OU Surgery News Fall/Winter 2021

SURGERY NEWS Fall/Winter 2021

Issue No. 6

Letter from the Chair Department of Surgery 2021 Overview Division of Cardiac, Thoracic & Vascular Surgery Division of General Surgery/Trauma Surgery/Critical Care Division of Pediatric Surgery Division of Plastic & Reconstructive Surgery

Division of Surgical Oncology Division of Transplant Surgery Administration Education Research Events

MESSAGE FROM THE CHAIR

Welcome to the final newsletter of 2021. It is nice to see us slowly exiting the pandemic and entering a more recognizable reality. During this year we continued to excel with our missions, grew as a department, and added to our individual accomplishments.

I would like to highlight the return of Research Day. The research presented was not only informative, but the level of sophistication was impressive. Dr. Herb Chen, from the University of Alabama, capped the day with a Grand Rounds that had many universal lessons, which I am sure, impacted the faculty and residents.

The Department of Surgery continues to grow and we are now at 61 clinical faculty. I would like to welcome Dr. Ahsan, Dr. Andacoglu, and Dr. Oseini who have joined the Transplant Division. These talented faculty members will be a welcome addition as the Transplant Service Line accelerates towards regional dominance. I would like to also welcome back Dr. Landmann as she joins the Pediatric Surgery Division, I know she will accomplish great goals.

Finally, I would like to thank the entire department for your poise, patience, and perseverance as our academic landscape is continually shifting. I am extremely proud of your leadership, academic vigor, and dedication to our students and residents.

Barish H. Edil, MD Professor & Chair

To learn more about the University of Oklahoma and the Department of Surgery, visit https://medicine.ouhsc.edu/Academic-Departments/Surgery

DEPARTMENT MISSION STATEMENT To improve the health of all people, to deliver excellent, innovative patient care, and to educate physicians and surgeons for the future

Clinical Faculty: 61

Total Staff including Advance Practice Providers: 91

Number of Residents: 31

Number of Fellows: 7

Total Number of Clinic Visits: 23,280 Total wRVUs: 198,217.58 Total Number of OR Cases: 33,781

Division of Cardiac, Thoracic & Vascular Surgery

Harold Burkhart, MD Professor and Division Chief Acting CEO, OU Health Pediatric Cardiothoracic Surgical Program Director CHF Brandon Weeden Chair in Pediatric Cardiac Surgery

Clinical Faculty Pediatric Cardiac Surgery Harold Burkhart, MD Yuki Nakamura, MD

Adult Cardiac Surgery Lacy Harville, MD

Thoracic Surgery Argenis Herrera, MD J. Matthew Reinersman, MD

Vascular Surgery Joshua Gierman, MD

DIVISION BY THE NUMBERS January 1, 2021 - December 31, 2021

**Decreased numbers attributed to COVID-19 and its impact on healthcare globally

OR Cases Cardiac Surgery 2,793

Thoracic 1,210

Vascular Surgery 872

Thoracic 15,698.38

Vascular Surgery 9,424.34

Thoracic 1,953

Vascular Surgery 696

wRVUs Cardiac Surgery 45,193.19

Clinical Visits Cardiac Surgery 446

New Hires AnnMarie Alexander, PA-C Iryna Bilga, PA-C Grace Lawson, APRN

Awards & Recognition Harold Burkhart, MD Acting Chief Executive Officer, OU Health Alpha Omega Alpha Honor Society member American Board of Thoracic Surgery Congenital Heart Surgery Written Exam Consultant 2021 - 405 Magazine Oklahoma City Top Doc American Association for Thoracic Surgery Congenital Education Committee member Oklahoma University Health Enterprise Leadership Development Institute (LDI) Council member Lacy Harville, MD 2021 Academy of Teaching Scholars Education Hero Award Yuki Nakamura, MD 2021 Surgery Pilot Grant Award Recipient J. Matthew Reinersman, MD Promoted to Associate Professor

Grants Harold Burkhart, MD Principle Investigator Presbyterian Health Foundation 07/2021 – 06/2022 Probabilistic in-Silico Modeling – Guided Management of Tricuspid Regurgitation in Hypoplastic Left Heart Syndrome Year 3 Science Grant $100,000.00

Presentations Harold Burkhart, MD Congenital Heart Disease-Surgical Palliation and Treatment, Mend a Heart 1 Lecture Series, March 23, 2021 Congenital Heart Disease-Surgical Corrections, Mend a Heart 1 Lecture Series, Oklahoma City, March 25, 2021 Challenges in Single Ventricle Psychology, American Association for Thoracic Surgery 101st Annual meeting, April 30, 2021 Joshua Gierman, MD Spontaneous Ulnar Artery Pseudoaneurysm: A Case Report, Texas Society for Vascular & Endovascular Surgery, November 5, 2021

Publications Harold Burkhart, MD Burkhart HM, Nakamura Y, Mir A. Commentary: Arterial switch operation: It's the little things that count.

JTCVS Tech. 2021 Sep 28;10:446-447. doi: 10.1016/j.xjtc.2021.09.042. PMID: 34977779; PMCID: PMC8691824.

Ross CJ, Laurence DW, Echols AL, Babu AR, Gu T, Duginski GA, Johns CH, Mullins BT, Casey KM, Laurence KA, Zhao YD, Amini R, Fung KM, Mir A, Burkhart HM, Wu Y, Holzapfel GA, Lee CH. Effects of enzyme-based removal of collagen and elastin constituents on the biaxial mechanical responses of porcine atrioventricular heart valve anterior leaflets.

Acta Biomater. 2021 Nov;135:425-440. doi: 10.1016/j.actbio.2021.08.043. Epub 2021 Sep 2.

PMID: 34481053.

Burkhart HM, Mir A, Nakamura Y. Commentary: Congenital aortic arch reconstruction: Keeping the window open. JTCVS Tech. 2021 Jun 15;8:132-134. doi: 10.1016/j.xjtc.2021.06.006. PMID: 34401833; PMCID: PMC8350942.

Mir A, Burkhart HM. Commentary: Complex transposition: Preparing for success. JTCVS Tech. 2021 Feb 27;7:206-207. doi: 10.1016/j.xjtc.2021.02.036.

PMID: 34318248; PMCID: PMC8311826.

Burkhart HM, Nakamura Y, Behere SP. Commentary: Refining the reimplantation technique for anomalous aortic origin of a coronary artery. JTCVS Tech. 2021 Feb 20;7:231-232. doi: 10.1016/j.xjtc.2021.02.020.

PMID: 34318257; PMCID: PMC8311705.

Publications

Publications

Harold Burkhart, MD Stevens B, Buckley K, Schwartz R, Burkhart H. The Successful Use of an Exchange Transfusion in a Child with Hereditary Spherocytosis Undergoing Congenital Cardiac Surgery. J Extra Corpor Technol. 2021 Jun;53(2):137-139. doi: 10.1182/ject-2000060. PMID: 34194080; PMCID: PMC8220905.

Ross CJ, Mullins BT, Hillshafer CE, Mir A, Burkhart HM, Lee CH. Evaluation of affine fiber kinematics in porcine tricuspid valve leaflets using polarized spatial frequency domain imaging and planar biaxial testing. J Biomech. 2021 Jun 23;123:110475. doi: 10.1016/j.jbiomech.2021.110475. Epub 2021 Apr 30.

PMID: 34004393.

Drennan SE, Burge KY, Szyld EG, Eckert JV, Mir AM, Gormley AK, Schwartz RM, Daves SM, Thompson JL, Burkhart HM, Chaaban H. Clinical and Laboratory Predictors for the Development of Low Cardiac Output Syndrome in Infants Undergoing Cardiopulmonary Bypass: A Pilot Study. J Clin Med. 2021 Feb 11;10(4):712. doi: 10.3390/jcm10040712. PMID: 33670210; PMCID: PMC7916966.

Burkhart HM, Qureshi MY. Commentary: Defining the role of stem cell therapy in neonatal cardiac regeneration. J Thorac Cardiovasc Surg. 2022 Jan;163(1):249-250. doi: 10.1016/j.jtcvs.2020.09.013.

Epub 2020 Sep 10. PMID: 33618871.

Johnson EL, Laurence DW, Xu F, Crisp CE, Mir A, Burkhart HM, Lee CH, Hsu MC. Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves. Comput Methods Appl Mech Eng. 2021 Oct 1;384:113960. doi: 10.1016/j.cma.2021.113960. Epub 2021 Jun 17.

PMID: 34262232; PMCID: PMC8274564.

Burkhart HM, Anderson HN. Commentary: Complete atrioventricular septal defect in young infants: The advantages of early repair. J Thorac Cardiovasc Surg.

2021 Jun;161(6):2155-2156. doi: 10.1016/j.jtcvs.2020.09.091. Epub 2020 Sep 28.

PMID: 33097212.

Burkhart, H.M., Anderson, H.N. (2021). Commentary: Pulmonary vein stenosis. Not just a surgical solution (6th ed., vol. 161, pp. 2177-2178). Journal of Thoracic and Cardiovascular Surgery. DOI: 10.1016/j.jtcvs.2020.06.066 Burkhart, H.M., Phillips, S.D. (2021). Commentary: Pulmonary valve bioprosthesis: Longevity and reintervention. (2nd ed., vol. 161, pp. 364-365). The Journal of thoracic and cardiovascular surgery.

PMID: 32859415. DOI: 10.1016/jtcvs.2020.08.003 Burkhart, H.M., Henry, E.D., Schwartz, R.M. (2021).

Commentary: Fontan Conversion: The Good News and the Bad News. Seminars in Thoracic and Cardiovascular Surgery. DOI: 10.1053/j.semtcvs.2021.03.023

Yuki Nakamura, MD Burkhart HM, Nakamura Y, Mir A. Commentary: Arterial switch operation: It's the little things that count.

JTCVS Tech. 2021 Sep 28;10:446-447. doi: 10.1016/j.xjtc.2021.09.042. PMID: 34977779; PMCID: PMC8691824.

Burkhart HM, Mir A, Nakamura Y. Commentary: Congenital aortic arch reconstruction: Keeping the window open. JTCVS Tech. 2021 Jun 15;8:132-134. doi: 10.1016/j.xjtc.2021.06.006. PMID: 34401833; PMCID: PMC8350942.

Burkhart HM, Nakamura Y, Behere SP. Commentary: Refining the reimplantation technique for anomalous aortic origin of a coronary artery. JTCVS Tech. 2021 Feb 20;7:231-232. doi: 10.1016/j.xjtc.2021.02.020.

PMID: 34318257; PMCID: PMC8311705.

Nakamura Y, Ayoubi AA, Ricci M. Outcomes of aortic valve repair with ventricular septal defect closure: An elusive task. J Card Surg. 2021 Nov;36(11):4167-4168. doi: 10.1111/jocs.15937. Epub 2021 Aug 23. PMID: 34426997.

Division of General Surgery, Trauma Surgery, Critical Care

Roxie Albrecht, MD Professor and Division Chief Vice-Chair of Quality Improvement Trauma Medical Director

Clinical Faculty Trauma | Critical Care Roxie Albrecht, MD Celia Blair, MD Scott Blair, DO Amanda Celii, MD Alisa Cross, MD Ryan Kennedy, MD Jason Lees, MD Frank Wood, MD

Burn Surgery Mary Margaret Brandt, MD

General Surgery Laura Fischer, MD Fernando Mier, MD Alexander Raines, MD

DIVISION BY THE NUMBERS January 1, 2021 - December 31, 2021

**Decreased numbers attributed to COVID-19 and its impact on healthcare globally

OR Cases

wRVUs

General Surgery 1,508

Trauma/Critical Care Surgery 17,828

General Surgery 17,387.32

Trauma/Critical Care Surgery 56,938.92

Clinical Visits General Surgery 5,513

Trauma/Critical Care Surgery 2,990

New Hires Shannon Myers, Administrative Assistant Megan Cuoco, PA-C Marielle Ysabel Del Rosario, PA-C Kenzee Gambrell, PA-C Racheal Thies, APRN

Patents Jason Lees, MD Patent Award Animal Wound Model and Methods of Use

Stories/Media Roxie M. Albrecht, MD Trauma Care during the Pandemic https://kfor.com/news/local/oklahoma-trauma-centerstaff-at-ou-health-speak-about-what-its-like-duringcovid-19-pandemic/ Laura Fischer, MD “Reconnecting in Oklahoma/Arkansas – State Chapter of the American Society for Metabolic and Bariatric Surgery (ASMBS).” ASMBS State Chapter Spotlight. Bariatric Times. 2021;18(8):16. Access online: https://bariatrictimes.com/oklahoma-arkansasstate-chapter-august/?contact_eid=8880dd2c-bc6145d5-8736-b06ec993b8cb.

Ryan Kennedy, MD Lesser-known ECMO treatment helps most critical COVID-19 patients in Oklahoma https://www.koco.com/article/ecmo-treatmentcritical-covid-19-patients-oklahoma/37704970 Alexander Raines, MD OETA - Oklahoma Educational Television Authority, Artificial Intelligence in Education, Robotic Surgery Simulation Education, https://www.oeta.tv/shows/oklahoma-news-report/, March 10, 2021

Awards & Recognition Roxie M. Albrecht, MD Elected as Vice President of the American Association for the Surgery of Trauma Elected as President-Elect Southwestern Surgical Congress Starting January 2022- CME Editor for the Journal of Trauma and Acute Care Surgery Maggie Brandt, MD Promoted to Professor Selected as member of Publications Committee of the Midwest Surgical Association for 3-year term Selected as member of Audit Committee of the Central Surgical Association Selected as member of Organization and Delivery of Burn Care Committee of the American Burn Association Amanda Celii, MD Leader for ED Throughput - Emergency Department Patient Access and Throughput Committee member Patient Progression Committee member ED Lead, Patient Progression Workgroup Direct Access Alisa Cross, MD Academy of Teaching Scholars 2021 Education Hero - OKC Simulation Center Laura Fischer, MD Chair of the Education Committee for the American College of Surgeon's Operation Giving Back collaborative surgery program in Lusaka, Zambia Editorial Board member for the journal SOARD (Surgery for Obesity and Related Diseases) Bariatric Surgery Training Sub-Committee-Credentialing Guidelines Task Force, ASMBS Ryan Kennedy, MD Faculty Leadership Program Jason Lees, MD Academy of Teaching Scholars Chair Leadership Development Institute Planning Committee Alexander Raines, MD Elected as President of Oklahoma Chapter of American College of Surgeons Dewayne Andrews, MD Excellence in Teaching Award Named Surgeon-in-Chief OU Health-Edmond Medical Center 2021 Aesculapian Award Nomination - 2022 Aesculapian Award for Excellence in Teaching Clinical Sciences - Clinical Faculty Chevonne "Chevy" Talley, APRN-CNP 2021 Staff Award - Outstanding Trauma Services Member

Grants Maggie Brandt, MD Supporting Investigator Sponsored by National Institutes of Health, Federal September 1, 2021 - August 31, 2026 Grant/Contract Number: GRF00004860 Current Funding: $2,330,987.00 Total Direct Costs: $714,627.00 Laura Fischer, MD Co-Principle Investigator(s) Harold Hamm Diabetes Center/Stephenson Cancer Center Pre-Team Science Grant 2021 – 2022 'Bariatric Surgery Among Women with Obesity and Low Risk Endometrial Cancer: A Pilot Study' $25,000 Faculty mentor Awardee: Cooper Little, MS2 SAGES Research and Career Development Committee 2021 Medical Student Summer Research Award 2021 – 2022 'Prevalence and risk factors for secondary hyperparathyroidism (SHPT) in patients undergoing bariatric surgery' $2,000 Alexander Raines, MD Principle Investigator Academy of Teaching Scholars Educational Grant 2021 - Present 'Heart rate variability as a measure of stress and EEG-directed meditative practices in medical students participating in a stress management training program' $5000 Jason Lees, MD Collaborator Sponsored by Maximizing Investigators' Research Award (MIRA) for early-stage Investigators (R-35 Clinical Trial Optional), Foundation May 25, 2021- Present Grant/Contract Number: 1R335GM142786-01 Funding: $250,000 Total Direct Costs: $1,250,000.00

Presentations Maggie Brandt, MD Emergency Medicine Grand Rounds Norman Regional Medical Center “Initial Management of Burn Injuries” May 2021 "Improving Packed Red Blood Cells Through a Novel High Viscosity Storage Solution", Central Surgical Association and Midwest Surgical Association, Chicago, IL. July 25, 2021.

"Increased Infection Control Protocols Implemented During the Covid-19 Pandemic Do Not Reduce Hospital Acquired Infections at a Tertiary Care Center", Central Surgical Association/Midwest Surgical Association Combined Meeting, Chicago, IL. July 27, 2021.

Amanda Celii, MD "Rural Trauma Outreach-Improving Trauma Care from the Start", TCAA Annual Meeting, Poster, May 4, 2021.

Anesthesia Grand Rounds Whole Blood Program, August 2021.

TRAUMA TRANSFERS DISCHARGED FROM THE EMERGENCY DEPARTMENT- IS THERE A ROLE FOR TELEMEDICINE? 80th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery, Atlanta, GA. October 2021 Which Mesh in Infection? Panel Session I: Management of an Infected Ventral Hernia. Annual meeting of Oklahoma Chapter ACS: December 3, 2021 Alisa Cross, MD "Speaking the Trauma Language", Society of Interventional Radiology, Lecture. March 24, 2021.

Clinical Diagnosis of Cholecystitis in Emergency Department patients with cholelithiasis is an indication for cholecystectomy. A comparison of clinical, ultrasound and pathologic diagnosis.

Intravenous ketorolac in a Level I trauma population: is it safe to use? 2021 Annual Meeting, Southwestern Surgical Congress, Maui, HI. Quick Shot presentation.

September 2021.

Laura Fischer, MD "Cardiovascular Benefits of Bariatric Surgery", Department of Medicine Cardiovascular Grand Rounds, University of Oklahoma Health Sciences Center, Oklahoma City, OK, Lecture, January 28, 2021.

Pro-Con Debate Con: Telehealth is Inferior to In-person Visits. ASMBS 2021 Annual Meeting. Virtual due to COVID. June 11, 2021

Presentations

Publications

Laura Fischer, MD cont'd Laparoscopic revision of Roux-en-Y gastric bypass to sleeve gastrectomy for permanent hypoparathyroidism.

ASMBS 2021 Annual Meeting. Virtual due to COVID, June 12, 2021 GLAP Manual for MIS education around the globe.

SAGES 2021 Annual Meeting. Las Vegas, NV. September 2, 2021 Laparoscopic pancreaticoduodenectomy with replaced common hepatic artery. SAGES Annual Meeting August 31, 2021 Association of Women Surgeons. Journey of Confidence: A Panel Discussion on Becoming a Female Surgeon. September 22, 2021. Virtual

Roxie Albrecht, MD Stewart K, Garwe T, Oluborode B, Sarwar Z, Albrecht RM. Association of Interfacility Helicopter versus Ground Ambulance Transport and in-Hospital Mortality among Trauma Patients. Prehosp Emerg Care. 2021 Sep-Oct;25(5):620-628. doi: 10.1080/10903127.2020.1817215. Epub 2020 Oct 5.

PMID: 32870724 Gonzalez, R.A., Robbins, J.M., Garwe, T., Stewart, K.E., Sarwar, Z., Cross, A.M., Celii, A., Albrecht, R. (2021).

Effect of Post-splenectomy Booster Vaccine Program on Vaccination Compliance in Trauma Patients. The American surgeon, 3134820956274. PMIDL 33231491. DOI: 10.1177/0003134820956274

Ryan Kennedy, MD "Pharmacologic Resuscitation of Hemorrhagic Shock", Trauma Grand Rounds, Lecture, September 2021 "Pharmacologic Resuscitation of Hemorrhagic Shock", Anesthesia Grand Rounds, Lecture, October 2021

Amanda Celii,MD Wandling, M., Cuschieri, J., Kozaar, R., O'M, L., Celii, A., Starr, W., Burlew, D.D., Todd, S.R., Leon, A.D., MeIntyre, R.C., Urban, S., Biffl, W.L., Bayat, D., Dunn, J., Peck, K., Rooney, A.S., Kornblith, L., Callcut, R.A., Lollar, D.I., Ambroz, E., Leichtle, S.W., Aboutanos, M.B., Schroeppel, T., Hennessy, E.A., Russo, R., McNutt, M. (2021). Multi-center validation of the Bowel Injury Predictive Score (BIPS) for the early identification of need to operate in blunt bowel and mesenteric injuries. Injury, July 2021 PMID: 34380598 DOI: 10.1016/j.injury.2021.07.026 Gonzalez, R.A., Robbins, J.M., Garwe, T., Stewart, K.E., Sarwar, Z., Cross, A.M., Celii, A., Albrecht, R. (2021).

Effect of Post-splenectomy Booster Vaccine Program on Vaccination Compliance in Trauma Patients. The American surgeon, 3134820956274. PMIDL 33231491. DOI: 10.1177/0003134820956274 Tracy BM, Paterson CW, Torres DM, Young K, Hochman BR, Zielinski MD, Burruss SK, Mulder MB, Yeh DD, Gelbard RB; EAST Retained Common Bile Duct Stones Study Group. Risk factors for complications after cholecystectomy for common bile duct stones: An EAST multicenter study. Surgery. 2020 Jul;168(1):62-66. doi: 10.1016/j.surg.2020.04.011.

Epub 2020 May 26.PMID: 32466829

Jason Lees, MD "Evaluation of Surgical Procedure Difficulty and Level of Supervised Independence of PGY 4 & 5 Surgical Residents", 2021 APDS Annual Meeting, Boston, MA, March 27, 2021 "Effect of Inter-Professional Perioperative Simulation on Team Communication and Airway Fire Management", Interdisciplinary Collaboration Symposium, University of Oklahoma Health Sciences Center, Oklahoma City, OK, April 9, 2021.

Alexander Raines, MD “Cognitive fitness – Emotional intelligence training in the MS3 Surgery Clerkship.” Poster presentation.

Association for Surgical Education Annual Meeting, April 2021, virtual Should we use ejection fraction in surgical evaluation of biliary dyskinesia? 2021 Annual Meeting, Southwestern Surgical Congress, Maui, HI. Quick Shot presentation. September 2021

Publications

Publications

Alisa Cross, MD McGaha, P., Klingensmith, M., Cross, A.M., Stewart, K.Grimes, A., Horton, M., Kowdley, G., Patel, Galante, J.P., Delman, K., Joshi, A. (2021). Trainee Utilization of the SCORE Curriculum is Associated with Improved ABSITE Performance: A Multi-institutional Study.

Journal of Surgical Education. DOI: https://doi.org/10.1016/j.jsurg.2021.06.022 Gonzalez, R.A., Robbins, J.M., Garwe, T., Stewart, K.E., Sarwar, Z., Cross, A.M., Celii, A., Albrecht, R. (2021). Effect of Post-splenectomy Booster Vaccine Program on Vaccination Compliance in Trauma Patients. The American surgeon, 3134820956274.

PMIDL 33231491. DOI: 10.1177/0003134820956274

Ryan Kennedy, MD American Association for the Surgery of Trauma/American College of Surgeons-Committee on Trauma Clinical Protocol for Inpatient Venous Thromboembolism Prophylaxis after Trauma. Journal of Trauma and Acute Care Surgery.

Grimes, A.D., Kennedy, R., Blair, S.G., (2021). The Management of Acute Respiratory Distess Syndrome after Near Drowning and Low-Voltage Electrocution. The American Surgeon. DOI: https://doi.org/10/1177%2F0003134820983189

Laura Fischer, MD Worrest T, Dewey E, Fischer LE. Response regarding: Missing Accessory Splenectomy as a Preventable Cause of Immune Thrombocytopenic Purpura Relapse. J Surg Res. 2021 Feb;258:463-464. doi: 10.1016/j.jss.2020.10.001. Epub 2020 Nov 5. PMID: 33160634 Rozich NS, Lewis S, Chen SX, Stewart KE, Dooley WC, Fischer LE, Morris KT. Women survive longer than men undergoing cytoreductive surgery and HIPEC for appendiceal cancer. PLOS. 2021 April;16(4):e0250726. [PMID 33930051] Grimes AD, Stewart K, Dunn G, Booth K, Carter S, Garwe T, Sarwar Z, Fischer LE. The effect of body mass index (BMI) on the creation of an end-colostomy in rectal cancer patients. Am Surg. 2021. Oct 11;31348211047474. Online ahead of print. [PMID 34633227] Fischer LE, Wolfe BM, Fino N, Elman MR, Flum DR, Mitchell JE, Pomp A, Pories WJ, Purnell JQ, Patti ME, and the LABS investigators. Post-bariatric hypoglycemia: Symptom patterns and associated risk factors in the Longitudinal Assessment of Bariatric Surgery (LABS) study. Surg Obes Relat Dis. 2021 Oct;17(10):1787-98. [PMID 34294589] Vosburg RW, Pratt JSA, Kindel T, Rogers AM, Kudav S, Banerjee A, Hernandez E, Athansiadis D, Fischer LE, Hayes K, Shin T, Aminian A, Kim JJ. Bariatric surgery is safe for patients after recovery from COVID-19. Surg Obes Relat Dis. 2021 Nov;17(11):1884-9. [PMID 34446386] Talledo, L.G., Watkins, K.M., Wagner, J.M., Fischer, L.E. (2021). Indirect Inguinal Hernia. Fundamental of Hernia Radiology. Springer.

Parmar C, Zakeri R, Aboulezayem M, Shin TH, Aminian A, Mahmoud T, Abu Dayyeh B, Wee MY, Fischer LE, Daams F, Mahawar K. Oesophageal and gastric malignancies after bariatric surgery: a retrospective global study. Surg Obes Relat Dis. Accepted for publication Dec 2, 2021

Jason Lees, MD Biffl, W.L., Ball, C.G., Moore, E.E., Lees, J., Todd, S.R., WYdo, S., Privette, A., Weaver, J.L., Koenig, S.M., Meagher, A., Dultz, L., Udekwu, P.O., Harrell, K., CHen, A.K., Callcut, R., Kornblith, L., Castelo, M., Shaffer, K.B. (2021). Don't Mess with the Pancreas! A Multicenter Analysis of the Management of Low-Grade Pancreatic Injuries. The Journal of Trauma and Acute Care Surgery. PMID: 34039927. DOI: 10.1097/TA.0000000000003293 Lees, J., Landmann, A. (2021). Resident Morale: Challenges Faced by Residents. Promoting Resiliency and Wellness Among Physician Residents (First ed., pp. 714). San Diego, CA: Cognella Academic Publishing Jalla, A., Sturges, J., Lees, J. (2021). Integration of Educational Technology. Education and the General Surgeon (4th ed., vol. 101, pp. 693-702). Elsevier.

Alexander Raines, MD Raines, A.R., "Plan B: How to process failure", College of Medicine, Oklahoma City, OK, Lecture, March 2021 Lindsey, L.. Ginter, K., Medina, J., Hickerson, S., Johnson, J., Clark, J., Bouvette, M., Raines, A.R., "Cognitive fitness - Emotional intelligence training in the MS3 Surgery Clerkship", Annual Meeting, Association for Surgical Education, Online, Poster. April 2021 Barmparas G, Alhaj Saleh A, Huang R, Eaton BC, Bruns BR, Raines A, Bryant C, Crane CE, Scherer EP, Schroeppel TJ, Moskowitz E, Regner JL, Frazee R, Campion EM, Bartley M, Mortus JR, Ward J, Margulies DR, Dissanaike S. Empiric antifungals do not decrease the risk for organ space infection in patients with perforated peptic ulcer. Trauma Surg Acute Care Open.

2021 May 19;6(1):e000662. doi: 10.1136/tsaco-2020000662. E Collection 2021. PMID: 34079912 Lade C, Lewis S, Venincasa K, Harmon A, Choi P, Lee B, Raines A. Feasibility of robotic-assisted minimally invasive inguinal hernia repair in patients with urologic considerations including artificial urinary sphincters and bladder herniation. J Robot Surg. 2021 Oct;15(5):695699. doi: 10.1007/s11701-020-01163-7. Epub 2020 Oct 26. PMID: 33107011

Division of Pediatric Surgery

Catherine J. Hunter, MD Associate Professor and Division Chief Paula Milburn Miller Chair in Pediatric Surgery

DIVISION BY THE NUMBERS

Clinical Faculty

January 1, 2021 - December 31, 2021

Catherine Hunter, MD Jeremy Johnson, MD

**Decreased numbers attributed to COVID-19 and its impact on healthcare globally

Alessandra Landmann, MD Cameron Mantor, MD

OR Cases

Nikola Puffinbarger, MD

Pediatric Surgery 2,691

Alex Ruiz, MD

wRVUs Pediatric Surgery 18,562.61

Fellowship Coordinator Brookelynne Davidson Residency Program Coordinator

Clinical Visits Pediatric Surgery 2,275

New Hires Leisel D. Gowens, Administrative Assistant Alena A. Golubkova, MD, Postdoctoral Research Fellow

Awards & Recognition Alena Golubkova, MD Certificate of Recognition - Academy of Teaching Scholars 2021 Health Professions Education Research Poster Session Catherine Hunter, MD Promoted to Associate Professor with Tenure Division Chief of Pediatric Surgery President's Citation for Exemplary Service, Surgical Infection Society Physician Leader-Children's Oncology Group Member-Department of Clinical and Translational Sciences Graduate Faculty Member-The Children's Hospital Neonatal Consortium Necrotizing Entercolitis (NEC) focus group Member-American Academy of Pediatrics (AAP), section of Surgery Nominating Committee Jeremy Johnson, MD Dewayne Andrews, MD Excellence in Teaching Award 2021 Academy of Teaching Scholars Hero Award

Alessandra Landmann, MD

Grants Catherine Hunter, MD Principle Investigator OSCTR Grant Pilot Project, Federal January 1, 2021 - Present "Defing the role of ROCK and caveolin-1 in necrotizing enterocolitis" Current Funding: $50,000.00 Principle Investigator Oklahoma Center for Adult Stem Cell Research January 1, 2021 - Present "Defining the role of the intestinal barrier in necrotizing enterocolitis using human enteroids" Total Direct Costs: $120,000.00

Stories/Media Catherine Hunter, MD "Interesting Cases from the Frontlines of COVID-19". Host, Surgical Infection Society, February 4, 2021 https://www.sisna.org/webinars-podcasts/webinardetail/interesting-cases-from-frontlines-of-covid-19 "Restoration of Services after Covid-19". Expert Interview, Surgical Infection Society, April 15, 2021. Zoom webinar.

Heather Liebe, MD Certificate of Recognition - Academy of Teaching Scholars 2021 Health Professions Education Research Poster Session 2021 Surgery Pilot Grant Award Recipient Cameron Mantor, MD Acting Chief Medical Officer for OU Health 25+ Years of Service Recognition Nikola Puffinbarger, MD 20 Years of Service Recognition

Presentations Catherine Hunter, MD Hunter, C. J., Upperman, J., Barie, P., Mendoza, A., "Interesting Cases from the Frontlines of COVID-19", Surgical Infection Society Webinar, Surgical Infection Society, Virtual (Live), Invited, Panel. February 4, 2021.

Hunter, C. J., Schubl, S., Ho, V., Narayan, M., "Restoration of Services After COVID-19", Surgical Infection Society Webinar, Surgical Infection Society, Webinar, Invited, Panel. April 15, 2021.

Hunter, C. J., "Necrotizing Enterocolitis: Models and Tight Junctions", Neonatal Grand Rounds, Nationwide Children's Hospital, Columbus, OH, Invited, Keynote/Plenary Address. August 25, 2021.

Leiva, T.*, Wood, D.*, Hunter, C. J., "Caveolin-1 Expression in Human Neonatal Tissue with Necrotizing Enterocolitis", Department of Surgery Research Day, The University of Oklahoma, Oklahoma City, OK, Oral Presentation.

October 2021.

Presentations Catherine Hunter, MD cont'd Golubkova, A.*, Liebe, H.*, Papin, J., Friedman, J., Myers, D., Hunter, C. J., "Effect of Maternal Diet on Inflammation and Gut Barrier Integrity in Baboon Offspring", Department of Surgery Research Day, The University of Oklahoma, Oklahoma City, OK, Oral Presentation. October 2021.

Liebe, H.*, Schlegel, C.*, Hunter, C. J., "ROCK1 Inhibition Strengthens Barrier Function in a Human Enteroid Model of Neonatal Intestine", Department of Surgery Research Day, The University of Oklahoma, Oklahoma City, OK, Oral Presentation. October 2021.

Hunter, C. J., "Navigating Difficult Ethical Decisions in Pedaitric Surgery", The 33rd Annual Dorothy J. MacLean Conference on Clinical Medical Ethics, University of Chicago, Virtual/ Chicago, IL, Invited, Lecture. November 13, 2021.

Jeremy Johnson, MD Lewis, S., Liebe, H., Jeffrey, C., Sebastian, R., Stewart, Sarwar, Z., Johnson, J. J., "Pediatric trauma mortalities in Oklahoma: Are they preventable?", Annual Meeting, Academic Surgical Congress, Virtual, Oral Presentation. February 2, 2021.

Publications Catherine Hunter, MD Liebe, H.*, Hunter, C. J.# (2021). Ethical considerations of academic surgical research. Seminars in Pediatric Surgery, 30(5). DOI: https://doi.org/10.1016/j.sempedsurg.2021.151097 Liebe, H.*+, Buonpane, C.*, Lewis, S.*, Golubkova, A.*, Leiva, T.*, Phillips, R., Hunter, C. J.# (2021). This is Our Lane: A Pilot Study Examining the SUrgeon's Role in Social Justice Advocacy.

The American Journal of Surgery. PMID: 34588129.

Pennington, E.+, Hunter, C. J.# (2021). Ethical Dilemmas in the Management of Infants with Necrotizing Enterocolitis Totalis.

Journal of Pediatric Surgery. DOI: https://doi.org/10.1016/j.jpedsurg.2021.08.026 Hunter, C. J., Gosain, A.# (2021). Significance and innovation: cornerstones of a successful grant application. Surgery. PMID: 33902925.

Barie, P.#, Ho, V., Hunter, C. J., Kaufman, E. J., Narayan, M., Pieracci, F., Schubl, S. D., Heffernan, D. S., Huston, J. (2021).

Surgical Infection Society Guidance for Restoration of Surgical Services during the Coronavirus Disease-2019 Pandemic. Surgical Infections. PMID: 33635145. DOI: 10.1089/sur.2020.421 Bury, M., Fuller, N., Clemons, T., Sturm, R., Morrison, C., LisySnow, D., Nolan, B., Tarczynski, C., Ayello, E., Boyce, A., Muckian, B., Ahmad, N., Hunter, C. J., Karver, M., Stupp, S., Sharma, A.# (2021). Self-Assembling Nanofibers Inhibit Inflammation in a Murine Model of Crohn's Disease-Like Ileitis. Advanced Therapeutics. DOI: https://doi.org/10.1002/adtp.202000274

Publications Catherine Hunter, MD cont'd Lewis, S.*, Urdaneta Perez, M. G.*#, Hunter, C. J., Carlisle, E.# (in press). A Careful Balance of the Benefits and Burdens of Pediatric ECMO. Difficult Decisions in Surgical Ethics: An Evidence-Based Approach. Springer Nature.

Buonpane CL, Vacek J, Harris CJ, Salazar Osuna JH, Van Arendonk KJ, Hunter CJ, Goldstein SD. Controversy in the classification of appendicitis and utilization of postoperative antibiotics. Surgery. 2021 Nov 10:S0039-6060(21)00964-8. doi: 10.1016/j.surg.2021.10.006. Epub ahead of print.

PMID: 34774292.

Buonpane C, Ares G, Yuan C, Schlegel C, Liebe H, Hunter CJ. Experimental Modeling of Necrotizing Enterocolitis in Human Infant Intestinal Enteroids. J Invest Surg. 2022 Jan;35(1):111-118. doi: 10.1080/08941939.2020.1829755.

Epub 2020 Oct 26. PMID: 33100066.

Jeremy Johnson, MD Notrica, D. M., Sussman, B. L., Sayrs, L. W., St Peter, S. D., Maxson, R. T., Alder, A. C., Eubanks, 3rd, J. W., Johnson, J. J., Ostlie, D. J., Ponsky, T., Naiditch, J. A., Leys, C. M., Lawson, K. A., Greenwell, C., Bhatia, A., Garcia, N. M. (2021). Early vasopressor administration in pediatric blunt liver and spleen injury: An ATOMAC+ study. Journal of pediatric surgery, 56(3), 500-505. PMID: 32778447.

DOI: 10.1016/j.jpedsurg.2020.07.007 Lewis, S., Johnson, J. J., Bergner, E. M., Miller, J. L., Bruster, C. '., Atchley, C. B., Ernst, K. D. (2021). Infant Essential Fatty Acid Status Is Not Associated With Postoperative Wound Complication Severity. The Journal of surgical research, 258, 435-442. PMID: 33317758. DOI: 10.1016/j.jss.2020.08.046 McGaha, P., Stewart, K., Garwe, T., Johnson, J. J., Sarwar, Z., Letton, R. W. (2021). Is it time for firearm injury to be a separate activation criteria in children? An assessment of penetrating pediatric trauma using need for surgeon presence. American journal of surgery. PMID: 32546370.

DOI: 10.1016/j.amjsurg.2020.06.003 Lewis SL, Grimes AD, Stewart KE, Landman A, Sarwar Z, Johnson JJ, Kennedy R. Retrospective review of intervention for traumatic blunt spleen injuries in adolescents by trauma center type. Am J Surg. 2021 Dec 15:S0002-9610(21)00736-4. doi: 10.1016/j.amjsurg.2021.12.010. Epub ahead of print.

PMID: 34953577.

Alessandra Landmann, MD Landmann, A., Bonds, M. M.+, Postier, R.# (2021).

Chapter 47: Acute Abdomen. In Townsend, C., Beauchamp, D., Evers, K., Mattox, K. (Eds.), Sabiston Textbook of Surgery (vol. 21). Elsevier.

Division of Plastic & Reconstructive Surgery

Suhair Maqusi, MD Associate Professor & Division Chief Plastic Surgery Fellowship Program Director

DIVISION BY THE NUMBERS

Clinical Faculty Guilherme Barreiro, MD

January 1, 2021 - December 31, 2021

**Decreased numbers attributed to COVID-19 and its impact on healthcare globally

Christian El Amm, MD Suhair Maqusi, MD

OR Cases

Mark Mims, MD

Fellowship Coordinator

Plastic Surgery 1,711

wRVUs

Magali Ochoa

Plastic Surgery 32,661.65

Residency Program Coordinator

Clinical Visits Plastic Surgery 4,889

New Hires Saeko 'Koko' Lord, Administrative Assistant

Awards & Recognition Guilherme Barreiro, MD Associate Member, Academy of Teaching Scholars Christian El Amm, MD 2021 Castle Connolly - Top Doctor 2021 Oklahoman Top Doctors 15 Years of Service Recognition Suhair Maqusi, MD Associate Member, Academy of Teaching Scholars

Patents Christian El Amm, MD Co-Discoverer: Dr. Mohammad Abdul Mukit Invention Disclosure No. 2022-030 "Interoperative Virtual Surgical Planning Through Medical Mixed Reality"

Presentations Guilherme Barreiro, MD University of Oklahoma Health Sciences Center Department of Surgery Grand Rounds.

"Reconstructive Techniques". November 12, 2021.

Publications Chrisitan El Amm, MD Tufaro, A. P.+, El Amm, C. A.+ (2021). Plastic Surgery. Mulholland and Greenfield's 7th Ed Surgery Scientific Principles and Practice. Wolters Kluwer Amm E, El Amm C, Vaden J. Effect of Class II elastics on different mandibular arch preparation stabilized with aligners and stainless-stseel wires: a FEM study.

Orthod Craniofac Res. 2022 Jan 11. doi: 10.1111/ocr.12564. Epub ahead of print. PMID: 35015923.

Mark Mims, MD Ghodke A, Mims MM, Meyer M, Clark JM, Shockley WW. Aesthetic Helical Reconstruction: Postauricular Flap with Primary Skin Graft. Facial Plast Surg Aesthet Med. 2021 Nov 29. doi: 10.1089/fpsam.2021.0275. Epub ahead of print.

PMID: 34847722.

Ghodke A, Mims MM, Shah RN, Clark JM. A Complication of Mycobacterium chelonae Infection Following Orbital Floor Fracture Repair. J Craniofac Surg. 2021 Jun 1;32(4):1494-1495. doi: 10.1097/SCS.0000000000007423. PMID: 33427778.

Division of Surgical Oncology

Ajay Jain, MD Professor and Division Chief Core Medical Director Stephenson Cancer Center

Clinical Faculty Breast Surgery Juan Claros-Sorto, MD Willliam Dooley, MD Teresa Shavney, MD Ronald Squires, MD

DIVISION BY THE NUMBERS January 1, 2021 - December 31, 2021

**Decreased numbers attributed to COVID-19 and its impact on healthcare globally

OR Cases Colorectal Surgery Kristina Booth, MD Steven Carter, MD Gary D. Dunn, MD

Hepato-Pancreato-Biliary Surgery Morgan Bonds, MD Barish Edil, MD Ajay Jain, MD Katherine Morris, MD

Breast Surgery 666

Hepatobiliary 478

Colorectal Surgery 2,297

Hepatobiliary 4,974.34

Colorectal Surgery 13,652.69

Hepatobiliary 842

Colorectal Surgery 2,351

wRVUs Breast Surgery 8,521.95

Clinical Visits Breast Surgery 2,146

New Hires Nicole Warren, Administrative Supervisor / Finance Coordinator Jayde Leon, Administrative Assistant Shawna McDaniel, Administrative Assistant

Awards & Recognition Kristina Booth, MD Academy of Teaching Scholars member Academy of Teaching Scholars Recognition and Award Committee member OU Department of Surgery CME Planning Committee SIMPL CMBE Engagement Committee member Morgan Bonds, MD Assistant Professor Junior Surgeon Committee AHPBA member 2021 Surgery Pilot Grant Award Recipient Juan Carlos Claros-Sorto, MD Academy of Teaching Scholars 2021 Education Hero Health Care Hero nomination William Dooley, MD 20 Years of Service Recognition Barish Edil, MD 2021 - 405 Magazine Top Docs Chief Operating Office Adult Division OU Health Surgeon in Chief OU Health Chair, SSAT Member Services Committee, Society for Surgery of the Alimentary Tract Associate Member Stephenson Cancer Center Therapeutics Research Program Faculty Board College of Medicine member Chair, OU Health General Surgery Core Group Ajay Jain, MD Inducted Associate Member of the American College of Surgeons Academy of Master Surgeon Educators Appointed Oklahoma State Chair for American College of Surgeons on Cancer Appointed Professor with Tenure Katherine Morris, MD Promoted to Professor of Surgery with Academic Tenure Western Surgical Association Investments Committee member Society of University Surgeons membership committee

Stories/Media Krisina Booth, MD A Deep Discussion of Our Personal Ecosystem with Kristina Booth. Guest Speaker, The Verdict. March 17, 2021 https://www.youtube.com/watch? v=am9Ds7GKekQ "Colon Cancer Signs to Watch for Now, Say Doctors". Expert Interview, Eat This, Not That!

March 29, 2021 https://www.eatthis.com/newssigns-colon-cancer/ Ostomy 101: Insight from a Surgeon. Expert Interview, Gastro Girl. August 10, 2021 https://x.facebook.com/GASTROGIRLINC/videos/ne w-episodemolly-olly-ostomy-gave-us-the-patientperspective-on-living-with-ano/370969757868266/? m_entstream_source=timeline&_se_imp=0Qhs9A0 X9jhJ7gGRE

Grants Ajay Jain, MD Stephenson Cancer Center Cancer Therapeutics Pilot Grant Identification of microRNAs in cachexia in African Americans with pancreatic carcinoma Katherine Morris, MD Presbyterian Health Foundation (PHF) Bridge Grant Program CSF3 is a Novel Therapeutic Target that Suppresses Antitumor T Cells in Colorectal Cancer Current Funding: $75,000.00 October 1, 2020 - September 30, 2021

Presentations Morgan Bonds, MD Association of Women Surgeons. Journey of Confidence: A Panel Discussion on Becoming a Female Surgeon. September 22, 2021. Virtual Kristina Booth, MD 2021 APDS Annual Meeting, Oral presentation: "Evaluation of Surgical Procedure Difficulty and Level of Supervised Independence of PGY 4&5 Surgical Residents." March 27, 2021.

Guest Speaker - Junior League of Oklahoma City.

April 13, 2021

Presentations

Publications

Kristina Booth, MD cont'd Academy of Teaching Scholars, University of Oklahoma. Poster Session, ATS Education week.

"Correlation of Supervised Independence and Performance with Procedure Difficulty Amongst Surgical Residents Stratified by Post Graduate Year."

September 17, 2021.

Academy of Teaching Scholars, University of Oklahoma. Poster Session, ATS Education week.

"Comparing Level of Autonomy, Performance, and Procedure Difficulty Amongst Surgical Residents Stratified by Post Graduate Year Across General Surgery Residencies Nationwide." September 17, 2021.

Morgan Bonds, MD Bonds M. Invited commentary for a nationwide analysis of gallbladder surgery in England between 2000 and 2019. Surgery. 2021 Dec 13:S00396060(21)01099-0. doi: 10.1016/j.surg.2021.10.059.

Epub ahead of print. PMID: 34916073.

Bonds M, Garwe T, Rozich N, Oluborode B, Sarwar Z, Postier RG, Morris KT. Risk Factors Associated With Readmission After Pancreatectomy: A Single-Institution Retrospective Cohort Study. Am Surg. 2021 Jan 31:3134820988824. doi: 10.1177/0003134820988824. Epub ahead of print.

PMID: 33517699.

Landmann, A., Bonds, M. M.+, Postier, R.# (2021).

Chapter 47: Acute Abdomen. In Townsend, C., Beauchamp, D., Evers, K., Mattox, K. (Eds.), Sabiston Textbook of Surgery (vol. 21). Elsevier.

Barish Edil, MD American College of Surgeons Clinical Programs Webinar, "How to Put New Clinical Programs into Practice", March 17, 2021.

Visiting Professor University of Tennessee. "Surgical Advances in the Treatment of Pancreas Cancer".

University of Tennessee Health Science Center, November 10, 2021.

Ajay Jain, MD American College of Surgeons International Relations Committee Panel, Putting Clinical Programs into Practice, Moderator. March 17, 2021 University of Oklahoma Health Sciences Center Department of Surgery Grand Rounds. "The Surgical Management of Metastatic Colorectal Cancer". August 13, 2021 Katherine Morris, MD The Stephenson Cancer Center Annual Research Symposium. "Inhibition of granulocyte colony stimulating figure remodels the tumor immune microenvironment and may enhance efficacy of currently available immune checkpoint blockade in colorectal cancer." Oral presentation. January 5, 2021 OU Health Cancer Workshop. "Colorectal Cancer Workshop". March 30, 2021.

University of Oklahoma Health Sciences Center Department of Surgery Grand Rounds. "The Surgeon as a Translational Scientist". September 17, 2021 Ronald Squires, MD NATCO 46th Annual Meeting. Poster Presentation: Get Pumped: A single OPO pilot study examining verapamil in hypothermic machine perfused kidneys.

August 3-6, 2021.

AOPO Conference. Oral presentation: Customized OPO Kidney Change Packet Results in Improved Utilization. June 29-July 1, 2021.

Kristina Booth, MD Jones MA, MacCuaig WM, Frickenstein AN, Camalan S, Gurcan MN, Holter-Chakrabarty J, Morris KT, McNally MW, Booth KK, Carter S, Grizzle WE, McNally LR. Molecular Imaging of Inflammatory Disease.

Biomedicines. 2021 Feb 4;9(2):152. doi: 10.3390/biomedicines9020152. PMID: 33557374; PMCID: PMC7914540.

Grimes AD, Stewart KE, Morris KT, Dunn GD, Booth KK, Carter SN, Garwe T, Sarwar Z, Fischer LE. The Effect of Body Mass Index on the Creation of an EndColostomy in Rectal Cancer Patients. Am Surg. 2021 Oct 11:31348211047474. doi: 10.1177/00031348211047474. Epub ahead of print.

PMID: 34633227.

Steven Carter, MD Jones MA, MacCuaig WM, Frickenstein AN, Camalan S, Gurcan MN, Holter-Chakrabarty J, Morris KT, McNally MW, Booth KK, Carter S, Grizzle WE, McNally LR. Molecular Imaging of Inflammatory Disease.

Biomedicines. 2021 Feb 4;9(2):152. doi: 10.3390/biomedicines9020152. PMID: 33557374; PMCID: PMC7914540.

Grimes AD, Stewart KE, Morris KT, Dunn GD, Booth KK, Carter SN, Garwe T, Sarwar Z, Fischer LE. The Effect of Body Mass Index on the Creation of an EndColostomy in Rectal Cancer Patients. Am Surg. 2021 Oct 11:31348211047474. doi: 10.1177/00031348211047474. Epub ahead of print.

PMID: 34633227.

Publications William Dooley, MD cont'd Rozich NS, Lewis SE, Chen S, Stewart KE, Stout MB, Dooley WC, Fischer LE, Morris KT. Women survive longer than men undergoing cytoreductive surgery and HIPEC for appendiceal cancer. PLoS One. 2021 Apr 30;16(4):e0250726. doi: 10.1371/journal.pone.0250726. PMID: 33930051; PMCID: PMC8087099.

Hills N, Leslie M, Davis R, Crowell M, Kameyama H, Rui H, Chervoneva I, Dooley W, Tanaka T. Prolonged Time from Diagnosis to Breast-Conserving Surgery is Associated with Upstaging in Hormone Receptor-Positive Invasive Ductal Breast Carcinoma. Ann Surg Oncol.

2021 Oct;28(11):5895-5905. doi: 10.1245/s10434-02109747-9. Epub 2021 Mar 21. PMID: 33748899; PMCID: PMC7982278.

Hills N, Leslie M, Davis R, Crowell M, Kamemyama H, Rui H, Chervoneva I, Dooley W, Tanaka T. ASO Author Reflections: Does Prompt Breast-Conserving Surgery Matter? Ann Surg Oncol. 2021 Oct;28(11):5906. doi: 10.1245/s10434-021-09753-x. Epub 2021 Mar 5. PMID: 33666812.

Gary D. Dunn, MD Grimes AD, Stewart KE, Morris KT, Dunn GD, Booth KK, Carter SN, Garwe T, Sarwar Z, Fischer LE. The Effect of Body Mass Index on the Creation of an End-Colostomy in Rectal Cancer Patients. Am Surg. 2021 Oct 11:31348211047474. doi: 10.1177/00031348211047474. Epub ahead of print.

PMID: 34633227.

Barish Edil, MD Pan Li, Noah Rozich, Jianxin Wang, Junke Wang, Yao Xu, Brian Herbst, Raymond Yu, Stephen Muth, Nan Niu, Keyu Li, Vanessa Funes, Jessica Gai, Arsen Osipov, Barish Edil, Christopher Wolfgang, Ming Lei, Tingbo Liang, Lei Zheng; Anti-IL-8 antibody activates myeloid cells and potentiates the anti-tumor activity of antiPD-1 antibody in the humanized pancreatic cancer murine model; manuscript number: CIR-21-0897-ET; Cancer Immunology Research; research article Sun Y, Chen W, Torphy RJ, Yao S, Zhu G, Lin R, Lugano R, Miller EN, Fujiwara Y, Bian L, Zheng L, Anand S, Gao F, Zhang W, Ferrara SE, Goodspeed AE, Dimberg A, Wang XJ, Edil BH, Barnett CC, Schulick RD, Chen L, Zhu Y. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Sci Transl Med. 2021 Jul 28;13(604):eabc8922. doi: 10.1126/scitranslmed.abc8922. PMID: 34321321; PMCID: PMC8749958.

Publications Barish Edil, MD cont'd Wang M, Ding D, Qin T, Wang H, Liu Y, Liu J, Liu J, Zhang H, Zhao J, Wu CH, Javed A, Wolfgang C, Guo S, Chen Q, Zhao W, Shi W, Zhu F, Guo X, Li X, He R, Xu S, Edil B, Tien YW, Jin G, Zheng L, He J, Qin R; Minimally Invasive Pancreas Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare. New staging classification for pancreatic neuroendocrine neoplasms combining TNM stage and WHO grade classification []. Cancer Lett. 2021 Oct 10;518:207-213. doi: 10.1016/j.canlet.2021.07.018. Epub 2021 Jul 14.

PMID: 34271105.

Zheng L, Ding D, Edil BH, Judkins C, Durham JN, Thomas DL 2nd, Bever KM, Mo G, Solt SE, Hoare JA, Bhattacharya R, Zhu Q, Osipov A, Onner B, Purtell KA, Cai H, Parkinson R, Hacker-Prietz A, Herman JM, Le DT, Azad NS, De Jesus-Acosta AMC, Blair AB, Kim V, Soares KC, Manos L, Cameron JL, Makary MA, Weiss MJ, Schulick RD, He J, Wolfgang CL, Thompson ED, Anders RA, Sugar E, Jaffee EM, Laheru DA. Vaccine-Induced Intratumoral Lymphoid Aggregates Correlate with Survival Following Treatment with a Neoadjuvant and Adjuvant Vaccine in Patients with Resectable Pancreatic Adenocarcinoma. Clin Cancer Res. 2021 Mar 1;27(5):1278-1286. doi: 10.1158/10780432.CCR-20-2974. Epub 2020 Dec 4. PMID: 33277370; PMCID: PMC7925374.

Ajay Jain, MD Miller B, Chalfant H, Thomas A, Wellberg E, Henson C, McNally MW, Grizzle WE, Jain A, McNally LR. Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer.

Int J Mol Sci. 2021 Mar 9;22(5):2757. doi: 10.3390/ijms22052757. PMID: 33803201; PMCID: PMC7963150.

Frickenstein AN, Hagood JM, Britten CN, Abbott BS, McNally MW, Vopat CA, Patterson EG, MacCuaig WM, Jain A, Walters KB, McNally LR. Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect. Pharmaceutics. 2021 Apr 17;13(4):570. doi: 10.3390/pharmaceutics13040570. PMID: 33920503; PMCID: PMC8072651.

Publications

Publications

Katherine Morris, MD Jones MA, MacCuaig WM, Frickenstein AN, Camalan S, Gurcan MN, Holter-Chakrabarty J, Morris KT, McNally MW, Booth KK, Carter S, Grizzle WE, McNally LR. Molecular Imaging of Inflammatory Disease.

Biomedicines. 2021 Feb 4;9(2):152. doi: 10.3390/biomedicines9020152. PMID: 33557374; PMCID: PMC7914540.

Rozich NS, Lewis SE, Chen S, Stewart KE, Stout MB, Dooley WC, Fischer LE, Morris KT. Women survive longer than men undergoing cytoreductive surgery and HIPEC for appendiceal cancer. PLoS One. 2021 Apr 30;16(4):e0250726. doi: 10.1371/journal.pone.0250726. PMID: 33930051; PMCID: PMC8087099.

Saunders AS, Bender DE, Ray AL, WU X, Morris KT. Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. PLoS ONE, 2021 Feb; 16(2): e0247233. doi:10.1371/journal.pone.0247233.

Grimes AD, Stewart KE, Morris KT, Dunn GD, Booth KK, Carter SN, Garwe T, Sarwar Z, Fischer LE. The Effect of Body Mass Index on the Creation of an EndColostomy in Rectal Cancer Patients. Am Surg. 2021 Oct 11:31348211047474. doi: 10.1177/00031348211047474. Epub ahead of print.

PMID: 34633227.

Bonds M, Garwe T, Rozich N, Oluborode B, Sarwar Z, Postier RG, Morris KT. Risk Factors Associated With Readmission After Pancreatectomy: A Single-Institution Retrospective Cohort Study. Am Surg. 2021 Jan 31:3134820988824. doi: 10.1177/0003134820988824. Epub ahead of print.

PMID: 33517699.

Xu YF, Xu X, Bhandari K, Gin A, Rao CV, Morris KT, Hannafon BN, Ding WQ. Isolation of extra-cellular vesicles in the context of pancreatic adenocarcinomas: Addition of one stringent filtration step improves recovery of specific microRNAs. PLoS One. 2021 Nov 16;16(11):e0259563. doi: 10.1371/journal.pone.0259563. PMID: 34784377; PMCID: PMC8594802.

Panneerselvam J, Madka V, Rai R, Morris KT, Houchen CW, Chandrakesan P, Rao CV. Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism.

Cancers (Basel). 2021 Oct 14;13(20):5159. doi: 10.3390/cancers13205159. PMID: 34680308; PMCID: PMC8533859.

Ronald Squires, MD Boyer AJ, Ketcham RE, Hostetler CA, Orlowski JP, Squires RA. Performance of Renal Allografts Perfused With Verapamil-Treated Perfusion Solution.

Prog Transplant. 2021 Dec;31(4):373-380. doi: 10.1177/15269248211045999. Epub 2021 Oct 29.

PMID: 34713753.

Hudgins JJ, Boyer AJ, Orr KD, Hostetler CA, Orlowski JP, Squires RA. The Impact and Implications of The COVID-19 Pandemic on Organ Procurement Outside of an Epicenter. Prog Transplant. 2021 Jun;31(2):171173. doi: 10.1177/15269248211002808. Epub 2021 Mar 15. PMID: 33722146.

Division of Transplant Surgery

Tomasz Kozlowski, MD Professor & Division Chief

Clinical Faculty Transplant Surgeons Oya Andacoglu, MD Narendra Battula, MD Tomasz Kozlowski, MD

DIVISION BY THE NUMBERS January 1, 2021 - December 31, 2021

**Decreased numbers attributed to COVID-19 and its impact on healthcare globally

OR Cases Nephrologist Elzbieta Rybicka-Kozlowska, MD

Hepatologists Sidra Ahsan, MD Abdul Oseini, MD

Transplant Surgery 1,193

wRVUs Transplant Surgery 5,721.03

Clinical Visits Transplant Surgery 3

New Hires Monika Medwayosh, Administrative Assistant

Sidra Ahsan, MD

Oya Andacoglu, MD

Abdul Oseini, MD

Awards & Recognition Transplant surgery is the newest division to join the Department of Surgery. In 2021, the transplant team implanted the highest number of organs at OU. We had more than 70 organs transplanted for liver, kidney, and pancreas recipients. The Liver Transplant Program regained its CMS Certificate and ended 2021 with more than 40 liver transplants. The previous record for liver transplants at OU Health was 19 in one year, in 2019. Congratulations to the growing transplant team for their hard work and determination.

Publications Oya Andacoglu, MD Karadag HI, Andacoglu O, Papadakis M, Paul A, Oezcelik A, Malamutmann E. Invasive Fungal Infections After Liver Transplantation: A Retrospective Matched Controlled Risk Analysis. Ann Transplant.

2021 Aug 6;26:e930117. doi: 10.12659/AOT.930117.

PMID: 34354035; PMCID: PMC8353998.

Cheema F, Andacoglu O, Huang LC, Phillips SE, Malcher F. Risk Factors for Surgical Site Occurrence or Infection and Recurrence After Incisional Hernia Repair in Abdominal Transplant Population. Transplant Proc.

2021 Mar;53(2):762-767. doi: 10.1016/j.transproceed.2021.01.014. Epub 2021 Feb 4. PMID: 33551186.

Andacoglu O, Özbek U, Liu J, Figueredo C, Chacko KR, Tow C, Reinus JF, Kinkhabwala M. Comparison of 1Year Morbidity Following Liver Transplant for Acute Alcoholic Hepatitis Versus Alcoholic Cirrhosis. Exp Clin Transplant. 2021 May;19(5):439-444. doi: 10.6002/ect.2020.0189. Epub 2021 Jan 11. PMID: 33455569.

Yankol Y, Bugeaud E, Zens T, Rizzari M, Mecit N, Leverson GE, Foley D, Mezrich JD, Kanmaz T, Andaçoğlu OM, D'Alessandro AM, Acarlı KS, Kalayoğlu M, Fernandez LA. A comparison of rates and severity of chronic kidney disease in deceaseddonor and living-donor liver transplant recipients: times matter. Turk J Med Sci. 2021 Apr 30;51(2):610-622. doi: 10.3906/sag-2007-82. PMID: 33037873; PMCID: PMC8203160.

Elzbieta Rybicka-Kozlowska, MD Rybicka-Kozlowska E, Andreoni K, Kozlowski T. Racial differences in renal transplantation: How do we bridge the gap? Surgery. 2021 Jul;170(1):333-335. doi: 10.1016/j.surg.2021.02.030. Epub 2021 Mar 31.

PMID: 33810852.

Publications

Publications

Tomasz Kozlowski, MD Jackson KR, Long J, Motter J, Bowring MG, Chen J, Waldram MM, Orandi BJ, Montgomery RA, Stegall MD, Jordan SC, Benedetti E, Dunn TB, Ratner LE, Kapur S, Pelletier RP, Roberts JP, Melcher ML, Singh P, Sudan DL, Posner MP, El-Amm JM, Shapiro R, Cooper M, Verbesey JE, Lipkowitz GS, Rees MA, Marsh CL, Sankari BR, Gerber DA, Wellen J, Bozorgzadeh A, Gaber AO, Heher E, Weng FL, Djamali A, Helderman JH, Concepcion BP, Brayman KL, Oberholzer J, Kozlowski T, Covarrubias K, Desai N, Massie AB, Segev DL, Garonzik-Wang J. Center-level Variation in HLA-incompatible Living Donor Kidney Transplantation Outcomes. Transplantation. 2021 Feb 1;105(2):436-442. doi: 10.1097/TP.0000000000003254. PMID: 32235255; PMCID: PMC8080262.

Motter JD, Jackson KR, Long JJ, Waldram MM, Orandi BJ, Montgomery RA, Stegall MD, Jordan SC, Benedetti E, Dunn TB, Ratner LE, Kapur S, Pelletier RP, Roberts JP, Melcher ML, Singh P, Sudan DL, Posner MP, ElAmm JM, Shapiro R, Cooper M, Verbesey JE, Lipkowitz GS, Rees MA, Marsh CL, Sankari BR, Gerber DA, Wellen JR, Bozorgzadeh A, Gaber AO, Heher EC, Weng FL, Djamali A, Helderman JH, Concepcion BP, Brayman KL, Oberholzer J, Kozlowski T, Covarrubias K, Massie AB, Segev DL, Garonzik-Wang JM. Delayed graft function and acute rejection following HLAincompatible living donor kidney transplantation. Am J Transplant. 2021 Apr;21(4):1612-1621. doi: 10.1111/ajt.16471. Epub 2021 Feb 27. PMID: 33370502; PMCID: PMC8016719.

Witkowski P, Philipson LH, Kaufman DB, Ratner LE, Abouljoud MS, Bellin MD, Buse JB, Kandeel F, Stock PG, Mulligan DC, Markmann JF, Kozlowski T, Andreoni KA, Alejandro R, Baidal DA, Hardy MA, Wickrema A, Mirmira RG, Fung J, Becker YT, Josephson MA, Bachul PJ, Pyda JS, Charlton M, Millis JM, Gaglia JL, Stratta RJ, Fridell JA, Niederhaus SV, Forbes RC, Jayant K, Robertson RP, Odorico JS, Levy MF, Harland RC, Abrams PL, Olaitan OK, Kandaswamy R, Wellen JR, Japour AJ, Desai CS, Naziruddin B, Balamurugan AN, Barth RN, Ricordi C; “Islets for US” Collaborative. The demise of islet allotransplantation in the United States: A call for an urgent regulatory update. Am J Transplant. 2021 Apr;21(4):1365-1375. doi: 10.1111/ajt.16397. Epub 2021 Feb 10. PMID: 33251712; PMCID: PMC8016716.

Rybicka-Kozlowska E, Andreoni K, Kozlowski T. Racial differences in renal transplantation: How do we bridge the gap? Surgery. 2021 Jul;170(1):333-335. doi: 10.1016/j.surg.2021.02.030. Epub 2021 Mar 31.

PMID: 33810852.

Tomasz Kozlowski, MD cont'd Witkowski P, Odorico J, Pyda J, Anteby R, Stratta RJ, Schrope BA, Hardy MA, Buse J, Leventhal JR, Cui W, Hussein S, Niederhaus S, Gaglia J, Desai CS, Wijkstrom M, Kandeel F, Bachul PJ, Becker YT, Wang LJ, Robertson RP, Olaitan OK, Kozlowski T, Abrams PL, Josephson MA, Andreoni KA, Harland RC, Kandaswamy R, Posselt AM, Szot GL, Ricordi C, On Behalf Of The Islets For Us Collaborative. Arguments against the Requirement of a Biological License Application for Human Pancreatic Islets: The Position Statement of the Islets for US Collaborative Presented during the FDA Advisory Committee Meeting. J Clin Med. 2021 Jun 29;10(13):2878. doi: 10.3390/jcm10132878.

PMID: 34209541; PMCID: PMC8269003.

McPherson LJ, Walker ER, Lee YH, Gander JC, Wang Z, Reeves-Daniel AM, Browne T, Ellis MJ, Rossi AP, Pastan SO, Patzer RE; Southeastern Kidney Transplant Coalition. Dialysis Facility Profit Status and Early Steps in Kidney Transplantation in the Southeastern United States. Clin J Am Soc Nephrol.

2021 Jun;16(6):926-936. doi: 10.2215/CJN.17691120.

Epub 2021 May 26. PMID: 34039566; PMCID: PMC8216615.

Abdul Oseini, MD Oseini AM, Hamilton JP, Hammami MB, Kim A, Oshima K, Woreta T, Rizkalla N, Pustavoitau A, Merlo C, Nguyen MC, King EA, Wesson RN, Garonzik-Wang J, Ottmann S, Philosophe B, Cameron AM, Armanios M, Gurakar A. Liver Transplantation in Short TelomereMediated Hepatopulmonary Syndrome Following Bone Marrow Transplantation Using HCV Positive Allografts: A Case Series. Liver Transpl. 2021 Dec;27(12):18441848. doi: 10.1002/lt.26109. Epub 2021 Aug 19.

PMID: 34043865; PMCID: PMC8626542.

Luo Y, Wadhawan S, Greenfield A, Decato BE, Oseini AM, Collen R, Shevell DE, Thompson J, Jarai G, Charles ED, Sanyal AJ. SOMAscan Proteomics Identifies Serum Biomarkers Associated With Liver Fibrosis in Patients With NASH. Hepatol Commun. 2021 Jan 20;5(5):760-773. doi: 10.1002/hep4.1670. PMID: 34027267; PMCID: PMC8122380.

Banini BA, Kumar DP, Cazanave S, Seneshaw M, Mirshahi F, Santhekadur PK, Wang L, Guan HP, Oseini AM, Alonso C, Bedossa P, Koduru SV, Min HK, Sanyal AJ. Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin-Like Phospholipase Domain Containing 3-Mediated Acceleration of Steatohepatitis. Hepatology. 2021 Apr;73(4):12901306. doi: 10.1002/hep.31609. Epub 2021 Mar 19.

PMID: 33131062; PMCID: PMC8046714.

Education

Jason S. Lees, M.D. Vice-Chair of Academic Affairs General Surgery Residency Program Director

New Student Leadership Amanda Celii, MD MS IV Director

Jeremy Johnson, MD MS III Clerkship Co-Director

Alexander Raines, MD MS III Co-Director

Resident Leadership Kristina Booth, MD

Associate Program Director

Alisa Cross, MD

Associate Program Director

Coordinators Laura Blackburn, Ed.D.

Senior Residency Program Coordinator

Sean Rose, M.Ed

Resident Program Coordinator

Brookelynne Davidson

Surgery Clerkship Coordinator & MS IV Electives

Top Row (L>R): Rachael Palumbo, Jaclyn Isabella, Aditi Jalla Bottom Row (L>R): Maureen Mannas, Arthur Grimes, Bailey Kleis

As we bid farewell to our graduating residents, we also welcome our new chiefs.

Arthur Grimes, MD will be pursuing a Trauma Critical Care Fellowship at Wake Forest University in Winston-Salem.

Jaclyn Isabella, MD will be pursuing a Colorectal Surgery Fellowship at Louisiana State University - New Orleans.

Aditi Jalla, MD will be pursuing a Trauma Critical Care Fellowship at the University of Florida Jacksonville.

Bailey Kleis, MD will be pursuing a General Surgery practice with the Air Force.

Maureen Mannas, MD will be pursuing a General Surgery practice.

Rachael Palumbo, MD will be pursuing a Trauma Critical Care Fellowship at Yale in New Haven, Connecticut.

Over the past year, the Department of Surgery has been preparing to be a part of the national initiative that is EQIP. EQIP is a continuous quality improvement program that will allow surgical Program Directors to assess their programs and make necessary changes to improve surgical training with the ultimate goal of producing the highest quality surgeons. With the constant help of Melissa Pachucki, the Department of Surgery was able to complete the contract with EQIP to use their program for the upcoming years. Last year we participated in the beta test thanks to the help of Dr. Laura Blackburn, collecting data points of graduating residents over six years. This information described the residents’ experience as medical students, the surgical training program, and the performance of the individual residents. The use of this data will be able to create predictors that will be used to analyze the next three years of data and create an observation to the predicted ratio for each program to create information that will be organized graphicly as a caterpillar plot. Every program that takes part in EQIP will receive this plot with their results displayed against all other de-identified participating programs to facilitate the creation of learning collaboratives, pool data, add additional data elements, and look at collaborative group’s outcomes against the rest of the EQIP participating centers.

CONGRATULATIONS LAURA BLACKBURN ON EARNING YOUR DOCTOR OF EDUCATION! Laura Blackburn, Ed.D. Senior Residency Program Coordinator

Awards & Recognition Andrea Geddes, MD Alpha Omega Alpha Honor Medical Society induction new member Western Surgical Association Top Paper Presentation for 2020 Arthur Grimes, MD Alpha Omega Alpha Honor Medical Society induction new member Tyler Leiva, MD Certificate of Recognition - Academy of Teaching Scholars 2021 Health Professions Education Research Poster Session

Samara Lewis, MD Certificate of Recognition - Academy of Teaching Scholars 2021 Health Professions Education Research Poster Session Maureen Mannas, MD 2021 Aesculapian Award Nomination - Class of 2022 Aesculapian Award for Excellence in Teaching Intern/Resident Outstanding Resident - General Surgery Whitney Martin, MD Alpha Omega Alpha Honor Medical Society induction new member Elizabeth Joy Trimble, MD Certificate of Recognition - Academy of Teaching Scholars 2021 Health Professions Education Research Poster Session

Presentations Maureen Mannas, MD Southwestern Surgical Congress. Oral Presentation.

"Intravenous Ketorolac in a Level 1 Trauma Population: Is it Safe to Use?". Maui, Hawaii. September 2021.

Taylor Martin, MD Southwestern Surgical Congress. Oral Presentation.

"Clinical Diagnosis of Cholecystitis in Emergency Department Patients with Cholelithiasis is Indication for Cholecystectomy: A Comparison of Clinical, Ultrasounds, and Pathologic Diagnosis.". Maui, Hawaii.

September 2021 Samara Lewis, MD Annual Meeting of the Pediatric Trauma Society. Oral Presentation. "Rural vs. Urban Mechanism of Injury in Pediatric Trauma Fatalities.". Baltimore, MD. November 2021.

Mary 'Abby' Rinchuso, MD Annual Meeting of the Texas Society for Vascular and Endovascular Surgery. Poster Presentation.

"Spontaneous Ulnar Artery Pseudoaneurysm: A Case Report.". Texas. November 2021

Publications Arthur Grimes, MD Lewis SL, Grimes AD, Stewart KE, Landman A, Sarwar Z, Johnson JJ, Kennedy R. Retrospective review of intervention for traumatic blunt spleen injuries in adolescents by trauma center type. Am J Surg. 2021 Dec 15:S0002-9610(21)00736-4. doi: 10.1016/j.amjsurg.2021.12.010. Epub ahead of print.

PMID: 34953577.

Harrell KN, Grimes AD, Albrecht RM, Reynolds JK, Ueland WR, Sciarretta JD, Todd SR, Trust MD, Ngoue M, Thomas BW, Ayuso SA, LaRiccia A, Spalding MC, Collins MJ, Collier BR, Karam BS, de Moya MA, Lieser MJ, Chipko JM Jr, Haan JM, Lightwine KL, Cullinane DC, Falank CR, Phillips RC, Kemp MT, Alam HB, Udekwu PO, Sanin GD, Hildreth AN, Biffl WL, Schaffer KB, Marshall G, Muttalib O, Nahmias J, Shahi N, Moulton SL, Maxwell RA. Management of blunt traumatic abdominal wall hernias: A Western Trauma Association multicenter study. J Trauma Acute Care Surg. 2021 Nov 1;91(5):834-840. doi: 10.1097/TA.0000000000003250. PMID: 34695060.

Publications Arthur Grimes, MD cont'd McGaha P, Klingensmith ME, Cross A, Stewart K, Grimes A, Horton M, Kowdley G, Patel K, Galante J, Wise PE, Delman KA, Joshi ART. Trainee Utilization of the SCORE Curriculum is Associated With Improved ABSITE Performance: A Multi-institutional Study. J Surg Educ. 2021 Nov-Dec;78(6):e196-e200. doi: 10.1016/j.jsurg.2021.06.022. Epub 2021 Aug 9.

PMID: 34384730.

Grimes AD, Kennedy R, Quang C, Albrecht R, Blair S. The Management of Acute Respiratory Distress Syndrome After Near Drowning and Low-Voltage Electrocution. Am Surg. 2021 Jan 2:3134820983189. doi: 10.1177/0003134820983189. Epub ahead of print. PMID: 33393355.

Bailey Kleis, MD Greenwade MM, Moore KN, Gillen JM, Ding K, Rowland MR, Crim AK, Kleis B, Gunderson CC. Factors influencing clinical trial enrollment among ovarian cancer patients. Gynecol Oncol. 2017 Sep;146(3):465-469. doi: 10.1016/j.ygyno.2017.06.035. Epub 2017 Jul 6.

PMID: 28689668.

Aditi Jalla, MD Jalla A., Sturges J., Lees J. Integration of Educational Technology. In: Martin R., Schenarts P. Education and the General Surgeon. PA: Elsevier; 08/01/2021: 693-702.

Lindsay Lindsey, MD Lindsey LJ, Rasmussen LS, Hendrickson LS, Frech ES, Bozell SP, Stewart KE, Kennedy RO, Cross A, Albrecht RM, Celii AM. Trauma Transfers Discharged from the Emergency Department - Is There a Role for Telemedicine? J Trauma Acute Care Surg. 2021 Dec 20. doi: 10.1097/TA.0000000000003505. Epub ahead of print. PMID: 34936588.

Research

Katherine Morris, MD Associate Professor Vice-Chair of Academic and Research Advancement

Research Faculty William Berry, Ph.D. Catherine Hunter, MD Min Li, Ph.D. Lacey McNally, Ph.D. Katherine Morris, MD

Outcomes Research Tabitha Garwe, MPH, Ph.D. Zoona Sarwar, MBBS, MS Kenneth Stewart, MPH, Ph.D.

Research Team

David Alexander, LPN Study Coordinator

Asaleigh Cline

Medical Student Research Coordinator

Theresa Lander

Lead Regulatory Coordinator

Megan Lerner, HT (ASCP) Histology technician

Stephanie Mitchell, RN Lead Study Coordinator

The Department of Surgery at the OU College of Medicine aims to lead the region in clinical trials, high-impact science, and extramural grant funding because we know our patients need us to continue striving toward new discoveries.

Advancing patient care by contributing to high-quality research is a top priority for the Department of Surgery at the University of Oklahoma College of Medicine. To support surgeon-scientists in this effort, OU CARES was founded in 2018, bringing together people with a wide breadth of skills and a strong desire to help both current and future patients.

OU CARES supports our faculty and trainees in projects along the spectrum of translational science, from the bench to comparative effectiveness research. Our research support team includes funded bench scientists, epidemiologists, and biostatisticians with expertise in risk score development and big data sets, regulatory experts, clinical research nurses, and an experienced histologist skilled at creating publicationready images. These services are available to all faculty and trainees at no cost.

To Request Services Check-in with us at the link below and we will be in contact within a week. https://redcap.ouhsc.edu/redcap/surveys/?s=8DCMJAC488

Industry/Investigator-Initiated Trial and Regulatory Compliance Support Our team is currently supporting 136 active IRBs, 15 investigator-initiated trials, as well as 10 industry-sponsored trials.

We assure regulatory compliance, support clinical trials, and negotiate industry trial budgets. If approached about a new industry trial, please send all information in regards to the trial to the email below. We review all trials every Friday and will reach out to the interested PI to discuss feasibility. Please send as much information as possible to ensure a quick turnaround: OUCares@ouhsc.edu. Let us help you from the beginning to get the best results!

Access to REDCAP To gain access to REDCAP and design a HIPAA-compliant database for your project, please click on the link below and log in with your OUHSC credentials. If you have any trouble, please email Asaleigh Cline (asaleigh-cline@ouhsc.edu). https://redcap.ouhsc.edu/.

If you would like help creating the database, click on the box labeled REDCAP design on the intake form. https://redcap.ouhsc.edu/redcap/surveys/?s=8DCMJAC488

Public Outreach and Research Education Our Research Webpage allows us to highlight our services, team members, and your research accomplishments. At https://medicine.ouhsc.edu/Academic-Departments/Surgery/Research you will find the link to request help through REDCAP, the recent Surgery Department Pilot Grant Awardees, and subpages for bench research labs in our Department.

We are working on extending the impact of our department’s research through social media outreach, so please send us your presentations and publications (bonus if you have a picture!) and a link to the publication. We can Tweet it out and increase your readership.

Asaleigh Cline serves as our point of contact for medical students interested in collaborating with faculty and residents within our department. She can help assure the student has all the needed research training and assist with getting them Meditech, PACs, and EMR access for research projects. She matches students who do not yet have a research mentor by assessing their interests and available projects in the REDCAPdatabase. Currently, 63 medical students have been matched with research projects in the last two years! You can reach out to her at Asaleigh-Cline@ouhsc.edu.

Epidemiology, Statistics, Study Design, and Translational Project Development Dr. Garwe leads our Epidemiology and Statistics core facility and can match faculty and residents with the team member best suited for the project after receiving requests through the intake survey (https://redcap.ouhsc.edu/redcap/surveys/?s=8DCMJAC488). Her team can assist with study design, analysis of large national datasets such as NSQIP public user files, and power calculations. Request help early in your study design for best outcomes.

Dr. Berry is a funded scientist with wide expertise in advanced molecular biology techniques and mouse models of disease. Collaborative discussions regarding translational project ideas can also be requested at the above link.

Awards & Recognition William Berry, Ph.D. Patent Award: Animal Wound Model and Methods of Use Discovery: Invention Disclosure No. 2022-031 "Generation of Human DCLK1 ISOFORM 2 (DCLK1-AL) OVEREXPRESSION HUMAN PANCREATIC CANCER CELL LINES" Tabitha Garwe, MPH, Ph.D. 10 Years of Service Recognition Min Li, Ph.D. President's Award Recipient of George Lynn Cross Research Professorship Lacey McNally, Ph.D. Pigs for Pancreatic Surgery - first of 7 Kenneth Stewart, Ph.D. 10 Years of Service Recognition

Grants Department of Surgery Grant Support Current Direct Grant Support $2,271,189.00 William Berry, Ph.D. NIH NIGMS Title: MECHANISMS DRIVING THE FORMATION OF POST-OPERATIVE PERITONEAL ADHESIONS $1,250,000 Morgan Bonds, MD Collaborating with Dr. Whitney Martin Title: Disparities in Cholecystectomies Performed in Oklahoma. - $7,676 Heather Liebe, MD Collaborating with Drs. Catherine Hunter Title: Defining the role of ROCK and cav-1 on autophagy in NEC. - $14,564 Lacey McNally, Ph.D. Student recipient - William MacCuaig: F31 NIH grant Multi-Principle Investigator "Co-evolution of pancreatic cancer and diabetes in a swine model," Sponsored by Student Computer Center team science, The University of Oklahoma.

May 1, 2021 - April 30, 2022 Yuki Nakamura, MD Collaborating with Drs. Aswathy Vaikom House and Elizabeth Trimble Title: Disparities in Cholecystectomies Performed in Oklahoma - $7,760

Patents Lacey McNally, Ph.D. Provisional Patent: Invention Disclosure No. 2022017, "Design and synthesis of cyanine-based small molecules containing quaternary moiety and their methods of use" McNally and Henary

Presentations Tabitha Garwe, MPH, Ph.D. Awarded Oklahoma Center for the Advancement of Science Technology Grant (OCAST) - Geriatric Trauma Secondary Triage: Development and Validation of a Risk Score to Identify Patients Requiring Transfer to a Level I/II Trauma Facility Lacey McNally, Ph.D. American Pancreatic Association Annual Meeting.

"Active targeting has superior influence to nanoparticle size in facilitating tumor specific uptake in orthotopic pancreatic cancer in vivo." Oral Presentation.

November 5, 2021. FL. American Pancreatic Association Annual Meeting.

"S100A9 targeted nanoparticles deliver rapamycin to treat pancreatic adenocarcinoma." Oral Presentation. November 5, 2021. FL. American Pancreatic Association. "Treatment of chemoresistant pancreatic cancer with nanodelivered echinomycin to target autophagy." Oral Presentation.

November 5, 2021. FL.

Publications Saunders AS, Bender DE, Ray AL, Wu X, Morris KT. Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. PLoS ONE, 2021 Feb; 16(2): e0247233. doi: 10.1371/journal.pone.0247233.

Rozich NS, Lewis S, Chen S, Stewart KE, Stout MB, Dooley WC, Fischer LF, Morris KT. Women survive longer than men undergoing cytoreductive surgery and HIPEC for appendiceal cancer. PLoS ONE, 2021 Apr;16(4): e0250726. doi: 10.1371/journal.pone.0250726.

Grimes AD, Stewart KT, Morris KT, Dunn GD, Booth KK, Carter SN, Garwe T, Sarwar Z, and Fischer LE. American Surgeon, 2021 Oct 11:31348211047474. doi: 10.1177/00031348211047474.

Publications Panneerselvam J, Madka V, Rai R, Morris KT, Houchen CW, Chandrakesan P, and Rao CV. Inflammatory mediators and gut microbial toxins drive colon tumorigenesis by IL-23 dependent mechanism. Cancers (Basel). 2021 Oct 14; 13(20): 5159. doi: 10.3390/cancers13205159.

Xu Y-F, Xu X, Bhandari K, Gin A, Rao CV, Morris KT, Hannafon BN, and Ding W-Q. Isolation of extra-cellular vesicles in the context of pancreatic adenocarcinomas: Addition of one stringent filtration step improves recovery of specific microRNAs. PLoS ONE, 2021 Nov; 16(11): e0259563. doi: 10.1371/journal.pone.0259563.

Jones MA, MacCuaig WM, Frickenstein AN, Camalan S, Gurcan M, Holter-Chakrabarty, J, Morris KT, and McNally LM. “Molecular Imaging of Inflammatory Disease.” Biomedicines, 2021 Feb; 9 (152). doi: 10.3390/biomedicines/9020152.

Harrell KN, Grimes AD, Albrecht RM, Reynolds JK, Ueland WR, Sciarretta JD, Todd SR, Trust MD, Ngoue M, Thomas BW, Ayuso SA, LaRiccia A, Spalding MC, Collins MJ, Collier BR, Karam BS, de Moya MA, Lieser MJ, Chipko JM Jr, Haan JM, Lightwine KL, Cullinane DC, Falank CR, Phillips RC, Kemp MT, Alam HB, Udekwu PO, Sanin GD, Hildreth AN, Biffl WL, Schaffer KB, Marshall G, Muttalib O, Nahmias J, Shahi N, Moulton SL, Maxwell RA. Management of blunt traumatic abdominal wall hernias: A Western Trauma Association multicenter study.

J Trauma Acute Care Surg. 2021 Nov 1;91(5):834-840. doi: 10.1097/TA.0000000000003250. PMID: 34695060.

Bonds M, Garwe T, Rozich N, Oluborode B, Sarwar Z, Postier RG, Morris KT. Risk Factors Associated With Readmission After Pancreatectomy: A Single-Institution Retrospective Cohort Study. Am Surg. 2021 Jan 31:3134820988824. doi: 10.1177/0003134820988824.

Epub ahead of print. PMID: 33517699 MacCuaig WM, Thomas, Carlos-Sorto JC, GomezGutierrez JG, Alexander AC, Wellberg EA, Grizzle WE, McNally LR. Differential expression of microRNA between triple negative breast cancer patients of African American and European American descent. Biotech and Histochem. 2021 MacCuaig WM, Fouts B.L, McNally MW, Grizzle WE, Chuong P, Samykutty A, Mukherjee P, Li M, Jasinski JB, Behkam B, McNally LR. Active Targeting Significantly Outperforms Nanoparticle Size in Facilitating TumorSpecific Uptake in Orthotopic Pancreatic Cancer. ACS Applied Materials & Interfaces. 2021 Oct 15; 13(42): 49614-30

Publications MacCuaig WM, Fouts B.L, McNally MW, Grizzle WE, Chuong P, Samykutty A, Mukherjee P, Li M, Jasinski JB, Behkam B, McNally LR. Active Targeting Significantly Outperforms Nanoparticle Size in Facilitating TumorSpecific Uptake in Orthotopic Pancreatic Cancer. ACS Applied Materials & Interfaces. 2021 Oct 15; 13(42): 49614-30 Frickenstein, A. N., Hagood, J., Britten, C. N., Abbott, B. S., McNally, M. W., Vopat, C. A., Patterson, E. G., Jain, A., Walters, K. B., McNally, L. R.# (2021). Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect. Pharmaceutics, 13(4), 570.

PMID: 33920503. DOI: 10.3390/pharmaceutics13040570 Zhou, Z., Zhang, J., Xu, C., Yang, J., Liu, M., Shi, X., Li, X., Zhan, H., Chen, W., McNally, L. R., Fung, K. M., Luo, W., Houchen, C., He, Y., Zhang, C., Li, M. (2021). An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer. EBioMedicine, 65, 103271. PMID: 33714027. DOI: 10.1016/j.ebiom.2021.103271 Miller, B., Chalfant, H., Thomas, A., Wellberg, E., Henson, C., McNally, M. W., Grizzle, W. R., Jain, A., McNally, L. R.# (2021). Diabetes, Obesity and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer. International Journal of Molecular Sciences, 22(5), 2757. PMID: 33803201. DOI: 10.3390/ijms22052757 Laramie, M. D., Fouts, B. L., MacCuaig, W. M., Jones, M. A., Mukherjee, P., Behkam, B., McNally, L. R.#, Henary, M. M. (2021). Synthesis of Cy5 Dye Derivatives for Optoacoustic Imaging of Pancreatic Cancer. Scientific Reports, 11, 4366. DOI: https://doi.org/10.1038/s41598-021-83658-3

Administration "Great things in business are never done by one person; they're done by a team of people." - Steve Jobs The Department of Surgery staff supports the day-to-day (and often evening, weekend & holiday) needs of the department. They all play a key role in the success of the department.

Chair's Office Jessica Capetillo Brian Roberts

Administrative Office Tai Athay Becky Bowlus Paige Brannon Jennifer Burks

Business Office Warren Churchill Heather Dees Mary Sheets Lisa Suriano Cheri Warren Nicole Warren

Susan Cloer

Education Office Laura Blackburn Brookelynne Davidson Magali Ochoa Sean Rose

Kristen Earnhardt Leisel Gowens Shelly Jones Jayde Leon Saeko Lord Shawna McDaniel Monika Medwayosh Shannon Myers Nashona Ragland Crystal Taylor

Research Office David Alexander Xue Cai Asaleigh Cline James Griffith Theresa Lander Megan Lerner Stephanie Mitchell Zoona Sarwar Camille Schlegel Kenneth Stewart

Get Connected https://www.oumedicine.com/department-of-surgery https://www.facebook.com/OUsurgery/ @OU_Surgery or @OUPedSurg #OUsurgery or #OUtrauma ou_surgery or ou_prs

Caught on Social Media

Caught on Social Media

Chief Surgical Residents & Fellows Graduation

Surgery Research Symposium

Halloween 2021

Top Row: Heather Dees, Shawna McDaniel, Sean Rose, Jessica Capetillo, Lisa Suriano, Shannon Myers Bottom Row: Nicole Warren, Jayde Leon, Crystal Taylor, Magali Ochoa, Saeko Lord, Laura Blackburn, Monika Medwayosh, Tammy Austin

Christmas 2021

Top Row: Cheri Warren, Sean Rose, Shannon Myers, Shawna McDaniel, Laura Blackburn, Brian Roberts Bottom Row: Becky Bowlus, Jessica Capetillo, Nicole Warren, Jayde Leon

Giving

Surgeons at the University of Oklahoma Health Sciences Center are dedicated to excellence in education, research and patient care. We appreciate the generous support of patients and their families, alumni, physicians, friends and businesses.

Your gift can help improve a child’s health, award a resident a scholarship, or provide funds for research, equipment, computers, library materials and more. Every gift we receive makes a difference, and we sincerely thank you for your generosity.

Development Office University of Oklahoma Health Sciences Center P.O. Box 26901 Oklahoma City, OK 73126 405-271-2300

If you would like to contribute an article, news item or event notice for our newsletter, please email: jessica-capetillo@ouhsc.edu Next Issue August 2022