis to Survivorship: Project 31 Survivors Expo: P31: Oklahoma City: 6/22/24 Alisa Cross, MD National: Oral Presentation: Pediatric blunt thoracic aortic injuries: should management be driven by patient size or patient age?: Annual Pediatric Trauma Society: Pediatric Trauma Society: Charlotte, NC: 11/8/24 Local: Oral Presentation: Orthopedics Geriatric Hip Fracture Protocol: Orthopedic Department Lecture: Oklahoma University Health Sciences Center, College of Medicine, Department of Orthopedic Surgery: Oklahoma City: 7/15/24

Awards | Research | Grants | Publications | Presentations

Grants/Research

Presentations

Christian El Amm, MD International: Poster: Lengthening the hard palate European Cleft Palate Craniofacial Association: ECPCA: Milan, Italy: 6/25/24 International: Oral Presentation: Simulation, Virtual Reality (VR) and Augmented Reality (AR) in Cleft and Craniofacial Care – State of the Art and the Road Ahead: American Cleft Palate Craniofacial Association Annual Meeting: ACPA: Denver, CO: 4/11/24 Benjamin Greif, MD National: Oral Presentation: Pediatric blunt thoracic aortic injuries: should management be driven by patient size or patient age?: Pediatric Trauma Society, Annual Meeting: Pediatric Trauma Society: Charlotte, NC: 11/8/24 Catherine Hunter, MD National: Paper: Improving Survival at Quaternary Care NICUs Following Necrotizing Enterocolitis Totalis, a Condition Previously Considered 100% Lethal: International Pediatric Intestinal Failure and Rehabilitation Symposium: Pittsburg, PA: 9/27/24 Regional: Keynote/Plenary Address: Necrotizing Enterocolitis: Strides in Science and Surgery: Groff Lectureship: University of Louisville/ Norton Children's Hospital: Louisville, Kentucky: 6/7/24 International:Poster: Improving Survival at Quaternary Care NICUs Following Necrotizing Enterocolitis Totalis, a Condition Previously Considered 100% Lethal: Pediatric Academic Societies (PAS) 2024: Pediatric Academic Societies (PAS): Toronto, Canada: 5/1/24 National: Oral Presentation: Hyperinflammatory State Seen in Active Necrotizing Enterocolitis Remains Even Post Recovery: American Pediatric Surgical Association Annual Meeting: American Pediatric Surgical Association: Phoenix, AZ: 5/16/24 Local: Oral Presentation: Nasogastric Tubes: An Opportunity for Improved Understanding and Education: Partners in Quality Conference: Partners in Quality: Oklahoma City, OK: 3/12/24 Local: Poster: Randomized control trial of the Thopaz+ digital chest tube drainage system versus analog in pediatric patients: Partners in Quality Conference: Partners in Qualitiy, Oklahoma University Health Sciences Center: Virtual/Digital Presentation: 3/12/24 National: Accepted: Oral Presentation: Caveolin-1 Deficiency Effects on Tight Junctions and Apoptosis in Necrotizing Enterocolitis: Academic Surgical Congress SUS: Washington, DC: 2/8/24 National:Oral Presentation: Retained Hyperinflammatory State Post Recovery from Necrotizing Enterocolitis: Academic Surgical Congress: Academic Surgical Congress: Washington, DC: 2/7/24

Catherine Hunter, MD (cont’d) National: Poster: The Role of NADPH Oxidase's and their Contribution to Cell Death in Necrotizing Enterocolitis: Academic Surgical Congress: Academic Surgical Congress: Washington, DC: 2/7/24 National: Oral Presentation: Glutathione Peroxidase Two Gene Expression is Upregulated in Active Necrotizing Enterocolitis: Academic Surgical Congress: Academic Surgical Congress: Washington, DC: 2/6/24 Local: Oral Presentation: Caveolin-1 as a Regulator of Tight Junctions and Apoptosis in Necrotizing Enterocolitis: The Department of Pediatrics Annual Research Symposium: University of Oklahoma: Oklahoma City, OK: 2/2/24 Local: Poster: Glutathione Peroxidase Two Expression is Upregulated in Necrotizing Enterocolitis: The Department of Pediatrics Annual Research Symposium: University of Oklahoma, Department of Pediatrics: Oklahoma City, OK: 2/2/24 Local: Poster: Maternal Western Diet Increases Inflammatory Markers In Baboon Offspring: The Department of Pediatrics Annual Research Symposium: University of Oklahoma, Department of Pediatrics: Oklahoma City, OK: 2/2/24 Jeremy Johnson, MD National: Oral Presentation: Pediatric blunt thoracic aortic injuries: should management be driven by patient size or patient age?: Pediatric Trauma Society Annual Meeting: Pediatric Trauma Society: Charlotte, NC: 11/8/24 National: Oral Presentation: The ATOMAC criteria for pediatric blunt cerebrovascular injury: an ATOMAC multicenter study: Pediatric Trauma Society Annual Meeting: Pediatric Trauma Society: Charlotte, NC: 11/8/24 National: Abstract: An A+PTRN prospective/retrospective study of hypotensive children with blunt liver or spleen injury: Western Pediatric Trauma Conference: Sundance, UT: 7/14/24 Alessandra Landmann, MD National: Oral Presentation: Pediatric blunt thoracic aortic injuries: should management be driven by patient size or patient age?: Pediatric Trauma Society Annual Meeting: Pediatric Trauma Society: Charlotte, NC: 11/8/24 Jason Lees, MD National: Oral Presentation: Comparing Level of Autonomy & Performance Amongst Surgical Residents Across Residencies Nationwide: APDS- Surgical Education Week - Paper Session III - EPA and CBME APDS - Surgical Education Week: Hyatt Regency Orlando, FL: 4/26/24 Paul McGaha II, MD National: Oral Presentation: Pediatric blunt thoracic aortic injuries: should management be driven by patient size or patient age?: Pediatric Trauma Society Annual Meeting: Pediatric Trauma Society: Charlotte, NC: 11/8/24

Awards | Research | Grants | Publications | Presentations

Alisa Cross, MD (cont’d) Local: Panel: Schwartz Rounds: The Impact of Trauma on Caregivers: Schwartz Rounds: OU Health: 5/17/24 National: Oral Presentation: Risk Factors for In-Hospital Complications in Isolated Geriatric Hip Fractures: Southwest Surgical Congress: 4/24/24 International: Lecture: Nutrition in the Surgical Patient: American College of Surgeons Health Outreach: Program for Equity: American College of Surgeons Health Outreach Program for Equity’s (HOPE)/ NGO HMARIA Cyber Lecture Program Puerto Rico Medical Schools: Cyber/Puerto Rico Medical School: 1/30/24

Publications & Intellectual Contributions

Fernando Mier-Giraud, MD National: Oral Presentation: State of Bariatrics and Weight Loss Medicine: American College of Surgeons (ACS) Oklahoma Chapter: American College of Surgeons (ACS) Oklahoma Chapter: Oklahoma City, OK and Virtually: 5/22/24 National: Friday SAGES Video Reel (Non CME)/Oral Presentation: Robotic Sleeve Gastrectomy with Repair of Morgagni Hernia: 2024 Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) Annual Meeting: Society of American Gastrointestinal and Endoscopic Surgeons (SAGES): Cleveland, OH: 4/19/24

Narendra Battula, MD 39056458/10.1177/00031348241268273/Pardue, K., Timmerman, M., Elgenaid, S., Hassell, L. A., Battula, N. R., Pitchaimuthu, M. (2024). Successful Liver Transplant From a Donor With Sickle Cell Disease. The American surgeon, 31348241268273.

Chance Nichols, MD Local: Oral Presentation: "Penetrating Neck Trauma": Trauma Grand Rounds: University of Oklahoma Health Sciences Center: Oklahoma City, Oklahoma: 10/10/24 National: Oral Presentation: Not so FAST: Changes in the Diagnostic Yield of eFAST by Residents over the Academic Year: ACS Quality and Safety Conference: Denver Colorado: 7/20/24

Scott Blair, DO 39079438/10.1016/j.amjsurg.2024.115858 Snyder, K. B., Gushing, J., Quang, C. Y., Stewart, K. E., Sarwar, Z., Albrecht, R., Blair, S. G. (2024). Propofol administration for induction is associated with periintubation instability in trauma critical care unit patients. American journal of surgery, 238, 115858.

Maheswaran Pitchaimuthu, MD International: Lecture: Basics in Liver & Renal Transplant: Dhanalakshmi Srinivasan University Srinivasan Medical College and Hospital: Tamil Nadu, India: 1/1/24 Frank Wood, MD Local: Lecture: Ballistics and the Trauma Patient: Separating Fact from Fiction: OSU Paramedic Program: Oklahoma State University: Oklahoma State University - OKC Health Sciences Center: 10/23/24 Local: Panel: Program Director Panel on Residency Interviews: College of Medicine, University of Oklahoma: Oklahoma City, OK: 10/23/24 National: Lecture: A Pain in the Neck: Quail, Crush Syndrome, and the Treatment of Rhabdomyolysis: American Society of Anesthesia Technologists and Technicians 2024 Annual Meeting: Oklahoma City, Oklahoma: 9/26/24 State:Panel: Managing Subspecialty Emergencies: Trauma: Oklahoma Chapter of the American College of Surgeons 2024 Annual Meeting: Oklahoma City, Oklahoma: 8/3/24 Local: Lecture: Fasciotomy - Pearls and Pitfalls: Trauma Grand Rounds: Section of Acute Care Surgery, Department of Surgery, College of Medicine, University of Oklahoma: Oklahoma City, OK: 7/10/24

William Berry, PhD 38613944/PMC11097602/10.1016/j.molimm.2024.04.002 Ramakrishnan, G. S., Berry, W. L., Pacherille, A., Kerr, W. G., Chisholm, J. D., Pedicone, C., Humphrey, M. B. (2024).

SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology, 170, 35-45.

Kristina Booth, MD Booth, K. K. (2024). SCORE Question Bank. This Week in SCORES's Appendicicitis and Diverculitis Quiz.

Booth, K. K. (2024). This Week in SCORE’s Appendicitis and Diverticulitis quiz. "This Week in SCORE" Item Writer.

Harold Burkhart, MD 38196381/10.1017/S1047951123004432/Loeffler, K. A., Behere, S. P., Williams, P. K., Nakamura, Y., Burkhart, H. M., Campbell, M. D. (2024). Reduced morbidity with early surgical ligation of patent ductus arteriosus in extremely low birth weight infants: a retrospective single-centre study. Cardiology in the young, 1-6.

Alisa Cross, MD Martin, W. T., Snyder, K. B., Stewart, K. E., Sarwar, Z., Starr, W., Grady, A., Ball, J., Raines, A. R., Cross, A. M. (2024). Title: Bridging the Gap: Comparison of Outpatient Clinic and ED Patients Undergoing Cholecystectomy. Journal of Surgical Research, 300, 183-90.

William Dooley, MD 10.1158/1538-7445.sabcs23-po2-22-04/Schwartzberg, B., Syed, A. N., Bhatnagar, A., Rahman, S., Jones, V., Chang, A., Cockerham, T., Osborn, V., Cohen, R., Hodge, C., Lopez-Penalver, C., Chakravarthy, B., Dooley, W. C., Madu, C., Okabe, A., Farha, M., Madrigrano, A., Morrison, C., Neuner, G., Wengler, C., David, S., Toosie, K., Stephens, B. (2024). Abstract PO2-22-04: Median FiveYear Follow-Up Results from the Multi-Institution Trial for the Treatment of Early-Stage Breast Cancer Using Intra-Operative Electronic Brachytherapy. Cancer Research, 84(9_Supplement), PO2-22-04-PO2-22-04. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-22-04 38659868/PMC11042396/10.21203/rs.3.rs-4171651/v1/ Leslie, M., Pathak, R., Dooley, W. C., Squires, R. A., Rui, H., Chervoneva, I., Tanaka, T. (2024). Surgical DelayAssociated Mortality Risk Varies by Subtype in LocoRegional Breast Cancer Patients in SEER-Medicare..

Research square.

Awards | Research | Grants | Publications | Presentations

Presentations

Publications & Intellectual Contributions

Christian El Amm, MD El Amm, C. A. (2024). How I Do It: Lateral Canthopexy.

ISCFS Newsletter.

El Amm, C. A. (2024). New Technologies: Preoperative Marking Gets a Technological Boost. ISCFS Newsletter.

Joshua Gierman, MD 39650167/PMC11624567/10.1177/2050313X241297217/ Evans, A. R., Kharbat, A. F., Gierman, J. L., Shakir, H. J. (2024). Intravascular lithotripsy prior to transcarotid arterial revascularization: A technical tale of two cases.

SAGE open medical case reports, 12, 2050313X241297217. https://www.avensonline.org/wp-content/uploads/ JSUR-2332-4139-12-0058.pdf/Snyder, K. B., Farnell, C., Buonpane, C. (2024). Open Repair of Pediatric Aortoenteric Fistula from A Remote Gastric Transposition in Congenital Esophageal Atresia: A Multidisciplinary Approach. Journal of Surgery, 12(1), 1-3. https://www.avensonline.org/wp-content/ uploads/JSUR-2332-4139-12-0058.pdf Benjamin Greif, MD 38544967/PMC10965468/10.1016/j.jvscit.2024.101463/ AbouAyash, J., Greif, B. A., Salzler, G., Ryer, E., Garvin, R. (2024). Transcervical approach to distal extracranial internal carotid aneurysm. (3rd ed., vol. 10, pp.

101463). Journal of vascular surgery cases and innovative techniques.

38510087/PMC10950828/10.1016/j.jvscit.2024.101456/ Kerr, J. P., Greif, B. A., Salzler, G. G., Ryer, E. J., Garvin, R. P. (2024). Coronary stent migration to aorta with successful recovery during aortobifemoral bypass. (3rd ed., vol. 10, pp. 101456). Journal of vascular surgery cases and innovative techniques.

Arthur Grimes, MD 10.1007/s40137-024-00414-y/Follette, C. J., Grimes, A., Detelich, D. M., Martin, R. S. (2024). Finding Value in Emergency General Surgery. Current Surgery Reports, 12(8), 245-251. https://api.elsevier.com/content/ abstract/scopus_id/85195907098

Arthur Grimes, MD (cont’d) 10.1177/00031348241227195/Harrell, K. N., Grimes, A., Gill, H., Reynolds, J. K., Ueland, W. R., Sciarretta, J. D., Todd, S. R., Trust, M. D., Ngoue, M., Thomas, B. W., Ayuso, S. A., LaRiccia, A., Spalding, C. M., Collins, M. J., Collier, B. R., Karam, B. S., de Moya, M. A., Lieser, M. J., Chipko, J. M., Haan, J. M., Lightwine, K. L., Cullinane, D. C., Falank, C. R., Phillips, R. C., Kemp, M. T., Alam, H. B., Udekwu, P. O., Sanin, G. D., Hildreth, A. N., Biffl, W. L., Schaffer, K. B., Marshall, G., Muttalib, O., Nahmias, J., Shahi, N., Moulton, S. L., Maxwell, R. A. (2024). Bone Anchor Fixation in the Repair of Blunt Traumatic Abdominal Wall Hernias: A Western Trauma Association Multicenter Study. American Surgeon, 90(6), 1161-1166. https://api.elsevier.com/content/abstract/ scopus_id/85182213207 10.1093/jscr/rjae296/Blum, B., Grimes, A., Carroll, H. L., Stettler, G. R. (2024). Cecal volvulus secondary to mesodiverticular band. Journal of Surgical Case Reports, 2024(5). https://api.elsevier.com/content/ abstract/scopus_id/85192708820 10.1136/tsaco-2024-001394/Grimes, A., Stettler, G. R., Nunn, A. M. (2024). Immediate chest wall stabilization following thoracotomy for hemorrhage in severe blunt thoracic trauma (1st ed., vol. 9). Trauma Surgery and Acute Care Open. https://api.elsevier.com/content/ abstract/scopus_id/85186962557 Catherine Hunter, MD 10.1089/sur.2024.54642.rfs2023 Hunter, C. J. (2024). Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for Surgical Infections. Surgical Infections, 25(7), 477-477. https:// doi.org/10.1089/sur.2024.54642.rfs2023 39125983/10.3390/ijms25158416/Gershner, G. H., Hunter, C. J. (2024). Redox Chemistry: Implications in Necrotizing Enterocolitis. International Journal of Molecular Sciences, 25(15), 8416. https:// doi.org/10.3390/ijms25158416 10.1007/s43681-024-00525-3/Snyder, K. B., Stewart, R. A., Hunter, C. J. (2024). Ethical considerations for the application of artificial intelligence in pediatric surgery.

AI and Ethics. https://doi.org/10.1007/ s43681-024-00525-3 https://doi.org/10.21037/pm-22-41/Snyder, K. B., Hunter, C. J. (2024). The leaky gut: a narrative on the role of epithelial permeability in necrotizing enterocolitis.

Pediatric Medicine, 7.

38653916/DOI: 10.1007/s40272-024-00630-0 Snyder, K. B., Hunter, C. J., Buonpane, C. (2024).

Perforated Appendicitis in Children: Management, Microbiology and Antibiotic Stewardship. Paediatric Drugs, 3, 277-286.

38284399/10823418/Hunter, C. J., Naumann, D. (2024).

Novel Textbook Outcomes for emergency laparotomy in both trauma and non-trauma settings: a Delphi exercise.

British Journal of Surgery. https://www.avensonline.org/wp-content/uploads/ JSUR-2332-4139-12-0058.pdf/Snyder, K. B., Farnell, C., Buonpane, C. (2024). Open Repair of Pediatric Aortoenteric Fistula from A Remote Gastric Transposition in Congenital Esophageal Atresia: A Multidisciplinary Approach. Journal of Surgery, Volume 12(Issue 1), 1-3. https://www.avensonline.org/wp-content/uploads/ JSUR-2332-4139-12-0058.pdf

Awards | Research | Grants | Publications | Presentations

Barish Edil, MD 38429478/10.1038/s41556-024-01372-4/Murthy, D., Attri, K. S., Shukla, S. K., Thakur, R., Chaika, N. V., He, C., Wang, D., Jha, K., Dasgupta, A., King, R. J., Mulder, S. E., Souchek, J., Gebregiworgis, T., Rai, V., Patel, R. J., Hu, T., Rana, S., Kollala, S. S., Pacheco, C., Grandgenett, P. M., Yu, F., Kumar, V., Lazenby, A. J., Black, A. R., Ulhannan, S., Jain, A., Edil, B. H., Klinkebiel, D. L., Powers, R., Natarajan, A., Hollingsworth, M. A., Mehla, K., Ly, Q., Chaudhary, S., Hwang, R. F., Wellen, K. E., Singh, P. K. (2024). Cancer-associated fibroblastderived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nature cell biology.

Publications & Intellectual Contributions

10.1093/bjsopen/zrad145/Naumann, D. N., Bhangu, A., Brooks, A., Martin, M., Cotton, B. A., Khan, M., Midwinter, M. J., Pearce, L., Bowley, D. M., Holcomb, J. B., Griffiths, E. A., Abu-Abeid, A., Brooks, A., Peckham-Cooper, A., Dyas, A. R., Adeyeye, A., Dogjani, A., Ball, A. C., Wolthuis, A. M., Quiroga-Garza, A., Karamarkovic, A. R., Giordano, A., Fuchs, A., Julianov, A., Phillips, A. W., Zimmermann, A., Charalabopoulos, A., Birkun, A. A., Narvaez-Rojas, A. R., Guner, A., Davis, A. L., Vereczkei, A., Balla, A., Celotti, A., Romanzi, A., Trombetta, A., Beggs, A. D., Robertson, A. G., Petrosoniak, A., Davies, A. R., Becerra-Bolaños, Á., Loria, A., Brillantino, A., Athanasiou, A., Isik, A., Ioannidis, A., Santos, A. P., Saha, A. K., Vilches-Moraga, A., Choudhry, A. J., Tsuchiya, A., Smithers, B. M., Wijnhoven, B. P., Keeler, B. D., De Simone, B., Birla, R., Mitra, B., Atanasov, B. C., Badgwell, B., Nolan, B., Cotton, B. A., Kang, B. H., Duffy, C. C., Ordoñez, C. A., Gomes, C. A., Mueller, C. L., Reinke, C. E., Lebares, C. C., Hunter, C. J., Villodre, C., Guldogan, C. E., Seretis, C., Adams, C. A., Pilgrim, C. H., Varghese, C., Owoo, C., Meyhoff, C. S., Fleming, C. A., Stuart, C. M., Lewis-Lloyd, C. A., McLaughlin, C. J., Stevens, C. L., Graham, C. A., Magee, C., Saunders, D. I., Yeh, D. D., Chan, D. L., Felsenreich, D. M., Holena, D. N., Bawa, D., Bowrey, D. J., Naumann, D. N., Liu, D. S., Chan, D. S., Nag, D. S., Haddad, D. N., Corallino, D., Damaskos, D., Moris, D., Schizas, D., Korkolis, D. P., Bagaria, D. K., Adamovich, D. M., Colquhoun, D. A., Bowley, D. M., Singhal, D., Siddaiah-Subramanya, M., Kapoor, R., Wyncoll, D., Hai, D. V., Avest, E. T., Muttillo, E. M., Picetti, E., Kelly, E., Baili, E., Pinto, E., Colak, E., Dixon, E., Reitano, E., Sultana, E., Mills, E. C., Ley, E. J., Osterman, E., Pivalizza, E. G., Tokidis, E., Griffiths, E. A., Ezanno, A.-C., Catena, F., Pederiva, F., Coccolini, F., Nickel, F., Agresta, F., Tovar, F. N., Abu-Zidan, F. M., Brzeszczyński, F., El Boghdady, M., Takeda, F. R., Fleres, F., Pecchini, F., Carrano, F. M., Pata, F., Mulita, F., Klevebro, F., Rodrigues, G., Gallo, G., Poillucci, G., Bass, G. A., Aggarwal, G., Perrone, G., Roberts, G., Koukoulis, G., Zacharis, G., Baiocchi, G. L., Pellino, G., Lisi, G., Dapri, G., Brisinda, G., Augustin, G., Christodoulidis, G., Imbriaco, G., Ducarme, G., Rasa, H. K., Hamer, P. W., Lederhuber, H., Plaudis, H., Uchino, H., Beji, H., Ferguson, H. J., Cohen, H. M., Wilson, I., Kryvoruchko, I. A., Kuitunen, I., Benzoni, I., Merlini, I., Ose, I., Wani, I., Gockel, I., Negoi, I., Gribovskaja-Rupp, I., Tomasi, I., Olaoye, I. O., Kenington, J. C., Roth, J. S., Rosenberg, J., Viganò, J., Williamson, J. M., De Waele, J. J., Smith, J. E., Nahmias, J., Stevens, J. L., Rickard, J., Mah, J. J., Waalwijk, J. F., Yuval, J. B., Kauppila, J. H., Cuschieri, J., Brown, J. B., Rivas, J. G., Emamaullee, J., Lasithiotakis, K., McKenzie, K., Matsushima, K., Koivusalo, A. I., Almond, L. M., Konge, L., Jorgensen, L. N., Genser, L., Napolitano, L. M., Brown, L. R., Kaplan, L. J., Degrate, L., Bonavina, L., Moore, L., Gachabayov, M., Dornseifer, M. D., Siddaiah-Subramanya, M., Abdulshafea, M., Ribeiro Junior, M. A., Migliore, M., Ceresoli, M., Clementi, M., Scarpa, M., Olausson, M., Sousa, M. R., Giuffrida, M., D'Oria, M., Pacilli, M., Czerny, M., Reichert, M., Rutegård, M., Bahreini, M., Lee, M. J., Martin, M. J., Tolonen, M., Fehervari, M., Rho, M., Podda, M., Léger, M., Frountzas, M., Chisthi, M. M., Lewis, M. R., Bérubé, M., Oliveira-Cunha, M., Marsden, M. E., Tez, M., Piccoli, M., Bath, M. F., Flanagan, M., Gottlieb, M., Pearl, M. L., Achiam, M. P., Swart, M., Ukkonen, M., Bala, M., Ebrahim, M., AlAli, M. N., Ortenzi, M., Ghalleb, M., Hylander Møller, M., Iqbal, M. R., Ali, M. A., Tarazi, M., Newton, N. J., Hanna, N. M., Henriksen, N. A., Blencowe, N. S., Merrett, N., Welch, N. T., Colucci, N., de'Angelis, N., Latronico, N., Werner, N. L., Martin, N. D., Machairas, N., Bugaev, N., Pang, N. Q., Obinwa, O., Akanji, O. O., Kapsampelis, P., De Nardi, P., Vincenzi, P., Kohan, P. L., Pucher, P. H., Herrod, P. J., CHIU, P. W., Marzuillo, P., Sileri, P., Fransvea, P., Navsaria, P. H., Valentin, P. D., Bakx, R., Choron, R. L., Gupta, R., Ivatury, R. R., Diaz, R., Bradley, R. A., Elisa, R., Palacios Huatuco, R. M., Shahriarirad, R., Rattan, R., Karmy-Jones, R., Sawyer, R. G., Coelen, R. J., Cirocchi, R., Gelbard, R. B., Zakeri, R., Farinha, R., Schols, R. M., Dumas, R. P., Saverio, S. D., Bandyopadhyay, S. K., Delibegovic, S., Stevens, S., Navarro, S. M., Chatterjee, S., Petousis, S., Gourgiotis, S., Streit, S. M., Baral, S., Karna, S. T., Moug, S., Yoong, S., Gisbertz, S. S., Kheirbek, T., Jeremy, T. Y.-C., Duane, T. M., Jensen, T. K., Bright, T., Hardcastle, T. C., Tania, T., Nikolian, V. C., Bianchi, V., Kong, V., Trapani, V., Shelat, V. G., Mani, V. R., Khokha, V. M., Yang, W., Al-Khyatt, W., Lam, Y. H., Kijima, Y., Cui, Y., Perkins, Z. B., Demetrashvili, Z., Ng, Z. Q. (2024). Novel Textbook Outcomes following emergency laparotomy: Delphi exercise. BJS Open, 8(1). https://doi.org/10.1093/bjsopen/zrad145

Ajay Jain, MD 38429478/10.1038/s41556-024-01372-4/Murthy, D., Attri, K. S., Shukla, S. K., Thakur, R., Chaika, N. V., He, C., Wang, D., Jha, K., Dasgupta, A., King, R. J., Mulder, S. E., Souchek, J., Gebregiworgis, T., Rai, V., Patel, R. J., Hu, T., Rana, S., Kollala, S. S., Pacheco, C., Grandgenett, P. M., Yu, F., Kumar, V., Lazenby, A. J., Black, A. R., Ulhannan, S., Jain, A., Edil, B. H., Klinkebiel, D. L., Powers, R., Natarajan, A., Hollingsworth, M. A., Mehla, K., Ly, Q., Chaudhary, S., Hwang, R. F., Wellen, K. E., Singh, P. K. (2024). Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis.

Nature cell biology.

Jeremy Johnson, MD 38295192/10.1097/PEC.0000000000003116/Leiva, T., Golubkova, A., Snyder, K., Johnson, J. J., Hunter, C. J. (2024). Pediatric Traumatic Lumbar Hernias and Associated Injuries: A Case Series. Pediatric emergency care, 40(2), 103-107.

38189680/10.1097/TA.0000000000004228/Naiditch, J. A., Notrica, D. M., Sayrs, L. W., Linnaus, M., Stottlemyre, R., Garcia, N. M., Lawson, K. A., Cohen, A. S., Letton, R. W., Johnson, J. J., Maxson, R. T., Eubanks, 3rd, J. W., Ryan, M., Alder, A., Ponsky, T. A., St Peter, S. D., Bhatia, A. M., Leys, C. M. (2024). The use and timing of angioembolization in pediatric blunt liver and spleen injury.

The journal of trauma and acute care surgery.

Alessandra Landmann, MD 10.1016/j.jpedsurg.2024.161997/Snyder, K. B., Phillips, R., Stewart, K. E., Sarwar, Z., Hunter, C. J., Landmann, A., Albrecht, R., Johnson, J. J. (2024). SIPA Poorly Predicts Outcomes in Young Pediatric Trauma Patients. Journal of Pediatric Surgery, 161997. http://dx.doi.org/10.1016/ j.jpedsurg.2024.161997 https://www.avensonline.org/wp-content/uploads/ JSUR-2332-4139-12-0058.pdf/Snyder, K. B., Farnell, C., Buonpane, C. (2024). Open Repair of Pediatric Aortoenteric Fistula from A Remote Gastric Transposition in Congenital Esophageal Atresia: A Multidisciplinary Approach. Journal of Surgery, 12(1), 1-3. https:// www.avensonline.org/wp-content/uploads/ JSUR-2332-4139-12-0058.pd Min Li, PhD 10.1002/adfm.202410079/Hoover, A., Liu, K., Furrer, C., Lam, S., Anderson, D., Zhou, Z., Yang, J., Wong, C., Medcalf, A., Sun, X., Hode, T., Alleruzzo, L., Delawder, A., Raker, J., Abousleiman, G., Valerio, T., Sun, Y., Papin, J., Li, M., Chen, W. (2024). N-Dihydrogalactochitosan Drives Conventional and Alternative Activations of STING to Synergize Type I IFN and IL-1β Productions for Antitumor Immunity. ADVANCED FUNCTIONAL MATERIALS. 39688909/10.1172/jci.insight.186565/Fu, H., Cai, Q., Zhou, Z., He, Y., Li, M., Yang, D. (2024). Orthotopic gastric cancer mouse model identifies trajectory of lymphatic metastasis. JCI insight.

39307410/PMC11471373/10.1016/j.canlet.2024.217267/ Liu, K., Hoover, A. R., Wang, L., Sun, Y., Valerio, T. I., Furrer, C., Adams, J., Yang, J., Li, M., Chen, W. R. (2024).

Localized ablative immunotherapy enhances antitumor immunity by modulating the transcriptome of tumorinfiltrating Gamma delta T cells. Cancer letters, 604, 217267.

Awards | Research | Grants | Publications | Presentations

Catherine Hunter, MD (cont’d) 38295192/10.1097/PEC.0000000000003116/Leiva, T., Golubkova, A., Snyder, K., Johnson, J. J., Hunter, C. J. (2024). Pediatric Traumatic Lumbar Hernias and Associated Injuries: A Case Series. Pediatric emergency care, 40(2), 103-107.

38250141/Snyder, K., Calkins, C., Golubkova, A., Leiva, T., Schlegel, C., Hunter, C. J. (2024). Despite Recovery from Necrotizing Enterocolitis Infants Retain a Hyperinflammatory Response to Injury. J Inflamm Res.

Publications & Intellectual Contributions

Suhair Maqusi, MD 39220674/PMC11364467/10.1055/a-2376-7197/ Stevens, B. E., Bialek, S., Zhao, K., Maqusi, S., Rassi, E. E., Tan, J., Graffeo, C. (2024). Profound Pneumocephalus and Low-Pressure Hydrocephalus Triggered by Ventriculoperitoneal Shunt Placement after Resection, Fat Graft Reconstruction, and Radiotherapy for a Malignant Skull Base Schwannoma.

Journal of neurological surgery reports, 85(3), e138e143.

Lacey McNally, PhD Holter, J. L. (2024). 18F-FLT PET and Blood-based Biomarkers for Identifying Gastrointestinal Graft versus Host Disease after Allogeneic Cell Transplantation.

Radiology Imaging Cancer, 7, e240096.

MacCuaig, W. M., McNally, L. R. (2024). Influence of structural moieties in squaraine dyes on optoacoustic signal shape and intensity. Chem, 10(2), 713-729.

Agarwal, H., McNally, L. R. (2024). Theranostic nanoparticles for detection and treatment of pancreatic cancer. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 16, e1983.

Fernando Mier-Giraud, MD 38869833/10.1007/s11695-024-07296-0/Martinino, A., Nanayakkara KDL, Madhok, B., Wong GYM, Abouelazayem, M., Pereira JPS, Wazir, I., Balasubaramaniam, V., Said, A., Marques, C., Abdelbaeth, A., Al-Shami, K., Albashari, M., Alkaseek, A., Almayouf, M. A., Aloulou, M., Alqahtan, A. R., Askari, A., Attia MFA, Awad, A. K., Aykota, M. R., Bacalbasa, N., Barrera-Rodriguez, F. J., Benavoli, D., Billa, S., Borrelli, V., Çalıkoğlu, İ., Campanelli, M., Carbajo, M. A., Chowdhury, S., Cristin, L., Dapri, G., Dong, Z., Elfawal, M. H., Elgazar, A., Elhadi, M., Gentileschi, P., Graham, Y., Haj, B., Johnson, J. A., Kalmoush, A. M., Kamal, A., Kamocka, A., Khamees, A., Lisi, G., Hernandez EEL, Marinari, G. M., Martines, G., Meric, S., Mier, F., Ali, A. M., Mohammed, D., Mohamed, K. M., Mulita, F., Musella, M., O'Malley, W. E., Olmi, S., Omarov, T., Osama, O., Perera, H. R., Piscitelli, G., Poghosyan, T., Ramírez, D., Rezvani, M., Ribeiro, R., Sabbota, A., Sakran, N., Sawaftah, K. A., Schiavone, K., Şen, O., Sotiropoulou, M., Tartaglia, N., Tokocin, M., Trotta, M., Türkçapar, A. G., Uccelli, M., Vargas, C., Verras, G., Wang, C., Wei, Z., Yang, W., Zerrweck, C., Owen, E., Gkoutos, G. V., Cardoso, V. R., Singhal, R., Mahawar, K. (2024). Global 30-Day Morbidity and Mortality of Primary Bariatric Surgery Combined with Another Procedure: The BLEND Study. Obesity surgery.

Maheswaran Pitchaimuthu, MD 39056458/10.1177/00031348241268273/Pardue, K., Timmerman, M., Elgenaid, S., Hassell, L. A., Battula, N. R., Pitchaimuthu, M. (2024). Successful Liver Transplant From a Donor With Sickle Cell Disease. The American surgeon, 31348241268273.

Celia Quang, MD 10.1016/j.amjsurg.2024.115858/Snyder, K., Gushing, J., Quang, C., Stewart, K. E., Sarwar, Z., Albrecht, R., Blair, S. (2024). Propofol administration for induction is associated with peri-intubation instability in trauma critical care unit patients. AMERICAN JOURNAL OF SURGERY, 238.

Matthew J. Reinersman, MD 38564059/10.1007/s11701-024-01898-7/Trimble, E. J., Stewart, K. E., Reinersman, J. M. (2024). Early comparison robotic bronchoscopy versus electromagnetic navigational bronchoscopy for biopsy of pulmonary nodules in a thoracic surgery practice.

Journal of robotic surgery, 18(1), 149.

Jess Schwartz, MD 10.1201/9781003526384-4/Parasher, G., Schwartz, J. D. (2024). Complications of Esophageal Stents and Their Management. Self-Expanding Stents in Gastrointestinal Endoscopy (pp. 59-76). CRC Press. https:// doi.org/10.1201/9781003526384-4 Kenneth Stewart. PhD. 10.1016/j.amjsurg.2024.115858/Snyder, K. B., Gushing, J., Quang, C. Y., Stewart, K. E., Sarwar, Z., Albrecht, R., Blair, S. G. (2024). Propofol administration for induction is associated with peri-intubation instability in trauma critical care unit patients. American Journal of Surgery, 238. https://api.elsevier.com/content/abstract/ scopus_id/85199778088 Emily Switzer, MD 10.1177/00031348241256084/Sullivan, B. G., Delaplain, P. T., Manasa, M., Tay-Lasso, E., Biffl, W. L., Schaffer, K. B., Sundel, M., Behdin, S., Ghneim, M., Costantini, T. W., Santorelli, J. E., Switzer, E. E., Schellenberg, M., Keeley, J. A., Kim, D. Y., Wang, A., Dhillon, N. K., Patel, D., Campion, E. M., Robinson, C. K., Kartiko, S., Quintana, M. T., Estroff, J. M., Kirby, K. A., Nahmias, J. (2024). An Abdominal Seat Belt Sign is Associated With Similar Incidence of Hollow Viscus Injury but Increased In-Hospital Mortality in Older Adult Trauma Patients: A PCSA Multicenter Study. The American surgeon, 90(11), 2840-2847. https:// api.elsevier.com/content/abstract/ scopus_id/85206018200 Frank Wood, MD Wood, F. C. (2024). SCORE School: Airway Access, Intubation, and Surgical Airways. The SCORE Portal. http://www.surgicalcore.org

Awards | Research | Grants | Publications | Presentations

Min Li, PhD (cont’d) 39217610/PMC11403044/10.1016/j.xpro.2024.103281/ Zhou, Z., Yang, J., Liu, M., Ren, Y., Shi, X., Cai, Y., Arreola, A. X., Li, Y. P., Zhang, Y., Li, M. (2024). Protocol for establishing and evaluating a cancer cachexia mouse model. STAR protocols, 5(3), 103281.

38608702/PMC11162958/10.1016/j.ccell.2024.03.009/ Liu, M., Ren, Y., Zhou, Z., Yang, J., Shi, X., Cai, Y., Arreola, A. X., Luo, W., Fung, K.-M., Xu, C., Nipp, R. D., Bronze, M., Zheng, L., Li, Y. P., Houchen, C. W., Zhang, Y., Li, M. (2024). The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia.

Cancer cell, 42(5), 885-903.e4.

38341126/10.1016/j.canlet.2024.216722/Li, M. (2024).

Half century of cancer research: In honor of Dr.rer.nat Manfred Schwab, the former Editor-in-Chief of Cancer Letters. (vol. 585, pp. 216722). Cancer letters.

Events

2024 Grand Rounds & Lectureships

2024 Chief Resident Farewell Breakfast

Christopher Jeffery, MD Plastic Surgery Fellowship University of Oklahoma Oklahoma City, OK

Connor Wilkinson, MD Private Practice General Surgery Comanche County Memorial Hospital Lawton, OK

Taylor Wilkinson, MD Colorectal Surgery Fellowship University of Tennessee Chattanooga, TN

Lily Nguyen, MD Private Practice General Surgery College Station, TX

Samara Lewis, MD Private Practice General Surgery Topeka, KS

2024 Chief Surgical Residents & Fellows Graduation Banquet

2024 Chief Surgical Residents & Fellows Graduation Banquet

Resident Paper Airplane Golf Competition

2024 Staff Celebrations

2024 Christmas

Giving Surgeons at the University of Oklahoma Health Sciences Center are dedicated to excellence in education, research and patient care. We appreciate the generous support of patients and their families, alumni, physicians, friends and businesses.

Your gift can help improve a child’s health, award a resident a scholarship, or provide funds for research, equipment, computers, library materials and more. Every gift we receive makes a difference, and we sincerely thank you for your generosity.

Development Office University of Oklahoma Health Sciences Center P.O. Box 26901 Oklahoma City, OK 73126 405-271-2300

http://home.oufoundation.org/COMSurgery

If you would like to contribute an article, news item or event notice for our newsletter, please email: jessica-capetillo@ouhsc.edu

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